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https://www.readbyqxmd.com/read/28208755/micrornas-new-insight-in-modulating-follicular-atresia-a-review
#1
REVIEW
Tesfaye Worku, Zia Ur Rehman, Hira Sajjad Talpur, Dinesh Bhattarai, Farman Ullah, Ngabu Malobi, Tesfaye Kebede, Liguo Yang
Our understanding of the post-transcriptional mechanisms involved in follicular atresia is limited; however, an important development has been made in understanding the biological regulatory networks responsible for mediating follicular atresia. MicroRNAs have come to be seen as a key regulatory actor in determining cell fate in a wide range of tissues in normal and pathological processes. Profiling studies of miRNAs during follicular atresia and development have identified several putative miRNAs enriched in apoptosis signaling pathways...
February 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28188322/tennis-ball-sign-a-ct-sign-of-acute-aortic-dissection
#2
REVIEW
Hira Lal, Priyank Yadav, Anand Chellappan, Rajeev Singh
No abstract text is available yet for this article.
February 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28187689/evaluation-of-antihypertensive-potential-of-ficus-carica-fruit
#3
Alamgeer, Shifa Iman, Hira Asif, Muhammad Saleem
CONTEXT: Ficus carica L. (Moraceae) fruit is said to possess cardiovascular activity and has been used empirically in traditional phytotherapies for the treatment of hypertension and various other cardiovascular diseases. OBJECTIVE: This study investigated the antihypertensive and cardioinhibitory activity of the aqueous-methanol extract of F. carica fruit in rats. MATERIALS AND METHODS: Extract in 250, 500 and 1000 mg/kg doses (p.o.) were administered to normotensive Sprague Dawley rats and blood pressure was measured using non-invasive technique...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28166996/the-protective-role-of-tetramethylpyrazine-against-cisplatin-induced-ototoxicity
#4
Ali Bayram, Altan Kaya, Ebru Akay, İbrahim Hıra, İbrahim Özcan
OBJECTIVES: The aim of the present study was to investigate the protective effect of tetramethylpyrazine (TMP) on cisplatin-induced ototoxicity in rats. METHODS: Forty healthy, female, 24-week-old, Sprague-Dawley rats (n = 40) were randomly assigned to four groups as follows: group one (n = 10) received intraperitoneal (i.p.) physiological saline at daily doses of 3 mg/kg for seven days; group two (n = 10) received a single dose of i.p. 15 mg/kg cisplatin; group three (n = 10) received i...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28161724/resistant-maltodextrin-or-fructooligosaccharides-promotes-glp-1-production-in-male-rats-fed-a-high-fat-and-high-sucrose-diet-and-partially-reduces-energy-intake-and-adiposity
#5
Tohru Hira, Ryoya Suto, Yuka Kishimoto, Sumiko Kanahori, Hiroshi Hara
PURPOSE: Increasing secretion and production of glucagon-like peptide-1 (GLP-1) by continuous ingestion of certain food components has been expected to prevent glucose intolerance and obesity. In this study, we examined whether a physiological dose (5% weight in diet) of digestion-resistant maltodextrin (RMD) has a GLP-1-promoting effect in rats fed a high-fat and high-sucrose (HFS) diet. METHODS: Rats were fed a control diet or the HFS (30% fat, 40% sucrose wt/wt) diet supplemented with 5% RMD or fructooligosaccharides (FOS) for 8 weeks or for 8 days in separated experiments...
February 4, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28154906/perirenal-fluid-collection-in-renal-parenchymal-disease-the-kidney-sweat-sign
#6
REVIEW
Hira Lal, Priyank Yadav, Anand Chellappan, Abhay Kumar
No abstract text is available yet for this article.
February 2, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28138170/comparison-of-two-interactive-tutorial-methods-results-from-a-medical-college-in-karachi
#7
Rabiya Rehan, Lubna Farooqi, Hira Khan, Rehana Rehman
OBJECTIVE: To compare perception of students on usefulness of interactive tutorials and clinically-oriented problem-solving tutorials. METHODS: The cross-sectional study was carried out from January 2012 to November 2013 at Bahria University Medical and Dental College, Karachi. The perception of medical students on usefulness of interactive tutorials and clinically-oriented problem-solving tutorials was acquired through a questionnaire distributed to medical students having completed the first two years of studies...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28134076/the-prevalence-of-beh%C3%A3-et-s-disease-in-korea-data-from-health-insurance-review-and-assessment-service-from-2011-to-2015
#8
Ji Na Kim, Sang Gyu Kwak, Jung-Yoon Choe, Seong-Kyu Kim
OBJECTIVES: The aim of this study is to identify the prevalence of Behçet's disease (BD) from data in the Healthcare Bigdata Hub of the Health Insurance Review & Assessment (HIRA) Service from 2011 to 2015 in Korea. METHODS: This study collected information on primary and auxiliary diagnoses of BD (M352) by physicians according to the Korean Standard Classification of Diseases (KCD) codes. The prevalence of BD was assessed on the basis of age, sex, and geographical distribution...
January 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28130043/prevalence-age-at-diagnosis-mortality-and-cause-of-death-in-retinitis-pigmentosa-in-korea-a-nationwide-population-based-study
#9
Kun-Hoo Na, Hyun Jung Kim, Kyoung Hoon Kim, Seungjin Han, Patrick Kim, Hoo Jae Hann, Hyeong Sik Ahn
PURPOSE: To determine the prevalence and mortality of retinitis pigmentosa (RP) patients in Korea. DESIGN: Population-based retrospective cohort study METHODS: We used data covering the 2011-2014 period from the Rare Intractable Disease (RID) registry and Health Insurance Review Agency (HIRA), which include information on all patients diagnosed with RP based on predefined diagnostic criteria. Using the HIRA-RID database, the prevalence and age at diagnosis of RP patients across the entire Korean population were evaluated...
January 24, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28116929/evaluation-of-colonisation-resistance-in-stool-of-human-donors-using-ex-vivo-in-vitro-and-in-vivo-assays
#10
M F Galvão, R W Bastos, L B Acurcio, B B Nascimento, S H C Sandes, R M E Arantes, M R Souza, F S Martins, L Q Vieira, J R Nicoli
The indigenous microbiota is the population of microorganisms normally present on the surface and mucosa of an individual, where it performs essential health functions, including the colonisation resistance (CR) against pathogens. To identify the bacteria responsible and the mechanisms involved in the CR, the germ-free (GF) animal model has been used, because in vitro studies cannot always be extrapolated to what occurs in vivo. In this study, ex vivo antagonism assays against seven enteropathogenic bacteria using stools from 15 healthy human donors confirmed that the CR showed individual variation...
January 24, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28107649/rpa-interacts-with-hira-and-regulates-h3-3-deposition-at-gene-regulatory-elements-in-mammalian-cells
#11
Honglian Zhang, Haiyun Gan, Zhiquan Wang, Jeong-Heon Lee, Hui Zhou, Tamas Ordog, Marc S Wold, Mats Ljungman, Zhiguo Zhang
The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions, including promoters, enhancers, and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive. Through a short hairpin RNA (shRNA) screening, we identified single-stranded DNA binding protein replication protein A (RPA) as a regulator of the deposition of newly synthesized H3.3 into chromatin. We show that RPA physically interacts with HIRA to form RPA-HIRA-H3.3 complexes, and it co-localizes with HIRA and H3...
January 19, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28104943/disseminated-gestational-choriocarcinoma-presenting-with-hepatic-and-uveal-metastases-hook-effect-and-choriocarcinoma-syndrome
#12
Yashant Aswani, Hemangini Thakkar, Priya Hira
Choriocarcinoma is a human chorionic gonadotrophin (HCG)-secreting tumor that comprises vascular channels. It has a tendency for widespread metastasis, common sites for which include the lung, vagina, brain, liver, bone, intestine, and kidney. We describe a 30-year-old female who presented with hepatitis-like features and bilateral diminution of vision, and subsequently developed hemothorax and hemoperitoneum-all rare and seemingly unrelated manifestations which were finally attributable to metastases from gestational choriocarcinoma...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28074304/evaluation-of-endothelial-dysfunction-in-patients-with-familial-mediterranean-fever-the-relationship-between-the-levels-of-asymmetric-dimethylarginine-and-endocan-with-carotid-intima-media-thickness-and-endothelium-dependent-vasodilation
#13
Veysel Ozalper, Muammer Kara, Alpaslan Tanoglu, Ibrahim Cetındaglı, Coskun Ozturker, Yusuf Hancerlı, Serdar Hıra, Kemal Kara, Yavuz Beyazıt, Yusuf Yazgan
It has been suggested that there is an ongoing subclinical inflammation in familial Mediterranean fever (FMF) patients also in attack-free periods as well. Due to this ongoing inflammation, endothelial dysfunction (ED) may develop. Previously, ED has been suggested to increase the risk of the atherosclerosis and cardiovascular disease (CVD). Endocan is recognized as a specific molecule of the endothelium and has been shown to increase in some cases associated with inflammation. However, there is not sufficient data whether those with FMF could develop ED in the early period of life...
January 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28065950/awareness-about-human-papillomavirus-as-a-cause-of-cervical-cancer-and-its-prevention-in-the-undergraduate-female-students-of-karachi
#14
Ramsha Zaheer, Nabiha Alam, Kinza Chaudary Faqir Hussain, Anam Asif Herekar, Hira Nasir, Shereen Zulfiqar Bhutta
OBJECTIVE: To determine the rate of acceptance of human papillomavirus vaccine for prevention of cervical cancer, and to identify causes of its low acceptance and means of encouraging its uptake. METHODS: This cross-sectional study was conducted at five different universities of Karachi, from July to December 2011, and comprised female undergraduate students. The participants, aged between 17-26 years, were in their first four years of undergraduate studies, and were selected from five universities...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28056219/antimicrobial-resistant-escherichia-coli-and-enterococcus-spp-isolated-from-miranda-donkey-equus-asinus-an-old-problem-from-a-new-source-with-a-different-approach
#15
Isabel Carvalho, Rosa Del Campo, Margarida Sousa, Nuno Silva, João Carrola, Catarina Marinho, Tiago Santos, Silvia Carvalho, Miguel Nóvoa, Miguel Quaresma, José Eduardo Pereira, Marta Cobo, Gilberto Igrejas, Patricia Poeta
The Miranda Donkey (Equus asinus) is an endangered asinine from Miranda do Douro region, located in North East of Portugal. We study the antimicrobial resistance (AMR) and virulence genes in Escherichia coli and Enterococcus spp. isolates from these animals. In March 2014, a total of 66 faecal samples were recovered from independent animals. Antibiotic resistance was determined by the disk diffusion method. Carriage of genes codifying for antibiotic resistant and virulent factors was analyzed by polymerase chain reaction (PCR)...
January 5, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28050421/the-effect-of-folic-acid-supplementation-on-hyperhomocysteinemia-and-pulmonary-function-parameters-in-chronic-obstructive-pulmonary-disease-a-pilot-study
#16
Naushad Ahmad Khan, Harish Saini, Govind Mawari, Suman Kumar, Harmanjit Singh Hira, Mradul Kumar Daga
INTRODUCTION: Preliminary studies have established the elevated plasma total Homocysteine (tHcy) levels as a risk factor for Chronic Obstructive Pulmonary Disease (COPD). However, studies describing plasma tHcy levels and their relationship to folic acid supplementation and Forced Expiratory Volume in 1 Second (FEV1) status in COPD patients are still lacking. AIM: We investigated the role of hyperhomocysteinemia in COPD and then prospectively examined the relationship between plasma tHcy concentration and effect of folic acid supplementation on FEV1 status in COPD patients...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049250/national-trends-in-surgery-for-rotator-cuff-disease-in-korea
#17
Young Hoon Jo, Kwang Hyun Lee, Sung Jae Kim, Jaedong Kim, Bong Gun Lee
The objective of this study was to investigate the national trends in rotator cuff surgery in Korea and analyze hospital type-specific trends. We analyzed a nationwide database acquired from the Korean Health Insurance Review and Assessment Service (HIRA) from 2007 to 2015. International Classification of Diseases, 10th revision (ICD-10) codes, procedure codes, and arthroscopic device code were used to identify patients who underwent surgical treatment for rotator cuff disease. A total of 383,719 cases of rotator cuff surgeries were performed from 2007 to 2015...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28040478/cathepsin-k-cleavage-of-sdf-1%C3%AE-inhibits-its-chemotactic-activity-towards-glioblastoma-stem-like-cells
#18
Vashendriya V V Hira, Urška Verbovšek, Barbara Breznik, Matic Srdič, Marko Novinec, Hala Kakar, Jill Wormer, Britt Van der Swaan, Brigita Lenarčič, Luiz Juliano, Shwetal Mehta, Cornelis J F Van Noorden, Tamara T Lah
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor patient survival that is at least partly caused by malignant and therapy-resistant glioma stem-like cells (GSLCs) that are protected in GSLC niches. Previously, we have shown that the chemo-attractant stromal-derived factor-1α (SDF-1α), its C-X-C receptor type 4 (CXCR4) and the cysteine protease cathepsin K (CatK) are localized in GSLC niches in glioblastoma. Here, we investigated whether SDF-1α is a niche factor that through its interactions with CXCR4 and/or its second receptor CXCR7 on GSLCs facilitates their homing to niches...
December 28, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28031708/trend-of-cost-and-utilization-of-copd-medication-in-korea
#19
Jongmin Lee, Jae Ha Lee, Jee-Ae Kim, Chin Kook Rhee
BACKGROUND: There are only a few longitudinal studies regarding medical utilization and costs for patients with COPD. The purpose of this study was to analyze the trend of medical utilization and costs on a long-term basis. METHODS: Using the Korean Health Insurance Review and Assessment Service (HIRA) data from 2008 to 2013, COPD patients were identified. The trend of medical utilization and costs was also analyzed. RESULTS: The number of COPD patients increased by 13...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28008735/aorto-pulmonary-calcification-in-twin-twin-transfusion-successful-heart-surgery
#20
Noboru Inamura, Seigo Hira, Shigemitsu Iwai
No abstract text is available yet for this article.
December 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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