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Trauma brain injury

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https://www.readbyqxmd.com/read/28936067/external-validation-of-the-rotterdam-computed-tomography-score-in-the-prediction-of-mortality-in-severe-traumatic-brain-injury
#1
Jose D Charry, Jesus D Falla, Juan D Ochoa, Miguel A Pinzón, Jorman H Tejada, Maria J Henriquez, Juan Pablo Solano, Camilo Calvache
INTRODUCTION: Traumatic brain injury (TBI) is a public health problem. It is a pathology that causes significant mortality and disability in Colombia. Different calculators and prognostic models have been developed to predict the neurological outcomes of these patients. The Rotterdam computed tomography (CT) score was developed for prognostic purposes in TBI. We aimed to examine the accuracy of the prognostic discrimination and prediction of mortality of the Rotterdam CT score in a cohort of trauma patients with severe TBI in a university hospital in Colombia...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935892/bioenergetic-state-regulates-innate-inflammatory-responses-through-the-transcriptional-co-repressor-ctbp
#2
Yiguo Shen, David Kapfhamer, Angela M Minnella, Ji-Eun Kim, Seok Joon Won, Yanting Chen, Yong Huang, Ley Hian Low, Stephen M Massa, Raymond A Swanson
The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflammatory response, but how this occurs is unclear. Here, we show that glucose metabolism regulates pro-inflammatory NF-κB transcriptional activity through effects on the cytosolic NADH:NAD(+) ratio and the NAD(H) sensitive transcriptional co-repressor CtBP. Reduced glucose availability reduces the NADH:NAD(+) ratio, NF-κB transcriptional activity, and pro-inflammatory gene expression in macrophages and microglia...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28933223/genetic-and-histological-alterations-reveal-key-role-of-prostaglandin-synthase-and-cyclooxygenase-1-and-2-in-traumatic-brain-injury-induced-neuroinflammation-in-the-cerebral-cortex-of-rats-exposed-to-moderate-fluid-percussion-injury
#3
Hideki Shojo, Cesario V Borlongan, Tadashi Mabuchi
After the initial insult in traumatic brain injury (TBI), secondary neurodegeneration occurs that is intimately associated with neuroinflammation. Prostaglandin (PG) synthases and cyclooxygenase (COX) 1 and 2 may contribute to inflammation in the brain. Temporal and spatial expression features of PG and COX1 and 2 following trauma may guide the development of antineuroinflammation strategies. Here, we examined PG synthase signaling and COX1 and 2 gene expression levels and COX-1- and 2-positive cell types and their temporal localization in TBI-induced brain in an effort to reveal their participation in the disease's evolving neuroinflammation...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28933212/impact-of-traumatic-brain-injury-on-dopaminergic-transmission
#4
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Jonathan Miller, Yung-Hsiao Chiang, Barry J Hoffer
Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI)...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28931486/caring-for-the-veteran-military-and-family-member-nursing-competencies-strategies-for-integrating-content-into-nursing-school-curricula
#5
Libba Reed McMillan, David Crumbley, Julie Freeman, Marilyn Rhodes, Michele Kane, Joy Napper
In the United States, one in every 15 persons is a Veteran (U. S. Department of Veterans Affairs, 2016; U. S. News & World Report, 2017). An estimated 27% of these Veterans receive healthcare through the Veteran's Health Administration (VHA), leaving 73% to seek care in civilian hospitals (Bagalman, 2014). Realistically, most nurses in the United States will care for military members, Veterans or family members in a variety of healthcare systems and settings. Nurse educators are positioned to lead efforts in providing nursing students with the knowledge necessary to provide competent care and serve as advocates for our nation's heroes...
September 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28931364/plasminogen-activator-inhibitor-type-1-a-possible-novel-biomarker-of-late-pituitary-dysfunction-after-mild-traumatic-brain-injury
#6
Istvan Frendl, Monika Katko, Erika Galgoczi, Judit Boda, Noemi Zsiros, Zoltan Nemeti, Zsuzsanna Bereczky, Renata Hudak, Janos Kappelmayer, Annamaria Erdei, Bela Turchanyi, Endre V Nagy
More than 80% of head trauma patients suffer from mild traumatic brain injury (mTBI). However, even mTBI carries the risk of late pituitary dysfunction. A predictive biomarker at the time of injury which could identify patients who subsequently may develop permanent pituitary dysfunction would help to direct patients towards endocrine care. We enrolled 508 traumatic brain injury patients (406 with mTBI) into our study. Blood samples were collected for identification of predictive biomarkers of late pituitary dysfunction at the time of admission...
September 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28931334/repeated-exposure-to-experimental-pain-differentiates-combat-tbi-with-and-without-ptsd
#7
Irina A Strigo, Andrea D Spadoni, Sabra S Inslicht, Alan N Simmons
Mild traumatic brain injury(mTBI) and posttraumatic stress disorder(PTSD) are highly comorbid conditions that often co-occur with chronic pain. We have shown that women with PTSD following intimate partner violence show attenuated brain response to repeated experimental pain that was related to symptoms of avoidance. The aim of this study was to extend our prior findings to males with combat trauma and to examine brain response to experimental pain in men with and without PTSD who sustained mTBI during combat...
September 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28930945/effects-of-propranolol-and-clonidine-on-brain-edema-blood-brain-barrier-permeability-and-endothelial-glycocalyx-disruption-following-fluid-percussion-brain-injury-in-the-rat
#8
Gustav Folmer Genét, Peter Bentzer, Morten Bagge Hansen, Sisse Rye Ostrowski, Pär Ingemar Johansson
BACKGROUND: Traumatic brain injury causes a disruption of the vascular endothelial glycocalyx layer that is associated with an overactivation of the sympathoadrenal system. We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain-barrier permeability and glycocalyx disruption at 24 hours after trauma. METHODS: We subjected fifty-three adult male Sprague-Dawley rats to lateral fluid-percussion brain injury and randomized infusion with propranolol (n=16), propranolol+clonidine (n=16), vehicle (n=16) or sham (n=5) for 24 hours...
September 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930046/canadian-benchmarks-for-acute-injury-care
#9
Lynne Moore, David Evans, Natalie L Yanchar, Jaimini Thakore, Henry Thomas Stelfox, Sayed Morad Hameed, Richard Simons, John Kortbeek, Julien Clément, François Lauzier, Alexis F Turgeon
BACKGROUND: Acute care injury outcomes vary substantially across Canadian provinces and trauma centres. Our aim was to develop Canadian benchmarks to monitor mortality and hospital length of stay (LOS) for injury admissions. METHODS: Benchmarks were derived using data from the Canadian National Trauma Registry on patients with major trauma admitted to any level I or II trauma centre in Canada and from the following patient subgroups: isolated traumatic brain injury (TBI), isolated thoracoabdominal injury, multisystem blunt injury, age 65 years or older...
October 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28928193/the-course-and-prognostic-factors-of-cognitive-status-after-central-nervous-system-trauma-a-systematic-review-protocol
#10
Tatyana Mollayeva, Nicole Pacheco, Andrea D'Souza, Angela Colantonio
INTRODUCTION: Traumatic brain injury (TBI) is among the most disabling injuries, resulting in a range of cognitive impairments. Traumatic spinal cord injury (SCI) often occurs in conjunction with TBI; the two are best considered together in the context of trauma to the central nervous system (CNS). Despite strong indications of cognitive dysfunction in CNS trauma, little is known about its natural history or relationship with other factors. The current protocol outlines a strategy for a systematic review of the current evidence examining CNS trauma as a prognostic factor of cognitive decline in the adult population...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28926484/alcohol-and-drug-use-before-and-during-the-first-year-after-traumatic-brain-injury
#11
Simon Beaulieu-Bonneau, Frédéric St-Onge, Marie-Claude Blackburn, Andrée Banville, Andrée-Anne Paradis-Giroux, Marie-Christine Ouellet
OBJECTIVES: To compare individuals with mild and moderate/severe traumatic brain injury (TBI) on alcohol and drug use and substance use disorders before and in the first year post-TBI; to explore sociodemographic and injury-related variables associated with substance use disorders. PARTICIPANTS: A total of 225 adults hospitalized in a level I trauma center after TBI. DESIGN: Observational cohort study with retrospective (pre-TBI) and prospective (4, 8, and 12 months post-TBI) assessments...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28926480/postconcussive-symptoms-over-the-first-14-days-after-mild-traumatic-brain-injury-an-experience-sampling-study
#12
Maria Pacella, Arjun Prabhu, Julia Morley, Stephanie Huang, Brian Suffoletto
OBJECTIVE: This study examined changes in postconcussive symptoms (PCS) over the acute postinjury recovery period, focusing on how daily PCSs differ between mild traumatic brain injury (mTBI) and other injury types. SETTING: An urban emergency department (ED) in Western Pennsylvania. SUBJECTS: A total of 108 adult patients with trauma being discharged from the ED were recruited and grouped by injury type: mild TBI (mTBI; n = 39), head injury without mTBI (HI: n = 16), and non-head-injured trauma controls (TCs: n = 53)...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28923560/computed-tomography-findings-in-young-children-with-minor-head-injury-presenting-to-the-emergency-department-greater-than-24h-post-injury
#13
Renana Gelernter, Giora Weiser, Eran Kozer
BACKGROUND: Large studies which developed decision rules for the use of Computed tomography (CT) in children with minor head trauma excluded children with late presentation (more than 24h). OBJECTIVE: To assess the prevalence of significant traumatic brain injury (TBI) on CT in infants with head trauma presenting to the emergency department (ED) more than 24h from the injury. METHODS: A retrospective chart review of infants less than 24 months old referred for head CT because of traumatic brain injury from January 2004 to December 2014 in Assaf-Harofeh medical center was conducted...
September 11, 2017: Injury
https://www.readbyqxmd.com/read/28922710/paediatric-mild-head-injury-is-routine-admission-to-a-tertiary-trauma-hospital-necessary
#14
Krishna Tallapragada, Ratna Soundarya Peddada, Mark Dexter
BACKGROUND: Previous studies have shown that children with isolated linear skull fractures have excellent clinical outcomes and low risk of surgery. We wish to identify other injury patterns within the spectrum of paediatric mild head injury, which need only conservative management. Children with low risk of evolving neurosurgical lesions could be safely managed in primary hospitals. METHODS: We retrospectively analysed all children with mild head injury (i.e. admission Glasgow coma score 13-15) and skull fracture or haematoma on a head computed tomography scan admitted to Westmead Children's Hospital, Sydney over the years 2009-2014...
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28921171/high-fibrin-fibrinogen-degradation-product-to-fibrinogen-ratio-is-associated-with-28-day-mortality-and-massive-transfusion-in-severe-trauma
#15
D H Lee, B K Lee, S M Noh, Y S Cho
PURPOSE: There is a lack of association between coagulation biomarkers and long-term mortality in severe trauma. We aimed to investigate the association between coagulation biomarkers on admission and outcome of late stage of trauma. METHODS: This retrospective observational study included patients admitted with severe trauma between 2012 and 2015. We used the area under the receiver operating characteristic curve (AUROC) of coagulation biomarkers to determine 28-day mortality...
September 18, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28919762/risk-of-post-traumatic-epilepsy-after-severe-head-injury-in-patients-with-at-least-one-seizure
#16
Wei Chen, Ming-De Li, Gui-Fang Wang, Xia-Feng Yang, Lin Liu, Fan-Gang Meng
BACKGROUND: To explore the incidence and risk factors, including type of seizures for post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI). SUBJECTS AND METHODS: This was a retrospective follow-up study of patients discharged from Liaocheng People's Hospital between March 2011 and June 2015 with a diagnosis of post-traumatic seizures. Risk factors for PTE were evaluated in 68 inpatients by using Kaplan-Meier curves and the Cox model. RESULTS: Complete clinical information was available for 68 patients...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28918531/penetrating-orbital-trauma-leading-to-trans-orbital-brain-herniation
#17
Siddharth Vankipuram, Chittij Srivastava, B K Ojha, Sushant Sahoo
INTRODUCTION: Development of a posttraumatic herniation of brain parenchyma through the orbit is a rare complication of orbital roof fracture. Mostly, the injury is due to a direct impact to the frontal region resulting in orbital roof fracture with dural defect and herniation of cerebrospinal fluid or brain parenchyma. These patients present with acute or gradually progressive proptosis with impending risk of loss of vision and mandate surgical decompression of optic nerve with watertight closure of the dural defect...
September 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28917584/pneumatoceles-in-pediatric-blunt-trauma-common-and-benign
#18
Lindsey B Armstrong, David P Mooney
INTRODUCTION: Traumatic pneumatoceles are reported to be rare in children and to have an uncertain clinical significance. We report a single institution series of traumatic pneumatoceles to better define their frequency and clinical significance. METHODS: After obtaining approval from the IRB, data were extracted from the trauma registry of a level 1 pediatric trauma center on children diagnosed with a pulmonary contusion (International Classification of Diseases-9th edition diagnosis codes: 861...
August 7, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28916852/pediatric-head-trauma-an-extensive-review-on-imaging-requisites-and-unique-imaging-findings
#19
REVIEW
F C Sarioglu, H Sahin, Y Pekcevik, O Sarioglu, O Oztekin
The effects of trauma in children are different due to association with some anatomical and physiological differences compared with adults. The role of neuroimaging gains importance in early detection of traumatic brain injuries and prevention of secondary post-traumatic complications. Many algorithms are described for children with head trauma to decide the necessity of a computed tomography scan. The aims of this article are to describe differences of these algorithms, the mechanism of traumatic brain injury with radiological imaging findings in the pediatric population, and explain complications of undiagnosed traumatic brain lesions...
September 15, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28913711/emergency-neurological-life-support-resuscitation-following-cardiac-arrest
#20
Jonathan Elmer, Kees H Polderman
Cardiac arrest is the most common cause of death in North America. An organized bundle of neurocritical care interventions can improve chances of survival and neurological recovery in patients who are successfully resuscitated from cardiac arrest. Therefore, resuscitation following cardiac arrest was chosen as an Emergency Neurological Life Support protocol. Key aspects of successful early post-arrest management include: prevention of secondary brain injury; identification of treatable causes of arrest in need of emergent intervention; and, delayed neurological prognostication...
September 14, 2017: Neurocritical Care
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