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https://www.readbyqxmd.com/read/28917227/pharmacoeconomics-of-parenteral-nutrition-in-surgical-and-critically-ill-patients-receiving-structured-triglycerides-in-china
#1
Guo Hao Wu, Alexandra Ehm, Marco Bellone, Lorenzo Pradelli
BACKGROUND AND OBJECTIVES: A prior meta-analysis showed favorable metabolic effects of structured triglyceride (STG) lipid emulsions in surgical and critically ill patients compared with mixed medium-chain/long-chain triglycerides (MCT/LCT) emulsions. Limited data on clinical outcomes precluded pharmacoeconomic analysis. We performed an updated meta-analysis and developed a cost model to compare overall costs for STGs vs MCT/LCTs in Chinese hospitals. METHODS AND STUDY DESIGN: We searched Medline, Embase, Wanfang Data, the China Hospital Knowledge Database, and Google Scholar for clinical trials comparing STGs to mixed MCT/LCTs in surgical or critically ill adults published between October 10, 2013 and September 19, 2015...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28913583/economic-assessment-of-conventional-and-conservation-tillage-practices-in-different-wheat-based-cropping-systems-of-punjab-pakistan
#2
Muhammad Shahzad, Mubshar Hussain, Muhammad Farooq, Shahid Farooq, Khawar Jabran, Ahmad Nawaz
Wheat productivity and profitability is low under conventional tillage systems as they increase the production cost, soil compaction, and the weed infestation. Conservation tillage could be a pragmatic option to sustain the wheat productivity and enhance the profitability on long term basis. This study was aimed to evaluate the economics of different wheat-based cropping systems viz. fallow-wheat, rice-wheat, cotton-wheat, mung bean-wheat, and sorghum-wheat, with zero tillage, conventional tillage, deep tillage, bed sowing (60/30 cm beds and four rows), and bed sowing (90/45 cm beds and six rows)...
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28905065/be-positive-optimizing-pramlintide-from-microcanonical-analysis-of-amylin-isoforms
#3
Rafael B Frigori
Amylin, or human islet amyloid polypeptide (hIAPP), is a 37-residue hormone synergistic to insulin and co-secreted with it by β-cells in the pancreas. The deposition of its cytotoxic amyloid fibrils is strongly related to the progression of Type II diabetes (T2D) and islet graft failures. Notably, isoforms from some mammalian species, such as rats (rIAPP) and porcine (pIAPP), present a few key mutations preventing aggregation. This has lead to biotechnological development of drugs for adjunct therapies of T2D, such as pramlintide, a variant of hIAPP inspired by rIAPP whose proline substitutions have β-strand fibril-breaking properties...
September 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28903865/economic-evaluation-of-the-eradication-program-for-bovine-viral-diarrhea-in-the-swiss-dairy-sector
#4
B Thomann, A Tschopp, I Magouras, M Meylan, G Schüpbach-Regula, B Häsler
Since 2008, the Swiss veterinary service has been running a mandatory eradication program for Bovine Viral Diarrhea (BVD) that is focused on detecting and eliminating persistently infected (PI) animals. Detection was initially based on antigen testing from ear tag samples of the entire cattle population, followed by antigen testing of all newborn calves until 2012. Since then, bulk milk serology (dairy herds) and blood sample serology (beef herds) have been used for the surveillance of disease-free herds. From 2008 to 2012, the proportion of newborn PI calves decreased from 1...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28901346/-procurement-of-medical-devices-based-on-cost-effectiveness-data
#5
Sabrina Trippoli
The field of medical devices is characterized by a paucity of cost-effectiveness data that support their use. In this context, we have proposed a project based on the calculation of net monetary benefit (NMB) for each product subjected to procurement through tenders. This project consists of two steps: 1) calculation of NMB; 2) calculation of a value-based score to be used in the process of procurement and tendering. The NMB is defined as follows: NMB per patient= (monetary threshold of WTP) x (QALYs per patient) - (treatment cost per patient); WTP= willingness to pay]...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28900490/wnt3a-expression-is-associated-with-epithelial-mesenchymal-transition-and-impacts-prognosis-of-lung-adenocarcinoma-patients
#6
Jinming Xu, Wang Lv, Yeji Hu, Luming Wang, Yiqing Wang, Jinlin Cao, Jian Hu
Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to evaluate the association between Wnt3a and EMT-related proteins (E-cadherin and N-cadherin), and to further investigate its impact on prognosis of lung adenocarcinoma patients. Methods: A total of 147 lung adenocarcinoma patients were included and their clinicopathological characteristics were collected in this retrospective study...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28895243/controlling-complex-stability-in-photoresponsive-macromolecular-host-guest-systems-toward-reversible-capture-of-dna-by-cyclodextrin-vesicles
#7
Johanna Moratz, Lucas Stricker, Sabrina Engel, Bart Jan Ravoo
An effective and universal method for delivering structurally diverse biomolecules in vivo would greatly benefit modern drug therapy, but has yet to be discovered. Self-assembled supramolecular complexes containing vesicles of amphiphilic cyclodextrin and linker molecules with an azobenzene guest unit and a charged functionality have been established as nanoscale carriers for proteins and DNA, making use of multivalent electrostatic attraction. However, light-induced cargo release is only feasible up to a maximum net charge of the biomacromolecules...
September 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28893833/anticoagulation-for-nonvalvular-atrial-fibrillation-influence-of-epidemiologic-trends-and-clinical-practice-patterns-on-risk-stratification-and-net-clinical-benefit
#8
Richard W Asinger, Gautam R Shroff, Mengistu A Simegn, Charles A Herzog
No abstract text is available yet for this article.
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28892413/enhancing-the-real-world-prediction-of-cardiovascular-events-and-major-bleeding-with-the-cha2ds2-vasc-and-has-bled-scores-using-multiple-biomarkers
#9
Vanessa Roldán, José Miguel Rivera-Caravaca, Alena Shantsila, Amaya García-Fernández, María Asunción Esteve-Pastor, Juan Antonio Vilchez, Marta Romera, Mariano Valdés, Vicente Vicente, Francisco Marín, Gregory Y H Lip
BACKGROUND: Atrial fibrillation (AF)-European guidelines suggest the use of biomarkers to stratify patients for stroke and bleeding risks. We investigated if a multi-biomarker strategy improved the predictive performance of CHA2DS2-VASc and HAS-BLED in anticoagulated AF patients. METHODS: We included consecutive patients stabilized for 6 months on vitamin K antagonists (INRs 2.0-3.0). High sensitivity troponin T, N-proBNP, interleukin 6, von Willebrand factor concentrations and glomerular filtration rate (eGFR; using MDRD-4 formula) were quantified at baseline...
September 11, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28890993/chemotherapy-in-nets-when-and-how
#10
REVIEW
Anna Angelousi, Gregory Kaltsas, Anna Koumarianou, Martin O Weickert, Ashley Grossman
The majority of neuroendocrine tumours (NETs) are well-differentiated tumours that follow an indolent course, in contrast to a minority of poorly differentiated neuroendocrine carcinomas (NECs) which exhibit an aggressive course and assocaited with an overall short survival. Although surgery is the only curative treatment for NETs it is not always feasible,necessitating the application of other therapies including chemotherapy. Streptozotocin (STZ)-based regimens have long been used for advanced or metastatic well-to-moderately differentiated (G1-G2) NETs, especially those originating from the pancreas (pNETs)...
September 11, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28890151/when-to-perform-preoperative-bone-scintigraphy-for-kidney-cancer-staging-indications-for-preoperative-bone-scintigraphy
#11
Alessandro Larcher, Fabio Muttin, Nicola Fossati, Paolo Dell'Oglio, Ettore Di Trapani, Armando Stabile, Francesco Ripa, Francesco Trevisani, Cristina Carenzi, Maria Picchio, Alberto Briganti, Andrea Salonia, Alexandre Mottrie, Roberto Bertini, Francesco Montorsi, Umberto Capitanio
OBJECTIVES: To identify an objective and reproducible strategy for preoperative staging bone scintigraphy [BS] in patients diagnosed with renal cell carcinoma [RCC], since in absence of objective criteria, the decision to perform preoperative BS remains a subjective practice. METHODS: 2,008 RCC patients treated with surgery and prospectively included into an institutional database. The study outcome was presence of one or more bone lesions suspicious for metastases at staging BS...
September 7, 2017: Urology
https://www.readbyqxmd.com/read/28888284/long-term-consequences-of-youth-volunteering-voluntary-versus-involuntary-service
#12
Jinho Kim, Kerem Morgül
Despite the renewed interest in youth volunteering in recent years, there remain major gaps in our knowledge of its consequences. Drawing data from the National Longitudinal Study of Adolescent to Adult Health, we examine the long-term effects of youth volunteering on the civic and personal aspects of volunteers' lives. Our results suggest that youth volunteering has a positive return on adult volunteering only when it is voluntary, and that net of contextual factors neither voluntary nor involuntary youth service has a significant effect on adult voting...
September 2017: Social Science Research
https://www.readbyqxmd.com/read/28885858/the-latino-integrative-medical-group-visit-as-a-model-for-pain-reduction-in-underserved-spanish-speakers
#13
Oscar Cornelio-Flores, Anna Sophia Lestoquoy, Sheila Abdallah, Amanda DeLoureiro, Karla Lorente, Bryan Pardo, Joseph Olunwa, Paula Gardiner
OBJECTIVES: Chronic pain is a common problem in the United States, one for which there is a dearth of effective treatments. Nonpharmacological options are a promising alternative, especially for Spanish-speaking Latinos. This pilot study would like to assess the feasibility of an adapted Integrative Medical Group Visit (IMGV) curriculum for a Spanish-speaking Latino chronic pain population. DESIGN AND INTERVENTION: We translated and adapted the curriculum of the IMGV for a Spanish-speaking Latino chronic pain population...
September 8, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28882770/video-assisted-anal-fistula-treatment-vaaft-in-cryptoglandular-fistula-in-ano-a-systematic-review-and-proportional-meta-analysis
#14
REVIEW
Pankaj Garg, Pratiksha Singh
BACKGROUND: Video-Assisted Anal Fistula Treatment (VAAFT) is a relatively new minimally invasive videoendoscopic procedure for treating fistula-in-ano. We reviewed and performed metaanalysis to evaluate the efficacy of this procedure. METHODS: Studies from the period 2010 to 2016 were searched in PubMed, Medline, Scopus, Embase, Ovid, SCI database, Cochrane Central Register of Controlled Trials (CENTRAL) & Google Scholar database. All studies which utilized VAAFT to treat fistula-in-ano were extracted...
September 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28881951/monitoring-temporal-variation-to-assess-changes-in-the-structure-of-subtropical-atlantic-forest-butterfly-communities
#15
Cristiano Agra Iserhard, Helena Piccoli Romanowski, Aline Richter, Milton de Souza Mendonça
The study of fauna through long-term surveys is important in unveiling how temporal patterns shape the structure of communities in tropical habitats. The butterfly assemblage of the subtropical Atlantic Forest may be considered highly diverse and shows changes in diversity and composition over time, highlighting the importance of long-term inventories. This work assessed temporal diversity patterns in the distribution and composition of butterfly assemblages in an Atlantic Forest site in southern Brazil using combined data from three years of standardized sampling with entomological nets, increasing the knowledge on this group in the Neotropics for monitoring and conservation...
August 1, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28881474/assessment-of-instructions-on-protection-against-food-contaminated-with-radiocesium-in-japan-in-2011
#16
Mayumi Seto, Koichiro Uriu, Isao Kawaguchi, Hiroyuki Yokomizo
The Japan Ministry of Health, Labour and Welfare (MHLW) has published instructions for radiological protection against food after the Fukushima Daiichi nuclear power plant accident in 2011. Following the instructions, the export and consumption of food items identified as being contaminated were restricted for a certain period. We assessed the validity of the imposed restriction periods for two representative vegetables (spinach and cabbage) grown in Fukushima Prefecture from two perspectives: effectiveness for reducing dietary dose and economic efficiency...
September 7, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28877952/effectiveness-and-cost-effectiveness-of-a-cardiovascular-risk-prediction-algorithm-for-people-with-severe-mental-illness-primrose
#17
Ella Zomer, David Osborn, Irwin Nazareth, Ruth Blackburn, Alexandra Burton, Sarah Hardoon, Richard Ian Gregory Holt, Michael King, Louise Marston, Stephen Morris, Rumana Omar, Irene Petersen, Kate Walters, Rachael Maree Hunter
OBJECTIVES: To determine the cost-effectiveness of two bespoke severe mental illness (SMI)-specific risk algorithms compared with standard risk algorithms for primary cardiovascular disease (CVD) prevention in those with SMI. SETTING: Primary care setting in the UK. The analysis was from the National Health Service perspective. PARTICIPANTS: 1000 individuals with SMI from The Health Improvement Network Database, aged 30-74 years and without existing CVD, populated the model...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28875172/the-biodiversity-cost-of-carbon-sequestration-in-tropical-savanna
#18
Rodolfo C R Abreu, William A Hoffmann, Heraldo L Vasconcelos, Natashi A Pilon, Davi R Rossatto, Giselda Durigan
Tropical savannas have been increasingly viewed as an opportunity for carbon sequestration through fire suppression and afforestation, but insufficient attention has been given to the consequences for biodiversity. To evaluate the biodiversity costs of increasing carbon sequestration, we quantified changes in ecosystem carbon stocks and the associated changes in communities of plants and ants resulting from fire suppression in savannas of the Brazilian Cerrado, a global biodiversity hotspot. Fire suppression resulted in increased carbon stocks of 1...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28874893/systemic-therapy-in-incurable-gastroenteropancreatic-neuroendocrine-tumours-a-clinical-practice-guideline
#19
S Singh, D Sivajohanathan, T Asmis, C Cho, N Hammad, C Law, R Wong, K Zbuk
PURPOSE: The purpose of the present review was to determine which antineoplastic systemic therapy is most effective in improving clinical outcomes for patients with incurable gastroenteropancreatic neuroendocrine tumours (nets). METHODS: A systematic search (2008-2016) of the literature in the medline and embase databases and the Cochrane Database of Systematic Reviews was conducted; abstracts from the American Society of Clinical Oncology, the American Society of Clinical Oncology Gastrointestinal Cancers Symposium, the European Society for Medical Oncology, the European Cancer Congress, the European Neuroendocrine Tumor Society, and the North American Neuroendocrine Tumor Society were reviewed...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28873168/vision-screening-in-children-aged-6-months-to-5-years-us-preventive-services-task-force-recommendation-statement
#20
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: One of the most important causes of vision abnormalities in children is amblyopia (also known as "lazy eye"). Amblyopia is an alteration in the visual neural pathway in a child's developing brain that can lead to permanent vision loss in the affected eye. Among children younger than 6 years, 1% to 6% have amblyopia or its risk factors (strabismus, anisometropia, or both). Early identification of vision abnormalities could prevent the development of amblyopia. Subpopulation Considerations: Studies show that screening rates among children vary by race/ethnicity and family income...
September 5, 2017: JAMA: the Journal of the American Medical Association
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