Alejandra Rodríguez, Luis Gonzalez, Arthur Ko, Marcus Alvarez, Zong Miao, Yash Bhagat, Elina Nikkola, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Linda L Muñoz-Hernández, Maria-Luisa Ordóñez-Sánchez, Rosario Rodriguez-Guillen, Karen L Mohlke, Markku Laakso, Teresa Tusie-Luna, Carlos A Aguilar-Salinas, Päivi Pajukanta
OBJECTIVE: We recently identified a locus on chromosome 18q11.2 for high serum triglycerides in Mexicans. We hypothesize that the lead genome-wide association study single-nucleotide polymorphism rs9949617, or its linkage disequilibrium proxies, regulates 1 of the 5 genes in the triglyceride-associated region. APPROACH AND RESULTS: We performed a linkage disequilibrium analysis and found 9 additional variants in linkage disequilibrium (r(2)>0.7) with the lead single-nucleotide polymorphism...
July 2016: Arteriosclerosis, Thrombosis, and Vascular Biology