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Prostate cancer radiotherapy

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https://www.readbyqxmd.com/read/29333958/focal-mri-guided-salvage-high-dose-rate-brachytherapy-in-patients-with-radiorecurrent-prostate-cancer
#1
Metha Maenhout, Max Peters, Marco van Vulpen, Marinus A Moerland, Richard P Meijer, Maurice A A J van den Bosch, Paul L Nguyen, Steven J Frank, Jochem R N van der Voort van Zyp
INTRODUCTION: Whole-gland salvage treatment of radiorecurrent prostate cancer has a high rate of severe toxicity. The standard of care in case of a biochemical recurrence is androgen deprivation treatment, which is associated with morbidity and negative effects on quality of life. A salvage treatment with acceptable toxicity might postpone the start of androgen deprivation treatment, might have a positive influence on the patients' quality of life, and might even be curative. Here, toxicity and biochemical outcome are described after magnetic resonance imaging-guided focal salvage high-dose-rate brachytherapy in patients with radiorecurrent prostate cancer...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331524/strategies-and-technical-challenges-for-imaging-oligometastatic-disease-recommendations-from-the-european-organisation-for-research-and-treatment-of-cancer-imaging-group
#2
REVIEW
Nandita M deSouza, Yan Liu, Arturo Chiti, Daniela Oprea-Lager, Géraldine Gebhart, Bernard E Van Beers, Ken Herrmann, Frederic E Lecouvet
Patients with oligometastatic disease (OMD) often have controllable symptoms, and cures are possible. Technical improvements in surgery and radiotherapy have introduced the option of metastasis-directed ablative therapies as an adjunct or alternative to standard-of-care systemic therapies. Several clinical trials and registries are investigating the benefit of these therapeutic approaches across several cancer sites. This requires that patients are correctly included and followed with appropriate imaging. This article discusses the evidence and offers recommendations for the implementation of standard-of-care (Response Evaluation Criteria in Solid Tumours measurements on computed tomography [CT], magnetic resonance imaging [MRI] and bone scintigraphy) and advanced imaging modalities (functional, metabolic and radionuclide targeted) for identifying and following up patients with OMD...
January 10, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29330583/utilization-of-active-surveillance-and-watchful-waiting-for-localized-prostate-cancer-in-the-daily-practice
#3
Jan Herden, Lothar Weissbach
PURPOSE: To analyze the utilization of Active Surveillance (AS) and Watchful Waiting (WW) in the daily routine setting, since both are non-invasive treatment options for localized prostate cancer (PCa), which are used in a curative (AS) or palliative (WW) setting. Since differentiation of both strategies is not always clear, patients were compared with respect to the inclusion criteria, frequency of follow-up examinations (Prostate Specific Antigen = PSA tests, rebiopsies), and initiation of a deferred treatment...
January 12, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29325451/expression-of-sestrin-genes-in-radiotherapy-for-prostate-cancer-and-its-association-with-fatigue-a-proof-of-concept-study
#4
Velda J Gonzalez, Farnoosh Abbas-Aghababazadeh, Brooke L Fridley, Tomar Ghansah, Leorey N Saligan
Genetic factors that influence inflammation and energy production/expenditure in cells may affect patient outcomes following treatment with external beam radiation therapy (EBRT). Sestrins, stress-inducible genes with antioxidant properties, have recently been implicated in several behaviors including fatigue. This proof-of-concept study explored whether the sestrin family of genes ( SESN1, SESN2, and SESN3) were differentially expressed from baseline to the midpoint of EBRT in a sample of 26 Puerto Rican men with nonmetastatic prostate cancer...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29323427/duration-of-androgen-deprivation-therapy-and-nadir-of-testosterone-at-20-ng-dl-predict-testosterone-recovery-to-supracastrate-level-in-prostate-cancer-patients-who-received-external-beam-radiotherapy
#5
Akinori Takei, Shinichi Sakamoto, Ken Wakai, Takaaki Tamura, Yusuke Imamura, Minhui Xu, Maihulan Maimaiti, Koji Kawamura, Takashi Imamoto, Akira Komiya, Koichiro Akakura, Tomohiko Ichikawa
OBJECTIVES: To determine the predictors of testosterone recovery after termination of androgen deprivation therapy in high/intermediate-risk prostate cancer patients receiving external beam radiation therapy with neoadjuvant and adjuvant androgen deprivation therapy. METHODS: A total of 82 patients who underwent external beam radiation therapy with androgen deprivation therapy for prostate cancer were retrospectively analyzed. Serum testosterone levels after androgen deprivation therapy terminations were studied...
January 11, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29322625/variations-in-dosimetric-distribution-and-plan-complexity-with-collimator-angles-in-hypofractionated-volumetric-arc-radiotherapy-for-treating-prostate-cancer
#6
Ming-Hsien Li, Sheng-Fang Huang, Chih-Chieh Chang, Jang-Chun Lin, Jo-Ting Tsai
PURPOSE: Hypofractionated radiotherapy can reduce treatment durations and produce effects identical to those of conventionally fractionated radiotherapy for treating prostate cancer. Volumetric arc radiotherapy (VMAT) can decrease the treatment machine monitor units (MUs). Previous studies have shown that VMAT with multileaf collimator (MLC) rotation exhibits better target dose distribution. Thus, VMAT with MLC rotation warrants further investigation. METHODS AND MATERIALS: Ten patients with prostate cancer were included in this study...
January 11, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29320576/targeting-dna-repair-with-pnkp-inhibition-sensitizes-radioresistant-prostate-cancer-cells-to-high-let-radiation
#7
Pallavi Srivastava, Asitikantha Sarma, Chandra Mohini Chaturvedi
High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used as a method for advanced radiotherapy in the treatment of cancer. It has many advantages over the conventional photon based radiotherapy using Co-60 gamma or high energy X-rays from a Linear Accelerator. However, charged particle therapy is very costly. One way to reduce the cost as well as irradiation effects on normal cells is to reduce the dose of radiation by enhancing the radiation sensitivity through the use of a radiomodulator...
2018: PloS One
https://www.readbyqxmd.com/read/29320570/image-guided-whole-pelvic-intensity-modulated-radiotherapy-for-biochemical-recurrence-following-radical-prostatectomy-in-high-risk-prostate-cancer-patients
#8
Sang Jun Byun, Young Seok Kim, Hanjong Ahn, Choung-Soo Kim
BACKGROUND: The optimal field size of salvage radiotherapy (SRT) for biochemical recurrence, particularly for patients with high-risk prostate cancer, remains undefined. This retrospective analysis was performed to investigate oncological outcomes as well as treatment-related toxicity following salvage intensity-modulated radiotherapy (IMRT) to the whole pelvis and to compare the results with other studies implementing a small field size of the prostate bed. METHODS: The medical records of 170 patients with high-risk prostate cancer who received SRT for biochemical recurrence following prostatectomy were reviewed...
2018: PloS One
https://www.readbyqxmd.com/read/29317377/multiparametric-mri-for-the-detection-of-local-recurrence-of-prostate-cancer-in-the-setting-of-biochemical-recurrence-after-low-dose-rate-brachytherapy
#9
Luca F Valle, Matthew D Greer, Joanna H Shih, Tristan Barrett, Yan Mee Law, Andrew B Rosenkrantz, Haytham Shebel, Akhil Muthigi, Daniel Su, Maria J Merino, Bradford J Wood, Peter A Pinto, Andra V Krauze, Aradhana Kaushal, Peter L Choyke, Barış Türkbey, Deborah E Citrin
PURPOSE: Prostate multiparametric magnetic resonance imaging (mpMRI) has utility in detecting post-radiotherapy local recurrence. We conducted a multireader study to evaluate the diagnostic performance of mpMRI for local recurrence after low dose rate (LDR) brachytherapy. METHODS: A total of 19 patients with biochemical recurrence after LDR brachytherapy underwent 3T endorectal coil mpMRI with T2-weighted imaging, dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI) with pathologic confirmation...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29315174/oligorecurrent-nodal-prostate-cancer-long-term-results-of-an-elective-nodal-irradiation-approach
#10
Sebastien Tran, Sandra Jorcano, Teresa Falco, Giorgio Lamanna, Raymond Miralbell, Thomas Zilli
OBJECTIVES: The objective of this study was to report long-term results of elective nodal radiotherapy (ENRT) in prostate cancer (PCa) patients with oligorecurrent nodal disease after primary treatment. METHODS: Data of 53 oligorecurrent PCa patients (N1 and/or M1a) with ≤5 nodal metastases (n=108) treated with ENRT combined with androgen deprivation therapy (ADT) between 2004 and 2016 were retrospectively reviewed. Median prostate-specific antigen (PSA) and PSA doubling time (DT) were 3...
January 8, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29313165/effectiveness-of-sacral-nerve-stimulation-in-fecal-incontinence-after-multimodal-oncologic-treatment-for-pelvic-malignancies-a-multicenter-study-with-2-year-follow-up
#11
M Schiano di Visconte, G A Santoro, N Cracco, G Sarzo, G Bellio, M Brunner, Z Cui, K E Matzel
BACKGROUND: To assess whether sacral nerve stimulation (SNS) is an effective treatment for severe fecal incontinence (FI) after radiotherapy (RT)/chemoRT (CRT) in combination with pelvic surgery. METHODS: A multicenter study was conducted on patients with FI that developed after multimodal therapy for pelvic tumors and was refractory to non-operative management, who were treated with SNS between November 2009 and November 2012. Data were prospectively collected and retrospectively analyzed...
January 8, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29306674/a-comparison-of-early-prostate-specific-antigen-decline-between-prostate-brachytherapy-and-different-fractionation-of-external-beam-radiation-impact-on-biochemical-failure
#12
Daniel Taussky, Stéphane Bedwani, Nissan Meissner, Jean-Paul Bahary, Carole Lambert, Maroie Barkati, Marie-Claude Beauchemin, Cynthia Ménard, Guila Delouya
PURPOSE: The aim of this study was to compare early prostate-specific antigen (PSA) decline patterns and PSA nadirs between low-dose-rate seed prostate brachytherapy (LDR-PB) and different fractionations of external beam radiotherapy (EBRT) and their predictive importance for biochemical failure (bF). METHODS AND MATERIALS: Patients with D'Amico low- or intermediate-risk prostate cancer who underwent a single-modality treatment without androgen deprivation were included in this study...
January 3, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29306514/intermediate-endpoints-after-postprostatectomy-radiotherapy-5-year-distant-metastasis-to-predict-overall-survival
#13
William C Jackson, Krithika Suresh, Vasu Tumati, Steven G Allen, Robert T Dess, Simpa S Salami, Arvin George, Samuel D Kaffenberger, David C Miller, Jason W D Hearn, Shruti Jolly, Rohit Mehra, Brent K Hollenbeck, Ganesh S Palapattu, Matthew Schipper, Felix Y Feng, Todd M Morgan, Neil B Desai, Daniel E Spratt
BACKGROUND: Intermediate clinical endpoints (ICEs) prognostic for overall survival (OS) are needed for men receiving postprostatectomy radiation therapy (PORT) to improve clinical trial design. OBJECTIVE: To identify a potential ICE for men receiving PORT. DESIGN, SETTING, AND PARTICIPANTS: We performed an institutional review board-approved multi-institutional retrospective study of 566 men consecutively treated with PORT at tertiary care centers from 1986 to 2013...
January 3, 2018: European Urology
https://www.readbyqxmd.com/read/29305198/association-between-primary-local-treatment-and-non-prostate-cancer-mortality-in-men-with-non-metastatic-prostate-cancer
#14
Christopher J D Wallis, Raj Satkunasivam, Sender Herschorn, Calvin Law, Arun Seth, Ronald T Kodama, Girish S Kulkarni, Robert K Nam
OBJECTIVE: To assess the association between local treatment modality, surgery or radiotherapy, and non-prostate cancer and cardiovascular mortality in patients treated for non-metastatic prostate cancer, given the high competing risk of mortality in this population. METHODS: We performed a population-based, retrospective cohort study of men treated for non-metastatic prostate cancer in Ontario, Canada from 2002-2009. Patients treated with surgery and radiotherapy were matched on demographics, comorbidity, and cardiovascular risk factors...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29304808/prospective-longitudinal-outcomes-of-quality-of-life-after-laparoscopic-radical-prostatectomy-compared-with-retropubic-radical-prostatectomy
#15
Katsuyoshi Hashine, Toshio Kakuda, Shunsuke Iuchi, Tadanori Hosokawa, Iku Ninomiya
BACKGROUND: There have been few reports on health-related quality of life (HRQOL) after laparoscopic radical prostatectomy (LRP) in Japanese patients. The aim of this study is to assess changes in HRQOL during 36 months after LRP compared with retropubic radical prostatectomy (RRP). METHODS: The subjects were 105 consecutive patients treated with LRP between 2011 and 2012. HRQOL was evaluated using the International Prostate Symptom Score (IPSS), Medical Outcome Study 8-Items Short Form Health Survey (SF-8), and Expanded Prostate Cancer Index Composite (EPIC) at baseline and 1, 3, 6, 12 and 36 months after surgery...
January 5, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29301928/the-utility-of-pet-ct-in-external-radiation-therapy-planning-of-prostate-cancer
#16
Jeremie Calais, Minsong Cao, Nicholas G Nickols
Radiotherapy and radical prostatectomy are the definitive treatment options for patients with localized prostate cancer. A rising PSA after radical prostatectomy indicates prostate cancer recurrence, and these patients may still be cured with salvage radiotherapy. To maximize chance for cure, irradiated volumes should completely encompass the extent of disease. Therefore, accurate estimation of the location of disease is critical for radiotherapy planning in both the definitive and salvage settings. Conventional imaging for prostate cancer has limited sensitivity for detection of disease both at initial staging and at biochemical recurrence...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29300184/correlations-between-contouring-similarity-metrics-and-simulated-treatment-outcome-for-prostate-radiotherapy
#17
Dale Roach, Michael G Jameson, Jason A Dowling, Martin Andrew Ebert, Peter B Greer, Angel M Kennedy, Sandie Watt, Lois C Holloway
Many similarity metrics exist for inter-observer contouring variation studies, however no correlation between metric choice and prostate cancer radiotherapy dosimetry has been explored. These correlations were investigated in this study. Two separate trials were undertaken, the first a thirty-five patient cohort with three observers, the second a five patient dataset with ten observers. Clinical and planning target volumes (CTV and PTV), rectum, and bladder were independently contoured by all observers in each trial...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29299174/lymph-node-ratio-determines-the-benefit-of-adjuvant-radiotherapy-in-pathologically-3-or-less-lymph-node-positive-prostate-cancer-after-radical-prostatectomy-a-population-based-analysis-with-propensity-score-matching
#18
Yi-Jun Kim, Changhoon Song, Keun-Yong Eom, In Ah Kim, Jae-Sung Kim
Background: The survival benefit of adjuvant radiotherapy (ART) in prostate adenocarcinoma, with limited numbers of pathologically involved lymph nodes (LNs) after radical prostatectomy (RP), is controversial. Materials and Methods: From 2004 to 2014, data for prostate cancer patients categorized as N1M0 after RP were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. After propensity-score matching, the 10-year cancer-specific survival (CSS) rates between patients who received ART (ART group) or did not/unknown (no-ART group) were compared for each stratum of lymph node ratio (LNR) (%) according to the number of involved LNs...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297887/prostate-cancer-utility-of-adt-during-early-salvage-radiotherapy
#19
Clemens Thoma
No abstract text is available yet for this article.
January 3, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29296018/prostate-cancer-radiation-and-urethral-strictures-a-systematic-review-and-meta-analysis
#20
Mohannad A Awad, Thomas W Gaither, E Charles Osterberg, Gregory P Murphy, Nima Baradaran, Benjamin N Breyer
BACKGROUND: We performed a systematic review and meta-analysis to determine the prevalence and predictors of urethral stricture development post radiation therapy (RT) for prostate cancer (PCa). METHODS: Published articles in PubMed/Medline, Cochrane, and Embase databases from January 2000 to April 2016 were queried. Inclusion criteria were any study that reported the prevalence of urethral strictures following external beam radiation therapy (EBRT), brachytherapy (BT), or both as a primary treatment for PCa...
January 2, 2018: Prostate Cancer and Prostatic Diseases
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