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hypertrophic obstructive cardiomyopathy

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https://www.readbyqxmd.com/read/28688952/left-ventricular-mechanics-in-children-with-hypertrophic-cardiomyopathy-cmr-study
#1
Łukasz Mazurkiewicz, Lidia Ziółkowska, Joanna Petryka, Mateusz Śpiewak, Łukasz Małek, Agata Kubik, Magdalena Marczak, Jolanta Misko, Grażyna Brzezińska-Rajszys
OBJECTIVES: To assess the magnitude of myocardial displacement abnormalities and their alterations with the fibrosis, left-ventricular (LV) outflow tract obstruction (LVOTO) and hypertrophy in juveniles with hypertrophic cardiomyopathy (HCM). STUDY DESIGN: Fifty-five children [age 12,5±4.6years, 38 (69,1%) males, 19 (34,5%) with LVOTO] with HCM and 20 controls underwent cardiovascular magnetic resonance. The LV feature tracking (FT) derived strain and strain rates were quantified...
July 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28688858/a-comprehensive-review-of-stress-testing-in-hypertrophic-cardiomyopathy-assessment-of-functional-capacity-identification-of-prognostic-indicators-and-detection-of-coronary-artery-disease
#2
REVIEW
Albree Tower-Rader, Jorge Betancor, Harry M Lever, Milind Y Desai
Hypertrophic cardiomyopathy is a heterogeneous condition that may present with functional limitation due to dyspnea on exertion, angina, or symptoms of heart failure. Although angina is a common symptom, it is thought to be multifactorial, including abnormal microvasculature and epicardial coronary artery disease. The role of stress testing in the detection of coronary artery disease and its limitations are discussed in this review. Stress testing yields additional information beyond the detection of ischemia, which is prognostic independent of the presence of coronary artery disease and can be beneficial in defining the presence of provocable left ventricular outflow tract obstruction, symptoms, response of heart rate and blood pressure to exercise, and functional capacity...
July 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28681495/underappreciated-occurrence-of-discrete-subaortic-membranes-producing-left-ventricular-outflow-obstruction-in-hypertrophic-cardiomyopathy
#3
Muhil Kannappan, Barry J Maron, Hassan Rastegar, Natesa G Pandian, Martin S Maron, Ethan J Rowin
Subaortic obstruction due to systolic anterior motion (SAM) of the mitral valve with ventricular septal contact is a major cause of progressive heart failure symptoms in patients with hypertrophic cardiomyopathy (HCM). However, we have recently observed a unique, but not uncommon subgroup of HCM patients with outflow tract obstruction due only to discrete subaortic membrane or who have a membrane in addition to SAM-septal contact. HCM patients with subaortic membranes may be at increased risk for developing progressive heart failure symptoms...
July 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28674779/analysis-of-three-dimensional-endocardial-and-epicardial-strains-from-cardiac-magnetic-resonance-in-healthy-subjects-and-patients-with-hypertrophic-cardiomyopathy
#4
Xiaodan Zhao, Ru San Tan, Hak Chiaw Tang, Shuang Leng, Jun-Mei Zhang, Liang Zhong
Hypertrophic cardiomyopathy (HCM) is a genetic disease that leads to left ventricle (LV) hypertrophy with or without the presence of LV outflow tract obstruction. The aim of this study was to find an easy and useful indicator based on cardiac magnetic resonance (CMR) images for control subjects and patients with and without obstruction. CMR scans were performed for 19 control subjects and 19 HCM patients. Endocardial strain was defined as [Formula: see text], with [Formula: see text] being the length of endocardium at end-diastole (end-systole); similarly for epicardial strain ([Formula: see text])...
July 3, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28670188/an-uncommon-variant-of-an-uncommon-disease-a-caucasian-adolescent-with-apical-hypertrophic-cardiomyopathy-diagnosed-with-myocardial-perfusion-imaging
#5
Rami Kassem Zein, Zaid Al-Faham, Jason A Mouabbi, Edouard R Daher
Apical hypertrophic cardiomyopathy (ApHCM) is a subtype of HCM. This variant is more common in the Asian population when compared to North American patients. Patients may present with arrhythmias, heart failure, myocardial infarction, chest discomfort, fatigue, and presyncope or syncope. Initial evaluation requires electrocardiogram and two-dimensional echocardiogram. T-wave inversion in the precordial leads as well as hypertrophy of the left ventricle is hallmarks of the disease. Cardiac magnetic resonance (CMR) imaging is the most specific and sensitive imaging modality...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28669440/electrical-storms-in-patients-with-apical-aneurysms-and-hypertrophic-cardiomyopathy-with-midventricular-obstruction-a-case-series
#6
Anita Nguyen, Hartzell V Schaff
No abstract text is available yet for this article.
June 8, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28667811/premature-ventricular-contractions-producing-brockenbrough-braunwald-sign-in-obstructive-cardiomyopathy
#7
Gaurav K Sharma, Angie Tripathi, Paul A Jones
Increased dynamic flow in hypertrophic obstructive cardiomyopathy depicts a classic sign on invasive pressure tracings of the aorta and left ventricle, simultaneously known as the Brockenbrough-Braunwald sign, which is demonstrated in the presented case.
July 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28658286/mybpc3-mutations-are-associated-with-a-reduced-super-relaxed-state-in-patients-with-hypertrophic-cardiomyopathy
#8
James W McNamara, Amy Li, Sean Lal, J Martijn Bos, Samantha P Harris, Jolanda van der Velden, Michael J Ackerman, Roger Cooke, Cristobal G Dos Remedios
The "super-relaxed state" (SRX) of myosin represents a 'reserve' of motors in the heart. Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate. Changes in the SRX are likely to modulate cardiac contractility. We previously demonstrated that the SRX is significantly reduced in mouse cardiomyocytes lacking cardiac myosin binding protein-C (cMyBP-C). Here, we report the effect of mutations in the cMyBP-C gene (MYBPC3) using samples from human patients with hypertrophic cardiomyopathy (HCM)...
2017: PloS One
https://www.readbyqxmd.com/read/28624663/role-of-exercise-electrocardiogram-to-screen-for-t-wave-oversensing-after-implantation-of-subcutaneous-implantable-cardioverter-defibrillator
#9
Muhammad R Afzal, Christopher Evenson, Auroa Badin, Dilesh Patel, Hemant Godara, Michael Essandoh, Toshimasa Okabe, Jaret Tyler, Mahmoud Houmsse, Ralph Augostini, John Hummel, Steven Kalbfleisch, Emile G Daoud, Raul Weiss
BACKGROUND: During early experience with subcutaneous implantable cardioverter-defibrillators (S-ICD), several patients had inappropriate shocks from T-wave oversensing (TWOS) during exercise. This prompted some operators to perform routine treadmill exercise tests after implantation of S-ICD to screen for TWOS. Meanwhile, improvements have been made in the detection algorithms by the manufacturer. OBJECTIVE: To assess whether routine treadmill exercise post S-ICD implantation is warranted...
June 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28602671/atrial-fibrillation-in-hypertrophic-cardiomyopathy
#10
REVIEW
Kaivan Vaidya, Christopher Semsarian, Kim H Chan
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder with a spectrum of clinical manifestations. Patients with HCM are predisposed to developing atrial fibrillation (AF) due primarily to advanced diastolic dysfunction and left atrial (LA) dilatation and remodelling. Atrial fibrillation causes a progressive symptomatic and functional decline, as well as increased thromboembolic risk and mortality, particularly in the setting of rapid ventricular rates and left ventricular outflow tract (LVOT) obstruction...
May 23, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28600085/invasive-hemodynamics-of-myocardial-disease-systolic-and-diastolic-dysfunction-and-hypertrophic-obstructive-cardiomyopathy
#11
REVIEW
Michael Eskander, Morton J Kern
Heart failure is a clinical diagnosis that is supported by various laboratory, imaging, and invasive hemodynamic measures. There is no single diagnostic test. A variety of structural and/or functional myocardial abnormalities can lead to the inability of the heart to fill or eject blood. Despite ejection fraction being the most commonly assessed measure of systolic function in clinical practice, it is a poor measure of contractility because it is susceptible to loading conditions and chamber size. Invasive hemodynamic assessment remains of great importance in the evaluation of patients with myocardial disease or hypertrophic cardiomyopathy...
July 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28597791/value-of-latent-outflow-obstruction-to-predict-clinical-course-of-patients-with-hypertrophic-cardiomyopathy
#12
Fatih Bayrak, Gokhan Kahveci, Ali Buturak, Tansu Karaahmet, Ulaankhuu Batgerel, Atilla Koyuncu, Bulent Mutlu
Objective The frequency, significance and prognostic value of left ventricle obstruction (LVO) induced with provocation (latent LVO) is controversial for hypertrophic cardiomyopathy (HC) patients. This study was designed to assess the value of latent LVO in predicting the clinical course in 101 patients with HC. Methods and results Patients were followed for a mean of 82 ± 48 months (range 2 to 148 months) for clinical end points defined as a composite of cardiovascular death resuscitated cardiac arrest, appropriate defibrillator shock or hospitalization due to worsening of heart failure symptoms...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28595881/outcomes-of-alcohol-septal-ablation-in%C3%A2-younger%C3%A2-patients-with-obstructive-hypertrophic%C3%A2-cardiomyopathy
#13
Max Liebregts, Lothar Faber, Morten K Jensen, Pieter A Vriesendorp, Jaroslav Januska, Jan Krejci, Peter R Hansen, Hubert Seggewiss, Dieter Horstkotte, Radka Adlova, Henning Bundgaard, Jurriën M Ten Berg, Josef Veselka
OBJECTIVES: The aim of this study was to describe the safety and outcomes of alcohol septal ablation (ASA) in younger patients with obstructive hypertrophic cardiomyopathy. BACKGROUND: The American College of Cardiology Foundation/American Heart Association guidelines reserve ASA for older patients and patients with serious comorbidities. Data on long-term age-specific outcomes after ASA are scarce. METHODS: A total of 1,197 patients (mean age 58 ± 14 years) underwent ASA for obstructive hypertrophic cardiomyopathy...
June 12, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28593726/the-evolution-of-basal-septal-hypertrophy-from-benign-and-age-related-normal-variant-to-potentially-obstructive-and-symptomatic-cardiomyopathy
#14
REVIEW
Anthony C Pearson
Localized thickening of the basal portion of the ventricular septum or basal septal hypertrophy (BSH) has been identified both at autopsy and by imaging studies for decades; despite numerous investigations, there is no consensus on the significance of this finding and a remarkable lack of consistency in terminology. This paper summarizes the scientific literature on the topic, focusing on recent echocardiographic findings. A case description illustrating some of the complex issues involved in measurement and diagnosis and differentiation from sigmoidal hypertrophic cardiomyopathy (HCM) is presented...
June 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/28589043/anomalous-papillary-muscle-insertion-causing-dynamic-left-ventricular-outflow-tract-obstruction-without-hypertrophic-obstructive-cardiomyopathy
#15
Ravi Korabathina, Katherine Chiu, Hugh M van Gelder, Arthur Labovitz
Anomalous papillary muscle insertion directly into the surface of the mitral valve leaflet is rare, especially in a subject without apparent evidence of hypertrophic cardiomyopathy. We present a case of this isolated congenital malformation producing two hemodynamic sequelae of dynamic left ventricular outflow tract obstruction and severe mitral regurgitation.
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28575282/mitral-valve-repair-or-replacement-in-hypertrophic-obstructive-cardiomyopathy-a-prospective-randomized-study%C3%A2
#16
Alexander Bogachev-Prokophiev, Alexander Afanasyev, Sergey Zheleznev, Michael Fomenko, Ravil Sharifulin, Eugenie Kretov, Alexander Karaskov
OBJECTIVES: The optimal surgical strategy for concomitant mitral valve intervention during myectomy remains controversial. The purpose of this study was to compare the results of mitral valve replacement versus repair in patients with hypertrophic obstructive cardiomyopathy and severe mitral regurgitation. METHODS: Between 2010 and 2013, a total of 88 patients with hypertrophic obstructive cardiomyopathy and severe mitral regurgitation were randomly assigned to undergo either mitral valve replacement or repair in addition to extended myectomy...
May 29, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28555387/ameliorating-the-severity-of-sleep-disordered-breathing-concomitant-with-heart-failure-status-after-percutaneous-transluminal-septal-myocardial-ablation-for-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#17
Keitaro Akita, Yuichiro Maekawa, Takashi Kohno, Hikaru Tsuruta, Mitsushige Murata, Keiichi Fukuda
The coexistence of sleep-disordered breathing (SDB) and hypertrophic obstructive cardiomyopathy (HOCM) has widely been recognized; however, the impact of percutaneous transluminal septal myocardial ablation (PTSMA) for HOCM on SDB remains unknown. Herein, we examine cardiorespiratory polygraph parameters in patients with drug-refractory HOCM before and after PTSMA. Forty consecutive drug-refractory HOCM patients, admitted to Keio University Hospital, and who underwent cardiorespiratory polygraphy were retrospectively analyzed...
May 29, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28550094/safety-of-outpatient-initiation-of-disopyramide-for-obstructive-hypertrophic-cardiomyopathy-patients
#18
Arnon Adler, Dana Fourey, Adaya Weissler-Snir, Waseem Hindieh, Raymond H Chan, Michael H Gollob, Harry Rakowski
BACKGROUND: Disopyramide is effective in ameliorating symptoms in patients with hypertrophic cardiomyopathy; however, its potential for proarrhythmic effect has raised concerns about its use in the ambulatory setting. The risk of initiating disopyramide in this manner has never been evaluated. METHODS AND RESULTS: All charts of patients seen in the outpatient hypertrophic cardiomyopathy clinic between 2010 and 2014 were screened for initiation of disopyramide and data were extracted...
May 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28536896/helical-distribution-of-hypertrophy-in-patients-with-hypertrophic-cardiomyopathy-prevalence-and-clinical-implications
#19
Dafne Viliani, Eduardo Pozo, Norma Aguirre, Alberto Cecconi, María J Olivera, Paloma Caballero, Luis J Jiménez-Borreguero, Fernando Alfonso
Recently a novel pattern of helical distribution of hypertrophy has been described in patients with hypertrophic cardiomyopathy (HCM). Our aim was to determine its prevalence and potential implications in an unselected cohort. One-hundred- and eight consecutive patients diagnosed with HCM by cardiac magnetic resonance (CMR) were included (median clinical follow up of 1718 days). All clinical and complementary test information was prospectively collected. The presence of a helical pattern was assessed by a simple measurement of the maximal left ventricle (LV) wall thickness (LVWT) for each of the 17 classical LV segments and it was classified in one of three types according to its extension...
May 23, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28527561/implantation-of-a-long-term-left-ventricular-assist-device-in-a-patient-with-obstructive-hypertrophic-cardiomyopathy
#20
Luis Horacio Varela-Falcón, David Dobarro, Inés Sayago, Javier López, Salvatore Di Stefano, Luis De la Fuente
No abstract text is available yet for this article.
May 17, 2017: Revista Española de Cardiología
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