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https://www.readbyqxmd.com/read/28806634/a-correlation-based-bullet-identification-method-using-empirical-mode-decomposition
#1
Saeed Bigdeli, Hamed Danandeh, Mohsen Ebrahimi Moghaddam
The striations on bullet surface are 3D micro structures formed when a bullet is forcing its way out of barrel. Each barrel leaves individual striation patterns on bullets. Hence, the striation information of bullets is helpful for firearm identification. Common automatic identification methods process these images using linear time invariant (LTI) filters based on correlation. These methods do not consider the sensitivity of correlation based comparisons to nonlinear baseline drifts. The striations are undeniably random unique micro structures caused by random non-model-based imperfections in the tools used in rifling process, therefore any characteristic profile that is extracted from a bullet image is statistically non-stationary...
August 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28805850/dispersible-oxygen-microsensors-map-oxygen-gradients-in-three-dimensional-cell-cultures
#2
Sasha Cai Lesher-Pérez, Ge-Ah Kim, Chuan-Hsien Kuo, Brendan M Leung, Sanda Mong, Taisuke Kojima, Christopher Moraes, M D Thouless, Gary D Luker, Shuichi Takayama
Phase fluorimetry, unlike the more commonly used intensity-based measurement, is not affected by differences in light paths from culture vessels or by optical attenuation through dense 3D cell cultures and hydrogels thereby minimizing dependence on signal intensity for accurate measurements. This work describes the use of phase fluorimetry on oxygen-sensor microbeads to perform oxygen measurements in different microtissue culture environments. In one example, cell spheroids were observed to deplete oxygen from the cell-culture medium filling the bottom of conventional microwells within minutes, whereas oxygen concentrations remained close to ambient levels for several days in hanging-drop cultures...
August 14, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28805689/visual-servoing-for-an-autonomous-hexarotor-using-a-neural-network-based-pid-controller
#3
Carlos Lopez-Franco, Javier Gomez-Avila, Alma Y Alanis, Nancy Arana-Daniel, Carlos Villaseñor
In recent years, unmanned aerial vehicles (UAVs) have gained significant attention. However, we face two major drawbacks when working with UAVs: high nonlinearities and unknown position in 3D space since it is not provided with on-board sensors that can measure its position with respect to a global coordinate system. In this paper, we present a real-time implementation of a servo control, integrating vision sensors, with a neural proportional integral derivative (PID), in order to develop an hexarotor image based visual servo control (IBVS) that knows the position of the robot by using a velocity vector as a reference to control the hexarotor position...
August 12, 2017: Sensors
https://www.readbyqxmd.com/read/28804489/normalized-synergy-predicts-that-cd8-co-receptor-contribution-to-t-cell-receptor-tcr-and-pmhc-binding-decreases-as-tcr-affinity-increases-in-human-viral-specific-t-cells
#4
Chad M Williams, Alexandra A Schonnesen, Shu-Qi Zhang, Ke-Yue Ma, Chenfeng He, Tori Yamamoto, S Gail Eckhardt, Christopher A Klebanoff, Ning Jiang
The discovery of naturally occurring T cell receptors (TCRs) that confer specific, high-affinity recognition of pathogen and cancer-associated antigens remains a major goal in cellular immunotherapies. The contribution of the CD8 co-receptor to the interaction between the TCR and peptide-bound major histocompatibility complex (pMHC) has previously been correlated with the activation and responsiveness of CD8(+) T cells. However, these studies have been limited to model systems of genetically engineered hybridoma TCRs or transgenic mouse TCRs against either a single epitope or an array of altered peptide ligands...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28803903/structured-illumination-microscopy-reveals-actin-i-localization-in-discreet-foci-in-plasmodium-berghei-gametocytes
#5
Chiara Curra, Paul J McMillan, Lefteris Spanos, Vanessa Mollard, Elena Deligianni, Geoffrey McFadden, Leann Tilley, Inga Siden-Kiamos
Actin has important roles in Plasmodium parasites but its exact function in different life stages is not yet fully elucidated. Here we report the localization of ubiquitous actin I in gametocytes of the rodent model parasite P. berghei. Using an antibody specifically recognizing F-actin and deconvolution microscopy we detected actin I in a punctate pattern in gametocytes. 3D-Structured Illumination Microscopy which allows sub-diffraction limit imaging resolved the signal into structures of less than 130 nm length...
August 10, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28803858/in-silico-investigations-of-the-functional-impact-of-kcna5-mutations-on-atrial-mechanical-dynamics
#6
Haibo Ni, Ismail Adeniran, Henggui Zhang
A recent study has identified six novel genetic variations (D322H, E48G, A305T, D469E, Y155C, P488S) in KCNA5 (encoding Kv1.5 which carries the atrial-specific ultra-rapid delayed rectifier current, IKur) in patients with early onset of lone atrial fibrillation. These mutations are distinctive, resulting in either gain-of-function (D322H, E48G, A305T) or loss-of-function (D469E, Y155C, P488S) of IKur channels. Though affecting potassium channels, they may modulate the cellular active force and therefore atrial mechanical functions, which remains to be elucidated...
August 10, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28803852/dynamic-feet-distance-a-new-functional-assessment-during-treadmill-locomotion-in-normal-and-thoracic-spinal-cord-injured-rats
#7
Camila Cardoso Diogo, Luís Maltez da Costa, José Eduardo Pereira, Vítor Filipe, Pedro Alexandre Couto, Luís G Magalhães, Stefano Geuna, Paulo A Armada-da-Silva, Ana Colette Maurício, Artur Severo Varejão
Of all the detrimental effects of spinal cord injury (SCI), one of the most devastating is the disruption of the ability to perform functional movement. Very little is known on the recovery of hindlimb joint kinematics after clinically-relevant contusive thoracic lesion in experimental animal models. A new functional assessment instrument, the dynamic feet distance (DFD) was used to describe the distance between the two feet throughout the gait cycle in normal and affected rodents. The purpose of this investigation was the evaluation and characterization of the DFD during treadmill locomotion in normal and T9 contusion injured rats, using three-dimensional (3D) instrumented gait analysis...
August 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28803627/bubble-bubble-interactions-in-a-2d-foam-close-to-the-wet-limit
#8
REVIEW
D Weaire, R Höhler, S Hutzler
Following the general approach of Morse and Witten for the deformation of a bubble in contact with neighbouring bubbles, we develop a model for contacting bubbles in two dimensions which can be solved analytically. The force-displacement relations are derived by elementary methods; unlike the case of 3d, no logarithmic factors arise in two dimensions. We also discuss the case of a uniform compression of a symmetric foam structure; the (osmotic) compressibility depends on the number of contacts, as was shown in earlier work by Lacasse et al...
July 13, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28803216/3d-2d-registration-with-superabundant-vessel-reconstruction-for-cardiac-resynchronization-therapy
#9
Daniel Toth, Maria Panayiotou, Alexander Brost, Jonathan M Behar, Christopher A Rinaldi, Kawal S Rhode, Peter Mountney
A key component of image guided interventions is the registration of preoperative and intraoperative images. Classical registration approaches rely on cross-modality information; however, in modalities such as MRI and X-ray there may not be sufficient cross-modality information. This paper proposes a fundamentally different registration approach which uses adjacent anatomical structures with superabundant vessel reconstruction and dynamic outlier rejection. In the targeted clinical scenario of cardiac resynchronization therapy (CRT) delivery, preoperative, non contrast-enhanced, MRI is registered to intraoperative, contrasted X-ray fluoroscopy...
August 5, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28803112/in-vivo-documentation-of-shape-and-position-changes-of-mri-visible-mesh-placed-in-rectovaginal-septum
#10
Urbankova Iva, Sindhwani Nikhil, Callewaert Geertje, Turri Alice, Rinkijevic Rita, Hympanova Lucie, Feola Andrew, Deprest Jan
BACKGROUND AND OBJECTIVE: Large deformations in synthetic meshes used in pelvic organ prolapse surgery may lead to suboptimal support for the underlying tissue, graft-related complications as well as recurrence. Our aim was to quantify in vivo longitudinal changes in mesh shape and geometry in a large animal model. We compare two commonly used mesh shapes, armed and flat, that are differently affixed. The secondary outcomes were active and passive biomechanical properties. METHODS: A total of 18 animals were used...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28802745/circumferential-bone-grafting-around-an-absorbable-gelatin-sponge-core-reduced-the-amount-of-grafted-bone-in-the-induced-membrane-technique-for-critical-size-defects-of-long-bones
#11
Jae-Woo Cho, Jinil Kim, Won-Tae Cho, Jin-Kak Kim, Jong Hoon Song, Hyung-Jin Kim, Alain C Masquelet, Jong-Keon Oh
OBJECTIVES: The objectives of the study were to introduce a circumferential bone graft around an absorbable gelatin sponge core using an induced membrane technique, to assess its ability to reduce the required amount of graft and to maintain the bone graft, and to evaluate the clinical outcomes in the management of critical-size bone defects. PATIENTS AND METHODS: Circumferential bone grafting using a staged induced membrane technique for managing critical-size bone defects was performed in 21 patients...
August 8, 2017: Injury
https://www.readbyqxmd.com/read/28802697/the-insertion-of-polybia-mp1-into-phospholipid-monolayers-is-regulated-by-its-anionic-nature-and-phase-state
#12
Dayane S Alvares, Natalia Wilke, João Ruggiero Neto, Maria Laura Fanani
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical properties such as membrane texture and film thickness on MP1 interaction with neutral and anionic lipid membranes. For this purpose, we first explored the peptide's surface behavior. MP1 showed high surface activity, adsorbing onto bare air/aqueous interfaces up to higher surface pressures than the collapse pressure of MP1 Langmuir films...
August 9, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28802690/nanoparticle-releasing-nanofiber-composites-for-enhanced-in%C3%A2-vivo-vaginal-retention
#13
Emily A Krogstad, Renuka Ramanathan, Christina Nhan, John C Kraft, Anna K Blakney, Shijie Cao, Rodney J Y Ho, Kim A Woodrow
Current approaches for topical vaginal administration of nanoparticles result in poor retention and extensive leakage. To overcome these challenges, we developed a nanoparticle-releasing nanofiber delivery platform and evaluated its ability to improve nanoparticle retention in a murine model. We individually tailored two components of this drug delivery system for optimal interaction with mucus, designing (1) mucoadhesive fibers for better retention in the vaginal tract, and (2) PEGylated nanoparticles that diffuse quickly through mucus...
August 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28802252/exploiting-radiation-induced-signaling-to-increase-the-susceptibility-of-resistant-cancer-cells-to-targeted-drugs-akt-and-mtor-inhibitors-as-an-example
#14
Iris Eke, Adeola Y Makinde, Molykutty J Aryankalayil, Veit Sandfort, Sanjeewani T Palayoor, Barbara H Rath, Lance Liotta, Mariaelena Pierobon, Emanuel F Petricoin, Matthew F Brown, Jayne M Stommel, Mansoor M Ahmed, C Norman Coleman
Implementing targeted drug therapy in radio-oncologic treatment regimens has greatly improved the outcome of cancer patients. However, the efficacy of molecular targeted drugs such as inhibitory antibodies or small molecule inhibitors essentially depends on target expression and activity, which both can change during the course of treatment. Radiotherapy has previously been shown to activate pro-survival pathways which can help tumor cells to adapt and thereby survive treatment. Therefore, we aimed to identify changes in signaling induced by radiation and evaluate the potential of targeting these changes with small molecules to increase the therapeutic efficacy on cancer cell survival...
August 11, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28802191/a-novel-method-for-sex-estimation-using-3d-computed-tomography-models-of-tooth-roots-a-volumetric-analysis
#15
Seyedeh M Kazzazi, Elena F Kranioti
Advances in technologies such as computed tomography (CT) scanning have allowed for further examination of dental sexual dimorphism in modern and archaeological populations.
August 4, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28802152/comparison-and-analysis-of-the-structures-and-binding-modes-of-antifungal-se-and-cyp51-inhibitors
#16
Bin Sun, Wanxu Huang, Min Liu, Kang Lei
With the abuse of clinical broad-spectrum antimicrobial agents, immunosuppressive agents, chemotherapy drugs, the emergence of pathogenic fungi resistance is more and more frequent. However, there is still no effective treatment for the fungal resistance. Squalenee epoxidase (SE) and 14 α-demethylase (CYP51) are important antifungal drug targets. In order to achieve a deeper insight into the structural characteristics and the action modes of SE and CYP51inhibitors, the homology model of SE (Candida albicans) was constructed using monooxygenase of Pseudomonas aeruginosa as template, and the reliability of model was confirmed by Ramachandran plots and Verify 3D...
August 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28802102/pnipaam-co-jeffamine-%C3%A2-pnj-scaffolds-as-in%C3%A2-vitro-models-for-niche-enrichment-of-glioblastoma-stem-like-cells
#17
John M Heffernan, James B McNamara, Sabine Borwege, Brent L Vernon, Nader Sanai, Shwetal Mehta, Rachael W Sirianni
Glioblastoma (GBM) is the most common adult primary brain tumor, and the 5-year survival rate is less than 5%. GBM malignancy is driven in part by a population of GBM stem-like cells (GSCs) that exhibit indefinite self-renewal capacity, multipotent differentiation, expression of neural stem cell markers, and resistance to conventional treatments. GSCs are enriched in specialized niche microenvironments that regulate stem phenotypes and support GSC radioresistance. Therefore, identifying GSC-niche interactions that regulate stem phenotypes may present a unique target for disrupting the maintenance and persistence of this treatment resistant population...
May 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28801918/motion-compensation-in-the-region-of-the-coronary-arteries-based-on-partial-angle-reconstructions-from-short-scan-ct-data
#18
Juliane Hahn, Herbert Bruder, Christopher Rohkohl, Thomas Allmendinger, Karl Stierstorfer, Thomas Flohr, Marc Kachelrieß
PURPOSE: In order to mitigate motion-induced artifacts, several motion compensation (MoCo) methods have been developed, which are either able to a) compensate for severe artifacts, but utilize the data for the reconstruction of several cardiac phases, or b) improve image quality of a single reconstruction with only moderate motion artifacts. We propose a method combining both benefits: dose efficiency by utilizing only the data needed for a single short-scan reconstruction while still being able to compensate for severe artifacts...
August 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28801767/experimental-validation-of-predicted-application-accuracies-for-computer-assisted-cas-intraoperative-navigation-with-paired-point-registration
#19
Martina Perwög, Zoltan Bardosi, Wolfgang Freysinger
PURPOSE: The target registration error (TRE) is a crucial parameter to estimate the potential usefulness of computer-assisted navigation intraoperatively. Both image-to-patient registration on base of rigid-body registration and TRE prediction methods are available for spatially isotropic and anisotropic data. This study presents a thorough validation of data obtained in an experimental operating room setting with CT images. METHODS: Optical tracking was used to register a plastic skull, an anatomic specimen, and a volunteer to their respective CT images...
August 11, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28801757/dft-study-of-the-interactions-between-thiophene-based-corrosion-inhibitors-and-an-fe4-cluster
#20
Duy Quang Dao, Truong Dinh Hieu, Thong Le Minh Pham, Dinh Tuan, Pham Cam Nam, Ime Bassey Obot
Understanding the physicochemical properties of corrosion inhibitors and their chemical interactions with metal surfaces is crucial to the design of improved (i.e., more efficient) corrosion inhibitors. In this work, the physicochemical properties of six thiophene-based corrosion inhibitors (2-acetylthiophene (AT), 2-formylthiophene (FT), thiophene (Th), 2-methyl-3-thiophenthiol (MTT), 2-pentylthiophene (PT), and 2-thenylthiol (TT)) were systematically studied by performing ab initio calculations at the MP2(full)/6-31G(2df,p) level of theory...
August 11, 2017: Journal of Molecular Modeling
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