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https://www.readbyqxmd.com/read/29055287/efficacy-and-tolerability-of-high-dose-pelargonium-extract-in-patients-with-the-common-cold
#1
David S Riley, Viktor G Lizogub, Andrea Zimmermann, Petra Funk, Walter Lehmacher
Context • The common cold (CC) is usually caused by a viral infection. Antibiotics are often prescribed unnecessarily for it, although no evidence exists for any benefit in the CC. Effective alternatives are needed. Objective • The study intended to evaluate the efficacy of 7630, a proprietary extract of Pelargonium sidoides, the active ingredient in umckaloabo, compared with a placebo for the treatment of the CC. Design • This was a prospective, double-blind, parallel-group, placebo-controlled, phase 3 clinical trial (RCT), with an adaptive group-sequential design with 2 parts, both of which were 2-arm trials...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055277/structural-photophysical-and-theoretical-studies-of-imidazole-based-excited-state-intramolecular-proton-transfer-molecules
#2
Sivaraman Somasundaram, Eswaran Kamaraj, Su Jin Hwang, Sanghyuk Park
Imidazole-based excited state intramolecular proton transfer (ESIPT) blue fluorescent molecules, 2-(1-(4-chlorophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Cl) and 2-(1-(4-bromophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Br) were designed and synthesized by Debus-Radziszewski method through a one-pot multicomponent reaction in high yield. The synthesized compounds were fully characterized by (1)H NMR, (13)C NMR, FT-IR, FT-Raman, GC-Mass, and elemental analysis. The molecular structures in single crystal lattice were studied by X-ray crystallographic analysis...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055273/dehydroepiandrosterone-and-cortisol-dehydroepiandrosterone-ratios-in-dairy-cattle-with-postpartum-metritis
#3
Neele Hendrika Gundlach, Maren Feldmann, Yasmin Gundelach, Marcelo Araujo Gil, Ursula Siebert, Martina Hoedemaker, Marion Schmicke
Dehydroepiandrosterone (DHEA), a C19 steroid synthesized predominantly by the adrenal cortex, and its sulfated precursor (DHEAS) has antiglucocorticoid and immunoprotective properties. DHEA is important in modulating inflammatory responses; therefore, we hypothesized that DHEA concentrations might be altered in bovine postpartum metritis. DHEA, DHEAS, the cortisol/DHEA-ratio (C/D-ratio) and the DHEAS/DHEA ratio were determined in cows with and without clinical metritis subcategorized by the blood leukocyte numbers...
September 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29055272/engaging-psychiatrists-in-the-diagnosis-of-psychogenic-nonepileptic-seizures-what-can-they-contribute
#4
Massimiliano Beghi, Giuseppe Erba, Cesare Maria Cornaggia, Giorgia Giussani, Elisa Bianchi, Gianni Porro, Michela Russo, Ettore Beghi
PURPOSE: To investigate if psychiatrists could predict the diagnosis of psychogenic nonepileptic seizures (PNES) by reviewing videos of seizures of various types and to compare the accuracy and the criteria leading to the diagnosis used by psychiatrists with those used by epileptologists. METHODS: Four board-certified psychiatrists were asked to review 23 videos capturing representative events of 21 unselected consecutive patients admitted to an epilepsy center for long-term video-EEG monitoring...
October 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29055270/executive-functioning-concern-about-falling-and-quadriceps-strength-mediate-the-relationship-between-impaired-gait-adaptability-and-fall-risk-in-older-people
#5
Maria Joana D Caetano, Stephen R Lord, Matthew A Brodie, Daniel Schoene, Paulo H S Pelicioni, Daina L Sturnieks, Jasmine C Menant
BACKGROUND: Reduced ability to adapt gait, particularly under challenging conditions, may be an important reason why older adults have an increased risk of falling. This study aimed to identify cognitive, psychological and physical mediators of the relationship between impaired gait adaptability and fall risk in older adults. METHODS: Fifty healthy older adults (mean±SD: 74±7years) were categorised as high or low fall risk, based on past falls and their performance in the Physiological Profile Assessment...
October 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29055269/decision-making-measured-by-the-iowa-gambling-task-in-alcohol-use-disorder-and-gambling-disorder-a-systematic-review-and-meta-analysis
#6
REVIEW
Ildikó Kovács, Mara J Richman, Zoltán Janka, Aniko Maraz, Bálint Andó
BACKGROUND AND AIMS: Gambling disorder (GD) and alcohol use disorder (AD) have similar features, such as elevated impulsivity and decision-making deficits, which are directly linked to relapse and poor therapeutic outcomes. Our aim was to assess decision-making characteristics in GD and AD patients compared to healthy controls (HC) based on one of the most frequently used measures of decision-making: the Iowa Gambling Task (IGT). METHODS: In our systematic literature search of three databases, we identified 1198 empirical articles that mentioned decision-making deficits with the use of the IGT in patients diagnosed with either AD or GD...
October 12, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29055259/functional-impairment-in-adult-bipolar-disorder-with-adhd
#7
Imma Torres, Marina Garriga, Brisa Sole, Caterina M Bonnín, Montse Corrales, Esther Jiménez, Eva Sole, Josep A Ramos-Quiroga, Eduard Vieta, Jose M Goikolea, Anabel Martínez-Aran
BACKGROUND: It is well established that patients with either bipolar disorder (BD) or attention-deficit/hyperactivity disorder (ADHD) present functional impairment even when in remission. Nevertheless, research on functional impairment with adult patients with bipolar disorder comorbid to ADHD (BD+ADHD) is very scarce. The main objective of the current report was to evaluate the overall and specific domains of functioning, in patients with BD+ADHD compared to patients with pure bipolar disorder (pBD) and healthy controls (HCs)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055257/efficacy-of-adjunctive-brexpiprazole-on-the-core-symptoms-of-major-depressive-disorder-a-post-hoc-analysis-of-two-pooled-clinical-studies
#8
J Craig Nelson, Emmanuelle Weiller, Peter Zhang, Catherine Weiss, Mary Hobart
BACKGROUND: Patients with major depressive disorder (MDD) who do not adequately respond to antidepressant treatment (ADT) may benefit from adjunctive atypical antipsychotics; however, certain agents target specific symptoms of depression and not the full syndrome. The aim of this analysis was to examine the effects of brexpiprazole, adjunct to ADT, on the core symptoms of MDD, defined using Montgomery-Åsberg Depression Rating Scale (MADRS) items. METHODS: This was a post hoc analysis of data from two 6-week, randomized, double-blind studies of adjunctive brexpiprazole in patients with MDD and inadequate response to ADTs (n = 1056)...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055245/biomechanical-analysis-of-an-interference-screw-and-a-novel-twist-lock-screw-design-for-bone-graft-fixation
#9
S Asnis, J Mullen, P D Asnis, N Sgaglione, T LaPorta, D A Grande, N O Chahine
BACKGROUND: Malpositioning of an anterior cruciate ligament graft during reconstruction can occur during screw fixation. The purpose of this study is to compare the fixation biomechanics of a conventional interference screw with a novel Twist Lock Screw, a rectangular shaped locking screw that is designed to address limitations of graft positioning and tensioning. METHODS: Synthetic bone (10, 15, 20lb per cubic foot) were used simulating soft, moderate, and dense cancellous bone...
October 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29055232/adverse-events-occurring-on-mental-health-units
#10
Peter D Mills, Bradley V Watts, Brian Shiner, Robin R Hemphill
OBJECTIVE: While the study of suicide on mental health units has a long history, the study of patient safety more generally is relatively new. Our objective was to determine the type and relative frequency of adverse events occurring on Veterans Health Administration (VHA) mental health units; the primary root causes for these events; and make recommendations for abating or mitigating these events. METHODS: We searched our national database for any reported adverse event that occurred on an inpatient mental health unit between January 1, 2015 and December 31, 2016...
September 9, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29055213/degradation-of-orange-g-by-fenton-like-reaction-with-fe-impregnated-biochar-catalyst
#11
Jong-Hwan Park, Jim J Wang, Ran Xiao, Negar Tafti, Ronald D DeLaune, Dong-Cheol Seo
This study was conducted to evaluate the catalytic activity of Fe-impregnated sugarcane biochar (FSB) for removing azo dye Orange G (OG) from solution under various Fenton-like oxidation conditions. The optimum molar Fe concentration for impregnation to achieve maximum catalytic activity of FSB in Fenton-like reaction with acceptable effluent Fe release was 0.25 M (163.4 Fe mg/g in FSB). High removal efficiency of 99.7% was achieved within 2 h of reaction at optimum conditions of 0.075 g/L H2O2, 0...
October 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29055202/tio2-nanoparticles-in-seawater-aggregation-and-interactions-with-the-green-alga-dunaliella-tertiolecta
#12
Elisabetta Morelli, Edi Gabellieri, Alessandra Bonomini, Danika Tognotti, Giacomo Grassi, Ilaria Corsi
Titanium dioxide nanoparticles (TiO2 NPs) have been widely employed in industrial applications, thus rising concern about their impact in the aquatic environment. In this study we investigated the chemical behaviour of TiO2 NPs in the culture medium and its effect on the green alga Dunaliella tertiolecta, in terms of growth inhibition, oxidative stress, ROS (Reactive Oxygen Species) accumulation and chlorophyll content. In addition, the influence of exopolymeric substances (EPS) excreted by the microalgae on the stability of NPs has been evaluated...
October 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29055196/urinary-p-cresol-diagnosis-using-nanocomposite-of-zno-mos2-and-molecular-imprinted-polymer-on-optical-fiber-based-lossy-mode-resonance-sensor
#13
Sruthi P Usha, Banshi D Gupta
A lossy mode resonance (LMR) based sensor for urinary p-cresol testing on optical fiber substrate is developed. The sensor probe fabrication includes dip coating of nanocomposite layer of zinc oxide and molybdenum sulphide (ZnO/MoS2) over unclad core of optical fiber as the transducer layer followed by the layer of molecular imprinted polymer (MIP) as the recognition medium. The addition of molybdenum sulphide in the transducer layer increases the absorption of light in the medium which enhances the LMR properties of zinc oxide thereby increasing the conductivity and hence the sensitivity of the sensor...
October 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29055186/designed-inhibitors-with-hetero-linkers-for-gastric-proton-pump-h-k-atpase-steered-molecular-dynamics-and-metadynamics-studies
#14
Kalyanashis Jana, Tusar Bandyopadhyay, Bishwajit Ganguly
Acid suppressant SCH28080 and its derivatives reversibly reduce acid secretion activity of the H(+),K(+)-ATPase in a K(+) competitive manner. The results on homologation of the SCH28080 by varying the linker chain length suggested the improvement in efficacy. However, the pharmacokinetic studies reveal that the hydrophobic nature of the CH2 linker units may not help it to function as a better acid suppressant. We have exploited the role of linker unit to enhance the efficacy of such reversible acid suppressant drug molecules using hetero linker, i...
October 12, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29055178/n-acetylborrelidin-b-a-new-bioactive-metabolite-from-streptomyces-mutabilis-sp-mii
#15
Abdelaaty Hamed, Ahmed S Abdel-Razek, Marcel Frese, Daniel Wibberg, Atef F El-Haddad, Tarek M A Ibrahim, Jörn Kalinowski, Norbert Sewald, Mohamed Shaaban
In the course of our screening program for new bioactive compounds, a naturally new 18-membered macrolide antibiotic, N-acetylborrelidin B (1) along with borrelidin (2) were obtained from the marine Streptomyces mutabilis sp. MII. The strain was isolated from a sediment sample collected in the Red Sea at the Hurghada Coast and characterized taxonomically. Additional nine diverse bioactive compounds were reported: 6-prenyl-indole-3-acetonitrile (3), sitosteryl-3β-d-glucoside, campesterol, ferulic acid, linoleic acid methyl ester, linoleic acid, N-acetylanthranilic acid, indole 3-acetic acid methyl ester, indole 3-carboxylic acid, and adenosine...
October 21, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29055159/genomics-of-natural-populations-evolutionary-forces-that-establish-and-maintain-gene-arrangements-in-drosophila-pseudoobscura
#16
Zachary L Fuller, Gwilym D Haynes, Stephen Richards, Stephen W Schaeffer
The evolution of complex traits in heterogeneous environments may shape the order of genes within chromosomes. Drosophila pseudoobscura has a rich gene arrangement polymorphism that allows one to test evolutionary genetic hypotheses about how chromosomal inversions are established in populations. D. pseudoobscura has >30 gene arrangements on a single chromosome that were generated through a series of overlapping inversion mutations with > 10 inversions with appreciable frequencies and wide geographic distributions...
October 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29055155/apremilast-for-the-treatment-of-moderate-to-severe-palmoplantar-psoriasis-results-from-a-double-blind-placebo-controlled-randomized-study
#17
R Bissonnette, R Haydey, L Rosoph, C W Lynde, M Bukhalo, J Fowler, I Delorme, A Gagné-Henley, M Gooderham, Y Poulin, K Barber, P Jenkin, I Landells, D Pariser
BACKGROUND: Palmoplantar psoriasis is a variant of psoriasis vulgaris which can severely impair quality of life. OBJECTIVES: The main objectives of this double-blind, placebo-controlled, randomized study were to assess the efficacy and impact on quality of life and work productivity of apremilast for the treatment of moderate to severe palmoplantar psoriasis. METHODS: A total of 100 patients with moderate to severe palmoplantar psoriasis were randomized to either apremilast 30mg bid or placebo for 16 weeks...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055149/the-implementation-of-knowledge-dissemination-in-the-prevention-of-occupational-skin-diseases
#18
A Wilke, U Bollmann, S Cazzaniga, A Hübner, S M John, J Karadzinska-Bislimovska, D Mijakoski, D Šimić, D Simon, F Sonsmann, S Stoleski, P Weinert, B Wulfhorst
BACKGROUND: Occupational skin diseases (OSD) have a high medical, social, economic and political impact. Knowledge dissemination from research activities to key stakeholders involved in health care is a prerequisite to make prevention effective. OBJECTIVES: To study and prioritize different activity fields and stakeholders that are involved in the prevention of OSD, to reflect on their inter-relationships, to develop a strategic approach for knowledge dissemination and to develop a hands-on tool for OSD prevention projects METHODS: Seven different activity fields that are relevant in the prevention of OSD have been stepwise identified...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055142/the-fate-of-the-bone-graft-in-cerebrospinal-fluid-rhinorrhea-endoscopic-repair-for-idiopathic-intracranial-hypertension-a-retrospective-case-series-analysis
#19
A D Workman, R M Carey, A K Parasher, E C Kuan, J Godovchik, J T Glicksman, D W Kennedy, J N Palmer, N D Adappa
INTRODUCTION: Idiopathic intracranial hypertension (IIH) is a common cause of spontaneous cerebrospinal fluid (CSF) leaks necessitating surgical intervention, and grafting of septal, mastoid, or turbinate bone over the defect is increasingly performed to strengthen the repair of the primary defect. However, the postoperative fate of these grafted bone fragments is largely unknown. METHODOLOGY: We performed a retrospective study of patients at the University of Pennsylvania undergoing repair of spontaneous CSF leaks secondary to IIH...
October 21, 2017: Rhinology
https://www.readbyqxmd.com/read/29055134/geographic-patterns-and-pollination-ecotypes-in-claytonia-virginica
#20
Alison J Parker, Neal M Williams, James D Thomson
Geographical variation in pollinators visiting a plant can produce plant populations adapted to local pollinator environments. We documented two markedly different pollinator climates for the spring ephemeral wildflower Claytonia virginica: in more northern populations, the pollen-specialist bee Andrena erigeniae dominated, but in more southern populations, A. erigeniae visited rarely and the bee-fly Bombylius major dominated. Plants in the northern populations experience faster pollen depletion than plants in southern populations...
October 21, 2017: Evolution; International Journal of Organic Evolution
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