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helicobacter pylori eradication

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https://www.readbyqxmd.com/read/28315035/primary-antibiotic-resistance-of-helicobacter-pylori-in-china
#1
REVIEW
Yi Hu, Yin Zhu, Nong-Hua Lu
BACKGROUND AND AIMS: Antibiotic resistance is the most important factor leading to the failure of eradication regimens; thus, it is important to obtain regional antibiotic resistance information. This review focuses on the prevalence of Helicobacter pylori primary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and furazolidone in China. METHODS: We searched the PubMed, EMBASE, the China National Knowledge Infrastructure, and Chinese Biomedical databases from the earliest date of each database to October 2016...
March 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28303625/eradication-rate-of-helicobacter-pylori-infection-is-directly-influenced-by-adherence-to-therapy-in-children
#2
Kallirroi Kotilea, Joyce Mekhael, Assaad Salame, Tania Mahler, Veronique Yvette Miendje-Deyi, Samy Cadranel, Patrick Bontems
BACKGROUND: Current commonly accepted strategies to eradicate Helicobacter pylori in children are a 10-day sequential treatment or a triple therapy for 7-14 days. To avoid further expensive and possibly risky investigations as well as induction of secondary antimicrobial resistance, a success rate of elimination strategies over 90% in a per-protocol analysis is the target goal but rates observed in clinical trials are lower. Antimicrobial resistance is a well-recognized risk factor for treatment failure; therefore, only a treatment tailored to susceptibility testing should be recommended...
March 17, 2017: Helicobacter
https://www.readbyqxmd.com/read/28301676/deprescribing-versus-continuation-of-chronic-proton-pump-inhibitor-use-in-adults
#3
REVIEW
Taline A Boghossian, Farah Joy Rashid, Wade Thompson, Vivian Welch, Paul Moayyedi, Carlos Rojas-Fernandez, Kevin Pottie, Barbara Farrell
BACKGROUND: Proton pump inhibitors (PPIs) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (GERD), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory conditions (e.g. Zollinger-Ellison syndrome), and as part of the eradication therapy for Helicobacter pylori bacteria. However, approximately 25% to 70% of people are prescribed a PPI inappropriately. Chronic PPI use without reassessment contributes to polypharmacy and puts people at risk of experiencing drug interactions and adverse events (e...
March 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28294543/probiotics-as-an-adjuvant-treatment-in-helicobacter-pylori-eradication-therapy
#4
REVIEW
Xinyan Zhu, Fei Liu
Over 80% population with Helicobacter pylori (H. pylori) infection is asymptomatic. H. pylori was considered as a primary reason for various natural gastric physiopathology. Increased antibiotic resistance and less medication compliance lead to the failure of antibiotic eradication therapy. Probiotics have been applied as a supplementary treatment in H. pylori eradication therapy in recent years. They have direct and indirect inhibitory effects on H. pylori in both animal models and clinical trials. Because of the improvement in eradication rates and therapy-related side effects, probiotics have been considered as the useful supplementation to current eradication therapy although the treatment outcomes were controversial due to the heterogeneity of probiotics in species, strains, doses and therapeutic duration...
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28294071/safety-of-one-week-first-line-standard-triple-therapy-for-helicobacter-pylori-eradication-in-a-japanese-population
#5
Kazutoshi Hori, Tetsuya Takagawa, Nobuyuki Hida, Shiro Nakamura
BACKGROUND: Standard triple therapy with the proton pump inhibitors, clarithromycin and amoxicillin for Helicobacter pylori infection is considered to be safe; however, the development of significant adverse events (AEs), such as skin rashes, has been reported. OBJECTIVE: To reconfirm the safety of this treatment. METHODS: This was a retrospective cohort study. After the exclusion of patients allergic to penicillin, 322 consecutive patients, consisting of 305 outpatients and 17 inpatients, had received the first-line eradication treatment with lansoprazole (30 mg), clarithromycin (200 mg), and amoxicillin (750 mg) twice daily for 7 days...
March 9, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28288705/clinical-aspects-and-therapy-of-gastrointestinal-malt-lymphoma
#6
REVIEW
Catherine Thieblemont, Emanuele Zucca
Extranodal marginal zone B-cell lymphomas of the mucosa associated lymphoid tissue (MALT) arise from lymphoid populations that are induced by chronic inflammation in extranodal sites. Among the MALT lymphomas, gastrointestinal (GIT) MALT lymphoma is the most frequent compared to non-GIT MALT lymphoma arising from other sites. Gastric MALT lymphoma has been the first to be described with the evidence of an etiopathogenetic link provided by the association between Helicobacter pylori-positive gastritis and gastric MALT lymphoma...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28288471/early-stage-gastric-cancer-can-be-found-in-improved-atrophic-mucosa-over-time-from-successful-helicobacter-pylori-eradication
#7
Atsushi Majima, Osamu Handa, Yuji Naito, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yoshito Itoh
BACKGROUND/AIMS: Early-stage gastric cancer (EGC) is detected even after successful Helicobacter pylori eradication. This study is aimed at clarifying the clinicopathological characteristics of EGC detected after successful H. pylori eradication. METHODS: This retrospective study analyzed 57 cases of EGC detected after successful H. pylori eradication and resected endoscopically at Kyoto Prefectural University of Medicine, between January 2009 and June 2014. Clinicopathological findings of 57 cases (H...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28275685/the-clinical-evidence-linking-helicobacter-pylori-to-gastric-cancer
#8
REVIEW
Steven F Moss
Gastric cancer has long been recognized to be accompanied and preceded by chronic gastritis, lasting decades. Arguably, the most important development in our understanding of gastric cancer pathogenesis over the past 50 years has been the realization that, for most cases of gastric cancer, Helicobacter pylori is the cause of the underlying gastritis. Gastritis can promote gastric carcinogenesis, typically via the Correa cascade of atrophic gastritis, intestinal metaplasia, and dysplasia. Nested case-control studies have shown that H pylori infection increases the risk of gastric cancer significantly, both of the intestinal and diffuse subtypes, and that H pylori is responsible for approximately 90% of the world's burden of noncardia gastric cancer...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28272373/%C3%AE-defensins-in-the-fight-against-helicobacter-pylori
#9
REVIEW
Raffaela Pero, Lorena Coretti, Ersilia Nigro, Francesca Lembo, Sonia Laneri, Barbara Lombardo, Aurora Daniele, Olga Scudiero
Antimicrobial peptides (AMPs) play a pivotal role in the innate immune responses to Helicobacter pylori (Hp) in humans. β-Defensins, a class of cationic arginine-rich AMPs, are small peptides secreted by immune cells and epithelial cells that exert antimicrobial activity against a broad spectrum of microorganisms, including Gram-positive and Gram-negative bacteria and fungi. During Hp infections, AMP expression is able to eradicate the bacteria, thereby preventing Hp infections in gastrointestinal tract. It is likely that gastric β-defensins expression is increased during Hp infection...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28267193/nya-riktlinjer-f%C3%A3-r-handl%C3%A3-ggning-av-dyspepsi-h-pylori-och-mags%C3%A3-r
#10
Lars Agreus, Magnus Simrén
New Swedish guidelines for the management of dyspepsia, H pylori, and duodenal and gastric ulcers The management of dyspepsia in Sweden differs between national county councils, and is often not in line with international recommendations. The Swedish Society of Gastroenterology has together with the Swedish College of General Practice (SFAM) developed new national guidelines for the management of uninvestigated dyspepsia, functional dyspepsia, Helicobacter pylori, and uncomplicated duodenal and gastric ulcers...
February 28, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28266875/ten-days-of-levofloxacin-containing-concomitant-therapy-can-achieve-effective-helicobacter-pylori-eradication-in-patients-with-type-2-diabetes
#11
Yao-Jong Yang, Chung-Tai Wu, Horng-Yih Ou, Chin-Han Lin, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hsiao-Bai Yang, Cheng-Chan Lu, Bor-Shyang Sheu
BACKGROUND: This study investigated whether levofloxacin-containing concomitant therapy can effectively eradicate Helicobacter pylori infection in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 797 T2DM patients were screened for anti-H. pylori IgG antibodies, and the presence of H. pylori infection was confirmed by (13)C-urea breath test. We prospectively randomized 114 of these patients to receive either 10 d of levofloxacin-concomitant therapy (n = 55) or sequential therapy (n = 59)...
March 7, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28265894/endoscopic-ultrasonography-features-of-gastric-mucosal-cobblestone-like-changes-from-a-proton-pump-inhibitor
#12
Shuichi Miyamoto, Takahiko Kudo, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Yuichi Shimizu, Naoya Sakamoto
A 68-year-old man with no symptoms presented to Hokkaido University Hospital for esophagogastroduodenoscopy screening. He had a history of Helicobacter pylori eradication. Initial esophagogastroduodenoscopy showed no gastric cobblestone-like mucosa or gastric cracked mucosa. After 1 year, he received esomeprazole (20 mg) once daily for heartburn at another hospital. Esophagogastroduodenoscopy was performed after 2 years of esomeprazole administration. Endoscopic findings showed that after H. pylori eradication, according to the Kyoto classification, gastric cobblestone-like mucosa presented in the gastric body area...
March 6, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28263101/advances-in-diagnosis-and-treatment-of-helicobacter-pylori-infection
#13
Reza Ranjbar, Payam Behzadi, Shohreh Farshad
Helicobacter pylori is a Gram-negative motile bacterium causative agent of acute and chronic digestive and extra-digestive human infections. According to different reports worldwide, H. pylori symptomatic and asymptomatic infections are a global problem. The statistical investigations show a percentage of 50 for people who are involved in H. pylori acute/chronic digestive and/or extra-digestive infections around the world. This review focuses on digestive and extra-digestive diseases caused by H. pylori, the related virulence factors, diagnostic techniques including non-invasive and invasive diagnostics and treatment...
March 6, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28260914/helicobacter-pylori-infection-is-not-associated-with-failure-to-thrive-a-case-control-study
#14
Nan-Chang Chiu, Chien-Yu Lin, Hsin Chi, Chun-Yan Yeung, Wei-Hsin Ting, Wai-Tao Chan, Chuen-Bin Jiang, Sung-Tse Li, Chao-Hsu Lin, Hung-Chang Lee
PURPOSE: The long-term impact of Helicobacter pylori infection is complex, and concerns about the need for eradication exist. We conducted this case control study to investigate the association between H. pylori infection and failure to thrive (FTT). PATIENTS AND METHODS: From January 2009 to December 2011, 53 children with FTT group and matched children with the same sex and age and similar socioeconomic status without FTT (control group) were enrolled. A questionnaire was administered to the parents/guardian, and a (13)C-urea breath test was performed to detect H...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28260713/a-case-of-gastric-type-adenoma-with-chief-cell-and-parietal-cell-differentiation-surrounded-by-complete-intestinal-metaplasia
#15
Ryutaro Furukawa, Tsuneo Oyama, Akiko Takahashi, Nobukazu Yorimitsu, Tadakazu Shimoda, Hiroyoshi Ota, Satoshi Shiozawa
A man in his 70s received Helicobacter pylori eradication therapy after endoscopic submucosal dissection (ESD) of the stomach. A small, yellowish, protuberant lesion was later observed on the anterior wall of the lower body of the stomach on surveillance esophagogastroduodenoscopy. Narrow band imaging-magnified endoscopy showed an irregular pit and net-like vascular pattern, with the background mucosa having a light blue crest pattern. A biopsy was performed, which led to a diagnosis of adenoma with a gastric phenotype, so repeat ESD was performed...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28246480/second-line-bismuth-containing-quadruple-therapy-for-helicobacter-pylori-eradication-and-impact-of-diabetes
#16
Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Hae Koo Kim, Young Dal Lee
AIM: To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure. METHODS: This study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28244264/real-world-practice-and-expectation-of-asia-pacific-physicians-and-patients-in-helicobacter-pylori-eradication-reap-hp-survey
#17
Yoen-Young Chuah, Deng-Chyang Wu, Seng-Kee Chuah, Jyh-Chin Yang, Tzong-Hsi Lee, Hong-Zen Yeh, Chan-Lin Chen, Yu-Hwa Liu, Ping-I Hsu
OBJECTIVE: The aims of the study were: 1, to survey the most popular anti-H. pylori regimens in Asia-Pacific region and the real-world effectiveness of these regimens; and 2, to investigate the expectation gaps of eradication rate between physicians and patients. DESIGN: A questionnaire was distributed to Asia-Pacific physicians who attended the Asia-Pacific Digestive Week 2015 meeting. Reported eradication rates from the literatures were compared with real-world rates of surveyed popular regimens within the region...
February 28, 2017: Helicobacter
https://www.readbyqxmd.com/read/28242673/bifunctional-enzyme-spot-is-involved-in-the-clarithromycin-tolerance-of-helicobacter-pylori-by-up-regulating-the-transporters-hp0939-hp1017-hp0497-and-hp0471
#18
Xiwen Geng, Wen Li, Zhenghong Chen, Sizhe Gao, Wei Hong, Xiaoran Ge, Guihua Hou, Zhekai Hu, Yabin Zhou, Beini Zeng, Wenjuan Li, Jihui Jia, Yundong Sun
Clarithromycin (CLA) is a commonly recommended drug for Helicobacter pylori eradication. However, the prevalence of CLA-resistant H. pylori is increasing. Although point mutations in the 23S ribosomal RNA (rRNA) are key factors for CLA resistance, other factors, including efflux pumps and regulation genes, are also involved in the CLA resistance of H. pylori Guanosine 3' -diphosphate 5' -triphosphate and guanosine 3', 5' -bispyrophosphate ((p)ppGpp), which are synthesized by the bifunctional enzyme SpoT in H...
February 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28239079/rifabutin-based-fourth-and-fifth-line-rescue-therapy-in-patients-with-for-helicobacter-pylori-eradication-failure
#19
Jihee Sung, Nayoung Kim, Yo Han Park, Young Jae Hwang, Soohoon Kwon, Gyeongjae Na, Joon Young Choi, Jae Bin Kang, Hye Rang Kim, Jin Wook Kim, Dong Ho Lee
Background/Aims: Optimized regimen has not yet been established for failures of multiple Helicobacter pylori (H. pylori) eradication. Hence, we aimed to evaluate the efficacy of rifabutin-based rescue therapy, at least after three eradication failures. Methods: Twelve patients, who failed in the treatment for H. pylori eradication at least three times, were consecutively enrolled between 2007 and 2015 at Seoul National University Bundang Hospital. The rifabutin-based rescue regimen was consisted of proton pump inhibitor (PPI), rifabutin (150 mg b...
February 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28229552/h-pylori-as-a-predictor-of-marginal-ulceration-a-nationwide-analysis
#20
Allison R Schulman, Marwan S Abougergi, Christopher C Thompson
OBJECTIVE: Helicobacter pylori has been implicated as a risk factor for development of marginal ulceration following gastric bypass, although studies have been small and yielded conflicting results. This study sought to determine the relationship between H. pylori infection and development of marginal ulceration following bariatric surgery in a nationwide analysis. METHODS: This was a retrospective cohort study using the 2012 Nationwide Inpatient Sample (NIS) database...
March 2017: Obesity
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