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https://www.readbyqxmd.com/read/28918356/what-is-the-price-for-the-duchenne-gait-pattern-in-patients-with-cerebral-palsy
#1
Firooz Salami, Mirjam Niklasch, Britta K Krautwurst, Thomas Dreher, Sebastian I Wolf
Duchenne gait is characterized by trunk lean towards the affected stance limb with the pelvis stable or elevated on the swinging limb side during single limb stance phase. We assessed the relationship between hip abduction moments and trunk kinetics in patients with cerebral palsy showing excessive lateral trunk motion. Data of 18 subjects with bilateral spastic cerebral palsy (CP) and 20 aged matched typically developing subjects (TD) were collected retrospectively. Criteria for patient selection were barefoot walking without aid presenting with excessive lateral trunk motion...
September 7, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28918063/a-pca-based-method-for-determining-craniofacial-relationship-and-sexual-dimorphism-of-facial-shapes
#2
Wuyang Shui, Mingquan Zhou, Steve Maddock, Taiping He, Xingce Wang, Qingqiong Deng
Previous studies have used principal component analysis (PCA) to investigate the craniofacial relationship, as well as sex determination using facial factors. However, few studies have investigated the extent to which the choice of principal components (PCs) affects the analysis of craniofacial relationship and sexual dimorphism. In this paper, we propose a PCA-based method for visual and quantitative analysis, using 140 samples of 3D heads (70 male and 70 female), produced from computed tomography (CT) images...
September 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28917842/multi-scale-simulations-of-biological-systems-using-the-opep-coarse-grained-model
#3
Fabio Sterpone, Sébastien Doutreligne, Thanh Thuy Tran, Simone Melchionna, Marc Baaden, Phuong H Nguyen, Philippe Derreumaux
Biomolecules are complex machines that are optimized by evolution to properly fulfill or contribute to a variety of biochemical tasks in the cellular environment. Computer simulations based on quantum mechanics and atomistic force fields have been proven to be a powerful microscope for obtaining valuable insights into many biological, physical, and chemical processes. Many interesting phenomena involve, however, a time scale and a number of degrees of freedom, notably if crowding is considered, that cannot be explored at an atomistic resolution...
September 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917677/interventional-correction-of-sinus-venosus-atrial-septal-defect-and-partial-anomalous-pulmonary-venous-drainage-procedural-planning-using-3d-printed-models
#4
Mari Nieves Velasco Forte, Nick Byrne, Israel Valverde, Gorka Gomez Ciriza, Antony Hermuzi, Pimpak Prachasilchai, Gur Mainzer, Kuberan Pushparajah, Markus Henningsson, Tarique Hussain, Shakeel Qureshi, Eric Rosenthal
No abstract text is available yet for this article.
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28917643/a-novel-3-dimensional-electromagnetic-guidance-system-increases-intraoperative-microwave-antenna-placement-accuracy
#5
Amit V Sastry, Jacob H Swet, Keith J Murphy, Erin H Baker, Dionisios Vrochides, John B Martinie, Iain H McKillop, David A Iannitti
BACKGROUND: Failure to locate lesions and accurately place microwave antennas can lead to incomplete tumor ablation. The Emprint™ SX Ablation Platform employs real-time 3D-electromagnetic spatial antenna tracking to generate intraoperative laparoscopic antenna guidance. We sought to determine whether Emprint™ SX affected time/accuracy of antenna-placement in a laparoscopic training model. METHODS: Targets (7-10 mm) were set in agar within a laparoscopic training device...
September 13, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28917579/microcirculation-in-the-murine-liver-a-computational-fluid-dynamic-model-based-on-3d-reconstruction-from-in-vivo-microscopy
#6
Monica Piergiovanni, Elena Bianchi, Giada Capitani, Irene Li Piani, Lucia Ganzer, Luca G Guidotti, Matteo Iannacone, Gabriele Dubini
The liver is organized in hexagonal functional units - termed lobules - characterized by a rather peculiar blood microcirculation, due to the presence of a tangled network of capillaries - termed sinusoids. A better understanding of the hemodynamics that governs liver microcirculation is relevant to clinical and biological studies aimed at improving our management of liver diseases and transplantation. Herein, we built a CFD model of a 3D sinusoidal network, based on in vivo images of a physiological mouse liver obtained with a 2-photon microscope...
September 2, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28917147/combined-in-silico-approaches-for-the-identification-of-novel-inhibitors-of-human-islet-amyloid-polypeptide-hiapp-fibrillation
#7
Palak Patel, Krupali Parmar, Vivek K Vyas, Dhaval Patel, Mili Das
Human islet amyloid polypeptide (hIAPP) is a natively unfolded polypeptide hormone of glucose metabolism, which is co-secreted with insulin by the β-cells of the pancreas. In patients with type 2 diabetes, IAPP forms amyloid fibrils because of diabetes-associated β-cells dysfunction and increasing fibrillation, in turn, lead to failure of secretory function of β-cells. This provides a target for the discovery of small organic molecules against protein aggregation diseases. However, the binding mechanism of these molecules with monomers, oligomers and fibrils to inhibit fibrillation is still an open question...
September 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28916961/practical-computational-toolkits-for-dendrimers-and-dendrons-structure-design
#8
Nuno Martinho, Liana C Silva, Helena F Florindo, Steve Brocchini, Teresa Barata, Mire Zloh
Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures...
September 15, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28916912/morphological-changes-in-tibial-tunnels-after-anatomic-anterior-cruciate-ligament-reconstruction-with-hamstring-tendon-graft
#9
Tomoki Ohori, Tatsuo Mae, Konsei Shino, Yuta Tachibana, Kazuomi Sugamoto, Hideki Yoshikawa, Ken Nakata
BACKGROUND: Three-dimensional (3D) reconstructed computed tomography (CT) is crucial for the reliable and accurate evaluation of tunnel enlargement after anterior cruciate ligament (ACL) reconstruction. The purposes of this study were to evaluate the tibial tunnel enlargement at the tunnel aperture and inside the tunnel and to clarify the morphological change at the tunnel footprint 1 year after the anatomic triple-bundle (ATB) ACL reconstruction using 3D CT models. METHODS: Eighteen patients with unilateral ACL rupture were evaluated...
September 15, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28916844/left-sided-breast-cancer-and-risks-of-secondary-lung-cancer-and-ischemic-heart-disease-effects-of-modern-radiotherapy-techniques
#10
Stefanie Corradini, Hendrik Ballhausen, Helmut Weingandt, Philipp Freislederer, Stephan Schönecker, Maximilian Niyazi, Cristoforo Simonetto, Markus Eidemüller, Ute Ganswindt, Claus Belka
PURPOSE: Modern breast cancer radiotherapy techniques, such as respiratory-gated radiotherapy in deep-inspiration breath-hold (DIBH) or volumetric-modulated arc radiotherapy (VMAT) have been shown to reduce the high dose exposure of the heart in left-sided breast cancer. The aim of the present study was to comparatively estimate the excess relative and absolute risks of radiation-induced secondary lung cancer and ischemic heart disease for different modern radiotherapy techniques. METHODS: Four different treatment plans were generated for ten computed tomography data sets of patients with left-sided breast cancer, using either three-dimensional conformal radiotherapy (3D-CRT) or VMAT, in free-breathing (FB) or DIBH...
September 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28916398/in-vivo-analysis-of-sternal-angle-sternal-and-sternocostal-kinematics-in-supine-humans-during-breathing
#11
Benoît Beyer, Véronique Feipel, Victor Sholukha, Laurence Chèze, Serge Van Sint Jan
This paper aims at contributing to the understanding of the combination of in vivo sternum displacement, sternal angle variations and sternocostal joints (SCJ) kinematics of the seven first rib pairs over the inspiratory capacity (IC). Retrospective codified spiral-CT data obtained at total lung capacity (TLC), middle of inspiratory capacity (MIC) and at functional residual capacity (FRC) were used to compute kinematic parameters of the bones and joints of interest in a sample of 12 asymptomatic subjects. 3D models of rib, thoracic vertebra, manubrium and sternum were processed to determine anatomical landmarks (ALs) on each bone...
September 1, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28916286/toxicology-studies-of-primycin-sulphate-using-a-three-dimensional-3d-in-vitro-human-liver-aggregate-model
#12
Ágota Pénzes, Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Zsanett A Péteri, Judit Bovári-Biri, Csaba Fekete, György Miskei, Krisztián Kvell, Judit E Pongrácz
Primycin-sulphate is a highly effective compound against Gram (G) positive bacteria. It has a potentially synergistic effect with vancomycin and statins which makes primycin-sulphate a potentially very effective preparation. Primycin-sulphate is currently used exclusively in topical preparations such as in in vitro animal hepatocyte and neuromuscular junction studies (in mice, rats, snakes, frogs) as well as in in vitro human red blood cell experiments. During these studies, the use of primycin-sulphate resulted in reduced cellular membrane integrity and modified ion channel activity...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28916243/feasibility-and-accuracy-of-automated-software-for-transthoracic-three-dimensional-left-ventricular-volume-and-function-analysis-comparisons-with-two-dimensional-echocardiography-three-dimensional-transthoracic-manual-method-and-cardiac-magnetic-resonance-imaging
#13
Gloria Tamborini, Concetta Piazzese, Roberto M Lang, Manuela Muratori, Elisa Chiorino, Massimo Mapelli, Laura Fusini, Sarah Ghulam Ali, Paola Gripari, Gianluca Pontone, Daniele Andreini, Mauro Pepi
BACKGROUND: Recently, a new automated software package (HeartModel) was developed to obtain three-dimensional (3D) left ventricular (LV) volumes using a model-based algorithm (MBA) with a "one-button" simple system and user-adjustable slider. The aims of this study were to verify the feasibility and accuracy of the MBA in comparison with other commonly used imaging techniques in a large unselected population, to evaluate possible accuracy improvements of free operator border adjustments or changes of the slider's default position, and to identify differences in method accuracy related to specific pathologies...
September 12, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28916173/a-new-anatomical-view-on-the-vector-cardiogram-the-mean-temporal-spatial-isochrones
#14
Peter M van Dam
AIM: This proof of principle study aims to show the direct relationship between cardiac anatomy and the mean cardiac activation path as captured by the 12 lead ECG derived mean temporal-spatial isochrones (mean TSI) path. METHODS: To obtain the mean TSI signal a vector cardiographic (VCG) signal is constructed from the 12 lead ECG. The construction of the VCG signal uses a model of the heart and torso with patient specific electrode extracted from a 3D photo. The propagation of the activation through the heart is captured by estimating the mean of a cardiac activation isochrone using this VCG signal...
August 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28915670/prostate-cancer-diagnosis-using-epigenetic-biomarkers-3d-high-content-imaging-and-probabilistic-cell-by-cell-classifiers
#15
Darko Stefanovski, George Tang, Kolja Wawrowsky, Raymond C Boston, Nils Lambrecht, Jian Tajbakhsh
BACKGROUND: Prostate cancer (PCa) management can benefit from novel concepts/biomarkers for reducing the current 20-30% chance of false-negative diagnosis with standard histopathology of biopsied tissue. METHOD: We explored the potential of selected epigenetic markers in combination with validated histopathological markers, 3D high-content imaging, cell-by-cell analysis, and probabilistic classification in generating novel detailed maps of biomarker heterogeneity in patient tissues, and PCa diagnosis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915413/transmission-electron-microscopy-studies-and-modeling-of-3d-reciprocal-space-of-%C3%AF-forming-alloy
#16
Alphy George, Vinayak Sharma, R Divakar, M Sabeena, E Mohandas
Initial stage of ω phase formation and associated anomalous features that appear in diffraction patterns of a metastable β transition metal alloy have been investigated in this study with the aid of transmission electron microscopy, simulation and modeling. The paper explores discrete features that emerge in selected area diffraction patterns of quenched Ti-15wt%Mo alloy and analyzes the correlation between ω reflections and diffuse arcs by considering all variants of ω phase as per the formation kinetics of ω phase in β matrix while quenching...
September 12, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28915407/differentiation-and-sarcomere-formation-in-skeletal-myocytes-directly-prepared-from-human-induced-pluripotent-stem-cells-using-a-sphere-based-culture
#17
Saowanee Jiwlawat, Eileen Lynch, Jennifer Glaser, Ivy Smit-Oistad, Jeremy Jeffrey, Jonathan M Van Dyke, Masatoshi Suzuki
Human induced-pluripotent stem cells (iPSCs) are a promising resource for propagation of myogenic progenitors. Our group recently reported a unique protocol for the derivation of myogenic progenitors directly (without genetic modification) from human pluripotent cells using free-floating spherical culture. Here we expand our previous efforts and attempt to determine how differentiation duration, culture surface coatings, and nutrient supplements in the medium influence progenitor differentiation and formation of skeletal myotubes containing sarcomeric structures...
August 1, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28915356/real-time-apoptosis-and-viability-high-throughput-screening-of-3d-multicellular-tumor-spheroids-using-the-celigo-image-cytometer
#18
Sarah Kessel, Scott Cribbes, Surekha Bonasu, Jean Qiu, Leo Li-Ying Chan
Three-dimensional tumor spheroid models have been increasingly used to investigate and characterize cancer drug compounds. Previously, the Celigo image cytometer has demonstrated its utility in a high-throughput screening manner for evaluating potential drug candidates in a 3D multicellular tumor spheroid (MCTS) primary screen. In addition, we have developed real-time kinetic caspase 3/7 apoptosis and propidium iodide viability 3D MCTS assays, both of which can be used in a secondary screen to better characterize the hit compounds...
September 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28914982/production-of-accurate-skeletal-models-of-domestic-animals-using-three-dimensional-scanning-and-printing-technology
#19
Fangzheng Li, Chunying Liu, Xuexiong Song, Yanjun Huan, Shansong Gao, Zhongling Jiang
Access to adequate anatomical specimens can be an important aspect in learning the anatomy of domestic animals. In this study, the authors utilized a structured light scanner and fused deposition modeling (FDM) printer to produce highly accurate animal skeletal models. First, various components of the bovine skeleton, including the femur, the fifth rib, and the sixth cervical (C6) vertebra were used to produce digital models. These were then used to produce 1:1 scale physical models with the FDM printer. The anatomical features of the digital models and three-dimensional (3D) printed models were then compared with those of the original skeletal specimens...
September 15, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28914318/analytical-numerical-and-experimental-studies-of-viscoelastic-effects-on-the-performance-of-soft-piezoelectric-nanocomposites
#20
Jing Li, Zhiren Zhu, Lichen Fang, Shu Guo, Ugur Erturun, Zeyu Zhu, James E West, Somnath Ghosh, Sung Hoon Kang
Piezoelectric composite (p-NC) made of a polymeric matrix and piezoelectric nanoparticles with conductive additives is an attractive material for many applications. As the matrix of p-NC is made of viscoelastic materials, both elastic and viscous characteristics of the matrix are expected to contribute to the piezoelectric response of p-NC. However, there is limited understanding of how viscoelasticity influences the piezoelectric performance of p-NC. Here we combined analytical and numerical analyses with experimental studies to investigate effects of viscoelasticity on piezoelectric performance of p-NC...
September 15, 2017: Nanoscale
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