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https://www.readbyqxmd.com/read/28936478/recurrence-rate-of-melanoma-in-situ-when-treated-with-serial-disk-staged-excision-a-case-series
#1
Daniel Garcia, Robert E Eilers, S Brian Jiang
BACKGROUND: Cutaneous melanoma is one of the fastest rising cancer diagnoses in recent years. Melanoma in situ (MIS) constitutes a large proportion of all diagnosed melanomas. While surgical excision is considered the standard of therapy, the literature is not clear on which surgical technique minimizes local recurrence. A common technique is serial staged excision (SSE), in which a series of mapped excisions are made according to histopathological examination of tissue. Previously published recurrence rates for SSE ranges from 0-12%, over a range of 4...
February 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28936477/clinical-characteristics-of-non-melanoma-skin-cancers-recurring-within-5-years-after-mohs-micrographic-surgery-single-institution-retrospective-chart-review
#2
Tina Vajdi, Robert Eilers, Shang I Brian Jiang
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat certain high-risk non-melanoma skin cancers (NMSC) due to its high cure rate. However, clinical recurrences do occur in a small number of cases. OBJECTIVE: We examined specific clinical characteristics associated with NMSC recurrences following MMS. METHODS: We employed a retrospective chart review of the 1467 cases of NMSC that underwent MMS at UC San Diego from January 1, 2008 through December 31, 2009...
January 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28935274/a-matter-of-margins-surgical-and-pathologic-risk-factors-for-recurrence-in-extramammary-paget-s-disease
#3
Beverly Long, Adam R Schmitt, Amy L Weaver, Michaela McGree, Jamie N Bakkum-Gamez, Jerry Brewer, William A Cliby
OBJECTIVES: To determine surgical and pathologic variables associated with recurrence in extramammary Paget's disease (EMPD). METHODS: Medical records of patients seeking care for EMPD from 1/1992-9/2015 were reviewed. Follow-up was restricted to 5years following primary surgery. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method. Risk factors were evaluated for an association with recurrence and positive margins, respectively, using Cox proportional hazards regression and logistic regression...
September 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28934979/human-resources-for-health-in-peru-recent-trends-2007-2013-in-the-labour-market-for-physicians-nurses-and-midwives
#4
M Michelle Jimenez, Anthony L Bui, Eduardo Mantilla, J Jaime Miranda
BACKGROUND: Most analyses of gaps in human resources for health (HRH) do not consider training and the transition of graduates into the labour market. This study aims to explore the labour market for Peru's recent medical, nursing, and midwifery graduates as well as their transition into employment in the Ministry of Health's (MOH) system. METHODS: Data from four different datasets, covering 2007-2013, was used to characterize the patterns of recently trained physicians, nurses, midwives, and postgraduate-trained physicians that enter employment in the MOH system, and scenario analyses were used to describe how this rate of entry needs to adapt in order to fill current HRH shortages...
September 21, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28931417/sentinel-lymph-node-biopsy-in-periocular-merkel-cell-carcinoma-a-case-report
#5
Dan C Filitis, Gyorgy Paragh, Faramarz H Samie, Nathalie C Zeitouni
BACKGROUND: The National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic. CASE PRESENTATION: We present a case of a Caucasian patient in their seventies who presented with a 1...
September 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28930791/polydactylous-bowen-s-disease-in-an-immunocompromised-patient-resolution-of-all-lesions-after-mohs-surgery-on-a-single-lesion
#6
Nikita S Goel, Rajat Varma, Daniel C Zedek, Puneet S Jolly
No abstract text is available yet for this article.
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28930787/use-of-google-trends-to-examine-interest-in-mohs-micrographic-surgery-2004-to-2016
#7
Daniel J Callaghan
BACKGROUND: Mohs micrographic surgery (MMS) is the gold standard for treatment of high-risk skin cancers. There has been an upward trend in the use of this procedure as demonstrated by data from Medicare and the National Ambulatory Medical Care Survey. OBJECTIVE: To assess interest in MMS among members of the general public as measured by number of online searches, and how that interest has changed over time. MATERIALS AND METHODS: Google Trends was used to plot interest in search terms including "Mohs surgery," "basal cell carcinoma," "squamous cell carcinoma," "melanoma," and "skin cancer" from January 1, 2004, to November 30, 2016...
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28917477/using-a-slit-knife-to-facilitate-mohs-micrographic-surgery-in-irregularly-shaped-areas
#8
José Francisco Millán-Cayetano, Inés Fernández-Canedo, Alberto Ortega-Sánchez, Magdalena de Troya-Martín
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28905698/microbulbifer-aggregans-sp-nov-isolated-from-estuarine-sediment-from-a-mangrove-forest
#9
Tsu Horng Moh, Go Furusawa, Abdullah Al-Ashraf Amirul
A novel, rod-shaped, Gram-stain-negative, halophilic and non-motile bacterium, designated CCB-MM1T, was isolated from a sample of estuarine sediment collected from Matang Mangrove Forest, Malaysia. The cells possessed a rod-coccus cell cycle in association with growth phase and formed aggregates. Strain CCB-MM1T was both catalase and oxidase positive, and able to degrade starch. Optimum growth occurred at 30 °C and pH 7.0 in the presence of 2-3 % (w/v) NaCl. The 16S rRNA gene sequence of strain CCB-MM1T showed 98...
September 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28903584/re-how-mohs-surgery-transformed-into-a-first-line-treatment-of-skin-cancer
#10
Evert Tuyp
No abstract text is available yet for this article.
July 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28899738/angiomyomatous-hamartoma-of-lymph-nodes-revisited-clinico-pathologic-study-of-21-cases-emphasizing-its-distinction-from-lymphangioleiomyomatosis-of-lymph-nodes
#11
Michelle Moh, Ankur Sangoi, Joseph T Rabban
Angiomyomatous hamartoma of lymph nodes (AMH-LN) is an uncommon benign proliferation of smooth muscle, blood vessels, collagenous stroma and adipocytes, most commonly affecting inguinal LN. A similar constellation of cell types constitutes various members of the perivascular epithelioid cell tumor (PEComa) family, including lymphangioleiomyomatosis (LAM) which can involve LN in women. Because some LN-LAM patients have tuberous sclerosis complex (TSC) and/or other PEComa family lesions, it is clinically relevant to distinguish LN-LAM from AMH-LN...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28899101/retention-of-qualified-healthcare-workers-in-rural-senegal-lessons-learned-from-a-qualitative-study
#12
Mari Nagai, Noriko Fujita, Ibrahima S Diouf, Malick Salla
INTRODUCTION: Deployment and retention of a sufficient number of skilled and motivated human resources for health (HRH) at the right place and at the right time are critical to ensure people's right to access a universal quality of health care. Vision Tokyo 2010 Network, an international network of HRH managers at the ministry of health (MoH) level in nine Francophone African countries, identified maldistribution of a limited number of healthcare personnel and their retention in rural areas as overarching problems in the member countries...
July 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28898467/mohs-micrographic-surgery-in-the-elderly-comparison-of-tumours-surgery-and-first-year-follow-up-in-patients-younger-and-older-than-80-years-old-in-regesmohs
#13
C Camarero-Mulas, Y Delgado Jiménez, O Sanmartín-Jiménez, J R Garcés, M A Rodríguez-Prieto, T Alonso-Alonso, R Miñano Medrano, J L López-Estebaranz, E de Eusebio Murillo, P Redondo, C Ciudad-Blanco, A Toll-Abelló, J L Artola Igarza, I Allende Markixana, R Suarez Fernández, A Alfaro Rubio, M L Alonso Pacheco, H Vázquez-Veiga, P de la Cueva Dobao, V Ruiz-Salas, E Vilarrasa Rull, L Barchino, V Morales-Gordillo, I Ocerin-Guerra, R Navarro Tejedor, L Hueso, M Mayor Arenal, M J Seoane-Pose, N Cano-Martinez, I Garcia-Doval, M A Descalzo
BACKGROUND: The elderly population is increasing and more patients in this group undergo Mohs micrographic surgery. The few publications investigating MMS in elderly people conclude that it is a safe procedure; however, these are single centre studies without a comparison group. OBJECTIVE: To compare the characteristics of patients, tumours, MMS, and one-year follow-up in patients younger than 80 years, with patients older than 80 years at the time of surgery. METHODS: Data was analysed from REGESMOHS, a prospective cohort study of patients treated with MMS...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28893632/patients-experiences-with-extramammary-paget-s-disease-an-online-pilot-study-querying-a-patient-support-group
#14
Paul H Chung, Jeremy T Kampp, Bryan B Voelzke
OBJECTIVE: To illustrate the heterogeneous care delivered to patients with Extramammary Paget's Disease (EMPD), a rare and lethal malignancy with poorly described treatment methodologies, by characterizing the clinical and pathological characteristics of an international patient support group. METHODS: Institutional review board approval was obtained to develop and distribute a non-validated survey to patients from an international, online EMPD support group. The survey was developed to capture patient clinical and pathological details and was distributed between January 2017 and February 2017...
September 8, 2017: Urology
https://www.readbyqxmd.com/read/28886861/primary-headache-disorders-part-2-tension-type-headache-and-medication-overuse-headache
#15
Gary W Jay, Robert L Barkin
In Part 2 of Primary Headache disorders, we discuss the fourth Primary Headache Disorder, Tension-Type Headache (TTHA). We are again using the ICHD-III (Beta) definitions of such headaches, taking into consideration episodic and chronic TTHA, as well as the presence or absence of pericranial muscle tenderness. We discuss the pathophysiology and pharmacotherapeutic treatment of TTHA, and the aspects of the Myofascial Pain Syndrome that enhance and help the development of TTHA. We then discuss Medication Overuse Headache (MOH), itself a Secondary headache disorder, but one that is extremely important as it assists with the chronification of both migraine and TTHA...
September 5, 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/28885868/evaluating-the-moa-human-relevance-framework-for-f-344-rat-liver-epithelioid-granulomas-with-mineral-oil-hydrocarbons
#16
David Adenuga, Katy Goyak, R Jeffrey Lewis
Toxicology feeding studies of mineral oil hydrocarbons (MOHs), within the carbon number range C22-C28, results in species-specific epithelioid granulomas in the liver of F-344 rats but not in other rat strains, or species. While MOH has been detected, and some pathological effects have been shown to occur in other organs/tissues of F-344 rats and other rat strains/species, it is generally accepted that the effect of toxicological concern is species-specific inflammatory liver granuloma. As oil retention and other MOH-related nontoxic pathological changes in the liver are observed in humans, some have hypothesized that the potential for oil accumulation over a lifetime, through dietary sources, may predispose humans to similar liver effects as observed in F-344 rats...
September 8, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28885148/ultra-wideband-millimeter-wave-dielectric-characteristics-of-freshly-excised-normal-and-malignant-human-skin-tissues
#17
Amir Mirbeik-Sabzevari, Robin Ashinoff, Negar Tavassolian
Millimeter waves have recently gained attention for the evaluation of skin lesions and the detection of skin tumors. Such evaluations heavily rely on the dielectric contrasts existing between normal and malignant skin tissues at millimeter-wave frequencies. However, current studies on the dielectric properties of normal and diseased skin tissues at these frequencies are limited and inconsistent. In this work, a comprehensive dielectric spectroscopy study is conducted for the first time to characterize the ultra-wideband dielectric properties of freshly-excised normal and malignant skin tissues obtained from skin cancer patients having undergone Mohs micrographic surgeries at Hackensack University Medical Center...
September 6, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28880987/association-of-mohs-reconstructive-surgery-timing-with-postoperative-complications
#18
Matthew Q Miller, Abel P David, James E McLean, Stephen S Park, Jared Christophel
Importance: Same-day Mohs reconstructive surgery is not always possible; moreover, a delay can offer benefits such as improved surgical planning and increased blood supply to the cauterized wound bed. However, recent work found that delaying reconstruction by more than 2 days increases the postoperative complication rate. Objective: To review the outcomes of Mohs micrographic surgery (MMS) reconstruction with respect to patient- and surgery-specific variables, especially timing of repair...
September 7, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28879452/methylprednisolone-plus-diazepam-i-v-as-bridge-therapy-for-medication-overuse-headache
#19
Matteo Paolucci, Claudia Altamura, Nicoletta Brunelli, Angelo Cascio Rizzo, Federica Assenza, Patrizio Pasqualetti, Fabrizio Vernieri
Management of medication overuse headache (MOH) requires abrupt suspension of overused drugs either alone or in association with a detoxification protocol to prevent withdrawal. However, there is no consensus about which suspension strategy is the most effective. Moreover, reliable data about the possible mid-term effect of detoxification are not available. The objective of this study was to evaluate whether a bridge therapy consisting of a 5-day i.v. infusion of methylprednisolone and diazepam determines a significant reduction in headache frequency and drug assumption during the detoxification protocol (day 5) and in the first 3 months in patients with MOH...
September 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28877154/a-novel-disease-specific-self-report-instrument-to-measure-body-image-concerns-in-patients-with-head-and-neck-skin-cancer
#20
Brandon T Beal, Emily K White, Anit K Behera, Ashley E McGuinness, Amy E Zavell, Holly Blangger, Eric S Armbrecht, Ian A Maher
BACKGROUND: Skin cancer commonly occurs on areas that are salient to body image perception (i.e., head and neck). Patients with head and neck skin cancer (HNSC) may experience negative body image perceptions related to their disease, which is concerning, given the numerous negative sequelae of poor body image. However, there are no existing disease-specific measures of body image concerns in HNSC. OBJECTIVE: To develop and examine the psychometric properties of a brief self-report, disease-specific measure of body image concerns in patients with HNSC-the Body Image Questionnaire (BIQ)...
September 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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