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Hira Choudhury, Bapi Gorain, Bappaditya Chatterjee, Uttam Kumar Mandal, Pinaki Sengupta, Rakesh Kumar Tekade
Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability. Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization...
December 1, 2016: Current Pharmaceutical Design
Aneta Nowakiewicz, Grażyna Ziółkowska, Aleksandra Trościańczyk, Przemysław Zięba, Sebastian Gnat
In this study, we analysed phenotypic resistance profiles and their reflection in the genomic profiles of Enterococcus spp. strains isolated from pigs raised on different farms. Samples were collected from five pig farms (n=90 animals) and tested for Enterococcus. Minimum inhibitory concentrations of 12 antimicrobials were determined using the broth microdilution method, and epidemiological molecular analysis of strains belonging to selected species (E. faecalis, E. faecium and E. hirae) was performed using the ADSRRS-fingerprinting method with a few modifications...
November 28, 2016: Journal of Medical Microbiology
Yuri Choi, In Ho Kwon, Jinwoo Jeong, Junyoung Chung, Younghoon Roh
OBJECTIVES: This study analyzed the incidence and characteristics of in-hospital cardiac arrest (IHCA) in Korea based on a sample group of patients that is representative of the population. METHODS: The incidence of IHCA in adults was extracted from HIRA-NIS-2009, a sample of all patients using medical services in Korea. IHCA patients were analyzed according to gender, age, type of medical institute, and classification under the 6th revision of the Korean Standard Classification of Diseases (KCD-6)...
October 2016: Healthcare Informatics Research
Zafar Neyaz, Hira Lal, Anuj Thakral, Alok Nath, Ram Naval Rao, Ritu Verma
CONTEXT: Percutaneous computed tomography (CT)-guided needle aspiration and biopsy technique have developed over time as a method for obtaining tissue specimen. Although this is a minimally invasive procedure, complications do occasionally occur. AIMS: The aim of the study was to evaluate the diagnostic yield and complications of 265 percutaneous CT-guided aspiration and biopsy procedures performed on various intrathoracic lesions. SETTINGS AND DESIGN: Data of percutaneous CT-guided aspiration and biopsy procedures of intrathoracic lesions performed over a 4 year period were retrospectively analyzed...
November 2016: Lung India: Official Organ of Indian Chest Society
Castigliano M Bhamidipati, Moses Mathur, Ravi S Hira, James M McCabe, Jay D Pal
No abstract text is available yet for this article.
November 17, 2016: JACC. Cardiovascular Interventions
Özlem Bilgiç, Hüseyin Hıra, Hilmi C Altınyazar, Pınar Karabağli
No abstract text is available yet for this article.
October 2016: Cutis; Cutaneous Medicine for the Practitioner
Priyank Yadav, Hira Lal, Pragati Verma, Chandan Mourya
No abstract text is available yet for this article.
November 21, 2016: BMJ Case Reports
M Daniel Ricketts, Ronen Marmorstein
Incorporation of variant histone sequences, in addition to post-translational modification of histones, serves to modulate the chromatin environment. Different histone chaperone proteins mediate the storage and chromatin deposition of variant histones. Although the two non-centromeric histone H3 variants, H3.1 and H3.3, differ by only 5 aa, replacement of histone H3.1 with H3.3 can modulate the transcription for highly expressed and developmentally required genes, lead to the formation of repressive heterochromatin, or aid in DNA and chromatin repair...
November 19, 2016: Journal of Molecular Biology
Hira Shafeeq, Anthony Vecchione, Celine DeMatteo
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Bablu Hira Mandal, Md Lutfor Rahman, Mashitah Mohd Yusoff, Kwok Feng Chong, Shaheen M Sarkar
Corn-cob cellulose supported poly(hydroxamic acid) Cu(II) complex was prepared by the surface modification of waste corn-cob cellulose through graft copolymerization and subsequent hydroximation. The complex was characterized by IR, UV, FESEM, TEM, XPS, EDX and ICP-AES analyses. The complex has been found to be an efficient catalyst for 1,3-dipolar Huisgen cycloaddition (CuAAC) of aryl/alkyl azides with a variety of alkynes as well as one-pot three-components reaction in the presence of sodium ascorbate to give the corresponding cycloaddition products in up to 96% yield and high turn over number (TON 18,600) and turn over frequency (TOF 930h(-1)) were achieved...
January 20, 2017: Carbohydrate Polymers
Priyank Yadav, Hira Lal
No abstract text is available yet for this article.
November 11, 2016: Abdominal Radiology
Nida Siddique, Hira Raza, Sehrish Ahmed, Zohaib Khurshid, Muhammad Sohail Zafar
Gene therapy holds a promising future for bridging the gap between the disciplines of medicine and clinical dentistry. The dynamic treatment approaches of gene therapy have been advancing by leaps and bounds. They are transforming the conventional approaches into more precise and preventive ones that may limit the need of using drugs and surgery. The oral cavity is one of the most accessible areas for the clinical applications of gene therapy for various oral tissues. The idea of genetic engineering has become more exciting due to its advantages over other treatment modalities...
November 10, 2016: Genes
Hankil Lee, Sung-Hee Oh, Hyeonseok Cho, Hyun-Jai Cho, Hye-Young Kang
BACKGROUND: Heart failure (HF) is one of the leading causes of morbidity and mortality in South Korea. With the rapidly aging population in the country, the prevalence of HF and its associated costs are expected to rise continuously. This study was carried out to estimate the prevalence and economic burden of HF in order to understand its impact on our society. METHODS: A prevalence-based, cost-of-illness study was conducted using the 2014 Health Insurance Review and Assessment Service-National Patients Sample (HIRA-NPS) data...
November 10, 2016: BMC Cardiovascular Disorders
Bapi Gorain, Hira Choudhury, Rakesh Kumar Tekade, Saumen Karan, P Jaisankar, Tapan Kumar Pal
Poor aqueous solubility and unfavourable de-esterification of olmesartan medoxomil (a selective angiotensin II receptor blocker), results in low oral bioavailability of less than 26%. Improvement of oral bioavailability with prolonged pharmacodynamics activity of olmesartan in Wistar rats had been approached by nanoemulsification strategy in our previous article [Colloid Surface B, 115, 2014: 286]. In continuation to that work, we herewith report the biodistribution behaviour and 28-day repeated dose sub-chronic toxicity of olmesartan medoxomil nanoemulsion in Wistar rats following oral administration...
December 2016: Regulatory Toxicology and Pharmacology: RTP
Gary A Abrams, Hira Jamal, William T Deeter, Nirav Patil
OBJECTIVES: Shear wave elastography (SWE) is an emerging technology that assesses hepatic fibrosis. The aim of our study was to determine the diagnostic accuracy of General Electric (GE) Healthcare's LOGIQ E9 SWE in patients with chronic hepatitis C virus using liver biopsy as the reference standard. METHODS: The liver stiffness of 43 subjects with hepatitis C virus was assessed using LOGIQ E9 SWE immediately before they underwent liver biopsy. The Fibrosis-4 Index (FIB-4) and Aspartate Aminotransferase-to-Platelet Index (APRI) were calculated, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined...
November 2016: Southern Medical Journal
Ali Bin Sarwar Zubairi, Hira Shahzad, Afia Zafar
OBJECTIVE: To assess the predisposing immunocompromised states, administration of pneumocystis jirovecii pneumonia prophylaxis, the disease course and outcomes of patients with pneumocystis jirovecii pneumonia. METHODS: The retrospective study was conducted at the Aga Khan University Hospital in Karachi. The medical records of patients diagnosed with pneumocystis jirovecii pneumonia from January 1995 to October 2015 were retrieved. Baseline characteristics, clinical course, treatment, and mortality rates were noted...
November 2016: JPMA. the Journal of the Pakistan Medical Association
Reshma Pandit, Kranti Khadilkar, Vijaya Sarathi, Rajeev Kasaliwal, Manjunath Goroshi, Shruti Khare, Sandhya Nair, Vijaya Raghavan, Abhay Dalvi, Priya Hira, Gwendolyn Fernandes, Pragati Sathe, Amey Rojekar, Gaurav Malhotra, Ganesh Bakshi, Gagan Prakash, Anil Bhansali, Rama Walia, Sadishkumar Kamalanathan, Jayaprakash Sahoo, Ankush Desai, Nikhil Bhagwat, Prashanth Mappa, Rajesh Rajput, Sudha Rao Chandrashekhar, Vyankatesh Shivane, Padma Menon, Anurag Lila, Tushar Bandgar, Nalin Shah
No abstract text is available yet for this article.
December 2016: European Journal of Endocrinology
Kano Suzuki, Kenji Mizutani, Shintaro Maruyama, Kazumi Shimono, Fabiana L Imai, Eiro Muneyuki, Yoshimi Kakinuma, Yoshiko Ishizuka-Katsura, Mikako Shirouzu, Shigeyuki Yokoyama, Ichiro Yamato, Takeshi Murata
V1-ATPases are highly conserved ATP-driven rotary molecular motors found in various membrane systems. We recently reported the crystal structures for the Enterococcus hirae A3B3DF (V1) complex, corresponding to the catalytic dwell state waiting for ATP hydrolysis. Here we present the crystal structures for two other dwell states obtained by soaking nucleotide-free V1 crystals in ADP. In the presence of 20 μM ADP, two ADP molecules bind to two of three binding sites and cooperatively induce conformational changes of the third site to an ATP-binding mode, corresponding to the ATP-binding dwell...
October 27, 2016: Nature Communications
Hira Burhan, Askari Syed Hasan, Syed Mansur-Ul-Haque, Ghazanfar Zaidi, Taha Shaikh, Aisha Zia
INTRODUCTION: According to the World Health Organization, the estimated number of malaria cases in Pakistan is about 1.5 million. Hematological variables like platelets, total leukocyte count (TLC), and hemoglobin (Hb) need to be evaluated to diagnose malaria in suspects. This study aimed to investigate the association between blood group and susceptibility to malaria and effects on platelets, TLC, and Hb. METHODOLOGY: This was a case-control study with a sample size of 446, of which 224 were malarial cases and 222 were controls...
October 31, 2016: Journal of Infection in Developing Countries
Sun Hyo Park
BACKGROUND: Chronic lung diseases may have an influence on pulmonary vessel walls as well as on pulmonary haemodynamics. However, there is limited data on the occurrence of pulmonary embolism (PE) and deep vein thrombosis (DVT) in patients with chronic lung diseases, which have the potential to contribute to the development of pulmonary vascular abnormalities. We aimed to explore the prevalence of PE and DVT in patients with COPD and ILD. METHODS: We evaluated the venous thromboembolism prevalence associated with COPD and ILD using Korean Health Insurance Review and Assessment Service (HIRA) data from January 2011 to December 2011...
2016: SpringerPlus
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