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hypertrophic obstructive cardiomyopathy

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https://www.readbyqxmd.com/read/29679534/determinants-of-reverse-remodeling-of-the-left-atrium-following-transaortic-myectomy
#1
Anita Nguyen, Hartzell V Schaff, Rick A Nishimura, Joseph A Dearani, Jeffrey B Geske, Brian D Lahr, Steve R Ommen
BACKGROUND: In patients with hypertrophic cardiomyopathy (HCM), enlargement of the left atrium (LA) is associated with increased morbidity and mortality due to risk of atrial fibrillation (AF), stroke, and heart failure. In this study, we investigated whether LA reverse remodeling occurs following septal myectomy. METHODS: Between March 2007 and July 2015, 656 patients underwent myectomy at our institution and had pre- and postoperative transthoracic echocardiographic (TTE) recording of LA volume index (LAVI)...
April 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29678624/autonomic-cardiovascular-control-and-cardiac-arrhythmia-in-two-pregnant-women-with-hypertrophic-cardiomyopathy-insights-from-icd-monitoring
#2
Pietro Francia, Carmen Adduci, Beatrice Musumeci, Lorenzo Semprini, Francesca Palano, Luigi Zezza, Massimo Volpe, Camillo Autore
In women with hypertrophic cardiomyopathy (HCM), pregnancy prompts major changes in hemodynamic and cardiac autonomic function that may precipitate heart failure (HF) or increase the risk of cardiac arrhythmia. We report the clinical follow-up of two patients with non-obstructive HCM implanted with a cardioverter defibrillator (ICD) allowing for continuous analysis of heart rate (HR), heart rate variability (HRV) and cardiac arrhythmia throughout the entire course of pregnancy. Both patients experienced increased HR and decreased HRV from the early stages of pregnancy, which persisted until delivery...
April 17, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29667903/posterior-mitral-leaflet-plication-for-hypertrophic-obstructive-cardiomyopathy
#3
Praveen Kerala Varma, Neethu Krishna, Hisham Ahamed, Sujatha Madassery
Anomalies of the mitral valve apparatus in hypertrophic cardiomyopathy are an important cause of systolic anterior motion. Patients with significant residual obstruction due to systolic anterior motion after myectomy and anterior mitral leaflet plication may end up having mitral valve replacement. We describe the case of a 52-year-old man who underwent posterior mitral leaflet plication to correct residual systolic anterior motion after anterior mitral leaflet plication.
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29660848/international-collaborative-study-to-assess-cardiovascular-risk-and-evaluate-long-term-health-in-cats-with-preclinical-hypertrophic-cardiomyopathy-and-apparently-healthy-cats-the-reveal-study
#4
Philip R Fox, Bruce W Keene, Kenneth Lamb, Karsten A Schober, Valerie Chetboul, Virginia Luis Fuentes, Gerhard Wess, Jessie Rose Payne, Daniel F Hogan, Alison Motsinger-Reif, Jens Häggström, Emilie Trehiou-Sechi, Deborah M Fine-Ferreira, Reid K Nakamura, Pamela M Lee, Manreet K Singh, Wendy A Ware, Jonathan A Abbott, Geoffrey Culshaw, Sabine Riesen, Michele Borgarelli, Michael B Lesser, Nicole Van Israël, Etienne Côté, John E Rush, Barret Bulmer, Roberto A Santilli, Andrea C Vollmar, Maribeth J Bossbaly, Nadine Quick, Claudio Bussadori, Janice M Bright, Amara H Estrada, Dan G Ohad, Maria Josefa Fernández-Del Palacio, Jenifer Lunney Brayley, Denise S Schwartz, Christina M Bové, Sonya G Gordon, Seung Woo Jung, Paola Brambilla, N Sydney Moïse, Christopher D Stauthammer, Rebecca L Stepien, Cecilia Quintavalla, Christophe Amberger, Ferenc Manczur, Yong-Wei Hung, Remo Lobetti, Marie De Swarte, Alice Tamborini, Carmel T Mooney, Mark A Oyama, Andrey Komolov, Yoko Fujii, Romain Pariaut, Masami Uechi, Victoria Yukie Tachika Ohara
BACKGROUND: Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved. HYPOTHESIS/OBJECTIVES: Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH). ANIMALS: One thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH)...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29660794/diagnostic-utility-of-cardiac-troponin-i-in-cats-with-hypertrophic-cardiomyopathy
#5
Yasutomo Hori, Masayuki Iguchi, Yasuhiro Heishima, Yohei Yamashita, Kensuke Nakamura, Atsushi Hirakawa, Akihito Kitade, Toshiki Ibaragi, Michio Katagi, Tamotsu Sawada, Masashi Yuki, Nobuyuki Kanno, Haruki Inaba, Noriko Isayama, Hideyuki Onodera, Naoki Iwasa, Mikio Kino, Mikihiro Narukawa, Syuhei Uchida
BACKGROUND: Cardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats. OBJECTIVE: To measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM. ANIMALS: Clinically healthy cats (n = 88) and cats with HCM (n = 93). METHODS: Multicenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29657309/advanced-hypertrophic-obstructive-cardiomyopathy-diagnosed-in-early-pregnancy-successful-prevention-of-sudden-cardiac-death
#6
Janusz Kudlicki, Agata Frania-Baryluk, Anna Kania, Andrzej Tomaszewski, Andrzej Wysokiński, Elżbieta Czekajska-Chehab
No abstract text is available yet for this article.
April 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29655825/hypertrophic-cardiomyopathy-clinical-update
#7
REVIEW
Jeffrey B Geske, Steve R Ommen, Bernard J Gersh
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy, manifesting as left ventricular hypertrophy in the absence of a secondary cause. The genetic underpinnings of HCM arise largely from mutations of sarcomeric proteins; however, the specific underlying mutation often remains undetermined. Patient presentation is phenotypically diverse, ranging from asymptomatic to heart failure or sudden cardiac death. Left ventricular hypertrophy and abnormal ventricular configuration result in dynamic left ventricular outflow obstruction in most patients...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29644236/hypertrophic-cardiomyopathy-with-a-large-apical-ventricular-aneurysm-and-mural-thrombus
#8
Munis Raza, Nagib Chalfoun, Abdallah Wissam, Hamza Hashmi, Richard McNamara
Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular wall thickness in the absence of any other identifiable cause of thickness. It predisposes the patient to increased risk of sudden cardiac death (SCD) due to fatal arrhythmias. Approximately 2% of the HCM patients have left ventricular apical aneurysm. CMR imaging is better in identifying this apical aneurysm as compared to echocardiogram. This apical aneurysm, which can be akinetic or dyskinetic, increases the risk of disease-related adverse events as compared to general HCM...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29628474/preoperative-simulation-using-ct-virtual-endoscopy-for-minimally-invasive-surgery-of-hypertrophic-obstructive-cardiomyopathy
#9
Toshinori Totsugawa, Masatoshi Tsunoda, Nobuyuki Kagiyama, Yuki Otsuki, Hidenori Yoshitaka, Taichi Sakaguchi
Transaortic septal myectomy is a procedure that involves a learning curve for surgeons because the bulging interventricular septum usually interferes with the visualization of the deep parts of the left ventricular chamber. In this case report, we demonstrate computed tomography virtual endoscopy for preoperative simulation, which enabled us to clearly image the relationship among the bulging septum, the expected myectomy area, and the structures deep in the left ventricle, such as the papillary muscle and abnormal muscular bundles, which are hidden by the hypertrophic septum, thus preventing visualization...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29619340/takotsubo-cardiomyopathy-with-basal-hypertrophy-and-outflow-obstruction-in-a-patient-with-bowel-ischemia
#10
Ahmad Abuarqoub, Rana Garis, Hamid Shaaban, Ibrahim Khaddash, Fayez Shamoon
Basal septal hypertrophy is a rare and unique anatomical finding associated with hypertrophic cardiomyopathy (HCM). It is also described as a sigmoid hypertrophy and is linked with aging and chronic hypertension. Takotsubo cardiomyopathy is a transient cardiomyopathy that occurs during periods of high physical or emotional stress. Its occurrence with HCM is relatively common; however, this presentation occurs more often with the classic asymmetrical septal hypertrophy or the apical variant. This case demonstrates its coexistence with isolated sigmoid hypertrophy in an elderly, hypertensive female with severe ischemic bowel disease...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29607159/application-of-3d-printing-in-the-surgical-planning-of-hypertrophic-obstructive-cardiomyopathy-and-physician-patient-communication-a-preliminary-study
#11
Hong-Chang Guo, Yang Wang, Jiang Dai, Chang-Wei Ren, Jin-Hua Li, Yong-Qiang Lai
Background: The aim of this study was to evaluate the effect of 3-dimensional (3D) printing in treatment of hypertrophic obstructive cardiomyopathy (HOCM) and its roles in doctor-patient communication. Methods: 3D-printed models were constructed preoperatively and postoperatively in seven HOCM patients received surgical treatment. Based on multi-slice computed tomography (CT) images, regions of disorder were segmented using the Mimics 19.0 software (Materialise, Leuven, Belgium)...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29604289/effect-of-spironolactone-on-myocardial-fibrosis-and-other-clinical-variables-in-patients-with-hypertrophic-cardiomyopathy-a-prospective-randomized-trial
#12
Martin S Maron, Raymond H Chan, Navin Kapur, Iris J Jaffe, Adam P McGraw, Raj Kerur, Barry J Maron, James E Udelson
BACKGROUND: Myocardial fibrosis has proved to be an important marker and determinant in the pathogenesis of hypertrophic cardiomyopathy . In particular, scar formation, if substantial, can promote ventricular tachyarrhythmias or progressive heart failure in the absence ofleft ventricular outflow obstruction. Therefore, an intervention to mitigate myocardial fibrosis would be potentially advantageous to hypertrophic cardiomyopathy patients. METHODS: Eligible hypertrophic cardiomyopathy patients were randomized 1:1 in a prospective double-blind fashion to spironolactone 50 mg or placebo to be taken over a 12-month period...
March 28, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29602755/pathoanatomic-findings-and-treatment-during-hypertrophic-obstructive-cardiomyopathy-surgery-the-role-of-mitral-valve
#13
Giuseppe M Raffa, Giuseppe Romano, Marco Turrisi, Marco Morsolini, Giovanni Gentile, Sergio Sciacca, Alessandro Armaro, Vincenzo Stringi, Gabriella Mattiucci, Serena Magro, Fabiola Cosentino, Francesco Clemenza, Michele Pilato
BACKGROUND: To assess the role of the mitral valve apparatus (leaflets, chordae and papillary muscles, PM) in left ventricle outflow tract (LVOT) obstruction, and results of the surgical treatment for hypertrophic obstructive cardiomyopathy (HOCM). METHODS: Twenty-eight consecutive patients (58±11years, 53% female) undergoing HOCM surgery from 2007 to 2016 at our institute were retrospectively reviewed. Endpoints included the involvement of the mitral valve in LVOT obstruction, mortality, and changes in clinical and echocardiographic characteristics after HOCM surgery...
February 14, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29582881/risk-assessment-of-the-occurrence-of-sudden-death-related-to-hypertrophic-cardiomyopathy-in-dakar
#14
Simon Antoine Sarr, Boubacar Dodo, Kana Babaka, Fatou Aw, Malick Bodian, Mouhamadou Bamba Ndiaye, Adama Kane, Maboury Diao, Serigne Abdou Ba
AIM: The aim of this study was to assess of the risk of sudden death in a population of hypertrophic cardiomyopathy patients in Dakar. METHODS: This was a transverse study at the cardiology clinic of Aristide Le Dantec Hospital from January 2014 to June 2015. We used the European Society of Cardiology risk score to calculate this risk. RESULTS: The average age of patients was 53 years. Unexplained syncope was found in two patients and two others had a family history of sudden death...
January 23, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29579779/late-sodium-current-inhibitors-to-treat-exercise-induced-obstruction-in-hypertrophic-cardiomyopathy-an-in-vitro-study-in-human-myocardium
#15
Cecilia Ferrantini, Josè Manuel Pioner, Luca Mazzoni, Francesca Gentile, Benedetta Tosi, Alessandra Rossi, Luiz Belardinelli, Chiara Tesi, Chiara Palandri, Rosanna Matucci, Elisabetta Cerbai, Iacopo Olivotto, Corrado Poggesi, Alessandro Mugelli, Raffaele Coppini
BACKGROUND AND PURPOSE: In 30-40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left-ventricular (LV) outflow gradients develop only during exercise due to catecholamine-induced LV-hypercontractility (inducible obstruction). Negative-inotropic pharmacological options are limited to β-blockers or disopyramide, with scarce efficacy and tolerability. We assessed the potential use of late Na+ -current (INaL )-inhibitors to treat inducible obstruction in HCM. EXPERIMENTAL APPROACH: The electrophysiological and mechanical responses to β-adrenergic stimulation were studied in human myocardium from HCM versus control patients...
March 26, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29577420/infarction-of-the-septomarginal-band-and-tricuspid-papillary-muscle-rupture-related-to-alcohol-septal-ablation-for-hypertrophic-cardiomyopathy
#16
Munevver Sari, Cemil Izgi, Gokhan Kahveci, Alev Kilicgedik, Zubeyde Bayram, Suzan Hatipoglu, Selcuk Pala, Nihal Ozdemir
We presented a 77-year-old man with hypertrophic obstructive cardiomyopathy applied with flail tricuspid leaflet and severe tricuspid regurgitation leading to right heart failure 2 months after the failed septal ablation. The ruptured anterior tricuspid papillary muscle resulted from infarction of the base of anterior papillary muscle of the right ventricle (RV) confirmed by magnetic resonance imaging. As the septomarginal band is frequently lit up by intracoronary contrast that particular attention should be paid to the RV papillary muscles...
March 25, 2018: Echocardiography
https://www.readbyqxmd.com/read/29573929/standardized-goal-directed-valsalva-maneuver-for-assessment-of-inducible-left-ventricular-outflow-tract-obstruction-in-hypertrophic-cardiomyopathy
#17
Suwen Kumar, Grace Van Ness, Aron Bender, Mrinal Yadava, Jessica Minnier, Sriram Ravi, Lidija McGrath, Howard K Song, Stephen B Heitner
BACKGROUND: The Valsalva maneuver is widely used to provoke left ventricular outflow tract obstruction in hypertrophic cardiomyopathy (HCM). Whereas early experiments used a standardized, goal-directed approach by maintaining an intraoral pressure >40 mm Hg for >10 sec, current practice depends on patients' understanding and effort. The aim of this study was to evaluate the clinical effectiveness of the goal-directed Valsalva maneuver (GDV) in HCM as a method to provoke left ventricular outflow tract obstruction...
March 21, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29569368/optimal-reconstruction-of-left-ventricular-outflow-tract-obstruction-before-surgical-myectomy-in-a-case-with-hypertrophic-obstructive-cardiomyopathy
#18
Hiroyuki Toh, Shumpei Mori, Shinsuke Shimoyama, Yu Izawa, Shun Yokota, Yuto Shinkura, Ryo Takeshige, Akira Nagasawa, Fumitaka Soga, Hidekazu Tanaka, Toshiro Shinke, Koki Yokawa, Takashi Matsueda, Yutaka Okita, Ken-Ichi Hirata
We present optimally reconstructed three-dimensional computed tomography images of left ventricular outflow obstruction, comprehensive left ventriculography, and comparable intraoperative transesophageal echocardiography, as well as serial operative pictures, to facilitate the understanding of live-heart anatomy of hypertrophic obstructive cardiomyopathy. As shown in this case, detailed morphological analysis around the left ventricular outflow tract using preoperative computed tomography would be feasible and useful...
March 22, 2018: Echocardiography
https://www.readbyqxmd.com/read/29550522/diagnostic-value-and-prognostic-implications-of-early-cardiac-magnetic-resonance-in-survivors-of-out-of-hospital-cardiac-arrest
#19
Alessandro Zorzi, Angela Susana, Manuel De Lazzari, Federico Migliore, Giovanni Vescovo, Daniele Scarpa, Anna Baritussio, Giuseppe Tarantini, Luisa Cacciavillani, Benedetta Giorgi, Cristina Basso, Sabino Iliceto, Chiara Bucciarelli Ducci, Domenico Corrado, Martina Perazzolo Marra
BACKGROUND: In patients who survived out-of-hospital cardiac arrest (OHCA) it is crucial to establish the underlying cause and its potential reversibility. OBJECTIVE: We assessed the incremental diagnostic and prognostic role of early cardiac magnetic resonance (CMR) in survivors of OHCA. METHODS: Among 139 consecutive OHCA patients, we enrolled 44 (median age 43 years; 84% males) patients who underwent coronary angiography and CMR ≤7 days after admission...
March 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29549506/minimally-invasive-trans-mitral-septal-myectomy-for-diffuse-type-hypertrophic-obstructive-cardiomyopathy
#20
Taichi Sakaguchi, Toshinori Totsugawa, Kentaro Tamura, Arudo Hiraoka, Genta Chikazawa, Hidenori Yoshitaka
OBJECTIVE: Despite excellent long-term results reported for a trans-aortic septal myectomy for hypertrophic obstructive cardiomyopathy (HOCM), surgery for patients with diffuse hypertrophy is very challenging. In addition, a left ventricular outflow obstruction is often aggravated by an abnormal mitral valve and subvalvular apparatus. METHODS: We performed video-assisted minimally invasive trans-mitral septal myectomy procedures in 3 patients with diffuse-type HOCM, who were highly symptomatic despite maximal medical therapy...
March 16, 2018: General Thoracic and Cardiovascular Surgery
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