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https://www.readbyqxmd.com/read/28539434/estrogens-in-male-physiology
#1
REVIEW
Paul S Cooke, Manjunatha K Nanjappa, CheMyong Ko, Gail S Prins, Rex A Hess
Estrogens have historically been associated with female reproduction, but work over the last two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) and G protein-coupled estrogen receptor (GPER) also regulate male reproductive and nonreproductive organs. 17β-Estradiol (E2) is measureable in blood of men and males of other species, but in rete testis fluids, E2 reaches concentrations normally found only in females and in some species nanomolar concentrations of estrone sulfate are found in semen...
July 1, 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28539065/cartoon-versus-traditional-self-study-handouts-for-medical-students-cartoon-randomized-controlled-trial
#2
Detajin Junhasavasdikul, Kanokporn Sukhato, Suthan Srisangkaew, Nawanan Theera-Ampornpunt, Thunyarat Anothaisintawee, Alan Dellow
OBJECTIVE: The objective of this study is to compare the effectiveness of a "cartoon-style" handout with a "traditional-style" handout in a self-study assignment for preclinical medical students. METHODS: Third-year medical students (n = 93) at the Faculty of Medicine Ramathibodi Hospital, Mahidol University, took a pre-learning assessment of their knowledge of intercostal chest drainage. They were then randomly allocated to receive either a "cartoon-style" or a "traditional-style" handout on the same topic...
May 24, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28529439/pubertal-timing-and-youth-internalizing-psychopathology-the-role-of-relational-aggression
#3
Hayley Pomerantz, Justin Parent, Rex Forehand, Nicole Lafko Breslend, Jeffrey P Winer
The current study examined relational aggression as a potential mechanism that explains the association between off-time pubertal development and internalizing problems in youth. Youth gender was also examined as a moderator for the association between these variables. It was hypothesized that early pubertal maturation would be associated with higher levels of relationally aggressive behavior which, in turn, would be associated with elevated levels of internalizing problems. Parents of 372 children between the ages of 8 and 17 were recruited through Amazon's Mechanical Turk...
February 2017: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/28528939/aga-white-paper-training-and-implementation-of-endoscopic-image-enhancement-technologies
#4
Neil Gupta, Joel V Brill, Marcia Canto, Daniel DeMarco, Brian M Fennerty, Loren Laine, David Lieberman, Charles Lightdale, Elizabeth Montgomery, Robert Odze, Douglas Rex, Prateek Sharma, Jeffrey L Tokar, Michael L Kochman
Endoscopic image-enhancement technologies provide opportunities to visualize normal and abnormal tissues within the gastrointestinal (GI) tract in a manner that complements conventional white light endoscopic imaging. The additional information that is obtained enables the endoscopist to better identify, delineate, and characterize lesions and can facilitate targeted biopsies or, in some cases, eliminate the need to send samples for histologic analysis. Some of these technologies have been available for more than a decade, but despite this fact, there is limited use of these technologies by endoscopists...
June 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28526821/influence-of-soil-moisture-on-codenitrification-fluxes-from-a-urea-affected-pasture-soil
#5
Timothy J Clough, Gary J Lanigan, Cecile A M de Klein, Md Sainur Samad, Sergio E Morales, David Rex, Lars R Bakken, Charlotte Johns, Leo M Condron, Jim Grant, Karl G Richards
Intensively managed agricultural pastures contribute to N2O and N2 fluxes resulting in detrimental environmental outcomes and poor N use efficiency, respectively. Besides nitrification, nitrifier-denitrification and heterotrophic denitrification, alternative pathways such as codenitrification also contribute to emissions under ruminant urine-affected soil. However, information on codenitrification is sparse. The objectives of this experiment were to assess the effects of soil moisture and soil inorganic-N dynamics on the relative contributions of codenitrification and denitrification (heterotrophic denitrification) to the N2O and N2 fluxes under a simulated ruminant urine event...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526120/a-new-species-of-gambierdiscus-dinophyceae-from-the-south-west-pacific-gambierdiscus-honu-sp-nov
#6
Lesley Rhodes, Kirsty F Smith, Arjun Verma, Belinda G Curley, D Tim Harwood, Sam Murray, Gurjeet S Kohli, Dorothy Solomona, Teina Rongo, Rex Munday, Shauna A Murray
Two isolates of a new tropical, epiphytic dinoflagellate species, Gambierdiscus honu sp. nov., were obtained from macroalgae sampled in Rarotonga, Cook Islands, and from North Meyer Island, Kermadec Islands. Gambierdiscus honu sp. nov. had the common Gambierdiscus Kofoidian plate formula: Po, 3', 6″, 6C?, 6 or 7S, 5‴, 1p and 2⁗. The characteristic morphological features of this species were its relatively small short dorsoventral length and width and the shape of individual plates, in particular the combination of the hatchet-shaped 2' and pentagonal 3' plates and the length to width ratio of the antapical 1p plate...
May 2017: Harmful Algae
https://www.readbyqxmd.com/read/28521024/pipeline-embolization-device-for-pericallosal-artery-aneurysms-a-retrospective-single-center-safety-and-efficacy-study
#7
Katyucia De Macedo Rodrigues, Anna Luisa Kühn, Takamitsu Tamura, Guilherme Dabus, Peter Kan, Miklos G Marosfoi, J Diego Lozano, Mary Perras, Christopher Brooks, Mary C Howk, Samuel Y Hou, David E Rex, Francesco Massari, Matthew J Gounis, Ajay K Wakhloo, Ajit S Puri
BACKGROUND: Pericallosal artery aneurysm treatment may be challenging using traditional endovascular techniques. OBJECTIVE: To demonstrate the feasibility, efficacy, and safety of endovascular treatment of pericallosal artery aneurysm using flow diverters. METHODS: We performed a retrospective review of our institutional database from July 2013 through July 2016 and identified 7 subjects with a pericallosal artery aneurysm treated with the Pipeline embolization device (ev3 Neurovascular, Medtronic, Dublin, Ireland) and at least 1 follow-up angiogram...
May 17, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28515439/the-biomechanics-behind-extreme-osteophagy-in-tyrannosaurus-rex
#8
Paul M Gignac, Gregory M Erickson
Most carnivorous mammals can pulverize skeletal elements by generating tooth pressures between occluding teeth that exceed cortical bone shear strength, thereby permitting access to marrow and phosphatic salts. Conversely, carnivorous reptiles have non-occluding dentitions that engender negligible bone damage during feeding. As a result, most reptilian predators can only consume bones in their entirety. Nevertheless, North American tyrannosaurids, including the giant (13 metres [m]) theropod dinosaur Tyrannosaurus rex stand out for habitually biting deeply into bones, pulverizing and digesting them...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28503361/a-review-of-the-key-considerations-in-mental-health-services-research-a-focus-on-low-income-children-and-families
#9
Deborah J Jones, Margaret Anton, Chloe Zachary, Sarah Pittman, Patrick Turner, Rex Forehand, Olga Khavjou
Children have been particularly vulnerable to the economic challenges of the past decade, with half (45 to 51%) of children under the age of 18 living in a low-income home and nearly 22% of those living in poverty. Low-income children are overrepresented in a range of statistics on psychosocial maladjustment issues, but their families are less likely than other socioeconomic groups to participate in mental health services and intervention research. Thus, this review asserts that substantive advances in mental health services and intervention research with low income families must move beyond a between-group, deficit-focused perspective to a more nuanced contemplation of how to: 1) Operationalize the "income" in low-income families; 2) Disentangle the interrelationship of low income, race, and ethnicity; and 3) Optimize recruitment, engagement and retention efforts via sensitivity to the culture of low-income status...
December 2016: Couple & Family Psychology
https://www.readbyqxmd.com/read/28495594/elevated-%C3%AE-s-ms-timescale-backbone-dynamics-in-the-transition-state-analog-form-of-arginine-kinase
#10
Omar Davulcu, Yu Peng, Rafael Brüschweiler, Jack J Skalicky, Michael S Chapman
Arginine kinase catalyzes reversible phosphoryl transfer between arginine and ATP. Crystal structures of arginine kinase in an open, substrate-free form and closed, transition state analog (TSA) complex indicate that the enzyme undergoes substantial domain and loop rearrangements required for substrate binding, catalysis, and product release. Nuclear magnetic resonance (NMR) has shown that substrate-free arginine kinase is rigid on the ps-ns timescale (average S(2)=0.84±0.08) yet quite dynamic on the µs-ms timescale (35 residues with Rex, 12%), and that movements of the N-terminal domain and the loop comprising residues I182-G209 are rate-limiting on catalysis...
May 8, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28493792/transthoracic-echocardiography-pitfalls-and-limitations-as-delineated-at-cardiac-ct-and-mr-imaging-erratum
#11
Sachin B Malik, Natalie Chen, Rex A Parker, Joe Y Hsu
No abstract text is available yet for this article.
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28481046/human-neural-stem-cell-biodistribution-and-predicted-tumor-coverage-by-a-diffusible-therapeutic-in-a-mouse-glioma-model
#12
Michael E Barish, Kelsey Herrmann, Yang Tang, Siranush Argalian Herculian, Marianne Metz, Soraya Aramburo, Revathiswari Tirughana, Margarita Gutova, Alexander Annala, Rex A Moats, Leanne Goldstein, Russell C Rockne, Jennifer Gutierrez, Christine E Brown, Lucy Ghoda, Karen S Aboody
Engineered neural stem cells (NSCs) intrinsically migrating to brain tumors offer a promising mechanism for local therapeutic delivery. However, difficulties in quantitative assessments of NSC migration and in estimates of tumor coverage by diffusible therapeutics have impeded development and refinement of NSC-based therapies. To address this need, we developed techniques by which conventional serial-sectioned formalin-fixed paraffin-embedded (FFPE) brains can be analyzed in their entirety across multiple test animals...
June 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28476398/a-wound-complication-after-percutaneous-achilles-tendon-lengthening-requiring-surgical-excision-a-case-report
#13
Tiffany K Hoh, Rex W Hung, John S Steinberg, Katherine M Raspovic
A percutaneous tendo-Achilles lengthening procedure corrects limited ankle joint equinus by decreasing the pull of the triceps surae complex. The standard technique using 3-incision hemisection described by Hoke is often used in patients with diabetes because of the minimal number of incisions and low risk of wound complications. We describe a patient who underwent percutaneous tendo-Achilles lengthening with a resultant open wound complication requiring staged surgical debridement.
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28475768/white-paper-developing-antimicrobial-drugs-for-resistant-pathogens-narrow-spectrum-indications-and-unmet-needs
#14
Helen W Boucher, Paul G Ambrose, H F Chambers, Richard H Ebright, Amanda Jezek, Barbara E Murray, Jason G Newland, Belinda Ostrowsky, John H Rex
Despite progress in antimicrobial drug development, a critical need persists for new, feasible pathways to develop antibacterial agents to treat people infected with drug-resistant bacteria. Infections due to resistant Gram-negative bacilli continue to cause unacceptable morbidity and mortality. Antibacterial agents have been traditionally studied in non-inferiority clinical trials that focus on one site of infection (eg, complicated urinary tract infections, intra-abdominal infections), yet these designs may not be optimal, and often are not feasible, for study of infections caused by drug-resistant bacteria...
May 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28474757/a-priori-patient-specific-collision-avoidance-in-radiotherapy-using-consumer-grade-depth-cameras
#15
Rex A Cardan, Richard A Popple, John Fiveash
PURPOSE: In this study, we demonstrate and evaluate a low cost, fast and accurate avoidance framework for radiotherapy treatments. Furthermore, we provide an implementation which is patient specific and can be implemented during the normal simulation process. METHODS: Four patients and a treatment unit were scanned with a set of consumer depth cameras to create a polygon mesh of each object. Using a fast polygon interference algorithm, the models were virtually collided to map out feasible treatment positions of the couch and gantry...
May 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28472524/i-tasser-mr-automated-molecular-replacement-for-distant-homology-proteins-using-iterative-fragment-assembly-and-progressive-sequence-truncation
#16
Yan Wang, Jouko Virtanen, Zhidong Xue, Yang Zhang
Molecular replacement (MR) is one of the most common techniques used for solving the phase problem in X-ray crystal diffraction. The success rate of MR however drops quickly when the sequence identity between query and templates is reduced, while the I-TASSER-MR server is designed to solve the phase problem for proteins that lack close homologous templates. Starting from a sequence, it first generates full-length models using I-TASSER by iterative structural fragment reassembly. A progressive sequence truncation procedure is then used for editing the models based on local variations of the structural assembly simulations...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28465384/therapeutic-communities-enter-the-world-of-evidence-based-practice
#17
EDITORIAL
Rex Haigh
This editorial provides the modern-day context for a long-established psychiatric treatment, democratic therapeutic communities. As this treatment is now such a small field in psychiatry, readers may not have enough background to be able to place the research in a suitable context. This includes the previous gap in experimental research, the difference between the modern model and the one used in the 20th century and the general field of personality disorder evidence.
May 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28459786/is-the-central-venous-pressure-an-obsolescent-model-or-a-valuable-puzzle-stone-in-haemodynamic-monitoring
#18
Benedikt H Siegler, Steffen Rex, Rolf Rossaint, Markus A Weigand
No abstract text is available yet for this article.
June 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28448740/sequencing-on-the-solid-5500xl-system-in-depth-characterization-of-the-gc-bias
#19
Simone Roeh, Peter Weber, Monika Rex-Haffner, Jan M Deussing, Elisabeth B Binder, Mira Jakovcevski
Different types of sequencing biases have been described and subsequently improved for a variety of sequencing systems, mostly focusing on the widely used Illumina systems. Similar studies are missing for the SOLiD 5500xl system, a sequencer which produced many data sets available to researchers today. Describing and understanding the bias is important to accurately interpret and integrate these published data in various ongoing research projects. We report a particularly strong GC bias for this sequencing system when analyzing a defined gDNA mix of five microbes with a wide range of different GC contents (20-72%) when comparing to the expected distribution and Illumina MiSeq data from the same DNA pool...
April 27, 2017: Nucleus
https://www.readbyqxmd.com/read/28444116/effectiveness-of-in-hospital-geriatric-co-management-a-systematic-review-and-meta-analysis
#20
Bastiaan Van Grootven, Johan Flamaing, Bernadette Dierckx de Casterlé, Christophe Dubois, Katleen Fagard, Marie-Christine Herregods, Miek Hornikx, Annouschka Laenen, Bart Meuris, Steffen Rex, Jos Tournoy, Koen Milisen, Mieke Deschodt
Background: geriatric consultation teams have failed to impact clinical outcomes prompting geriatric co-management programmes to emerge as a promising strategy to manage frail patients on non-geriatric wards. Objective: to conduct a systematic review of the effectiveness of in-hospital geriatric co-management. Data sources: MEDLINE, EMBASE, CINAHL and CENTRAL were searched from inception to 6 May 2016. Reference lists, trial registers and PubMed Central Citations were additionally searched...
April 24, 2017: Age and Ageing
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