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https://www.readbyqxmd.com/read/28643465/severe-hemolysis-after-plasma-transfusion-in-a-neonate-with-necrotizing-enterocolitis-clostridium-perfringens-infection-and-red-blood-cell-t-polyagglutination
#1
Julia Moh-Klaren, Gwellaouen Bodivit, Myriam Jugie, Philippe Chadebech, Laurent Chevret, Mostafa Mokhtari, Xavier Chamillard, Philippe Gallon, Pierre Tissières, Philippe Bierling, Rachid Djoudi, France Pirenne, Nicolas Burin-des-Roziers
BACKGROUND: Red blood cell (RBC) Thomsen-Friedenreich antigen exposure (T activation) in infants with necrotizing enterocolitis (NEC) has occasionally been associated with posttransfusional intravascular hemolysis thought to be due to anti-T antibodies in the donor plasma. STUDY DESIGN AND METHODS: We describe an infant with NEC and Clostridium perfringens infection complicated by severe hemolysis after plasma transfusion. After this case, infants with confirmed NEC were prospectively evaluated for T activation...
June 22, 2017: Transfusion
https://www.readbyqxmd.com/read/28635529/major-obstetric-hemorrhage-a-follow-up-survey-on-quality-of-life-of-women-and-their-partners
#2
Giel van Stralen, Laurine L M Ruijten, Ad A Kaptein, Ron Wolterbeek, Jos van Roosmalen
INTRODUCTION: A description is given of the quality of life (QOL) of women who were treated with peripartum embolization or hysterectomy for major obstetric hemorrhage (MOH). METHODS: Questionnaires assessing QOL, combined with questionnaires and drawings assessing illness perceptions, were used to compare women with MOH to reference groups provided by the questionnaires. RESULTS: Women who experienced MOH have similar scores on QOL questionnaires compared to reference groups...
February 9, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28633755/dermatologists-mohs-surgeon
#3
Uc Davis School Of Medicine Dept Of Dermatology
The University of California, Davis, School of Medicine, Department of Dermatology, is recruiting for four academic dermatologists in the Clinical X series or Health Sciences Clinical Professor (HSCP) series at the Assistant/Associate/Professor level based on experience and qualifications. Three of these positions are for general medical dermatologists, and one is for a fellowship-trained Mohs surgeon/procedural dermatologist. The appointments may be made up to 100%.
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28628689/aggressive-skin-cancers-occurring-in-patients-treated-with-the-janus-kinase-inhibitor-ruxolitinib
#4
Adam B Blechman, Christine E Cabell, Christine H Weinberger, Anna Duckworth, Justin J Leitenberger, Fiona O Zwald, Mark A Russell
<p>The Food and Drug Administration approved Ruxolitinib in 2011 for the treatment of primary myelofibrosis. Five-year safety data showed a higher incidence of skin cancer in patients treated with Ruxolitinib compared to best available therapy for myelofibrosis. This report presents a series of five patients with history of myelofibrosis treated with Ruxolitinib who subsequently developed numerous skin cancers with aggressive biological behavior. Each patient in this report was treated by a Mohs surgeon affiliated with an academic institution...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28628682/radiation-therapy-in-dermatology-non-melanoma-skin-cancer
#5
Nikoo Cheraghi, Armand Cognetta, David Goldberg
<p>Background: Dermatologists were historically well versed in the use of radiation therapy for the management of non-melanoma skin cancers and various inflammatory dermatologic conditions. With the advent of Mohs micrographic surgery and therapeutic discoveries for treating inflammatory dermatoses, radiotherapy assumed loss of a role in the clinical repertoire of the dermatologist. In recent years, its importance has again been realized for the management of non-melanoma skin cancers not amenable to surgical treatment or as adjuvant or palliative therapy...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28619614/rapid-ex-vivo-examination-of-mohs-specimens-using-optical-coherence-tomography
#6
D Rashed, D Shah, A Freeman, R J Cook, C Hopper, C M Perrett
BACKGROUND: Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo. OBJECTIVE: The aim of this prospective ex vivo study was to evaluate the efficacy of OCT in recognising healthy and pathological margins of excised BCC lesions and detecting different BCC subtypes...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28615426/modulation-of-intrinsic-resting-state-fmri-networks-in-women-with-chronic-migraine
#7
X Michelle Androulakis, Kaitlin Krebs, B Lee Peterlin, Tianming Zhang, Nasim Maleki, Souvik Sen, Chris Rorden, Priyantha Herath
OBJECTIVE: To evaluate the intrinsic resting functional connectivity of the default mode network (DMN), salience network (SN), and central executive network (CEN) network in women with chronic migraine (CM), and whether clinical features are associated with such abnormalities. METHODS: We analyzed resting-state connectivity in 29 women with CM as compared to age- and sex-matched controls. Relationships between clinical characteristics and changes in targeted networks connectivity were evaluated using a multivariate linear regression model...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28615298/combination-treatment-with-orlistat-containing-nanoparticles-and-taxanes-is-synergistic-and-enhances-microtubule-stability-in-taxane-resistant-prostate-cancer-cells
#8
Joshua J Souchek, Amanda L Davis, Tanner K Hill, Megan B Holmes, Bowen Qi, Pankaj K Singh, Steven J Kridel, Aaron M Mohs
Taxane-based therapy provides a survival benefit in patients with metastatic prostate cancer, yet the median survival is less than 20 months in this setting due in part to taxane-associated resistance. Innovative strategies are required to overcome chemoresistance for improved patient survival. Here, NanoOrl, a new experimental nanoparticle formulation of the FDA-approved drug, orlistat, was investigated for its cytotoxicity in taxane-resistant prostate cancer utilizing two established taxane-resistant (TxR) cell lines...
June 14, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28614565/frederic-edward-mohs-md-the-pioneer-of-chemosurgery
#9
Anshum Sood, Varun Ayyaswami, Arpan V Prabhu, Thomas G Benedek
No abstract text is available yet for this article.
June 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28610408/knowledge-and-awareness-about-cervical-cancer-vaccine-hpv-among-parents-in-sharjah
#10
Ahmad Saqer, Shaymaa Ghazal, Hiba Barqawi, Juman Adnan Babi, Ranya AlKhafaji, Mohamed Mohsen Elmekresh
Background and aim: Cervical cancer (CC) is the 7th most common cancer worldwide. It is the 4th most common cancer in females causing 7.5% of all female cancer deaths. Human Papilloma Virus (HPV) infection is the leading cause of CC and other diseases worldwide. Despite several measures taken to reduce the risk of infection with HPV, the most effective method remains the HPV vaccine. The aim of this study was to assess the knowledge and attitudes of parents in Sharjah towards HPV and whether or not they would vaccinate their daughters...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28607608/clinical-features-pathological-findings-and-treatment-of-recurrent-dermatofibrosarcoma-protuberans
#11
Yanan Li, Chuan Wang, Bo Xiang, Siyuan Chen, Li Li, Yi Ji
Dermatofibrosarcoma protuberans (DESP) is a relatively rare and low-grade tumor of the skin and soft tissue. We review the clinical features, pathological findings and management of recurrent DESP with the aim to improve our understanding of this rare tumor. Fifty-seven patients were diagnosed with recurrent DFSP. The mean age at the presentation of DFSP was 30.9 years. The mean age at diagnosis of DFSP was 40.2 years. Chest wall was the dominant location. The histopathological diagnosis was ordinary DFSP (O-DFSP) in 46 cases and fibrosarcomatous DFSP (FS-DFSP) in 11 cases...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28607243/costing-of-immunization-service-provision-in-kalutara-district-sri-lanka-a-cross-sectional-study
#12
Hemali Jayasekara, Amala De Silva, Ananda Amarasinghe
BACKGROUND: Immunization is regarded as the single most cost-effective way to prevent vaccine-preventable diseases. With the rising cost of the National Immunization Programme (NIP) in Sri Lanka, immunization costing studies could help programme managers to ensure sustainable immunization financing in the country. METHODS: Four medical officer of health (MOH) divisions in Kalutara district were included, to estimate the cost incurred for the NIP programme. Fifteen immunization clinics from urban and rural settings were selected from the selected MOH divisions, by a simple random sampling method...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28605380/establishment-of-a-clinic-based-biorepository
#13
Sarah E Belden, Chandana K Uppalapati, Agnes S Pascual, McKale R Montgomery, Kathryn J Leyva, Elizabeth E Hull, Richard L Averitte
The incidence of skin cancer (e.g., squamous cell carcinoma, basal cell carcinoma, and melanoma) has been increasing over the past several years. It is expected that there will be a parallel demand for cutaneous tumor samples for biomedical research studies. Tissue availability, however, is limited due the cost of establishing a biorepository and the lack of protocols available for obtaining clinical samples that do not interfere with clinical operations. A protocol was established to collect and process cutaneous tumor and associated blood and saliva samples that has minimal impact on routine clinical procedures on the date of a Mohs surgery...
May 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28595252/recurrent-tumors-referred-for-mohs-micrographic-surgery-a-12-year-experience-at-a-single-academic-center
#14
H William Higgins, Sara Capobianco, Kachiu C Lee
BACKGROUND: Mohs micrographic surgery (MMS) is used for treatment of primary and recurrent tumors. Compared with primary tumors, recurrent tumors are often more aggressive. OBJECTIVE: To understand differing characteristics between primary versus recurrent tumors treated by MMS. MATERIALS AND METHODS: The authors conducted a retrospective review of a 12-year period at 1 academic center. Recurrent tumors were defined as recurrent if previously treated with cryotherapy, topical chemotherapeutics, electrodesiccation and curettage, or excision...
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28595247/mohs-melanoma-chemosurgery-simplified-to-a-single-brief-caustic-application-possible-vaccine-effect
#15
Norman A Brooks
No abstract text is available yet for this article.
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28595243/determinants-and-timeline-of-perioperative-anxiety-in-mohs-surgery
#16
Irèn Kossintseva, David Zloty
BACKGROUND: Patients undergoing Mohs micrographic surgery (MMS) exhibit anxiety relating to cancer cure or the expected cosmetic outcome. OBJECTIVE: To obtain quantitative measurements of perioperative cancer and cosmetic anxiety levels in first-time MMS patients. Parameters influencing anxiety and its natural course were assessed. METHODS: Prospective, single-blinded, questionnaire study of 173 patients undergoing MMS of the face. Anxiety levels were assessed using a visual analog scale preoperatively and postoperatively over 6 months...
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28593021/tissue-and-condition-specific-isoforms-of-mammalian-cytochrome-c-oxidase-subunits-from-function-to-human-disease
#17
REVIEW
Christopher A Sinkler, Hasini Kalpage, Joseph Shay, Icksoo Lee, Moh H Malek, Lawrence I Grossman, Maik Hüttemann
Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen. COX consists of 14 subunits, three and eleven encoded, respectively, by the mitochondrial and nuclear DNA. Tissue- and condition-specific isoforms have only been reported for COX but not for the other oxidative phosphorylation complexes, suggesting a fundamental requirement to fine-tune and regulate the essentially irreversible reaction catalyzed by COX. This article briefly discusses the assembly of COX in mammals and then reviews the functions of the six nuclear-encoded COX subunits that are expressed as isoforms in specialized tissues including those of the liver, heart and skeletal muscle, lung, and testes: COX IV-1, COX IV-2, NDUFA4, NDUFA4L2, COX VIaL, COX VIaH, COX VIb-1, COX VIb-2, COX VIIaH, COX VIIaL, COX VIIaR, COX VIIIH/L, and COX VIII-3...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28588290/comparative-epidemiology-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-in-saudi-arabia-and-south-korea
#18
Xin Chen, Abrar Ahmad Chughtai, Amalie Dyda, Chandini Raina MacIntyre
MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012-2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH)...
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28585793/prevalence-and-factors-associated-with-second-eye-cataract-surgery-and-the-trend-in-the-time-interval-between-the-two-eye-surgeries-based-on-the-malaysian-national-eye-database
#19
Shu Fen Ho, Tassha Hilda Bin Adnan, Pik Pin Goh
PURPOSE: To study the prevalence of second eye cataract surgery (SECS), trend in time interval between subsequent surgeries over the years, and factors associated with SECSutilization among patients who underwent cataract surgeries in the Ministry of Health (MOH), Malaysia. DESIGN: Secondary cross-sectional analysis of the Malaysian National Eye Database (NED) data. METHODS: The Malaysian Cataract Surgery Registry collected data on patients who had cataract surgery from 2002-2004 and 2007-2012...
June 1, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28582393/high-correlation-between-framingham-equations-with-bmi-and-with-lipids-to-estimate-cardiovascular-risks-score-at-baseline-in-hiv-infected-adults-in-the-temprano-trial-anrs-12136-in-c%C3%A3-te-d-ivoire
#20
Calixte Ghehi, Delphine Gabillard, Raoul Moh, Anani Badje, Gérard Menan Kouamé, Eric Oouttara, Hugues Ahibo, Jean Baptiste N'Takpé, Jérôme Lecarrou, Serge Paul Eholié, Xavier Anglaret, Christine Danel
CONTEXT: Data on cardiovascular risk (CVR) score among HIV-infected patients in sub-Saharan Africa are scarce. Our first objective was to compare the CVR score of Framingham utilizing BMI and lipids at baseline, and secondary to assess evolution of CVR score over time at Month 30 in the Temprano trial. METHODS: HIV-infected adults with CD4 <800/mm3 without criteria for initiating ART were included and followed for 30 months in the Temprano trial, which assessed the benefits and risks of early antiretroviral treatment (ART) vs deferred ART...
2017: PloS One
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