keyword
https://read.qxmd.com/read/38547447/association-of-biomarkers-of-neuronal-injury-and-inflammation-with-insomnia-trajectories-after-traumatic-brain-injury-a-track-tbi-study
#1
JOURNAL ARTICLE
J Kent Werner, Jennifer Albrecht, Vincent F Capaldi, Sonia Jain, Xiaoying Sun, Pratik Mukherjee, Scott G Williams, Jacob Collen, Ramon Diaz-Arrastia, Geoffrey T Manley, Andrew D Krystal, Emerson Wickwire
BACKGROUND AND OBJECTIVES: Insomnia affects about one-third of patients with traumatic brain injury and is associated with worsened outcomes after injury. We hypothesized that higher levels of plasma neuroinflammation biomarkers at the time of TBI would be associated with worse 12-month insomnia trajectories. METHODS: Participants were prospectively enrolled from 18 level-1 trauma centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury study from February 26, 2014, to August 8, 2018...
April 23, 2024: Neurology
https://read.qxmd.com/read/38545777/the-effect-of-4-factor-prothrombin-complex-concentrate-to-reverse-factor-xa-inhibitors-in-patients-with-traumatic-intracranial-hemorrhage
#2
JOURNAL ARTICLE
Jessica L Rauh, Taron Torosian, Anothony Thompson, Meagan Evangelista, Jason Hoth
The utility of 4-factor prothrombin complex concentrate (4F-PCC) for reversal in patients on factor Xa inhibitors (XaI) is unclear, specifically in mild traumatic brain injury (mTBI). This is a retrospective review over 6 years at a level 1 trauma center of patients presenting with mTBI on XaI comparing outcomes for those that received 4F-PCC to those that did not. 140 patients were included, 103 (74%) of these patients received 4F-PCC while 37 (26%) did not. There was no significant difference in neurologic decline within 48 hours of admission or need for neurosurgical intervention...
March 28, 2024: American Surgeon
https://read.qxmd.com/read/38540256/neurotrauma-from-injury-to-repair-clinical-perspectives-cellular-mechanisms-and-promoting-regeneration-of-the-injured-brain-and-spinal-cord
#3
REVIEW
Andrew R Stevens, Antonio Belli, Zubair Ahmed
Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss of function that the central nervous system (CNS) cannot repair after the initial event is resolved. The way in which function is lost after injury is the consequence of a complex array of mechanisms that continue in the chronic phase post-injury to prevent effective neural repair...
March 13, 2024: Biomedicines
https://read.qxmd.com/read/38538745/white-and-gray-matter-integrity-evaluated-by-mri-dti-can-serve-as-noninvasive-and-reliable-indicators-of-structural-and-functional-alterations-in-chronic-neurotrauma
#4
JOURNAL ARTICLE
Lan-Wan Wang, Kuan-Hung Cho, Pi-Yu Chao, Li-Wei Kuo, Chia-Wen Chiang, Chien-Ming Chao, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin, Chung-Ching Chio
We aimed to evaluate whether white and gray matter microstructure changes observed with magnetic resonance imaging (MRI)-based diffusion tensor imaging (DTI) can be used to reflect the progression of chronic brain trauma. The MRI-DTI parameters, neuropathologic changes, and behavioral performance of adult male Wistar rats that underwent moderate (2.1 atm on day "0") or repeated mild (1.5 atm on days "0" and "2") traumatic brain injury (TBI or rmTBI) or sham operation were evaluated at 7 days, 14 days, and 1-9 months after surgery...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538271/genetic-contributions-to-recovery-following-brain-trauma-a-narrative-review
#5
REVIEW
Deepak Lakshmipathy, Shreya Rangarajan, Ariana Barreau, Jeffrey Lu, Giona Kleinberg, Brandon Lucke-Wold
Traumatic brain injury (TBI) is a frequently encountered form of injury that can have lifelong implications. Despite advances in prevention, diagnosis, monitoring, and treatment, the degree of recovery can vary widely between patients. Much of this is explained by differences in severity of impact and patient-specific comorbidities; however, even among nearly identical patients, stark disparities can arise. Researchers have looked to genetics in recent years as a means of explaining this phenomenon. It has been hypothesized that individual genetic factors can influence initial inflammatory responses, recovery mechanisms, and overall prognoses...
March 15, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38533717/examining-the-relationship-between-head-trauma-and-opioid-use-disorder-a-systematic-review
#6
JOURNAL ARTICLE
Ali Abid, Maria Paracha, Iva Çepele, Awais Paracha, Joseph Rueve, Akbar Fidahussain, Humza Rehman, McKimmon Engelhardt, Noor Alyasiry, Zohair Siddiqui, Satvik Vasireddy, Bishal Kadariya, Nikith Rao, Rohan Das, Wilson Rodriguez, Dixie Meyer
OBJECTIVE: To examine recent literature and determine common clinical risk factors between antecedent traumatic brain injury (TBI) and the following development of opioid misuse and provide a framework for clinical identification of at-risk subjects and evaluate potential treatment implications within this association. DESIGN: A comprehensive systematic literature search of PubMed was conducted for articles between 2000 and December 2022. Studies were included if the human participant had any head trauma exposure and any chronic opioid use or dependence...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533630/strongly-adhesive-self-healing-hemostatic-hydrogel-for-the-repair-of-traumatic-brain-injury
#7
JOURNAL ARTICLE
Zuoxiang Dong, Jihu Zhao, Jian Xu, Wenshuai Deng, Peng Sun
With wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons or axons after injury, as well as the inhibition of blood vessel growth by the formation of neural scars, existing treatment measures have limited effectiveness in repairing brain tissue. Herein, the biomultifunctional hydrogels are developed for TBI treatment based on the Schiff base reaction of calcium ion (Ca2+ )-cross-linked oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS)...
March 27, 2024: Biomacromolecules
https://read.qxmd.com/read/38533491/identification-of-novel-blood-based-extracellular-vesicles-biomarker-candidates-with-potential-specificity-for-traumatic-brain-injury-in-polytrauma-patients
#8
JOURNAL ARTICLE
Cora R Schindler, Jason A Hörauf, Birte Weber, Inna Schaible, Ingo Marzi, Dirk Henrich, Liudmila Leppik
OBJECTIVE: The goal of this study was to identify changes in extracellular vesicles (EV) surface proteins specific to traumatic brain injury (TBI), which could be used as a diagnostic and prognostic tool in polytrauma patients. SUMMARY BACKGROUND DATA: Known serum TBI-specific biomarkers (S100B, NSE, and GFAP), which can predict the severity and outcome of isolated TBI, lose their predictive value in the presence of additional extracranial injuries. Extracellular vesicles (EVs) are released from cells in response to various stimuli and carry specific cargo/surface molecules that could be used for tracking injury-responding cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38530411/impact-of-early-follow-up-ct-in-the-conservative-management-of-traumatic-brain-injury-on-surgical-decision-making-a-retrospective-single-center-analysis-with-special-respect-to-coagulopathy
#9
JOURNAL ARTICLE
Mats L Moskopp, Dag Moskopp, Lennart W Sannwald
INTRODUCTION: Initial management of traumatic brain injury (TBI) without immediate need for surgical therapy varies across centers. The additional value of routine repeat cranial computerized tomography (CT) to neurological monitoring is controversial. This retrospective study investigates the impact of routine follow-up CT after 6 h (CT6h) in initially conservatively managed TBI on surgical decision making. Furthermore, the impact of coagulopathy on lesion size and progression was examined...
March 26, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38529909/long-term-outcomes-of-pediatric-traumatic-brain-injury-following-inpatient-rehabilitation
#10
JOURNAL ARTICLE
Timothy C Horn, Jennifer P Lundine, Tyler A Busch, Rebekah A Benkart, H Gerry Taylor, Christine H Koterba
OBJECTIVE: Assess residual disability in youth with traumatic brain injury (TBI) treated in a pediatric inpatient rehabilitation unit and examine associations of disability with inpatient status and measures of concurrent functioning. SETTING: Large, urban, quaternary care children's hospital in the Midwestern United States. PARTICIPANTS: Forty-five youth aged 6 to 18 years treated in an inpatient rehabilitation unit for mild-complicated to severe TBI at a minimum of 12 months postdischarge (mean = 3...
March 2024: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38529908/incog-2-0-guidelines-for-cognitive-rehabilitation-following-traumatic-brain-injury-part-iii-executive-functions-erratum
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38529906/characterizing-health-literacy-and-its-correlates-among-individuals-with-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#12
JOURNAL ARTICLE
Angelle M Sander, Monique R Pappadis, Shannon B Juengst, Luis Leon-Novelo, Esther Ngan, John D Corrigan, Laura E Dreer, Simon Driver, Anthony H Lequerica
OBJECTIVE: To characterize health literacy among individuals with traumatic brain injury (TBI) at least a year postinjury and to explore its relationship to sociodemographic variables, injury severity, and cognition. SETTING: Community following discharge from inpatient rehabilitation. PARTICIPANTS: In total, 205 individuals with complicated mild to severe TBI who completed follow-up as part of a national longitudinal study of TBI and completed a web-based health literacy measure...
March 2024: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38529441/prehospital-cervical-spine-c-spine-stabilization-and-airway-management-in-a-trauma-patient-a-review
#13
REVIEW
Utkarsh M Waghmare, Akhilesh Singh
Severe traumatic damage to the brain-to-body signaling bundle that results in bruising and a partial or total tear of the spinal cord is known as a spinal cord injury (SCI). SCI may develop at the time of an event or after. It can also develop while handling the patient and can worsen during the transportation of the patient. So prehospital care is crucial to prevent or minimize SCI. Prehospital care involves examining the patient, immobilizing the cervical spine (C-spine), providing cardiovascular support (keeping the mean arterial blood pressure over 85 mmHg), and carefully managing the airway (possibly intubating the patient using manual in-line stabilization (MILS))...
February 2024: Curēus
https://read.qxmd.com/read/38528477/frequency-and-predictors-of-headache-in-the-first-12-months-after-traumatic-brain-injury-results-from-center-tbi
#14
JOURNAL ARTICLE
Emilie Isager Howe, Nada Andelic, Cathrine Brunborg, Marina Zeldovich, Eirik Helseth, Toril Skandsen, Alexander Olsen, Silje C R Fure, Alice Theadom, Katrin Rauen, Benedikte Å Madsen, Bram Jacobs, Joukje van der Naalt, Maria Carmela Tartaglia, Cathrine Elisabeth Einarsen, Gøril Storvig, Erling Tronvik, Cathrine Tverdal, Nicole von Steinbüchel, Cecilie Røe, Torgeir Hellstrøm
BACKGROUND: Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury...
March 25, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38525740/risk-factors-analysis-for-90-day-mortality-of-adult-patients-with-mild-traumatic-brain-injury-in-an-italian-emergency-department
#15
JOURNAL ARTICLE
Daniele Orso, Giulia Furlanis, Alice Romanelli, Federica Gheller, Marzia Tecchiolli, Franco Cominotto
Purpose : The most prominent risk factors for mortality after mild traumatic brain injury (TBI) have not been established. This study aimed to establish risk factors related to 90-day mortality after a traumatic event. Methods : A retrospective cohort study on adult patients entering the Emergency Department of the University Hospital of Trieste for mild TBI from 1 January 2020 to 31 December 2020 was conducted. Results : The final population was 1221 patients (median age of 78 years). The 90-day mortality rate was 7% (90 patients)...
February 23, 2024: Geriatrics
https://read.qxmd.com/read/38523124/reducing-low-value-interhospital-transfers-for-mild-traumatic-brain-injury
#16
JOURNAL ARTICLE
Aricia Shen, Nathaniel Mizraki, Marcel Maya, Sam Torbati, Shouri Lahiri, Ray Chu, Daniel Margulies, Galinos Barmparas
BACKGROUND: The modified Brain Injury Guidelines (mBIG) were developed to stratify traumatic brain injuries (TBI) and improve healthcare utilization by selectively requiring repeat imaging, ICU admission, and neurosurgical (NSG) consultation. The goal of this study is to assess safety and potential resource savings associated with the application of mBIG on interhospital patient transfers for TBI. METHODS: Adult patients with TBI transferred to our Level I trauma center from 01/2017 to 12/2022 meeting mBIG inclusion criteria were retrospectively stratified into mBIG1, mBIG2, and mBIG3 based on initial clinicoradiological factors...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38523120/the-sensitivity-of-limited-sequence-mri-in-identifying-pediatric-cervical-spine-injury-a-western-pediatric-surgery-research-consortium-multicenter-retrospective-cohort-study
#17
JOURNAL ARTICLE
Caroline Melhado, Rachelle Durand, Katie W Russell, Natalya E Polukoff, John Rampton, Rajiv R Iyer, Shannon N Acker, Richele Koehler, Connor Prendergast, Nicholas Stence, Brent O'Neill, Benjamin E Padilla, Ramin Jamshidi, Jennifer A Vaughn, Jennifer S Ronecker, Leigh Selesner, Katrine Lofberg, Michael Regner, Jaclyn Thiessen, Christine Sayama, Ryan G Spurrier, Erin E Ross, Chia-Shang Jason Liu, Jason Chu, Kathryn McNevin, Catherine Beni, Bryce R H Robinson, Ken Linnau, Robert T Buckley, Stephanie D Chao, Akanksha Sabapaty, Elizabeth Tong, Laura M Prolo, Romeo Ignacio, Gretchen Floan Sachs, Peter Kruk, David Gonda, Mark Ryan, Samir Pandya, Korgun Koral, Bruno P Braga, Kurtis Auguste, Aaron R Jensen
INTRODUCTION: Clinical clearance of a child's cervical spine after trauma is often challenging due to impaired mental status or an unreliable neurologic examination. Magnetic resonance imaging (MRI) is the gold standard for excluding ligamentous injury in children but is constrained by long image acquisition times and frequent need for anesthesia. Limited-sequence MRI (LSMRI) is used in evaluating the evolution of traumatic brain injury and may also be useful for cervical spine clearance while potentially avoiding the need for anesthesia...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38519935/partial-facial-paralysis-induced-by-sialolithiasis-of-the-parotid-gland-a-case-report
#18
JOURNAL ARTICLE
Abhinav Suri, Stephen Avila, Christina Tan, Huda Alalami, Jennifer Harris
BACKGROUND: Facial paralysis due to parotid sialolithiasis-induced parotitis is a unusual clinical phenomenon that has not been reported in prior literature. This scenario can present a diagnostic challenge due to its rarity and complex symptomatology, particularly if a patient has other potential contributing factors such as facial trauma or bilateral forehead botox injections as in this patient. This case report elucidates such a complex presentation, aiming to increase awareness and promote timely recognition among clinicians...
March 22, 2024: BMC Neurology
https://read.qxmd.com/read/38518270/psychedelic-therapy-a-primer-for-primary-care-clinicians-ibogaine
#19
JOURNAL ARTICLE
Kirsten Cherian, Kenneth Shinozuka, Burton J Tabaac, Alejandro Arenas, Bryce D Beutler, Viviana D Evans, Chelsey Fasano, Owen S Muir
BACKGROUND: Ibogaine is a plant-derived alkaloid that has been used for thousands of years in rites of passage and spiritual ceremonies in West-Central Africa. In the West, it has primarily been used and studied for its anti-addictive properties and more recently for other neuropsychiatric indications, including post-traumatic stress disorder, depression, anxiety, and traumatic brain injury. AREAS OF UNCERTAINTY: Ibogaine requires careful patient screening and monitoring because of significant safety issues...
March 2024: American Journal of Therapeutics
https://read.qxmd.com/read/38517382/pathophysiology-of-severe-burn-injuries-new-therapeutic-opportunities-from-a-systems-perspective
#20
JOURNAL ARTICLE
Geoffrey P Dobson, Jodie L Morris, Hayley L Letson
Severe burn injury elicits a profound stress response with the potential for high morbidity and mortality. If polytrauma is present, patient outcomes appear to be worse. Sex-based comparisons indicate females have worse outcomes than males. There are few effective drug therapies to treat burn shock and secondary injury progression. The lack of effective drugs appears to arise from the current treat-as-you-go approach rather than a more integrated systems approach. In this review, we present a brief history of burns research and discuss its pathophysiology from a systems' perspective...
March 22, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
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