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https://www.readbyqxmd.com/read/27923204/case-report-of-the-surgical-management-of-small-bowel-and-colonic-ischaemia-associated-with-anorexia-nervosa-binge-purge-subtype
#1
Ann T Foran, Cillian Clancy, Tom F Gorey
INTRODUCTION: Anorexia Nervosa affects up to 1% of the population and can present with binge/purge episodes. A paucity of literature exists regarding small bowel and colonic ischaemia relating to this common condition. We report our own experience and management of a patient with anorexia nervosa binge/purge subtype with small bowel and colon ischaemia and review existing cases in the literature. PRESENTATION OF CASE: A 32year old female self-presented to the emergency department complaining of abdominal pain, abdominal distension and vomiting on a background history of binge/purge subtype eating disorder, following consumption of a large amount of carbohydrates...
August 25, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27921198/-metabolic-surgery-or-conservative-measures-as-therapy-of-obese-type%C3%A2-2%C3%A2-diabetics
#2
REVIEW
Udo Jahn, Thomas Schubert, Sibylle Schlepp, Heinz Jürgen Deuber
After bariatric surgery there are some favourable effects on comorbidities of obesity as glucose and lipid metabolism besides weight loss. Therefore surgical measures targeting at improvement of such metabolic disorders especially diabetes type 2 has been called "metabolic surgery". The complexity of its underlying metabolic mechanisms is not yet clear, but restriction of energy and weight loss (maintenance) seem to be the cornerstones.Risks of these procedures which are drawn of the established methods of bariatric surgery are reported to be relatively low in qualified centers...
December 5, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27911932/chemical-and-cellular-assays-combined-with-in-vitro-digestion-to-determine-the-antioxidant-activity-of-flavonoids-from-chinese-bayberry-myrica-rubra-sieb-et-zucc-leaves
#3
Yu Zhang, Shiguo Chen, Chaoyang Wei, Hui Gong, Lanqi Li, Xingqian Ye
Oxidative stress is highly associated with the development of cardiovascular diseases and cancer and has drawn great attention. Natural products suggest a potential role in prevention of these disorders. The aim of this study was to investigate the antioxidant and anti-cancer properties of Chinese bayberry leaves (Myrica rubra Sieb. et Zucc.) flavonoids (BLF) comprehensively through the combination of in vitro digestion, chemical and cellular antioxidant assays. Based on the LC/MS data, the major flavonoids of BLF were myricitrin and quercetin 3-rhamnoside...
2016: PloS One
https://www.readbyqxmd.com/read/27902336/characterization-of-the-banana-streak-virus-capsid-protein-and-mapping-of-the-immunodominant-continuous-b-cell-epitopes-to-the-surface-exposed-n-terminus
#4
Jenny Vo, Paul Campbell, Nur N Mahfuzc, Ras Ramli, Daniel Pagendam, Ross Barnard, Andrew Geering
This study identified the structural proteins of two badnavirus species, Banana streak MY virus (BSMYV) and Banana streak OL virus (BSOLV), and mapped the distribution of continuous B-cell epitopes. Two different CP isoforms of about 44 and 40 kDa (CP1 and CP2) and the virion-associated protein (VAP) were consistently associated with purified virions. For both viral species, the N-terminus of CP2 was successfully sequenced by Edman degradation but that of CP1 was chemically blocked. De novo peptide sequencing of tryptic digests suggested that CP1 and CP2 derive from the same region of the P3 polyprotein but differ in the length of either the N- or C-terminus...
October 24, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27895432/prevalence-of-depression-and-anxiety-in-patients-with-chronic-digestive-system-diseases-a-multicenter-epidemiological-study
#5
An-Zhong Zhang, Qing-Cai Wang, Kun-Ming Huang, Jia-Guo Huang, Chang-Hong Zhou, Fu-Qiang Sun, Su-Wen Wang, Feng-Ting Wu
AIM: To investigate the prevalence of depression and anxiety in patients with chronic digestive system diseases. METHODS: A total of 1736 patients with chronic digestive system diseases were included in this cross-sectional study, including 871 outpatients and 865 in-patients. A self-designed General Information for Patients of the Department of Gastroenterology of General Hospitals questionnaire was used to collect each patient's general information, which included demographic data (including age, sex, marital status, and education) and disease characteristics (including major diseases, disease duration, principal symptoms, chronic pain, sleep disorder, and limited daily activities)...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27891389/a-comparative-study-of-single-incision-versus-conventional-four-ports-laparoscopic-cholecystectomy
#6
Ranendra Hajong, Debobratta Hajong, Tanie Natung, Madhur Anand, Girish Sharma
INTRODUCTION: Cholelithiasis is one of the most common disorders of the digestive tract encountered by general surgeons worldwide. Conventional or open cholecystectomy was the mainstay of treatment for a long time for this disease. In the 1980s laparoscopic surgery revolutionized the management of biliary tract diseases. It brought about a revolutionary change in the basic concepts of surgical principles and minimal access surgery gradually started to be acknowledged as a safe means of carrying out surgeries...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888864/oesophageal-disease-gastroesophageal-reflux-disease-barrett-s-oesophagus-achalasia-and-eosinophilic-oesophagitis
#7
Xavier Calvet
The most interesting conclusions and/or advances presented at Digestive Disease Week 2016 were the following: a) gastroesophageal reflux disease: proton pump inhibitor-refractory reflux disease is frequently associated with poor treatment adherence, psychiatric comorbidities and functional gastrointestinal disorders. These possible entities should be investigated in all cases of proton pump inhibitor-refractory reflux disease; b) Barrett's oesophagus: the efficacy of screening remains unclear; however, new minimally-invasive techniques such as the cytosponge allow more effective detection, both of Barrett's oesophagus and Barrett's oesophagus-associated dysplasia or neoplasia; c) achalasia: evidence indicates that peroral endoscopic myotomy is as effective as surgery and is a safer alternative; d) eosinophilic oesophagitis: high-dose proton pump inhibitors are required to rule out proton pump inhibitor-responsive eosinophilic oesophagitis; montelukast is not clearly effective in the treatment of eosinophilic oesophagitis, although moderate efficacy cannot be ruled out...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27888862/functional-and-motor-gastrointestinal-disorders
#8
Fermín Mearin, Enrique Rey, Agustín Balboa
This article discusses the most interesting presentations at Digestive Disease Week, held in San Diego, in the field of functional and motor gastrointestinal disorders. One of the most important contributions was undoubtedly the presentation of the new Rome IV diagnostic criteria for functional gastrointestinal disorders. We therefore devote some space in this article to explaining these new criteria in the most common functional disorders. In fact, there has already been discussion of data comparing Rome IV and Rome III criteria in the diagnosis of irritable bowel syndrome, confirming that the new criteria are somewhat more restrictive...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27888860/treatment-of-inflammatory-bowel-disease-what-s-new-in-digestive-disease-week-2016
#9
María Chaparro
Inflammatory bowel disease is a chronic disorder of unknown aetiology that results from a pathologic response from both the innate and acquired immune systems, leading to chronic inflammation of the gastrointestinal tract. New drugs have been introduced into the therapeutic armamentarium of inflammatory bowel disease but are not effective in all patients; moreover, among initial responders, there have been reports of loss of response over time. In addition, these drugs sometimes have adverse effects and are often expensive...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27885460/contraceptive-considerations-for-women-with-gastrointestinal-disorders
#10
REVIEW
Aparna Sridhar, Carrie A Cwiak, Andrew M Kaunitz, Rebecca H Allen
Gastroenterologists are in a unique position to assist women with chronic gastrointestinal disorders in order to optimize their health prior to pregnancy. Women, whether with chronic conditions or not, and their infants are more likely to be healthy when pregnancies are planned. Achieving a planned pregnancy at the ideal time or preventing pregnancy altogether requires the use of appropriate contraceptives. There is a broad range of contraceptives available to women in the USA, and the majority of women with digestive diseases will be candidates for all effective methods...
November 24, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27882947/arginase-2-promotes-neurovascular-degeneration-during-ischemia-reperfusion-injury
#11
Esraa Shosha, Zhimin Xu, Harumasa Yokota, Alan Saul, Modesto Rojas, R William Caldwell, Ruth B Caldwell, S Priya Narayanan
Retinal ischemia is a major cause of visual impairment and blindness and is involved in various disorders including diabetic retinopathy, glaucoma, optic neuropathies and retinopathy of prematurity. Neurovascular degeneration is a common feature of these pathologies. Our lab has previously reported that the ureahydrolase arginase 2 (A2) is involved in ischemic retinopathies. Here, we are introducing A2 as a therapeutic target to prevent neurovascular injury after retinal ischemia/reperfusion (I/R) insult. Studies were performed with mice lacking both copies of A2 (A2(-/-)) and wild-type (WT) controls (C57BL6J)...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27882059/intestinal-microbiota-as-an-alternative-therapeutic-target-for-epilepsy
#12
REVIEW
Jiaying Wu, Yuyu Zhang, Hongyu Yang, Yuefeng Rao, Jing Miao, Xiaoyang Lu
Epilepsy is one of the most widespread serious neurological disorders, and an aetiological explanation has not been fully identified. In recent decades, a growing body of evidence has highlighted the influential role of autoimmune mechanisms in the progression of epilepsy. The hygiene hypothesis draws people's attention to the association between gut microbes and the onset of multiple immune disorders. It is also believed that, in addition to influencing digestive system function, symbiotic microbiota can bidirectionally and reversibly impact the programming of extraintestinal pathogenic immune responses during autoimmunity...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/27863865/solubility-of-indium-tin-oxide-in-simulated-lung-and-gastric-fluids-pathways-for-human-intake
#13
Jens Christian Østergård Andersen, Alastair Cropp, Diane Caroline Paradise
From being a metal with very limited natural distribution, indium (In) has recently become disseminated throughout the human society. Little is known of how In compounds behave in the natural environment, but recent medical studies link exposure to In compounds to elevated risk of respiratory disorders. Animal tests suggest that exposure may lead to more widespread damage in the body, notably the liver, kidneys and spleen. In this paper, we investigate the solubility of the most widely used In compound, indium-tin oxide (ITO) in simulated lung and gastric fluids in order to better understand the potential pathways for metals to be introduced into the bloodstream...
November 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27860472/-cellular-and-molecular-mechanisms-of-action-of-bitter-compounds-recent-knowledge-and-perspective
#14
Milan Nagy, Pavel Mučaji
This overview paper describes in its introductory part bitter-tasting herbal drugs in the context of their traditional use in the loss of appetite and digestive disorders. Then, it mentions current knowledge on signals origin in bitter taste receptors leading to different, unexpected physiological processes. Newly observed biological effects of bitter tastants are correlated with modern trends of their complex study with an aim to develop new drugs primarily acting on bitter taste receptors.Key words: T2R bitter taste receptors GPCR bitters glucose homeostasis asthma ghrelin GLP-1 solitary chemosensory cells...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27859814/black-rhinoceros-diceros-bicornis-and-domestic-horse-equus-caballus-hindgut-microflora-demonstrate-similar-fermentation-responses-to-grape-seed-extract-supplementation-in%C3%A2-vitro
#15
N F Huntley, H D Naumann, A L Kenny, M S Kerley
The domestic horse is used as a nutritional model for rhinoceros maintained under human care. The validity of this model for browsing rhinoceros has been questioned due to high prevalence of iron overload disorder (IOD) in captive black rhinoceros (Diceros bicornis), which is associated with high morbidity and mortality. Iron chelators, such as tannins, are under investigation as dietary supplements to ameliorate or prevent IOD in prone species. Polyphenolic compounds variably affect microbial fermentation, so the first objective of this experiment was to evaluate the effects of grape seed extract (GSE; a concentrated source of condensed tannins; CT) on black rhinoceros hindgut fermentation...
November 13, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27856156/metabolic-profile-alterations-in-the-postmortem-brains-of-patients-with-schizophrenia-using-capillary-electrophoresis-mass-spectrometry
#16
Takashi Fujii, Kotaro Hattori, Tomoko Miyakawa, Yoshiaki Ohashi, Hajime Sato, Hiroshi Kunugi
OBJECTIVE: We aimed to find the alterations in the profiles of low-molecular-weight metabolites in the brains of schizophrenia patients that may reflect the pathophysiology of the disorder. METHOD: Human postmortem brain tissues from the frontal cortex (15 schizophrenia patients and 15 controls) and the hippocampus (14 schizophrenia patients and 15 controls) were obtained from the Stanley Foundation Neuropathology Consortium. We analyzed ~300 metabolites, using capillary electrophoresis with time-of-flight mass spectrometry...
November 15, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27853976/tapered-tip-capillary-electrophoresis-nano-electrospray-ionization-mass-spectrometry-for-ultrasensitive-proteomics-the-mouse-cortex
#17
Sam B Choi, Marta Zamarbide, M Chiara Manzini, Peter Nemes
Ultrasensitive characterization of the proteome raises the potential to understand how differential gene expression orchestrates cell heterogeneity in the brain. Here, we report a microanalytical capillary electrophoresis nano-flow electrospray ionization (CE-nanoESI) interface for mass spectrometry to enable the measurement of limited amounts of proteins in the mouse cortex. Our design integrates a custom-built CE system to a tapered-tip metal emitter in a co-axial sheath-flow configuration. This interface can be constructed in <15 min using readily available components, facilitating broad adaptation...
November 16, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27852256/health-conditions-of-inmates-in-italy
#18
Fabio Voller, Caterina Silvestri, Gianrocco Martino, Eleonora Fanti, Giorgio Bazzerla, Fabio Ferrari, Marco Grignani, Sandro Libianchi, Antonio Maria Pagano, Franco Scarpa, Cristina Stasi, Teresa Di Fiandra
BACKGROUND: Several studies have shown that prison is characterized by a higher prevalence of chronic diseases than unconfined settings. The aim of this study was to describe the characteristics and health of inmates, focusing on internal diseases. METHODS: We designed a specific clinical record using the Python programming language. We considered all of the diagnoses according to the ICD-9-CM. RESULTS: Of a total of 17,086 inmates, 15,751 were enrolled in our study (M = 14,835; F = 869), corresponding to 92...
November 16, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27849439/liver-proteome-in-diabetes-type-1-rat-model-insulin-dependent-and-independent-changes
#19
Camila Pereira Braga, Cory H T Boone, Ryan A Grove, Dana Adamcova, Ana Angélica Henrique Fernandes, Jiri Adamec, Pedro de Magalhães Padilha
Diabetes mellitus type 1 (DM1) is a major public health problem that continues to burden the healthcare systems worldwide, costing exponentially more as the epidemic grows. Innovative strategies and omics system diagnostics for earlier diagnosis or prognostication of DM1 are essential to prevent secondary complications and alleviate the associated economic burden. In a preclinical study design that involved streptozotocin (STZ)-induced DM1, insulin-treated STZ-induced DM1, and control rats, we characterized the insulin-dependent and -independent changes in protein profiles in liver samples...
November 16, 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27843730/abdominal-pain-and-ascites-not-always-related-to-portal-hypertension
#20
Fredy Nehme, Gilbert Kisang, Michael Green, Nathan Tofteland
Eosinophilic gastroenteritis is a rare inflammatory disorder of the gastrointestinal tract with an estimated prevalence of one in 100,000. The typical presentation consists of vague gastrointestinal symptoms with the mucosal involvement of the digestive system. Rarely, it presents as eosinophilic ascites. We report the case of a 22-year-old female who presented with acute onset abdominal pain and ascites. The laboratory studies were remarkable for eosinophilia and the ascitic fluid demonstrated high eosinophilic counts...
October 3, 2016: Curēus
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