keyword
MENU ▼
Read by QxMD icon Read
search

pott disease

keyword
https://www.readbyqxmd.com/read/29622145/burden-of-30-day-readmissions-after-percutaneous-coronary-intervention-in-833-344-patients-in-the-united-states-predictors-causes-and-cost-insights-from-the-nationwide-readmission-database
#1
Chun Shing Kwok, Sunil V Rao, Jessica E Potts, Evangelos Kontopantelis, Muhammad Rashid, Tim Kinnaird, Nick Curzen, James Nolan, Rodrigo Bagur, Mamas A Mamas
OBJECTIVES: This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI). BACKGROUND: Unplanned rehospitalizations following PCI carry significant burden to both patients and the local health care economy and are increasingly considered as an indicator of quality of care. METHODS: Patients undergoing PCI between 2013 and 2014 in the U...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29590547/ibrutinib-plus-venetoclax-for-the-treatment-of-mantle-cell-lymphoma
#2
COMPARATIVE STUDY
Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts
BACKGROUND: Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma. Complete response rates of 21% have been observed for each agent when administered as long-term continuous therapy. Preclinical models predict synergy in combination. METHODS: We conducted a single-group, phase 2 study of daily oral ibrutinib and venetoclax in patients, as compared with historical controls. Patients commenced ibrutinib monotherapy at a dose of 560 mg per day...
March 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29578031/the-unc-umn-baby-connectome-project-bcp-an-overview-of-the-study-design-and-protocol-development
#3
REVIEW
Brittany R Howell, Martin A Styner, Wei Gao, Pew-Thian Yap, Li Wang, Kristine Baluyot, Essa Yacoub, Geng Chen, Taylor Potts, Andrew Salzwedel, Gang Li, John H Gilmore, Joseph Piven, J Keith Smith, Dinggang Shen, Kamil Ugurbil, Hongtu Zhu, Weili Lin, Jed T Elison
The human brain undergoes extensive and dynamic growth during the first years of life. The UNC/UMN Baby Connectome Project (BCP), one of the Lifespan Connectome Projects funded by NIH, is an ongoing study jointly conducted by investigators at the University of North Carolina at Chapel Hill and the University of Minnesota. The primary objective of the BCP is to characterize brain and behavioral development in typically developing infants across the first 5 years of life. The ultimate goals are to chart emerging patterns of structural and functional connectivity during this period, map brain-behavior associations, and establish a foundation from which to further explore trajectories of health and disease...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29576927/encapsulated-cell-technology-based-delivery-of-a-complement-inhibitor-reduces-choroidal-neovascularization-in-a-mouse-model
#4
Balasubramaniam Annamalai, Nathaniel Parsons, Marwa Belhaj, Carlene Brandon, Jay Potts, Bärbel Rohrer
Purpose: Age-related macular degeneration (AMD) is a slowly progressing disease, and risk appears to be tied to an overactive complement system. We have previously demonstrated that mouse choroidal neovascularization (CNV) and smoke-induced ocular pathology can be reduced with an alternative pathway (AP) inhibitor fusion protein consisting of a complement receptor-2 fragment linked to the inhibitory domain of factor H (CR2-fH) when delivered systemically. Here we developed an experimental approach with genetically engineered encapsulated ARPE-19 cells to produce CR2-fH intravitreally...
March 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29559196/doppler-echocardiography-assessment-of-aortic-stiffness-in-female-adolescents-with-anorexia-nervosa
#5
Carolina A Escudero, James E Potts, Pei-Yoong Lam, Astrid M De Souza, Gerald J Mugford, George G S Sandor
BACKGROUND: Anorexia nervosa (AN) is associated with abnormalities in biomarkers of cardiovascular risk. Arterial stiffness, as measured by pulse-wave velocity (PWV), is also a risk factor for cardiovascular disease. The aims of this study were to determine the stiffness of the aorta in female adolescents with AN and to determine if either the severity or the type of AN was associated with PWV. METHODS: This was a retrospective case-control study. Adolescent patients with a clinical diagnosis of AN were included...
March 17, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29545075/interventional-therapies-in-pulmonary-hypertension
#6
Julio Sandoval
Despite advances in drug therapy, pulmonary hypertension-particularly arterial hypertension (PAH)-remains a fatal disease. Untreatable right heart failure (RHF) from PAH eventually ensues and remains a significant cause of death in these patients. Lowering pulmonary input impedance with different PAH-specific drugs is the obvious therapeutic target in RHF due to chronically increased afterload. However, potential clinical gain can also be expected from attempts to unload the right heart and increase systemic output...
March 12, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29541815/impact-of-the-right-ventricular-sokolow-lyon-index-in-children-with-idiopathic-pulmonary-arterial-hypertension
#7
Johannes Krämer, Felix Kreuzer, Michael Kaestner, Peter Bride, Fabian von Scheidt, Jannos Siaplaouras, Heiner Latus, Dietmar Schranz, Christian Apitz
Right ventricular (RV) hypertrophy is regarded as the adaptation on chronic RV pressure load in pulmonary hypertension. As the RV Sokolow-Lyon index (RVSLI) is an electrocardiographic marker of RV hypertrophy, we hypothesized that RVSLI might be able to reflect RV pressure load. Therefore, the purpose of this study was to characterize the diagnostic impact of the RVSLI in children with idiopathic pulmonary arterial hypertension (IPAH) in order to assess disease severity and to evaluate its value for the prediction of worse outcome...
March 14, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29494796/seroprevalence-of-hepatitis-e-virus-in-chronic-hepatitis-c-in-brazil
#8
Guilherme Bricks, Jorge Figueiredo Senise, Henrique Pott Junior, Giuliano Grandi, Amanda Passarini, Débora Bellini Caldeira, Dimas Carnaúba Junior, Hamilton Antonio Bonilha de Moraes, Celso Franscisco Hernandes Granato, Adauto Castelo Filho
BACKGROUND AND AIMS: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. METHODS: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included...
February 26, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29464391/treatment-of-pediatric-pulmonary-hypertension
#9
REVIEW
Manish Aggarwal, R Mark Grady
Pulmonary hypertension (PH) is an increasingly recognized problem in children, particularly within tertiary pediatric hospitals. This increase is, in large part, due to ever improving survival among previously fatal conditions, such as extreme prematurity and complicated congenital heart disease. This increased recognition has paralleled burgeoning pharmacologic and interventional PH-specific treatment options. Unfortunately, most PH-specific therapies have not been tested in children with rigorous, randomized, controlled trials...
February 20, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29448978/effect-of-gender-on-unplanned-readmissions-after-percutaneous-coronary-intervention-from-the-nationwide-readmissions-database
#10
Chun Shing Kwok, Jessica Potts, Martha Gulati, Mirvat Alasnag, Muhammad Rashid, Ahmad Shoaib, Muhammad Ayyaz Ul Haq, Rodrigo Bagur, Mamas Andreas Mamas
Women who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared with men, but it is unknown whether gender affects early unplanned rehospitalization. We analyzed 832,753 patients who underwent PCI from 2013 to 2014 in the Nationwide Readmissions Database. We compared gender differences in incidences, predictors, causes, and cost of unplanned 30-day readmissions and examined the effect of co-morbidity. A total of 832,753 men and women who survived the index PCI and were not admitted for a planned readmission were included in the analysis...
April 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29447690/autophagy-suicide-prevention-hotline-for-the-gut-epithelium
#11
Mayara Grizotte-Lake, Shipra Vaishnava
Autophagy is genetically associated with inflammatory bowel disease (IBD); however, its role remains unclear in disease pathogenesis. Three recent studies reveal a novel cytoprotective role of autophagy during viral, bacterial, and protozoan-triggered IBD (Burger et al., 2018; Matsuzawa-Ishimoto et al., 2017; Pott et al., 2018).
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29429127/tissue-and-strain-specific-effects-of-a-genotoxic-carcinogen-1-3-butadiene-on-chromatin-and-transcription
#12
Jennifer W Israel, Grace A Chappell, Jeremy M Simon, Sebastian Pott, Alexias Safi, Lauren Lewis, Paul Cotney, Hala S Boulos, Wanda Bodnar, Jason D Lieb, Gregory E Crawford, Terrence S Furey, Ivan Rusyn
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanisms. In this study, we hypothesized that baseline variability in chromatin organization and transcription profiles among various tissues and mouse strains influence the outcome of exposure to the DNA damaging chemical 1,3-butadiene...
February 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29423258/an-intervention-for-pulmonary-rehabilitators-to-develop-a-social-identity-for-patients-attending-exercise-rehabilitation-a-feasibility-and-pilot-randomised-control-trial-protocol
#13
Andrew R Levy, Bashir Matata, Sam Pilsworth, Adrian Mcgonigle, Lyndsey Wigelsworth, Linda Jones, Nicola Pott, Max Bettany, Adrian W Midgley
Background: Chronic obstructive pulmonary disease (COPD) is a degenerative condition that can impair health-related quality of life (HRQoL). A number of self-management interventions, employing a variety of behavioural change techniques (BCTs), have been adopted to improve HRQoL for COPD patients. However, a lack of attention has been given to group management interventions with an emphasis on incorporating BCTs into rehabilitators' practice. This study aims to pilot and feasibly explore a social identity group management intervention, delivered by COPD rehabilitation staff to patients attending exercise pulmonary rehabilitation...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29396245/combined-immunosuppression-and-radiotherapy-in-thyroid-eye-disease-cirted-a-multicentre-2-%C3%A3-2-factorial-double-blind-randomised-controlled-trial
#14
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
April 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29395691/pott-s-disease-in-a-patient-with-subtle-red-flags
#15
Lauren M Cantwell, John C Perkins, David C V Keyes
BACKGROUND: Tuberculosis (TB) is now rare in developed countries; however, it is an important diagnosis for the Emergency Physician to be able to make. Classically thought of as a respiratory disease, TB can present in other ways, making it more challenging to recognize. CASE REPORT: We report the case of a 41-year-old woman who presented to the Emergency Department with a 4-week history of back pain. A diagnosis of T12 osteomyelitis and right psoas muscle abscess was made after magnetic resonance imaging...
January 26, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29386725/tubercular-spondylitis-a-review-of-mri-findings-in-80-cases
#16
Vinay K Maurya, Pankaj Sharma, R Ravikumar, J Debnath, Vivek Sharma, Satyabrat Srikumar, Mukul Bhatia
Background: Tuberculosis of spine is known as tubercular spondylitis or Pott's spine. The vertebral involvement leads to various pathological processes such as abscess formation, cord compression, and gibbus deformity. Magnetic Resonance Imaging (MRI) is the imaging modality of choice which not only helps in diagnosing a case of Pott's spine but also gives valuable information about its impending complications, thereby, aiding in management of these cases. Methods: In this study, MRI scans of 80 proven cases of tubercular spondylitis were studied retrospectively for the various pathological processes affecting the spine...
January 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29378738/pott-s-disease-associated-with-large-and-multiple-abscesses-in-a-30-year-old-migrant-from-chad
#17
Anne Conrad, Tristan Ferry, Florence Ader, Florent Valour
No abstract text is available yet for this article.
January 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29358084/intestinal-epithelial-cell-autophagy-is-required-to-protect-against-tnf-induced-apoptosis-during-chronic-colitis-in-mice
#18
Johanna Pott, Agnieszka Martyna Kabat, Kevin Joseph Maloy
Genome-wide association studies have linked polymorphisms in the autophagy gene ATG16L1 with susceptibility to inflammatory bowel disease (IBD). However, the cell-type-specific effects of autophagy on the regulation of chronic intestinal inflammation have not been investigated. Here, we assessed the effect of myeloid-specific or intestinal epithelial cell (IEC)-specific deletion of Atg16l1 on chronic colitis triggered by the intestinal opportunistic pathogen Helicobacter hepaticus in mice. Although Atg16l1 deficiency in myeloid cells had little effect on disease, mice selectively lacking Atg16l1 in IECs (Atg16l1VC) developed severely exacerbated pathology, accompanied by elevated pro-inflammatory cytokine secretion and increased IEC apoptosis...
January 17, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29358061/pott-s-disease-resulting-in-complete-cervical-vertebral-destruction
#19
Jeffrey H Walden, Jeremy Schmitz
Skeletal tuberculosis, otherwise known as Pott's disease, has been recognized for centuries. Although typically diagnosed in citizens from countries with endemic tuberculosis, long-term workers in these regions, such as military deployees, can also acquire the disease. We present a case report of a military veteran presenting with neck pain and initially diagnosed with cervical disc disease. The patient's pain progressed to the point of developing paresthesias in his bilateral upper extremities. Eventually, cervical spine radiographs were obtained that revealed complete cervical vertebral body destruction from spinal tuberculosis...
March 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29322158/archaeological-evidence-for-pott-s-disease-on-historical-populations-tomb-05-at-the-roman-circus-maqbara-as-an-example-of-social-solidarity-toledo-spain
#20
Arturo Ruiz-Taboada, Isabel Molero Rodrigo
World societies can often be characterized by their attitude towards elderly and illness. It is well known that most cultures were concerned about those who were not able to produce and take care of themselves. This brings to the development of social processes that involve such individuals within the community, resulting in groups who stick together, and at last, ensuring the survival of the group. The contextualization of many of those social processes might be studied through Physical Anthropology and Paleopathology...
February 1, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
keyword
keyword
64821
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"