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https://www.readbyqxmd.com/read/28437888/protective-effects-of-tranilast-on-experimental-colitis-in-rats
#1
Yoshiki Seto, Kouki Kato, Ryota Tsukada, Hiroki Suzuki, Yuuki Kaneko, Yoshiki Kojo, Hideyuki Sato, Satomi Onoue
The present study aimed to verify the efficacy of tranilast (TL) for treating inflammatory bowel disease (IBD) with the use of an experimental colitis model. The experimental colitis model was prepared by intrarectal instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 40mg/kg) dissolved in water containing 25% ethanol. The pharmacological effects of TL after repeated oral administration were evaluated by biomarker and histological analyses, and the pharmacokinetic behavior of TL was also examined after single oral administration...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437775/effect-of-nitrification-inhibitors-on-mitigating-n2o-and-no-emissions-from-an-agricultural-field-under-drip-fertigation-in-the-north-china-plain
#2
Di Tian, Yuanyuan Zhang, Yizhen Zhou, Yujing Mu, Junfeng Liu, Chenglong Zhang, Pengfei Liu
N2O and NO emissions from a winter wheat-summer maize rotation field with five different treatments in the North China Plain (NCP) were comparably investigated from 8 October 2014 to 11 October 2015. Compared with the treatments with only flood or drip irrigation, evident emission peaks of N2O and NO from the fertilization treatments with flood irrigation (A-Flood) and with drip fertigation (A-Drip) were observed after each fertilization event, whereas their emissions from the fertilization treatments with nitrification inhibitors under drip fertigation (A+DCD-Drip and A+Nitrapyrin-Drip) were greatly suppressed...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437772/shifts-in-soil-microbial-metabolic-activities-and-community-structures-along-a-salinity-gradient-of-irrigation-water-in-a-typical-arid-region-of-china
#3
Lijuan Chen, Changsheng Li, Qi Feng, Yongping Wei, Hang Zheng, Yan Zhao, Yongjiu Feng, Huiya Li
Saline water irrigation can change soil environment, which thereby influence soil microbial process. Based on a field experiment, the shifts in soil microbial metabolic activities and community structures under five irrigation salinities were studied using Biolog and metagenomic methods in this study. The results demonstrated that microbial metabolic activities were greatly restrained in saline water irrigated soils, as average well color development (AWCD) reduced under all saline water irrigation treatments...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437707/effect-of-pco2-on-direct-flue-gas-mineral-carbonation-at-pilot-scale
#4
Ikbel Mouedhen, Nassima Kemache, Louis-César Pasquier, Emmanuelle Cecchi, Jean-François Blais, Guy Mercier
Concerns about global warming phenomena induced the development of research about the control of anthropogenic greenhouse gases emissions. The current work studies on the scaling up of aqueous mineral carbonation route to reduce the CO2 emissions at the chimney of industrial emitters. The reactivity of serpentinite in a stirred tank reactor was studied for several partial pressures of CO2 (pCO2) (0.4, 0.7, 1.3 and 1.6 bar). Prior to carbonation, the feedstock was finely grinded and dehydroxyled at 650 °C by a thermal treatment...
April 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28437697/catalytic-polymer-clay-composite-for-enhanced-removal-and-degradation-of-diazinon
#5
Itamar A Shabtai, Yael G Mishael
It is well established that organophosphate pesticides, such as diazinon, pose environmental and health risks. Diazinon is prone to rapid acidic hydrolysis, forming the less toxic compound 2-isopropyl-6-methyl-4-pyrimidinol (IMP). In this study, diazinon surface catalyzed hydrolysis was achieved by its adsorption to a composite, based on protonated poly (4-vinyl-pyridine-co-styrene) (HPVPcoS) and montmorillonite (MMT) clay. The adsorption affinity and kinetics of diazinon to HPVPcoS-MMT were significantly higher than those obtained to the deprotonated PVPcoS-MMT, emphasizing the importance of hydrogen bonding...
April 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28437649/occurrences-and-removal-of-pharmaceuticals-and-personal-care-products-ppcps-in-drinking-water-and-water-sewage-treatment-plants-a-review
#6
REVIEW
Yi Yang, Yong Sik Ok, Ki-Hyun Kim, Eilhann E Kwon, Yiu Fai Tsang
In recent years, many of micropollutants have been widely detected because of continuous input of pharmaceuticals and personal care products (PPCPs) into the environment and newly developed state-of-the-art analytical methods. PPCP residues are frequently detected in drinking water sources, sewage treatment plants (STPs), and water treatment plants (WTPs) due to their universal consumption, low human metabolic capability, and improper disposal. When partially metabolized PPCPs are transferred into STPs, they elicit negative effects on biological treatment processes; therefore, conventional STPs are insufficient when it comes to PPCP removal...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437458/isomalto-oligosaccharides-ameliorate-visceral-hyperalgesia-with-repair-damage-of-ileal-epithelial-ultrastructure-in-rats
#7
Weida Wang, Haiwei Xin, Xiucai Fang, Hongtao Dou, Fangyi Liu, Dan Huang, Shaomei Han, Guijun Fei, Liming Zhu, Shenghua Zha, Hong Zhang, Meiyun Ke
BACKGROUND: Treatment of irritable bowel syndrome (IBS) with probiotics has achieved effectiveness to a certain extent. Whether prebiotics will work is still unclear. This study aimed to investigate the therapeutic effects of the prebiotic isomalto-oligosaccharides (IMO) on visceral hypersensitivity (VHS) in rats and to explore potential mechanism. METHODS: Water avoidance stress (WAS) was used to induce VHS in rats. The score for the abdominal withdrawal reflex (AWR) was determined while colorectal distension and compared between VHS group and control group in order to validate VHS preparation...
2017: PloS One
https://www.readbyqxmd.com/read/28436921/feasibility-study-of-entrance-and-exit-dose-measurements-at-the-contra-lateral-breast-with-alanine-electron-spin-resonance-dosimetry-in-volumetric-modulated-radiotherapy-of-breast-cancer
#8
Daniela M Wagner, Petra Huettenrauch, Mathias Anton, Philip von Voigts-Rhetz, Klemens Zink, Hendrik Wolff
PURPOSE: The Physikalisch-Technische Bundesanstalt (PTB) has established a secondary standard measurement system for the dose to water, DW, based on alanine/ ESR (Anton et. al. 2013). The aim of this study was to test the established measurements system for out of field measurements inpatient with breast cancer. METHOD AND MATERIALS: A set of five alanine pellets were affixed to each patients` skin at the contra lateral breast beginning at the sternum and extending over the mammilla to the distal surface...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28436827/reductive-precipitation-of-sulfate-and-soluble-fe-iii-by-desulfovibrio-vulgaris-electron-donor-regulates-intracellular-electron-flow-and-nano-fes-crystallization
#9
Chen Zhou, Yun Zhou, Bruce E Rittmann
Fully understanding the metabolism of SRB provides fundamental guidelines for allowing the microorganisms to provide more beneficial services in water treatment and resource recovery. The electron-transfer pathway of sulfate respiration by Desulfovibrio vulgaris is well studied, but still partly unresolved. Here we provide deeper insight by comprehensively monitoring metabolite changes during D. vulgaris metabolism with two electron donors, lactate and pyruvate, in presence or absence of citrate-chelated soluble Fe(III) as an additional competing electron acceptor...
April 19, 2017: Water Research
https://www.readbyqxmd.com/read/28436692/rhizospheric-soil-enzyme-activities-and-phytominimg-potential-of-aeluropus-lagopoides-and-cyperus-conglomeratus-growing-in-contaminated-soils-at-the-banks-of-artificial-lake-of-reclaimed-wastewater
#10
Zahid Khorshid Abbas
This work investigates the phytoremediation potential of Aeluropus lagopoides and Cyperus conglomeratus, growing indigenously in the vicinity of artificial lake of reclaimed water in Tabuk, Saudi Arabia. The sampling sites were located at different distance from the waste water treatment plants. Trace metal contents were higher in roots than shoots in both these plants. Soil urease activity in rhizophere increased linearly along the sampling sites, however, soil alkaline phosphatase and β-glucosidase activities was greater at site 2 but were declined at site 3...
April 24, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28436604/solvent-free-mechanochemical-synthesis-of-nitrogen-doped-nanoporous-carbon-for-electrochemical-energy-storage
#11
Christina Schneidermann, Nicolas Jaeckel, Steffen Oswald, Lars Giebeler, Volker Presser, Lars Borchardt
Nitrogen-doped nanoporous carbons have been synthesized by a solvent-free mechanochemically-induced one-pot synthesis. This facile approach involves the mechanochemical treatment and carbonization of three solid materials: potassium carbonate, urea, and lignin, which is a waste product from pulp industry. The resulting nitrogen-doped porous carbons offer a very high specific surface area up to 3000 m2 g-1 and large pore volume up to 2 cm3 g-1. The mechanochemical reaction and the impact of activation and functionalization are investigated by nitrogen- and water physisorption and high-resolution X-ray photoelectron spectroscopy (XPS)...
April 24, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28436522/integrated-hydrogen-evolution-and-water-cleaning-via-a-robust-graphene-supported-noble-metal-free-fe1-xcoxs2-system
#12
Yingying Fan, Dandan Wang, Dongxue Han, Yingming Ma, Shuang Ni, Zhonghui Sun, Xiandui Dong, Li Niu
In an electrocatalytic hydrogen evolution reaction (HER) system, a cathodic H(+) resource, an anodic sacrificial agent and a robust catalyst are three essential factors. Industry wastewater emissions, containing high levels of acidity and organic dyes, actually can satisfy the material requirements for the HER. Herein, a new HER method is proposed, taking acidic ions from wastewater as a cathodic resource to produce H2, while organic dye waste acts as an anodic sacrifice to balance the reaction. In such a way, a sustainable H2 energy source can be generated and clean water is obtained as well...
April 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28436319/in-vitro-antioxidant-and-in-vivo-hypolipidemic-effects-of-the-king-oyster-culinary-medicinal-mushroom-pleurotus-eryngii-var-ferulae-ddl01-agaricomycetes-in-rats-with-high-fat-diet-induced-fatty-liver-and-hyperlipidemia
#13
Jun-Hui Choi, Dae-Won Kim, Seung Kim, Sung-Jun Kim
We investigated the effect of the culinary-medicinal mushroom Pleurotus eryngii var. ferulae DDL01 on oxidative damage in the liver and brain and a high-fat/high-cholesterol-induced hyperlipidemic model. In in vitro studies, the water extracts of the fruiting bodies showed strong scavenging activities of DPPH (139.46 ± 3.2 μg) and hydroxyl (139.46 ± 3.2 μg) radicals. Moreover, the extracts showed Fe2+ chelating and reducing abilities, as well as a large amount of polyphenols and an inhibitory effect on lipid peroxidation in the liver and brain tissues...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28435973/acclimatization-to-middle-altitude-hypoxia-protects-against-developmental-and-cognitive-deficits-caused-by-acute-fetal-hypoxia-in-mice
#14
Hui-Lang Liu, Yong-Mei Sun, Chuan-Yu Li, Hai-Chen Niu, Min Su, Jing-Kun Wang
Acute fetal hypoxia (AFH) can elicit postnatal motor deficits and cognitive impairments. To test whether lifelong acclimatization to middle altitude (MA) hypoxia has protective effects on the impairments caused by AFH, ICR mice bred at 1 900 m altitude for 6-7 generations were evaluated under AFH. On gestation day 9 (GD 9), 13 (GD 13) or 17 (GD 17), pregnant mice received a single exposure to acute hypoxia (7% O2, 6 h). Physiological and neurodevelopmental behaviors, motor function (open field), spatial learning and memory (Morris water maze), and anxiety level (elevated plus maze) were examined in the offspring from neonate to adulthood...
April 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28435972/-glp-1-gip-gcg-receptor-triagonist-improves-the-cognitive-behaviors-in-triple-transgenic-mice-of-alzheimer-s-disease
#15
Juan-Juan Jiao, Christian Hölscher, Tian Li, Xue-Fan Dong, Xue-Song Qu, Yue Cao, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Qi
Alzheimer's disease (AD) is a progressively neurodegenerative disorder, which seriously affects human health but is still irreversible up to now. Recent studies indicate that type 2 diabetes mellitus (T2DM) is an important risk factor for AD, and the drugs used for treatment of T2DM have shown some neuroprotective effects in the treatment of AD. Glucagon-like peptide-1 (GLP-1)/ glucose-dependent insulinotropic polypeptide (GIP)/glucagon (Gcg) receptor Triagonist is a new monomeric polypeptide equally activating the GLP-1/GIP/Gcg receptors, which is built on the basis of GLP-1/Gcg receptor coagonist core sequence, and incorporated with partial amino acids of GIP...
April 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28435877/design-and-function-of-biomimetic-multilayer-water-purification-membranes
#16
Shengjie Ling, Zhao Qin, Wenwen Huang, Sufeng Cao, David L Kaplan, Markus J Buehler
Multilayer architectures in water purification membranes enable increased water throughput, high filter efficiency, and high molecular loading capacity. However, the preparation of membranes with well-organized multilayer structures, starting from the nanoscale to maximize filtration efficiency, remains a challenge. We report a complete strategy to fully realize a novel biomaterial-based multilayer nanoporous membrane via the integration of computational simulation and experimental fabrication. Our comparative computational simulations, based on coarse-grained models of protein nanofibrils and mineral plates, reveal that the multilayer structure can only form with weak interactions between nanofibrils and mineral plates...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28435247/delivery-of-curcumin-by-directed-self-assembled-micelles-enhances-therapeutic-treatment-of-non-small-cell-lung-cancer
#17
Wen-Ting Zhu, Sheng-Yao Liu, Lei Wu, Hua-Li Xu, Jun Wang, Guo-Xin Ni, Qing-Bing Zeng
BACKGROUND: It has been widely reported that curcumin (CUR) exhibits anticancer activity and triggers the apoptosis of human A549 non-small-cell lung cancer (NSCLC) cells. However, its application is limited owing to its poor solubility and bioavailability. Therefore, there is an urgent need to develop a new CUR formulation with higher water solubility and better biocompatibility for clinical application in the future. MATERIALS AND METHODS: In this study, CUR-loaded methoxy polyethylene glycol-polylactide (CUR/mPEG-PLA) polymeric micelles were prepared by a thin-film hydration method...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28435078/preformulation-studies-of-ceftriaxone-for-pediatric-non-parenteral-administration-as-an-alternative-to-existing-injectable-formulations
#18
Tina Kauss, Mathieu Marchivie, Thida Phoeung, Alexandra Gaubert, Amélie Désiré, Giovanni Tonelli, Chantal Boyer, Marie-Hélène Langlois, Anthony Cartwright, Melba Gomes, Nicholas White, Karen Gaudin
Ceftriaxone, a third generation cephalosporin, has a wide antibacterial spectrum that has good CNS penetration, which makes it potentially suitable for initial treatment of severe neonatal pediatric infections providing suitable formulation. We evaluated its physicochemical and technical characteristics to assess its potential for development as a non-parenteral dosage form. As ceftriaxone is marked only for injectable use, these data are not available. Using HPLC and Karl Fischer titration, sensitivity of ceftriaxone to water, feasibility and impact of pharmaceutical processes and compatibility with common pharmaceutical excipients were assessed...
April 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28434758/mallards-anas-platyrhynchos-and-wastewater-ponds-part-ii-developmental-physiological-morphological-and-behavioural-effects-of-ingestion-of-secondary-clarified-effluent-water
#19
K B Tierney, P O Welsh, M Mills, S Nason, D R Barreda, C A Paszkowski
Rather than migrating, mallard ducks may choose to overwinter in northern cities on open-water thermal refuges, such as municipal wastewater treatment ponds, which in Edmonton, Canada, stay ≥10°C during frigid winter months. Refuging mallards spend appreciable time daily on these ponds and hydrate using secondary clarified municipal wastewater (SCEW). We aimed to determine if SCEW ingestion affected mallard health. To this end, we gavaged newly hatched mallards (domesticated Pekin strain) over their first month with SCEW, as well as water representing negative and positive controls (municipal tap water, and the primary active ingredient from birth control pills, 17α-ethinyl estradiol (EE2), respectively)...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28434746/supplementing-an-immunomodulatory-feed-ingredient-to-modulate-thermoregulation-physiologic-and-production-responses-in-lactating-dairy-cows-under-heat-stress-conditions
#20
T Leiva, R F Cooke, A P Brandão, K M Schubach, L F D Batista, M F Miranda, E A Colombo, R O Rodrigues, J R G Junior, R L A Cerri, J L M Vasconcelos
This study compared vaginal temperature, physiologic, and productive parameters in lactating dairy cows supplemented or not with Omnigen-AF (Phibro Animal Health, Teaneck, NJ) during the summer months in a tropical environment. Thirty-two lactating, primiparous (n = 16) and multiparous (n = 16) pregnant Holstein × Gir cows were ranked by parity, days in milk, body weight, and body condition score (BCS), and assigned to receive (SUPP; n = 16) or not (CON; n = 16) Omnigen-AF (Phibro Animal Health, Teaneck, NJ) at 56 g/cow daily (as-fed basis)...
April 20, 2017: Journal of Dairy Science
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