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https://www.readbyqxmd.com/read/29772446/does-interparental-conflict-decrease-following-changes-in-observed-parenting-from-a-preventive-intervention-program
#1
Alexandra D W Sullivan, Justin Parent, Rex Forehand, Bruce E Compas
Interparental conflict, which is common among families where a parent has a history of Major Depressive Disorder, is associated with deficits in parenting. Models of family functioning propose that interparental conflict and parenting behaviors are transactional in nature. Given the interdependent nature of family systems, increases in positive parenting practices may lead to subsequent decreases in interparental conflict. The current study was a secondary analysis of data from a preventive intervention to improve parenting, child coping skills, and child behavior in families with a history of parental depression...
May 7, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29769348/discovery-and-sequence-analysis-of-four-deltacoronaviruses-from-birds-in-the-middle-east-suggest-interspecies-jumping-and-recombination-as-potential-mechanism-for-avian-to-avian-and-avian-to-mammalian-transmission
#2
Susanna K P Lau, Emily Y M Wong, Chi-Ching Tsang, Syed Shakeel Ahmed, Rex K H Au-Yeung, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
The emergence of Middle East respiratory syndrome showed once again that coronaviruses (CoVs) in animals are potential source for epidemics in humans. To explore the diversity of deltacoronaviruses in animals in the Middle East, we tested fecal samples from 1,356 mammals and birds in Dubai. Four novel deltacoronaviruses were detected from eight birds of four species by RT-PCR: FalCoV UAE-HKU27 from a falcon, HouCoV UAE-HKU28 from a houbara bustard, PiCoV UAE-HKU29 from a pigeon and QuaCoV UAE-HKU30 from five quails...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769287/the-protective-role-of-macrophage-migration-inhibitory-factor-in-acute-kidney-injury-after-cardiac-surgery
#3
Christian Stoppe, Luisa Averdunk, Andreas Goetzenich, Josefin Soppert, Arnaud Marlier, Sandra Kraemer, Jil Vieten, Mark Coburn, Ana Kowark, Bong-Song Kim, Gernot Marx, Steffen Rex, Akinobu Ochi, Lin Leng, Gilbert Moeckel, Andreas Linkermann, Omar El Bounkari, Alexander Zarbock, Jürgen Bernhagen, Sonja Djudjaj, Richard Bucala, Peter Boor
Acute kidney injury (AKI) represents the most frequent complication after cardiac surgery. Macrophage migration inhibitory factor (MIF) is a stress-regulating cytokine that was shown to protect the heart from myocardial ischemia-reperfusion injury, but its role in the pathogenesis of AKI remains unknown. In an observational study, serum and urinary MIF was quantified in 60 patients scheduled for elective conventional cardiac surgery with the use of cardiopulmonary bypass. Cardiac surgery triggered an increase in MIF serum concentrations, and patients with high circulating MIF (>median) 12 hours after surgery had a significantly reduced risk of developing AKI (relative risk reduction, 72...
May 16, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29767511/low-dose-arsenic-trioxide-modulates-the-differentiation-of-mouse-embryonic-stem-cells
#4
Wenlin Yuan, Jun Chen, Hongren Huang, Zhihui Cai, Qinjie Ling, Feng Huang, Zhi Huang
Arsenic (As) is a well-known environmental pollutant,while arsenic trioxide (ATO) has been proven to be an effective treatment for acute promyelocytic leukemia, however, the mechanism underlying its dual effects is not fully understood.Embryonic stem cells (ESCs) appear properties of stemness and serve as a popular model to investigate epigenetic modifiers includingenvironmental pollutants.Herein, the effect of low dose ATO on differentiation were evaluatedin vitro using a mouse ESCs (mESCs) cell line, CGR8...
May 16, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29766258/treatment-of-osteochondral-defects-with-a-combination-of-bone-grafting-and-amic-technique
#5
Arnd Hoburg, Julia Marcella Leitsch, Gerd Diederichs, Rex Lehnigk, Carsten Perka, Roland Becker, Sven Scheffler
INTRODUCTION: Osteochondral defects of the knee may cause functional impairment of young and sportively active patients. Different surgical treatment options have been proposed using either one or two step procedures. The aim of the current study was to evaluate mid-term outcomes of combined bone grafting with autologous matrix-associated chondrogenesis (AMIC) for the treatment of large osteochondral defects. MATERIALS AND METHODS: 15 Patients with osteochondrosis dissecans of the medial femoral condyle grade III or IV according to ICRS classification were treated with a single step surgical procedure combining bone grafting and the AMIC procedure...
May 15, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29765024/diffusion-markers-of-dendritic-density-and-arborization-in-gray-matter-predict-differences-in-intelligence
#6
Erhan Genç, Christoph Fraenz, Caroline Schlüter, Patrick Friedrich, Rüdiger Hossiep, Manuel C Voelkle, Josef M Ling, Onur Güntürkün, Rex E Jung
Previous research has demonstrated that individuals with higher intelligence are more likely to have larger gray matter volume in brain areas predominantly located in parieto-frontal regions. These findings were usually interpreted to mean that individuals with more cortical brain volume possess more neurons and thus exhibit more computational capacity during reasoning. In addition, neuroimaging studies have shown that intelligent individuals, despite their larger brains, tend to exhibit lower rates of brain activity during reasoning...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29763462/the-annotation-of-repetitive-elements-in-the-genome-of-channel-catfish-ictalurus-punctatus
#7
Zihao Yuan, Tao Zhou, Lisui Bao, Shikai Liu, Huitong Shi, Yujia Yang, Dongya Gao, Rex Dunham, Geoff Waldbieser, Zhanjiang Liu
Channel catfish (Ictalurus punctatus) is a highly adaptive species and has been used as a research model for comparative immunology, physiology, and toxicology among ectothermic vertebrates. It is also economically important for aquaculture. As such, its reference genome was generated and annotated with protein coding genes. However, the repetitive elements in the catfish genome are less well understood. In this study, over 417.8 Megabase (MB) of repetitive elements were identified and characterized in the channel catfish genome...
2018: PloS One
https://www.readbyqxmd.com/read/29760055/chemokine-c-c-motif-ligand-33-is-a-key-regulator-of-teleost-fish-barbel-development
#8
Tao Zhou, Ning Li, Yulin Jin, Qifan Zeng, Wendy Prabowo, Yang Liu, Changxu Tian, Lisui Bao, Shikai Liu, Zihao Yuan, Qiang Fu, Sen Gao, Dongya Gao, Rex Dunham, Neil H Shubin, Zhanjiang Liu
Barbels are important sensory organs in teleosts, reptiles, and amphibians. The majority of ∼4,000 catfish species, such as the channel catfish ( Ictalurus punctatus ), possess abundant whisker-like barbels. However, barbel-less catfish, such as the bottlenose catfish ( Ageneiosus marmoratus ), do exist. Barbeled catfish and barbel-less catfish are ideal natural models for determination of the genomic basis for barbel development. In this work, we generated and annotated the genome sequences of the bottlenose catfish, conducted comparative and subtractive analyses using genome and transcriptome datasets, and identified differentially expressed genes during barbel regeneration...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29756168/transsplenic-splenoportography-and-portal-venous-interventions-in-pediatric-patients
#9
Eric J Monroe, Ethan J Speir, C Matthew Hawkins, Giri Shivaram, Kevin S H Koo, Anne E Gill
BACKGROUND: Data regarding transsplenic portal venous access for diagnostic imaging and endovascular intervention in children are limited, possibly due to concerns regarding high bleeding risks and resultant underutilization. OBJECTIVE: To investigate the safety and utility of transsplenic splenoportography and portal venous interventions in children. MATERIALS AND METHODS: A retrospective review was performed of all pediatric patients undergoing percutaneous transsplenic portal venous access and intervention at two large tertiary pediatric institutions between January 2012 and April 2017 was performed...
May 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29751537/-mcpip3-as-a-potential-metastasis-suppressor-gene-in-human-colorectal-cancer
#10
Fat-Moon Suk, Chi-Ching Chang, Ren-Jye Lin, Shyr-Yi Lin, Ya-Ting Chen, Yu-Chih Liang
Monocyte chemotactic protein induced protein 3 (MCPIP3) belongs to the Cys⁻Cys⁻Cys⁻His (CCCH)-zinc finger protein family and contains a highly conserved CCCH-zinc finger domain and a Nedd4-BP1 YacP nuclease (NYN) domain. Previous studies showed that MCPIP3 inhibits the expression of proinflammatory genes, such as vascular cell adhesion molecule ( VCAM )-1, in human endothelial cells, but the roles and functions of MCPIP3 in cancer cells are still unknown. In human colorectal cancer specimens, we found that the messenger RNA expression of MCPIP3 was significantly downregulated in cancer tissues compared to adjacent normal tissues (18/25; average fold change of 8...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750983/a-novel-submucosal-injection-solution-for-endoscopic-resection-of-large-colorectal-lesions-a-randomized-double-blind-trial
#11
Alessandro Repici, Michael Wallace, Prateek Sharma, Pradeep Bhandari, Gianluca Lollo, Roberta Maselli, Cesare Hassan, Douglas K Rex
BACKGROUND: SIC-8000 (Eleview) is a new FDA-approved solution for submucosal injection developed to provide long-lasting cushion to facilitate endoscopic resection maneuvers. Our aim was to compare the efficacy and safety of SIC-8000 with those of saline solution, when performing endoscopic mucosal resection (EMR) of large colorectal lesions. METHODS: In a randomized double-blind trial, patients undergoing EMR for ≥20 mm colorectal non-pedunculated lesions were randomized in a 1:1 ratio between SIC-8000 and saline solution as control solution in 5 tertiary centers...
May 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29747465/guiding-device-for-the-patellar-cut-in-total-knee-arthroplasty-design-and-validation
#12
Erica L Rex, Cinzia Gaudelli, Emmanuel M Illical, John Person, Karen C T Arlt, Barry Wylant, Carolyn Anglin
An incorrect cut of the patella (kneecap) during total knee arthroplasty, affects the thickness in different quadrants of the patella, leading to pain and poor function. Because of the disadvantages of existing devices, many surgeons choose to perform the cut freehand. Given this mistrust of existing devices, a quick, but accurate, method is needed that guides the cut, without constraining the surgeon. A novel device is described that allows the surgeon to mark a line at the desired cutting plane parallel to the front (anterior) surface using a cautery tool, remove the device, and then align the saw guide, reamer, or freehand saw with the marked line to cut the patella...
May 10, 2018: Bioengineering
https://www.readbyqxmd.com/read/29744218/machine-perfusion-of-thoracic-organs
#13
REVIEW
Dirk Van Raemdonck, Filip Rega, Steffen Rex, Arne Neyrinck
This article summarizes recent knowledge and clinical advances in machine perfusion (MP) of thoracic organs. MP of thoracic organs has gained much attention during the last decade. Clinical studies are investigating the role of MP to preserve, resuscitate, and assess heart and lungs prior to transplantation. Currently, MP of the cardiac allograft is essential in all type DCD heart transplantation while MP of the pulmonary allograft is mandatory in uncontrolled DCD lung transplantation. MP of thoracic organs also offers an exciting platform to further investigate downregulation of the innate and adaptive immunity prior to reperfusion of the allograft in recipients...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29738887/transcriptome-analysis-reveals-enrichment-of-genes-associated-with-auditory-system-in-swimbladder-of-channel-catfish
#14
Yujia Yang, Xiaozhu Wang, Yang Liu, Qiang Fu, Changxu Tian, Chenglong Wu, Huitong Shi, Zihao Yuan, Suxu Tan, Shikai Liu, Dongya Gao, Rex Dunham, Zhanjiang Liu
In aquatic organisms, hearing is an important sense for acoustic communications and detection of sound-emitting predators and prey. Channel catfish is a dominant aquaculture species in the United States. As channel catfish can hear sounds of relatively high frequency, it serves as a good model for study auditory mechanisms. In catfishes, Weberian ossicles connect the swimbladder to the inner ear to transfer the forced vibrations and improve hearing ability. In this study, we examined the transcriptional profiles of channel catfish swimbladder and other four tissues (gill, liver, skin, and intestine)...
April 30, 2018: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29737402/gwas-analysis-using-interspecific-backcross-progenies-reveals-superior-blue-catfish-alleles-responsible-for-strong-resistance-against-enteric-septicemia-of-catfish
#15
Suxu Tan, Tao Zhou, Wenwen Wang, Yulin Jin, Xiaozhu Wang, Xin Geng, Jian Luo, Zihao Yuan, Yujia Yang, Huitong Shi, Dongya Gao, Rex Dunham, Zhanjiang Liu
Infectious diseases pose significant threats to the catfish industry. Enteric septicemia of catfish (ESC) caused by Edwardsiella ictaluri is the most devastating disease for catfish aquaculture, causing huge economic losses annually. Channel catfish and blue catfish exhibit great contrast in resistance against ESC, with channel catfish being highly susceptible and blue catfish being highly resistant. As such, the interspecific backcross progenies provide an ideal system for the identification of quantitative trait locus (QTL)...
May 8, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29735707/flight-motor-networks-modulate-primary-olfactory-processing-in-the-moth-manduca-sexta
#16
Phillip D Chapman, Rex Burkland, Samual P Bradley, Benjamin Houot, Victoria Bullman, Andrew M Dacks, Kevin C Daly
Nervous systems must distinguish sensory signals derived from an animal's own movements (reafference) from environmentally derived sources (exafference). To accomplish this, motor networks producing reafference transmit motor information, via a corollary discharge circuit (CDC), to affected sensory networks, modulating sensory function during behavior. While CDCs have been described in most sensory modalities, none have been observed projecting to an olfactory pathway. In moths, two mesothoracic to deutocerebral histaminergic neurons (MDHns) project from flight sensorimotor centers in the mesothoracic neuromere to the antennal lobe (AL), where they provide the sole source of histamine (HA), but whether they represent a CDC is unknown...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29726296/folate-molecular-encapsulator-tethered-biocompatible-polymer-grafted-with-magnetic-nanoparticles-for-augmented-drug-delivery
#17
Sivaraj Ramasamy, Rex Jeya Rajkumar Sam David, Israel V M V Enoch
Magnetic ferrite nanoparticles (MNPs) coated with biocompatible polymers capable of drug loading and release are fascinating nanostructures for delivering anti-cancer drugs. Herein, we report the synthesis and characterization of a novel β-cyclodextrin-folate-tethered dextran polymer. Nickel-zinc ferrite nanoparticles are prepared and coated with the polymer to form a biocompatible hybrid magnetic nanocarrier. To establish the significance of folate unit of the polymer in anticancer activity, a similar derivatized polymer, i...
May 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29726124/community-asthma-management-of-emergency-department-patients-a-pilot-study-of-adherence-with-national-consensus-guidelines
#18
Nicholas D Ross, David McD Taylor, Ashleigh J Sellar, Hayley H Chen, Luke D Plant, Daniel McLean, Paul Berlingeri, Rex Gavan, Tracey J Weiland, Jonathan C Knott, Christine F McDonald
We aimed to determine whether the outpatient management of ED patients with asthma adheres to Australia's Asthma Consensus Guidelines. Adult patients, under treatment for asthma, were administered a validated questionnaire. Data on their outpatient management were collected and analysed descriptively. Of 51 patients, 14 smoked and 35 did not undergo regular GP review. Twenty-one patients had a good understanding of a written asthma action plan although only 15 owned one. Fourteen patients used no preventer medication...
May 3, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29723512/a-phase-iii-study-evaluating-the-efficacy-and-safety-of-remimazolam-cns-7056-compared-with-placebo-and-midazolam-in-patients-undergoing-colonoscopy
#19
Douglas K Rex, Raj Bhandari, Taddese Desta, Michael DeMicco, Cynthia Schaeffer, Kyle Etzkorn, Charles Barish, Ronald Pruitt, Brooks D Cash, Daniel Quirk, Felix Tiongco, Shelby Sullivan, David Bernstein
BACKGROUND: Remimazolam is an ultrashort-acting benzodiazepine. METHODS: We performed a randomized double-blind comparison of remimazolam to placebo for outpatient colonoscopy. This study design was a requirement of the U.S. Food and Drug Administration. An additional group was randomized to open-label midazolam administered according to its package insert instructions (randomization ratio for remimazolam:placebo:midazolam was 30:6:10). Study medications were administered under the supervision of the endoscopist, without any involvement of an anesthesia specialist...
April 30, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29722827/a-broadly-conserved-nerd-genetically-interacts-with-the-exocyst-to-affect-root-growth-and-cell-expansion
#20
Rex Cole, Valera Peremyslov, Savanah Van Why, Ibrahim Moussaoui, Ann Ketter, Renee Cool, Matthew Andres Moreno, Zuzana Vejlupkova, Valerian Dolja, John E Fowler
The exocyst, a conserved, octameric protein complex helps mediate secretion at the plasma membrane, facilitating specific developmental processes that include control of root meristem size, cell elongation, and tip growth. A genetic screen for second-site enhancers in Arabidopsis identified NEW ENHANCER of ROOT DWARFISM1 (NERD1) as an exocyst interactor. Mutations in nerd1 combined with weak exocyst mutations in SEC8 and EXO70A1 result in a synergistic reduction in root growth. Alone, nerd1 alleles modestly reduce primary root growth, both by shortening the root meristem and by reducing cell elongation, but also result in a slight increase in root hair length, bulging, and rupture...
May 2, 2018: Journal of Experimental Botany
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