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Subjective cognitive impairment

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https://www.readbyqxmd.com/read/29166387/effects-of-total-sleep-deprivation-on-divided-attention-performance
#1
Eric Chern-Pin Chua, Eric Fang, Joshua J Gooley
Dividing attention across two tasks performed simultaneously usually results in impaired performance on one or both tasks. Most studies have found no difference in the dual-task cost of dividing attention in rested and sleep-deprived states. We hypothesized that, for a divided attention task that is highly cognitively-demanding, performance would show greater impairment during exposure to sleep deprivation. A group of 30 healthy males aged 21-30 years was exposed to 40 h of continuous wakefulness in a laboratory setting...
2017: PloS One
https://www.readbyqxmd.com/read/29165083/subjective-spatial-navigation-complaints-a-frequent-symptom-reported-by-patients-with-subjective-cognitive-decline-mild-cognitive-impairment-and-alzheimer-s-disease
#2
Cerman Jiri, Andel Ross, Laczo Jan, Vyhnalek Martin, Nedelska Zuzana, Mokrisova Ivana, Sheardova Katerina, Hort Jakub
BACKGROUND: Great effort has been put into developing simple and feasible tools capable to detect Alzheimer's disease (AD) in its early clinical stage. Spatial navigation impairment occurs very early in AD and is detectable even in the stage of mild cognitive impairment (MCI). OBJECTIVE: The aim was to describe the frequency of self-reported spatial navigation complaints in patients with subjective cognitive decline (SCD), amnestic and non-amnestic MCI (aMCI, naMCI) and AD dementia and to assess whether a simple questionnaire based on these complaints may be used to detect early AD...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29165082/easy-screening-for-mild-alzheimer-s-disease-and-mild-cognitive-impairment-from-elderly-speech
#3
Shohei Kato, Akira Homma, Takuto Sakuma
OBJECTIVE: This study presents a novel approach for early detection of cognitive impairment in the elderly. The approach incorporates the use of speech sound analysis, multivariate statistics, and data-mining techniques. We have developed a speech prosody-based cognitive impairment rating (SPCIR) that can distinguish between cognitively normal controls and elderly people with mild Alzheimer's disease (mAD) or mild cognitive impairment (MCI) using prosodic signals extracted from elderly speech while administering a questionnaire...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29165049/are-latent-variable-models-preferable-to-composite-score-approaches-when-assessing-risk-factors-of-change-evaluation-of-type-i-error-and-statistical-power-in-longitudinal-cognitive-studies
#4
Cécile Proust-Lima, Viviane Philipps, Jean-François Dartigues, David A Bennett, M Maria Glymour, Hélène Jacqmin-Gadda, Cécilia Samieri
As with many health constructs, cognition is difficult to measure accurately; it is assessed by multiple psychometric tests. Two approaches are commonly adopted to address this multivariate aspect in longitudinal analyses: the composite score approach summarizes the tests into a single outcome and subsequently analyzes its change; the multivariate approach relates the tests to the underlying cognitive level and simultaneously analyzes its change. We compared the quality of inference of these approaches in a simulation study based on three combinations of tests inspired by two population-based cohorts...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29164115/cross-sectional-associations-of-fatigue-with-cerebral-%C3%AE-amyloid-in-older-adults-at-risk-of-dementia
#5
Claudie Hooper, Philipe De Souto Barreto, Nicola Coley, Matteo Cesari, Pierre Payoux, Anne Sophie Salabert, Sandrine Andrieu, Bruno Vellas
Fatigue is a common symptom in the elderly and has also been associated with impaired cognition in older adults. Hence, we sought to explore the cross-sectional relationship between fatigue and cerebral β-amyloid (Aβ) in 269 elderly individuals reporting subjective memory complaints from the Multidomain Alzheimer Preventive Trial. Standard uptake value ratios (SUVRs) were generated by [(18)F] florbetapir positron emission tomography (PET) using the cerebellum as a reference. Cortical-to-cerebellar SUVRs (cortical-SUVRs) were obtained using the mean signal from the frontal cortex, temporal cortex, parietal cortex, precuneus, anterior cingulate, and posterior cingulate...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29164042/different-effects-of-cognitive-and-non-exercise-physical-leisure-activities-on-cognitive-function-by-age-in-elderly-korean-individuals
#6
Mi Sook Jung, Hyunli Kim, Yeji Lee, Mijung Kim, Eunyoung Chung
Objectives: We aimed to examine the effects of various leisure activities on cognitive impairment in young-old (aged 65-74 years) and old-old (aged ≥ 75 years) adults. Methods: In total, 10,279 elderly Korean individuals from the 2014 Korean National Survey on Older Adults' cohort were enrolled in our study. Cognitive impairment was assessed using the standardized score of the Mini-Mental State Examination for Dementia Screening, whereas leisure activities were recorded via self-reporting of the extent and type of leisure activity the subjects involved in over the past year...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29163162/a-randomized-double-blinded-clinical-trial-on-effects-of-a-vitis-vinifera-extract-on-cognitive-function-in-healthy-older-adults
#7
Gioacchino Calapai, Francesco Bonina, Andrea Bonina, Luisa Rizza, Carmen Mannucci, Vincenzo Arcoraci, Germana Laganà, Angela Alibrandi, Concetta Pollicino, Santi Inferrera, Umberto Alecci
Introduction: Gradual population aging is creating a new set of needs in the general population. Memory capacity decreases with age, and memory deficits are considered an early symptom of Alzheimer's Disease (AD), one of the most prevalent cognitive disorders in older people. Numerous studies have shown that grape polyphenolic compounds (GPs) are able to attenuate cognitive impairment and reduce brain lesions in experimental AD animal models. These GP effects are associated with improvement in brain antioxidant status and prevention of free radical-induced neuronal damage...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163142/low-serum-phosphorus-correlates-with-cerebral-a%C3%AE-deposition-in-cognitively-impaired-subjects-results-from-the-kbase-study
#8
Jong-Chan Park, Sun-Ho Han, Min S Byun, Dahyun Yi, Jun Ho Lee, Kyua Park, Dong Young Lee, Inhee Mook-Jung
Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29162753/assessment-of-pain-in-the-elderly-a-literature-review
#9
REVIEW
Yoon-Sook Kim, Jae-Min Park, Yeon-Sil Moon, Seol-Heui Han
BACKGROUND: Pain perception is highly subjective, and effective pain management can be challenging in the elderly. We aimed to identify a set of practical measures that could be used to assess pain in elderly patients with or without cognitive impairment, as the first step towards effectively managing their pain. METHODS: We used the PRISMA guidelines for this literature review. Two reviewers independently assessed titles, abstracts and full-text articles, and a third reviewer resolved any disagreements...
July 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29161919/the-effects-of-adhd-on-cognitive-performance
#10
Emma Claesdotter, Matti Cervin, Sofia Åkerlund, Maria Råstam, Magnus Lindvall
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is a common and impairing neurodevelopmental disorder. The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized test battery with standardized procedures and solid psychometric properties targeting multiple neuropsychological functions. AIMS: The aim of this study was to look at the effects of ADHD on cognitive performance using CANTAB expressed as a statistical interaction term in regression modeling...
November 21, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29160817/impact-of-high-dose-multi-strain-probiotic-supplementation-on-neurocognitive-performance-and-central-nervous-system-immune-activation-of-hiv-1-infected-individuals
#11
Giancarlo Ceccarelli, Jason M Brenchley, Eugenio Nelson Cavallari, Giuseppe Corano Scheri, Mariangela Fratino, Claudia Pinacchio, Ivan Schietroma, Saeid Najafi Fard, Carolina Scagnolari, Ivano Mezzaroma, Vincenzo Vullo, Gabriella d'Ettorre
BACKGROUND: Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data are available on the impairment of the gut-brain axis, despite neurocognitive disorders being commonly diagnosed in these patients. This study evaluated the impact of a probiotic supplementation strategy on intrathecal immune activation and cognitive performance in combined antiretroviral therapy (cART) treated HIV-1 infected subjects...
November 21, 2017: Nutrients
https://www.readbyqxmd.com/read/29160740/effects-of-regular-physical-activity-on-the-cognitive-performance-of-type-2-diabetic-patients-a-systematic-review
#12
Natalie Podolski, Klara Brixius, Hans G Predel, Christian Brinkmann
BACKGROUND: Cognitive decline has been shown to be associated with long-term type 2 diabetes mellitus (T2DM). This review analyzes the present literature to ascertain the role of regular physical activity (PA) for the functioning of the diabetic brain. METHODS: PubMed was systematically searched for relevant publications up to July 2017. RESULTS: Four cross-sectional, one longitudinal observational, and nine interventional studies with a total of ∼7000 T2DM subjects are included in this review...
November 21, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29160010/effects-of-a-short-midday-nap-on-habitual-nappers-alertness-mood-and-mental-performance-across-cognitive-domains
#13
Taotao Ru, Qingwei Chen, Jianing You, Guofu Zhou
This study examines whether the benefits of a short midday nap on habitual nappers' mental performance depend on the cognitive domain and the task difficulty. Eighteen healthy college students with the long-term habit of a midday nap (13:00-14:00 hours) participated in a nap-deprivation study. On two separate days with at least 3 days in between, participants either took a nap or remained awake, and were subsequently tested on a simple sustained attention task (Psychomotor Vigilance Test), two more complex attention tasks (Go/No-Go and Flanker task) and one working memory task (2-back)...
November 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29159907/the-ability-to-self-monitor-cognitive-performance-during-60%C3%A2-h-total-sleep-deprivation-and-following-2%C3%A2-nights-recovery-sleep
#14
Johanna M Boardman, Bei Bei, Alix Mellor, Clare Anderson, Tracey L Sletten, Sean P A Drummond
We aimed to investigate whether self-monitoring of performance is altered during 60 h of total sleep deprivation, following 2 nights of recovery sleep, and by task difficulty and/or subjective sleepiness. Forty adults (22 females, aged 19-39 years) underwent a 5-day protocol, with a well-rested day, 66 h total sleep deprivation (last test session at 60 h), and 2 nights of 8 h recovery sleep. An arithmetic task (MATH) with three difficulty levels assessed working memory. The Psychomotor Vigilance Task assessed sustained attention...
November 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29159812/the-i-in-autism-severity-and-social-functioning-in-autism-are-related-to-self-processing
#15
Karri Gillespie-Smith, Carrie Ballantyne, Holly P Branigan, David J Turk, Sheila J Cunningham
It is well established that children with autism spectrum disorder (ASD) show impaired understanding of others and deficits within social functioning. However, it is still unknown whether self-processing is related to these impairments and to what extent self impacts social functioning and communication. Using an ownership paradigm, we show that children with ASD and chronological- and verbal-age-matched typically developing (TD) children do show the self-referential effect in memory. In addition, the self-bias was dependent on symptom severity and socio-communicative ability...
November 21, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/29159268/olfactory-identification-in-subjective-cognitive-decline-and-mild-cognitive-impairment-association-with-tau-but-not-amyloid-positron-emission-tomography
#16
Shannon L Risacher, Eileen F Tallman, John D West, Karmen K Yoder, Gary D Hutchins, James W Fletcher, Sujuan Gao, David A Kareken, Martin R Farlow, Liana G Apostolova, Andrew J Saykin
Introduction: We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Methods: Thirty-four older adults, including 19 cognitively normal (CN), 10 subjective cognitive decline (SCD), and 5 mild cognitive impairment, underwent amyloid positron emission tomography, magnetic resonance imaging, and the University of Pennsylvania Smell Identification Test (UPSIT). Twenty-six also underwent tau positron emission tomography...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29159056/no-association-of-cortical-amyloid-load-and-eeg-connectivity-in-older-people-with-subjective-memory-complaints
#17
Stefan Teipel, Hovagim Bakardjian, Gabriel Gonzalez-Escamilla, Enrica Cavedo, Sarah Weschke, Martin Dyrba, Michel J Grothe, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Harald Hampel
Changes in functional connectivity of cortical networks have been observed in resting-state EEG studies in healthy aging as well as preclinical and clinical stages of AD. Little information, however, exists on associations between EEG connectivity and cortical amyloid load in people with subjective memory complaints. Here, we determined the association of global cortical amyloid load, as measured by florbetapir-PET, with functional connectivity based on the phase-lag index of resting state EEG data for alpha and beta frequency bands in 318 cognitively normal individuals aged 70-85 years with subjective memory complaints from the INSIGHT-preAD cohort...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159047/voxel-based-comparison-of-brain-glucose-metabolism-between-patients-with-cushing-s-disease-and-healthy-subjects
#18
Shuai Liu, Yinyan Wang, Kaibin Xu, Fan Ping, Fang Li, Renzhi Wang, Xin Cheng
Cognitive impairment and psychiatric symptoms are common in patients with Cushing's disease (CD) owing to elevated levels of glucocorticoids. Molecular neuroimaging methods may help to detect changes in the brain of patients with CD. The aim of this study was to investigate the characteristics of brain metabolism and its association with serum cortisol level in CD. We compared brain metabolism, as measured using [(18)F]-fluorodeoxyglucose positron emission tomography (FDG PET), between 92 patients with CD and 118 normal subjects on a voxel-wise basis...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159044/a-key-role-of-the-prefrontal-cortex-in-the-maintenance-of-chronic-tinnitus-an-fmri-study-using-a-stroop-task
#19
Rodrigo Araneda, Laurent Renier, Laurence Dricot, Monique Decat, Daniela Ebner-Karestinos, Naïma Deggouj, Anne G De Volder
Introduction: Since we recently showed in behavioural tasks that the top-down cognitive control was specifically altered in tinnitus sufferers, here we wanted to establish the link between this impaired executive function and brain alterations in the frontal cortex in tinnitus patients. Method: Using functional magnetic resonance imaging (fMRI), we monitored the brain activity changes in sixteen tinnitus patients (TP) and their control subjects (CS) while they were performing a spatial Stroop task, both in audition and vision...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29158880/effect-of-mild-cognitive-impairment-and-alzheimer-disease-on-auditory-steady-state-responses
#20
Elaheh Shahmiri, Zahra Jafari, Maryam Noroozian, Azadeh Zendehbad, Hassan Haddadzadeh Niri, Ali Yoonessi
Introduction: Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. Methods: In this study, the thresholds of Auditory Steady-State Response (ASSR) to 40 Hz and 80 Hz were compared between Alzheimer Disease (AD), MCI, and control groups...
July 2017: Basic and Clinical Neuroscience
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