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Janelle Guirguis-Blake, Gina A Keppel, John Holmes, Rex W Force, William Kriegsman, Laura-Mae Baldwin
Background: Patients with chronic kidney disease (CKD) are at high risk for adverse drug events related to medication dosing errors and prescriptions for relatively contraindicated medications, such as non-steroidal anti-inflammatory drugs (NSAIDs). Objectives: To examine the scope of and variation in prescribing relatively contraindicated medications and medications above the recommended dose levels among patients with stage III/IV CKD in primary care practice...
February 26, 2018: Family Practice
Catherine Rex, Marjorie H Charlop, Vicki Spector
In the present study, we used a multiple baseline design across participants to assess the efficacy of a video modeling intervention to teach six children with autism spectrum disorder (ASD) to assertively respond to bullying. During baseline, the children made few appropriate responses upon viewing video clips of bullying scenarios. During the video modeling intervention, participants viewed videos of models assertively responding to three types of bullying: physical, verbal bullying, and social exclusion...
March 7, 2018: Journal of Autism and Developmental Disorders
Timothy J Clough, Gary J Lanigan, Cecile A M de Klein, Md Sainur Samad, Sergio E Morales, David Rex, Lars R Bakken, Charlotte Johns, Leo M Condron, Jim Grant, Karl G Richards
A correction has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 7, 2018: Scientific Reports
Yanfei Deng, Guiting Huang, Lingxiu Zou, Tianying Nong, Xiaoling Yang, Jiayu Cui, Yingming Wei, Sufang Yang, Deshun Shi
Amniotic mesenchymal stem cells (AMSCs) from livestock are valuable resources for animal reproduction and veterinary therapeutic. The purpose of this study is to explore a suitable way to isolate and culture the buffalo AMSCs (bAMSCs), and to identify their biological characteristics. Digestion with a combination of trypsin-EDTA and collagenase type I could obtain pure bAMSCs more effectively than trypsin-EDTA or collagenase type I alone. bAMSCs could proliferate steadily in vitro culture and exhibited fibroblastic-like morphology in vortex-shaped colony...
March 8, 2018: Journal of Veterinary Medical Science
Michael D Deel, Katherine K Slemmons, Ashley R Hinson, Katia C Genadry, Breanne A Burgess, Lisa E S Crose, Nina Kuprasertkul, Kristianne M Oristian, Rex C Bentley, Corinne M Linardic
PURPOSE: Alveolar rhabdomyosarcoma (aRMS) is a childhood soft tissue sarcoma driven by the signature PAX3-FOXO1 (P3F) fusion gene. 5-year survival for aRMS is <50%, with no improvement in over four decades. Although the transcriptional co-activator TAZ is oncogenic in carcinomas, the role of TAZ in sarcomas is poorly understood. The aim of this study was to investigate the role of TAZ in P3F-aRMS tumorigenesis. EXPERIMENTAL DESIGN: After determining from public datasets that TAZ is upregulated in human aRMS transcriptomes, we evaluated whether TAZ is also upregulated in our myoblast-based model of P3F-initiated tumorigenesis, and performed IHC staining of 63 human aRMS samples from tissue microarrays...
March 7, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Jon S Patricios, Clare L Ardern, Michael David Hislop, Mark Aubry, Paul Bloomfield, Carolyn Broderick, Patrick Clifton, Ruben J Echemendia, Richard G Ellenbogen, Éanna Cian Falvey, Gordon Ward Fuller, Julie Grand, Dallas Hack, Peter Rex Harcourt, David Hughes, Nathan McGuirk, Willem Meeuwisse, Jeffrey Miller, John T Parsons, Simona Richiger, Allen Sills, Kevin B Moran, Jenny Shute, Martin Raftery
The 2017 Berlin Concussion in Sport Group Consensus Statement provides a global summary of best practice in concussion prevention, diagnosis and management, underpinned by systematic reviews and expert consensus. Due to their different settings and rules, individual sports need to adapt concussion guidelines according to their specific regulatory environment. At the same time, consistent application of the Berlin Consensus Statement's themes across sporting codes is likely to facilitate superior and uniform diagnosis and management, improve concussion education and highlight collaborative research opportunities...
March 2, 2018: British Journal of Sports Medicine
Stig Andersen, Paneeraq Noahsen, Karsten F Rex, Inuuteq Fleischer, Nadja Albertsen, Marit E Jørgensen, Louise K Schæbel, Mogens B Laursen
Ca homoeostasis is important to human health and tightly controlled by powerful hormonal mechanisms that display ethnic variation. Ethnic variations could occur also in Arctic populations where the traditional Inuit diet is low in Ca and sun exposure is limited. We aimed to assess factors important to parathyroid hormone (PTH) and Ca in serum in Arctic populations. We included Inuit and Caucasians aged 50-69 years living in the capital city in West or in rural East Greenland. Lifestyle factors were assessed by questionnaires...
February 2018: British Journal of Nutrition
Karsten Baumgärtel, Andrea Green, Diana Hornberger, Jennifer Lapira, Christopher Rex, Damian G Wheeler, Marco Peters
The retrosplenial cortex (RSC) plays a critical role in episodic memory, but the molecular mechanisms governing plasticity in this structure are poorly understood. Diverse studies have demonstrated a role for RSC in acquisition, early consolidation and retrieval similar to the hippocampus (HC), as well as in systems consolidation similar to the anterior cingulate cortex. Here, we asked whether established molecular and structural substrates of memory consolidation in the HC also engage in RSC shortly after learning...
March 1, 2018: Scientific Reports
Ayodele Gomih, Jennifer S Smith, Kari E North, Michael G Hudgens, Wendy R Brewster, Zhiqing Huang, David Skaar, Fidel Valea, Rex C Bentley, Adriana C Vidal, Rachel L Maguire, Randy L Jirtle, Susan K Murphy, Cathrine Hoyo
The role of host epigenetic mechanisms in the natural history of low-grade cervical intraepithelial neoplasia (CIN1) is not well characterized. We explored differential methylation of imprinted gene regulatory regions as predictors of the risk of CIN1 regression. A total of 164 patients with CIN1 were recruited from 10 Duke University clinics for the CIN Cohort Study. Participants had colposcopies at enrollment and up to five follow-up visits over three years. DNA was extracted from exfoliated cervical cells for methylation quantitation at CpG (cytosine-phosphate-guanine) sites and human papillomavirus (HPV) genotyping...
February 28, 2018: International Journal of Cancer. Journal International du Cancer
Temidayo Fadelu, Sui Zhang, Donna Niedzwiecki, Xing Ye, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al B Benson, Daniel M Atienza, Michael Messino, Hedy L Kindler, Alan Venook, Shuji Ogino, Kimmie Ng, Kana Wu, Walter Willett, Edward Giovannucci, Jeffrey Meyerhardt, Ying Bao, Charles S Fuchs
Purpose Observational studies have reported increased colon cancer recurrence and mortality in patients with states of hyperinsulinemia, including type 2 diabetes, obesity, sedentary lifestyle, and high glycemic load diet. Nut intake has been associated with a lower risk of type 2 diabetes, metabolic syndrome, and insulin resistance. However, the effect of nut intake on colon cancer recurrence and survival is not known. Patients and Methods We conducted a prospective, observational study of 826 eligible patients with stage III colon cancer who reported dietary intake on food frequency questionnaires while enrolled onto a randomized adjuvant chemotherapy trial...
February 28, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Yu-Ming Huang, J Andrew McCammon, Yinglong Miao
Through adding a harmonic boost potential to smooth the system potential energy surface, Gaussian accelerated molecular dynamics (GaMD) provides enhanced sampling and free energy calculation of biomolecules without the need of predefined reaction coordinates. This work continues to improve the acceleration power and energy reweighting of the GaMD by combining the GaMD with replica exchange algorithms. Two versions of replica exchange GaMD (rex-GaMD) are presented: force constant rex-GaMD and threshold energy rex-GaMD...
February 28, 2018: Journal of Chemical Theory and Computation
Anna Bal-Price, Helena T Hogberg, Kevin M Crofton, Mardas Daneshian, Rex E FitzGerald, Ellen Fritsche, Tuula Heinonen, Susanne Hougaard Bennekou, Stefanie Klima, Aldert H Piersma, Magdalini Sachana, Timothy J Shafer, Andrea Terron, Florianne Monnet-Tschudi, Barbara Viviani, Tanja Waldmann, Remco H S Westerink, Martin F Wilks, Hilda Witters, Marie-Gabrielle Zurich, Marcel Leist
Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The field of developmental neurotoxicity (DNT) testing is used to exemplify the application of readiness criteria. The costs and number of untested chemicals are overwhelming for in vivo DNT testing. Thus, there is a need for inexpensive, high-throughput NAMs, to obtain initial information on potential hazards, and to allow prioritization for further testing...
February 23, 2018: ALTEX
Jee-Wei Emily Chen, Jan Lumibao, Audrey Blazek, H Rex Gaskins, Brendan Harley
Glioblastoma (GBM) is the most common, aggressive, and deadly form of adult brain cancer, and is associated with a short survival rate (median 12-15 months, 5+ year less than 5%). The complex tumor microenvironment includes matrix transitions at the tumor margin, such as gradations in hyaluronic acid (HA). In addition, metabolic stress induced by decreased oxygen content across the tumor may contribute to tumor progression. However, cross-talk between matrix composition and metabolic stress remains unclear...
February 27, 2018: Biomaterials Science
Benedikt H Siegler, Steffen Rex, Rolf Rossaint, Markus A Weigand
No abstract text is available yet for this article.
April 2018: European Journal of Anaesthesiology
Leila Mousazadeh, Effat Alizadeh, Nosratollah Zarghami, Shahryar Hashemzadeh, Sedigheh Fekri Aval, Leili Hasanifard, Roya Herizchi
BACK GROUND: Adipose tissue derived mesenchymal stem cells (ASCs) have unique potential for regenerative cell therapies. However, during ex-vivo cultivation, they undergo considerable quality loss regarding their phenotypic properties, stemness genes expression and differentiation potential. Recent studies reported that the loss of stemness properties of MSCs is a result of chromatin histone deacetylations through in-vitro cultivation. The present work aimed to study the effect of Trapoxin A (TPX) as a histone deacetylase inhibitor (HDACi) on overall stemness properties of ASCs...
February 26, 2018: Drug Research
Jiayu Chen, Vince D Calhoun, Dongdong Lin, Nora I Perrone-Bizzozero, Juan R Bustillo, Godfrey D Pearlson, Steven G Potkin, Theo G M van Erp, Fabio Macciardi, Stefan Ehrlich, Beng-Choon Ho, Scott R Sponheim, Lei Wang, Julia M Stephen, Andrew R Mayer, Faith M Hanlon, Rex E Jung, Brett A Clementz, Matcheri S Keshavan, Elliot S Gershon, John A Sweeney, Carol A Tamminga, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Jing Sui, Yuhui Du, Jessica A Turner, Jingyu Liu
Genetic factors are known to influence both risk for schizophrenia (SZ) and variation in brain structure. A pressing question is whether the genetic underpinnings of brain phenotype and the disorder overlap. Using multivariate analytic methods and focusing on 1,402 common single-nucleotide polymorphisms (SNPs) mapped from the Psychiatric Genomics Consortium (PGC) 108 regions, in 777 discovery samples, we identified 39 SNPs to be significantly associated with SZ-discriminating gray matter volume (GMV) reduction in inferior parietal and superior temporal regions...
February 21, 2018: Schizophrenia Bulletin
Rajeev Khanna, Shiv Kumar Sarin
BACKGROUND: Idiopathic portal hypertension (IPH) and extrahepatic portal venous obstruction (EHPVO) are non-cirrhotic vascular causes of portal hypertension (PHT). Variceal bleed and splenomegaly are the commonest presentations. AIM: The present review is intended to provide the existing literature on etiopathogenesis, clinical profile, diagnosis, natural history and management of IPH and EHPVO. RESULTS: IPH and EHPVO are both characterized by normal hepatic venous pressure gradient, moderate to massive splenomegaly with preserved liver synthetic functions...
February 20, 2018: Hepatology International
Simona Volpi, Carol Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Howard J Jacob, Melpomeni Kasapi, Howard L McLeod, Dan M Roden, Marc S Williams, Eric D Green, Laura Lyman Rodriguez, Samuel Aronson, Larisa H Cavallari, Joshua C Denny, Lynn Dressler, Julie A Johnson, Teri E Klein, J Steven Leeder, Micheline Piquette-Miller, Minoli Perera, Laura J Rasmussen-Torvik, Heidi L Rehm, Marylyn D Ritchie, Todd C Skaar, Nikhil Wagle, Richard Weinshilboum, Kristin W Weitzel, Robert Wildin, John Wilson, Teri A Manolio, Mary V Relling
Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions. Matching patients to the drugs that are most likely to be effective and least likely to cause harm is the goal of effective therapeutics. Pharmacogenomics (PGx) holds the promise of precision medicine through elucidating the genetic determinants responsible for pharmacological outcomes and using them to guide drug selection and dosing...
February 20, 2018: Clinical Pharmacology and Therapeutics
Thomas Dewers, Jason E Heath, Charles R Bryan, Joseph T Mang, Rex Paul Hjelm, Mei Ding, Mark Taylor
Results of oedometric consolidation experiments linked with small-angle neutron scattering (SANS) measurements are presented, using SWy-2 Wyoming bentonite clay in dry and water-bearing N2 and CO2 atmospheres. Oedometric SANS involves deforming a porous sample under uniaxial strain conditions with applied axial force and internal pore pressure control, and combines with SANS for in situ observation of pore structure evolution and interaction. Scattering from both interlayer (clay intra-aggregate) and free (inter-aggregate) pores is observed, showing decreasing pore size with dry consolidation and interactions between interlayer and free pore types with swelling and consolidation...
February 19, 2018: Environmental Science & Technology
Evelien Dekker, Douglas K Rex
Colorectal cancer (CRC) is amongst the most commonly diagnosed cancers and causes of death from cancer across the world. CRC can, however, be detected in asymptomatic patients at a curable stage, and several studies have shown lower mortality among patients who undergo screening compared to those who do not. Using colonoscopy in CRC screening also results in the detection of precancerous polyps that can be directly removed during the procedure, thereby reducing the incidence of cancer. In the past decade, convincing evidence has appeared that the effectiveness of colonoscopy as CRC prevention tool is associated with the quality of the procedure...
February 15, 2018: Gastroenterology
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