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https://www.readbyqxmd.com/read/29236391/age-related-changes-phospholipids-of-sterlet-in-liver-and-dorsal-muscles
#1
R R Suleimanova, E A Hudz, D O Melnychuk, L H Kalachniuk
Study of phospholipids changes peculiarities in the liver and dorsal muscles of sterlet (Acipenser ruthenus Linnaeus) may be important to determine the etiology and pathogenesis of fatty liver. We established that the content of total phospholipids in tissues of the liver and dorsal muscles of three-year-old sterlet was less than for two-year-old fish by 15% and 20% (P ≤ 0.01), respectively. The amount of phosphatidylcholine (P ≤ 0.05), phosphatidylethanolamine, phosphatidylserine (P ≤ 0.01), phosphatidylinositol (P ≤ 0...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236390/serum-glycomarkers-of-endoplasmic-reticulum-and-lysosomal-endosomal-system-stress-in-human-healthy-aging-and-diseases
#2
I U Pismenetskaya, T D Butters
To verify the idea that extracellular free oligosaccharides might be able to reflect the functional status of the endoplasmic reticulum (ER) and lysosomal-endosomal system, HPLC-profiles of serum-derived free oligosaccharides (FOS) in human healthy aging, acute myeloproliferative neoplasms, and cardiovascular pathologies were compared with intracellular glycans. After plasma deproteinization and FOS purification the oligosaccharides were labelled with anthranilic acid, separated into the neutral and charged with QAE Sephadex (Q25-120) chromatography and analysed using high-performance liquid chromatography (HPLC)...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236388/inhibition-of-ire1-modifies-hypoxic-regulation-of-g6pd-gpi-tkt-taldo1-pgls-and-rpia-genes-expression-in-u87-glioma-cells
#3
O H Minchenko, I A Garmash, D O Minchenko, A Y Kuznetsova, O O Ratushna
We have studied the effect of hypoxia on the expression level of mRNA of the basic enzymes of pentose-phosphate cycle (G6PD, TKT, TALDO1, PGLS and RPIA) and glucose-6-phosphate isomerase (GPI) in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme 1). It was shown that hypoxia leads to up-regulation of the expression of GPI and PGLS genes and to down-regulation of TALDO1 and RPIA genes in control glioma cells. Changes for GPI gene were more significant than for other genes. At the same time, inhibition of IRE1 modified the effect of hypoxia on the expression of all studied genes...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236385/lipoxygenases-and-their-metabolites-in-formation-of-plant-stress-tolerance
#4
L M Babenko, M M Shcherbatiuk, T D Skaterna, I V Kosakivska
The review focuses on the analysis of new information concerning molecular enzymology of lipoxygenases – proteins involved in lipid peroxidation and found in animals and plants. Modern concept of structural features, catalytic characteristics and functions of lipoxygenase family enzymes as well as products of their catalytic activity in plants have been discussed and summarized. Issues of enzyme localization in plant cells and tissues, evolution and distribution of lipoxygenases, involvement in production of signaling substances involved in formation of adaptation response to abiotic and biotic stress factors and in regulation of lipoxygenase signal system activity are highlighted...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236361/new-metabolites-produced-by-cylindrocarpon-sp-sy-39-from-a-driftwood
#5
Takuma Suzuki, Seiya Yoshida, Takuya Koseki, Takako Aboshi, Tetsuya Murayama, Unang Supratman, Yoshihito Shiono
Four novel cylindropyrone A (1), 10'-hydroxyilicicolinic acid D (3), cylindrolactones A (4) and B (5), together with known dihydroinfectopyrone (2) were isolated from the culture of Cylindrocarpon sp. SY-39 from a driftwood. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compound 3 showed antimicrobial activity against Staphylococcus aureus with MIC value of 5.0 μg/ml. This article is protected by copyright. All rights reserved.
December 13, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29236354/how-comprehensive-are-research-studies-investigating-the-efficacy-of-technology-enhanced-learning-resources-in-anatomy-education-a-systematic-review
#6
REVIEW
Lauren Clunie, Neil P Morris, Viktoria C T Joynes, James D Pickering
Anatomy education is at the forefront of integrating innovative technologies into its curricula. However, despite this rise in technology numerous authors have commented on the shortfall in efficacy studies to assess the impact such technology-enhanced learning (TEL) resources have on learning. To assess the range of evaluation approaches to TEL across anatomy education, a systematic review was conducted using MEDLINE, the Educational Resources Information Centre (ERIC), Scopus, and Google Scholar, with a total of 3,345 articles retrieved...
December 13, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29236353/iccs-escca-consensus-guidelines-for-the-high-sensitivity-flow-cytometric-detection-of-paroxysmal-nocturnal-hemoglobinuria-pnh-part-2-assay-optimization-and-reagent-selection
#7
EDITORIAL
D Robert Sutherland, Andrea Illingworth, Iuri Marinov, Fernando Ortiz, John Andreasen, Dan Payne, Paul K Wallace, Michael Keeney
Since publication in 2010 of the International Clinical Cytometry Society (ICCS) Consensus Guidelines for detection of Paroxysmal nocturnal hemoglobinuria (PNH) by flow cytometery, a great deal of work has been performed to develop, optimize and validate a number of high-sensitivity assays to detect PNH phenotypes in both Red Blood Cells (RBCs) and White Blood Cells (WBCs, neutrophils and monocytes). This section (Part 2) of the updated ICCS PNH Consensus Guidelines will focus on specific instrument setup for these PNH assays, the identification and proper testing of appropriate antibody conjugates and combinations therof, and basic assay design...
December 13, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29236350/iccs-escca-consensus-guidelines-to-detect-gpi-deficient-cells-in-paroxysmal-nocturnal-hemoglobinuria-pnh-and-related-disorders-part-3-data-analysis-reporting-and-case-studies
#8
Andrea Illingworth, Iuri Marinov, D Robert Sutherland, Orianne Wagner Ballon, Luigi DelVecchio
Over the past several years, a diverse group of physicians and other laboratory scientists have developed various recommendations and guidelines regarding best practices for PNH testing. This manuscript is based on these previous recommendations as well as various other relevant publications of experts in the area of PNH testing. The goal is to provide flow cytometry laboratories with an updated consensus approach to analysis and reporting of PNH results and to address the most common analytical challenges for accurate reporting of this rare disease...
December 13, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29236343/relationship-between-reticular-pseudodrusen-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration
#9
Chi Yun Doreen Ho, Jia Jia Lek, Khin Zaw Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
IMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their etiology remains unknown. RPD have been associated with reduced choroidal thickness but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness (ChT) and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study PARTICIPANTS: Participants were recruited from Centre for Eye Research Australia...
December 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29236339/physical-activity-level-among-children-recovering-from-severe-acute-malnutrition
#10
Esther Babirekere-Iriso, Maren Johanne Heilskov Rytter, Hanifa Namusoke, Ezekiel Mupere, Kim F Michaelsen, Søren Brage, Ken D Stark, Lotte Lauritzen, André Briend, Henrik Friis, Daniel Faurholt-Jepsen
OBJECTIVE: To assess the level and predictors of physical activity at discharge among children recovering from severe acute malnutrition (SAM). METHODS: We conducted a prospective study among 69 children 6 - 59 months of age admitted with SAM for nutritional rehabilitation at Mulago National Referral Hospital, Uganda. Using hip-mounted tri-axial accelerometers, we measured physical activity expressed as counts per minute (cpm) during the last three days of hospital treatment...
December 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29236332/a-new-mechanism-for-%C3%AE-lactamases-class-d-enzymes-degrade-1%C3%AE-methyl-carbapenems-via-lactone-formation
#11
Christopher T Lohans, Emma van Groesen, Kiran Kumar, Catherine L Tooke, James Spencer, Robert S Paton, Jürgen Brem, Christopher Schofield
β-Lactamases threaten the clinical use of carbapenems, considered antibiotics of last resort. The classical mechanism of serine carbapenemase activity proceeds via hydrolysis of an acyl-enzyme intermediate. We show that class D β-lactamases also degrade clinically used 1β-methyl-substituted carbapenems via the unprecedented formation of a carbapenem-derived β-lactone. β-Lactone formation results from the nucleophilic attack of the carbapenem hydroxyethyl side chain onto the ester carbonyl of the acyl-enzyme intermediate...
December 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29236329/predicting-the-bioavailability-of-sediment-bound-uranium-to-the-freshwater-midge-chironomus-dilutus-using-physicochemical-properties
#12
Sarah E Crawford, Stephen Lofts, Karsten Liber
Assessment of uranium (U)-contaminated sediment is often hindered by the inability to accurately account for the physicochemical properties of sediment that modify U bioavailability. The goal of this research was to determine whether sediment-associated U bioavailability could be predicted over a wide range of conditions and sediment properties using simple regressions and a geochemical speciation model, the Windermere Humic Aqueous Model (WHAM7). Data from U-contaminated field sediment bioaccumulation tests, along with previously published bioaccumulation studies with U-spiked field and formulated sediments were used to examine the models...
December 13, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29236297/mri-change-metrics-of-facioscapulohumeral-muscular-dystrophy-stir-and-t1
#13
Mark R Ferguson, Sandra L Poliachik, Christopher B Budech, Nancy E Gove, Gregory T Carter, Leo H Wang, Daniel G Miller, Dennis W W Shaw, Seth D Friedman
INTRODUCTION: MRI evaluation in facioscapulohumeral muscular dystrophy (FSHD) demonstrates fatty replacement and inflammation/edema in muscle. Our previous work demonstrated Short T1 Inversion Recovery (STIR)-hyperintense (STIR+) signal in muscle 2 years prior to fatty replacement. We evaluated leg muscle STIR changes and fatty replacement within 14 months. METHODS: FSHD subjects received 2 MRI scans of thigh and calf over a 6.9-13.8 month interval. Quality of life measures were collected...
December 13, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29236290/an-eight-generation-family-with-cmtx-confirmation-of-the-pathogenicity-of-a-3-untranslated-region-mutation-in-gjb1-and-its-clinical-features
#14
Dong-Hui Chen, Maxwell Ma, Mena Scavina, Elizabeth Blue, John Wolff, Prasanthi Karna, Michael O Dorschner, Wendy H Raskind, Thomas D Bird
INTRODUCTION: Mutations in gap junction protein beta 1 (GJB1) on the X chromosome represent one of the most common causes of hereditary neuropathy. We assessed manifestations associated with a rare 3' untranslated region mutation (UTR) of GJB1 in a large family with X-linked Charcot-Marie-Tooth (CMTX). METHODS: Clinical, electrophysiological, and molecular genetic analyses of an eight-generation family with CMTX. RESULTS: There we 22 affected males and 19 symptomatic females, including an 83-year old woman followed for 40 years...
December 13, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29236272/medical-malpractice-and-transoral-robotic-surgery-evaluation-and-some-preemptive-thoughts
#15
Daniel D Lydiatt, Ryan Sewell
Medical malpractice is costly and disruptive, and it is important to prevent. We conducted a study with the objective to look at medical malpractice in robotic surgery overall, to evaluate reasons for litigation, and to comment on possible strategies to avoid litigation with transoral robotic surgery. We used the Westlaw computerized database to identify all state and federal verdict summaries in medical malpractice cases. We found 17 cases alleging malpractice that involved the use of robotic surgery. In all, the plaintiffs in 6 cases (35%) contended that an open rather than a robotic approach should have been used, 5 (29%) alleged negligent credentialing, 4 (24%) alleged training deficiencies, 2 (12%) alleged manufacturing problems, and 1 (6%) charged that robotic surgery should have been performed instead of open surgery (1 case involved two of these allegations)...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236258/using-tet-off-cells-and-rnai-knockdown-to-assay-mrna-decay
#16
Thomas D Baird, J Robert Hogg
Cellular mRNA levels are determined by the competing forces of transcription and decay. A wide array of cellular mRNA decay pathways carry out RNA turnover either on a constitutive basis or in response to changing cellular conditions. Here, we outline a method to investigate mRNA decay that employs RNAi knockdown of known or putative decay factors in commercially available Tet-off cell systems. Reporter mRNAs of interest are expressed under the control of a tetracycline-regulated promoter, allowing pulse-chase mRNA decay assays to be conducted...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29236238/internet-based-guided-self-help-for-glioma-patients-with-depressive-symptoms-a-randomized-controlled-trial
#17
Florien W Boele, Martin Klein, Irma M Verdonck-de Leeuw, Pim Cuijpers, Jan J Heimans, Tom J Snijders, Maaike Vos, Ingeborg Bosma, Cees C Tijssen, Jaap C Reijneveld
Depressive symptoms are common in glioma patients, and can negatively affect health-related quality of life (HRQOL). We performed a nation-wide randomized controlled trial to evaluate the effects of an online guided self-help intervention for depressive symptoms in adult glioma patients. Glioma patients with depressive symptoms were randomized to a 5-week online course based on problem-solving therapy, or a waiting list control group. After having received the intervention, the glioma patient groups combined were compared with patients with cancer outside the central nervous system (non-CNS cancer controls), who also received the intervention...
December 13, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29236237/outcome-of-children-and-adolescents-with-central-nervous-system-tumors-in-phase-i-trials
#18
Fernando Carceller, Francisco Bautista, Irene Jiménez, Raquel Hladun-Álvaro, Cécile Giraud, Luca Bergamaschi, Madhumita Dandapani, Isabelle Aerts, François Doz, Didier Frappaz, Michela Casanova, Bruce Morland, Darren R Hargrave, Gilles Vassal, Andrew D J Pearson, Birgit Geoerger, Lucas Moreno, Lynley V Marshall
Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the outcome of children and adolescents with CNS tumors participating in phase I trials within the Innovative Therapies for Children with Cancer (ITCC) consortium. Patients with solid tumors aged < 18 years at enrollment in their first dose-finding trial between 2000 and 2014 at eight ITCC centers were included retrospectively. Survival was evaluated using univariate/multivariate analyses...
December 13, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29236236/the-co-evolution-of-bullying-perpetration-homophobic-teasing-and-a-school-friendship-network
#19
Gabriel J Merrin, Kayla de la Haye, Dorothy L Espelage, Brett Ewing, Joan S Tucker, Matthew Hoover, Harold D Green
Bullying and homophobic teasing behaviors affect the lives of many school aged children, often co-occur, and tend to peak in middle school. While bullying and homophobic teasing behaviors are known to be peer group phenomena, studies typically examine the associations at the individual or school levels. An examination of these behaviors at the peer group level can aid in our understanding of the formation and maintenance of peer groups that engage in these forms of aggressive behavior (selection), and the extent to which friends and the peer group impact individual rates of these aggressive behaviors (influence)...
December 13, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29236234/assessment-of-the-functional-impact-of-germline-brca1-2-variants-located-in-non-coding-regions-in-families-with-breast-and-or-ovarian-cancer-predisposition
#20
E Santana Dos Santos, S M Caputo, L Castera, M Gendrot, A Briaux, M Breault, S Krieger, P K Rogan, E J Mucaki, L J Burke, I Bièche, C Houdayer, D Vaur, D Stoppa-Lyonnet, M A Brown, F Lallemand, E Rouleau
PURPOSE: The molecular mechanism of breast and/or ovarian cancer susceptibility remains unclear in the majority of patients. While germline mutations in the regulatory non-coding regions of BRCA1 and BRCA2 genes have been described, screening has generally been limited to coding regions. The aim of this study was to evaluate the contribution of BRCA1/2 non-coding variants. METHODS: Four BRCA1/2 non-coding regions were screened using high-resolution melting analysis/Sanger sequencing or next-generation sequencing on DNA extracted from index cases with breast and ovarian cancer predisposition (3926 for BRCA1 and 3910 for BRCA2)...
December 13, 2017: Breast Cancer Research and Treatment
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