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https://www.readbyqxmd.com/read/28635325/effect-of-salt-loading-on-baroreflex-sensitivity-in-reduced-renal-mass-hypertension
#1
Besim Özaykan, Eylem Taskin, Ali Magemizoğlu
BACKGROUND: High dietary salt, as well as renal mass reduction, is known to decrease baroreflex sensitivity in rats. However, the effect of high salt intake on baroreflex sensitivity is unknown in reduced renal mass (RRM) hypertension; therefore, the aim of this study was to investigate the effects of salt loading on arterial baroreflex sensitivity and mean arterial pressure (MAP) in RRM hypertension. METHODS: Both RRM and sham-operated control (SO) rats were loaded with 0...
June 21, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28633967/the-effects-of-chronic-faah-inhibition-on-myocardial-lipid-metabolism-in-normotensive-and-doca-salt-hypertensive-rats
#2
Agnieszka Polak, Ewa Harasim-Symbor, Barbara Malinowska, Irena Kasacka, Anna Pędzińska-Betiuk, Jolanta Weresa, Adrian Chabowski
AIMS: There is significant evidence that the endocannabinoid system (ECS) takes part in the regulation of the cardiovascular system in hypertension. It is quite well established that hypertension causes several changes in the heart metabolism, but it is still unknown whether the ECS affects this process. Therefore, we investigated the influence of prolonged ECS activation on myocardial lipid metabolism in deoxycorticosterone acetate (DOCA)-salt hypertensive rats by chronic fatty acid amide hydrolase (FAAH) inhibition...
June 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/28632318/-the-easier-the-better-preparation-of-efficient-photocatalysts-metastable-poly-heptazine-imide-salts
#3
Zupeng Chen, Aleksandr Savateev, Sergey Pronkin, Vasiliki Papaefthimiou, Christian Wolff, Marc Georg Willinger, Elena Willinger, Dieter Neher, Markus Antonietti, Dariya Dontsova
Cost-efficient, visible-light-driven hydrogen production from water is an attractive potential source of clean, sustainable fuel. Here, it is shown that thermal solid state reactions of traditional carbon nitride precursors (cyanamide, melamine) with NaCl, KCl, or CsCl are a cheap and straightforward way to prepare poly(heptazine imide) alkali metal salts, whose thermodynamic stability decreases upon the increase of the metal atom size. The chemical structure of the prepared salts is confirmed by the results of X-ray photoelectron and infrared spectroscopies, powder X-ray diffraction and electron microscopy studies, and, in the case of sodium poly(heptazine imide), additionally by atomic pair distribution function analysis and 2D powder X-ray diffraction pattern simulations...
June 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28631933/a-salt-reduction-smartphone-app-supports-lower-salt-food-purchases-for-people-with-cardiovascular-disease-findings-from-the-saltswitch-randomised-controlled-trial
#4
Helen Eyles, Rebecca McLean, Bruce Neal, Yannan Jiang, Robert N Doughty, Rachael McLean, Cliona Ni Mhurchu
Background SaltSwitch is an innovative smartphone application (app) that enables shoppers to scan the barcode of a packaged food and receive an immediate, interpretive, traffic light nutrition label on the screen, along with suggestions for lower salt alternatives. Our aim was to determine the effectiveness of SaltSwitch to support people with cardiovascular disease to make lower salt food choices. Design Six-week, two-arm, parallel, randomised controlled trial in Auckland, New Zealand (2 weeks baseline and 4 weeks intervention)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28629518/analysis-of-the-asymmetry-of-activated-epo-receptor-enables-designing-small-molecule-agonists
#5
Frank Guarnieri
Amgen solved the high-resolution cocrystal structure of erythropoietin (EPO) bound to the extracellular part of the receptor (EPOR) in 1998, which reveals that the EPO-EPOR interaction surface is formed by 11 salt bridges, 17 H-bonds, and 2 hydrophobic clusters centered at a pair of crucial phenylalanines (F93). The EPOR has two domains, one that penetrates the membrane and a second extracellular domain that forms one arm of the binding site for the EPO ligand. The complete competent receptor-binding site is a homodimer of EPOR with the two arms forming a funnel-shaped cup where EPO binds...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28627895/electroanalytical-assessment-of-the-effect-of-ni-fe-stoichiometry-and-architectural-expression-on-the-bifunctional-activity-of-nanoscale-niyfe1-yox
#6
Jesse S Ko, Christopher N Chervin, Mallory N Vila, Paul A DeSario, Joseph F Parker, Jeffrey W Long, Debra R Rolison
Electrocatalysis of the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) was assessed for a series of Ni-substituted ferrites (NiyFe1-yOx, where y = 0.1 to 0.9) as expressed in porous, high-surface-area forms (ambigel and aerogel nanoarchitectures). We then correlate electrocatalytic activity with Ni:Fe stoichiometry as a function of surface area, crystallite size, and free volume. In order to ensure in-series comparisons, calcination at 350 °C/air was necessary to crystallize the respective NiyFe1-yOx nanoarchitectures, which index to the inverse spinel structure for Fe-rich materials (y ≤ 0...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28622622/characterization-of-drug-load-variants-in-a-thiol-linked-antibody-drug-conjugate-using-multidimensional-chromatography
#7
Jonathan J Gilroy, Catherine M Eakin
The biological complexity associated with biotherapeutics such as antibody-drug conjugates (ADCs) requires extensive characterization to ensure product quality consistency, safety, and efficacy. ADCs generated via partial reduction of antibody interchain disulfide bonds result in a distribution of variants containing 0-8 conjugated drugs. Hydrophobic interaction chromatography (HIC) is a key analytical technique used to separate drug load variants of thiol linked ADCs and to calculate the average drug-to-antibody molar ratio (DAR)...
June 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28622088/engineering-osteoinductive-biomaterials-by-bioinspired-synthesis-of-apatite-coatings-on-collagen-hydrogels-with-varied-pore-microarchitectures
#8
Jacqueline Lorraine Harding, Matthew Osmond, Melissa Diane Krebs
Biomaterial controlled osteoinduction is influenced by the porous microenvironment and the composition of incorporated calcium orthophosphate (CaPi) polymorphs, however for the design of materials that rival the efficacies of natural grafts a systematic approach to assessing the physicochemical properties that affects cellular differentiation is needed. In this research, we introduce a bioinspired synthetic approach to the mineralization of preformed porous collagen hydrogel scaffolds with tunable apatite coatings...
June 16, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28619386/a-novel-17%C3%AE-hydroxysteroid-dehydrogenase-in-rhodococcus-sp-p14-for-transforming-17%C3%AE-estradiol-to-estrone
#9
Xueying Ye, Hui Wang, Jie Kan, Jin Li, Tongwang Huang, Guangming Xiong, Zhong Hu
17β-hydroxysteroid dehydrogenases (17β-HSD) are a group of oxidoreductase enzymes that exhibit high specificity for 17C reduction/oxidation. However, the mechanism of 17β-HSD in oxidizing steroid hormone 17β-estradiol to estrone in bacterium is still unclear. In this work, a functional bacterium Rhodococcus sp. P14 was identified having rapid ability to oxidize estradiol into estrone in mineral salt medium (MSM) within 6 h. The functional genes encoding NADH-dependent oxidoreductase were successfully detected with the help of bioinformatics, and it was identified that it contained two consensus regions affiliated to the short-chain dehydrogenase/reductase (SDR) superfamily...
June 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28616686/mechanistic-approach-for-fabrication-of-gold-nanoparticles-by-nitzschia%C3%A2-diatom-and-their%C3%A2-antibacterial-activity
#10
Hemant P Borase, Chandrashekhar D Patil, Rahul K Suryawanshi, Sunil H Koli, Bhavana V Mohite, Giovanni Benelli, Satish V Patil
The problem of chemically synthesized nanoproducts motivated scientific community to explore ecofriendly methods of nanosynthesis. Diatoms belong to a group of aquatic, unicellular, photosynthetic microalgae have been scarcely investigated as a source of reducing and capping agents for nanosynthesis of pesticides and antibiotics. The present study reports a novel ecofriendly method for the fabrication of bioactive gold nanoparticles using locally isolated Nitzschia diatoms. The diatom-fabricated gold nanoparticles show characteristic ruby red colored with sharp absorbance peak at 529 nm...
June 14, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28611865/dietary-modification-trial-in-community-dwelling-japanese-elderly-a-pilot-study
#11
Chika Momoki, Taeko Tsuji, Yukina Shikata, Hana Urade, Hideki Morimoto, Shinya Nakajima, Daiki Habu
BACKGROUND: This study examined the effects of 6-month nutrition education programs for community-dwelling elderly. METHODS: This study enrolled 50 community-dwelling elderly who regularly visit outpatient clinics. The programs had three goals: salt reduction, increase in dietary fiber, and adequate protein intake. Since it would be difficult for elderly to achieve all goals concurrently, a single goal was chosen by participants themselves. Anthropometric measurements, blood sampling, and assessment of dietary intake were performed at baseline, 3 months, and 6 months...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28603854/gold-redox-catalysis-through-base-initiated-diazonium-decomposition-toward-alkene-alkyne-and-allene-activation
#12
Xiaodong Shi, Boliang Dong, Haihui Peng, Stephen Motika
The discovery of photo-assisted diazonium activation toward gold(I) oxidation greatly extended the scope of gold redox catalysis by avoiding the use of a strong oxidant. Some practical issues that limit the application of this new type of chemistry are the relative low efficiency (long reaction time and low conversion) and the strict reaction condition control that is necessary (degassing and inert reaction environment). Herein, an alternative photo-free condition has been developed through Lewis base induced diazonium activation...
June 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28601769/simultaneous-removal-of-organic-matter-and-salt-ions-from-coal-gasification-wastewater-ro-concentrate-and-microorganisms-succession-in-a-mbr
#13
Shengyong Jia, Yuxing Han, Haifeng Zhuang, Hongjun Han, Kun Li
A lab-scale membrane bioreactor (MBR) with intermittent aeration was operated to treat the reverse osmosis concentrate derived from coal gasification wastewater. Results showed intermittent aeration represented slight effect on organic matter reduction but significant effect on nitrite and nitrate reduction, with 6h aeration and 6h non-aeration, removal efficiencies of organic matter, chloride, sulfate, nitrite and nitrate reached 48.35%, 40.91%, 34.28%, -36.05% and 64.34%, respectively. High-throughput sequencing showed a microorganisms succession from inoculated activated sludge (S1) to activated sludge in MBR (S2) with high salinity...
May 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28600736/blood-pressure-management-in-children-on-dialysis
#14
F Paglialonga, S Consolo, A Edefonti, G Montini
Hypertension is a leading cause of cardiovascular complications in children on dialysis. Volume overload and activation of the renin-angiotensin-aldosterone system play a major role in the pathophysiology of hypertension. The first step in managing blood pressure (BP) is the careful assessment of ambulatory BP monitoring. Volume control is essential and should start with the accurate identification of dry weight, based on a comprehensive assessment, including bioimpedance analysis and intradialytic blood volume monitoring (BVM)...
June 9, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28600315/rna-based-amplicon-sequencing-highlights-the-impact-of-the-processing-technology-on-microbiota-composition-of-artisanal-and-industrial-pdo-lard-d-arnad
#15
Ilario Ferrocino, Alberto Bellio, Angelo Romano, Guerrino Macori, Kalliopi Rantsiou, Lucia Decastelli, Luca Cocolin
"Valle d'Aosta Lard d'Arnad" is a protected designation of origin (PDO) product produced from fat of the shoulder and back of heavy pigs. Its manufacturing process can be very diverse, especially regarding the maturation temperature and the NaCl concentrationused for the brine, thereby the main goal of this study was to investigate the impact of those parameters on the microbiota developed during curing and ripening. Three farms producing Lard d'Arnad were selected. Two plants, reflecting the industrial process characterized either by low maturation temperature (plant A [10% NaCl; 2°C]) or by using a low NaCl concentrations (plant B [2...
June 9, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28599172/influence-of-sodium-chloride-reduction-and-replacement-with-potassium-chloride-based-salts-on-the-sensory-and-physico-chemical-characteristics-of-pork-sausage-patties
#16
Regan E Stanley, Chad G Bower, Gary A Sullivan
This study evaluated the effects of sodium chloride reduction and replacement with potassium chloride or modified potassium chloride based salts using a weight or molar equivalent basis on the sensory and physico-chemical properties of pork sausage patties. Three independent replications of pork sausage patties were manufactured to compare five treatments: full sodium, reduced sodium, modified potassium chloride weight based replacement, modified potassium chloride molar based replacement, and standard potassium chloride weight based replacement...
May 31, 2017: Meat Science
https://www.readbyqxmd.com/read/28597437/salt-tolerance-of-a-wild-ecotype-of-vetiver-grass-vetiveria-zizanioides-l-in-southern-china
#17
Wan-Gou Liu, Jin-Xiang Liu, Mei-Ling Yao, Qi-Fu Ma
BACKGROUND: Vetiver grass (Vetiveria zizanioides L.) is widely used in more than 120 countries for land management (e.g. rehabilitation of saline lands). A wild ecotype of vetiver grass was found in southern China in the 1950s, but little is known about its adaptability to saline stress. For the purpose of understanding its tolerance to salinity as well as corresponding tolerance mechanisms, in a greenhouse with natural lighting, seedlings were grown in culture solutions and subjected to a range of NaCl concentrations for 18 days...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28595556/iodine-prophylaxis-in-the-lights-of-the-last-recommendation-of-who-on-reduction-of-daily-salt-intake
#18
Szybiński Zbigniew
In 1994 international organizations: WHO,UNICEF and ICCIDD indicated salt - Natrium Chloride as a main carrier of iodine in the prophilaxis systems in the iodine deficient areas over the world. Following this recommendation 24 European countries introduced the model of iodine prophylaxis based on the salt iodization. However in 7 European countries only - among them in Poland - salt iodization is mandatory -as the most effective model on the population level. OBJECTIVE: Presentation the method for reduction of the consumption of iodized salt and supplementation of iodine by other iodine carriers...
June 8, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28595525/obesity-induced-hypertension-new-insights
#19
Christina Antza, Stella Stabouli, Michalis Natsis, Ioannis Doundoulakis, Vasilios Kotsis
BACKGROUND: New insights on the relationship between weight loss and hypertension and the role of the newly approved anti-obesity drugs on hypertension will be discussed Methods: Weight loss is a major factor to reduce blood pressure when a patient with excess weight is advised from the health care provider to change his lifestyle. A healthy lifestyle with reduction in body weight, reduction in caloric intake, increased fruit and vegetables consumption and reduced salt intake concomitant with an increase in physical exercise can reduce body weight and hypertension in overweight and obese patients, but not all obese are able to reduce their blood pressure and lose weight without treatment and special dietary care...
June 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28594849/high-sodium-diet-converts-renal-proteoglycans-into-pro-inflammatory-mediators-in-rats
#20
Ryanne S Hijmans, Pragyi Shrestha, Kwaku A Sarpong, Saleh Yazdani, Rana El Masri, Wilhelmina H A de Jong, Gerjan Navis, Romain R Vivès, Jacob van den Born
BACKGROUND: High dietary sodium aggravates renal disease by affecting blood pressure and by its recently shown pro-inflammatory and pro-fibrotic effects. Moreover, pro-inflammatory modification of renal heparan sulfate (HS) can induce tissue remodeling. We aim to investigate if high sodium intake in normotensive rats converts renal HS into a pro-inflammatory phenotype, able to bind more sodium and orchestrate inflammation, fibrosis and lymphangiogenesis. METHODS: Wistar rats received a normal diet for 4 weeks, or 8% NaCl diet for 2 or 4 weeks...
2017: PloS One
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