Read by QxMD icon Read


Rainer Schandry, Daniela Lindauer, Matthias Mauz
Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 - 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking...
June 18, 2018: Planta Medica
Rosalind D Kaplan
No abstract text is available yet for this article.
June 19, 2018: Annals of Internal Medicine
Bradley V Watts, Linda Williams, Peter D Mills, Douglas E Paull, Jeffrey A Cully, Stuart C Gilman, Robin R Hemphill
OBJECTIVES: Developing a workforce skilled in improving the safety of medical care has often been cited as an important means to achieve safer care. Although some educational programs geared toward patient safety have been developed, few advanced training programs have been described in the literature. We describe the development of a patient safety fellowship program. METHODS: We describe the development and curriculum of an Interprofessional Fellowship in Patient Safety...
June 15, 2018: Journal of Patient Safety
Laura E Cowley, Sabine Maguire, Daniel M Farewell, Harriet D Quinn-Scoggins, Matthew O Flynn, Alison M Kemp
Clinicians face unique challenges when assessing suspected child abuse cases. The majority of the literature exploring diagnostic decision-making in this field is anecdotal or survey-based and there is a lack of studies exploring decision-making around suspected abusive head trauma (AHT). We aimed to determine factors influencing decision-making and multidisciplinary collaboration in suspected AHT cases, amongst 56 child protection professionals. Semi-structured interviews were conducted with clinicians (25), child protection social workers (10), legal practitioners (9, including 4 judges), police officers (8), and pathologists (4), purposively sampled across southwest United Kingdom...
June 15, 2018: Child Abuse & Neglect
Franziska Schirrmacher, Thomas Köhler, Jürgen Endres, Tobias Lindenberger, Lennart Husvogt, James G Fujimoto, Joachim Hornegger, Arnd Dörfler, Philip Hoelter, Andreas K Maier
This paper introduces an universal and structure-preserving regularization term, called quantile sparse image (QuaSI) prior. The prior is suitable for denoising images from various medical imaging modalities. We demonstrate its effectiveness on volumetric optical coherence tomography (OCT) and computed tomography (CT) data, which show different noise and image characteristics. OCT offers high-resolution scans of the human retina but is inherently impaired by speckle noise. CT on the other hand has a lower resolution and shows high-frequency noise...
June 6, 2018: Medical Image Analysis
Tae-Yong Jeong, Jana Asselman, Karel A C De Schamphelaere, Filip Van Nieuwerburgh, Dieter Deforce, Sang Don Kim
Propranolol (PRO), a human β-AR (β-adrenergic receptor) antagonist, is considered to result in specific effects in a non-target species, D. magna, based on our previous studies. The present study investigated the effects of β-AR agents, including an antagonist and agonist using pharmacologically relevant endpoints as well as a more holistic gene expression approach to reveal the impacts and potential mode of actions (MOAs) in the model non-target species. Results show that the responses in cardiac endpoints and gene expression in D...
June 12, 2018: Environmental Pollution
D Rochman, A Vasiliev, H Ferroukhi, M Pecchia
In this paper, a new method is proposed to systematically calculate at the same time canister loading curves and radiation sources, based on the inventory information from an in-core fuel management system. As a demonstration, the isotopic contents of the assemblies come from a Swiss PWR, considering more than 6000 cases from 34 reactor cycles. The CS2 M approach consists in combining four codes: CASMO and SIMULATE to extract the assembly characteristics (based on validated models), the SNF code for source emission and MCNP for criticality calculations for specific canister loadings...
June 15, 2018: Journal of Hazardous Materials
M Horne, R Emsley, A Woodham, A Wearden, D A Skelton
OBJECTIVE: High prevalence of sedentary behaviour is seen in most immigrant groups in Western countries, particularly in those from the Indian subcontinent. The primary objective of this study was to determine the sociocognitive associations with intention to undertake physical activity (PA) among separate groups of Indian, Pakistani and Bangladeshi older adults aged ≥60 years in the North West of England, UK. STUDY DESIGN: Cross-sectional survey METHODS: Using a cross-sectional survey, informed by the Theory of Planned Behaviour (TPB), 138 of 964 South Asian (SA) older adults completed a mailed questionnaire that assessed self-reported PA and TPB variables...
June 15, 2018: Public Health
Joaquin T Valderrama, Elizabeth Francis Beach, Ingrid Yeend, Mridula Sharma, Bram Van Dun, Harvey Dillon
Recent animal studies have shown that the synapses between inner hair cells and the dendrites of the spiral ganglion cells they innervate are the elements in the cochlea most vulnerable to excessive noise exposure. Particularly in rodents, several studies have concluded that exposure to high level octave-band noise for 2 h leads to an irreversible loss of around 50% of synaptic ribbons, leaving audiometric hearing thresholds unaltered. Cochlear synaptopathy following noise exposure is hypothesized to degrade the neural encoding of sounds at the subcortical level, which would help explain certain listening-in-noise difficulties reported by some subjects with otherwise 'normal' hearing...
June 12, 2018: Hearing Research
Xiu-Wen Wu, You-Bo Zhang, Lei Zhang, Xiu-Wei Yang
A method of ultra high performance liquid chromatography with tandem mass spectrometry was developed for the simultaneous quantification of 33 active components including 26 coumarins and 7 phenolic acid esters in Notopterygii Rhizoma et Radix (NRR). Chromatographic separation was achieved on a Kinetex® C18 column (100 mm × 2.1 mm i.d.; 2.6 μm) with a gradient elution in 18 min. Electrospray ionization tandem mass spectrometric detection was conducted in the positive and negative ionization modes with multiple reaction monitoring...
June 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Robert D Ashford, Austin M Brown, Brenda Curtis
BACKGROUND: The general public, treatment professionals, and healthcare professionals have been found to exhibit an explicit negative bias towards substance use and individuals with a substance use disorder (SUD). Terms such as "substance abuser" and "opioid addict" have shown to elicit greater negative explicit bias. However, other common terms have yet to be empirically studied. METHODS: 1,288 participants were recruited from ResearchMatch...
June 13, 2018: Drug and Alcohol Dependence
Lisa Bartha-Doering, Astrid Novak, Kathrin Kollndorfer, Gregor Kasprian, Anna-Lisa Schuler, Madison M Berl, Florian Ph S Fischmeister, William D Gaillard, Johanna Alexopoulos, Daniela Prayer, Rainer Seidl
This study considered the involvement of the mesial temporal lobe (MTL) in language and verbal memory functions in healthy children and adolescents. We investigated 30 healthy, right-handed children and adolescents, aged 7-16, with a fMRI language paradigm and a comprehensive cognitive test battery. We found significant MTL activations during language fMRI in all participants; 63% of them had left lateralized MTL activations, 20% exhibited right MTL lateralization, and 17% showed bilateral MTL involvement during the fMRI language paradigm...
June 15, 2018: Brain and Language
Jingjie Hu, Yuxiao Zhou, John D Obayemi, Jing Du, Winston O Soboyejo
An improved understanding of the evolution of cell structure and viscoelasticity with cancer malignancy could enable the development of a new generation of biomarkers and methods for cancer diagnosis. Hence, in this study, we present the viscoelastic properties (moduli and viscosities) and the actin cytoskeletal structures of triple negative breast cancer (TNBC) cells with different metastatic potential. These include: MCF-10A normal breast cells (studied as a control); MDA-MB-468 cells (less metastatic TNBC cells), and MDA-MB-231 cells (highly metastatic TNBC cells)...
May 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Bruna Medeiros-Neves, Helder Ferreira Teixeira, Gilsane Lino von Poser
ETHNOPHARMACOLOGICAL RELEVANCE: Species of the genus Pterocaulon (Asteraceae) are used in different parts of the world for mainly to treat skin and liver diseases, as well as disorders of the respiratory system, among others. AIM OF THE STUDY: This review aims to discuss the present state of the art concerning the ethnobotanical uses, secondary metabolites and biological effects of Pterocaulon species and their chemical components. MATERIALS AND METHODS: The available information on the genus Pterocaulon was gathered from scientific databases (Web of Science, Pubmed, ScienceDirect, Scopus, ChemSpider, SciFinder ACS Publications, Wiley Online Library)...
June 15, 2018: Journal of Ethnopharmacology
Angel Josabad Alonso-Castro, Juan Ramón Zapata-Morales, Victor Arana-Argáez, Julio Cesar Torres-Romero, Eyra Ramírez-Villanueva, Sabino Eduardo Pérez-Medina, Marco Antonio Ramírez-Morales, Mario Alberto Juárez-Méndez, Yessica Paola Infante-Barrios, Fidel Martínez-Gutiérrez, Candy Carranza-Álvarez, Mario Alberto Isiordia-Espinoza, Andrés Flores-Santos
Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects. The in vitro and in vivo toxicity of EPE was evaluated using the comet assay in human peripheral blood mononuclear cells (PBMC) and the acute toxicity test in mice, respectively...
June 15, 2018: Journal of Ethnopharmacology
Hao Xu, Na Tong, Shaobin Huang, Waseem Hayat, Saima Fazal, Jianjun Li, Shuang Li, Jinwu Yan, Yongqing Zhang
The autotrophic removal of sulphate and nitrate in bioelectrochemical reactors was investigated at different external voltages (0.2, 0.4, 0.6, 0.8 and 1.0 V) under anaerobic conditions. Sulphate and nitrate removal, nitrite accumulation, reduction trend of nitrate and sulphate and microbial community structure were explored. Results indicate the highest removal efficiencies of nitrate and sulphate at 43.3 ± 2.8 and 7.1 ± 0.2 mg·l-1 ·d-1 when the voltage is 0.6 V. Moreover, nitrite accumulation decreases with increased voltage from 0...
June 15, 2018: Bioresource Technology
Xuehui Wu, Huizeng Sun, Mingyuan Xue, Diming Wang, Le Luo Guan, Jianxin Liu
Milk yield (MY) and milk protein (MP) content are crucial milk performance traits of dairy cows that directly affect the dairy profits. This study first proposed milk protein yield (MPY) by considering MY and MP content together. Forty multiparous cows were selected from the 348 Holstein dairy cows, which fed the same diet under the same management condition, to investigate the serum metabolome profiles and to identify key metabolites associated with MPY. Among them, 20 cows with a higher MPY (MY > 34...
June 15, 2018: Journal of Proteomics
Himanshu R Lukka, Stephanie L Pugh, Deborah W Bruner, Jean-Paul Bahary, Colleen A F Lawton, Jason A Efstathiou, Rajat J Kudchadker, Lee E Ponsky, Samantha A Seaward, Ian S Dayes, Darindra D Gopaul, Jeff M Michalski, Guila Delouya, Irving D Kaplan, Eric M Horwitz, Mack Roach, Wayne H Pinover, David C Beyer, John O Amanie, Howard M Sandler, Lisa A Kachnic
BACKGROUND: There is considerable interest in very short (ultrahypofractionated) radiotherapy regimens to treat prostate cancer based on potential radiobiological advantages, patient convenience and resource allocation benefits. OBJECTIVE: To demonstrate that detectable changes in health related quality of life measured by the bowel and urinary domains of the Expanded Prostate Cancer Index Composite (EPIC-50) were not substantially worse than baseline. DESIGN, SETTING, AND PARTICIPANTS: XXXX is a non-blinded randomized phase II study of NCCN low risk prostate cancer where each arm is compared to a historical control...
June 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Maria Lisa Rossi, Gemma Rubbini, Marta Martini, Rita Canella, Riccardo Fesce
The role of glutamate in quantal release at the cytoneural junction was examined by measuring mEPSPs and afferent spikes at the posterior canal in the intact frog labyrinth. Release was enhanced by exogenous glutamate, or DL-TBOA, a blocker of glutamate reuptake. Conversely, drugs acting on ionotropic glutamate receptors did not affect release; the AMPA-R blocker CNQX decreased mEPSP size in a dose-dependent manner; the NMDA-R blocker D-AP5 at concentrations <200 µM did not affect mEPSP size, either in the presence or absence of Mg and glycine...
June 15, 2018: Neuroscience
Wei Xu, Hua He, Li Zheng, Jia-Wei Xu, Chu-Zhao Lei, Gui-Min Zhang, Rui-Hua Dang, Hui Niu, Xing-Lei Qi, Hong Chen, Yong-Zhen Huang
Polymorphic adenoma gene 1 (PLAG1) is a member of the pleomorphic adenoma gene family. PLAG family of proteins as a nuclear transcription factor mainly play a role in regulating a variety of important genes in the body. The aim of this study was to examine the association of the PLAG1 polymorphism with growth traits in 566 cattle. A novel 19-bp indel mutation was identified in the PLAG1 by sequencing pooled DNA samples (Pool-Seq) and agarose gel electrophoresis methods. The PCR products of PLAG1 exhibited 3 genotypes and 2 alleles: 142 bp (denoted as W) and 123 bp (denoted as D)...
June 15, 2018: Gene
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"