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hypertrophic obstructive cardiomyopathy

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https://www.readbyqxmd.com/read/28174411/-primary-lung-cancer-associated-with-dilated-phase-of-hypertrophic-cardiomyopathy-report-of-a-case
#1
Takehiro Sakai, Takao Tsushima, Daisuke Kimura, Ryo Hatanaka, Masahiro Sawada, Yutaka Sato
A 66-year-old man diagnosed as dilated phase of hypertrophic cardiomyopathy (D-HCM) was pointed out an abnormal shadow on routine chest radiography. The patient had past medical history of hypertension, congestive heart failure and chronic obstructive pulmonary disease. The computed tomography showed a 3.8 cm-sized tumor in the left lower lobe of the lung, and histopathological examination revealed squamous cell carcinoma (cT2aN0-1M0, cStage I B-II A). Cardiosonography showed diffuse hypokinesis from basal to mid area, and ejection fraction was 36...
February 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28164017/alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy-in-a-patient-with-a-chronic-total-occlusion-of-the-right-coronary-artery-beware-of-collateral-damage
#2
Quentin de Hemptinne, Fabien Picard, Philippe L L'Allier
Alcohol septal ablation (ASA) is an effective semi-invasive alternative to surgical myectomy in selected patients for the management of severely symptomatic and drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). One contraindication of this procedure is the presence of collateral flow originating from the target septal perforator to a remote myocardial territory. In such circumstances, ethanol injection could cause remote non-target myocardial necrosis in the collateralized territory. Percutaneous revascularization of the collateralized vessel prior to ASA might cope with this contraindication by restoring normal antegrade flow in the occluded artery...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28149847/does-relief-of-outflow-tract-obstruction-in-patients-with-hypertrophic-cardiomyopathy-improve-long-term-survival-implications-for-lowering-the-threshold-for-surgical-myectomy-and-alcohol-septal-ablation
#3
EDITORIAL
Srihari S Naidu, Julio A Panza, David Spielvogel, Ramin Malekan, Joshua Goldberg, Wilbert S Aronow
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28143616/hypertrophic-obstructive-cardiomyopathy-with-multiple-coronary-arteries-to-right-ventricular-microfistulas-a-case-report-and-review-of-the-literature
#4
Daulat Singh Meena, Chandra Bhan Meena, Javed Parvez
BACKGROUND: Coronary artery microfistulas are a rare anomaly; their association with hypertrophic cardiomyopathy is even rarer and can lead to serious cardiac complications owing to coronary steal phenomena such as angina pectoris, myocardial infarction, congestive heart failure, ventricular and supraventricular arrhythmias, syncope, and sudden death. CASE PRESENTATION: A 32-year-old Indian woman presented to our institute with severe angina on exertion and multiple episodes of pre-syncope...
January 31, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28130861/an-assessment-of-left-atrial-function-in-patients-with-hypertrophic-obstructive-cardiomyopathy-before-and-1%C3%A2-year-after-septal-ablation-by-two-dimensional-speckle-tracking-echocardiography
#5
Hui Fang, Hailin Tang, Peng Li, Li Xiong, Gongpai Hu, Li Li, Yonghong Yu, Bowen Zhao
OBJECTIVE: The objective of this study was to assess left atrial (LA) function with two-dimensional speckle tracking echocardiography (2DSTE) in addition to standard echocardiographic assessments in patients with hypertrophic obstructive cardiomyopathy (HOCM) before and 1 year after septal ablation (SA). METHODS: The study included 31 patients with HOCM, who underwent SA. Each patient with HOCM underwent a complete two-dimensional transthoracic echocardiography before and 1 year after the SA...
January 28, 2017: Echocardiography
https://www.readbyqxmd.com/read/28106021/endocardial-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#6
Tolga Aksu, Tümer Erdem Güler, Kıvanç Yalın, Şükriye Ebru Gölcük, Kazım Serhan Özcan
Septal reduction therapy (SRT) is the accepted therapeutic option for symptomatic hypertrophic obstructive cardiomyopathy (HOCM). At this time, surgical septal myectomy is the gold standard method, but alcohol septal ablation is an acceptable alternative treatment for patients with suitable anatomy. Endocardial septal ablation (ESA) therapy is a little-known method of SRT. Presently described is case of successful ESA procedure performed for HOCM.
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28096824/extended-myectomy-in-the-treatment-of-patients-with-hypertrophic-obstructive-cardiomyopathy
#7
Mateusz Kuć, Piotr Kołsut, Jacek Różański, Maciej Dąbrowski, Mariusz Kłopotowski, Magda Kumor, Mirosław Kowalski, Natalia Kopyłowska, Jarosław Kuriata, Mariusz Kuśmierczyk
INTRODUCTION: Partial resection of the septal muscle is a well-established and effective method of surgical treatment for patients with hypertrophic obstructive cardiomyopathy (HOCM). The procedure is characterized by a low operative mortality rate and long-term clinical improvement that has been confirmed in numerous publications. Mitral insufficiency in patients with HOCM is mostly functional due to the effect of systolic anterior motion (SAM). AIM: To present the early results of surgical treatment provided to HOCM patients and to compare the effectiveness of two surgical procedures: isolated myectomy and myectomy combined with mitral valve replacement...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28095388/the-use-of-mitraclip-for-symptomatic-patients-with-hypertrophic-obstructive-cardiomyopathy
#8
Felix Thomas, Florian Rader, Robert J Siegel
OBJECTIVES: Current nonpharmacological therapies for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM), including septal myectomy and alcohol septal ablation (ASA), carry significant risks for serious cardiac conduction abnormalities. We present a review of the currently available published data regarding the novel use of the relatively low-risk MitraClip® system in the treatment of symptomatic patients. METHODS: Data were collected from 4 separate studies on the use of the MitraClip on 15 symptomatic HOCM patients with systolic anterior motion (SAM) of the mitral valve apparatus...
January 18, 2017: Cardiology
https://www.readbyqxmd.com/read/28072930/left-ventricular-outflow-tract-obstruction-be-prepared
#9
J S Evans, S J Huang, A S McLean, M Nalos
The current trend to treat hypotension in critically ill patients is to place a greater emphasis on inotropic support and less on fluid resuscitation in order to limit the potential harm from fluid overload. This combination may trigger left ventricular outflow tract obstruction (LVOTO) in susceptible patients. Although LVOTO is classically described in patients with hypertrophic cardiomyopathy it has been reported in other conditions including septic shock, apical ballooning syndrome, myocardial infarction, respiratory failure, and post valvular surgery...
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28070839/-1-h-and-31-p-myocardial-magnetic-resonance-spectroscopy-in-non-obstructive-hypertrophic-cardiomyopathy-patients-and-competitive-athletes
#10
Francesco Secchi, Giovanni Di Leo, Marcello Petrini, Riccardo Spairani, Marco Alì, Marco Guazzi, Francesco Sardanelli
PURPOSE: The clinical differentiation between athlete's heart and mild forms of non-obstructive hypertrophic cardiomyopathy (HCM) is crucial. We hypothesized that differences do exist between the myocardial metabolism of patients with non-obstructive HCM and competitive athletes (CAs). Our aim was to evaluate myocardial metabolism with (31)P-MRS and (1)H-MRS in HCM patients and CAs. MATERIALS AND METHODS: After Ethics Committee approval, 15 CAs and 7 HCM patients were prospectively enrolled...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28068798/an-asymptomatic-septal-perforator-coronary-artery-left-ventricle-fistula-following-myectomy-in-a-patient-with-obstructive-hypertrophic-cardiomyopathy
#11
N Koutsogiannis, Ioanna Koniari, N Kounis, G Hahalis
No abstract text is available yet for this article.
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28056231/-efficacy-comparison-between-conservative-therapy-and-septal-ablation-in-patients-with-hypertrophic-obstructive-cardiomyopathy
#12
H Zhao, J Q He, B Jiang, Y C Gao, Q Li, C Y Wu, T Y Jiang
Objective: To compare the effects of septal ablation (SA) versus conservative medication (CM) on the hemodynamic, clinical status and survival in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods: This retrospective study included 350 consecutive patients with HOCM (mean age (51.3±13.5) years old) hospitalized in Anzhen Hospital between September 2002 to September 2014. The patients were followed up to 14 years and the follow up rate was 99.4% (348/350). Overall and cardiac-related mortalities were compared between SA group (n=184) and CM group (n=184)...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28056230/-prevalence-of-pulmonary-hypertension-in-patients-with-hypertrophic-obstructive-cardiomyopathy-a-case-control-study
#13
X Wu, H Cui, M H Xiao, J Lu, C S Zhu, S Y Wang, X H Huang
Objective: To explore the clinical characteristics and risk factors of pulmonary hypertension (PH) in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods: A total of 301 patients admitted in Fuwai Hospital and diagnosed with HOCM were included in our study. Incidence rate and severity of PH were depicted. The study population was divided into two groups (PH group and control group), and the differences in clinical profile were elucidated. Risk factors of PH in patients with HOCM were assessed by multivariate logistic regression analysis...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28031684/myectomy-like-extended-alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#14
Denisa Jahnlová, Pavol Tomašov, Josef Veselka
Currently, two therapeutic options are available for patients with drug-resistant obstructive hypertrophic cardiomyopathy. While there is a tendency in extended myectomy to perform a larger septal reduction to eliminate left ventricular outflow tract gradient more effectively, there has been a trend in recent years toward using lower dosages of alcohol during alcohol septal ablation (ASA) to reduce the risk of arrhythmic complications. We report a case of a symptomatic patient with severe septal hypertrophy who underwent an extended ASA of three septal branches...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28025268/hypertrophic-cardiomyopathy-with-aortic-dilation-a-novel-observation
#15
Rayan Yousefzai, Anushree Agarwal, M Fuad Jan, Chi Cho, Michael Anigbogu, Kambiz Shetabi, Maharaj Singh, Michelle Bush, Shannon Treiber, Steven Port, Khawaja Afzal Ammar, Timothy E Paterick, Renuka Jain, Bijoy K Khandheria, A Jamil Tajik
AIMS: Our goal was to identify the prevalence of aortic dilation in patients with hypertrophic cardiomyopathy (HCM), the most prevalent (0.2%) heritable, genetic cardiovascular disease. Aortic dilation also represents a spectrum of familial inheritance. However, data regarding the prevalence of aortic dilation in HCM patients is lacking. METHODS AND RESULTS: This is an observational retrospective study of all patients referred to our HCM centre. Aortic dilation was defined based on recent American Society of Echocardiography and European Association of Cardiovascular Imaging published guidelines...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28024942/uncomplicated-pregnancy-in-a-patient-treated-with-alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#16
Pavol Tomasov, Roman Chmel, Marta Novackova, Josef Veselka
Pregnancy in women with hypertrophic cardiomyopathy (HCM) is associated with a slightly increased risk of maternal morbidity and mortality, as well as a higher risk of premature births. One of the risk factors complicating pregnancies in HCM is left ventricular outflow tract obstruction (LVOTO). We report a case of a symptomatic patient with HCM and LVOTO who was treated with alcohol septal ablation and then had an uncomplicated pregnancy.
October 20, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28018818/surgical-myectomy-after-failed-ablation-for-hypertrophic-obstructive-cardiomyopathy
#17
Ioannis Bougioukas, Uta Hoppe, Bernhard Danner, Friedrich A Schoendube
Background Hypertrophic cardiomyopathy is a genetic disease of the myocardial sarcolemma characterized by left ventricular hypertrophy. When obstruction to the left ventricular outflow tract is present and symptoms are refractory to medication, surgical myectomy or alcohol septal ablation is indicated. Case Description We report a case of a patient presented for myectomy due to recurrence only 1 year after alcohol ablation. Interesting findings were a firm subaortic membrane and a direct insertion of the papillary muscle into the mitral valve...
December 2016: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/28012232/sustained-ventricular-tachycardia-as-a-first-manifestation-of-hypertrophic-cardiomyopathy-with-mid-ventricular-obstruction-and-apical-aneurysm-in-an-elderly-female-patient
#18
Polychronis Dilaveris, Constantina Aggeli, Andreas Synetos, Ioannis Skiadas, Christos-Konstantinos Antoniou, Eleftherios Tsiamis, Konstantinos Gatzoulis, Ioannis Kallikazaros, Dimitrios Tousoulis
Sustained ventricular tachycardia complicating left ventricular apical aneurysms has been reported previously solely in middle-aged patients with hypertrophic cardiomyopathy and mid-cavity obstruction. We report a case of an elderly female patient who presented with incessant ventricular tachycardia as the first clinical manifestation of hypertrophic cardiomyopathy with mid-ventricular obstruction and apical aneurysm.
December 24, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28002430/a-novel-hras-mutation-independently-contributes-to-left-ventricular-hypertrophy-in-a-family-with-a-known-myh7-mutation
#19
Maria Elena Sana, Lawrence A Quilliam, Andrea Spitaleri, Laura Pezzoli, Daniela Marchetti, Chiara Lodrini, Elisabetta Candiago, Anna Rita Lincesso, Paolo Ferrazzi, Maria Iascone
Several genetic conditions can lead to left ventricular hypertrophy (LVH). Among them, hypertrophic cardiomyopathy (HCM), caused by mutations in sarcomere genes, is the most common inherited cardiac disease. Instead, RASopathies, a rare class of disorders characterized by neuro-cardio-facial-cutaneous abnormalities and sometimes presenting with LVH, are caused by mutations in the RAS-MAPK pathway. We report on a 62-years-old male who presented isolated severe obstructive LVH but did not carry the sarcomere mutation previously identified in his affected relatives...
2016: PloS One
https://www.readbyqxmd.com/read/27973580/a-small-molecule-inhibitor-of-sarcomere-contractility-acutely-relieves-left-ventricular-outflow-tract-obstruction-in-feline-hypertrophic-cardiomyopathy
#20
Joshua A Stern, Svetlana Markova, Yu Ueda, Jae B Kim, Peter J Pascoe, Marc J Evanchik, Eric M Green, Samantha P Harris
Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle characterized by otherwise unexplained thickening of the left ventricle. Left ventricular outflow tract (LVOT) obstruction is present in approximately two-thirds of patients and substantially increases the risk of disease complications. Invasive treatment with septal myectomy or alcohol septal ablation can improve symptoms and functional status, but currently available drugs for reducing obstruction have pleiotropic effects and variable therapeutic responses...
2016: PloS One
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