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JOURNAL ARTICLE
Kevin Pacheco-Barrios, Paulo E P Teixeira, Daniela Martinez-Magallanes, Moacir Silva Neto, Elly Angelica Pichardo, Lucas Camargo, Daniel Lima, Alejandra Cardenas-Rojas, Felipe Fregni
BACKGROUND: The different clinical presentations of fibromyalgia (FMS) may play independent roles in the unclear etiology of cognitive impairments and depressive symptoms seen in this population. Understanding how these clinical presentations are associated with FMS's clinical and neurophysiological aspects is important when developing effective treatments. AIM: To explore the relationship between memory complaints and depressive symptoms, and the different clinical and neurophysiological characteristics of FMS...
April 23, 2024: Pain Medicine
#2
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#3
JOURNAL ARTICLE
Melmar Folloso, Steven Villaraza, Yi-Wen Lo, Pek-Lan Khong, Tomotaka Tanaka, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen
BACKGROUND: There are major challenges in determining the aetiology of vascular cognitive impairment (VCI) clinically, especially in the presence of mixed pathologies, such as vascular and amyloid. Most recently, two criteria (American Heart Association/American Stroke Association [AHA/ASA] and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-V]) have been proposed for the clinical diagnosis of VCI but have not as yet been validated using neuroimaging. AIMS: This study aims to determine whether the AHA/ASA and DSM-V criteria for VCI can distinguish between cases with predominantly vascular pathology and cases with mixed pathology...
April 23, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#4
JOURNAL ARTICLE
Anirudh Wodeyar, Dhinakaran Chinappen, Dimitris Mylonas, Bryan Baxter, Dara S Manoach, Uri T Eden, Mark A Kramer, Catherine J Chu
In severe epileptic encephalopathies, epileptic activity contributes to progressive cognitive dysfunction. Epileptic encephalopathies share the trait of spike-wave activation during non-rapid eye movement sleep (EE-SWAS), a sleep stage dominated by sleep spindles, brain oscillations known to coordinate offline memory consolidation. Epileptic activity has been proposed to hijack the circuits driving these thalamocortical oscillations, thereby contributing to cognitive impairment. Using a unique dataset of simultaneous human thalamic and cortical recordings in subjects with and without EE-SWAS, we provide evidence for epileptic spike interference of thalamic sleep spindle production in patients with EE-SWAS...
April 23, 2024: Brain
#5
JOURNAL ARTICLE
Joël Macoir, Pascale Tremblay, Stéphanie Beaudoin, Mathias Parent, Carol Hudon
Subjective cognitive decline (SCD) may serve as an early indicator of Alzheimer's disease (AD). However, accurately quantifying cognitive impairment in SCD is challenging, mainly because existing assessment tools lack sensitivity. This study examined how tasks specifically designed to assess knowledge of famous people, could potentially aid in identifying cognitive impairment in SCD. A total of 60 adults with SCD and 60 healthy controls (HCs) aged 50 to 82 years performed a famous people verbal fluency task and a famous people naming task...
April 22, 2024: Applied Neuropsychology. Adult
#6
JOURNAL ARTICLE
Tanja Sikjaer, Simon Fristed Eskildsen, Line Underbjerg, Leif Østergaard, Lars Rejnmark, Lars Evald
Hypoparathyroidism (HypoPT) is a disease with no/or inadequate production/secretion of parathyroid hormone (PTH) from the parathyroid glands. Low levels of PTH result in hypocalcemia, which is often treated with calcium supplementation and active vitamin-D analogs. However, increasing evidence suggests that HypoPT has a profound impact on several organ systems. Quality of life (QOL) is reduced in patients with HypoPT, partly due to symptoms related to the central nervous system-including subjective feelings of confusion, a reduced ability to focus and think clearly(i...
April 22, 2024: Journal of Bone and Mineral Research
#7
JOURNAL ARTICLE
Zihao Li, Meini Wu, Changhao Yin, Zhenqi Wang, Jianhang Wang, Lingyu Chen, Weina Zhao
BACKGROUND: Vascular cognitive impairment (VCI) is a major cause of cognitive impairment in the elderly and a co-factor in the development and progression of most neurodegenerative diseases. With the continuing development of neuroimaging, multiple markers can be combined to provide richer biological information, but little is known about their diagnostic value in VCI. METHODS: A total of 83 subjects participated in our study, including 32 patients with vascular cognitive impairment with no dementia (VCIND), 21 patients with vascular dementia (VD), and 30 normal controls (NC)...
2024: Frontiers in Aging Neuroscience
#8
JOURNAL ARTICLE
Hussein A Hussein, Mohamed Kahloul, Majid F Alhamaidah, Hussein J Alkhfaji
BACKGROUND: Preoperative anxiety in children has been linked to various postoperative consequences, such as postoperative regressive behavioral issues, extended distress during the recovery period, eating disorders, and bedwetting. The current study aimed to investigate the efficacy of low-dose oral melatonin in alleviating preoperative anxiety among children in the Iraqi population. STUDY DESIGN: A randomized, double-blinded comparative study was undertaken, involving children aged four to 14 years scheduled for elective cardiac catheterization under general anesthesia...
March 2024: Curēus
#9
JOURNAL ARTICLE
Jingnan Sun, Zengmai Xie, Yike Sun, Anruo Shen, Renren Li, Xiao Yuan, Bai Lu, Yunxia Li
Alzheimer's disease (AD) constitutes a neurodegenerative disorder marked by a progressive decline in cognitive function and memory capacity. The accurate diagnosis of this condition predominantly relies on cerebrospinal fluid (CSF) markers, notwithstanding the associated burdens of pain and substantial financial costs endured by patients. This study encompasses subjects exhibiting varying degrees of cognitive impairment, encompassing individuals with subjective cognitive decline, mild cognitive impairment, and dementia, constituting a total sample size of 82 participants...
May 2024: MedComm
#10
Morgan Holcomb, Austin Marshall, Hannah Flinn, Mariana Lozano, Sirena Soriano, Fernando Gomez-Pinilla, Todd J Treangen, Sonia Villapol
Background Recent studies have shed light on the potential role of gut dysbiosis in shaping traumatic brain injury (TBI) outcomes. Changes in the levels and types of Lactobacillus bacteria present might impact the immune system disturbances, neuroinflammatory responses, anxiety and depressive-like behaviors, and compromised neuroprotection mechanisms triggered by TBI. Objective This study aimed to investigate the effects of a daily pan-probiotic (PP) mixture in drinking water containing strains of Lactobacillus plantarum, L...
April 2, 2024: Research Square
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JOURNAL ARTICLE
Kamilla Woznica Miskowiak, Tue Krebs Roikjer, Johanna Mariegaard, Johanne Lilmose Bech, Zacharias Kalle Obel, Birgitte Vejstrup, Line Hansen, Lars Vedel Kessing
Bipolar disorder (BD) is often accompanied by persistent cognitive impairment. However, screening for cognitive impairment in the clinic is challenged by a lack of consensus on screening procedures. This study assesses cognitive impairment prevalence and screening feasibility in alignment with the International Society for Bipolar Disorder Targeting Cognition Task Force recommendations. Between January 2022 and May 2023, 136 newly diagnosed BD outpatients were assessed with the Screen for Cognitive Impairment in Psychiatry after 15-20 months of specialised care at the Copenhagen Affective Disorder Clinic...
April 20, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
#12
JOURNAL ARTICLE
Qian Liu, Fang Wang, Lixia Tan, Li Liu, Xiuying Hu
INTRODUCTION: Subjective cognitive decline means a decline in the subjective perception of self-cognitive function, which is likely to evolve into mild cognitive impairment and dementia. The number of elderly with subjective cognitive decline has increased, bringing huge burdens and challenges to caregivers and society. With the increase in research on art therapies, some of them have gradually been proven to be effective for cognitive function. Therefore, this study aims to summarise the evidence and identify the best art therapy for elderly with subjective cognitive decline...
April 19, 2024: BMJ Open
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REVIEW
Margaret F Bedillion, Eric D Claus, Stephanie E Wemm, Helen C Fox, Emily B Ansell
Over 75% of young adults who use cannabis also report drinking alcohol, leading to increased risks that include impaired cognition, substance use disorders, and more heavy and frequent substance use. Studies suggest that subjective responses to either alcohol or cannabis can serve as a valuable indicator for identifying individuals at risk of prolonged substance use and use disorder. While laboratory studies show additive effects when alcohol and cannabis are used together, the impact of co-using these substances, specifically with respect to cannabidiol, on an individual's subjective experience remains unclear...
April 19, 2024: Alcohol Clin Exp Res (Hoboken)
#14
JOURNAL ARTICLE
Rui Mo, Man Jiang, Hongwei Xu, Ruzhen Jia
BACKGROUND: Recent clinical studies have yielded controversial results regarding the effect of probiotics on cognitive function in Alzheimer's disease (AD) or mild cognitive impairment (MCI) subjects. To clarify the efficacy of probiotics on cognition, we conducted a meta-analysis of randomized controlled trials (RCTs). METHODS: Instructions of the PRISMA 2020 statement were followed. Literature from the PubMed, Embase and Cochrane databases were systematically searched and manually screened for relevant published RCTs...
April 18, 2024: Medicina Clínica
#15
JOURNAL ARTICLE
Jenni Radun, Henna Maula, Iida-Kaisa Tervahartiala, Ville Rajala, Sabine Schlittmeier, Valtteri Hongisto
Irrelevant speech impairs cognitive performance, especially in tasks requiring verbal short-term memory. Working on these tasks during irrelevant speech can also cause a physiological stress reaction. The aim of this study was to examine heart rate variability (HRV) as a non-invasive and easy-to-use stress measure in an irrelevant speech paradigm. Thirty participants performed cognitive tasks (n-back and serial recall) during two sound conditions: irrelevant speech (50 dB) and quiet (33 dB steady-state noise)...
April 17, 2024: International Journal of Psychophysiology
#16
JOURNAL ARTICLE
Marco Ceccanti, Laura Libonati, Federica Moret, Edoardo D'Andrea, Maria Cristina Gori, Francesco Saverio Bersani, Maurizio Inghilleri, Chiara Cambieri
OBJECTIVE: The aim of our study was to measure the ability of ALS patients to process dynamic facial expressions as compared to a control group of healthy subjects and to correlate this ability in ALS patients with neuropsychological, clinical and neurological measures of the disease. METHODS: Sixty-three ALS patients and 47 healthy controls were recruited. All the ALS patients also underwent i) the Geneva Emotion Recognition Test (GERT) in which ten actors express 14 types of dynamic emotions in brief video clips with audio, ii) the Edimburgh Cognitive and Behavioral ALS Screen (ECAS) test; iii) the ALS Functional Rating Scale Revised (ALSFRS-R) and iv) the Medical Research Council (MRC) for the evaluation of muscle strength...
April 16, 2024: Journal of the Neurological Sciences
#17
JOURNAL ARTICLE
Giovanni Sighinolfi, Micaela Mitolo, Fabrizio Pizzagalli, Michelangelo Stanzani-Maserati, Daniel Remondini, Magali Jane Rochat, Elena Cantoni, Greta Venturi, Gianfranco Vornetti, Fiorina Bartiromo, Sabina Capellari, Rocco Liguori, Caterina Tonon, Claudia Testa, Raffaele Lodi
BACKGROUND: Being able to differentiate mild cognitive impairment (MCI) patients who would eventually convert (MCIc) to Alzheimer's disease (AD) from those who would not (MCInc) is a key challenge for prognosis. OBJECTIVE: This study aimed to investigate the ability of sulcal morphometry to predict MCI progression to AD, dedicating special attention to an accurate identification of sulci. METHODS: Twenty-five AD patients, thirty-seven MCI and twenty-five healthy controls (HC) underwent a brain-MR protocol (1...
April 17, 2024: Journal of Alzheimer's Disease: JAD
#18
JOURNAL ARTICLE
Ganesh Chandrasekaran, Sharon X Xie
BACKGROUND: Missing data is prevalent in the Alzheimer's Disease Neuroimaging Initiative (ADNI). It is common to deal with missingness by removing subjects with missing entries prior to statistical analysis; however, this can lead to significant efficiency loss and sometimes bias. It has yet to be demonstrated that the imputation approach to handling this issue can be valuable in some longitudinal regression settings. OBJECTIVE: The purpose of this study is to demonstrate the importance of imputation and how imputation is correctly done in ADNI by analyzing longitudinal Alzheimer's Disease Assessment Scale -Cognitive Subscale 13 (ADAS-Cog 13) scores and their association with baseline patient characteristics...
April 17, 2024: Journal of Alzheimer's Disease: JAD
#19
JOURNAL ARTICLE
Luwen Cao, Kunmei Han, Li Lin, Jiawen Hing, Vincent Ooi, Nick Huang, Junhong Yu, Ted Kheng Siang Ng, Lei Feng, Rathi Mahendran, Ee Heok Kua, Zhiming Bao
INTRODUCTION: Patients with Alzheimer's disease present with difficulty in lexical retrieval and reversal of the concreteness effect in nouns. Little is known about the phenomena before the onset of symptoms. We anticipate early linguistic signs in the speech of people who suffer from amnestic mild cognitive impairment (MCI). Here, we report the results of a corpus-linguistic approach to the early detection of cognitive impairment. METHODS: One hundred forty-eight English-speaking Singaporeans provided natural speech data, on topics of their choice; 74 were diagnosed with single-domain MCI (38 amnestic, 36 non-amnestic), 74 cognitively healthy...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#20
JOURNAL ARTICLE
Alyssa N Kaser, Laura H Lacritz, Holly R Winiarski, Peru Gabirondo, Jeff Schaffert, Alberto J Coca, Javier Jiménez-Raboso, Tomas Rojo, Carla Zaldua, Iker Honorato, Dario Gallego, Emmanuel Rosario Nieves, Leslie D Rosenstein, C Munro Cullum
OBJECTIVE: Early detection of cognitive impairment in the elderly is crucial for diagnosis and appropriate care. Brief, cost-effective cognitive screening instruments are needed to help identify individuals who require further evaluation. This study presents preliminary data on a new screening technology using automated voice recording analysis software in a Spanish population. METHOD: Data were collected from 174 Spanish-speaking individuals clinically diagnosed as cognitively normal (CN, n = 87) or impaired (mild cognitive impairment [MCI], n = 63; all-cause dementia, n = 24)...
2024: Frontiers in Neurology
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