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https://www.readbyqxmd.com/read/29907737/paradoxical-reaction-in-a-patient-with-co-occurring-tuberculous-meningitis-and-pott-s-disease
#1
Talia Robledo-Gil, Kaoru Harada, Ichiro Ikuta, Merceditas Villanueva
BACKGROUND Paradoxical reactions to tuberculosis (TB) are clinical or radiological worsening of prior tuberculous lesions or the development of new lesions upon treatment with appropriate anti-tuberculosis therapy (ATT). This phenomenon has been described in both HIV-seropositive and HIV-seronegative patients. Although historically estimated to occur in 6-30% of HIV-seronegative patients with TB, the phenomenon is often under-recognized in the current era, particularly in countries of low TB prevalence. We describe a case of a TB paradoxical reaction affecting the CNS and spine in an HIV-seronegative individual who received clinical care in the U...
June 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29861049/relation-between-age-and-unplanned-readmissions-after-percutaneous-coronary-intervention-findings-from-the-nationwide-readmission-database
#2
Chun Shing Kwok, Sunil V Rao, Ian Gilchrist, Sara C Martinez, Fakhr Al Ayoubi, Jessica Potts, Muhammad Rashid, Evangelos Kontopantelis, Phyo K Myint, Mamas A Mamas
It is unclear how age affects rates and causes of unplanned early readmissions after percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact of age on readmissions after PCI. The primary outcomes were age-specific 30-day rates and causes of unplanned readmissions. A total of 2,294,345 procedures were analyzed with a 9.6% unplanned readmission rate within 30 days. Unplanned readmissions were 8.1%, 8.1%, 9...
April 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29846908/lesions-consistent-with-tuberculous-spondylitis-in-domestic-and-wild-swine-and-their-potential-use-as-a-model-for-pott-disease-in-humans
#3
Benedetta Amato, Maria Vitale, Maria Teresa Capucchio, Michele Fiasconaro, Elisabetta Gerace, Roberto Puleio, Vincenzo Di Marco Lo Presti
During a routine abattoir inspection of pig carcasses and control activities of hunted wildlife in 2013, 118 large white pigs Sus scrofa domesticus, 474 Nebrodi black pigs and 135 wild boars Sus scrofa scrofa were submitted to anatomopathological examination to evaluate the presence of tuberculosis-like lesions. Localized and generalized granulomatous lesions were detected with a prevalence of about 25% in large white pigs, 13% in Nebrodi black pigs and 8.15% in wild boars. Localized lesions involved mainly the submandibular lymph nodes, but when the disease was spread throughout the body, the inner organs and, also, in some cases, udders and/or bones were injured...
May 31, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29804641/anthropometry-based-equations-to-estimate-body-composition-a-suitable-alternative-in-renal-transplant-recipients-and-patients-with-nondialysis-dependent-kidney-disease
#4
Thomas J Wilkinson, Danielle Richler-Potts, Daniel G D Nixon, Jill Neale, Alice C Smith
OBJECTIVE: Chronic kidney disease (CKD) patients and renal transplant recipients (RTRs) are characterized by aberrant body composition such as muscle wasting and obesity. It is still unknown which is the most accurate method to estimate body composition in CKD. We investigated the validity of the Hume equation and bioelectrical impedance analysis (BIA) as an estimate of body composition against dual-energy X-ray absorptiometry (DXA) in a cohort of nondialysis dependent (NDD)-CKD and RTRs...
May 24, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29799774/epithelial-autophagy-controls-chronic-colitis-by-reducing-tnf-induced-apoptosis
#5
Johanna Pott, Kevin J Maloy
Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment...
May 25, 2018: Autophagy
https://www.readbyqxmd.com/read/29750993/mutation-of-the-na-k-atpase-atp1a1a-1-causes-qt-interval-prolongation-and-bradycardia-in-zebrafish
#6
Alexander Pott, Sarah Bock, Ina M Berger, Karen Frese, Tillman Dahme, Mirjam Kessler, Susanne Rinné, Niels Decher, Steffen Just, Wolfgang Rottbauer
The genetic underpinnings that orchestrate the vertebrate heart rate are not fully understood yet, but of high clinical importance, since diseases of cardiac impulse formation and propagation are common and severe human arrhythmias. To identify novel regulators of the vertebrate heart rate, we deciphered the pathogenesis of the bradycardia in the homozygous zebrafish mutant hiphop (hip) and identified a missense-mutation (N851K) in Na+ /K+ -ATPase α1-subunit (atp1a1a.1). N851K affects zebrafish Na+ /K+ -ATPase ion transport capacity, as revealed by in vitro pump current measurements...
May 8, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29748315/genetic-regulation-of-pcsk9-proprotein-convertase-subtilisin-kexin-type-9-plasma-levels-and-its-impact-on-atherosclerotic-vascular-disease-phenotypes
#7
Janne Pott, Valentin Schlegel, Andrej Teren, Katrin Horn, Holger Kirsten, Christina Bluecher, Juergen Kratzsch, Markus Loeffler, Joachim Thiery, Ralph Burkhardt, Markus Scholz
BACKGROUND: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is a novel strategy to treat hypercholesterolemia and reduce cardiovascular events. However, the potential role of circulating plasma PCSK9 concentrations as a diagnostic and predictive biomarker remains uncertain as of now. Here, we aimed to identify genetic variants associated with plasma PCSK9 and investigate possible causal effects on atherosclerotic vascular disease phenotypes. METHODS: We performed the first genome-wide association study of plasma PCSK9 levels in a cohort of suspected and confirmed coronary artery disease (LIFE-Heart; n=3290)...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29622145/burden-of-30-day-readmissions-after-percutaneous-coronary-intervention-in-833-344-patients-in-the-united-states-predictors-causes-and-cost-insights-from-the-nationwide-readmission-database
#8
Chun Shing Kwok, Sunil V Rao, Jessica E Potts, Evangelos Kontopantelis, Muhammad Rashid, Tim Kinnaird, Nick Curzen, James Nolan, Rodrigo Bagur, Mamas A Mamas
OBJECTIVES: This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI). BACKGROUND: Unplanned rehospitalizations following PCI carry significant burden to both patients and the local health care economy and are increasingly considered as an indicator of quality of care. METHODS: Patients undergoing PCI between 2013 and 2014 in the U...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29590547/ibrutinib-plus-venetoclax-for-the-treatment-of-mantle-cell-lymphoma
#9
COMPARATIVE STUDY
Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts
BACKGROUND: Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma. Complete response rates of 21% have been observed for each agent when administered as long-term continuous therapy. Preclinical models predict synergy in combination. METHODS: We conducted a single-group, phase 2 study of daily oral ibrutinib and venetoclax in patients, as compared with historical controls. Patients commenced ibrutinib monotherapy at a dose of 560 mg per day...
March 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29578031/the-unc-umn-baby-connectome-project-bcp-an-overview-of-the-study-design-and-protocol-development
#10
REVIEW
Brittany R Howell, Martin A Styner, Wei Gao, Pew-Thian Yap, Li Wang, Kristine Baluyot, Essa Yacoub, Geng Chen, Taylor Potts, Andrew Salzwedel, Gang Li, John H Gilmore, Joseph Piven, J Keith Smith, Dinggang Shen, Kamil Ugurbil, Hongtu Zhu, Weili Lin, Jed T Elison
The human brain undergoes extensive and dynamic growth during the first years of life. The UNC/UMN Baby Connectome Project (BCP), one of the Lifespan Connectome Projects funded by NIH, is an ongoing study jointly conducted by investigators at the University of North Carolina at Chapel Hill and the University of Minnesota. The primary objective of the BCP is to characterize brain and behavioral development in typically developing infants across the first 5 years of life. The ultimate goals are to chart emerging patterns of structural and functional connectivity during this period, map brain-behavior associations, and establish a foundation from which to further explore trajectories of health and disease...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29576927/encapsulated-cell-technology-based-delivery-of-a-complement-inhibitor-reduces-choroidal-neovascularization-in-a-mouse-model
#11
Balasubramaniam Annamalai, Nathaniel Parsons, Marwa Belhaj, Carlene Brandon, Jay Potts, Bärbel Rohrer
Purpose: Age-related macular degeneration (AMD) is a slowly progressing disease, and risk appears to be tied to an overactive complement system. We have previously demonstrated that mouse choroidal neovascularization (CNV) and smoke-induced ocular pathology can be reduced with an alternative pathway (AP) inhibitor fusion protein consisting of a complement receptor-2 fragment linked to the inhibitory domain of factor H (CR2-fH) when delivered systemically. Here we developed an experimental approach with genetically engineered encapsulated ARPE-19 cells to produce CR2-fH intravitreally...
March 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29559196/doppler-echocardiography-assessment-of-aortic-stiffness-in-female-adolescents-with-anorexia-nervosa
#12
Carolina A Escudero, James E Potts, Pei-Yoong Lam, Astrid M De Souza, Gerald J Mugford, George G S Sandor
BACKGROUND: Anorexia nervosa (AN) is associated with abnormalities in biomarkers of cardiovascular risk. Arterial stiffness, as measured by pulse-wave velocity (PWV), is also a risk factor for cardiovascular disease. The aims of this study were to determine the stiffness of the aorta in female adolescents with AN and to determine if either the severity or the type of AN was associated with PWV. METHODS: This was a retrospective case-control study. Adolescent patients with a clinical diagnosis of AN were included...
March 17, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29545075/interventional-therapies-in-pulmonary-hypertension
#13
Julio Sandoval
Despite advances in drug therapy, pulmonary hypertension-particularly arterial hypertension (PAH)-remains a fatal disease. Untreatable right heart failure (RHF) from PAH eventually ensues and remains a significant cause of death in these patients. Lowering pulmonary input impedance with different PAH-specific drugs is the obvious therapeutic target in RHF due to chronically increased afterload. However, potential clinical gain can also be expected from attempts to unload the right heart and increase systemic output...
March 12, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29541815/impact-of-the-right-ventricular-sokolow-lyon-index-in-children-with-idiopathic-pulmonary-arterial-hypertension
#14
Johannes Krämer, Felix Kreuzer, Michael Kaestner, Peter Bride, Fabian von Scheidt, Jannos Siaplaouras, Heiner Latus, Dietmar Schranz, Christian Apitz
Right ventricular (RV) hypertrophy is regarded as the adaptation on chronic RV pressure load in pulmonary hypertension. As the RV Sokolow-Lyon index (RVSLI) is an electrocardiographic marker of RV hypertrophy, we hypothesized that RVSLI might be able to reflect RV pressure load. Therefore, the purpose of this study was to characterize the diagnostic impact of the RVSLI in children with idiopathic pulmonary arterial hypertension (IPAH) in order to assess disease severity and to evaluate its value for the prediction of worse outcome...
March 14, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29494796/seroprevalence-of-hepatitis-e-virus-in-chronic-hepatitis-c-in-brazil
#15
Guilherme Bricks, Jorge Figueiredo Senise, Henrique Pott Junior, Giuliano Grandi, Amanda Passarini, Débora Bellini Caldeira, Dimas Carnaúba Junior, Hamilton Antonio Bonilha de Moraes, Celso Franscisco Hernandes Granato, Adauto Castelo
BACKGROUND AND AIMS: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. METHODS: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included...
March 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29464391/treatment-of-pediatric-pulmonary-hypertension
#16
REVIEW
Manish Aggarwal, R Mark Grady
Pulmonary hypertension (PH) is an increasingly recognized problem in children, particularly within tertiary pediatric hospitals. This increase is, in large part, due to ever improving survival among previously fatal conditions, such as extreme prematurity and complicated congenital heart disease. This increased recognition has paralleled burgeoning pharmacologic and interventional PH-specific treatment options. Unfortunately, most PH-specific therapies have not been tested in children with rigorous, randomized, controlled trials...
February 20, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29448978/effect-of-gender-on-unplanned-readmissions-after-percutaneous-coronary-intervention-from-the-nationwide-readmissions-database
#17
Chun Shing Kwok, Jessica Potts, Martha Gulati, Mirvat Alasnag, Muhammad Rashid, Ahmad Shoaib, Muhammad Ayyaz Ul Haq, Rodrigo Bagur, Mamas Andreas Mamas
Women who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared with men, but it is unknown whether gender affects early unplanned rehospitalization. We analyzed 832,753 patients who underwent PCI from 2013 to 2014 in the Nationwide Readmissions Database. We compared gender differences in incidences, predictors, causes, and cost of unplanned 30-day readmissions and examined the effect of co-morbidity. A total of 832,753 men and women who survived the index PCI and were not admitted for a planned readmission were included in the analysis...
April 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29447690/autophagy-suicide-prevention-hotline-for-the-gut-epithelium
#18
COMMENT
Mayara Grizotte-Lake, Shipra Vaishnava
Autophagy is genetically associated with inflammatory bowel disease (IBD); however, its role remains unclear in disease pathogenesis. Three recent studies reveal a novel cytoprotective role of autophagy during viral, bacterial, and protozoan-triggered IBD (Burger et al., 2018; Matsuzawa-Ishimoto et al., 2017; Pott et al., 2018).
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29429127/tissue-and-strain-specific-effects-of-a-genotoxic-carcinogen-1-3-butadiene-on-chromatin-and-transcription
#19
Jennifer W Israel, Grace A Chappell, Jeremy M Simon, Sebastian Pott, Alexias Safi, Lauren Lewis, Paul Cotney, Hala S Boulos, Wanda Bodnar, Jason D Lieb, Gregory E Crawford, Terrence S Furey, Ivan Rusyn
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanisms. In this study, we hypothesized that baseline variability in chromatin organization and transcription profiles among various tissues and mouse strains influence the outcome of exposure to the DNA damaging chemical 1,3-butadiene...
February 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29423258/an-intervention-for-pulmonary-rehabilitators-to-develop-a-social-identity-for-patients-attending-exercise-rehabilitation-a-feasibility-and-pilot-randomised-control-trial-protocol
#20
Andrew R Levy, Bashir Matata, Sam Pilsworth, Adrian Mcgonigle, Lyndsey Wigelsworth, Linda Jones, Nicola Pott, Max Bettany, Adrian W Midgley
Background: Chronic obstructive pulmonary disease (COPD) is a degenerative condition that can impair health-related quality of life (HRQoL). A number of self-management interventions, employing a variety of behavioural change techniques (BCTs), have been adopted to improve HRQoL for COPD patients. However, a lack of attention has been given to group management interventions with an emphasis on incorporating BCTs into rehabilitators' practice. This study aims to pilot and feasibly explore a social identity group management intervention, delivered by COPD rehabilitation staff to patients attending exercise pulmonary rehabilitation...
2018: Pilot and Feasibility Studies
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