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https://www.readbyqxmd.com/read/28720918/perceived-motivating-factors-and-barriers-for-the-completion-of-postgraduate-training-among-american-pharmacy-students-prior-to-beginning-advanced-pharmacy-practice-experiences
#1
Drayton A Hammond, Douglas R Oyler, John W Devlin, Jacob T Painter, Scott Bolesta, Joseph M Swanson, Brett J Bailey, Trisha Branan, Jeffrey F Barletta, Brianne Dunn, Jason S Haney, Paul Juang, Sandra L Kane-Gill, Tyree H Kiser, Hira Shafeeq, Debra Skaar, Pamela Smithburger, Jodi Taylor
Objective. To examine perceived motivating factors and barriers (MFB) to postgraduate training (PGT) pursuit among pharmacy students. Methods. Third-year pharmacy students at 13 schools of pharmacy provided demographics and their plan and perceived MFBs for pursuing PGT. Responses were characterized using descriptive statistics. Kruskal-Wallis equality-of-proportions rank tests determined if differences in perceived MFBs existed between students based on plan to pursue PGT. Results. Among 1218 (69.5%) respondents, 37...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28714016/elastin%C3%A2-derived-peptides-are-involved-in-the-processes-of-human-temporomandibular-disorder-by-inducing-inflammatory-responses-in-synovial-cells
#2
Kazuhiko Kobayashi, Rei Jokaji, Mayuko Miyazawa-Hira, Shigeyuki Takatsuka, Akira Tanaka, Kazuhiro Ooi, Hiroyuki Nakamura, Shuichi Kawashiri
Temporomandibular joint dysfunction (TMD) is a collection of clinical symptoms that involve masticatory muscles and the temporomandibular joint (TMJ). Common symptoms include limited jaw motion and joint sound/pain, along with TMJ disc displacement. TMD is frequently associated with synovitis, a chronic inflammation of the synovium. Fibroblast‑like synovial cells have been identified to produce several inflammatory mediators and may have an important role in the progression of TMJ inflammation. Degradation of the extracellular matrix molecule elastin may lead to the release of bioactive peptides...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28712772/spatio-temporal-variations-in-bloom-of-the-red-tide-dinoflagellate-karenia-mikimotoi-in-imari-bay-japan-in-2014-factors-controlling-horizontal-and-vertical-distribution
#3
Kazuhiro Aoki, Takahiko Kameda, Toshifumi Yamatogi, Naoya Ishida, Sou Hirae, Mayumi Kawaguchi, Toshio Syutou
A massive bloom of the dinoflagellate Karenia mikimotoi appeared in 2014 in Imari Bay, Japan. Bloom dynamics and hydrographical conditions were examined by field survey. The bloom initially developed in the eastern area of Imari Bay, subsequently after rainfall during the neap tides, cell density exceeded over 10,000cellsml. Vertical distribution of K. mikimotoi was primarily controlled by the light intensity and secondarily by the water quality during the daytime. Almost all cell-density maxima occurred in depths with weak daytime light intensities of <300μmolm(-2)s(-1)...
July 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28711640/recent-advances-in-tpgs-based-nanoparticles-of-docetaxel-for-improved-chemotherapy
#4
REVIEW
Hira Choudhury, Bapi Gorain, Manisha Pandey, Santosh Ashok Kumbhar, Rakesh Kumar Tekade, Arun K Iyer, Prashant Kesharwani
Docetaxel (DTX) is one of the important antitumor drugs, being used in several common chemotherapies to control leading cancer types. Severe toxicities of the DTX are prominent due to sudden parenteral exposure of desired loading dose to maintain the therapeutic concentration. Field of nanotechnology is leading to resist sudden systemic exposure of DTX with more specific delivery to the site of cancer. Further nanometric size range of the formulation aid for prolonged circulation, thereby extensive exposure results better efficacy...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28705849/anaplastic-carcinoma-of-thyroid-gland-with-widespread-soft-tissue-metastasis-an-unusual-presentation
#5
Muhammad Hassan, Taimoor Khalid Janjua, Hira Khan Afridi, Naila Anjum Zahid
Anaplastic thyroid cancer is the rarest tumour of the thyroid gland, representing only 2% of clinically recognised thyroid cancers. The most common metastatic sites are lungs, followed by the intrathoracic and neck lymph nodes. We report the case of a 62-year-old woman who presented to our setting with multiple soft tissue nodules, thyroid mass, head swelling and weight loss. Radiological investigation showed a large thyroid mass with widespread metastasis in subcutaneous tissues of both upper limbs, chest and abdomen...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28704245/inciting-events-associated-with-lumbar-facet-joint-pain
#6
Charles A Odonkor, Yian Chen, Peju Adekoya, Bryan J Marascalchi, Hira Chaudhry-Richter, Teresa Tang, Christopher Abruzzese, Berklee K Cohen, Steven P Cohen
BACKGROUND: Low back pain is the leading cause of years lost to disability with approximately 15%-25% of the chronic back pain population suffering from lumbar facet arthropathy. No large-scale study has sought to systematically identify inciting events for lumbar facet arthropathy. The aim of this study is to quantify the proportion of individuals with lumbar facetogenic pain who report a specific precipitating event(s) and to determine if there is a correlation between these events and treatment outcome...
July 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28698830/prevalence-and-predictors-of-home-use-of-glucometers-in-diabetic-patients
#7
Syed A Farhan, Ali T Shaikh, Maria Zia, Bilal R Kahara, Ramsha Muneer, Muzna Rehman, Ayesha Mubashir, Hassaan Sadiq, Durr-E-Amna Siddiqui, Syed M Haseeb, Hafsa Tanveer, Khadijah Siddiq, Saib B Mujtaba, Samir A Mirza, Hira Feroz, Kaneez Fatima
BACKGROUND: Self-monitoring of blood glucose (SMBG) is a critical component of diabetes care. However, it has been shown that use of glucometers in developing countries such as Pakistan is limited. The aim of this study was to determine the frequency of glucometer usage in the urban diabetic population of Karachi and to identify variables that influenced the likelihood of practice of SMBG. METHODS: A cross-sectional study was conducted among 567 adult diabetic patients selected at random from the out-patient departments of multiple healthcare institutions in Karachi categorized into two settings; Government and Private...
June 10, 2017: Curēus
https://www.readbyqxmd.com/read/28694023/reactivity-toward-bifidobacterium-longum-and-enterococcus-hirae-demonstrate-robust-cd8-t-cell-response-and-better-prognosis-in-hbv-related-hepatocellular-carcinoma
#8
Yihui Rong, Zheng Dong, Zhixian Hong, Yun Jin, Wei Zhang, Bailong Zhang, Wei Mao, Huifang Kong, Chunping Wang, Bin Yang, Xudong Gao, Zhenyu Song, Susan E Green, Haihan K Song, Hongbo Wang, Yinying Lu
Recent studies suggest that several bacterial species are involved in tumor immunosurveillance and antitumor immunity. The role of bacteria in immune responses in HBV-related hepatocellular carcinoma (HCC) patients is still unknown. In this study, we examined the bacteria-reactive CD8(+) T cell response in patients with HBV-related HCC. We found that circulating CD8(+) T cells from healthy individuals demonstrated minimal or zero specificity toward a series of commensals and bacteria previously associated with antitumor effects, including Escherichia coli, Enterococcus faecium, Bifidobacterium longum, Bacteroides fragilis, and Enterococcus hirae...
July 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28686322/characteristics-of-frequent-emergency-department-users-with-type-2-diabetes-mellitus-in-korea
#9
Morena Ustulin, Junghoon Woo, Jeong-Taek Woo, Sang Youl Rhee
AIMS/INTRODUCTION: Frequent emergency department (ED) visitors are medically vulnerable subjects. We identified the characteristics of "frequent ED users" among Korean patients with type 2 diabetes mellitus (DM). MATERIALS AND METHODS: We used the Health Insurance Review and Assessment Service National Patient Sample HIRA-(NPS), which is a nationally representative sample. Subjects (n = 109,412) with type 2 DM as a primary or secondary diagnosis at one of their visits were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28684426/arabidopsis-atrx-modulates-h3-3-occupancy-and-fine-tunes-gene-expression
#10
Céline Duc, Matthias Benoit, Gwénaëlle Détourné, Lauriane Simon, Axel Poulet, Matthieu Jung, Alaguraj Veluchamy, David Latrasse, Samuel Le Goff, Sylviane Cotterell, Christophe Tatout, Moussa Benhamed, Aline V Probst
Histones are essential components of the nucleosome, the major chromatin subunit that structures linear DNA molecules and regulates access of other proteins to DNA. Specific histone chaperone complexes control the correct deposition of canonical histones and their variants to modulate nucleosome structure and stability. In this study, we characterize the Arabidopsis Alpha Thalassemia-mental Retardation X-linked (ATRX) ortholog and show that ATRX is involved in histone H3 deposition. Arabidopsis ATRX mutant alleles are viable, but show developmental defects and reduced fertility...
July 6, 2017: Plant Cell
https://www.readbyqxmd.com/read/28684064/protective-role-of-vitamin-e-preconditioning-of-human-dermal-fibroblasts-against-thermal-stress-in-vitro
#11
Hira Butt, Azra Mehmood, Muhammad Ali, Saba Tasneem, Muhammad Sohail Anjum, Moazzam N Tarar, Shaheen N Khan, Sheikh Riazuddin
AIMS: Oxidative microenvironment of burnt skin restricts the outcome of cell based therapies of thermal skin injuries. The aim of this study was to precondition human dermal fibroblasts with an antioxidant such as vitamin E to improve their survival and therapeutic abilities in heat induced oxidative in vitro environment. MAIN METHODS: Fibroblasts were treated with 100μM vitamin E for 24h at 37°C followed by heat shock for 10min at 51°C in fresh serum free medium...
July 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/28680514/validating-a-point-of-care-lactate-meter-in-adult-patients-with-sepsis-presenting-to-the-emergency-department-of-a-tertiary-care-hospital-of-a-low-to-middle-income-country
#12
Muhammad Akbar Baig, Hira Shahzad, Erfan Hussain, Asad Mian
BACKGROUND: Timely identification of high blood lactate levels in septic patients may allow faster detection of those patients requiring immediate resuscitation. Point-of-care (POC) testing is being increasingly utilized in the emergency department (ED). We examined the accuracy and time-saving effect of a handheld POC lactate device for the measurement of fingertip and whole blood lactate as compared with reference laboratory blood testing in septic ED patients. METHODS: A convenience sample of adult ED patients receiving serum lactate testing were enrolled prospectively in the ED of a multidisciplinary tertiary care hospital serving the population of one of the major cities of Pakistan...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28680050/whole-genome-sequencing-of-live-attenuated-leishmania-donovani-parasites-reveals-novel-biomarkers-of-attenuation-and-enables-product-characterization
#13
Sreenivas Gannavaram, John Torcivia, Lusine Gasparyan, Amit Kaul, Nevien Ismail, Vahan Simonyan, Hira L Nakhasi
No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen (-/-)) showed protective immunity in animal models. Such studies typically examined the biomarkers of protective immunity however the biomarkers of attenuation in the parasite preparations have not received adequate attention...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679922/a-review-of-the-factors-associated-with-the-adoption-of-accounting-information-systems-in-gulf-countries
#14
Hadal Hammour, Mowafa Househ, Hira Abdul Razzak
This review attempts to elucidate the significance of accounting information systems within healthcare settings in the Gulf regions. Information and communication technologies (ICT) has provided accounting system the ability to help an organization use and develop computerized systems to record and track financial transactions. Accounting information systems, if well implemented, can permit healthcare sectors in the Gulf regions to produce reports that can support the decision making process. Additional abilities of an accounting information systems include faster processing, enriched accuracy, amplified functionality, and improved external reporting...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28679921/accounting-information-systems-in-healthcare-a-review-of-the-literature
#15
Hadal Hammour, Mowafa Househ, Hira Abdul Razzak
As information technology progresses in Saudi Arabia, the manual accounting systems have become graduallyinadequate for decision needs. Subsequently, private and public healthcare divisions in Saudi Arabia perceive Computerized accounting information system (CAIS) as a vehicle to safeguard efficient and effective flow of information during the analysis, processes, and recording of financial data. Efficient and effective flow of information improvesthe decision making of staff, thereby improving the capability of health care sectors to reduce cost of the medical services...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28678219/frontal-subcortical-defects-correlate-with-task-switching-deficits-in-parkinson-s-disease
#16
Amara Gul, Javed Yousaf, Hira Ahmad
OBJECTIVE: To examine correlation between frontal-subcortical/ parietal-cortical functioning and task switching. METHODS: An experimental study was designed to examine objectives with 80 participants (40 patients with idiopathic Parkinson`s disease (PD) and 40 healthy controls). Patients were recruited from February until September 2016 at Recep Tayyip Erdogan Hospital Pakistan, Muzaffargarh, Pakistan and healthy controls participated from community. Participants were administered Parkinson`s disease cognitive rating scale and Word-Digit categorization task switching experiment...
July 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28678211/incidence-and-impact-of-stroke-during-hajj-results-of-2015-hajj-stroke-registry
#17
Mohammed A Almekhlafi, Maher A Alhazmi, Sarah S Alsulami, Soha A Almorsy
OBJECTIVE: To investigate the incidence of stroke among pilgrims and describe factors associated with presentation and management during Hajj. Physical stress, age and vascular risk factors render pilgrims at a high risk of stroke. METHODS: This is a prospective registry of all acute stroke patients admitted to 6 hospitals during the 2015 Hajj season from 9 September to 4 November. Participating hospitals were King Abdullah Medical City (KAMC), Al-Noor, King Abdulaziz hospital, King Faisal hospital, Hira, and Mena general hospitals; all in Makkah city...
July 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28678049/impact-of-abcb1-abcg2-and-cyp3a5-polymorphisms-on-plasma-trough-concentrations-of-apixaban-in-japanese-patients-with-atrial-fibrillation
#18
Satoshi Ueshima, Daiki Hira, Ryo Fujii, Yuuma Kimura, Chiho Tomitsuka, Takuya Yamane, Yohei Tabuchi, Tomoya Ozawa, Hideki Itoh, Minoru Horie, Tomohiro Terada, Toshiya Katsura
OBJECTIVES: During anticoagulant therapy, major bleeding is one of the most severe adverse effects. This study aimed to evaluate the relationships between ABCB1, ABCG2, and CYP3A5 polymorphisms and plasma trough concentrations of apixaban, a direct inhibitor of coagulation factor X. PATIENTS AND METHODS: A total of 70 plasma concentrations of apixaban from 44 Japanese patients with atrial fibrillation were analyzed. In these analyses, the plasma trough concentration/dose (C/D) ratio of apixaban was used as a pharmacokinetic index and all data were stratified according to the presence of ABCB1 (ABCB1 1236C>T, 2677G>T/A, and 3435C>T), ABCG2 (ABCG2 421C>A), and CYP3A5 (CYP3A5*3) polymorphisms...
July 3, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28669690/the-relationship-of-cd34-dosage-and-platelet-recovery-following-high-dose-chemotherapy-and-autologous-cd34-reinfusion-in-multiple-myeloma
#19
Robert M G Martin, Michael J Ricci, Ronan Foley, Hira S Mian
Autologous hematopoietic stem cell transplantation (ASCT) is an established treatment for multiple myeloma (MM), yet the impact of transplanted CD34+ cell dose remains unresolved, especially in patients over the age of 65 years. Data was collected from 207 consecutive ASCT patients to determine the relationship between CD34+ infusion count and short-term and long-term platelet recovery. For MM patients under the age of 65 years (n=155), CD34+ dosage correlates with time to platelet engraftment (p<0.001) and platelet count at 30 days (p=0...
June 15, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28659810/expression-localization-of-sumo-1-and-analyses-of-potential-sumoylated-proteins-in-bubalus-bubalis-spermatozoa
#20
Rahim Dad Brohi, Li Wang, Najla Ben Hassine, Jing Cao, Hira Sajjad Talpur, Di Wu, Chun-Jie Huang, Zia-Ur Rehman, Dinesh Bhattarai, Li-Jun Huo
Mature spermatozoa have highly condensed DNA that is essentially silent both transcriptionally and translationally. Therefore, post translational modifications are very important for regulating sperm motility, morphology, and for male fertility in general. Protein sumoylation was recently demonstrated in human and rodent spermatozoa, with potential consequences for sperm motility and DNA integrity. We examined the expression and localization of small ubiquitin-related modifier-1 (SUMO-1) in the sperm of water buffalo (Bubalus bubalis) using immunofluorescence analysis...
2017: Frontiers in Physiology
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