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https://www.readbyqxmd.com/read/27909086/the-12-item-psoriatic-arthritis-impact-of-disease-questionnaire-construct-validity-reliability-and-interpretability-in-a-clinical-setting
#1
Marco Di Carlo, Andrea Becciolini, Valentina Lato, Chiara Crotti, Ennio Giulio Favalli, Fausto Salaffi
OBJECTIVE: To study, in a real-life setting, the construct validity, the reliability, and the interpretability of the 12-item Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire in patients with psoriatic arthritis (PsA). METHODS: In 144 consecutive patients with PsA (81 men and 63 women, mean age of 51.4 ± 12.8 yrs, and 77 receiving biologic treatment), the PsAID-12 and other patient-reported outcomes (PRO) were collected, such as the Dermatology Life Quality Index...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27909084/sustained-benefits-of-exercise-based-motivational-interviewing-but-only-among-nonusers-of-opioids-in-patients-with-fibromyalgia
#2
Sunghye Kim, James E Slaven, Dennis C Ang
OBJECTIVE: Given the known side effects of opioids and their potential effects on cognition, we sought to evaluate the benefits of motivational interviewing (MI) to promote physical activity on 2 subsets of participants with fibromyalgia (FM): nonusers and users of opioids. METHODS: This was a secondary data analysis of a 36-week randomized controlled trial to assess the efficacy of MI to promote physical activity among participants with FM. Participants were randomized to 1 of 2 treatment arms: 6 phone-based MI sessions (n = 107) or 6 sessions of FM self-management instructions [attention control (AC), n = 109]...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27908545/association-between-fat-mass-and-bone-mineral-density-among-brazilian-women-differs-by-menopausal-status-the-pr%C3%A3-sa%C3%A3%C2%BAde-study
#3
Amina Chain, Marise Crivelli, Eduardo Faerstein, Flávia F Bezerra
OBJECTIVE: The aim of this study was to investigate the association between bone mineral density (BMD) and fat mass (FM) in a multiethnic population of Brazilian women and to evaluate the influence of total body mass and lean mass on this association. METHODS: This was a cross-sectional study nested within the Pro-Saúde Study, a prospective cohort of university civil servants in Rio de Janeiro. Participants were pre- (n = 100) and postmenopausal (n = 166) women...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27907206/intestinal-fluid-permeability-in-atlantic-salmon-salmo-salar-l-is-affected-by-dietary-protein-source
#4
Haibin Hu, Trond M Kortner, Karina Gajardo, Elvis Chikwati, John Tinsley, Åshild Krogdahl
In Atlantic salmon (Salmo salar L.), and also in other fish species, certain plant protein ingredients can increase fecal water content creating a diarrhea-like condition which may impair gut function and reduce fish growth. The present study aimed to strengthen understanding of the underlying mechanisms by observing effects of various alternative plant protein sources when replacing fish meal on expression of genes encoding proteins playing key roles in regulation of water transport across the mucosa of the distal intestine (DI)...
2016: PloS One
https://www.readbyqxmd.com/read/27906395/regioselective-plasmonic-nano-assemblies-for-bimodal-sub-femtomolar-dopamine-detection
#5
Fengli Gao, Liqiang Liu, Gang Cui, Liguang Xu, Xiaoling Wu, Hua Kuang, Chuanlai Xu
Reliable and ultrasensitive quantification of dopamine (DA) is essential in the precise diagnotherapy of neurological diseases. In this study, dual mode counterpropagating-responsive gold@silver nanoparticle-gold nanorod (Au@AgNP-AuNR) nano-assemblies were fabricated for the precise quantification of DA. The plasmonic Au@AgNP-AuNR assemblies possessed high surface-enhanced Raman scattering (SERS) activity and strong fluorescence quenching, due to the prominent electromagnetic enhancement between the hotspots of the assemblies...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906289/mesoporous-nanospheres-functionalized-optical-microfiber-biosensor-for-low-concentration-neurotransmitter-detection
#6
Mingfei Ding, Yunyun Huang, Tuan Guo, Li-Peng Sun, Bai-Ou Guan
A label-free and ultrasensitive microfiber interferometer biosensor has been demonstrated for detection of neurotransmitter molecule (5-HT). The surface morphology of the silicon dioxide nanospheres acting as molecule sieve provides an effective mean of gathering 5-HT molecules by designed mesoporous structure. The slight concentration change of 5-HT molecules is translated into a dramatic wavelength shift of the interferometric fringe pattern. The experimental results show that the biosensor has a linear response in concentration range from 100 fM to 1 µM and a detection limit as low as 84 fM...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906166/which-brca-genetic-testing-programs-are-ready-for-implementation-in-health-care-a-systematic-review-of-economic-evaluations
#7
Elvira D'Andrea, Carolina Marzuillo, Corrado De Vito, Marco Di Marco, Erica Pitini, Maria Rosaria Vacchio, Paolo Villari
PURPOSE: There is considerable evidence regarding the efficacy and effectiveness of BRCA genetic testing programs, but whether they represent good use of financial resources is not clear. Therefore, we aimed to identify the main health-care programs for BRCA testing and to evaluate their cost-effectiveness. METHODS: We performed a systematic review of full economic evaluations of health-care programs involving BRCA testing. RESULTS: Nine economic evaluations were included, and four main categories of BRCA testing programs were identified: (i) population-based genetic screening of individuals without cancer, either comprehensive or targeted based on ancestry; (ii) family history (FH)-based genetic screening, i...
December 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27902529/perceived-exertion-during-exercise-is-associated-with-children-s-energy-intake
#8
S Nicole Fearnbach, Travis D Masterson, Haley A Schlechter, Eric Loken, Danielle S Downs, David Thivel, Kathleen L Keller
PURPOSE: To examine the individual-level factors that predict energy intake (EI) following imposed exercise (EX) and sedentary time (SED) in children. METHODS: Healthy-weight children ages 9-12 years (n = 20) reported to the laboratory for 1 baseline and 2 experimental visits (EX and SED) each separated by 1 week in a randomized crossover design. Percent body fat, weight (kg), and height (m) were used to calculate fat-mass index (FM index) and fat-free mass index (FFM index; kg/m)...
November 29, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27902340/viral-bacterial-interactions-in-the-respiratory-tract
#9
Carla Bellinghausen, Gernot Gu Rohde, Paul Hm Savelkoul, Emiel Fm Wouters, Frank Rm Stassen
In the respiratory tract, viruses and bacteria can interact on multiple levels. It is well known that respiratory viruses, particularly influenza viruses, increase the susceptibility to secondary bacterial infections. Numerous mechanisms, including compromised physical and immunological barriers, and changes in the microenvironment have hereby been shown to contribute to the development of secondary bacterial infections. In contrast, our understanding of how bacteria shape a response to subsequent viral infection is still limited...
October 18, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901249/depression-sexuality-and-fibromyalgia-syndrome-clinical-findings-and-correlation-to-hematological-parameters
#10
Bruna Alves, Telma M Zakka, Manoel J Teixeira, Helena H Kaziyama, Jose T T Siqueira, Silvia R D T Siqueira
Objective: To investigate sexuality and depression in women with FM compared with controls and to correlate the findings with hematological parameters. Methods: 33 women with FM and 19 healthy women were included and evaluated with the following instruments: Female Sexual Function Index, Beck Inventory, Visual Analogue Scale, medical history and laboratory exams. Results: The prevalence of sexual dysfunction (P = 0.007) and depression (P < 0...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27898936/nutrient-transporters-in-bovine-uteroplacental-tissues-on-days-sixteen-to-fifty-of-gestation
#11
M S Crouse, K J McLean, M R Crosswhite, L P Reynolds, C R Dahlen, B W Neville, P P Borowicz, J S Caton
During early gestation, nutrients are transported to the developing embryo via transporters in the uterine endometrium and chorioallantois. In the present study, we examined glucose transporters and and the cationic AA transporters , , and to test the hypotheses that 1) relative mRNA expression of transporters would be different among uteroplacental tissue type as gestation progresses and 2) concentrations of glucose and cationic AA would be different among target sites (placental compartments, serum, and histotrophic) and days of gestation...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898909/protein-and-amino-acid-bioavailability-of-extruded-dog-food-with-protein-meals-of-different-quality-using-growing-mink-as-a-model
#12
M T Tjernsbekk, A-H Tauson, C F Matthiesen, Ø Ahlstrøm
The present study evaluated growing mink () as a model for dietary protein quality assessment of protein meals used in extruded dog foods. Three foods with similar CP content but of different protein quality were produced using different protein meals. The protein meals varied with respect to CP digestibility and AA composition and included lamb meal (LBM), poultry meal (PM), and fish meal (FM) with low, intermediate, and high protein quality, respectively. Nitrogen balance, BW gain, protein efficiency ratio (PER), and apparent total tract digestibility (ATTD) were used as measures of protein and AA bioavailability in growing mink...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898863/rapid-communication-expression-of-an-endogenous-retroviral-element-during-early-gestation-in-beef-heifers
#13
K J McLean, M S Crouse, M R Crosswhite, D N Black, C R Dahlen, P P Borowicz, L P Reynolds, A K Ward, B W Neville, J S Caton
Endogenous retroviral gene elements have been implicated in development and formation of the feto-maternal interface. A variant of the syncytin endogenous retroviral envelope gene family, , was recently found in ruminants. We hypothesized that mRNA would be differentially expressed in utero-placental tissues and would fluctuate during key time points of early gestation in beef heifers. Commercial Angus crossbred heifers ( = 46; ∼15 mo of age; BW = 362.3 ± 34.7kg) housed in 6-animal pens were fed daily with native grass hay and supplemented with cracked corn to gain 0...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898848/rapid-communication-isolation-of-glucose-transporters-and-in-bovine-uteroplacental-tissues-from-days-16-to-50-of-gestation
#14
M S Crouse, J S Caton, K J McLean, P P Borowicz, L P Reynolds, C R Dahlen, B W Neville, A K Ward
Glucose transporter solute carrier family 2 member 14 () is a duplicon of glucose transporter solute carrier family 2 member 3 () with a 95% shared homology to and has not previously been isolated in ruminant uteroplacental tissues. The transporter has been previously isolated in Holstein heifer uterine epithelium but not in ovine epithelium. We hypothesized that and its duplicon would be found in bovine uteroplacental tissues and that maternal nutrition and day of gestation would impact mRNA expression of and ...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898676/dietary-butyrate-helps-to-restore-the-intestinal-status-of-a-marine-teleost-sparus-aurata-fed-extreme-diets-low-in-fish-meal-and-fish-oil
#15
Itziar Estensoro, Gabriel Ballester-Lozano, Laura Benedito-Palos, Fabian Grammes, Juan Antonio Martos-Sitcha, Liv-Torunn Mydland, Josep Alvar Calduch-Giner, Juan Fuentes, Vasileios Karalazos, Álvaro Ortiz, Margareth Øverland, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánchez
There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period...
2016: PloS One
https://www.readbyqxmd.com/read/27897251/co-thin-films-deposited-directly-on-zno-polar-surfaces
#16
Daichi Chiba, Naoya Shibata, Atsushi Tsukazaki
A ferromagnetic (FM)-metal/oxide stack is the key structure determining the performance of spintronic devices. However, the effect of the electronic polarity of the oxide on the magnetic properties of the adjacent FM-metal has not been investigated previously. Here, we report the magnetic and structural properties of Co ultra-thin films sputter deposited directly on the Zn- and O-polar surfaces of ZnO substrates. The magnetic anisotropy and Curie temperature exhibit dramatic polarity-dependent differences for films on these surfaces...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896487/natural-compounds-as-occult-ototoxins-ginkgo-biloba-flavonoids-moderately-damage-lateral-line-hair-cells
#17
Sarah Neveux, Nicole K Smith, Anna Roche, Bruce E Blough, Wimal Pathmasiri, Allison B Coffin
Several drugs, including aminoglycosides and platinum-based chemotherapy agents, are well known for their ototoxic properties. However, FDA-approved drugs are not routinely tested for ototoxicity, so their potential to affect hearing often goes unrecognized. This issue is further compounded for natural products, where there is a lack of FDA oversight and the manufacturer is solely responsible for ensuring the safety of their products. Natural products such as herbal supplements are easily accessible and commonly used in the practice of traditional eastern and alternative medicine...
November 28, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27895598/pharmacotherapy-for-alcohol-use-disorders-physicians-perceptions-and-practices
#18
Caridad Ponce Martinez, Priyanka Vakkalanka, Nassima Ait-Daoud
BACKGROUND AND OBJECTIVES: Alcohol use disorders (AUDs) are an important cause of morbidity and mortality. Despite the National Institute on Alcohol Abuse and Alcoholism (NIAAA) recommendations that medications be considered for patients with alcohol dependence, the mainstay of treatment has been counseling. We designed a survey to assess the treatment practices of psychiatrists and family medicine (FM) physicians in an effort to identify barriers to the use of pharmacotherapy and develop strategies to increase physician knowledge and utilization of these medications...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27895505/evaluating-increased-resource-use-in-fibromyalgia-using-electronic-health-records
#19
Jay M Margolis, Elizabeth T Masters, Joseph C Cappelleri, David M Smith, Steven Faulkner
OBJECTIVE: The management of fibromyalgia (FM), a chronic musculoskeletal disease, remains challenging, and patients with FM are often characterized by high health care resource utilization. This study sought to explore potential drivers of all-cause health care resource utilization and other factors associated with high resource use, using a large electronic health records (EHR) database to explore data from patients diagnosed with FM. METHODS: This was a retrospective analysis of de-identified EHR data from the Humedica database...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27891134/cucumber-cucumis-sativus-l-nitric-oxide-synthase-associated-gene1-csnoa1-plays-a-role-in-chilling-stress
#20
Xingwang Liu, Bin Liu, Shudan Xue, Yanlinq Cai, Wenzhu Qi, Chen Jian, Shuo Xu, Ting Wang, Huazhong Ren
Nitric oxide (NO) is a gaseous signaling molecule in plants, transducing information as a result of exposure to low temperatures. However, the underlying molecular mechanism linking NO with chilling stress is not well understood. Here, we functionally characterized the cucumber (Cucumis sativus L.) nitric oxide synthase-associated gene, NITRIC OXIDE ASSOCIATED 1 (CsNOA1). Expression analysis of CsNOA1, using quantitative real-time PCR, in situ hybridization, and a promoter::β-glucuronidase (GUS) reporter assay, revealed that it is expressed mainly in the root and shoot apical meristem (SAM), and that expression is up-regulated by low temperatures...
2016: Frontiers in Plant Science
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