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https://www.readbyqxmd.com/read/29643787/optical-coherence-tomography-angiography-of-foveal-neovascularization-in-diabetic-retinopathy
#1
Konstantinos Andreanos, Tryfon Rotsos, George Kymionis, Chryssanthi Koutsandrea, Athanasios Kotsolis, Ioannis Ladas
Purpose: To report a case of foveal neovascularization in a patient with proliferative diabetic retinopathy as seen on optical coherence tomography angiography (OCT-A). Methods: Multimodal imaging was used for diagnostic investigation. Patient: A 61-year-old male with a 16-year history of insulin-dependent diabetes mellitus was referred to our medical retina department for examination and management. Meticulous fundus examination and multimodal imaging revealed proliferative diabetic retinopathy lesions, including neovascularization located in the foveal area...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29619531/autoantibodies-to-n-terminally-truncated-gad-improve-clinical-phenotyping-of-individuals-with-adult-onset-diabetes-action-lada-12
#2
Peter Achenbach, Mohammed I Hawa, Stephanie Krause, Vito Lampasona, Samuel T Jerram, Alistair J K Williams, Ezio Bonifacio, Anette G Ziegler, R David Leslie
AIMS/HYPOTHESIS: Adult-onset type 1 diabetes, in which the 65 kDa isoform of GAD (GAD65) is a major autoantigen, has a broad clinical phenotype encompassing variable need for insulin therapy. This study aimed to evaluate whether autoantibodies against N-terminally truncated GAD65 more closely defined a type 1 diabetes phenotype associated with insulin therapy. METHODS: Of 1114 participants with adult-onset diabetes from the Action LADA (latent autoimmune diabetes in adults) study with sufficient sera, we selected those designated type 1 (n = 511) or type 2 diabetes (n = 603) and retested the samples in radiobinding assays for human full-length GAD65 autoantibodies (f-GADA) and N-terminally truncated (amino acids 96-585) GAD65 autoantibodies (t-GADA)...
April 4, 2018: Diabetologia
https://www.readbyqxmd.com/read/29589073/overweight-obesity-and-the-risk-of-lada-results-from-a-swedish-case-control-study-and-the-norwegian-hunt-study
#3
Rebecka Hjort, Emma Ahlqvist, Per-Ola Carlsson, Valdemar Grill, Leif Groop, Mats Martinell, Bahareh Rasouli, Anders Rosengren, Tiinamaija Tuomi, Bjørn Olav Åsvold, Sofia Carlsson
AIMS/HYPOTHESIS: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. METHODS: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008)...
March 27, 2018: Diabetologia
https://www.readbyqxmd.com/read/29518492/lower-mortality-and-cardiovascular-event-rates-in-patients-with-latent-autoimmune-diabetes-in-adults-lada-as-compared-with-type-2-diabetes-and-insulin-deficient-diabetes-a-cohort-study-of-4-368-patients
#4
Mette Wod, Reimar W Thomsen, Lars Pedersen, Knud B Yderstraede, Henning Beck-Nielsen, Kurt Højlund
BACKGROUND: Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovascular outcomes in patients with LADA, type 2 diabetes mellitus (T2D), and insulin deficient diabetes (IDD). METHODS: We conducted a cohort study of 4,368 adults with diabetes referred to the Department of Endocrinology, Odense University Hospital, Denmark, between 1997 and 2012...
March 5, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29487566/islet-cell-associated-autoantibodies-and-c-peptide-levels-in-patients-with-diabetes-and-symptoms-of-gastroparesis
#5
Elias S Siraj, Carol Homko, Laura A Wilson, Patrick May, Ajay D Rao, Jorge Calles, Gianrico Farrugia, William L Hasler, Kenneth L Koch, Linda Nguyen, William J Snape, Thomas L Abell, Irene Sarosiek, Richard W McCallum, Pankaj J Pasricha, John Clarke, James Tonascia, Frank Hamilton, Henry P Parkman
Introduction: Individuals with diabetes are at increased risk for complications, including gastroparesis. Type 1 diabetes mellitus (T1DM) is an autoimmune disorder resulting in decreased beta-cell function. Glutamic acid decarboxylase-65 antibody (GADA) is the most commonly used test to assess autoimmunity while C-peptide level is used to assess beta-cell function. Patients with type 2 diabetes mellitus (T2DM), who are GADA positive, are labeled latent autoimmune diabetes in adults (LADA)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29220505/metabolic-characteristics-of-recently-diagnosed-adult-onset-autoimmune-diabetes-mellitus
#6
Oana P Zaharia, Pavel Bobrov, Klaus Strassburger, Kálmán Bódis, Yanislava Karusheva, Michaela Scholz, Daniel F Markgraf, Volker Burkart, Nanette C Schloot, Karsten Müssig, Julia Szendroedi, Michael Roden
Context and Objective: Among patients diagnosed with type 2 diabetes, autoimmune diabetes often remains undetected. Metabolic features of these patients are insufficiently characterized at present. Design, Setting, and Patients: This study compared age- and sex-matched adult (aged 41 to 62 years) humans with recent-onset diabetes: patients positive for antibodies against glutamic acid decarboxylase (GAD) and/or cytoplasmic islet-cell antigen with an insulin-free period of >6 months [antibody positive/insulin negative (ab+/ins-); previously termed latent autoimmune diabetes of adults], type 1 diabetes [antibody positive/insulin positive (ab+/ins+)], and type 2 diabetes [antibody negative/insulin negative (ab-/ins-)], as well as glucose-tolerant humans (controls) of the German Diabetes Study (n = 41/group)...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29171766/bioanalytical-methods-for-the-detection-of-antidiabetic-drugs-a-review
#7
Mariana Millan Fachi, Letícia Paula Leonart, Flávia Lada Degaut Pontes, Raquel de Oliveira Vilhena, Letícia Bonancio Cerqueira, Roberto Pontarolo
Type 2 diabetes mellitus, a disease which prevalence has been progressively increasing worldwide, is characterized by chronic hyperglycemia resulting from the combination of inappropriate insulin secretion and/or resistance to insulin action. If left uncontrolled, diabetes is associated with complications such as dysfunction and failure of various organs, and even premature death. Along with lifestyle-modification strategies, several classes of oral antidiabetic agents can be employed for glycemic control. Thus, therapeutic drug monitoring of these drugs is essential to maintain appropriate treatment...
December 2017: Bioanalysis
https://www.readbyqxmd.com/read/29067979/peripheral-blood-mononuclear-cells-of-patients-with-latent-autoimmune-diabetes-secrete-higher-levels-of-pro-anti-inflammatory-cytokines-compared-to-those-with-type-1-diabetes-mellitus-following-in-vitro-stimulation-with-%C3%AE-cell-autoantigens
#8
Darshan Badal, Rajendra Kumar, Mahinder Paul, Devi Dayal, Anil Bhansali, Sanjay Kumar Bhadada, Rajesh Kumar, Naresh Sachdeva
BACKGROUND & OBJECTIVES: Type-1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA) share similar pathological features but differ in age of onset and progression. There is a scarcity of information on differences in CD4+ T-cell responses, particularly, cytokine secretion, between the two forms of autoimmune diabetes. Here proliferative potential and concentration of pro- and anti-inflammatory cytokines secreted by peripheral blood mononuclear cells (PBMCs) of T1DM and LADA patients were compared, after in vitro stimulation with β-cell autoantigens...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29062603/decreased-quality-of-life-and-treatment-satisfaction-in-patients-with-latent-autoimmune-diabetes-of-the-adult
#9
Minerva Granado-Casas, Montserrat Martínez-Alonso, Nuria Alcubierre, Anna Ramírez-Morros, Marta Hernández, Esmeralda Castelblanco, Joan Torres-Puiggros, Didac Mauricio
OBJECTIVES: Our main aim was to assess the quality of life (QoL) and treatment satisfaction (TS) of subjects with LADA (latent autoimmune diabetes of the adult) and compare these measures with those of patients with other diabetes types, i.e., type 1 (T1DM) and type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study with a total of 48 patients with LADA, 297 patients with T2DM and 124 with T1DM. The Audit of Diabetes-Dependent Quality of Life (ADDQoL-19) questionnaire and the Diabetes Treatment Satisfaction Questionnaire (DTSQ) were administered...
2017: PeerJ
https://www.readbyqxmd.com/read/29040050/latent-autoimmune-diabetes-in-adults-in-north-indian-region-assessment-of-%C3%AE-cell-function-metabolic-and-immunological-features
#10
Alok Kumar, Alberto de Leiva
BACKGROUND: We undertook a study to assess β-cell function, metabolic and immunological features of patients with latent autoimmune diabetes in adults (LADA) and investigate heterogeneity within LADA based on low and high glutamic acid decarboxylase autoantibodies (GADA) titers. METHODS: A total of 139 patients with adult-onset diabetes were examined cross-sectionally in the National capital region of Northern India. Medical history of all subjects was reviewed with the aim of collecting clinical data...
December 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29026609/ketosis-prone-diabetes-and-sle-co-presenting-in-an-african-lady-with-previous-gestational-diabetes
#11
S Hussain, S Keat, S V Gelding
We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28987750/metabolic-risk-profiles-in-diabetes-stratified-according-to-age-at-onset-islet-autoimmunity-and-fasting-c-peptide
#12
Mette Wod, Knud B Yderstræde, Ulrich Halekoh, Henning Beck-Nielsen, Kurt Højlund
OBJECTIVE: Islet autoimmunity, age at onset and time to insulin treatment are often used to define subgroups of diabetes. However, the latter criterion is not clinical useful. Here, we examined whether an unbiased stratification of diabetes according to age at onset, fasting C-peptide and GAD autoantibodies (GADab) defines groups with differences in glycaemic control and markers of cardiometabolic risk. DESIGN AND METHODS: A cohort of 4374 adults with relatively newly diagnosed diabetes referred to a Danish hospital during 1997-2012 was stratified according to age at onset above or below 30 years, fasting C-peptide above or below 300 pmol/l (CPEPhigh or CPEPlow ), and presence or absence of GADab (GADpos or GADneg )...
December 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28929327/possible-long-term-efficacy-of-sitagliptin-a-dipeptidyl-peptidase-4-inhibitor-for-slowly-progressive-type-1-diabetes-spiddm-in-the-stage-of-non-insulin-dependency-an-open-label-randomized-controlled-pilot-trial-span-s
#13
Takuya Awata, Akira Shimada, Taro Maruyama, Yoichi Oikawa, Nobuyuki Yasukawa, Susumu Kurihara, Yumi Miyashita, Masako Hatano, Yuichi Ikegami, Masafumi Matsuda, Masataka Niwa, Youichiro Kazama, Shoichiro Tanaka, Tetsuro Kobayashi
INTRODUCTION: We tested the hypothesis that dipeptidyl peptidase-4 (DPP-4) inhibitors are effective in preserving the β-cell function for long-term periods in patients with slowly progressive type 1 diabetes (SPIDDM) or latent autoimmune diabetes in adults (LADA). METHODS: In the present open-label, randomized, controlled trial, 14 non-insulin-requiring diabetic patients with glutamic acid decarboxylase autoantibodies (GADAb) were randomly assigned to receive either sitagliptin (S group) or pioglitazone (P group)...
October 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28885622/adult-onset-autoimmune-diabetes-current-knowledge-and-implications-for-management
#14
REVIEW
Raffaella Buzzetti, Simona Zampetti, Ernesto Maddaloni
Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a reduced genetic load, a less intensive autoimmune process and a mild metabolic decompensation at onset compared with young-onset type 1 diabetes mellitus (T1DM). The majority of patients with adult-onset autoimmune diabetes do not require insulin treatment for at least 6 months after diagnosis. Such patients are defined as having latent autoimmune diabetes in adults (LADA), which is distinct from classic adult-onset T1DM. The extensive heterogeneity of adult-onset autoimmune diabetes is apparent beyond the distinction between classic adult-onset T1DM and LADA...
November 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28669512/family-history-of-type-1-and-type-2-diabetes-and-risk-of-latent-autoimmune-diabetes-in-adults-lada
#15
R Hjort, L Alfredsson, T Andersson, P-O Carlsson, V Grill, L Groop, M Martinell, B Rasouli, P Storm, T Tuomi, S Carlsson
BACKGROUND: A family history of diabetes (FHD) is a strong predictor of diabetes risk, yet has rarely been investigated in latent autoimmune diabetes in adults (LADA). This study therefore investigated the risk of LADA and type 2 diabetes (T2D) in relation to FHD, taking into account the type of diabetes in relatives. METHODS: Data from a population-based study were used, including incident cases of LADA [glutamic acid decarboxylase antibody (GADA)-positive, n=378] and T2D (GADA-negative, n=1199), and their matched controls (n=1484)...
June 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28544229/clinical-heterogeneity-of-type-1-diabetes-t1d-found-in-asia
#16
REVIEW
Yongsoo Park, Kupper A Wintergerst, Zhiguang Zhou
Diabetes mellitus among young patients in Asia is caused by a complex set of factors. Although type 1 diabetes (T1D) remains the most common form of diabetes in children, the recent unabated increase in obesity has resulted in the emergence of type 2 diabetes (T2D) as a new type of diabetes among adolescents and young adults. In addition to the typical autoimmune type 1 diabetes (T1aD) and T2D patients, there is a variable incidence of cases of non-autoimmune types of T1D associated with insulin deficiency (T1bD)...
October 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28514308/emotional-exhaustion-induced-latent-autoimmune-diabetes-in-adults-in-a-young-lady-a-care-compliant-case-report
#17
Yin-Ling Chen, Yong-Chao Qiao, Xin-Nan Song, Wei Ling, Hai-Lu Zhao, Xiao-Xi Zhang
RATIONALE: Latent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes. PATIENT CONCERNS: A young woman suffered an emotional exhaustion-induced LADA, showing asthenia, polydipsia, polyuria, and visible weight loss. The patient emotionally ended a 14-year romantic relationship, leading to the emotional flooding...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28440768/clinical-and-metabolic-profile-of-patients-with-latent-autoimmune-diabetes-in-adults-in-specialized-care-in-madrid
#18
Alfonso Arranz Martín, Edurne Lecumberri Pascual, Miguel Ángel Brito Sanfiel, Víctor Andía Melero, Lia Nattero Chavez, Iván Sánchez López, Gloria Cánovas Molina, Francisco Arrieta Blanco, Noemí González Perez Del Villar
OBJECTIVE: To report the clinical characteristics of patients with latent autoimmune diabetes in adults (LADA), and to ascertain their metabolic control and associated chronic complications. METHODS: Patients with DM attending specialized medical care in Madrid who met the following criteria: age at diagnosis of DM >30years, initial insulin independence for at least 6months and positive GAD antibodies were enrolled. Clinical profiles, data on LADA diagnosis, associated autoimmunity, C-peptide levels, therapeutic regimen, metabolic control, and presence of chronic complications were analyzed...
January 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28438156/relative-contribution-of-type-1-and-type-2-diabetes-loci-to-the-genetic-etiology-of-adult-onset-non-insulin-requiring-autoimmune-diabetes
#19
Rajashree Mishra, Alessandra Chesi, Diana L Cousminer, Mohammad I Hawa, Jonathan P Bradfield, Kenyaita M Hodge, Vanessa C Guy, Hakon Hakonarson, Didac Mauricio, Nanette C Schloot, Knud B Yderstræde, Benjamin F Voight, Stanley Schwartz, Bernhard O Boehm, Richard David Leslie, Struan F A Grant
BACKGROUND: In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as 'latent autoimmune diabetes in adults' (LADA). In this study, we investigated established type 1 diabetes (T1D) and type 2 diabetes (T2D) genetic loci in a large cohort of LADA cases to assess where LADA is situated relative to these two well-characterized, classic forms of diabetes. METHODS: We tested the association of T1D and T2D GWAS-implicated loci in 978 LADA cases and 1057 non-diabetic controls of European ancestry using a linear mixed model...
April 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28414668/autoimmune-diabetes-presented-with-diabetic-ketoacidosis-induced-by-immunotherapy-in-an-adult-with-melanoma
#20
A A Alzenaidi, J Dendy, L Rejjal
INTRODUCTION: Immunotherapy has been approved for treatment of melanoma. Autoimmune endocrinopathies have been reported in trials involving immunotherapy but autoimmune diabetes has not been definitively linked to them. Here we describe a case of autoimmune diabetes presenting with DKA after receiving combined immunotherapy with anti-CTLA4 and anti-PD1 monoclonal antibodies. CASE: A 47year old gentleman with metastatic melanoma presented to our institution with confusion, abdominal pain and decreased oral intake...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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