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https://www.readbyqxmd.com/read/29331986/sex-differences-in-impact-of-coronary-artery-calcification-to-predict-coronary-artery-disease
#1
Yoko M Nakao, Yoshihiro Miyamoto, Masahiro Higashi, Teruo Noguchi, Mitsuru Ohishi, Isao Kubota, Hiroyuki Tsutsui, Tomohiro Kawasaki, Yutaka Furukawa, Michihiro Yoshimura, Hideaki Morita, Kunihiro Nishimura, Akiko Kada, Yoichi Goto, Tomonori Okamura, Chuwa Tei, Hitonobu Tomoike, Hiroaki Naito, Satoshi Yasuda
OBJECTIVE: To assess sex-specific differences regarding use of conventional risks and coronary artery calcification (CAC) to detect coronary artery disease (CAD) using coronary CT angiography (CCTA). METHODS: The Nationwide Gender-specific Atherosclerosis Determinants Estimation and Ischemic Cardiovascular Disease Prospective Cohort study is a prospective, multicentre, nationwide cohort study. Candidates with suspected CAD aged 50-74 years enrolled from 2008 to 2012...
January 13, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29329003/modified-forest-rotation-lengths-long-term-effects-on-landscape-scale-habitat-availability-for-specialized-species
#2
Jean-Michel Roberge, Karin Öhman, Tomas Lämås, Adam Felton, Thomas Ranius, Tomas Lundmark, Annika Nordin
We evaluated the long-term implications from modifying rotation lengths in production forests for four forest-reliant species with different habitat requirements. By combining simulations of forest development with habitat models, and accounting both for stand and landscape scale influences, we projected habitat availability over 150 years in a large Swedish landscape, using rotation lengths which are longer (+22% and +50%) and shorter (-22%) compared to current practices. In terms of mean habitat availability through time, species requiring older forest were affected positively by extended rotations, and negatively by shortened rotations...
January 9, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29328932/effective-algal-harvesting-by-using-mesh-membrane-for-enhanced-energy-recovery-in-an-innovative-integrated-photobioelectrochemical-system
#3
Shuai Luo, Pranav Sai Shankar Sampara, Zhen He
In this work, an innovative design of integrated photobioelectrochemcial system (IPB) and an algal harvesting method based on polyester-mesh membrane (MM) were investigated. The algal growth/harvesting period of 6 days led to the highest surface biomass productivity (SBP) of 0.88 g m-2 day-1 and the highest energy generation of 0.157 ± 0.001 kJ day-1. The harvesting frequency of 3 times in an operational cycle (with three pieces of MM) enhanced the SBP to 1.14 g m-2 day-1. The catholyte recirculation for catholyte mixing resulted in a positive net energy production (NEP) of 0...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29326152/decision-analytic-markov-model-weighting-expected-benefits-and-current-limitations-of-first-generation-bioresorbable-vascular-scaffolds-implications-for-manufacturers-and-next-device-iterations
#4
Davide Capodanno, Sergio Buccheri, Sara Romano, Piera Capranzano, Bruno Francaviglia, Corrado Tamburino
BACKGROUND: Relative benefits of bioresorbable vascular scaffolds (BVS) compared with everolimus-eluting stents (EES) are expected to accrue after complete bioresorption. METHODS AND RESULTS: We built a decision analytic Markov model comparing BVS and EES for a contemporary percutaneous coronary intervention population. Procedure-related morbidity and outcome data from the available literature were used to derive model probabilities. The net benefit of BVS and EES was estimated in terms of quality-adjusted life expectancy...
January 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29321554/mutations-in-dnmt3a-u2af1-and-ezh2-identify-intermediate-risk-acute-myeloid-leukemia-patients-with-poor-outcome-after-cr1
#5
Caner Saygin, Cassandra Hirsch, Bartlomiej Przychodzen, Mikkael A Sekeres, Betty K Hamilton, Matt Kalaycio, Hetty E Carraway, Aaron T Gerds, Sudipto Mukherjee, Aziz Nazha, Ronald Sobecks, Christopher Goebel, Donna Abounader, Jaroslaw P Maciejewski, Anjali S Advani
Intermediate-risk acute myeloid leukemia (IR-AML) is a clinically heterogeneous disease, for which optimal post-remission therapy is debated. The utility of next-generation sequencing information in decision making for IR-AML has yet to be elucidated. We retrospectively studied 100 IR-AML patients, defined by European Leukemia Net classification, who had mutational information at diagnosis, received intensive chemotherapy and achieved complete remission (CR) at Cleveland Clinic (CC). The Cancer Genome Atlas (TCGA) data were used for validation...
January 10, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29319249/stroke-prevention-in-atrial-fibrillation-which-is-the-best-balanced-in-efficacy-and-safety-as-a-thromboprophylactic
#6
Viraj Suvarna
Stroke prevention in atrial fibrillation (AF) has reached an exciting phase with a plethora of newer, potentially more efficacious and safer agents being introduced for physicians to select from. Dabigatran belongs to a class of anticoagulants called direct thrombin inhibitors, while rivaroxaban, apixaban, and edoxaban are direct Factor Xa inhibitors. Purely from a therapeutic endpoint perspective-based on the action of anticoagulants in reducing cardioembolic stroke-in clinical trials, one should look at whether a new anticoagulant in patients with AF prevents ischemic stroke...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29316935/estimating-the-returns-to-united-kingdom-publicly-funded-musculoskeletal-disease-research-in-terms-of-net-value-of-improved-health-outcomes
#7
Matthew Glover, Erin Montague, Alexandra Pollitt, Susan Guthrie, Stephen Hanney, Martin Buxton, Jonathan Grant
BACKGROUND: Building on an approach applied to cardiovascular and cancer research, we estimated the economic returns from United Kingdom public- and charitable-funded musculoskeletal disease (MSD) research that arise from the net value of the improved health outcomes in the United Kingdom. METHODS: To calculate the economic returns from MSD-related research in the United Kingdom, we estimated (1) the public and charitable expenditure on MSD-related research in the United Kingdom between 1970 and 2013; (2) the net monetary benefit (NMB), derived from the health benefit in quality adjusted life years (QALYs) valued in monetary terms (using a base-case value of a QALY of £25,000) minus the cost of delivering that benefit, for a prioritised list of interventions from 1994 to 2013; (3) the proportion of NMB attributable to United Kingdom research; and (4) the elapsed time between research funding and health gain...
January 10, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29316514/risk-based-cost-benefit-analysis-for-evaluating-microbial-risk-mitigation-in-a-drinking-water-system
#8
Viktor Bergion, Andreas Lindhe, Ekaterina Sokolova, Lars Rosén
Waterborne outbreaks of gastrointestinal diseases can cause large costs to society. Risk management needs to be holistic and transparent in order to reduce these risks in an effective manner. Microbial risk mitigation measures in a drinking water system were investigated using a novel approach combining probabilistic risk assessment and cost-benefit analysis. Lake Vomb in Sweden was used to exemplify and illustrate the risk-based decision model. Four mitigation alternatives were compared, where the first three alternatives, A1-A3, represented connecting 25, 50 and 75%, respectively, of on-site wastewater treatment systems in the catchment to the municipal wastewater treatment plant...
December 27, 2017: Water Research
https://www.readbyqxmd.com/read/29315513/climate-sensitivity-functions-and-net-primary-production-a-framework-for-incorporating-climate-mean-and-variability
#9
Jennifer A Rudgers, Y Anny Chung, Gregory E Maurer, Douglas I Moore, Esteban H Muldavin, Marcy E Litvak, Scott L Collins
Understanding controls on net primary production (NPP) has been a long-standing goal in ecology. Climate is a well-known control on NPP, although the temporal differences among years within a site are often weaker than the spatial pattern of differences across sites. Climate sensitivity functions describe the relationship between an ecological response (e.g., NPP) and both the mean and variance of its climate driver (e.g., aridity index), providing a novel framework for understanding how climate trends in both mean and variance vary with NPP over time...
January 9, 2018: Ecology
https://www.readbyqxmd.com/read/29315506/optimization-of-voriconazole-therapy-for-the-treatment-of-invasive-fungal-infections-in-adults
#10
Naveen Mangal, Issam Hamadeh, Meghan J Arwood, Larisa H Cavallari, Tanay S Samant, Kenneth P Klinker, Jurgen Bulitta, Stephan Schmidt
Therapeutic concentrations of voriconazole in invasive fungal infections (IFIs) are ensured using drug monitoring approach, which relies on attainment of steady state pharmacokinetics. For voriconazole, time to reach steady state can vary from 5-7 days, not optimal for critically ill patients. We developed a population pharmacokinetic/pharmacodynamic model-based approach to predict doses which can maximize the net benefit (probability of efficacy - probability of adverse events) and ensure therapeutic concentrations, early on during treatment...
January 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29315327/ambivalence-in-pregnancy-intentions-the-effect-of-quality-of-care-and-context-among-a-cohort-of-women-attending-family-planning-clinics-in-kenya
#11
Eliud Wekesa, Ian Askew, Timothy Abuya
CONTEXT: Ambivalence in pregnancy intentions is well-documented in sub-Saharan African (SSA) settings and has been associated with inconsistent use of contraception, thereby exposing women using contraception to the possibility of unintended pregnancies. A better understanding of the potential role for client counseling interventions in enabling women to achieve their pregnancy intentions is essential for aiding program efforts to reduce unintended pregnancies. OBJECTIVE: To measure ambivalence in pregnancy intentions longitudinally and determine its association with the quality of care received, controlling for demographic, socio-economic and contextual factors among a cohort of family planning (FP) clients in Kenya...
2018: PloS One
https://www.readbyqxmd.com/read/29315323/developing-a-theoretical-model-and-questionnaire-survey-instrument-to-measure-the-success-of-electronic-health-records-in-residential-aged-care
#12
Ping Yu, Siyu Qian
Electronic health records (EHR) are introduced into healthcare organizations worldwide to improve patient safety, healthcare quality and efficiency. A rigorous evaluation of this technology is important to reduce potential negative effects on patient and staff, to provide decision makers with accurate information for system improvement and to ensure return on investment. Therefore, this study develops a theoretical model and questionnaire survey instrument to assess the success of organizational EHR in routine use from the viewpoint of nursing staff in residential aged care homes...
2018: PloS One
https://www.readbyqxmd.com/read/29315116/minimally-invasive-spine-surgery-analyzing-internet-based-education-material
#13
Jessica Bryant, Rohith Mohan, Brian Koottappillil, Kevin Wong, Paul H Yi
STUDY DESIGN: This is a cross-sectional study. OBJECTIVE: The purpose of this study is to evaluate the content of information available on the Internet regarding minimally invasive spine surgery (MISS). SUMMARY OF BACKGROUND DATA: Patients look to the Internet for quick and accessible information on orthopedic procedures to help guide their personal decision making process regarding the care they receive. However, the quality of internet-based orthopedic education material varies significantly with respect to accuracy and readability...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29307102/sustainability-evaluation-of-mornos-lake-reservoir-greece
#14
Grigoris Rousakis, Ioannis P Panagiotopoulos, Paraskevi Drakopoulou, Panos Georgiou, Dimitrios Nikolopoulos, Nikolaos Mporompokas, Vasilios Kapsimalis, Isidoros Livanos, Ioannis A Morfis, Christos Anagnostou, Maria Koutra
The modern climate trend and population growth have dramatically increased the need for maximization of the net benefit from the existing storage space in freshwater reservoirs. However, sedimentation in reservoirs through physical deposition and/or slope failures is a major threat to their productivity and life expectancy. In this context, the sedimentation impact on the sustainability of Mornos Lake/Reservoir, which is exceptionally vital for the ~ 3.1 million inhabitants of Athens, had to be evaluated...
January 6, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29304938/payer-and-pharmaceutical-manufacturer-considerations-for-outcomes-based-agreements-in-the-united-states
#15
Joshua D Brown, Rich Sheer, Margaret Pasquale, Lavanya Sudharshan, Kirsten Axelsen, Prasun Subedi, Daniel Wiederkehr, Fred Brownfield, Sachin Kamal-Bahl
BACKGROUND: Considerable interest exists among health care payers and pharmaceutical manufacturers in designing outcomes-based agreements (OBAs) for medications for which evidence on real-world effectiveness is limited at product launch. OBJECTIVES: To build hypothetical OBA models in which both payer and manufacturer can benefit. METHODS: Models were developed for a hypothetical hypercholesterolemia OBA, in which the OBA was assumed to increase market access for a newly marketed medication...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29304936/cost-effectiveness-and-value-of-information-analysis-of-brief-interventions-to-promote-physical-activity-in-primary-care
#16
Vijay Singh Gc, Marc Suhrcke, Wendy Hardeman, Stephen Sutton, Edward C F Wilson
BACKGROUND: Brief interventions (BIs) delivered in primary care have shown potential to increase physical activity levels and may be cost-effective, at least in the short-term, when compared with usual care. Nevertheless, there is limited evidence on their longer term costs and health benefits. OBJECTIVES: To estimate the cost-effectiveness of BIs to promote physical activity in primary care and to guide future research priorities using value of information analysis...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29301646/impact-of-sex-on-comparative-outcomes-of-radial-versus-femoral-access-in-patients-with-acute-coronary-syndromes-undergoing-invasive-management-data-from-the-randomized-matrix-access-trial
#17
Giuseppe Gargiulo, Sara Ariotti, Pascal Vranckx, Sergio Leonardi, Enrico Frigoli, Nestor Ciociano, Carlo Tumscitz, Francesco Tomassini, Paolo Calabrò, Stefano Garducci, Gabriele Crimi, Giuseppe Andò, Maurizio Ferrario, Ugo Limbruno, Bernardo Cortese, Paolo Sganzerla, Alessandro Lupi, Filippo Russo, Roberto Garbo, Arturo Ausiello, Dennis Zavalloni, Gennaro Sardella, Giovanni Esposito, Andrea Santarelli, Simone Tresoldi, Marco Stefano Nazzaro, Antonio Zingarelli, Anna Sonia Petronio, Stephan Windecker, Bruno R da Costa, Marco Valgimigli
OBJECTIVES: This study sought to assess whether transradial access (TRA) compared with transfemoral access (TFA) is associated with consistent outcomes in male and female patients with acute coronary syndrome undergoing invasive management. BACKGROUND: There are limited and contrasting data about sex disparities for the safety and efficacy of TRA versus TFA for coronary intervention. METHODS: In the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) program, 8,404 patients were randomized to TRA or TFA...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29298322/economic-evaluation-of-interventions-designed-to-reduce-clostridium-difficile-infection
#18
David Brain, Laith Yakob, Adrian Barnett, Thomas Riley, Archie Clements, Kate Halton, Nicholas Graves
INTRODUCTION: Healthcare decision-makers are increasingly expected to balance increasing demand for health services with a finite budget. The role of economic evaluation in healthcare is increasing and this research provides decision-makers with new information about the management of Clostridium difficile infection, from an economic perspective. METHODS: A model-based economic evaluation was undertaken to identify the most cost-effective healthcare intervention relating to the reduction of Clostridium difficile transmission...
2018: PloS One
https://www.readbyqxmd.com/read/29291417/performance-of-qsofa-and-sofa-for-predicting-mortality-in-patients-with-acute-pyelonephritis-associated-with-upper-urinary-tract-calculi
#19
Hiroshi Fukushima, Masaki Kobayashi, Keizo Kawano, Shinji Morimoto
PURPOSE: The Sepsis-3 Task Force proposed a new definition of sepsis based on SOFA and introduced a novel scoring system, qSOFA, for screening high-risk patients for sepsis. Their clinical usefulness, however, is unclear. Therefore, we investigated their predictive performance for mortality in APN-UTC patients. MATERIALS AND METHODS: This retrospective study included 141 consecutive patients clinically diagnosed with APN-UTC outside the ICU. We evaluated the performance of qSOFA, SOFA, and SIRS in predicting in-hospital mortality and ICU admission using the AUC of the ROC curve, NRI, IDI, and decision curve analysis...
December 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29290966/development-of-a-nomogram-for-screening-of-hepatitis-b-virus-associated-hepatocellular-carcinoma
#20
Jung Wha Chung, Eun Sun Jang, Jaihwan Kim, Sook-Hyang Jeong, Nayoung Kim, Dong Ho Lee, Kyung Ho Lee, Jin-Wook Kim
Current strategy of hepatocellular carcinoma (HCC) surveillance evaluates individual risks of HCC for defining candidates for surveillance, but estimated risks are not utilized for clinical decision-making during actual screening. We sought to determine whether consideration of individual risks improve the performance of ultrasound (US)-based HCC screening in a real-world chronic hepatitis B (CHB) cohort. This single center retrospective cohort study analyzed 27,722 screening US tests from 4,175 consecutive CHB patients...
December 5, 2017: Oncotarget
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