keyword
MENU ▼
Read by QxMD icon Read
search

Digestive disorder

keyword
https://www.readbyqxmd.com/read/29689371/large-supramolecular-structures-of-33-mer-gliadin-peptide-activate-toll-like-receptors-in-macrophages
#1
M G Herrera, M Pizzuto, C Lonez, K Rott, A Hütten, N Sewald, J-M Ruysschaert, V I Dodero
Gliadin, an immunogenic protein present in wheat, is not fully degraded by humans and after the normal gastric and pancreatic digestion, the immunodominant 33-mer gliadin peptide remains unprocessed. The 33-mer gliadin peptide is found in human faeces and urine, proving not only its proteolytic resistance in vivo but more importantly its transport through the entire human body. Here, we demonstrate that 33-mer supramolecular structures larger than 220nm induce the overexpression of nuclear factor kappa B (NF-κB) via a specific Toll-like Receptor (TLR) 2 and (TLR) 4 dependent pathway and the secretion of pro-inflammatory cytokines such as IP-10/CXCL10 and TNF-α...
April 21, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29686654/high-fat-diet-induces-dysbiosis-of-gastric-microbiota-prior-to-gut-microbiota-in-association-with-metabolic-disorders-in-mice
#2
Cong He, Dandan Cheng, Chao Peng, Yanshu Li, Yin Zhu, Nonghua Lu
Accumulating evidence suggests that high-fat diet (HFD) induced metabolic disorders are associated with dysbiosis of gut microbiota. However, no study has explored the effect of HFD on the gastric microbiota. This study established the HFD animal model to determine the impact of HFD on the gastric microbiota and its relationship with the alterations of gut microbiota. A total of 40 male C57BL/6 mice were randomly allocated to receive a standard chow diet (CD) or HFD for 12 weeks (12CD group and 12HFD group) and 24 weeks (24CD group and 24HFD group) ( n = 10 mice per group)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674600/incidence-and-comorbidity-of-reactive-attachment-disorder-based-on-national-health-insurance-claims-data-2010-2012-in-korea
#3
Minha Hong, Duk Soo Moon, Hyejung Chang, Seung Yup Lee, Seong Woo Cho, Kyung-Sook Lee, Jin-Ah Park, Sang Min Lee, Geon Ho Bahn
Objective: We aimed to investigate the current diagnostic incidence and medical and psychiatric comorbidities of reactive attachment disorder (RAD) using the National Health Insurance Review and Assessment (HIRA) claims data. Methods: To examine the diagnostic incidence, we selected patients who were under 10-year-old and had at least one medical claim containing a 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) code for RAD (F94...
April 20, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29674278/cassia-grandis-fruit-extract-reduces-the-blood-glucose-level-in-alloxan-induced-diabetic-rats
#4
Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Hady Keita, Edgar Puente Zapata, Helison Carvalho, Emersom Silva Lima, Tatiane Pereira de Sousa, José Carlos Tavares Carvalho
INTRODUCTION: Cassia grandis Lf fruits are ethnobotanically used for digestive disorders, anemia, and for reducing blood glucose. However, there are no studies about the antidiabetic activity nor the oral toxicity of the plant fruit-extracts. This paper aims to evaluate the hypoglycemic effect of C. grandis fruits extract in vivo, and assess the acute oral toxicity, and sub-acute oral toxicity. The antioxidant activity and the α-glycosidase inhibitor effect were also evaluated. METHODS: The extract was obtained by maceration of the fruit pulp with 70% hydroalcoholic solution (1:2, m:v)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29673211/the-role-of-gut-microbiota-in-obesity-and-type-2-and-type-1-diabetes-mellitus-new-insights-into-old-diseases
#5
REVIEW
Igor Alexander Harsch, Peter Christopher Konturek
The investigation of the human microbiome is the most rapidly expanding field in biomedicine. Early studies were undertaken to better understand the role of microbiota in carbohydrate digestion and utilization. These processes include polysaccharide degradation, glycan transport, glycolysis, and short-chain fatty acid production. Recent research has demonstrated that the intricate axis between gut microbiota and the host metabolism is much more complex. Gut microbiota—depending on their composition—have disease-promoting effects but can also possess protective properties...
April 17, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29670566/non-motor-symptoms-of-parkinson-s-disease-and-their-impact-on-quality-of-life-in-a-cohort-of-moroccan-patients
#6
Houyam Tibar, Khalil El Bayad, Ahmed Bouhouche, El Hachmia Ait Ben Haddou, Ali Benomar, Mohamed Yahyaoui, Abdelhamid Benazzouz, Wafa Regragui
Background: Non-motor symptoms (NMSs) are a real burden in Parkinson's disease (PD). They may appear in early pre-symptomatic stage as well as throughout the disease course. However, their relationship with the deterioration of the patient's quality of life (QoL) is still under debate. This study aimed to investigate the prevalence of NMSs and their impact on the QoL in a cohort of Moroccan patients. Methods: We carried out a cross-transactional study, where a total of 117 patients were submitted to a structured clinical interview and examination investigating motor and NMSs based on common and conventional scales...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29669261/chrebp-deficiency-leads-to-diarrhea-predominant-irritable-bowel-syndrome
#7
Ah-Reum Oh, Seonyong Sohn, Junghoon Lee, Jong-Min Park, Ki Taek Nam, Ki-Baik Hahm, Young-Bum Kim, Ho-Jae Lee, Ji-Young Cha
OBJECTIVE: Fructose malabsorption is a common digestive disorder in which absorption of fructose in the small intestine is impaired. An abnormality of the main intestinal fructose transporter proteins has been proposed as a cause for fructose malabsorption. However the underlying molecular mechanism for this remains unclear. In this study, we investigated whether carbohydrate response element-binding protein (ChREBP) plays a role in intestinal fructose absorption through the regulation of genes involved in fructose transport and metabolism and ion transport...
April 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29666844/burnout-among-anesthetists-and-intensive-care-physicians
#8
Audrius Mikalauskas, Rimantas Benetis, Edmundas Širvinskas, Judita Andrejaitienė, Šarūnas Kinduris, Andrius Macas, Žilvinas Padaiga
Burnout is a syndrome of depersonalization, emotional exhaustion, and low personal accomplishment. Little is known about burnout in physicians. Our objective was to determine the prevalence of burnout among anesthetists and intensive care physicians, and associations between burnout and personal, as well as professional, characteristics. Methods: In total, 220 anesthetists and intensive care physicians were contacted by email, asking them to participate in the study. For depression screening the PHQ-2 questionnaire, for problem drinking, CAGE items were used...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29662721/neural-mechanisms-of-qigong-sensory-training-massage-for-children-with-autism-spectrum-disorder-a-feasibility-study
#9
Kristin K Jerger, Laura Lundegard, Aaron Piepmeier, Keturah Faurot, Amanda Ruffino, Margaret A Jerger, Aysenil Belger
Objectives: Despite the enormous prevalence of autism spectrum disorder (ASD), its global impact has yet to be realized. Millions of families worldwide need effective treatments to help them get through everyday challenges like eating, sleeping, digestion, and social interaction. Qigong Sensory Training (QST) is a nonverbal, parent-delivered intervention recently shown to be effective at reducing these everyday challenges in children with ASD. This study tested the feasibility of a protocol for investigating QST's neural mechanism...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29658531/preliminary-assessment-of-vibration-impacts-generated-by-the-public-transport-systems-on-pregnant-women-based-on-subjective-reactions
#10
Magdalena Kromka-Szydek, Zygmunt Dziechciowski, Paulina Tyrpin
PURPOSE: Research efforts summarised in this study were a part of preliminary investigation to evaluate the impact of pregnant women's exposure to vibrations generated by public transport system when using. METHODS: The assessment of the problem and discomfort for pregnant women, caused by the public transportation is based on a questionnaire including questions relating to the women's subjective feelings on well-being or discomfort when exposed to vibration during the ride in passenger cars or when using means of public transport...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29658462/-research-advances-in-immune-tolerance-of-allogeneic-cell-transplantation-in-preterm-infants
#11
Can Lyu, Yi Qu, De-Zhi Mu
Preterm infants are a special group, and related severe neurological, respiratory, and digestive disorders have high disability/fatality rates. Allogeneic cell transplantation may be an effective method for the prevention and treatment of these diseases. At present, animal studies have been conducted for allogeneic cell transplantation in the treatment of hypoxic-ischemic encephalopathy, bronchopulmonary dysplasia, and necrotizing enterocolitis. The main difficulty of this technique is graft-versus-host reaction (GVHR), and successful induction of immune tolerance needs to be achieved in order to solve this problem...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29653309/bioactive-extracellular-compounds-produced-by-the-dinoflagellate-alexandrium-minutum-are-highly-detrimental-for-oysters
#12
J Castrec, P Soudant, L Payton, D Tran, P Miner, C Lambert, N Le Goïc, A Huvet, V Quillien, F Boullot, Z Amzil, H Hégaret, C Fabioux
Blooms of the dinoflagellate Alexandrium spp., known as producers of paralytic shellfish toxins (PSTs), are regularly detected on the French coastline. PSTs accumulate into harvested shellfish species, such as the Pacific oyster Crassostrea gigas, and can cause strong disorders to consumers at high doses. The impacts of Alexandrium minutum on C. gigas have often been attributed to its production of PSTs without testing separately the effects of the bioactive extracellular compounds (BECs) with allelopathic, hemolytic, cytotoxic or ichthyotoxic properties, which can also be produced by these algae...
March 29, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29651112/behavioural-medicine-and-gastrointestinal-disorders-the-promise-of-positive-psychology
#13
REVIEW
Laurie Keefer
Psychosocial risk factors linked to brain-gut dysregulation are prevalent across the spectrum of gastrointestinal disorders and are associated with poor patient outcomes. Robust and reproducible data in the areas of behavioural intervention science and the brain-gut axis have led to major advances in patient care, including the routine use of brain-gut psychotherapies to manage digestive symptoms and optimize coping. The logical next step for the emerging field of psychogastroenterology is to develop a scientific framework that enables the identification of those individual characteristics and coping styles that buffer patients against the negative psychological effects of chronic gastrointestinal disorders...
April 12, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29626671/bioactivities-of-decoctions-from-plectranthus-species-related-to-their-traditional-use-on-the-treatment-of-digestive-problems-and-alcohol-intoxication
#14
Elsa Brito, Emma Gomes, Pedro L Falé, Carlos Borges, Rita Pacheco, Vitor Teixeira, Miguel Machuqueiro, Lia Ascensão, Maria Luisa M Serralheiro
ETHNOPHARMACOLOGICAL RELEVANCE: Decoctions of Plectranthus species are traditionally ingested after large meals for treatment of food digestion and alcohol abuse. AIM OF THE STUDY: This study aims at associating the digestion-related ethno-uses of Plectranthus species decoctions to molecular mechanism that might explain them: easing digestion (AChE inhibition) and treating hangover (ADH inhibition) MATERIAL AND METHODS: Decoctions from Plectranthus species were analysed for their alcohol dehydrogenase (ADH) inhibition and acetylcholinesterase (AChE) inhibition, related with alcohol metabolism and intestinal motility, respectively...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29625006/spycatcher-n-tev-a-circularly-permuted-disordered-spycatcher-variant-for-less-trace-ligation
#15
Xue-Jian Zhang, Xia-Ling Wu, Xiao-Wei Wang, Dong Liu, Shuguang Yang, Wen-Bin Zhang
The SpyTag/SpyCatcher reaction has emerged as a powerful way for bioconjugation, but it leaves a folded complex in the product after the formation of the isopeptide bond. To vary the location of the reactive residue and reduce the size of the complex and its potential immunogenicity, we engineer two circularly permuted SpyCatcher variants, SpyCatcher-N and SpyCatcher-NTEV, the latter of which possesses a TEV-recognition site for removal of the fragment containing the catalytic site. Surprisingly, both variants are found to be disordered in solution, yet still retain the ability to form an ordered complex upon reaction with SpyTag with second order rate constants of ~10 M-1∙ s-1...
April 6, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29618709/-factors-related-to-frequent-emergency-hospital-refusal-of-ambulance-transport-calls
#16
Mika Kumagai, Naomi Kitano, Erika Komatsu, Hiroyuki Doba, Masami Ueno
Purpose Among the factors that adversely affect the time needed for ambulance transport, one factor for which intervention is possible is the time it takes to choose a medical receiving facility. This research clarified the characteristics of the time, location, and severity of medical emergencies in which the choice of hospital was difficult.Methods The research covered a 1-year period from January 1 through December 31, 2014, investigating all incidents of ambulance transport for patients in Wakayama Prefecture, except for those involving pediatric patients, amounting to a total of 41,574 incidents...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/29618478/nadph-oxidase-activation-regulates-apoptotic-neutrophil-clearance-by-murine-macrophages
#17
Juhi Bagaitkar, Jing Huang, Melody Yue Zeng, Nancy K Pech, Darlene A Monlish, Lizet J Perez-Zapata, Irina Miralda, Laura G Schuettpelz, Mary C Dinauer
The phagocyte NADPH oxidase generates superoxide, the precursor to reactive oxygen species (ROS) that have both antimicrobial and immunoregulatory functions. Inactivating mutations in NADPH oxidase alleles cause chronic granulomatous disease (CGD), characterized by enhanced susceptibility to life-threatening microbial infections and inflammatory disorders, and hypomorphic NADPH oxidase alleles are associated with autoimmunity. Impaired apoptotic cell (AC) clearance is implicated as an important contributing factor in chronic inflammation and autoimmunity, but the role of NADPH oxidase-derived ROS in this process is incompletely understood...
April 4, 2018: Blood
https://www.readbyqxmd.com/read/29605849/the-use-of-methylation-sensitive-multiplex-ligation-dependent-probe-amplification-for-quantification-of-imprinted-methylation
#18
Ana Monteagudo-Sánchez, Intza Garin, Guiomar Perez de Nanclares, David Monk
Imprinting disorders are a group of congenital diseases that can result from multiple mechanisms affecting imprinted gene dosage including cytogenetic aberration and epigenetic anomalies. Quantification of CpG methylation and correct copy-number calling is required for molecular diagnosis. Methylation-sensitive multiplex ligation-dependent probe amplification (MS-MLPA) is a multiplex method that accurately measures both parameters in a single assay. This technique relies upon the ligation of MLPA probe oligonucleotides and digestion of the genomic DNA-probe hybrid complexes with the Hha1 methylation-sensitive restriction endonuclease prior to fluorescent PCR amplification with a single primer pair...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29595887/histological-alterations-in-pacific-oysters-crassostrea-gigas-that-survived-a-summer-mortality-event-in-baja-california-mexico
#19
Jorge Cáceres-Martínez, Rebeca Vásquez-Yeomans, Philippe Danigo, Carlos Reyes-Roel
A mortality episode (>90%) of triploid and diploid Pacific oysters Crassostrea gigas cultured in Baja California Sur occurred during summer 2012, coinciding with a thermal anomaly, an algal bloom, and low oxygen values. To help explain the cause of the mortalities, histological analyses and molecular tests for specific pathogens (ostreid herpesvirus 1 [OsHV-1] and Perkinsus marinus) were performed on oysters surviving at the end of the episode. Triploid oysters showed a high percentage of males (43%) and hermaphrodites (30%); 93% of these oysters were in the gonadic reabsorption stage, and in some cases, hemocytes completely filled the lumen of the gonadic follicles...
March 2018: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/29593576/vagus-nerve-as-modulator-of-the-brain-gut-axis-in-psychiatric-and-inflammatory-disorders
#20
REVIEW
Sigrid Breit, Aleksandra Kupferberg, Gerhard Rogler, Gregor Hasler
The vagus nerve represents the main component of the parasympathetic nervous system, which oversees a vast array of crucial bodily functions, including control of mood, immune response, digestion, and heart rate. It establishes one of the connections between the brain and the gastrointestinal tract and sends information about the state of the inner organs to the brain via afferent fibers. In this review article, we discuss various functions of the vagus nerve which make it an attractive target in treating psychiatric and gastrointestinal disorders...
2018: Frontiers in Psychiatry
keyword
keyword
64794
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"