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Subjective cognitive impairment

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https://www.readbyqxmd.com/read/28096845/cognitive-impairment-after-sudden-cardiac-arrest
#1
Magdalena Jaszke-Psonka, Magdalena Piegza, Piotr Ścisło, Robert Pudlo, Jacek Piegza, Karina Badura-Brzoza, Aleksandra Leksowska, Robert T Hese, Piotr W Gorczyca
AIM: To evaluate the incidence and severity of the impairment of selected cognitive functions in patients after sudden cardiac arrest (SCA) in comparison to patients after myocardial infarction without SCA and healthy subjects and to analyze the influence of sociodemographic and clinical parameters and the duration of cardiac arrest on the presence and severity of the described disorders. MATERIAL AND METHODS: The study group comprised 30 cardiac arrest survivors, the reference group comprised 31 survivors of myocardial infarction without cardiac arrest, and the control group comprised 30 healthy subjects...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28096673/apathy-and-intrinsic-functional-connectivity-networks-in-amnestic-mild-cognitive-impairment
#2
Soo Hyun Joo, Chang Uk Lee, Hyun Kook Lim
BACKGROUND: Although several prior works reported that apathy is associated with conversion to Alzheimer's disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects. METHODS: Fifty subjects with aMCI and 50 controls (CONs) participated in this study...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28094171/the-relationship-of-cognitive-improvement-after-cognitive-remediation-with-social-functioning-in-patients-with-schizophrenia-and-severe-cognitive-deficits
#3
J P Lindenmayer, Samantha Fregenti, Guoxin Kang, Veronica Ozog, Isidora Ljuri, Anzalee Khan, A Goldring, Susan R McGurk
BACKGROUND: This study aims to examine the effects of change in neurocognition on functional outcomes and to examine predictors of change in social functions following a 12-week course of cognitive remediation in patients with schizophrenia and schizoaffective disorder with severe cognitive impairments. METHOD: Level of social functioning was assessed using a performance based measure of functional capacity (PSP) in patients prior to and after the completion of 12-week cognitive remediation treatment (CRT)...
January 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28092591/relational-regularized-discriminative-sparse-learning-for-alzheimer-s-disease-diagnosis
#4
Baiying Lei, Peng Yang, Tianfu Wang, Siping Chen, Dong Ni
Accurate identification and understanding informative feature is important for early Alzheimer's disease (AD) prognosis and diagnosis. In this paper, we propose a novel discriminative sparse learning method with relational regularization to jointly predict the clinical score and classify AD disease stages using multimodal features. Specifically, we apply a discriminative learning technique to expand the class-specific difference and include geometric information for effective feature selection. In addition, two kind of relational information are incorporated to explore the intrinsic relationships among features and training subjects in terms of similarity learning...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28091977/a-cross-sectional-snapshot-of-sleep-quality-and-quantity-among-us-medical-students
#5
Erin E Ayala, Rani Berry, Jeffrey S Winseman, Hyacinth Rc Mason
OBJECTIVE: Fatigue is a well-known risk factor for mood disturbances, decreased cognitive acuity, and impaired judgment. Sleep research in medical students typically focuses on sleep quantity, but less is known about the quality of a student's sleep. The purpose of this investigation was to examine the subjective sleep quality and quantity of US medical students and to identify differences in sleep characteristics across demographic groups. METHODS: Medical students (N = 860) representing 49 medical colleges completed the Medical Outcomes Study Sleep Scale and a demographic questionnaire between December 2015 and March 2016...
January 13, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28091829/inhibition-of-dpp-4-activity-and-neuronal-atrophy-with-genistein-attenuates-neurological-deficits-induced-by-transient-global-cerebral-ischemia-and-reperfusion-in-streptozotocin-induced-diabetic-mice
#6
Mithun Singh Rajput, Purnima Dey Sarkar, Nilesh Prakash Nirmal
Genistein, an isoflavonoid phytoestrogen, has been known for its potential pharmacological properties especially for neuroprotection and treating diabetes. The present study aims to determine the neuroprotective efficacy of genistein against global cerebral ischemia-reperfusion-induced neuronal injury in streptozotocin-induced diabetic mice and explore the underlying mechanisms. Streptozotocin-induced diabetic mice were subjected to transient cerebral ischemia by occluding both common carotid arteries for 30 min followed by 24 h reperfusion to induce neuronal injury...
January 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28089970/spatial-working-memory-impairment-in-patients-with-non-neuropsychiatric-systemic-lupus-erythematosus-a-blood-oxygen-level-dependent-functional-magnetic-resonance-imaging-study
#7
Chun-Min Zhu, Ye Ma, Lei Xie, Jin-Zhuang Huang, Zong-Bo Sun, Shou-Xing Duan, Zhi-Rong Lin, Jing-Jing Yin, Hong-Bo Le, Dan-Miao Sun, Wen-Can Xu, Shu-Hua Ma
OBJECTIVE: Using ethology and functional magnetic resonance imaging (fMRI) to explore mild cognitive dysfunction and spatial working memory (WM) impairment in patients with systemic lupus erythematosus (SLE) without overt neuropsychiatric symptoms (non-NPSLE) and to study whether any clinical biomarkers could serve as predictors of brain dysfunction in this disease. METHODS: Eighteen non-NPSLE patients and 18 matched subjects were all tested using the Montreal cognitive assessment scale test and scanned using blood-oxygen-level dependent fMRI while performing the n-back task to investigate the activation intensity of some cognition-related areas...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089560/critical-role-of-p2x7-receptors-in-the-neuroinflammation-and-cognitive-dysfunction-after-surgery
#8
Bin Zheng, Renchun Lai, Jun Li, Zhiyi Zuo
Postoperative cognitive dysfunction worsens patient outcome after surgery. Neuroinflammation is a critical neuropathological process for it. We determined the role of P2X7 receptors, proteins that participate in inflammatory response, in the neuroinflammation induction after surgery, and whether the choice of volatile anesthetics affects its occurrence. Eight-week old C57BL/6J or P2X7 receptor knockout male mice were subjected to right carotid arterial exposure under anesthesia with 1.8% isoflurane, 2.5% sevoflurane or 10% desflurane...
January 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28089226/-coping-and-subjective-burden-in-primary-caregivers-of-dependent-elderly-relatives-in-andalusia-spain
#9
Margarita Pérez-Cruz, M Ángeles Muñoz-Martínez, Laura Parra-Anguita, Rafael Del-Pino-Casado
PURPOSE: To analyse the relationship between the type of coping and subjective burden in caregivers of dependent elderly relatives in Andalusia (Spain). DESIGN: Cross-sectional study. LOCATION: Primary Health Care (autonomous community of Andalusia, Spain). PARTICIPANTS: A convenience sample of 198 primary caregivers of dependent elderly relatives. KEY MEASUREMENTS: Coping (Brief COPE), subjective burden (caregiver stress index), objective burden (functional capacity [Barthel Index], cognitive impairment [Pfeiffer Test], behavioural problems of the care recipient [Neuropsychiatric Inventory], and caregivers' dedication to caring), gender and kinship...
January 11, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28088928/multi-modal-mri-investigation-of-volumetric-and-microstructural-changes-in-the-hippocampus-and-its-subfields-in-mild-cognitive-impairment-alzheimer-s-disease-and-dementia-with-lewy-bodies
#10
Elijah Mak, Silvy Gabel, Li Su, Guy B Williams, Robert Arnold, Luca Passamonti, Patricia Vazquez Rodríguez, Ajenthan Surendranathan, W Richard Bevan-Jones, James B Rowe, John T O'Brien
BACKGROUND: Volumetric atrophy and microstructural alterations in diffusion tensor imaging (DTI) measures of the hippocampus have been reported in people with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, no study to date has jointly investigated concomitant microstructural and volumetric changes of the hippocampus in dementia with Lewy bodies (DLB). METHODS: A total of 84 subjects (23 MCI, 17 DLB, 14 AD, and 30 healthy controls) were recruited for a multi-modal imaging (3T MRI and DTI) study that included neuropsychological evaluation...
January 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28088658/exposure-to-chronic-early-life-stress-lastingly-alters-the-adipose-tissue-the-leptin-system-and-changes-the-vulnerability-to-western-style-diet-later-in-life-in-mice
#11
K Y Yam, E F G Naninck, M R Abbink, S E la Fleur, L Schipper, J C van den Beukel, A Grefhorst, A Oosting, E M van der Beek, P J Lucassen, A Korosi
Early-life stress (ES) increases the vulnerability to develop psychopathologies and cognitive decline in adulthood. Interestingly, this is often comorbid with metabolic disorders, such as obesity. However, it is unclear whether ES leads to lasting metabolic changes and to what extent this is associated with the ES-induced cognitive impairments. Here, we used an established chronic ES mouse model (from postnatal day (P) 2 to P9) to investigate the short- and long-term effects of ES exposure on parameters of the adipose tissue and the leptin system (i...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28088604/alba-screening-instrument-asi-a-brief-screening-tool-for-lewy-body-dementia
#12
M M Garcia Basalo, M C Fernandez, M Ojea Quintana, J I Rojas, M J Garcia Basalo, E Bogliotti, N Campora, M Fernandez, W Berrios, E Cristiano, A Golimstok
BACKGROUND: Early detection of neurodegenerative diseases is essential for treatment and proper care of these patients. Screening tools available today are effective for several types of dementia. However, there is no one specific for Lewy Body Dementia (LBD). OBJECTIVES: The aim of this paper is to present a tool for early detection of LBD, accessible even for non-medical staff. METHODS: We stratified subjects (MMSE>20) into four groups: health controls (HC), Mild Cognitive Impairment (MCI), LBD and other dementias (Alzheimer and vascular)...
January 5, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28080965/feeling-learning-from-and-being-aware-of-inner-states-interoceptive-dimensions-in-neurodegeneration-and-stroke
#13
Indira García-Cordero, Lucas Sedeño, Laura de la Fuente, Andrea Slachevsky, Gonzalo Forno, Francisco Klein, Patricia Lillo, Jesica Ferrari, Clara Rodriguez, Julian Bustin, Teresa Torralva, Sandra Baez, Adrian Yoris, Sol Esteves, Margherita Melloni, Paula Salamone, David Huepe, Facundo Manes, Adolfo M García, Agustín Ibañez
Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout the vast interoceptive network. To this end, we obtained relevant measures of cardiac interoception in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal brain damage: behavioural variant fronto-temporal dementia (bvFTD), Alzheimer's disease (AD) and fronto-insular stroke...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28079104/longitudinal-measurement-and-hierarchical-classification-framework-for-the-prediction-of-alzheimer-s-disease
#14
Meiyan Huang, Wei Yang, Qianjin Feng, Wufan Chen
Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078566/an-eye-tracking-controlled-neuropsychological-battery-for-cognitive-assessment-in-neurological-diseases
#15
Barbara Poletti, Laura Carelli, Federica Solca, Annalisa Lafronza, Elisa Pedroli, Andrea Faini, Stefano Zago, Nicola Ticozzi, Andrea Ciammola, Claudia Morelli, Paolo Meriggi, Pietro Cipresso, Dorothée Lulé, Albert C Ludolph, Giuseppe Riva, Vincenzo Silani
Traditional cognitive assessment in neurological conditions involving physical disability is often prevented by the presence of verbal-motor impairment; to date, an extensive motor-verbal-free neuropsychological battery is not available for such purposes. We adapted a set of neuropsychological tests, assessing language, attentional abilities, executive functions and social cognition, for eye-tracking (ET) control, and explored its feasibility in a sample of healthy participants. Thirty healthy subjects performed a neuropsychological assessment, using an ET-based neuropsychological battery, together with standard "paper and pencil" cognitive measures for frontal (Frontal Assessment Battery-FAB) and working memory abilities (Digit Sequencing Task) and for global cognitive efficiency (Montreal Cognitive Assessment-MoCA)...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28077397/relationships-between-flortaucipir-pet-tau-binding-and-amyloid-burden-clinical-diagnosis-age-and-cognition
#16
Michael J Pontecorvo, Michael D Devous, Michael Navitsky, Ming Lu, Stephen Salloway, Frederick W Schaerf, Danna Jennings, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Abhinay D Joshi, Andrew Siderowf, Mark A Mintun
The advent of tau-targeted positron emission tomography tracers such as flortaucipir ((18)F-AV-1451, also known as (18)F-T807) have made it possible to investigate the sequence of development of tau and amyloid-β in relationship to age, and to the development of cognitive impairment due to Alzheimer's disease. In this study, flortaucipir tau and florbetapir amyloid positron emission tomography were obtained for 217 subjects including 16 young and 58 older cognitively normal subjects, 95 subjects with mild cognitive impairment (Mini-Mental State Examination 24-30) and 48 subjects with clinically-defined possible or probable Alzheimer's disease (Mini-Mental State Examination >10)...
January 11, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28077020/relationship-between-18-f-flutemetamol-uptake-and-rbans-performance-in-non-demented-community-dwelling-older-adults
#17
Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Britney E Beardmore, Lance D Burrell, Kevin P Horn, Kelli M Rasmussen, Norman L Foster, Kevin Duff, John M Hoffman
OBJECTIVE: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been used extensively for clinical care and in research for patients with mild cognitive impairment and Alzheimer's disease (AD); however, relatively few studies have evaluated the relationship between RBANS performance and AD imaging biomarkers. The purpose of the current study was to evaluate the association between a relatively new amyloid positron emission tomography imaging biomarker and performance on the RBANS...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28076308/measurements-of-serum-non-ceruloplasmin-copper-by-a-direct-fluorescent-method-specific-to-cu-ii
#18
Rosanna Squitti, Mariacristina Siotto, Emanuele Cassetta, Imane Ghafir El Idrissi, Nicola A Colabufo
BACKGROUND: Meta-analyses indicated the breakdown of copper homeostasis in the sporadic form of Alzheimer's disease (AD), comprising copper decreases within the brain and copper increases in the blood and the pool not bound to ceruloplasmin (non-Cp Cu, also known in the literature as "free" copper). The calculated non-Cp Cu (Walshe's) index has many limitations. METHODS: A direct fluorescent method for non-Cp Cu detection has been developed and data are presented herein...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28074926/disrupted-global-metastability-and-static-and-dynamic-brain-connectivity-across-individuals-in-the-alzheimer-s-disease-continuum
#19
Aldo Córdova-Palomera, Tobias Kaufmann, Karin Persson, Dag Alnæs, Nhat Trung Doan, Torgeir Moberget, Martina Jonette Lund, Maria Lage Barca, Andreas Engvig, Anne Brækhus, Knut Engedal, Ole A Andreassen, Geir Selbæk, Lars T Westlye
As findings on the neuropathological and behavioral components of Alzheimer's disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074347/pattern-and-motion-related-visual-evoked-potentials-in-hiv-infected-adults
#20
Jana Szanyi, Jan Kremlacek, Zuzana Kubova, Miroslav Kuba, Pavel Gebousky, Jaroslav Kapla, Juraj Szanyi, Frantisek Vit, Jana Langrova
PURPOSE: The goal of the current study was to explore visual function in virally suppressed HIV patients undergoing combined antiretroviral therapy (cART) by using pattern-reversal and motion-onset visual evoked potentials (VEPs). METHODS: The pattern-reversal and motion-onset VEPs were recorded in 20 adult HIV+ patients with a mean age of 38 years and CD4 cell counts ≥230 × 10(6) cells/L of blood. RESULTS: Nine out of 20 patients displayed VEP abnormalities...
January 10, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
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