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JOURNAL ARTICLE
Caitlin S Sayegh, Ellen Iverson, Karen K MacDonell, Shinyi Wu, Marvin Belzer
OBJECTIVE: We applied a Supportive Accountability Model lens to understand how youth view remote human coaching versus automated reminders targeting medication adherence. METHODS: We used thematic analysis to interpret (N = 22) youths' responses to semi-structured interviews after 12 weeks of mobile health intervention. RESULTS: Participants reported that both coaching and automated reminders prompted them to take medication, improving their adherence...
November 21, 2023: Patient Education and Counseling
#2
JOURNAL ARTICLE
Sifat Sharmin, Izanne Roos, Steve Simpson-Yap, Charles Malpas, Marina M Sánchez, Serkan Ozakbas, Dana Horakova, Eva K Havrdova, Francesco Patti, Raed Alroughani, Guillermo Izquierdo, Sara Eichau, Cavit Boz, Magd Zakaria, Marco Onofrj, Alessandra Lugaresi, Bianca Weinstock-Guttman, Alexandre Prat, Marc Girard, Pierre Duquette, Murat Terzi, Maria Pia Amato, Rana Karabudak, Francois Grand'Maison, Samia J Khoury, Pierre Grammond, Jeannette Lechner-Scott, Katherine Buzzard, Olga Skibina, Anneke van der Walt, Helmut Butzkueven, Recai Turkoglu, Ayse Altintas, Davide Maimone, Allan Kermode, Nevin Shalaby, Vincent V Pesch, Ernest Butler, Youssef Sidhom, Riadh Gouider, Saloua Mrabet, Oliver Gerlach, Aysun Soysal, Michael Barnett, Jens Kuhle, Stella Hughes, Maria J Sa, Suzanne Hodgkinson, Celia Oreja-Guevara, Radek Ampapa, Thor Petersen, Cristina Ramo-Tello, Daniele Spitaleri, Pamela McCombe, Bruce Taylor, Julie Prevost, Matteo Foschi, Mark Slee, Chris McGuigan, Guy Laureys, Liesbeth V Hijfte, Koen de Gans, Claudio Solaro, Jiwon Oh, Richard Macdonell, Eduardo Aguera-Morales, Bhim Singhal, Orla Gray, Justin Garber, Bart V Wijmeersch, Mihaela Simu, Tamara Castillo-Triviño, Jose L Sanchez-Menoyo, Dheeraj Khurana, Abdullah Al-Asmi, Talal Al-Harbi, Norma Deri, Yara Fragoso, Patrice H Lalive, L G F Sinnige, Cameron Shaw, Neil Shuey, Tunde Csepany, Angel P Sempere, Fraser Moore, Danny Decoo, Barbara Willekens, Claudio Gobbi, Jennifer Massey, Todd Hardy, John Parratt, Tomas Kalincik
Geographical variations in the incidence and prevalence of multiple sclerosis have been reported globally. Latitude as a surrogate for exposure to ultraviolet radiation but also other lifestyle and environmental factors are regarded as drivers of this variation. No previous studies evaluated geographical variation in the risk of secondary progressive multiple sclerosis, an advanced form of multiple sclerosis that is characterized by steady accrual of irreversible disability. We evaluated differences in the risk of secondary progressive multiple sclerosis in relation to latitude and country of residence, modified by high-to-moderate efficacy immunotherapy in a geographically diverse cohort of patients with relapsing-remitting multiple sclerosis...
November 2, 2023: Brain
#3
JOURNAL ARTICLE
Sylvie Naar, M Isabel Fernandez, Lisa Todd, Sara K Shaw Green, Henna Budhwani, April Carcone, Karin Coyle, Gregory A Aarons, Karen MacDonell, Gary W Harper
BACKGROUND: Understanding the barriers and facilitators of implementation completion is critical to determining why some implementation efforts fail and some succeed. Such studies provide the foundation for developing further strategies to support implementation completion when scaling up evidence-based practices (EBPs) such as Motivational Interviewing. METHOD: This mixed-methods study utilized the Exploration, Preparation, Implementation, and Sustainment framework in an iterative analytic design to compare adolescent HIV clinics that demonstrated either high or low implementation completion in the context of a hybrid Type III trial of tailored motivational interviewing...
2023: Implementation research and practice
#4
JOURNAL ARTICLE
Caitlin S Sayegh, Ellen Iverson, Karen K MacDonell, Amy E West, Marvin Belzer
BACKGROUND: Randomized clinical trials (RCTs) enrolling pediatric populations often struggle with recruitment. Engaging healthcare providers in the recruitment process may increase patients' and caregivers' willingness to participate in research. The purpose of this study was to understand the perspectives of pediatric subspecialty healthcare providers considering recruiting patients to participate in an mobile health (mHealth) RCT. METHODS: We conducted 9 semi-structured interviews and 1 focus group with a total of N = 11 providers from various disciplines before the initiation of an mHealth RCT addressing medication nonadherence...
June 2023: Contemporary Clinical Trials Communications
#5
REVIEW
Denise J Wooding, Thalia S Field, Stephan K W Schwarz, Su-Yin MacDonell, Jaycee Farmer, Shobana Rajan, Alana M Flexman
Perioperative complications such as stroke, delirium, and neurocognitive dysfunction are common and responsible for increased morbidity and mortality. Our objective was to characterize and synthesize the contemporary guidelines on perioperative brain health for noncardiac, non-neurologic surgery in a scoping review. We performed a structured search for articles providing recommendations on brain health published between 2016 and 2021 and included the following complications: perioperative stroke and perioperative neurocognitive disorders, the latter of which encompasses postoperative delirium and a spectrum of postoperative cognitive dysfunction...
January 1, 2023: Journal of Neurosurgical Anesthesiology
#6
JOURNAL ARTICLE
Charles V Yu, Julena Foglia, Paul Yen, Trina Montemurro, Stephan K W Schwarz, Su-Yin MacDonell
PURPOSE: Noise in the operating room (OR) is common and associated with negative effects on anesthesiologists, surgeons, and patient outcomes. Induction of anesthesia is among the loudest perioperative periods. Despite its critical nature, there is little data on noise levels during induction, associated patient and anesthesiologist satisfaction, and the effects of noise reduction strategies. METHODS: We conducted a two-part prospective interventional quality improvement project on the care of adult patients receiving general anesthesia for elective noncardiac surgery...
April 2022: Canadian Journal of Anaesthesia
#7
JOURNAL ARTICLE
Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M Prain, Mark Woodhall, Roger Silvestrini, Christine S Bundell, David A Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J Brew, Wallace Brownlee, Helmut Butzkueven, William M Carroll, Cella Chen, Alan Coulthard, Russell C Dale, Chandi Das, Marzena J Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P D Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J Kilpatrick, John King, Christopher Kneebone, Andrew J Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A L Macdonell, Deborah F Mason, Pamela A McCombe, Jennifer Pereira, John D Pollard, Sudarshini Ramanathan, Stephen W Reddel, Cameron P Shaw, Judith M Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C Wong, Eppie M Yiu, Michael H Barnett, Allan G K Kermode, Mark P Marriott, John D E Parratt, Mark Slee, Bruce V Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A Broadley
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search...
2021: Frontiers in Neurology
#8
JOURNAL ARTICLE
I Alkhatib, D W P Amaral, T Aralis, T Aramaki, I J Arnquist, I Ataee Langroudy, E Azadbakht, S Banik, D Barker, C Bathurst, D A Bauer, L V S Bezerra, R Bhattacharyya, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, R Calkins, R A Cameron, C Cartaro, D G Cerdeño, Y-Y Chang, M Chaudhuri, R Chen, N Chott, J Cooley, H Coombes, J Corbett, P Cushman, F De Brienne, M L di Vacri, M D Diamond, E Fascione, E Figueroa-Feliciano, C W Fink, K Fouts, M Fritts, G Gerbier, R Germond, M Ghaith, S R Golwala, H R Harris, N Herbert, B A Hines, M I Hollister, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, A Jastram, V K S Kashyap, M H Kelsey, A Kubik, N A Kurinsky, R E Lawrence, A Li, B Loer, E Lopez Asamar, P Lukens, D MacDonell, D B MacFarlane, R Mahapatra, V Mandic, N Mast, A J Mayer, H Meyer Zu Theenhausen, É M Michaud, E Michielin, N Mirabolfathi, B Mohanty, J D Morales Mendoza, S Nagorny, J Nelson, H Neog, V Novati, J L Orrell, S M Oser, W A Page, P Pakarha, R Partridge, R Podviianiuk, F Ponce, S Poudel, M Pyle, W Rau, E Reid, R Ren, T Reynolds, A Roberts, A E Robinson, T Saab, B Sadoulet, J Sander, A Sattari, R W Schnee, S Scorza, B Serfass, D J Sincavage, C Stanford, J Street, D Toback, R Underwood, S Verma, A N Villano, B von Krosigk, S L Watkins, L Wills, J S Wilson, M J Wilson, J Winchell, D H Wright, S Yellin, B A Young, T C Yu, E Zhang, H G Zhang, X Zhao, L Zheng, J Camilleri, Yu G Kolomensky, S Zuber
We present limits on spin-independent dark matter-nucleon interactions using a 10.6 g Si athermal phonon detector with a baseline energy resolution of σ_{E}=3.86±0.04(stat)_{-0.00}^{+0.19}(syst) eV. This exclusion analysis sets the most stringent dark matter-nucleon scattering cross-section limits achieved by a cryogenic detector for dark matter particle masses from 93 to 140 MeV/c^{2}, with a raw exposure of 9.9 g d acquired at an above-ground facility. This work illustrates the scientific potential of detectors with athermal phonon sensors with eV-scale energy resolution for future dark matter searches...
August 6, 2021: Physical Review Letters
#9
MULTICENTER STUDY
Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, J William L Brown, Dana Horakova, Eva K Havrdova, Maria Trojano, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Marco Onofrj, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Grammond, Patrizia Sola, Diana Ferraro, Serkan Ozakbas, Roberto Bergamaschi, Maria José Sá, Elisabetta Cartechini, Cavit Boz, Franco Granella, Raymond Hupperts, Murat Terzi, Jeannette Lechner-Scott, Daniele Spitaleri, Vincent Van Pesch, Aysun Soysal, Javier Olascoaga, Julie Prevost, Eduardo Aguera-Morales, Mark Slee, Tunde Csepany, Recai Turkoglu, Youssef Sidhom, Riadh Gouider, Bart Van Wijmeersch, Pamela McCombe, Richard Macdonell, Alasdair Coles, Charles B Malpas, Helmut Butzkueven, Sandra Vukusic, Tomas Kalincik
In multiple sclerosis, treatment start or switch is prompted by evidence of disease activity. Whilst immunomodulatory therapies reduce disease activity, the time required to attain maximal effect is unclear. In this study we aimed to develop a method that allows identification of the time to manifest fully and clinically the effect of multiple sclerosis treatments ('therapeutic lag') on clinical disease activity represented by relapses and progression-of-disability events. Data from two multiple sclerosis registries, MSBase (multinational) and OFSEP (French), were used...
September 1, 2020: Brain
#10
JOURNAL ARTICLE
Sylvie Naar, Gabriel Robles, Karen Kolmodin MacDonell, Veronica Dinaj-Koci, Kit N Simpson, Phebe Lam, Jeffrey T Parsons, K Marie Sizemore, Tyrel J Starks
Importance: Youth living with HIV make up one-quarter of new infections and have high rates of risk behaviors but are significantly understudied. Effectiveness trials in real-world settings are needed to inform program delivery. Objective: To compare the effectiveness of the Healthy Choices intervention delivered in a home or community setting vs a medical clinic. Design, Setting, and Participants: This randomized clinical trial was conducted from November 1, 2014, to January 31, 2018, with 52 weeks of follow-up...
August 3, 2020: JAMA Network Open
#11
JOURNAL ARTICLE
Nataly Raviv, Michael D Staudt, Andrew K Rock, Jacquelyn MacDonell, Julia Slyer, Julie G Pilitsis
BACKGROUND: Obsessive compulsive disorder (OCD) is a complex neuropsychiatric disease characterized by obsessions and compulsions. Deep brain stimulation (DBS) has demonstrated efficacy in improving symptoms in medically refractory patients. Multiple targets have been investigated. OBJECTIVE: To systematically review the current level and quality of evidence supporting OCD-DBS by target region with the goal of establishing a common nomenclature. METHODS: A systematic literature review was performed using the PubMed database and a patient/problem, intervention, comparison, outcome search with the terms "DBS" and "OCD...
July 2, 2020: Neurosurgery
#12
JOURNAL ARTICLE
Genome sequence of Shewanella corallii strain A687 isolated from pufferfish (Sphoeroides spengleri).
Gustavo P R Azevedo, Pedro H C da Paz, Hannah K Mattsson, Ana Paula B Moreira, Luciana Leomil, Gabriela Calegário, Luciana Appolinario, Lívia Vidal, Bruno S Silva, Luciane A Chimetto Tonon, Diogo A Tschoeke, Gizele D Garcia, Fabiano L Thompson, Cristiane C Thompson
We present here the genome sequence of Shewanella corallii strain A687 isolated from pufferfish Sphoeroides spengleri (Family Tetraodontidae). The assembly consists of 5,215,037 bp and contains 284 contigs, with a G+C content of 50.3%.
2020: Genetics and Molecular Biology
#13
R Agnese, T Aralis, T Aramaki, I J Arnquist, E Azadbakht, W Baker, S Banik, D Barker, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, R Calkins, C Cartaro, D G Cerdeño, Y-Y Chang, J Cooley, B Cornell, P Cushman, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, C Fink, M Fritts, G Gerbier, R Germond, M Ghaith, S R Golwala, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, R E Lawrence, J V Leyva, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, W A Page, R Partridge, M Pepin, A Phipps, F Ponce, S Poudel, M Pyle, H Qiu, W Rau, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, R K Romani, T Saab, B Sadoulet, J Sander, A Scarff, R W Schnee, S Scorza, K Senapati, B Serfass, J So, D Speller, C Stanford, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, S L Watkins, J S Wilson, M J Wilson, J Winchell, D H Wright, S Yellin, B A Young, X Zhang, X Zhao
This corrects the article DOI: 10.1103/PhysRevLett.121.051301.
February 15, 2019: Physical Review Letters
#14
JOURNAL ARTICLE
April Idalski Carcone, Mehedi Hasan, Gwen L Alexander, Ming Dong, Susan Eggly, Kathryn Brogan Hartlieb, Sylvie Naar, Karen MacDonell, Alexander Kotov
Objective: The goal of this research is to develop a machine learning supervised classification model to automatically code clinical encounter transcripts using a behavioral code scheme. Methods: We first evaluated the efficacy of eight state-of-the-art machine learning classification models to recognize patient-provider communication behaviors operationalized by the motivational interviewing framework. Data were collected during the course of a single weight loss intervention session with 37 African American adolescents and their caregivers...
January 29, 2019: Journal of Pediatric Psychology
#15
JOURNAL ARTICLE
R Agnese, T Aralis, T Aramaki, I J Arnquist, E Azadbakht, W Baker, S Banik, D Barker, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, R Calkins, C Cartaro, D G Cerdeño, Y-Y Chang, J Cooley, B Cornell, P Cushman, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, C Fink, M Fritts, G Gerbier, R Germond, M Ghaith, S R Golwala, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, R E Lawrence, J V Leyva, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, W A Page, R Partridge, M Pepin, A Phipps, F Ponce, S Poudel, M Pyle, H Qiu, W Rau, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, R K Romani, T Saab, B Sadoulet, J Sander, A Scarff, R W Schnee, S Scorza, K Senapati, B Serfass, J So, D Speller, C Stanford, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, S L Watkins, J S Wilson, M J Wilson, J Winchell, D H Wright, S Yellin, B A Young, X Zhang, X Zhao
We present the first limits on inelastic electron-scattering dark matter and dark photon absorption using a prototype SuperCDMS detector having a charge resolution of 0.1 electron-hole pairs (CDMS HVeV, a 0.93 g CDMS high-voltage device). These electron-recoil limits significantly improve experimental constraints on dark matter particles with masses as low as 1 MeV/c^{2}. We demonstrate a sensitivity to dark photons competitive with other leading approaches but using substantially less exposure (0.49 g d)...
August 3, 2018: Physical Review Letters
#16
JOURNAL ARTICLE
Caitlin S Sayegh, Karen K MacDonell, Leslie F Clark, Nadia L Dowshen, Sylvie Naar, Johanna Olson-Kennedy, Jacob J van den Berg, Jiahong Xu, Marvin Belzer
Mobile health interventions to promote adherence to antiretroviral therapy among adolescents and young adults living with HIV represent a promising strategy. This pilot study (N = 37) evaluated the psychosocial impacts of an efficacious adherence intervention, cell phone support (CPS). Participants receiving CPS reported significant decreases in perceived stress, depression, and illicit substance use, and increases in self-efficacy during at least one study assessment period, in comparison to participants receiving usual care...
October 2018: AIDS and Behavior
#17
RANDOMIZED CONTROLLED TRIAL
S Mall, J Noakes, M Kossoff, W Lee, M McKessar, A Goy, J Duncombe, M Roberts, B Giuffre, A Miller, N Bhola, C Kapoor, C Shearman, G DaCosta, S Choi, J Sterba, M Kay, K Bruderlin, N Winarta, K Donohue, B Macdonell-Scott, F Klijnsma, K Suzuki, P Brennan, C Mello-Thoms
PURPOSE: To compare the efficacy of use of digital breast tomosynthesis (DBT) with standard digital mammography (DM) workup views in the breast cancer assessment clinic. MATERIALS AND METHODS: The Tomosynthesis Assessment Clinic trial (TACT), conducted between 16 October 2014 and 19 April 2016, is an ethics-approved, monocenter, multireader, multicase split-plot reading study. After written informed consent was obtained, 144 females (age > 40 years) who were recalled to the assessment clinic were recruited into TACT...
December 2018: European Radiology
#18
JOURNAL ARTICLE
R Agnese, T Aramaki, I J Arnquist, W Baker, D Balakishiyeva, S Banik, D Barker, R Basu Thakur, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, D O Caldwell, R Calkins, C Cartaro, D G Cerdeño, Y Chang, Y Chen, J Cooley, B Cornell, P Cushman, M Daal, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, M Fritts, G Gerbier, R Germond, M Ghaith, G L Godfrey, S R Golwala, J Hall, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, A Jastram, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, K Page, W A Page, R Partridge, M Penalver Martinez, M Pepin, A Phipps, S Poudel, M Pyle, H Qiu, W Rau, P Redl, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, T Saab, B Sadoulet, J Sander, K Schneck, R W Schnee, S Scorza, K Senapati, B Serfass, D Speller, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, B Welliver, J S Wilson, M J Wilson, D H Wright, S Yellin, J J Yen, B A Young, X Zhang, X Zhao
We report the result of a blinded search for weakly interacting massive particles (WIMPs) using the majority of the SuperCDMS Soudan data set. With an exposure of 1690 kg d, a single candidate event is observed, consistent with expected backgrounds. This analysis (combined with previous Ge results) sets an upper limit on the spin-independent WIMP-nucleon cross section of 1.4×10^{-44} (1.0×10^{-44}) cm^{2} at 46 GeV/c^{2}. These results set the strongest limits for WIMP-germanium-nucleus interactions for masses >12 GeV/c^{2}...
February 9, 2018: Physical Review Letters
#19
JOURNAL ARTICLE
Margaret M MacDonell, Richard C Hertzberg, Glenn E Rice, J Michael Wright, Linda K Teuschler
In assessing environmental health risks, the risk characterization step synthesizes information gathered in evaluating exposures to stressors together with dose-response relationships, characteristics of the exposed population, and external environmental conditions. This article summarizes key steps of a cumulative risk assessment (CRA) followed by a discussion of considerations for characterizing cumulative risks. Cumulative risk characterizations differ considerably from single chemical- or single source-based risk characterization...
June 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
#20
COMPARATIVE STUDY
C W MacDonell, K E Power, J W Chopek, K R Gardiner, P F Gardiner
This study examined motoneurone properties during fictive locomotion in the adult rat for the first time. Fictive locomotion was induced via electrical stimulation of the mesencephalic locomotor region in decerebrate adult rats under neuromuscular blockade to compare basic and rhythmic motoneurone properties in antidromically identified extensor motoneurones during: (1) quiescence, before and after fictive locomotion; (2) the 'tonic' period immediately preceding locomotor-like activity, whereby the amplitude of peripheral flexor (peroneal) and extensor (tibial) nerves are increased but alternation has not yet occurred; and (3) locomotor-like episodes...
May 15, 2015: Journal of Physiology
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