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https://www.readbyqxmd.com/read/28034439/you-can-t-blame-the-wreck-on-the-train
#1
John R Potts
General surgical residency education is faced with a number of challenges today. Among those are resident duty hour limitations, the fact that residency is hospital-based despite the practice of general surgery being largely outpatient, changing diseases and conditions treated by the general surgeon and changing methods of treatment, development and maintenance of a user friendly curriculum and the support and provision for faculty development. The greatest single barrier, though, to education of the surgical resident is the lack of appropriate supervision...
December 21, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28011759/-end-stage-heart-failure-therapy-potential-lessons-from-congenital-heart-disease-from-pulmonary-artery-banding-and-interatrial-communication-to-parallel-circulation
#2
REVIEW
Dietmar Schranz, Hakan Akintuerk, Norbert F Voelkel
The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Based on pathophysiological insights regarding (1) the long-term impact of an obstructive pulmonary outflow tract in neonates with congenitally corrected transposition of the great arteries, (2) the importance of a restrictive versus a non-restrictive atrial septum in neonates born with a borderline left ventricle and (3) the significance of both, a patent foramen ovale and/or open ductus arteriosus for survival of newborns with persistent pulmonary hypertension, the current review introduces some therapeutical strategies that may be applicable to selected patients with heart failure...
December 23, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27995624/diagnosing-liver-fibrosis-a-narrative-review-of-current-literature-for-dermatologists
#3
REVIEW
J R Potts, C M Maybury, A Salam, J N Barker, K Agarwal, C H Smith
Chronic liver disease is a growing problem worldwide due to obesity, alcohol-related liver disease and viral hepatitis. Liver fibrosis is generally asymptomatic and patients may not present until they have advanced cirrhosis, when the scope for reversibility is limited. Identification of asymptomatic individuals at an early stage, is fundamental to reversing the rising toll of liver-related morbidity and mortality. Awareness of liver disease and the techniques for diagnosis is important for dermatologists, not only due to the burden of disease in the general population but also because some dermatology cohorts may have an elevated risk; for example the increased prevalence of metabolic syndrome and excess alcohol use in those with psoriasis and hidradenitis suppurativa, in addition to the use of potentially hepatotoxic drugs such as methotrexate...
December 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27994778/intrinsic-vertebral-markers-for-spinal-level-localization-in-anterior-cervical-spine-surgery-a-preliminary-report
#4
Deepak Kumar Jha, Anil Thakur, Mukul Jain, Arvind Arya, Chandrabhushan Tripathi, Rima Kumari, Suman Kushwaha
STUDY DESIGN: Prospective clinical study. PURPOSE: To observe the usefulness of anterior cervical osteophytes as intrinsic markers for spinal level localization (SLL) during sub-axial cervical spinal surgery via the anterior approach. OVERVIEW OF LITERATURE: Various landmarks, such as the mandibular angle, hyoid bone, thyroid cartilage, first cricoid ring, and C6 carotid tubercle, are used for gross cervical SLL; however, none are used during cervical spinal surgery via the anterior approach...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27913513/minimal-residual-disease-in-mantle-cell-lymphoma-insights-into-biology-and-impact-on-treatment
#5
Eva Hoster, Christiane Pott
Despite the recent substantial improvement of clinical outcome in mantle cell lymphoma (MCL), resistance to immunochemotherapy and common relapses are challenges for long-term tumor control. The assessment of minimal residual disease (MRD) by real-time quantitative polymerase chain reaction has emerged as a widely feasible and standardized tool for direct assessment of therapy-induced reduction of tumor burden and regrowth after cytotoxic treatment in MCL, with much improved sensitivity compared with conventional staging procedures...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27892808/self-reported-impulsivity-in-huntington-s-disease-patients-and-relationship-to-executive-dysfunction-and-reward-responsiveness
#6
Patricia L Johnson, Geoffrey F Potts, Juan Sanchez-Ramos, Cynthia R Cimino
INTRODUCTION: Few studies have directly investigated impulsivity in Huntington's disease (HD) despite known changes in dopaminergic and frontal functioning, changes that have been associated with impulsivity in other disorders and in the normal population. This study sought to further categorize impulsivity in HD through examining differences in self-reported impulsivity between community controls and HD patients, the relationship between executive dysfunction and impulsivity, and the relationship of a reward/punishment behavioral inhibition task in relation to these self-report measures...
November 28, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27872320/pott-s-disease-a-major-issue-for-an-unaccompanied-refugee-minor
#7
Cihan Papan, Ulrich von Both, Matthias Kappler, Birgit Kammer, Matthias Griese, Johannes Huebner
The incidence of TB in children in Germany has been on a rise since 2008, especially among foreign-born individuals. With rapidly increasing numbers of refugees from the numerous areas of conflict, this increase in incidence is not expected to halt, neither in Germany nor in Europe in general. We report a case of insufficient tracking in a 16-year-old unaccompanied refugee minor from Somalia who had a positive interferon γ release assay on arrival in Germany. No actions were undertaken, until 6 months later, an X-ray showed prominent hilar enlargement...
November 21, 2016: Thorax
https://www.readbyqxmd.com/read/27836047/a-study-of-leptospirosis-in-south-african-horses-and-associated-risk-factors
#8
V Simbizi, M N Saulez, A Potts, C Lötter, B Gummow
Most leptospiral infections in horses are asymptomatic; however, acute disease manifestations as well as reproductive failure and recurrent uveitis have been reported. In South Africa, the epidemiology of the disease in horses is not well documented. A serosurvey to determine what serovars were present in horses from Gauteng, KwaZulu-Natal and Western Cape Provinces and to get an estimate of the seroprevalence of leptospirosis was carried out from January 2013 until April 2014 with the assistance of four large equine hospitals located in these provinces...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27807470/a-bayesian-hierarchical-spatial-model-for-dental-caries-assessment-using-non-gaussian-markov-random-fields
#9
Ick Hoon Jin, Ying Yuan, Dipankar Bandyopadhyay
Research in dental caries generates data with two levels of hierarchy: that of a tooth overall and that of the different surfaces of the tooth. The outcomes often exhibit spatial referencing among neighboring teeth and surfaces, i.e., the disease status of a tooth or surface might be influenced by the status of a set of proximal teeth/surfaces. Assessments of dental caries (tooth decay) at the tooth level yield binary outcomes indicating the presence/absence of teeth, and trinary outcomes at the surface level indicating healthy, decayed, or filled surfaces...
2016: Annals of Applied Statistics
https://www.readbyqxmd.com/read/27709349/bathing-in-carbon-dioxide-enriched-water-alters-protein-expression-in-keratinocytes-of-skin-tissue-in-rats
#10
Julia Kälsch, Leona L Pott, Atsushi Takeda, Hideo Kumamoto, Dorothe Möllmann, Ali Canbay, Barbara Sitek, Hideo A Baba
Beneficial effects of balneotherapy using naturally occurring carbonated water (CO2 enriched) have been known since the Middle Ages. Although this therapy is clinically applied for peripheral artery disease and skin disorder, the underlying mechanisms are not fully elucidated.Under controlled conditions, rats were bathed in either CO2-enriched water (CO2 content 1200 mg/L) or tap water, both at 37 °C, for 10 min daily over 4 weeks. Proliferation activity was assessed by Ki67 immunohistochemistry of the epidermis of the abdomen...
October 5, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27701070/esmo-consensus-conference-on-malignant-lymphoma-general-perspectives-and-recommendations-for-prognostic-tools-in-mature-b-cell-lymphomas-and-chronic-lymphocytic-leukaemia
#11
M Ladetto, C Buske, M Hutchings, M Dreyling, G Gaidano, S Le Gouill, S Luminari, C Pott, A Zamò, E Zucca
The European Society for Medical Oncology (ESMO) consensus conference on mature B-cell lymphomas and chronic lymphocytic leukaemia (CLL) was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aim of the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (i) the elderly patient, (ii) prognostic factors suitable for clinical use and (iii) the 'ultra-high-risk' group...
December 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27677045/management-in-a-rehabilitation-department-in-pott-s-disease
#12
Emna Toulgui, Sonia Jemni, Samia Frioui, Nadia Lazreg, Sahbi Mtaouaa, Fayçal Khachnaoui
OBJECTIVE: Tuberculous spondylitis, or Pott's disease, is a public health problem in Tunisia, where it occurs as an endemic disease. It is the most common and most severe articular bone tuberculosis. It is responsible for a major handicap because of its location and its destructive nature. This work aims to assess the contribution of rehabilitation for patients with Pott's disease. MATERIAL/PATIENTS AND METHODS: A retrospective study that included 29 patients with Pott's disease and hospitalized in PMR Service...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27672456/reversal-of-a-suspected-paradoxical-reaction-to-zopiclone-with-flumazenil
#13
Zarah Jordahn, Cheme Andersen, Anne Marie Roust Aaberg, Frank Christian Pott
We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27670679/tuberculous-spondylitis-diagnosed-through-xpert-mtb-rif-assay-in-urine-a-case-report
#14
George Sikalengo, Adria Ramirez, Diana Faini, Kim Mwamelo, Manuel Battegay, Levan Jugheli, Christoph Hatz, Klaus Reither, Emilio Letang
BACKGROUND: Extrapulmonary tuberculosis (EPTB) is associated with high rates of morbidity and mortality. Diagnosis of EPTB is challenging in resource-limited settings due to difficulties in obtaining samples, as well as the paucibacillarity of the specimens. Skeletal tuberculosis accounts for 10-35 % of EPTB cases, with vertebral osteomyelitis (Pott's disease) representing 50 % of the cases. We present two cases of suspected Pott's disease, diagnosed through GeneXpert MTB/RIF assay in urine at a rural Tanzanian hospital...
September 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27664225/non-tuberculous-mycobacteria-mimic-of-mdr-tb-infection-in-pott-s-disease
#15
Manoj Kumar, Sheetal Verma, Tapan N Dhole, Raj Kumar
A 34 year-old woman presented with history of progressive back pain which was diagnosed as Pott's disease with recurrent paravertebral abscess, and had received a total of 23 months of antitubercular treatment for lumbar infection. The patient was non-responsive to treatment and was referred to a higher centre where the infection was finally identified as non-tuberculous mycobacterium (Mycobacterium fortuitum) by genotypic testing. The drugs were initiated according to results of drug susceptibility testing by the broth microdilution method...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27660720/coexistence-of-a-ghon-complex-pott-s-disease-and-hip-arthritis-in-a-child
#16
Ozgul Yigit, Meltem Erol, Ozlem Bostan Gayret, Isıl Ustun, Selami Ulas
INTRODUCTION: Tuberculosis remains a major public health problem in developing countries. Diagnosing extrapulmonary tuberculosis can be difficult, as it requires a higher index of suspicion than primary tuberculosis. Extrapulmonary tuberculosis may mimic malignancies and many other diseases, so it should be included in the differential diagnosis. Here, we present a case of extrapulmonary tuberculosis associated with Pott's disease and hip arthritis in a patient who recovered after 12 months of antituberculosis therapy...
July 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27614835/identification-of-a-haplotype-associated-with-cholesterol-deficiency-and-increased-juvenile-mortality-in-holstein-cattle
#17
S Kipp, D Segelke, S Schierenbeck, F Reinhardt, R Reents, C Wurmser, H Pausch, R Fries, G Thaller, J Tetens, J Pott, D Haas, B B Raddatz, M Hewicker-Trautwein, I Proios, M Schmicke, W Grünberg
Over the last decades, several genetic disorders have been discovered in cattle. However, the genetic background of disorders in calves is less reported. Recently, German cattle farmers reported on calves from specific matings with chronic diarrhea and retarded growth of unknown etiology. Affected calves did not respond to any medical treatment and died within the first months of life. These calves were underdeveloped in weight and showed progressive and severe emaciation despite of normal feed intake. Hallmark findings of the blood biochemical analysis were pronounced hypocholesterolemia and deficiency of fat-soluble vitamins...
September 7, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27613822/circulating-granulocyte-lifespan-in-compensated-alcohol-related-cirrhosis-a-pilot-study
#18
Jonathan R Potts, Neda Farahi, Sarah Heard, Edwin R Chilvers, Sumita Verma, Adrien M Peters
Although granulocyte dysfunction is known to occur in cirrhosis, in vivo studies of granulocyte lifespan have not previously been performed. The normal circulating granulocyte survival half-time (G - t½), determined using indium-111 ((111)In)-radiolabeled granulocytes, is ~7 h. In this pilot study, we aimed to measure the in vivo G - t½ in compensated alcohol-related cirrhosis. Sequential venous blood samples were obtained in abstinent subjects with alcohol-related cirrhosis over 24 h post injection (PI) of minimally manipulated (111)In-radiolabeled autologous mixed leukocytes...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27613721/primary-hyperparathyroidism-review-and-recommendations-on-evaluation-diagnosis-and-management-a-canadian-and-international-consensus
#19
REVIEW
A A Khan, D A Hanley, R Rizzoli, J Bollerslev, J E M Young, L Rejnmark, R Thakker, P D'Amour, T Paul, S Van Uum, M Zakaria Shrayyef, D Goltzman, S Kaiser, N E Cusano, R Bouillon, L Mosekilde, A W Kung, S D Rao, S K Bhadada, B L Clarke, J Liu, Q Duh, E Michael Lewiecki, F Bandeira, R Eastell, C Marcocci, S J Silverberg, R Udelsman, K Shawn Davison, J T Potts, M L Brandi, J P Bilezikian
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH)...
January 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27605320/pharmacist-prescribing-within-an-integrated-health-system-in-washington
#20
Roger Woolf, Amanda Locke, Catherine Potts
PURPOSE: Pharmacist prescribing as part of a collaborative drug therapy agreement (CDTA) within an integrated health system in Washington is described. SUMMARY: Virginia Mason Medical Center (VMMC) in Seattle, Washington, uses a team-based care model with broad-based CDTAs to provide quality patient care. The majority of patients are referred to the pharmacist after a diagnosis has been made and a clinical care plan has been started. The pharmacist manages the patient's care within his or her scope of practice as defined by state laws and further detailed by VMMC internal protocols...
September 15, 2016: American Journal of Health-system Pharmacy: AJHP
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