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https://www.readbyqxmd.com/read/29153247/early-versus-delayed-appendectomy-a-comparison-of-outcomes
#1
Kyle Seudeal, Hira Abidi, Saad Shebrain
BACKGROUND: The optimal timing for performing appendectomy in adults remains controversial. METHOD: A one-year retrospective review of adult patients with acute appendicitis who underwent appendectomy. The cohort was divided by time-to-intervention into two groups: patients who underwent appendectomy within 8 h (group 1), and those who had surgery after 8 h (group 2). Outcome measures including perioperative morbidity and mortality, post-operative length of stay, and the 30-day readmission rate were compared between the two groups...
November 11, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29151564/-patterns-and-influential-factors-of-inter-regional-migration-of-new-and-experienced-nurses-in-2011-2015
#2
Bohyun Park, Se Young Kim
PURPOSE: The purpose of this study was to analyze the migration patterns of new nurses and experienced nurses and to identify the factors influencing inter-regional migration for solving regional imbalances of clinical nurses in South Korea. METHODS: This study involved a secondary analysis of data from the Health Insurance Review and Assessment Service (HIRA). Data were analyzed using descriptive statistics and multiple logistic regression analysis. RESULTS: New nurses tended to migrate from Kyunggi to Seoul...
October 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29147090/detection-of-antibiotic-resistance-and-resistance-genes-in-enterococci-isolated-from-sucuk-a-traditional-turkish-dry-fermented-sausage
#3
Furkan Demirgül, Yasin Tuncer
The aim of this study was to isolate enterococci in Sucuk, a traditional Turkish dry-fermented sausage and to analyze isolates for their biodiversity, antibiotic resistance patterns and the presence of some antibiotic resistance genes. A total of 60 enterococci strains were isolated from 20 sucuk samples manufactured without using a starter culture and they were identified as E. faecium (73.3%), E. faecalis (11.7%), E. hirae (8.3%), E. durans (3.3%), E. mundtii (1.7%) and E. thailandicus (1.7%). Most of the strains were found resistant to rifampin (51...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29145327/current-practice-and-usual-care-of-major-cervical-disorders-in-korea-a-cross-sectional-study-of-korean-health-insurance-review-and-assessment-service-national-patient-sample-data
#4
A Ryeon Choi, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Min-Seok Oh, Eun-Jung Lee, Sungchul Kim, Mia Kim, In-Hyuk Ha
Neck pain is a highly common condition and is the 4th major cause of years lived with disability. Previous literature has focused on the effect of specific treatments, and observations of actual practice are lacking to date. This study examined Korean health insurance review and assessment service (HIRA) claims data to the aim of assessing prevalence and comparing current medical practice and costs of cervical disorders in Korea.Current practice trends were determined through assessment of prevalence, total expenses, per-patient expense, average days in care, average days of visits, sociodemographic characteristics, distribution of medical costs, and frequency of treatment types of high frequency cervical disorders (cervical sprain/strain, cervical intervertebral disc displacement [IDD], and cervicalgia)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125667/diversity-of-dimerization-behaviors-of-n-substituted-dicyanomethyl-radicals-boundary-between-dynamically-stabilized-radicals-and-a-stable-radical
#5
Kohei Okino, Daisuke Sakamaki, Shota Hira, Yuki Inoue, Shu Seki
Herein we demonstrate the characteristic switching of the dimerization behaviors of amine-substituted dicyanomethyl radicals, from - to -dimerization, simply by varying the electron-donating substituents. Dicyanomethyl radicals with 4,4'-ditolylamine (DT·) and with phenothiazine (PT·) are in equilibrium between the monomeric radical form and the corresponding dimer connected by a reversible C-C bond (-dimer) in solutions. On the other hand, a radical with julolidine skeleton (JD·) do not undergo -dimerization and is isolated as stable radical in spite of the absence of bulky protecting groups...
November 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29120971/a-systematic-review-of-salivary-versus-blood-concentrations-of-anti-tuberculosis-drugs-and-their-potential-for-salivary-therapeutic-drug-monitoring
#6
Simone H J van den Elsen, Lisette M Oostenbrink, Scott K Heysell, Daiki Hira, Daan J Touw, Onno W Akkerman, Mathieu S Bolhuis, Jan-Willem C Alffenaar
BACKGROUND: Therapeutic drug monitoring is useful in the treatment of tuberculosis to assure adequate exposure, minimize antibiotic resistance, and reduce toxicity. Salivary therapeutic drug monitoring could reduce the risks, burden, and costs of blood-based therapeutic drug monitoring. This systematic review compared human pharmacokinetics of anti-tuberculosis drugs in saliva and blood to determine if salivary therapeutic drug monitoring could be a promising alternative. METHODS: On December 2, 2016, PubMed and the Institute for Scientific Information Web of Knowledge were searched for pharmacokinetic studies reporting human salivary and blood concentrations of anti-tuberculosis drugs...
November 8, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29111433/longitudinal-study-on-antimicrobial-consumption-and-resistance-in-rabbit-farming
#7
Fabrizio Agnoletti, Romina Brunetta, Luca Bano, Ilenia Drigo, Elena Mazzolini
Reliable indicators of antimicrobial consumption (AMC) measured with harmonized data and supported with indicators for antimicrobial resistance (AMR) at herd level are necessary to target antimicrobial misuse in food producing animals. To this scope in 2010-2015 we collected AMC data in 32 Italian industrial rabbit holdings weighted with semester production and standardized with animal daily dose (ADD). Herd level AMR against eight antimicrobials was assessed in E. coli, E. faecalis and E. hirae collected in 2014 and 2015...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29109478/a-bacterial-pioneer-produces-cellulase-complexes-that-persist-through-community-succession
#8
Sebastian Kolinko, Yu-Wei Wu, Firehiwot Tachea, Evelyn Denzel, Jennifer Hiras, Raphael Gabriel, Nora Bäcker, Leanne Jade G Chan, Stephanie A Eichorst, Dario Frey, Qiushi Chen, Parastoo Azadi, Paul D Adams, Todd R Pray, Deepti Tanjore, Christopher J Petzold, John M Gladden, Blake A Simmons, Steven W Singer
Cultivation of microbial consortia provides low-complexity communities that can serve as tractable models to understand community dynamics. Time-resolved metagenomics demonstrated that an aerobic cellulolytic consortium cultivated from compost exhibited community dynamics consistent with the definition of an endogenous heterotrophic succession. The genome of the proposed pioneer population, 'Candidatus Reconcilibacillus cellulovorans', possessed a gene cluster containing multidomain glycoside hydrolases (GHs)...
November 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29105244/spinal-cord-stimulation-for-treating-chronic-pain-reviewing-preclinical-and-clinical-data-on-paresthesia-free-high-frequency-therapy
#9
REVIEW
Krishnan Chakravarthy, Hira Richter, Paul J Christo, Kayode Williams, Yun Guan
BACKGROUND: Traditional spinal cord stimulation (SCS) requires that paresthesia overlaps chronic painful areas. However, the new paradigm high-frequency SCS (HF-SCS) does not rely on paresthesia. STUDY DESIGN: A review of preclinical and clinical studies regarding the use of paresthesia-free HF-SCS for various chronic pain states. METHODS: We reviewed available literatures on HF-SCS, including Nevro's paresthesia-free ultra high-frequency 10 kHz therapy (HF10-SCS)...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29103014/giant-calvarial-haemangioma-with-classical-radiological-features
#10
Surya Nandan Prasad, Upendra Chaudhary, Madhuri Kumari, Hira Lal
No abstract text is available yet for this article.
November 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29097494/gut-microbiome-influences-efficacy-of-pd-1-based-immunotherapy-against-epithelial-tumors
#11
Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P M Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Remon Masip, Charles Naltet, Solenn Brosseau, Coureche Kaderbhai, Corentin Richard, Hira Rizvi, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Nicolas Pons, Bernhard Ryffel, Véronique Minard-Colin, Patrick Gonin, Jean-Charles Soria, Eric Deutsch, Yohann Loriot, François Ghiringhelli, Gérard Zalcman, François Goldwasser, Bernard Escudier, Matthew D Hellmann, Alexander Eggermont, Didier Raoult, Laurence Albiges, Guido Kroemer, Laurence Zitvogel
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizeable minority of cancer patients. Here, we show that primary resistance to ICI can be due to abnormal gut microbiome composition. Antibiotics (ATB) inhibited the clinical benefit of ICI in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICI (but not from non-responding patients) into germ-free or ATB-treated mice ameliorated the antitumor effects of PD-1 blockade...
November 2, 2017: Science
https://www.readbyqxmd.com/read/29097083/knockdown-of-melatonin-receptor-1-and-induction-of-follicle-stimulating-hormone-on-the-regulation-of-mouse-granulosa-cell-function
#12
Hira Sajjad Talpur, Tesfaye Worku, Zia Ur Rehman, Rahim Dad, Dinesh Bhattarai, Iqra Bano, Farmanullah, Aixin Liang, Changjiu He, Liguo Yang
Melatonin receptor 1 (MT1) performs a critical role in the regulation of the animal reproductive system, particularly in follicular growth, and has a considerable effect on reproductive performance. However, the role that MT1 plays in regulating hormones associated with reproduction remains unclear. This study was designed to examine the physiological role of constitutive MT1 silencing and follicle stimulating hormone (FSH) treatment in reproduction, making use of mouse granulosa cells (mGCs) as a model. To understand the constitutive role of MT1 in ovarian physiology, the RNAi-Ready pSIREN-RETROQ-ZsGreen Vector mediated recombinant pshRNA was used to silence MT1 gene expression...
October 30, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29095281/disease-burden-of-hospitalized-community-acquired-pneumonia-in-south-korea-analysis-based-on-age-and-underlying-medical-conditions
#13
Min Joo Choi, Joon Young Song, Ji Yun Noh, Jin Gu Yoon, Saem Na Lee, Jung Yeon Heo, Jae Won Yoon, Yu Mi Jo, Hee Jin Cheong, Woo Joo Kim
Pneumonia is a leading cause of hospitalization and mortality worldwide. Despite recognition of the importance of community-acquired pneumonia (CAP) in adults, limited epidemiologic information is available in South Korea. This study aimed to evaluate the disease burden of hospitalized CAP in adults aged ≥19 years and its epidemiologic trend using Health Insurance and Review Assessment (HIRA) data.This is a retrospective study using the HIRA database from year 2009 to 2013. We estimated the incidence rate and direct medical cost of hospitalized CAP in adults aged ≥19 years in South Korea...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29089636/ly6c-hi-inflammatory-monocytes-promote-susceptibility-to-leishmania-donovani-infection
#14
Cesar Terrazas, Sanjay Varikuti, Steve Oghumu, Heidi M Steinkamp, Nurittin Ardic, Jennifer Kimble, Hira Nakhasi, Abhay R Satoskar
Ly6C(hi) inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their role in leishmaniasis is unclear. In this study, we report a detrimental role of Ly6C(hi) iMOs in visceral leishmaniasis (VL) caused by Leishmania donovani. We demonstrate that Ly6C(hi) iMOs are continuously recruited into the spleen and liver during L. donovani infection and they are preferential targets for the parasite. Using microarray-based gene expression profiling, we show that Ly6C(hi) iMOs isolated from the infected liver and spleen have distinct phenotypic and activation profiles...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089137/ambient-temperature-and-hospital-admissions-for-acute-kidney-injury-a-time-series-analysis
#15
Youn-Hee Lim, Rina So, Choongho Lee, Yun-Chul Hong, Minseon Park, Logyoung Kim, Hyung-Jin Yoon
Some studies have suggested that high ambient temperatures are a risk factor for kidney-related diseases. However, none have examined the association between ambient temperature and acute kidney injury (AKI). This study aimed to examine the association between daily mean temperature and AKI and identify high-risk subgroups in this association. We obtained health insurance claim data from the Health Insurance Review and Assessment Service (HIRA) for 24,800 admitted cases of AKI during the period 2007-2014 in Seoul, Korea...
October 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29081464/an-investigation-of-enterococcus-species-isolated-from-the-african-buffalo-syncerus-caffer-in-serengeti-national-park-tanzania
#16
Eunju Shin, Simon Mduma, Julius Keyyu, Robert Fyumagwa, Yeonhee Lee
We isolated Enterococcus species that colonized in the African buffalo (Syncerus caffer) in order to investigate their genetic relatedness and antimicrobial susceptibility. A total of 219 isolates were obtained and a 16S rRNA gene sequence analysis showed they were classified into Enterococcus avium, E. casseliflavus, E. faecalis, E. faecium, E. hirae, or E. mundtii. Multilocus sequence typing of E. faecalis and E. faecium isolates indicated that some of the isolates showed an evolutionary distance that was far from the primary founders...
October 28, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/29080846/safety-against-nephrotoxicity-in-paclitaxel-treatment-oral-nanocarrier-as-an-effective-tool-in-preclinical-evaluation-with-marked-in-vivo-antitumor-activity
#17
Hira Choudhury, Bapi Gorain, Rakesh Kumar Tekade, Manisha Pandey, Sanmoy Karmakar, Tapan Kumar Pal
Oral paclitaxel (PTXL) formulations freed from cremophor(®) EL (CrEL) is always in utmost demand by the cancerous patients due to toxicities associated with the currently marketed formulation. In our previous investigation [Int. J. Pharm. 2014; 460:131], we have developed an oral oil based nanocarrier for the lipophilic drug, PTXL to target bioavailability issue and patient compliance. Here, we report in vivo antitumor activity and 28-day sub-chronic toxicity of the developed PTXL nanoemulsion. It was observed that the apoptotic potential of oral PTXL nanoemulsion significantly inhibited the growth of solid tumor (59...
November 3, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29076668/efficacy-of-two-regimens-of-dexamethasone-for-management-of-preterm-labour-pilot-study
#18
Ahsan Rasool, Umer Farooq, Qurat-Ul-Ann Nazir, Hira Bahar Durani
BACKGROUND: Dexamethasone is widely used for prevention of respiratory distress syndrome (RDS), necrotising enterocolitis (NEC) and intra-ventricular haemorrhage (IVH) in preterm babies; decreasing the neonatal mortality rate. There is no consensus on the dose of corticosteroid administered to the mother expected to have a preterm baby. This study is conducted to compare the effectiveness of two popular regimens of dexamethasone administration in decreasing incidence of RDS, necrotizing enterocolitis, IVH and neonatal mortality rate...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29073958/status-of-early-career-academic-cardiology-a-global-perspective
#19
REVIEW
Carl W Tong, Meena S Madhur, Anne K Rzeszut, Marwah Abdalla, Islam Abudayyeh, Erick Alexanderson, Jonathan Buber, Dmitriy N Feldman, Rakesh Gopinathannair, Ravi S Hira, Andrew M Kates, Thorsten Kessler, Steve Leung, Satish R Raj, Erica S Spatz, Melanie B Turner, Anne Marie Valente, Kristin West, Chittur A Sivaram, Joseph A Hill, Douglas L Mann, Andrew M Freeman
Early-career academic cardiologists, who many believe are an important component of the future of cardiovascular care, face myriad challenges. The Early Career Section Academic Working Group of the American College of Cardiology, with senior leadership support, assessed the progress of this cohort from 2013 to 2016 with a global perspective. Data consisted of accessing National Heart, Lung, and Blood Institute public information, data from the American Heart Association and international organizations, and a membership-wide survey...
October 31, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29055593/distribution-of-species-and-antimicrobial-resistance-among-enterococci-isolated-from-the-fecal-microbiota-of-captive-blue-fronted-parrot-amazona-aestiva-in-rio-de-janeiro-brazil
#20
Andréa de Andrade Rangel de Freitas, Adriana Rocha Faria, Tatiana de Castro Abreu Pinto, Vânia Lúcia Carreira Merquior, Daniel Marchesi Neves, Rodrigo de Cerqueira da Costa, Lúcia Martins Teixeira
Enterococcal strains recovered from fecal samples of captive blue-fronted parrots (Amazona aestiva) assisted at two wild animal screening centers in Rio de Janeiro, Brazil, were identified as Enterococcus hirae (the predominant species; 75.3%), followed by Enterococcus faecalis (17.3%), Enterococcus casseliflavus (4.8%), Enterococcus gallinarum (1.7%), and Enterococcus hermanniensis (0.9%). All strains were susceptible to linezolid and teicoplanin. Rates of nonsusceptibility (including resistant and intermediate categories) to other 16 antimicrobials tested varied from 69...
February 15, 2018: Science of the Total Environment
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