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R Agnese, T Aramaki, I J Arnquist, W Baker, D Balakishiyeva, S Banik, D Barker, R Basu Thakur, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, D O Caldwell, R Calkins, C Cartaro, D G Cerdeño, Y Chang, Y Chen, J Cooley, B Cornell, P Cushman, M Daal, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, M Fritts, G Gerbier, R Germond, M Ghaith, G L Godfrey, S R Golwala, J Hall, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, A Jastram, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, K Page, W A Page, R Partridge, M Penalver Martinez, M Pepin, A Phipps, S Poudel, M Pyle, H Qiu, W Rau, P Redl, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, T Saab, B Sadoulet, J Sander, K Schneck, R W Schnee, S Scorza, K Senapati, B Serfass, D Speller, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, B Welliver, J S Wilson, M J Wilson, D H Wright, S Yellin, J J Yen, B A Young, X Zhang, X Zhao
We report the result of a blinded search for weakly interacting massive particles (WIMPs) using the majority of the SuperCDMS Soudan data set. With an exposure of 1690 kg d, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP-nucleon cross section of 1.4×10^{-44} (1.0×10^{-44})  cm^{2} at 46  GeV/c^{2}. These results set the strongest limits for WIMP-germanium-nucleus interactions for masses >12  GeV/c^{2}...
February 9, 2018: Physical Review Letters
Margaret M MacDonell, Richard C Hertzberg, Glenn E Rice, J Michael Wright, Linda K Teuschler
In assessing environmental health risks, the risk characterization step synthesizes information gathered in evaluating exposures to stressors together with dose-response relationships, characteristics of the exposed population, and external environmental conditions. This article summarizes key steps of a cumulative risk assessment (CRA) followed by a discussion of considerations for characterizing cumulative risks. Cumulative risk characterizations differ considerably from single chemical- or single source-based risk characterization...
November 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
C W MacDonell, K E Power, J W Chopek, K R Gardiner, P F Gardiner
This study examined motoneurone properties during fictive locomotion in the adult rat for the first time. Fictive locomotion was induced via electrical stimulation of the mesencephalic locomotor region in decerebrate adult rats under neuromuscular blockade to compare basic and rhythmic motoneurone properties in antidromically identified extensor motoneurones during: (1) quiescence, before and after fictive locomotion; (2) the 'tonic' period immediately preceding locomotor-like activity, whereby the amplitude of peripheral flexor (peroneal) and extensor (tibial) nerves are increased but alternation has not yet occurred; and (3) locomotor-like episodes...
May 15, 2015: Journal of Physiology
T Firoz, L A Magee, K MacDonell, B A Payne, R Gordon, M Vidler, P von Dadelszen
BACKGROUND: Pregnant and postpartum women with severe hypertension are at increased risk of stroke and require blood pressure (BP) reduction. Parenteral antihypertensives have been most commonly studied, but oral agents would be ideal for use in busy and resource-constrained settings. OBJECTIVES: To review systematically, the effectiveness of oral antihypertensive agents for treatment of severe pregnancy/postpartum hypertension. SEARCH STRATEGY: A systematic search of MEDLINE, EMBASE and the Cochrane Library was performed...
September 2014: BJOG: An International Journal of Obstetrics and Gynaecology
Kristy Macdonell, Kristen Christie, Kate Robson, Kasia Pytlik, Shoo K Lee, Karel OʼBrien
The purpose of this article is to describe and evaluate how "veteran" parents were engaged as experts in the design and implementation of a family-integrated care program in a Canadian neonatal intensive care unit (NICU). Three parents of preterm infants previously discharged from the NICU participated in the design and implementation of a family-integrated care pilot program. The steering committee for the program included 5 staff members (a physician, a NICU nurse, a parent education nurse, a lactation consultant, and a social worker) and the parent volunteers...
August 2013: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Margaret M Macdonell, Lynne A Haroun, Linda K Teuschler, Glenn E Rice, Richard C Hertzberg, James P Butler, Young-Soo Chang, Shanna L Clark, Alan P Johns, Camarie S Perry, Shannon S Garcia, John H Jacobi, Marcienne A Scofield
The historical approach to assessing health risks of environmental chemicals has been to evaluate them one at a time. In fact, we are exposed every day to a wide variety of chemicals and are increasingly aware of potential health implications. Although considerable progress has been made in the science underlying risk assessments for real-world exposures, implementation has lagged because many practitioners are unaware of methods and tools available to support these analyses. To address this issue, the US Environmental Protection Agency developed a toolbox of cumulative risk resources for contaminated sites, as part of a resource document that was published in 2007...
2013: Journal of Toxicology
Karel O'Brien, Marianne Bracht, Kristy Macdonell, Tammy McBride, Kate Robson, Lori O'Leary, Kristen Christie, Mary Galarza, Tenzin Dicky, Adik Levin, Shoo K Lee
BACKGROUND: We have developed a Family Integrated Care (FIC) model for use in a neonatal intensive care unit (NICU) where parents provide most of the care for their infant, while nurses teach and counsel parents. The objective of this pilot prospective cohort analytic study was to explore the feasibility, safety, and potential outcomes of implementing this model in a Canadian NICU. METHODS: Infants born ≤ 35 weeks gestation, receiving continuous positive airway pressure or less respiratory support, with a primary caregiver willing and able to spend ≥ 8 hours a day with their infant were eligible...
2013: BMC Pregnancy and Childbirth
Benjamin K-T Tsang, Nicholas Crump, Richard A Macdonell
We describe a 35 year-old man presenting with a four-week history of non-painful limb paraesthesias and unsteady gait causing falls. On examination he had an ataxic gait associated with dorsal column sensory loss. He had a medical history of a partial gastrectomy six years prior and anaemia. He had received monthly intramuscular hydroxycobalamin injections since the gastrectomy. Laboratory tests revealed normal vitamin B12 and holotranscobalamin levels, a reduced serum caeruloplasmin of 0.05 g/L (normal: 0...
June 2012: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Benjamin K-T Tsang, Richard Macdonell
BACKGROUND: Multiple sclerosis is the most common chronic disabling disease of the central nervous system in young adults. OBJECTIVE: This article summarises the diagnosis, management and prognosis of multiple sclerosis. DISCUSSION: Multiple sclerosis usually starts with an acute episode of neurological disturbance, termed a 'clinically isolated syndrome', followed by an illness phase punctuated by relapses and remissions which may transition after 10 years to a phase of progressive accumulation of disability without relapses...
December 2011: Australian Family Physician
Amanda G Thrift, Helen M Dewey, Jonathan W Sturm, Velandai K Srikanth, Amanda K Gilligan, Seana L Gall, Richard A L Macdonell, John J McNeil, Geoffrey A Donnan
BACKGROUND AND PURPOSE: Incidence rates of stroke subtypes may be imprecise when samples are small. We aimed to determine the incidence of stroke subtypes in a large geographically defined population. METHODS: Multiple overlapping sources were used to ascertain all strokes occurring in 22 postcodes (population of 306,631) of Melbourne, Australia, between 1997 and 1999. Stroke subtypes were defined by CT, MRI and autopsy. The Mantel-Haenszel age-adjusted rate ratio (MH RR) was used to compare incidence rates between men and women...
2009: Neuroepidemiology
D Lütjohann, K von Bergmann, W Sirah, G Macdonell, A O Johnson-Levonas, A Shah, J Lin, A Sapre, T Musliner
OBJECTIVE: To assess the long-term efficacy and safety profile of ezetimibe 10 mg/day in patients with homozygous sitosterolemia. METHODS: This was an extension of a multi-centre, randomised, double-blind, placebo-controlled base study in which patients with homozygous sitosterolemia and plasma sitosterol concentrations > 5 mg/dl were randomised 4 : 1 to ezetimibe 10 mg/day (n = 30) or placebo (n = 7) for 8 weeks. Patients who successfully completed the base study with > 80% compliance to study medication were eligible to enter two, successive, 1-year extension studies in which ezetimibe 10 mg/day was administered in an open-label manner...
October 2008: International Journal of Clinical Practice
Samuel F Berkovic, Leanne M Dibbens, Alicia Oshlack, Jeremy D Silver, Marina Katerelos, Danya F Vears, Renate Lüllmann-Rauch, Judith Blanz, Ke Wei Zhang, Jim Stankovich, Renate M Kalnins, John P Dowling, Eva Andermann, Frederick Andermann, Enrico Faldini, Rudi D'Hooge, Lata Vadlamudi, Richard A Macdonell, Bree L Hodgson, Marta A Bayly, Judy Savige, John C Mulley, Gordon K Smyth, David A Power, Paul Saftig, Melanie Bahlo
Action myoclonus-renal failure syndrome (AMRF) is an autosomal-recessive disorder with the remarkable combination of focal glomerulosclerosis, frequently with glomerular collapse, and progressive myoclonus epilepsy associated with storage material in the brain. Here, we employed a novel combination of molecular strategies to find the responsible gene and show its effects in an animal model. Utilizing only three unrelated affected individuals and their relatives, we used homozygosity mapping with single-nucleotide polymorphism chips to localize AMRF...
March 2008: American Journal of Human Genetics
D L Stoner, C K Browning, D K Bulmer, T E Ward, M T Macdonell
This study demonstrates the efficacy of a direct 5S rRNA assay for the characterization of mixed microbial populations by using as an example the bacteria associated with acidic mining environments. The direct 5S rRNA assay described herein represents a nonselective, direct molecular method for monitoring and characterizing the predominant, metabolically active members of a microbial population. The foundation of the assay is high-resolution denaturing gradient gel electrophoresis (DGGE), which is used to separate 5S rRNA species extracted from collected biomass...
June 1996: Applied and Environmental Microbiology
Amanda G Thrift, Helen M Dewey, Jonathan W Sturm, Seana L Paul, Amanda K Gilligan, Velandai K Srikanth, Richard A L Macdonell, John J McNeil, Malcolm R Macleod, Geoffrey A Donnan
BACKGROUND AND PURPOSE: Greater stroke mortality has been reported among lower socioeconomic groups. We aimed to determine whether fatal, nonfatal, and overall stroke incidence varied by socioeconomic status. METHODS: All suspected strokes occurring in 22 postcodes (population of 306,631) of Melbourne, Australia, during a 24-month period between 1997 and 1999 were found and assessed. Multiple overlapping sources were used to ascertain cases with standard clinical definitions for stroke...
March 2006: Stroke; a Journal of Cerebral Circulation
Amanda K Gilligan, Amanda G Thrift, Jonathan W Sturm, Helen M Dewey, Richard A L Macdonell, Geoffrey A Donnan
BACKGROUND: Although a number of acute stroke interventions are of proven efficacy, there is uncertainty about their community benefits. We aimed to assess this within a defined population. METHODS: Eligibility for tissue plasminogen activator (tPA), aspirin, stroke unit management and neuroprotection were assessed among incident stroke cases within the community-based North East Melbourne Stroke Incidence Study. RESULTS: Among 306,631 people, there were 645 incident strokes managed in hospital...
2005: Cerebrovascular Diseases
V K Srikanth, J F I Anderson, G A Donnan, M M Saling, E Didus, R Alpitsis, H M Dewey, R A L Macdonell, A G Thrift
OBJECTIVES: To examine the risk and determinants of a progressive dementia syndrome and cognitive impairment not dementia (CIND) in community-based nonaphasic first-ever stroke cases 1 year after stroke, relative to a matched community-based stroke-free group. METHODS: Matched cohort design, with cognitive tests given on two occasions 9 months apart to 99 mild-to-moderate first-ever stroke patients and 99 age- and sex-matched people without stroke. At follow-up, progressive dementia or CIND were diagnosed, with judges blinded to stroke/nonstroke status...
September 14, 2004: Neurology
Jonathan W Sturm, Geoffrey A Donnan, Helen M Dewey, Richard A L Macdonell, Amanda K Gilligan, Velandai Srikanth, Amanda G Thrift
BACKGROUND AND PURPOSE: Health-related quality of life (HRQoL) data are scarce from unselected populations. The aims were to assess HRQoL at 2 years poststroke, to identify determinants of HRQoL in stroke survivors, and to identify predictors at stroke onset of subsequent HRQoL. METHODS: All first-ever cases of stroke in a population of 306 631 over a 1-year period were assessed. Stroke severity, comorbidity, and demographic information were recorded. Two-year poststroke HRQoL was assessed using the Assessment of Quality of Life (AQoL) instrument (deceased patients score=0)...
October 2004: Stroke; a Journal of Cerebral Circulation
Jonathan W Sturm, Geoffrey A Donnan, Helen M Dewey, Richard A L Macdonell, Amanda K Gilligan, Amanda G Thrift
BACKGROUND AND PURPOSE: Handicap, although more relevant to the patient than impairment or disability, has received little attention in people with stroke. The aim of this study was to identify, in an unselected population, factors determining handicap at 2 years after stroke. METHODS: All first-ever cases of stroke in a population of 306 631 over a 1-year period were assessed. Stroke severity, comorbidity, and demographic information was recorded. Among survivors, 2-year poststroke handicap was assessed with the London Handicap Scale...
March 2004: Stroke; a Journal of Cerebral Circulation
Velandai K Srikanth, Amanda G Thrift, Michael M Saling, Jacqueline F I Anderson, Helen M Dewey, Richard A L Macdonell, Geoffrey A Donnan
BACKGROUND AND PURPOSE: Results of hospital-based studies indicate a high risk of cognitive impairment 3 months after stroke. There are no comprehensive data on this issue from prospective community-based studies comparing first-ever stroke patients with stroke-free subjects. METHODS: We administered a comprehensive neuropsychological battery to 99 community-based nonaphasic survivors of first-ever stroke at 3 months and 99 age- and sex-matched (1:1) stroke-free individuals...
May 2003: Stroke; a Journal of Cerebral Circulation
L E MacDonell, F K Skinner, P E Ward, A I Glen, A C Glen, D J Macdonald, R M Boyle, D F Horrobin
Research findings are increasingly reporting evidence of physiological abnormalities in dyslexia and sites for dyslexia have been identified on three chromosomes. It has been suggested that genetic inheritance may cause phospholipid abnormalities in dyslexia somewhat similar to those found in schizophrenia. A key enzyme in phospholipid metabolism, Type IV, or cytosolic, phospholipase A2 (cPLA2), releases arachidonic acid (AA), a 20-carbon fatty acid, which is the major source of production of prostaglandins and leukotrienes...
July 2000: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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