keyword
MENU ▼
Read by QxMD icon Read
search

Net benefit

keyword
https://www.readbyqxmd.com/read/28806775/depression-screening-with-patient-targeted-feedback-in-cardiology-the-cost-effectiveness-of-depscreen-info
#1
Christian Brettschneider, Sebastian Kohlmann, Benjamin Gierk, Bernd Löwe, Hans-Helmut König
BACKGROUND: Although depression is common in patients with heart disease, screening for depression is much debated. DEPSCREEN-INFO showed that a patient-targeted feedback in addition to screening results in lower depression level six months after screening. The purpose of this analysis was to perform a cost-effectiveness analysis of DEPSCREEN-INFO. METHODS: Patients with coronary heart disease or arterial hypertension were included. Participants in both groups were screened for depression...
2017: PloS One
https://www.readbyqxmd.com/read/28801424/a-cost-effectiveness-comparison-of-the-nice-2015-and-who-2013-diagnostic-criteria-for-women-with-gestational-diabetes-with-and-without-risk-factors
#2
Paul Brian Jacklin, Michael Ja Maresh, Chris C Patterson, Katharine P Stanley, Anne Dornhorst, Shona Burman-Roy, Rudy W Bilous
OBJECTIVES: To compare the cost-effectiveness (CE) of the National Institute for Health and Care Excellence (NICE) 2015 and the WHO 2013 diagnostic thresholds for gestational diabetes mellitus (GDM). SETTING: The analysis was from the perspective of the National Health Service in England and Wales. PARTICIPANTS: 6221 patients from four of the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study centres (two UK, two Australian), 6308 patients from the Atlantic Diabetes in Pregnancy study and 12 755 patients from UK clinical practice...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801396/the-sims-trial-adjustable-anchored-single-incision-mini-slings-versus-standard-tension-free-midurethral-slings-in-the-surgical-management-of-female-stress-urinary-incontinence-a-study-protocol-for-a-pragmatic-multicentre-non-inferiority-randomised-controlled
#3
Mohamed Abdel-Fattah, Graeme MacLennan, Mary Kilonzo, R Phil Assassa, Kirsty McCormick, Tracey Davidson, Alison McDonald, James N'Dow, Judith Wardle, John Norrie
INTRODUCTION: Single-incision mini-slings (SIMS) represent the third generation of midurethral slings. They have been developed with the aim of offering a true ambulatory procedure for treatment of female stress urinary incontinence (SUI) with reduced morbidity and earlier recovery while maintaining similar efficacy to standard midurethral slings (SMUS). The aim of this study is to determine the clinical and cost-effectiveness of adjustable anchored SIMS compared with tension-free SMUS in the surgical management of female SUI, with 3-year follow-up...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799620/long-term-bleeding-risk-prediction-in-real-world-patients-with-atrial-fibrillation-comparison-of-the-has-bled-and-abc-bleeding-risk-scores-the-murcia-atrial-fibrillation-project
#4
María Asunción Esteve-Pastor, José Miguel Rivera-Caravaca, Vanessa Roldan, Vicente Vicente, Mariano Valdés, Francisco Marín, Gregory Y H Lip
Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better than HAS-BLED score in a clinical trial cohort but has not been externally validated. It was the aim of this study to compare the predictive performance of the ABC-Bleeding score compared to HAS-BLED score in an independent "real-world" anticoagulated AF patients with long-term follow-up...
August 11, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28799460/economic-and-social-impact-of-increased-cardiac-rehabilitation-uptake-and-cardiac-telerehabilitation-in-belgium-a-cost-benefit-analysis
#5
Ines Frederix, Dominique Vandijck, Niel Hens, Johan De Sutter, Paul Dendale
BACKGROUND: Cardiac rehabilitation for ischaemic heart disease effectively reduces cardiovascular readmission rate and mortality. Current uptake rates however, remain low. This study assesses the social and economic impact of increasing centre-based cardiac rehabilitation uptake and the additional value of cardiac telerehabilitation using cost-benefit analysis (CBA) in Belgium. METHODS: Cost-benefit analysis was conducted to analyse three scenarios: (1) current situation: 20% uptake rate of cardiac rehabilitation; (2) alternative scenario one: 40% uptake rate of cardiac rehabilitation; and (3) alternative scenario two: 20% uptake of cardiac rehabilitation and 20% uptake of both cardiac rehabilitation and telerehabilitation...
August 11, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28798292/14-5%C3%A2-ghz-passive-harmonic-mode-locking-in-a-dispersion-compensated-tm-doped-fiber-laser
#6
Yazhou Wang, Jianfeng Li, Kundong Mo, Yanyan Wang, Fei Liu, Yong Liu
We demonstrate a high repetition rate passive harmonic mode-locking (HML) based on nonlinear polarization evolution (NPE) technique in a Tm-doped ring fiber laser cavity. Small net anomalous cavity dispersion based on dispersion compensation benefited the generation of high repetition rate HML due to the low soliton splitting threshold. Stable HML with a repetition rate of up to 14.5 GHz and a super-mode suppression (SSR) of 19 dB was obtained at the center wavelength of 1982.3 nm, which is about ten times of state of the art at 2 μm band mode-locking fiber laser to our best knowledge...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797421/net-health-benefit-positive-for-cac-scanning
#7
EDITORIAL
Leslee J Shaw, Jagat Narula, Y Chandrashekhar
No abstract text is available yet for this article.
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28791798/cost-effectiveness-analysis-of-potentially-curative-and-combination-treatments-for-hepatocellular-carcinoma-with-person-level-data-in-a-canadian-setting
#8
Hla-Hla Thein, Wanrudee Isaranuwatchai, Yao Qiao, Kenny Wong, Gonzalo Sapisochin, Kelvin K W Chan, Eric M Yoshida, Craig C Earle
Patients with early-stage hepatocellular carcinoma (HCC) are potential candidates for curative treatments such as radiofrequency ablation (RFA), surgical resection (SR), or liver transplantation (LT), which have demonstrated a significant survival benefit. We aimed to estimate the cost-effectiveness of curative and combination treatment strategies among patients diagnosed with HCC during 2002-2010. This study used Ontario Cancer Registry-linked administrative data to estimate effectiveness and costs (2013 USD) of the treatment strategies from the healthcare payer's perspective...
August 8, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28789811/strategic-considerations-for-the-sustainable-remediation-of-nuclear-installations
#9
S Mobbs, P Orr, I Weber
Nuclear sites around the world are being decommissioned and remedial actions are being undertaken to enable the sites or parts of the sites to be reused. Although this is relatively straightforward for most sites, experience has suggested that preventative action is needed to minimise the impact of remediation activities on the environment and the potential burden to future generations. Removing all contamination in order to make a site suitable for any use generates waste and has associated environmental, social and economic detriments and benefits that should be taken into account...
August 5, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28781157/comparative-environmental-evaluation-of-construction-waste-management-through-different-waste-sorting-systems-in-hong-kong
#10
Md Uzzal Hossain, Zezhou Wu, Chi Sun Poon
This study aimed to compare the environmental performance of building construction waste management (CWM) systems in Hong Kong. Life cycle assessment (LCA) approach was applied to evaluate the performance of CWM systems holistically based on primary data collected from two real building construction sites and secondary data obtained from the literature. Different waste recovery rates were applied based on compositions and material flow to assess the influence on the environmental performance of CWM systems...
August 3, 2017: Waste Management
https://www.readbyqxmd.com/read/28777651/safety-net-academic-hospital-experience-in-following-up-noncritical-yet-potentially-significant-radiologist-recommendations
#11
Nadja Kadom, Gemma Doherty, Alexandra Solomon, Madison Close, Scott Friedman, Deborah Gregson, Bradley S Rostad, James M Moses, Alexander Norbash
OBJECTIVE: In this retrospective study, we identified the types of noncritical recommendations radiologists issued over a 15-day period, the percentage of noncritical radiology recommendations that were not acted on or acknowledged in the medical records, potential causes for recommendations not being acted on, and the potential risk of harm to patients. MATERIALS AND METHODS: We conducted a retrospective review of radiology reports and patient records from January 1, 2014, to January 15, 2014, at a large tertiary academic center and regional safety-net hospital...
August 4, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28774856/modafinil-improves-attentional-performance-in-healthy-non-sleep-deprived-humans-at-doses-not-inducing-hyperarousal-across-species
#12
Zackary A Cope, Arpi Minassian, Dustin Kreitner, David A MacQueen, Morgane Milienne-Petiot, Mark A Geyer, William Perry, Jared W Young
The wake-promoting drug modafinil is frequently used off-label to improve cognition in psychiatric and academic populations alike. The domain-specific attentional benefits of modafinil have yet to be quantified objectively in healthy human volunteers using tasks validated for comparison across species. Further, given that modafinil is a low-affinity inhibitor for the dopamine and norepinephrine transporters (DAT/NET respectively) it is unclear if any effects are attributable to a non-specific increase in arousal, a feature of many catecholamine reuptake inhibitors (e...
August 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28772094/pharmacovigilance-in-hospice-palliative-care-net-effect-of-haloperidol-for-nausea-or-vomiting
#13
Madeline Digges, Akram Hussein, Andrew Wilcock, Gregory B Crawford, Jason W Boland, Meera R Agar, Aynharan Sinnarajah, David C Currow, Miriam J Johnson
BACKGROUND: Haloperidol is widely prescribed as an antiemetic in patients receiving palliative care, but there is limited evidence to support and refine its use. OBJECTIVE: To explore the immediate and short-term net clinical effects of haloperidol when treating nausea and/or vomiting in palliative care patients. DESIGN: A prospective, multicenter, consecutive case series. SETTING/SUBJECTS: Twenty-two sites, five countries: consultative, ambulatory, and inpatient services...
August 3, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28765860/assessing-the-efficacy-of-cancer-screening
#14
Gemma Jacklyn, Katy Bell, Andrew Hayen
BACKGROUND: Population-based cancer screening has been established for several types of cancer in Australia and internationally. Screening may perform differently in practice from randomised controlled trials, which makes evaluating programs complex. MATERIALS AND METHODS: We discuss how to assess the evidence of benefits and harms of cancer screening, including the main biases that can mislead clinicians and policy makers (such as volunteer, lead-time, length-time and overdiagnosis bias)...
July 26, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28764890/the-impact-of-a-retail-prescription-synchronization-program-on-medication-adherence
#15
Charmaine Girdish, William Shrank, Sarah Freytag, David Chen, Doug Gebhard, Andrew Bunton, Niteesh Choudhry, Jennifer Polinski
OBJECTIVES: To understand the impact of prescription synchronization, offered through the ScriptSync® program at CVS pharmacies nationwide, on adherence and reducing visits to the pharmacy. DESIGN: Cohort study, conducted between March 26, 2015, and December 18, 2015. Program enrollment occurred in August 2015, with a 120-day baseline period preceding enrollment and a 120-day follow-up period. SETTING AND PARTICIPANTS: CVS retail community pharmacies across the United States...
July 29, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28762617/effect-of-extended-duration-thromboprophylaxis-on-venous-thromboembolism-and-major-bleeding-among-acutely-ill-hospitalized-medical-patients-a-bivariate-analysis
#16
Gerald Chi, Samuel Z Goldhaber, John M Kittelson, Alexander G G Turpie, Adrian F Hernandez, Russell D Hull, Alex Gold, John T Curnutte, Alexander T Cohen, Robert A Harrington, C Michael Gibson
BACKGROUND: Among acutely ill hospitalized medical patients, extended-duration thromboprophylaxis reduces venous thromboembolism (VTE), but some pharmacologic strategies have been associated with greater risks of major bleeding, thereby offsetting the net clinical benefit (NCB). METHODS: To assess the risk-benefit profile of anticoagulation regimens, a previously described bivariate method that does not assume a linear risk-benefit tradeoff and can accommodate different margins for efficacy and safety was performed to simultaneously assess efficacy (symptomatic VTE) and safety (major bleeding) based on data from four randomized controlled trials of extended-duration (30 to 46 days) versus standard-duration (6 to 14 days) thromboprophylaxis among 28,227 patients (EXCLAIM, ADOPT, MAGELLAN, and APEX trials)...
August 1, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28761758/the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale-field-tested-in-infrequent-tumour-entities-an-extended-analysis-of-its-feasibility-at-the-medical-university-of-vienna
#17
Barbara Kiesewetter, Markus Raderer, Gerald W Prager, Thorsten Fuereder, Christine Marosi, Matthias Preusser, Michael Krainer, Gottfried J Locker, Thomas Brodowicz, Christoph C Zielinski
BACKGROUND: The European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a new tool to quantify the clinical benefit that may be anticipated from a novel anticancer treatment. We present here an analysis on the feasibility of the ESMO-MCBS in less frequent tumour entities. METHODS: This study evaluates the practicability of the ESMO-MCBS for metastatic neuroendocrine tumours (NETs), soft tissue sarcomas, glioblastoma, thyroid cancer, pancreatic cancer, head/neck cancer, urothelial cancer and ovarian cancer at the Medical University Vienna...
2017: ESMO Open
https://www.readbyqxmd.com/read/28754465/evaluation-of-pharmacokinetic-and-pharmacodynamic-profiles-of-liposomes-for-the-cell-type-specific-delivery-of-small-molecule-drugs
#18
Siva Sai Krishna Dasa, Ryo Suzuki, Emily Mugler, Lanlin Chen, Rasmus Jansson-Löfmark, Erik Michaëlsson, Lennart Lindfors, Alexander L Klibanov, Brent A French, Kimberly A Kelly
Liposome-based drug formulations represent an exciting avenue of research as they increase efficacy to toxicity ratios. Current formulations rely on passive accumulation to the disease site where drug is taken up by the cells. Ligand mediated targeting increases the net accumulation of liposomes, however, an unexplored benefit is to potentially refine pharmacodynamics (PD) of a drug specifically to different cell types within diseased tissue. As a model system, we engineered cardiomyocyte- (I-1) and endothelial-targeted (B-40) liposomes to carry a VEGFR2 inhibitor (PTK787), and examined the effect of cell type-specific delivery on both pharmacokinetics (PK) and PD...
July 25, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28753781/prediction-of-prostate-cancer-external-validation-of-the-erspc-risk-calculator-in-a-contemporary-dutch-clinical-cohort
#19
Maudy Gayet, Christophe K Mannaerts, Daan Nieboer, Harrie P Beerlage, Hessel Wijkstra, Peter F A Mulders, Monique J Roobol
BACKGROUND: The validity of prediction models needs external validation to assess their value beyond the original development setting. OBJECTIVE: To report the diagnostic accuracy of the European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator (RC)3 and RC4 in a contemporary Dutch clinical cohort. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively identified all men who underwent prostate biopsy (PBx) in the Jeroen Bosch Hospital, The Netherlands, between 2007 and 2016...
August 4, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28749984/foregone-benefits-of-important-food-crop-improvements-in-sub-saharan-africa
#20
Justus Wesseler, Richard D Smart, Jennifer Thomson, David Zilberman
A number of new crops have been developed that address important traits of particular relevance for smallholder farmers in Africa. Scientists, policy makers, and other stakeholders have raised concerns that the approval process for these new crops causes delays that are often scientifically unjustified. This article develops a real option model for the optimal regulation of a risky technology that enhances economic welfare and reduces malnutrition. We consider gradual adoption of the technology and show that delaying approval reduces uncertainty about perceived risks of the technology...
2017: PloS One
keyword
keyword
64767
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"