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ductus venosus

Sarah Schalekamp-Timmermans, Jerome Cornette, Albert Hofman, Willem A Helbing, Vincent W V Jaddoe, Eric A P Steegers, Bero O Verburg
BACKGROUND: There are sex differences in the risk of development of cardiovascular disease (CVD). According to the developmental origins of health and disease paradigm (DOHaD), CVD originates in fetal life. This study examines fetal sex differences in cardiovascular development in utero. METHODS: In 1028 pregnant women, we assessed fetal circulation using pulsed wave Doppler examinations between 28 and 34 weeks gestation. To test associations between fetal sex and fetal circulation measurements, linear regression models were used adjusting for fetal size, gestational age, and fetal heart rate...
2016: Biology of Sex Differences
Wei-Hsiu Chiu, Shy-Ming Lee, Tao-Hsin Tung, Xiao-Mei Tang, Ren-Shyan Liu, Ran-Chou Chen
Antenatal diagnosis of congenital heart disease (CHD) is still low even though screening was first introduced over 25 years ago. The purpose of our study was to determine the efficacy of a second-trimester prenatal ultrasonographic method of screening for CHD.From September 2012 to September 2013, the length and width of the fetal ductus venosus were measured sonographically in 1006 singleton fetuses, and the ratio of length to width was calculated. The accuracy of each fetal measurement and Doppler ultrasonography were determined...
September 2016: Medicine (Baltimore)
R Choudhary, S B Choudhary, A Khurana
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
A Corbacioglu Esmer, G Turkyilmaz, T Sarac Sivrikoz, I Kalelioglu, R Has, A Yuksel
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
C Hofstaetter, S Gudmundsson
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Oliver C Burdall, Tassos Grammatikopoulos, Maria Sellars, Nedim Hadzic, Mark Davenport
A link between congenital vascular malformation (CVM) of the liver and Trisomy 21 has been suggested. We reviewed all children with Trisomy 21 referred for investigation to a specialist paediatric hepatobiliary unit (1985-2015).Forty-five children with Trisomy 21 were identified; 7 (15%) had a defined CVMs (4 female). All such infants were also diagnosed with a range of cardiac defects. CVMs were divided according to the nature of the vascular connection.Group (i) (n = 3) Abnormal veno-venous anomaly. This included porto-caval shunt and patent ductus venosus (n = 2)...
September 6, 2016: Journal of Pediatric Gastroenterology and Nutrition
Seneesh Vikraman Kumar, Vipin Chandra, Bijoy Balakrishnan, Meenu Batra, Rekha Kuriakose, Gopinathan Kannoly
The objective of our study was to appraise the incidence and significance of persistent right umbilical vein (PRUV), the most common foetal venous aberration. Based on a south Indian antenatal cohort, we identified 23 cases of PRUV amongst 20,452 foetuses of consecutive pregnancies, from 2009 to 2014, yielding an incidence of 1 in 889 total births (0.11%). The median maternal age was 24 (IQR, 22-26) years, and median gestational age at diagnosis was 23 (IQR, 22-24) weeks. Intrahepatic drainage of PRUV was seen in 91...
September 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Grigorios A Karampas, Makarios I Eleftheriades, Konstantinos C Panoulis, Myrto D Rizou, Alexander D Haliassos, Dimitra K Metallinou, George P Mastorakos, Demetrios A Rizos
OBJECTIVE: To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11+0 to 13+6 and 20+1 to 25+6 weeks' gestation. STUDY DESIGN: Prospectively enrolled women at 11+0 to 13+6 and 20+1 to 25+6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein - A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Sofia Mastrodima, Ranjit Akolekar, Guelen Yerlikaya, Thanasis Tzelepis, Kypros H Nicolaides
OBJECTIVES: To develop a model for prediction of stillbirth based on a combination of maternal characteristics and medical history with first trimester biochemical and biophysical markers and evaluate the performance of screening of this model for all stillbirths and those due to impaired placentation and unexplained causes. METHODS: This was a prospective screening study of 76,897 singleton pregnancies including 76,629 live births and 268 (0.35%) antepartum stillbirths; 157 (59%) were secondary to impaired placentation and 111 (41%) were due to other or unexplained causes...
August 26, 2016: Ultrasound in Obstetrics & Gynecology
Ranjit Akolekar, Mirian Machuca, Mariane Mendes, Vasileios Paschos, Kypros H Nicolaides
OBJECTIVES: To investigate whether measurement of maternal serum placental growth factor (PLGF) at 11-13 weeks' gestation improves the performance of screening for stillbirths that is achieved by a combination of maternal factors and first trimester biomarkers such as maternal serum pregnancy associated plasma protein-A (PAPP-A), ductus venosus pulsatility index for veins (DV-PIV) and uterine artery pulsatility index (UT-PI) PI and to evaluate the performance of screening of this model for all stillbirths and those due to impaired placentation and unexplained causes...
August 26, 2016: Ultrasound in Obstetrics & Gynecology
Taraneh Rezaee, Kamran Hassani
Abortion of the fetus due to a disease has been dramatically increased in the last decades. There is a still lack of knowledge on the various types of diseases which lead fetus to a vulnerable circumstance. The transport of oxygenated blood from the placenta to the human fetus has been an important clinical feature in Doppler velocimetry studies, especially the Ductus Venosus (DV). The DV connects intra-abdominal portion of the umbilical vein and the Inferior Vena Cava (IVC) at the inlet of the right atrium and is, therefore, important when examining the fetus state of health...
August 10, 2016: Bioscience Reports
Franz Bahlmann, Ammar Al Naimi, Manfred Ossendorf, Monica Schmidt-Fittschen, Arne Willruth
BACKGROUND: Erythropoietin seems to play an important role in the regulation of fetal hypoxemia. The present prospective study was designed to determine if changes in erythropoietin levels can be found in fetuses with severe early-onset growth restriction and hemodynamic compromise. METHODS AND RESULTS: Erythropoietin, hemoglobin, hematocrit, platelet counts, normoblasts, lacate, arterial and venous blood gasses in the umbilical cord were determined in 42 fetuses with fetal growth restriction (IUGR) with absent (zero-flow) and 26 IUGR fetuses with retrograde end-diastolic flow (reverse-flow) in the umbilical artery...
August 9, 2016: Journal of Perinatal Medicine
Marcin Wiechec, Anna Knafel, Agnieszka Nocun, Ewa Wiercinska, Artur Ludwin, Inga Ludwin
OBJECTIVES: To identify the most common first-trimester ultrasound findings in Turner syndrome (TS). To evaluate which first-trimester findings can be best used to predict the likelihood of TS. METHODS: This was a prospective study, based on singleton pregnancies. The referrals included 6210 patients. Scan protocol covered a review of the early fetal anatomy and markers of aneuploidy. RESULTS: Study population comprised 5644 pregnancies: 5613 with a normal karyotype and 31 cases of TS...
August 29, 2016: Journal of Maternal-fetal & Neonatal Medicine
Hans Wolf, Birgit Arabin, Christoph C Lees, Dick Oepkes, Federico Prefumo, Baskaran Thilaganathan, Tullia Todros, Gerard H A Visser, Caterina M Bilardo, Jan B Derks, Anke Diemert, Johannes J Duvekot, Enrico Ferrazzi, Tiziana Frusca, Kurt Hecher, Neil Marlow, Pasquale Martinelli, Eva Ostermayer, Aris T Papageorghiou, Hubertina C J Scheepers, Dietmar Schlembach, K T M Schneider, Adriana Valcamonico, Aleid van Wassenaer-Leemhuis, Wessel Ganzevoort
OBJECTIVES: To explore if in early fetal growth restriction (FGR) the longitudinal pattern of short-term fetal heart rate (FHR) variation (STV) can be used for identifying imminent fetal distress and if abnormalities of FHR registration associate with two-year infant outcome. METHODS: The original TRUFFLE study assessed if in early FGR the use of ductus venosus Doppler pulsatility index (DVPI), in combination with a safety-net of very low STV and / or recurrent decelerations, could improve two-year infant survival without neurological impairment in comparison to computerised cardiotocography (cCTG) with STV calculation only...
August 3, 2016: Ultrasound in Obstetrics & Gynecology
Lara Lehtoranta, Olli Vuolteenaho, Jukka Laine, Lauri Polari, Eeva Ekholm, Juha Räsänen
INTRODUCTION: Human type 1 diabetic pregnancy is associated with placental structural and hemodynamic abnormalities. We hypothesized that in rat fetuses of hyperglycemic dams, placental and fetal blood flow velocity waveforms demonstrate compromised hemodynamics when compared to control fetuses, and these hemodynamic parameters correlate with placental structural abnormalities at near term gestation. METHODS: Streptozotocin-induced maternal hyperglycemia group comprised 10 dams with 107 fetuses and the control group 20 dams with 219 fetuses...
August 2016: Placenta
Nicole B Burger, Monique C Haak, Evelien Kok, Christianne J M de Groot, Weinian Shou, Peter J Scambler, Youngsook Lee, Eunjin Cho, Vincent M Christoffels, Mireille N Bekker
BACKGROUND: In human fetuses with cardiac defects and increased nuchal translucency, abnormal ductus venosus flow velocity waveforms are observed. It is unknown whether abnormal ductus venosus flow velocity waveforms in fetuses with increased nuchal translucency are a reflection of altered cardiac function or are caused by local morphological alterations in the ductus venosus. AIM: The aim of this study was to investigate if the observed increased nuchal translucency, cardiac defects and abnormal lymphatic development in the examined mouse models are associated with local changes in ductus venosus morphology...
October 2016: Early Human Development
S J Eschbach, L S T M Boons, E van Zwet, J M Middeldorp, F J C M Klumper, E Lopriore, A K K Teunissen, M E Rijlaarsdam, D Oepkes, A D J Ten Harkel, M C Haak
OBJECTIVE: Severe right Ventricular Outflow Tract Obstruction (RVOTO) is a complication in recipient twins in Twin-to-Twin-Transfusion Syndrome (TTTS), which requires post-partum follow-up or treatment. The objective of our study was to evaluate pregnancy characteristics of neonates with RVOTO in complicated monochorionic twin pregnancies. In the TTTS cases we aimed to determine the incidence and to construct a prediction model for the development of RVOTO. METHODS: An observational cohort study of all complicated monochorionic twin pregnancies with a post-partum neonatal diagnosis of RVOTO was performed...
July 1, 2016: Ultrasound in Obstetrics & Gynecology
Rebeca Gregorio-Hernández, Ester Sanz-López, Alejandra Aguado-Del Hoyo, Gema Manrique-Martín, Juan Carlos De-Agustín, Manuel Sánchez-Luna
Introduction Congenital umbilical arteriovenous malformations (AVMs) are extremely rare. We present the first case of congenital umbilical AVM with feeding arteries originating not only from abdominal but also from the mammary arteries. Case Report A 34-week gestational age newborn was transferred to our hospital with a supraumbilical murmur. Abdominal Doppler ultrasound (US) showed a large vascular AVM, with multiple feeding arteries and several venous drainage structures to the umbilical vein and also a persistent ductus venosus...
April 2016: American Journal of Perinatology Reports
Valentina Stagnati, Cristina Zanardini, Anna Fichera, Giorgio Pagani, Ruben A Quintero, Rino Bellocco, Federico Prefumo
OBJECTIVE: The aim of this systematic review and meta-analysis was to assess the role of first trimester and early second trimester markers for the prediction of twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies. METHODS: MEDLINE, EMBASE and were searched from inception to April 2014. The MeSH term "fetofetal transfusion" was searched in combination with the phrases "predictive value", "sensitivity", "specificity", "false positive", "false negative", "screening", "accuracy" and "ROC"...
June 7, 2016: Ultrasound in Obstetrics & Gynecology
I Aditya, V Tat, A Sawana, A Mohamed, R Tuffner, T Mondal
Intrauterine growth restriction (IUGR) is a condition which has been difficult to assess at an early stage, resulting in the delivery of children who have poor genetic growth potential. Currently, IUGR classification is based upon the system of ultrasound biometry. Doppler velocimetry allows the measurement of hemodynamic flow of major fetal vessels, comparing the flow indices and patterns of normal and IUGR cases. In this review, the effectiveness of Doppler velocimetry in assessing blood flow in major vessels including the umbilical artery, ductus venosus, and middle cerebral artery was studied for both diagnostic and prognostic screening of IUGR...
May 18, 2016: Journal of Neonatal-perinatal Medicine
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