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https://www.readbyqxmd.com/read/28424560/an-exploratory-study-of-host-polymorphisms-in-genes-that-clinically-characterize-breast-cancer-tumors-and-pretreatment-cognitive-performance-in-breast-cancer-survivors
#1
Theresa A Koleck, Catherine M Bender, Beth Z Clark, Christopher M Ryan, Puja Ghotkar, Adam Brufsky, Priscilla F McAuliffe, Priya Rastogi, Susan M Sereika, Yvette P Conley
PURPOSE: Inspired by the hypothesis that heterogeneity in the biology of breast cancers at the cellular level may account for cognitive dysfunction symptom variability in survivors, the current study explored relationships between host single-nucleotide polymorphisms (SNPs) in 25 breast cancer-related candidate genes (AURKA, BAG1, BCL2, BIRC5, CCNB1, CD68, CENPA, CMC2, CTSL2, DIAPH3, ERBB2, ESR1, GRB7, GSTM1, MELK, MKI67, MMP11, MYBL2, NDC80, ORC6, PGR, RACGAP1, RFC4, RRM2, and SCUBE2), identified from clinically relevant prognostic multigene-expression profiles for breast cancer, and pretreatment cognitive performance...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28325316/removal-of-dye-by-carboxymethyl-cellulose-acrylamide-and-graphene-oxide-via-a-free-radical-polymerization-process
#2
Kokkarachedu Varaprasad, Tippabattini Jayaramudu, Emmanuel Rotimi Sadiku
Carboxymethyl cellulose has been used for the design of novel engineered hydrogels in order to obtain effective three-dimensional structures for industrial applications. In this work, dye removal carboxymethyl cellulose-acrylamide-graphene oxide (CMC-AM-GO) hydrogels were prepared by a free-radical polymerization method. The GO was developed by the modified Hummers method. The CMC-AM-GO and GO were characterized by FTIR, XRD and SEM. The swelling and swelling kinetics were calculated using gravimetric process...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28045184/synthesis-and-characterization-of-layered-metal-sulfates-containing-m-%C3%AE-3-oh-f-2-m-mg-co-diamond-chains
#3
Subba R Marri, Sudipta Mahana, Dinesh Topwal, J N Behera
Cobalt and magnesium sulfates of the compositions, [C4N2H12]2[Co3F2(SO4)3(H2O)2], (1) and [NH4]2[Mg3(OH)2(SO4)3(H2O)2], (2), respectively, have been synthesized under hydro/solvothermal conditions, and are characterized by IR spectra, elemental analysis, powder X-ray diffraction (PXRD), energy-dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), and X-ray single-crystal diffraction. 1 and 2 crystallized in the orthorhombic space groups Pnma and Cmc2 respectively. While 1 is templated by the organic piperazinium cation, 2 is obtained in the presence of ammonium ions...
January 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27396495/dielectric-analysis-for-the-spherical-and-rodlike-micelle-aggregates-formed-from-a-gemini-surfactant-driving-forces-of-micellization-and-stability-of-micelles
#4
Shanshan Wang, Kongshuang Zhao
The self-aggregation behavior of Gemini surfactant 12-2-12 (ethanediyl-1,2-bis(dimethyldodecylammonium bromide)) in water was investigated by dielectric relaxation spectroscopy (DRS) over a frequency range from 40 Hz to 110 MHz. Dielectric determination shows that well-defined spherical micelles formed when the concentration of the surfactant was above a critical micelle concentration CMC1 of 3 mM and rodlike micelles formed above CMC2, 16 mM. The formation mechanism of the spherical micelles and their transition mechanism to clubbed micelles were proposed by calculating the degree of counterion binding of the micelles...
August 2, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27190999/a-novel-chemically-modified-curcumin-normalizes-wound-healing-in-rats-with-experimentally-induced-type-i-diabetes-initial-studies
#5
Yazhou Zhang, Steve A McClain, Hsi-Ming Lee, Muna S Elburki, Huiwen Yu, Ying Gu, Yu Zhang, Mark Wolff, Francis Johnson, Lorne M Golub
Introduction. Impaired wound-healing in diabetics can lead to life-threatening complications, such as limb amputation, associated in part with excessive matrix metalloproteinase- (MMP-) mediated degradation of collagen and other matrix constituents. In the current study, a novel triketonic chemically modified curcumin, CMC2.24, was tested for efficacy in healing of standardized skin wounds in streptozotocin-induced diabetic rats. Initially, CMC2.24 was daily applied topically at 1% or 3% concentrations or administered systemically (oral intubation; 30 mg/kg); controls received vehicle treatment only...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27022301/identification-and-prioritization-of-candidate-genes-for-symptom-variability-in-breast-cancer-survivors-based-on-disease-characteristics-at-the-cellular-level
#6
Theresa A Koleck, Yvette P Conley
Research is beginning to suggest that the presence and/or severity of symptoms reported by breast cancer survivors may be associated with disease-related factors of cancer. In this article, we present a novel approach to the identification and prioritization of biologically plausible candidate genes to investigate relationships between genomic variation and symptom variability in breast cancer survivors. Cognitive dysfunction is utilized as a representative breast cancer survivor symptom to elucidate the conceptualization of and justification for our cellular, disease-based approach to address symptom variability in cancer survivors...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/26863117/differential-susceptibility-of-human-sp-b-genetic-variants-on-lung-injury-caused-by-bacterial-pneumonia-and-the-effect-of-a-chemically-modified-curcumin
#7
Yongan Xu, Lin Ge, Osama Abdel-Razek, Sumeet Jain, Zhiyong Liu, Yucai Hong, Gary Nieman, Francis Johnson, Lorne M Golub, Robert N Cooney, Guirong Wang
Staphylococcus aureus is a common cause of nosocomial pneumonia frequently resulting in acute respiratory distress syndrome (ARDS). Surfactant protein B (SP-B) gene expresses two proteins involved in lowering surface tension and host defense. Genotyping studies demonstrate a significant association between human SP-B genetic variants and ARDS. Curcumins have been shown to attenuate host inflammation in many sepsis models. Our hypothesis is that functional differences of SP-B variants and treatment with curcumin (CMC2...
April 2016: Shock
https://www.readbyqxmd.com/read/26769491/disruption-of-pho13-improves-ethanol-production-via-the-xylose-isomerase-pathway
#8
Takahiro Bamba, Tomohisa Hasunuma, Akihiko Kondo
Xylose is the second most abundant sugar in lignocellulosic materials and can be converted to ethanol by recombinant Saccharomyces cerevisiae yeast strains expressing heterologous genes involved in xylose assimilation pathways. Recent research demonstrated that disruption of the alkaline phosphatase gene, PHO13, enhances ethanol production from xylose by a strain expressing the xylose reductase (XR) and xylitol dehydrogenase (XDH) genes; however, the yield of ethanol is poor. In this study, PHO13 was disrupted in a recombinant strain harboring multiple copies of the xylose isomerase (XI) gene derived from Orpinomyces sp...
March 2016: AMB Express
https://www.readbyqxmd.com/read/25878183/sleep-disordered-breathing-advances-cognitive-decline-in-the-elderly
#9
Ricardo S Osorio, Tyler Gumb, Elizabeth Pirraglia, Andrew W Varga, Shou-En Lu, Jason Lim, Margaret E Wohlleber, Emma L Ducca, Viachaslau Koushyk, Lidia Glodzik, Lisa Mosconi, Indu Ayappa, David M Rapoport, Mony J de Leon
OBJECTIVE: To examine whether the presence of sleep-disordered breathing (SDB) is associated with an earlier age at mild cognitive impairment (MCI) or Alzheimer disease (AD)-dementia onset in participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We also examined whether continuous positive airway pressure (CPAP) use is associated with delayed onset of cognitive decline. METHODS: From the ADNI cohort, 3 subsets with progressively stringent criteria were created in a step-wise manner...
May 12, 2015: Neurology
https://www.readbyqxmd.com/read/25134593/multi-scale-times-and-modes-of-fast-and-slow-relaxation-in-solutions-with-coexisting-spherical-and-cylindrical-micelles-according-to-the-difference-becker-d%C3%A3-ring-kinetic-equations
#10
Ilya A Babintsev, Loran Ts Adzhemyan, Alexander K Shchekin
The eigenvalues and eigenvectors of the matrix of coefficients of the linearized kinetic equations applied to aggregation in surfactant solution determine the full spectrum of characteristic times and specific modes of micellar relaxation. The dependence of these relaxation times and modes on the total surfactant concentration has been analyzed for concentrations in the vicinity and well above the second critical micelle concentration (cmc2) for systems with coexisting spherical and cylindrical micelles. The analysis has been done on the basis of a discrete form of the Becker-Döring kinetic equations employing the Smoluchowsky diffusion model for the attachment rates of surfactant monomers to surfactant aggregates with matching the rates for spherical aggregates and the rates for large cylindrical micelles...
August 14, 2014: Journal of Chemical Physics
https://www.readbyqxmd.com/read/24086245/prostate-cancer-stem-cell-targeted-efficacy-of-a-new-generation-taxoid-sbt-1214-and-novel-polyenolic-zinc-binding-curcuminoid-cmc2-24
#11
Galina I Botchkina, Edison S Zuniga, Rebecca H Rowehl, Rosa Park, Rahuldev Bhalla, Agnieszka B Bialkowska, Francis Johnson, Lorne M Golub, Yu Zhang, Iwao Ojima, Kenneth R Shroyer
BACKGROUND: Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells (CSCs) is responsible for cancer development and exceptional drug resistance, representing a highly important therapeutic target. The present study evaluated CSC-specific alterations induced by new-generation taxoid SBT-1214 and a novel polyenolic zinc-binding curcuminoid, CMC2.24, in prostate CSCs. PRINCIPAL FINDINGS: The CD133(high)/CD44(high) phenotype was isolated from spontaneously immortalized patient-derived PPT2 cells and highly metastatic PC3MM2 cells...
2013: PloS One
https://www.readbyqxmd.com/read/23379686/self-aggregation-properties-of-ionic-liquid-1-3-didecyl-2-methylimidazolium-chloride-in-aqueous-solution-from-spheres-to-cylinders-to-bilayers
#12
María Figueira-González, Vitor Francisco, Luis García-Río, Eduardo F Marques, Mercedes Parajó, Pedro Rodríguez-Dafonte
The self-aggregation behavior of the double-chained ionic liquid (IL) 1,3-didecyl-2-methylimidazolium chloride ([C10C10mim]Cl) in aqueous solution has been investigated with a number of different experimental techniques. Two cmc values (cmc1 and cmc2) are obtained from conductivity measurements. The fraction of neutralized charge on the micellar surface suggests that cmc1 corresponds to the formation of spherical micelles and cmc2 to the transition from spherical to cylindrical micelles. Data obtained from fluorescence spectroscopy (using pyrene and Nile red as chemical probes), fluorescence anisotropy (using rhodamine B as probe), and chemical shift (1)H NMR (in D2O) provide a picture that is also consistent with a sphere-to-cylinder transition...
March 14, 2013: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/23267073/cell-cycle-dependent-deposition-of-cenp-a-requires-the-dos1-2-cdc20-complex
#13
Marlyn Gonzalez, Haijin He, Siyu Sun, Chen Li, Fei Li
Centromeric histone CENP-A, a variant of canonical histone H3, plays a central role in proper chromosome segregation. Loading of CENP-A at centromeres is cell cycle-regulated: parental CENP-A is deposited at centromeres during S phase, whereas newly synthesized CENP-A is deposited during later stages of the cell cycle. The mechanisms involved in deposition of CENP-A at centromeres during S phase remain poorly understood. In fission yeast, loading of CENP-A during S phase is regulated by the GATA-type factor, Ams2...
January 8, 2013: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/23244465/structural-phase-transitions-on-agcus-stromeyerite-mineral-under-compression
#14
D Santamaria-Perez, A Morales-Garcia, D Martinez-Garcia, B Garcia-Domene, C Mühle, M Jansen
The structural behavior of mineral Stromeyerite, AgCuS, has been studied by means of angle-dispersive X-ray diffraction measurements up to 13 GPa and ab initio total-energy calculations. Two high-pressure phase transitions are found at 1.4 and 5.7 GPa, from the initial distorted Ni(2)In-type phase (AuRbS-type, RP, space group Cmc2(1)) through an anti-PbClF-type phase (HP1, space group P4/nmm) to a monoclinic distortion of this latter phase (HP2, space group P2(1)/m). The collapse of the metal-metal interatomic distances at the RP-HP1 transition suggests a stronger metallic behavior of the high-pressure phase...
January 7, 2013: Inorganic Chemistry
https://www.readbyqxmd.com/read/23046251/syntheses-structures-physical-properties-and-electronic-structures-of-ba2mlnte5-m-ga-and-ln-sm-gd-dy-er-y-m-in-and-ln-ce-nd-sm-gd-dy-er-y
#15
Wenlong Yin, Wendong Wang, Lei Bai, Kai Feng, Youguo Shi, Wenyu Hao, Jiyong Yao, Yicheng Wu
The 12 new rare-earth tellurides Ba(2)MLnTe(5) (M = Ga and Ln = Sm, Gd, Dy, Er, Y; M = In and Ln = Ce, Nd, Sm, Gd, Dy, Er, Y) have been synthesized by solid-state reactions. The two compounds Ba(2)GaLnTe(5) (Ln = Sm, Gd) are isostructural and crystallize in the centrosymmetric space group P1, while the other 10 compounds belong to another structure type in the noncentrosymmetric space group Cmc2(1). In both structure types, there are one-dimensional anionic (1)(∞)[MLnTe(5)](4-) chains built from LnTe(6) octahedra and MTe(4) (M = Ga, In) tetrahedra, but the connectivity between the LnTe(6) octahedra and MTe(4) tetrahedra is different for the two structure types...
November 5, 2012: Inorganic Chemistry
https://www.readbyqxmd.com/read/23030763/synthesis-structural-characterization-and-ab-initio-study-of-cu-5-%C3%AE-in-2-x-sb-2-x-a-new-b8-related-structure-type
#16
Carola J Müller, Sven Lidin, Susana Ramos de Debiaggi, Crispulo E Deluque Toro, Armando Fernández Guillermet
A new ternary orthorhombic compound with the formula Cu(5+δ)In(2+x)Sb(2-x), crystallizing in the space group Cmc2(1) with 36 atoms per unit cell [a = 10.1813(4) Å, b = 8.4562(4) Å, c = 7.3774(2) Å, Z = 4], has been synthesized by conventional high-temperature methods. The structure is based on the B8 archetype (NiAs/Ni(2)In) and features In/Sb ordering as well as ordering of interstitial copper. Details of the experimental study and the structural parameters of this compound are reported in the first part of the work...
October 15, 2012: Inorganic Chemistry
https://www.readbyqxmd.com/read/22978349/elucidating-the-mechanism-of-multiferroicity-in-nh4-3cr-o2-4-and-its-tailoring-by-alkali-metal-substitution
#17
Raghabendra Samantaray, Ronald J Clark, Eun S Choi, Naresh S Dalal
The antiferromagnetic Cr(V) peroxychromates, M(3)Cr(O(2))(4), M = K, Rb, and Cs, become ferroelectric when mixed with NH(4)(+), but the underlying mechanism is not understood. Our dielectric relaxation, Raman scattering, and high-frequency EPR measurements on the M(3-x)(NH(4))(x)Cr(O(2))(4) family clarify this mechanism. At 295 K, (NH(4))(3)Cr(O(2))(4) is tetragonal (I42m), with the NH(4)(+) ions occupying two distinctly different sites, N1 and N2. A ferroelectric transition at T(c1) = 250 K is revealed by λ-type anomalies in C(p) and dielectric constant, and lowering of symmetry to Cmc2(1)...
September 26, 2012: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/22851016/a-novel-transcriptional-regulator-clbr-controls-the-cellobiose-and-cellulose-responsive-induction-of-cellulase-and-xylanase-genes-regulated-by-two-distinct-signaling-pathways-in-aspergillus-aculeatus
#18
Emi Kunitake, Shuji Tani, Jun-ichi Sumitani, Takashi Kawaguchi
The cellobiose- and cellulose-responsive induction of the FIII-avicelase (cbhI), FII-carboxymethyl cellulase (cmc2), and FIa-xylanase (xynIa) genes is not regulated by XlnR in Aspergillus aculeatus, which suggests that this fungus possesses an unknown cellulase gene-activating pathway. To identify the regulatory factors involved in this pathway, we constructed a random insertional mutagenesis library using Agrobacterium tumefaciens-mediated transformation of A. aculeatus NCP2, which harbors a transcriptional fusion between the cbhI promoter (P ( CBHI )) and the orotidine 5'-phosphate decarboxylase gene (pyrG)...
March 2013: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/22830350/design-synthesis-and-biological-activity-of-new-polyenolic-inhibitors-of-matrix-metalloproteinases-a-focus-on-chemically-modified-curcumins
#19
Yu Zhang, Ying Gu, Hsi-Ming Lee, Elena Hambardjieva, Kveta Vranková, Lorne M Golub, Francis Johnson
Matrix metalloproteinases (MMPs) are essential for the degradation and turnover of components of the extracellular matrix (ECM) and, when pathologically elevated, mediate connective tissue loss (including bone destruction) in various inflammatory and other diseases. Tetracyclines (TCs) are known inhibitors of mammalian-derived MMPs, and non-antibiotic formulations of Doxycycline are FDA-approved to treat periodontitis and the chronic inflammatory skin disease, rosacea. Because the C-11/ C-12 diketonic moiety of the tetracyclines is primarily responsible, through zinc-binding, for MMP inhibition, we have uniquely modified curcumin as a "core" molecule, since it contains a similar enolic system and is known to have beneficial effects in diseases where connective-tissue loss occurs...
2012: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/22671989/syntheses-structures-optical-and-magnetic-properties-of-ba2mlnse5-m-ga-in-ln-y-nd-sm-gd-dy-er
#20
Wenlong Yin, Kai Feng, Wendong Wang, Youguo Shi, Wenyu Hao, Jiyong Yao, Yicheng Wu
The twelve quaternary rare-earth selenides Ba(2)MLnSe5 (M = Ga, In; Ln = Y, Nd, Sm, Gd, Dy, Er) have been synthesized for the first time. The compounds Ba(2)GaLnSe(5) (Ln = Y, Nd, Sm, Gd, Dy, Er) are isostructural and crystallize in a new structure type in the centrosymmetric space group P ̅1 of the triclinic system while the isostructural compounds Ba(2)InLnSe(5) (Ln = Y, Nd, Sm, Gd, Dy, Er) belong to the Ba(2)BiInS(5) structure type and crystallize in the noncentrosymmetric space group Cmc2(1) of the orthorhombic system...
June 18, 2012: Inorganic Chemistry
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