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https://www.readbyqxmd.com/read/28515277/histone-chaperone-hira-regulates-neural-progenitor-cell-proliferation-and-neurogenesis-via-%C3%AE-catenin
#1
Yanxin Li, Jianwei Jiao
Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. Subsequent studies have provided evidence that HIRA plays key roles in embryonic development, but its function during early neurogenesis remains unknown. Here, we demonstrate that HIRA is enriched in neural progenitor cells, and HIRA knockdown reduces neural progenitor cell proliferation, increases terminal mitosis and cell cycle exit, and ultimately results in premature neuronal differentiation. Additionally, we demonstrate that HIRA enhances β-catenin expression by recruiting H3K4 trimethyltransferase Setd1A, which increases H3K4me3 levels and heightens the promoter activity of β-catenin...
May 17, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28503391/prevalence-and-predictors-of-use-of-home-sphygmomanometers-among-hypertensive-patients
#2
Hira Zahid, Aisha Amin, Emaan Amin, Summaiya Waheed, Ameema Asad, Ariba Faheem, Samreen Jawaid, Adila Afzal, Sarah Misbah, Kanza Majid
OBJECTIVE: Few studies have looked at the predictors of use of home sphygmomanometers among hypertensive patients in low-income countries such as Pakistan. Considering the importance of home blood pressure monitoring (HBPM), cross-sectional study was conducted to evaluate the prevalence and predictors of the usage of all kinds of HBPM devices. METHOD: This study was conducted in Karachi during the time period of January-February 2017. Adult patients previously diagnosed with hypertension visiting tertiary care hospitals were selected for the study...
April 11, 2017: Curēus
https://www.readbyqxmd.com/read/28502049/evaluation-of-carbofuran-mediated-toxicity-against-human-lymphocytes-and-red-blood-cells-in-simulated-wastewater-degraded-by-coagulation-flocculation
#3
Roli Saini, Pradeep Kumar, Sumit Kumar Hira, Partha Pratim Manna
Coagulation-flocculation in water treatment has been relied upon aluminum (Al) and iron (Fe) salts for treatment of contaminants present in source waters containing dissolved organic compounds. However, water quality deteriorates day by day which makes it urgent to improve the standards of the treatment procedure. Coagulation-flocculation-sedimentation performance of ferric chloride and alum was comparatively investigated for carbofuran treatment in simulated wastewater. Coagulation trails were performed in a jar test at several pH levels and coagulant doses to determine reduction efficiencies of carbofuran degradation and chemical oxygen demand (COD)...
May 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28495136/heritability-of-plasma-neopterin-levels-in-the-old-order-amish
#4
Uttam K Raheja, Dietmar Fuchs, Christopher A Lowry, Sarah H Stephens, Mary A Pavlovich, Hira Mohyuddin, Hassaan Yousufi, Kathleen A Ryan, Jeff O'Connell, Lisa A Brenner, Cecile Punzalan, Andrew J Hoisington, Gursharon K Nijjar, Maureen Groer, Alan R Shuldiner, Toni I Pollin, John W Stiller, Braxton D Mitchell, Teodor T Postolache
BACKGROUND: We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish. METHODS: Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin. RESULTS: Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household (p=0...
June 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28493158/common-variable-immunodeficiency-caused-by-fanc-mutations
#5
Yujin Sekinaka, Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Kanako Mitsui-Sekinaka, Kenichi Honma, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Hideki Muramatsu, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, Shigeaki Nonoyama
Common variable immunodeficiency (CVID) is the most common adult-onset primary antibody deficiency disease due to various causative genes. Several genes, which are known to be the cause of different diseases, have recently been reported as the cause of CVID in patients by performing whole exome sequencing (WES) analysis. Here, we found FANC gene mutations as a cause of adult-onset CVID in two patients. B cells were absent and CD4(+) T cells were skewed toward CD45RO(+) memory T cells. T-cell receptor excision circles (TRECs) and signal joint kappa-deleting recombination excision circles (sjKRECs) were undetectable in both patients...
May 11, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28491111/ficus-hispida-bark-extract-prevents-nociception-inflammation-and-cns-stimulation-in-experimental-animal-model
#6
Md Sariful Islam Howlader, Md Afjalus Siraj, Shubhra Kanti Dey, Arpona Hira, Arif Ahmed, Md Hemayet Hossain
Background. Ficus hispida is traditionally used in the ailment of pain, inflammation, and neurological disorders. The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB). Methods. The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice. Its anti-inflammatory activity was assessed by using carrageenan and histamine induced rat paw oedema test in Wister rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28488226/the-prevalence-of-antibiotic-resistant-bacteria-arb-in-waters-of-the-lower-ballona-creek-watershed-los-angeles-county-california
#7
Stephanie Kawecki, Gary Kuleck, John H Dorsey, Christopher Leary, Michelle Lum
Screening for the prevalence of antibiotic-resistant bacteria (ARB) was done at the Ballona Creek and Wetlands, an urban-impacted wetland system in Los Angeles, California. The goals were (1) to assess the overall prevalence of ARB, and (2) compare differences in ARB abundance and the types of antibiotic resistance (AR) among the following sample types: lagoon water from Del Rey Lagoon, urban runoff from Ballona Creek, and water from the Ballona Wetlands (tidal water flooding in from the adjacent estuary, and ebbing out from the salt marsh)...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28486154/insights-into-quorum-quenching-mechanisms-to-control-membrane-biofouling-under-changing-organic-loading-rates
#8
Hira Waheed, Yeyuan Xiao, Imran Hashmi, David Stuckey, Yan Zhou
A quorum quenching (QQ) consortium comprised of both acyl homoserine lactones (AHLs)- and autoinducer-2 (AI-2)-degrading bacteria, either immobilized in polymer-coated alginate beads or in liquid suspension, was examined for fouling control in lab-scale MBRs under both steady and changing organic loading rates (OLRs). Under steady conditions the QQ consortium retarded biofouling by a factor of 3. However, a continuous increase in OLR vastly reduced the effectiveness of QQ bacteria; the biofouling was retarded only by factors of 1...
May 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28480184/trauma-surgery-without-proper-compensation-under-the-current-korean-national-health-insurance-system
#9
Kyoungwon Jung, Yunjung Heo, John Cook-Jong Lee, Mijin Lee, Suni Son, Hee Suk Park, Joo-Ok Kim, Jeong Hee Lee
PURPOSE: This study aimed to evaluate the situations and problems of the current health insurance fees for trauma surgeries. METHODS: We reviewed the medical records and billing data from trauma surgeries performed in the hospital from August 2012 to July 2014. The name and number of surgeries were investigated and the code and number of operations prescribed by surgeons were compared with the number of cases actually billed to insurance. In addition, the results returned by the Health Insurance Review & Assessment Services (HIRA) after deduction were investigated and compared to verify the insurance review findings...
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28466499/implementation-of-national-institute-for-health-and-care-excellence-nice-guidance-to-measure-iga-with-all-coeliac-screens-can-an-affordable-solution-be-devised
#10
Dylan James Mac Lochlainn, Ravina Hira-Kazal, Helen Varney, John Maher
There has been a dramatic increase in requests for coeliac disease (CD) serological screening using IgA tissue transglutaminase antibodies (IgA-tTG). Recently, the UK National Institute for Health and Care Excellence has revised its guidance, recommending that total IgA should also be measured in all samples. This is justified since false negative results may occur with IgA deficiency. However, implementation of this guidance will incur considerable expense. Tests that measure IgA-tTG antibodies can detect IgA deficiency, indicated by low background signal...
May 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28460943/ancestral-andean-grain-quinoa-as-source-of-lactic-acid-bacteria-capable-to-degrade-phytate-and-produce-b-group-vitamins
#11
Silvana L Carrizo, Cecilia E Montes de Oca, Jonathan E Laiño, Nadia E Suarez, Graciela Vignolo, Jean Guy LeBlanc, Graciela Rollán
The lactic acid bacteria (LAB) microbiota of quinoa grains (QG) and spontaneous sourdough (QSS) was evaluated. Different strains of Lactobacillus (L.) plantarum (7), L. rhamnosus (5), L. sakei (1), Pediococcus (Ped.) pentosaceus (9), Leuconostoc (Leuc.) mesenteroides (1), Enterococcus (E.) casseliflavus (2), E. mundtii (3), E. hirae (1), E. gallinarum (12), Enterococcus sp. (1), and E. hermanniensis (2) were isolated, identified and characterized. Only four strains isolated from QSS and eight strains isolated from QG showed amylolytic activity...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28458354/previous-dosage-of-allopurinol-is-a-strong-determinant-of-febuxostat-efficacy
#12
Hiroyoshi Koide, Daiki Hira, Masayuki Tsujimoto, Yurie Katsube, Tetsuya Minegaki, Takashi Uzu, Yoshito Ikeda, Shin-Ya Morita, Kohshi Nishiguchi, Tomohiro Terada
Febuxostat has currently played pivotal role in the treatment of hyperuricemia, but there is little comprehensive information for the determinants of individual difference in efficacy of febuxostat. Therefore, the present study, a retrospective investigation, was carried out to analyze the effects of patient characteristics on the efficacy of febuxostat. A total of 225 patients who were continuously prescribed the same dose of febuxostat for 8-12 weeks from the initial therapy were enrolled in the present study...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28449574/the-clinical-utilization-of-radiation-therapy-in-korea-between-2011-and-2015
#13
Young-Seok Seo, Mi-Sook Kim, Jin-Kyu Kang, Won-Il Jang, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Jae Sun Yoon
Purpose: The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2011 and 2015. Materials and Methods: We analyzed the claims data from the Health Insurance Review and Assessment Service (HIRA) to estimate the clinical utilization of RT. The source population consisted of all patients who had any of the International Classification of Diseases 10 (ICD-10) cancer diagnoses (C00-C97) and those with diagnostic codes D00-D48, who were also associated with at least one of the procedure codes related to RT...
April 25, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28447910/chemical-and-biological-assessment-of-metal-organic-frameworks-mofs-in-pulmonary-cells-and-in-an-acute-in-vivo-model-relevance-to-pulmonary-arterial-hypertension-therapy
#14
Nura Adam Mohamed, Robert P Davies, Paul D Lickliss, Blerina Ahmetaj-Shala, Daniel M Reed, Hime H Gashaw, Hira Saleem, Gemma R Freeman, Peter M George, John Wort, Daniel Morales-Cano, Bianca Barreira, Teresa D Tetley, Adrian H Chester, Magdi Yacoub, Nicholas S Kirkby, Laura Moreno, Jane A Mitchell
No abstract text is available yet for this article.
January 1, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28430425/environmental-growth-of-enterococci-and-escherichia-coli-in-feedlot-catch-basins-and-a-constructed-wetland-in-the-absence-of-fecal-input
#15
Lisa Tymensen, Calvin W Booker, Sherry J Hannon, Shaun R Cook, Rahat Zaheer, Ron Read, Tim A McAllister
Population structures of fecal indicator bacteria (FIB) isolated from catch basins, a constructed wetland, and feces from a beef cattle feedlot were compared over a two-year period. Enterococcus hirae accounted for 92% of the fecal isolates, whereas secondary environments were characterized by greater relative abundance of environmentally adapted species including Enterococcus casseliflavus. While enterococci densities in the catch basins and wetland were similar under wet and drought conditions, E. hirae predominated during rainy periods, while E...
May 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28427899/energy-and-information-flows-in-biological-systems-bioenergy-transduction-of-v1-atpase-rotary-motor-and-dynamics-of-thermodynamic-entropy-in-information-flows
#16
REVIEW
Ichiro Yamato, Takeshi Murata, Andrei Khrennikov
We classify research fields in biology with respect to flows of materials, energy, and information. We investigate energy transducing mechanisms in biology, using as a representative the typical molecular rotary motor V1-ATPase from a bacterium Enterococcus hirae. The structures of several intermediates of the rotary motor are described and the molecular mechanism of the motor converting chemical energy into mechanical energy is discussed. Comments and considerations on the information flows in biology, especially on the thermodynamic entropy in quantum physical and biological systems, are presented in section 3 in a biologist friendly manner...
April 17, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28427844/cost-effectiveness-of-influenza-vaccination-in-patients-with-acute-coronary-syndrome-in-korea
#17
Jinuk Suh, Boyeon Kim, Yunseok Yang, Dong-Churl Suh, Eunyoung Kim
BACKGROUND: Influenza can cause cardiovascular abnormalities by inappropriately activating the coagulation cascade. Therefore, influenza vaccination is important because it decreases the risk of hospitalization for and mortality associated with heart disease. In particular, it reduces the occurrence of major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) patients. Our study aimed to estimate the disease burden of MACEs and its related direct and indirect costs in ACS patients...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28425985/the-cellular-senescence-of-leukemia-initiating-cells-from-acute-lymphoblastic-leukemia-is-postponed-by-%C3%AE-arrestin1-binding-with-p300-sp1-to-regulate-htert-transcription
#18
Shan Liu, Haiyan Liu, Ru Qin, Yi Shu, Zhidai Liu, Penghui Zhang, Caiwen Duan, Dengli Hong, Jie Yu, Lin Zou
Although we previously reported that the self-renewal of leukemia-initiating cells of B-lineage acute lymphoblastic leukemia (B-ALL LICs) was regulated by β-Arrestin1, a multiple-function protein, the cellular senescence is critical for LICs fate and leukemia progress, and worthy for further investigation. Here we found that depletion of β-Arrestin1 extended the population doubling time and the percentage of senile cells, the signatures of cellular senescence, of B-ALL LICs. Moreover, lack of β-Arrestin1 enhanced the expression of proteins (CBX, HIRA) and genes (P53, P16) related to senescence in leukemic Reh cells and B-ALL-LICs-derived leukemic mice...
April 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28423963/patient-perceptions-of-environmental-control-units-experiences-of-veterans-with-spinal-cord-injuries-and-disorders-receiving-inpatient-va-healthcare
#19
Bella Etingen, Rachael N Martinez, Marissa A Vallette, Ryan Dendinger, Balmatee Bidassie, Scott Miskevics, Hira T Khan, Huberta T Cozart, Sara M Locatelli, Frances M Weaver
PURPOSE: To assess patients' perceptions of environmental control units (ECUs) at Veterans Affairs Spinal Cord Injury Centers. MATERIALS AND METHODS: A brief questionnaire was conducted with patients in real-time while they were hospitalised ("on-the-spot questionnaire"); a survey was mailed to patients who had recently been discharged from a hospital stay ("discharge survey"). Data were analysed using descriptive statistics. RESULTS: Seventy on-the-spot questionnaires and 80 discharge surveys were collected...
April 19, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28412398/recent-update-on-nanoemulgel-as-topical-drug-delivery-system
#20
REVIEW
Hira Choudhury, Bapi Gorain, Manisha Pandey, Lipika Alok Chatterjee, Pinaki Sengupta, Arindam Das, Nagashekhara Molugulu, Prashant Kesharwani
Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption, and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and/or topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it...
April 12, 2017: Journal of Pharmaceutical Sciences
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