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https://www.readbyqxmd.com/read/27798455/the-gut-microbiome-and-hypertension
#1
Meirav Pevsner-Fischer, Eran Blacher, Evgeny Tatirovsky, Iddo Z Ben-Dov, Eran Elinav
PURPOSE OF REVIEW: The mammalian mucosal surfaces are densely inhabited by a diverse microbial ecosystem termed the microbiota. Among these highly heterogeneous populations, the largest and richest is the gut microbiota, recently suggested to affect various physiological traits and susceptibility to disease. Novel metagenomic and metabolomic approaches, which have been developed in the past decade, have enabled the elucidation of the contribution of the microbiota to metabolic, immunologic, neurologic and endocrine homeostasis...
January 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27787408/chronic-psychosocial-stress-and-gut-health-in-children-associations-with-calprotectin-and-fecal-short-chain-fatty-acids
#2
Nathalie Michels, Tom Van de Wiele, Stefaan De Henauw
OBJECTIVES: The mechanisms underpinning the association between chronic stress and gut health are poorly understood. We aimed to investigate the relationship between bacterial produced short-chain fatty acids, gut barrier function, and stress measures. METHODS: A fecal sample, hair sample, and questionnaire data were collected from 113 Belgian children (8-16 years old). Biological measures of stress included hair cortisol (most proximal 3 cm) and 5-minute heart rate variability (high frequency)...
October 26, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27754287/br-07-2-the-linking-in-the-human-observational-and-clinical-study
#3
Peter Nilsson
A number of chronic disease conditions tend to cluster in families with an increased risk in first-degree relatives, but also an increased risk in second-degree relatives. This fact is most often referred to as the heritability (heredity) of these diseases and explained by the influence of genetic factors, or shared environment, even if the more specific details or mechanism leading to disease are not known. New methods have to be explored in screening studies and register linkage studies to define and measure consequences of a positive family history of disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27743978/influence-of-maternal-obesity-on-the-long-term-health-of-offspring
#4
Keith M Godfrey, Rebecca M Reynolds, Susan L Prescott, Moffat Nyirenda, Vincent W V Jaddoe, Johan G Eriksson, Birit F P Broekman
In addition to immediate implications for pregnancy complications, increasing evidence implicates maternal obesity as a major determinant of offspring health during childhood and later adult life. Observational studies provide evidence for effects of maternal obesity on her offspring's risks of obesity, coronary heart disease, stroke, type 2 diabetes, and asthma. Maternal obesity could also lead to poorer cognitive performance and increased risk of neurodevelopmental disorders, including cerebral palsy. Preliminary evidence suggests potential implications for immune and infectious-disease-related outcomes...
October 10, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27687914/comparing-the-survivability-of-lactobacillus-species-in-various-probiotic-delivery-vehicles
#5
Derek Fleming, Jennifer Kesey, Kendra Rumbaugh, Sharmila Dissanaike
BACKGROUND: Probiotics are widely used in healthy and nonhealthy individuals to maintain a favorable gut microbiome and inhibit pathogen takeover. Currently, there are many varieties of probiotic delivery vehicles on the market, with no real research indicating which is the most effective at allowing for colon colonization. In this study, we sought to determine if probiotic preparation influences the ability of Lactobacillus species, one of the most common genera of probiotic bacteria, to survive gastric acidity...
September 29, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27677687/where-genes-meet-environment-integrating-the-role-of-gut-luminal-contents-immunity-and-pancreas-in-type-1-diabetes
#6
Fraser W Scott, Lynley Pound, Christopher Patrick, Chandra Eberhard, Jennifer Crookshank
The rise in new cases of type 1 diabetes (T1D) in genetically susceptible individuals over the past half century has been attributed to numerous environmental "triggers" or promoters such as enteroviruses, diet, and most recently, gut bacteria. No single cause has been identified in humans, likely because there are several pathways by which one can develop T1D. There is renewed attention to the role of the gut and its immune system in T1D pathogenesis based largely on recent animal studies demonstrating that altering the gut microbiota affects diabetes incidence...
September 13, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27643285/br-07-2-the-linking-in-the-human-observational-and-clinical-study
#7
Peter Nilsson
A number of chronic disease conditions tend to cluster in families with an increased risk in first-degree relatives, but also an increased risk in second-degree relatives. This fact is most often referred to as the heritability (heredity) of these diseases and explained by the influence of genetic factors, or shared environment, even if the more specific details or mechanism leading to disease are not known. New methods have to be explored in screening studies and register linkage studies to define and measure consequences of a positive family history of disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27641779/contemporary-issues-regarding-nutrition-in-cardiovascular-rehabilitation
#8
Sébastien Lacroix, Jennifer Cantin, Anil Nigam
In this article, we discuss certain contemporary and controversial topics in cardiovascular (CV) nutrition including recent data regarding the health benefits of the Mediterranean diet, the role of saturated fatty acids, red meat and the microbiome in CV disease and the current role of personalized CV nutrition. Findings from the PREDIMED study now demonstrate the health benefits of the Mediterranean diet even in the absence of heart disease. The study highlighted that even small, sustained and easily implementable changes to diet can provide significant health benefits even in Mediterranean regions...
September 15, 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27515213/vitamin-d-deficiency-changes-the-intestinal-microbiome-reducing-b-vitamin-production-in-the-gut-the-resulting-lack-of-pantothenic-acid-adversely-affects-the-immune-system-producing-a-pro-inflammatory-state-associated-with-atherosclerosis-and-autoimmunity
#9
S C Gominak
STUDY OBJECTIVES: Vitamin D blood levels of 60-80ng/ml promote normal sleep. The present study was undertaken to explore why this beneficial effect waned after 2years as arthritic pain increased. Pantothenic acid becomes coenzyme A, a cofactor necessary for cortisol and acetylcholine production. 1950s experiments suggested a connection between pantothenic acid deficiency, autoimmune arthritis and insomnia. The B vitamins have been shown to have an intestinal bacterial source and a food source, suggesting that the normal intestinal microbiome may have always been the primary source of B vitamins...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27507222/gut-microbiome-associates-with-lifetime-cardiovascular-disease-risk-profile-among-bogalusa-heart-study-participants
#10
Tanika N Kelly, Lydia A Bazzano, Nadim J Ajami, Hua He, Jinying Zhao, Joseph F Petrosino, Adolfo Correa, Jiang He
RATIONALE: Few studies have systematically assessed the influence of gut microbiota on cardiovascular disease (CVD) risk. OBJECTIVE: To examine the association between gut microbiota and lifetime CVD risk profile among 55 Bogalusa Heart Study participants with the highest and 57 with the lowest lifetime burdens of CVD risk factors. METHODS AND RESULTS: 16S ribosomal RNA sequencing was conducted on microbial DNA extracted from stool samples of the Bogalusa Heart Study participants...
September 30, 2016: Circulation Research
https://www.readbyqxmd.com/read/27390783/experimental-periodontitis-results-in-prediabetes-and-metabolic-alterations-in-brain-liver-and-heart-global-untargeted-metabolomic-analyses
#11
Vladimir Ilievski, Jason M Kinchen, Ramya Prabhu, Fadi Rim, Lara Leoni, Terry G Unterman, Keiko Watanabe
Results from epidemiological studies suggest that there is an association between periodontitis and prediabetes, however, causality is not known. The results from our previous studies suggest that induction of periodontitis leads to hyperinsulinemia glucose intolerance and insulin resistance, all hallmarks of prediabetes. However, global effects of periodontitis on critical organs in terms of metabolic alterations are unknown. We determined the metabolic effects of periodontitis on brain, liver, heart and plasma resulting from Porphyromonas gingivalis induced periodontitis in mice...
2016: Journal of Oral Biology
https://www.readbyqxmd.com/read/27377678/trimethylamine-n-oxide-tmao-response-to-animal-source-foods-varies-among-healthy-young-men-and-is-influenced-by-their-gut-microbiota-composition-a-randomized-controlled-trial
#12
Clara E Cho, Siraphat Taesuwan, Olga V Malysheva, Erica Bender, Nathan F Tulchinsky, Jian Yan, Jessica L Sutter, Marie A Caudill
SCOPE: Trimethylamine-N-oxide (TMAO), a metabolite linked to the gut microbiota, is associated with excess risk of heart disease. We hypothesized that (i) TMAO response to animal source foods would vary among healthy men and (ii) this response would be modified by their gut microbiome. METHODS AND RESULTS: A crossover feeding trial in healthy young men (n = 40) was conducted with meals containing TMAO (fish), its dietary precursors, choline (eggs) and carnitine (beef), and a fruit control...
July 5, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27341799/research-on-the-human-virome-where-are-we-and-what-is-next
#13
Shimian Zou, Lis Caler, Sandra Colombini-Hatch, Simone Glynn, Pothur Srinivas
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened a Working Group on the Microbiome in Cardiovascular, Pulmonary and Hematologic Health and Diseases from June 25, 2014, to June 26, 2014. The Working Group's central goal was to define what major microbiome research areas warranted additional study in the context of heart, lung, and blood (HLB) diseases. The Working Group identified studies of the human virome a key priority.
2016: Microbiome
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#14
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27279859/colonization-of-multidrug-resistant-pathogens-in-a-hybrid-pediatric-cardiac-surgery-center
#15
Radoslaw Jaworski, Ireneusz Haponiuk, Mariusz Steffens, Elzbieta Arlukowicz, Ninela Irga-Jaworska, Maciej Chojnicki, Ewelina Kwasniak, Jacek Zielinski
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA)...
June 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27250856/genomic-resources-and-draft-assemblies-of-the-human-and-porcine-varieties-of-scabies-mites-sarcoptes-scabiei-var-hominis-and-var-suis
#16
Ehtesham Mofiz, Deborah C Holt, Torsten Seemann, Bart J Currie, Katja Fischer, Anthony T Papenfuss
BACKGROUND: The scabies mite, Sarcoptes scabiei, is a parasitic arachnid and cause of the infectious skin disease scabies in humans and mange in other animal species. Scabies infections are a major health problem, particularly in remote Indigenous communities in Australia, where secondary group A streptococcal and Staphylococcus aureus infections of scabies sores are thought to drive the high rate of rheumatic heart disease and chronic kidney disease. RESULTS: We sequenced the genome of two samples of Sarcoptes scabiei var...
2016: GigaScience
https://www.readbyqxmd.com/read/27118445/impact-of-dietary-nitrate-on-age-related-diastolic-dysfunction
#17
Christos Rammos, Ulrike B Hendgen-Cotta, Matthias Totzeck, Julia Pohl, Peter Lüdike, Ulrich Flögel, René Deenen, Karl Köhrer, Brent A French, Axel Gödecke, Malte Kelm, Tienush Rassaf
AIMS: Diastolic dysfunction is highly prevalent, and ageing is the main contributor due to impairments in active cardiac relaxation, ventriculo-vascular stiffening, and endothelial dysfunction. Nitric oxide (NO) affects cardiovascular functions, and NO bioavailability is critically reduced with ageing. Whether replenishment of NO deficiency with dietary inorganic nitrate would offer a novel approach to reverse age-related cardiovascular alterations was not known. METHODS AND RESULTS: A dietary nitrate supplementation was applied to young (6 month) and old (20 month) wild-type mice for 8 weeks and compared with controls...
June 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27099397/the-hybrid-mouse-diversity-panel-a-resource-for-systems-genetics-analyses-of-metabolic-and-cardiovascular-traits
#18
Aldons J Lusis, Marcus M Seldin, Hooman Allayee, Brian J Bennett, Mete Civelek, Richard C Davis, Eleazar Eskin, Charles R Farber, Simon Hui, Margarete Mehrabian, Frode Norheim, Calvin Pan, Brian Parks, Christoph D Rau, Desmond J Smith, Thomas Vallim, Yibin Wang, Jessica Wang
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated...
June 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27095829/nutrigenomics-the-microbiome-and-gene-environment-interactions-new-directions-in-cardiovascular-disease-research-prevention-and-treatment-a-scientific-statement-from-the-american-heart-association
#19
Jane F Ferguson, Hooman Allayee, Robert E Gerszten, Folami Ideraabdullah, Penny M Kris-Etherton, José M Ordovás, Eric B Rimm, Thomas J Wang, Brian J Bennett
Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome...
June 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/26951682/deciphering-ocean-carbon-in-a-changing-world
#20
Mary Ann Moran, Elizabeth B Kujawinski, Aron Stubbins, Rob Fatland, Lihini I Aluwihare, Alison Buchan, Byron C Crump, Pieter C Dorrestein, Sonya T Dyhrman, Nancy J Hess, Bill Howe, Krista Longnecker, Patricia M Medeiros, Jutta Niggemann, Ingrid Obernosterer, Daniel J Repeta, Jacob R Waldbauer
Dissolved organic matter (DOM) in the oceans is one of the largest pools of reduced carbon on Earth, comparable in size to the atmospheric CO2 reservoir. A vast number of compounds are present in DOM, and they play important roles in all major element cycles, contribute to the storage of atmospheric CO2 in the ocean, support marine ecosystems, and facilitate interactions between organisms. At the heart of the DOM cycle lie molecular-level relationships between the individual compounds in DOM and the members of the ocean microbiome that produce and consume them...
March 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
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