keyword
https://read.qxmd.com/read/38534735/microbial-based-bioactive-compounds-to-alleviate-inflammation-in-obesity
#1
REVIEW
Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor
The increased prevalence of obesity with several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has reached global pandemic proportions. Lifestyle changes may result in a persistent positive energy balance, hastening the onset of these age-related disorders and consequently leading to a diminished lifespan. Although suggestions have been raised on the possible link between obesity and the gut microbiota, progress has been hampered due to the extensive diversity and complexities of the gut microbiota...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38526201/gut-derived-exosomes-mediate-the-microbiota-dysbiosis-induced-spermatogenesis-impairment-by-targeting-meioc-in-mice
#2
JOURNAL ARTICLE
Tong Chen, Boqi Zhang, Guitian He, Nan Wang, Maosheng Cao, Caomeihui Shen, Xue Chen, Lu Chen, Kening Liu, Yuxin Luo, Yiqiu Huang, Chenfeng Yuan, Xu Zhou, Chunjin Li
Diseases like obesity and intestinal inflammation diseases are accompanied by dysbiosis of the gut microbiota (DSGM), which leads to various complications, including systemic metabolic disorders. DSGM reportedly impairs the fertility of male mice; however, the regulatory mechanism is unclear. Exosomes are molecular mediators of intercellular communication, but the regulation of spermatogenesis by non-reproductive tissue-originated exosomes remains unknown. The present study shows that DSGM altered the miRNA expression profile of mouse circulating exosomes and impaired spermatogenesis...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38522315/polyphenols-from-hickory-nut-reduce-the-occurrence-of-atherosclerosis-in-mice-by-improving-intestinal-microbiota-and-inhibiting-trimethylamine-n-oxide-production
#3
JOURNAL ARTICLE
Chenyu Jiang, Song Wang, Yihan Wang, Ketao Wang, Chunying Huang, Fei Gao, Huang Peng Hu, Yangyong Deng, Wen Zhang, Jian Zheng, Jianqin Huang, Yan Li
BACKGROUND: Trimethylamine N-oxide (TMAO), a metabolite produced by intestinal microbiota through metabolizing phosphatidylcholine, choline, l-carnitine and betaine in the diet, has been implicated in the pathogenesis of atherosclerosis (AS). Concurrently, dietary polyphenols have garnered attention for their potential to ameliorate obesity, diabetes and atherosclerosis primarily by modulating the intestinal microbial structure. Hickory (Carya cathayensis) nut, a polyphenol-rich food product favored for its palatability, emerges as a candidate for exploration...
January 9, 2024: Phytomedicine
https://read.qxmd.com/read/38519181/prebiotics-modulate-the-microbiota-gut-brain-axis-and-ameliorate-anxiety-and-depression-like-behavior-in-hfd-fed-mice
#4
JOURNAL ARTICLE
Igor Henrique Rodrigues de Paiva, Laís Macedo Maciel, Rodrigo Soares da Silva, Ingrid Prata Mendonça, José Roberto Botelho de Souza, Christina Alves Peixoto
Previous research has demonstrated that Prebiotics can influence the composition of the gut microbiota, consequently impacting mood regulation. This study aimed to assess the effects of Prebiotics, specifically Fructooligosaccharides (FOS) and Galactooligosaccharides (GOS) on neuroinflammation, depression, and anxiety-like behavior in a mouse model fed a high-fat diet (HFD). Initially, mice were divided into two groups: a control group on a standard diet (n = 15) and a group on an HFD for 18 weeks (n = 45)...
April 2024: Food Research International
https://read.qxmd.com/read/38514921/high-fat-diet-induced-obesity-causes-intestinal-th17-treg-imbalance-that-impairs-the-intestinal-barrier-and-aggravates-anxiety-like-behavior-in-mice
#5
JOURNAL ARTICLE
Yao Cai, Wenlin Deng, Qiuping Yang, Guixian Pan, Zao Liang, Ximei Yang, Sitao Li, Xin Xiao
The prevalence of autism spectrum disorders (ASD) has been steadily increasing, and growing evidence suggests a link between high-fat diet (HFD), obesity, and ASD; however, the mechanism underlying this association remains elusive. Herein, BTBR T + tf/J (BTBR) inbred mice (a mouse ASD model) and C57Bl/6J (C57) mice were fed an HFD and normal diet (ND) for 8 weeks (groups: C57 + ND, C57 + HFD, BTBR + ND, and BTBR + HFD). Subsequently, mice underwent behavioral assessments, followed by intestinal tissues harvesting to detect expression of intestinal barrier proteins and inflammatory factors and immune cell numbers, and a correlation analysis...
March 30, 2024: International Immunopharmacology
https://read.qxmd.com/read/38512763/breaking-the-barriers-the-role-of-gut-homeostasis-in-metabolic-associated-steatotic-liver-disease-masld
#6
REVIEW
Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A Nevzorova
Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease (NAFLD), a growing health concern. The complex progression of MASLD extends beyond the liver, driven by "gut-liver axis," where diet, genetics, and gut-liver interactions influence disease development. The pathophysiology of MASLD involves excessive liver fat accumulation, hepatocyte dysfunction, inflammation, and fibrosis, with subsequent risk of hepatocellular carcinoma (HCC)...
2024: Gut Microbes
https://read.qxmd.com/read/38501861/exploring-functional-genes-correlation-with-s-equol-concentration-and-new-daidzein-racemase-identification
#7
JOURNAL ARTICLE
Yun-Fei Hu, Shu Luo, Sheng-Qi Wang, Ke-Xin Chen, Wei-Xuan Zhong, Bai-Yuan Li, Lin-Yan Cao, Hua-Hai Chen, Ye-Shi Yin
UNLABELLED: With its estrogenic activity, ( S )-equol plays an important role in maintaining host health and preventing estrogen-related diseases. Exclusive production occurs through the transformation of soy isoflavones by intestinal bacteria, but the reasons for variations in ( S )-equol production among different individuals and species remain unclear. Here, fecal samples from humans, pigs, chickens, mice, and rats were used as research objects. The concentrations of ( S )-equol, along with the genetic homology and evolutionary relationships of ( S )-equol production-related genes [daidzein reductase (DZNR), daidzein racemase (DDRC), dihydrodaidzein reductase (DHDR), tetrahydrodaidzein reductase (THDR)], were analyzed...
March 20, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38494694/large-yellow-tea-polysaccharide-alleviates-hfd-induced-intestinal-homeostasis-dysbiosis-via-modulating-gut-barrier-integrity-immune-responses-and-the-gut-microbiome
#8
JOURNAL ARTICLE
Yan Ma, Hai Xie, Na Xu, Minni Li, Lan Wang, Huifang Ge, Zhongwen Xie, Daxiang Li, Hongyan Wang
Long-term high-fat diet (HFD) will induce dysbiosis and a disturbance of intestinal homeostasis. Large yellow tea polysaccharide (LYP) has been shown to improve obesity-associated metabolic disease via modulation of the M2 polarization. However, the contribution of LYP to intestinal barrier impairment and improvement mechanisms in obesity caused by an HFD are still not clear. In this study, we evaluated the impacts of LYP on the mucosal barrier function and microbiota composition in HFD-feeding mice. Results exhibited that dietary LYP supplement could ameliorate the physical barrier function via maintaining intestinal mucosal integrity and elevating tight-junction protein production, strengthen the chemical barrier function via up-regulating the levels of glucagon-like peptide-1 and increasing mucin-producing goblet cell numbers, and enhance the intestinal immune barrier function though suppressing immune cell subsets and cytokines toward pro-inflammatory phenotypes...
March 17, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38493812/irisin-delays-the-onset-of-type-1-diabetes-in-nod-mice-by-enhancing-intestinal-barrier
#9
JOURNAL ARTICLE
Yujing Sun, Yilin Wang, Ziang Lin, Fuhua Zhang, Yan Zhang, Tongxin Ren, LiNa Wang, Qincheng Qiao, Mengyang Shen, Juncheng Wang, Youchen Song, Yu Sun, Peng Lin
Type 1 diabetes (T1D), a complex autoimmune disease, is intricately linked to the gut's epithelial barrier function. Emerging evidence emphasizes the role of irisin, an exercise-related hormone, in preserving intestinal integrity. This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38486768/antiobesity-and-antidiabetes-effects-of-cyperus-rotundus-rhizomes-presenting-protein-tyrosine-phosphatase-dipeptidyl-peptidase-4-metabolic-enzymes-stress-oxidant-and-inflammation-inhibitory-potential
#10
JOURNAL ARTICLE
Faiza I A Abdella, Amani Toumi, Sarra Boudriga, Tahani Y A Alanazi, Asma K Alshamari, Ahlam Abdulrahman Alrashdi, Khaled Hamden
Diabetes is a significant global health concern that increases the vulnerability to various chronic illnesses. In view of this issue, the current research aimed to examine the effects of administering an extract derived from the tubers of Cyperus rotundus L (CrE) on obesity, type 1 diabetes, and liver-kidney toxicity. Through the utilization of HPLC-DAD analysis, it was discovered that the extract contained several components, including quercetin (47.8%), luteolin glucoside (17%), luteolin (7.56%), apigenin-7-glucoside (6...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38430822/a-green-tea-extract-confection-decreases-circulating-endotoxin-and-fasting-glucose-by-improving-gut-barrier-function-but-without-affecting-systemic-inflammation-a-double-blind-placebo-controlled-randomized-trial-in-healthy-adults-and-adults-with-metabolic-syndrome
#11
JOURNAL ARTICLE
Min Zeng, Joanna K Hodges, Avinash Pokala, Mona Khalafi, Geoffrey Y Sasaki, Jillian Pierson, Sisi Cao, Guy Brock, Zhongtang Yu, Jiangjiang Zhu, Yael Vodovotz, Richard S Bruno
Anti-inflammatory activities of catechin-rich green tea extract (GTE) in obese rodents protect against metabolic endotoxemia by decreasing intestinal permeability and absorption of gut-derived endotoxin. However, translation to human health has not been established. We hypothesized that GTE would reduce endotoxemia by decreasing gut permeability and intestinal and systemic inflammation in persons with metabolic syndrome (MetS) compared with healthy persons. A randomized, double-blind, placebo-controlled, crossover trial in healthy adults (n = 19, 34 ± 2 years) and adults with MetS (n = 21, 40 ± 3 years) examined 4-week administration of a decaffeinated GTE confection (890 mg/d total catechins) on serum endotoxin, intestinal permeability, gut and systemic inflammation, and cardiometabolic parameters...
February 5, 2024: Nutrition Research
https://read.qxmd.com/read/38417203/fecal-microbiota-transplantation-ameliorates-abdominal-obesity-through-inhibiting-microbiota-mediated-intestinal-barrier-damage-and-inflammation-in-mice
#12
JOURNAL ARTICLE
Xiaoqiang Zhu, Lijun Zhao, Liang Lei, Yanhong Zhu, Jun Xu, Li Liu
Abdominal obesity (AO), characterized by the excessive abdominal fat accumulation, has emerged as a significant public health concern due to its metabolic complications and escalating prevalence worldwide, posing a more pronounced threat to human health than general obesity. While certain studies have indicated that intestinal flora contributed to diet-induced general obesity, the precise involvement of gut microbiota in the development of AO, specifically the accumulation of abdominal fat, remains inadequately explored...
February 20, 2024: Microbiological Research
https://read.qxmd.com/read/38412940/intestinal-heat-shock-proteins-in-metabolic-syndrome-novel-mediators-of-obesity-and-its-comorbidities-resolution-after-metabolic-surgery
#13
REVIEW
Giulia Angelini, Sara Russo, Geltrude Mingrone
Over the past 40 years, the prevalence of obesity has risen dramatically, reaching epidemic proportions. Metabolic surgery has proven to be highly effective in treating obesity, leading to significant improvements or complete resolution of obesity-related comorbidities. Research conducted in both animals and humans suggests that the metabolic benefits achieved through metabolic surgery cannot be solely attributed to weight loss. Indeed, there has been an increasing recognition of intestinal inflammation as a novel factor influencing obesity...
February 25, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38409604/resistant-starch-intake-facilitates-weight-loss-in-humans-by-reshaping-the-gut-microbiota
#14
JOURNAL ARTICLE
Huating Li, Lei Zhang, Jun Li, Qian Wu, Lingling Qian, Junsheng He, Yueqiong Ni, Petia Kovatcheva-Datchary, Rui Yuan, Shuangbo Liu, Li Shen, Mingliang Zhang, Bin Sheng, Ping Li, Kang Kang, Liang Wu, Qichen Fang, Xiaoxue Long, Xiaolin Wang, Yanli Li, Yaorui Ye, Jianping Ye, Yuqian Bao, Yueliang Zhao, Guowang Xu, Xinyu Liu, Gianni Panagiotou, Aimin Xu, Weiping Jia
Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean -2.8 kg) and improve insulin resistance in individuals with excess body weight...
February 26, 2024: Nature metabolism
https://read.qxmd.com/read/38400571/isolation-of-lactobacillus-acidophilus-strain-and-its-anti-obesity-effect-in-a-diet-induced-obese-murine-model
#15
JOURNAL ARTICLE
Yanyi Zheng, Silu Zhang, Zhizhu Zhang, Tengxun Zhang, Xin Teng, Guoxun Xiao, Song Huang
Intestinal microbiota is a potential determinant of obesity, with probiotic bile salt hydrolase (BSH) as one of the key mechanisms in the anti-obesity effects. In this study, we present a Lactobacillus acidophilus GOLDGUT-LA100 (LA100) with high BSH activity, good gastric acid and bile salt tolerance and potential anti-obesity effect. LA100's anti-obesity effects were evaluated in a high-fat diet-induced, obese mouse model. LA100 administration alleviates high-fat diet-induced pathophysiological symptoms, such as body weight gain, high serum glucose and cholesterol level, hepatic lipid accumulation, and adipose inflammation...
February 23, 2024: Letters in Applied Microbiology
https://read.qxmd.com/read/38399722/intestinal-effects-of-filtered-alkalinized-water-in-lean-and-obese-zucker-rats
#16
JOURNAL ARTICLE
Laura Doblado, Ligia Esperanza Díaz, Esther Nova, Ascensión Marcos, María Monsalve
This study evaluated the intestinal effects of alkalinized filtered water in lean and obese adult Zucker rats. For 3 months, 12-week-old rats consumed either tap water or filtered alkalinized tap water from Madrid city. Weight gain was monitored, changes in metabolism were evaluated by indirect calorimetry, and total antioxidant capacity and levels of inflammatory mediators were measured in plasma. Feces were collected, their microbial composition was analyzed and histological analysis of the small and large intestine was performed, assessing the general state of the mucosa (MUC2), the inflammatory state (F4/80) and the presence of oxidative modifications in protein 4-Hydroxynonenal (4-HNE) by immunofluorescence (IF) and immunohistochemistry (IHC)...
February 2, 2024: Microorganisms
https://read.qxmd.com/read/38398873/between-dysbiosis-maternal-immune-activation-and-autism-is-there-a-common-pathway
#17
REVIEW
Maria Suprunowicz, Natalia Tomaszek, Agata Urbaniak, Klaudia Zackiewicz, Stefan Modzelewski, Napoleon Waszkiewicz
Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut-brain-microbiome axis in the pathogenesis of ASD. Research indicates an abnormal composition of the gut microbiome and the potential involvement of bacterial molecules in neuroinflammation and brain development disruptions. Concurrently, attention is directed towards the role of short-chain fatty acids (SCFAs) and impaired intestinal tightness...
February 16, 2024: Nutrients
https://read.qxmd.com/read/38397726/the-association-between-functional-dyspepsia-and-metabolic-syndrome-the-state-of-the-art
#18
REVIEW
Mile Volarić, Dunja Šojat, Ljiljana Trtica Majnarić, Domagoj Vučić
Functional dyspepsia is a common functional disorder of the gastrointestinal tract that is responsible for many primary care visits. No organic changes have been found to explain its symptoms. We hypothesize that modern lifestyles and environmental factors, especially psychological stress, play a crucial role in the high prevalence of functional dyspepsia and metabolic syndrome. While gastrointestinal tract diseases are rarely linked to metabolic disorders, chronic stress, obesity-related metabolic syndrome, chronic inflammation, intestinal dysbiosis, and functional dyspepsia have significant pathophysiological associations...
February 18, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38396547/supplementation-with-silybum-marianum-extract-synbiotics-omega-3-fatty-acids-vitamins-and-minerals-impact-on-biochemical-markers-and-fecal-microbiome-in-overweight-dogs
#19
JOURNAL ARTICLE
Fatemeh Balouei, Bruno Stefanon, Elisa Martello, David Atuahene, Misa Sandri, Giorgia Meineri
Overweight and obese dogs can develop metabolic dysfunction, characterized by an inflammatory response and involvement of liver functions. If a modulation of the gut microbiome and its interaction with the gut-liver axis is implicated in the development of metabolic dysfunction, exploration becomes necessary. Over the past decade, diverse therapeutic approaches have emerged to target pathogenic factors involved in metabolic dysfunction. This study investigated the impact of a supplement with hepatoprotective activity, containing extracts of Silybum marianum , prebiotics, probiotics, n-3 polyunsaturated fatty acids, vitamins, and minerals on hematological markers of liver functions and inflammation, as well as on the intestinal microbiota of 10 overweight adult dogs over a 35-day time span...
February 9, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38383607/intestinal-il-22ra1-signaling-regulates-intrinsic-and-systemic-lipid-and-glucose-metabolism-to-alleviate-obesity-associated-disorders
#20
JOURNAL ARTICLE
Stephen J Gaudino, Ankita Singh, Huakang Huang, Jyothi Padiadpu, Makheni Jean-Pierre, Cody Kempen, Tej Bahadur, Kiyoshi Shiomitsu, Richard Blumberg, Kenneth R Shroyer, Semir Beyaz, Natalia Shulzhenko, Andrey Morgun, Pawan Kumar
IL-22 is critical for ameliorating obesity-induced metabolic disorders. However, it is unknown where IL-22 acts to mediate these outcomes. Here we examine the importance of tissue-specific IL-22RA1 signaling in mediating long-term high fat diet (HFD) driven metabolic disorders. To do so, we generated intestinal epithelium-, liver-, and white adipose tissue (WAT)-specific Il22ra1 knockout and littermate control mice. Intestinal epithelium- and liver-specific IL-22RA1 signaling upregulated systemic glucose metabolism...
February 21, 2024: Nature Communications
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