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https://www.readbyqxmd.com/read/29333949/the-reading-man-flap-for-reconstruction-of-large-periorbital-defects
#1
Elizabeth A Insull, Varajini Joganathan, Jonathan H Norris
PURPOSE: The "reading man" flap (RMF), a double advancement transposition cutaneous flap named for its appearance, has been described in the reconstruction of various circular skin defects, particularly in the malar region. We describe two cases where this flap was used to reconstruct the lower eyelid/periorbital region. METHODS: Two oculoplastic patients with lower eyelid basal cell carcinomas underwent Mohs micrographic excision resulting in a large skin defects...
January 15, 2018: Orbit
https://www.readbyqxmd.com/read/29333918/modified-second-stage-hughes-tarsoconjunctival-reconstruction-for-lower-eyelid-defects
#2
Shruti Aggarwal, Christopher T Shah, Maria Kirzhner
To describe a novel technique utilizing an amniotic membrane graft (AMT) to create the mucocutaneous portion of the lower eyelid margin in a modified Hughes eyelid reconstruction for secondary revision or prevention of a hyperemic, hypertrophic conjunctival margin with excessive discharge. This was a retrospective, non-comparative interventional study. Thirty consecutive patients who underwent a modified Hughes reconstruction were included. The first step of the reconstruction was performed in a standard fashion using a tarsoconjunctival flap from the ipsilateral upper eyelid...
January 15, 2018: Orbit
https://www.readbyqxmd.com/read/29330473/endothelial-heparan-sulfate-deficiency-reduces-inflammation-and-fibrosis-in-murine-diabetic-nephropathy
#3
Ditmer T Talsma, Kirankumar Katta, Marieke A B Ettema, Berna Kel, Marion Kusche-Gullberg, Moh R Daha, Coen A Stegeman, Jacob van den Born, Lianchun Wang
Inflammation plays a vital role in the development of diabetic nephropathy, but the underlying regulatory mechanisms are only partially understood. Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial migration of leukocytes into perivascular tissues by direct interaction with L-selectin and the presentation of bound chemokines. In the current study, we aimed to assess the role of endothelial HS on chronic renal inflammation and fibrosis in a diabetic nephropathy mouse model...
January 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29330276/cutaneous-mycobacterium-massiliense-infection-from-tattooing-a-common-yet-under-reported-and-persistent-epidemic-hazard-for-dermatologists
#4
Lymaries Velez, Jennifer Harb, Stephanie Anuszewski, Stanton Wesson
Tattoo popularity continues to rise, with 3 in 10 Americans bearing at least one. Among tattoo complications, non-tuberculous mycobacteria (NTM) has emerged as a global public health concern. NTM infections associated with tattooing of immunocompetent individuals have occurred as sporadic cases and community outbreaks. Water sources are considered the major pathogenic reservoirs. Tattoo-related inoculation has been linked to contamination of ink, either during the manufacturing process or during dilution of black ink using non-sterile water...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29329503/chemical-imaging-of-aggressive-basal-cell-carcinoma-using-time-of-flight-secondary-ion-mass-spectrometry
#5
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmäki, John Paoli, John S Fletcher
A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface...
January 12, 2018: Biointerphases
https://www.readbyqxmd.com/read/29325740/indocyanine-green-loaded-hyaluronan-derived-nanoparticles-for-fluorescence-enhanced-surgical-imaging-of-pancreatic-cancer
#6
Bowen Qi, Ayrianne J Crawford, Nicholas E Wojtynek, Megan B Holmes, Joshua J Souchek, Graca Almeida-Porada, Quan P Ly, Samuel M Cohen, Michael A Hollingsworth, Aaron M Mohs
Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. In this study, hyaluronic acid derived nanoparticles with physico-chemically entrapped indocyanine green, termed NanoICG, were utilized for intraoperative near infrared fluorescence detection of pancreatic cancer. NanoICG was not cytotoxic to healthy pancreatic epithelial cells and did not induce chemotaxis or phagocytosis, it accumulated significantly within the pancreas in an orthotopic pancreatic ductal adenocarcinoma model, and demonstrated contrast-enhancement for pancreatic lesions relative to non-diseased portions of the pancreas...
January 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29325400/eliminating-healthcare-associated-infections-in-iran-a-qualitative-study-to-explore-stakeholders-views
#7
Atefeh Esfandiari, Hedayat Salari, Arash Rashidian, Hossein Masoumi Asl, Abbas Rahimi Foroushani, Ali Akbari Sari
BACKGROUND: Although preventable, healthcare-associated infections (HAIs) continue to pose huge health and economic burdens on countries worldwide. Some studies have indicated the numerous causes of HAIs, but only a tiny literature exists on the multifaceted measures that can be used to address the problem. This paper presents stakeholders' opinions on measures for controlling HAIs in Iran. METHODS: We used the qualitative research method in studying the phenomenon...
April 15, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29324542/extramammary-paget-disease-of-the-vulva-a-case-series-examining-treatment-recurrence-and-malignant-transformation
#8
Roni Nitecki, Michelle Davis, Jaclyn C Watkins, Yiru E Wu, Allison F Vitonis, Michael G Muto, Ross S Berkowitz, Neil S Horowitz, Colleen M Feltmate
OBJECTIVES: Extramammary Paget disease (EMPD) of the vulva is a rare lesion with a high recurrence rate ranging from 12% to 61%. The rate of underlying adenocarcinoma varies, but in the largest series was reported at 4%. Given the rarity of the disease there is a paucity of data to optimize treatment. This study aims to describe the management and recurrence patterns in a tertiary care setting and to offer suggestions for management in a modern-day setting. METHODS: Patients with pathologically confirmed EMPD treated from 2000 to 2015 were retrospectively identified using an IRB approved database...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29322261/the-journey-from-genetic-predisposition-to-medication-overuse-headache-to-its-acquisition-as-sequela-of-chronic-migraine
#9
EDITORIAL
Paolo Martelletti
Migraine remains one of the biggest clinical case to be solved among the non-communicable diseases, second to low back pain for disability caused as reported by the Global Burden of Disease Study 2016. Despite this, its genetics roots are still unknown. Its evolution in chronic forms hits 2-4% of the population and causes a form so far defined Medication Overuse Headache (MOH), whose pathophysiological basis have not been explained by many dedicated studies. The Global Burden of Disease Study 2016 has not recognized MOH as independent entity, but as a sequela of Chronic Migraine...
January 10, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29321067/the-effects-of-essential-oil-mouthrinses-with-or-without-alcohol-on-plaque-and-gingivitis-a-randomized-controlled-clinical-study
#10
Michael C Lynch, Sheila Cavalca Cortelli, James A McGuire, Jane Zhang, Danette Ricci-Nittel, Carolyn J Mordas, Davi Romeiro Aquino, Jose Roberto Cortelli
BACKGROUND: The efficacy of several variants of essential oil mouthrinses has been studied extensively. This is the first study to compare the anti-plaque and anti-gingivitis efficacy of two marketed essential oil mouthrinses: one is an alcohol containing mouthrinse and the other one is an alcohol-free mouthrinse. METHODS: This examiner-blind, parallel-group study randomized subjects to three groups: 1) Mechanical Oral Hygiene (MOH) only; 2) MOH plus Alcohol-Containing essential oil Mouthrinse (ACM); 3) MOH plus Alcohol-Free essential oil Mouthrinse (AFM)...
January 10, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29315148/examining-the-relevance-to-patients-of-complications-in-the-american-college-of-mohs-surgery-registry-results-of-a-delphi-consensus-process
#11
Jeremy R Etzkorn, Nima M Gharavi, David R Carr, Whitney D Tope, Jeremy S Bordeaux, Ian A Maher
BACKGROUND: Surgical registries are valuable tools for tracking outcomes. Incorporating patient input allows registries to address the interests of this important stakeholder group. OBJECTIVE: The aim of this study was to identify a list of "patient-selected complications" and to explore the relevance to patients of previously published physician-identified complications. METHODS: Delphi process with 2 rounds using patients to identify complications that are highly relevant for tracking by the proposed American College of Mohs Surgery (ACMS) National Registry...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29315146/conjunctival-concretions-found-in-mohs-micrographic-surgery
#12
Michael J Davis, Lauren P Rimoin, Travis W Blalock
No abstract text is available yet for this article.
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29304039/establishing-ebola-virus-disease-evd-diagnostics-using-genexpert-technology-at-a-mobile-laboratory-in-liberia-impact-on-outbreak-response-case-management-and-laboratory-systems-strengthening
#13
Philomena Raftery, Orla Condell, Christine Wasunna, Jonathan Kpaka, Ruth Zwizwai, Mahmood Nuha, Mosoka Fallah, Maxwell Freeman, Victoria Harris, Mark Miller, April Baller, Moses Massaquoi, Victoria Katawera, John Saindon, Philip Bemah, Esther Hamblion, Evelyn Castle, Desmond Williams, Alex Gasasira, Tolbert Nyenswah
The 2014-16 Ebola Virus Disease (EVD) outbreak in West Africa highlighted the necessity for readily available, accurate and rapid diagnostics. The magnitude of the outbreak and the re-emergence of clusters of EVD cases following the declaration of interrupted transmission in Liberia, reinforced the need for sustained diagnostics to support surveillance and emergency preparedness. We describe implementation of the Xpert Ebola Assay, a rapid molecular diagnostic test run on the GeneXpert platform, at a mobile laboratory in Liberia and the subsequent impact on EVD outbreak response, case management and laboratory system strengthening...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29299592/chemoprevention-of-basal-and-squamous-cell-carcinoma-with-a-single-course-of-fluorouracil-5-cream-a-randomized-clinical-trial
#14
Martin A Weinstock, Soe Soe Thwin, Julia A Siegel, Kimberly Marcolivio, Alexander D Means, Nicholas F Leader, Fiona M Shaw, Daniel Hogan, David Eilers, Susan M Swetter, Suephy C Chen, Sharon E Jacob, Erin M Warshaw, George P Stricklin, Robert P Dellavalle, Navjeet Sidhu-Malik, Nellie Konnikov, Victoria P Werth, Jonette E Keri, Leslie Robinson-Bostom, Robert J Ringer, Robert A Lew, Ryan Ferguson, John J DiGiovanna, Grant D Huang
Importance: Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States. Objective: To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma. Design, Setting, and Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized, double-blind, placebo-controlled trial of topical fluorouracil for chemoprevention of keratinocyte carcinoma...
January 3, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29297443/screening-for-active-tuberculosis-before-isoniazid-preventive-therapy-among-hiv-infected-west-african-adults
#15
R Moh, A Badjé, J-B N'takpé, G M Kouamé, D Gabillard, T Ouassa, E Ouattara, J Le Carrou, F Bohoussou, E Messou, S Eholié, X Anglaret, C Danel
SETTING: TEMPRANO was a multicentre, open-label trial in which human immunodeficiency virus (HIV) infected adults with high CD4 counts were randomised into early or deferred antiretroviral therapy (ART) arms with or without 6-month isoniazid preventive therapy (IPT) in a setting where the World Health Organization (WHO) recommends IPT in HIV-infected patients. Despite the WHO recommendation, IPT coverage remains low due to fear of the presence of undiagnosed active TB before prescribing IPT, and the related risk of drug resistance...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29296502/automated-multimodal-spectral-histopathology-for-quantitative-diagnosis-of-residual-tumour-during-basal-cell-carcinoma-surgery
#16
Radu Boitor, Kenny Kong, Dustin Shipp, Sandeep Varma, Alexey Koloydenko, Kusum Kulkarni, Somaia Elsheikh, Tom Bakker Schut, Peter Caspers, Gerwin Puppels, Martin van der Wolf, Elena Sokolova, T E C Nijsten, Brogan Salence, Hywel Williams, Ioan Notingher
Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgically-resected skin tissue. Here we report the development of a fully-automated prototype instrument based on MSH designed to be used in the clinic and operated by a non-specialist spectroscopy user. The algorithms for the AF image processing and Raman spectroscopy classification had been first optimised on a manually-operated laboratory instrument and then validated on the automated prototype using skin samples from independent patients...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29288832/new-combination-strategy-of-photodynamic-therapy-and-surgery-in-treating-recurrent-basal-cell-carcinoma-a-case-report
#17
Zhang Shu, Yang Lifeng, Yu Ruichao
BACKGROUND: There are several options for BCC treatment. But sometimes, even Mohs surgery isn't desirable because of predicted aggressive surgery. Treatment of recurrent basal cell carcinoma can be a challenge for dermatologists. METHODS: We describe a case of a man with an invasive recurrent basal cell carcinoma on his face. The tumor was difficult to be removed completely by excision. Thus one-time photodynamic therapy was performed in the defect during surgery...
December 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29288096/comorbidity-scores-associated-with-limited-life-expectancy-in-the-very-elderly-with-nonmelanoma-skin-cancer
#18
Emma M Rogers, Karen L Connolly, Kishwer S Nehal, Stephen W Dusza, Anthony M Rossi, Erica Lee
BACKGROUND: There is controversy regarding nonmelanoma skin cancer (NMSC) treatment in the very elderly, with some suggesting that this population may not live long enough to benefit from invasive treatments. Tools to assess limited life expectancy (LLE) exist, but performance in the very elderly NMSC population has not been well-defined. OBJECTIVE: Define comorbidity scores associated with LLE in the very elderly presenting for management of NMSC. METHODS: A retrospective review of 488 patients aged 85 or older presenting for NMSC management between July 1999 through December 2014 was performed...
December 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29285957/human-disease-glycomics-technology-advances-enabling-protein-glycosylation-analysis-part-1
#19
Arun V Everest-Dass, Edward S X Moh, Christopher Ashwood, Abdulrahman M M Shathili, Nicolle H Packer
Protein glycosylation is recognized as an important post-translational modification, with specific substructures having significant effects on protein folding, conformation, distribution, stability and activity. However, due to the structural complexity of glycans, elucidating glycan structure-function relationships is demanding. The fine detail of glycan structures attached to proteins (including sequence, branching, linkage and anomericity) is still best analysed after the glycans are released from the purified or mixture of glycoproteins (glycomics)...
December 29, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29285575/alteration-of-gray-matter-texture-features-over-the-whole-brain-in-medication-overuse-headache-using-a-3-dimentional-texture-analysis
#20
Zhiye Chen, Xiaoyan Chen, Zhiqiang Chen, Mengqi Liu, Huiguang He, Lin Ma, Shengyuan Yu
BACKGROUND: Imaging studies have provided valuable information in understanding the headache neuromechanism for medication-overuse headache (MOH), and the aim of this study is to investigate altered texture features of MR structural images over the whole brain in MOH using a 3-dimentional texture analysis. METHODS: Brain three-dimensional T1-weighted structural images were obtained from 44 MOH patients and 32 normal controls (NC). The imaging processing included two steps: gray matter (gray images) segment and a 3-dimensional texture features mapping...
November 28, 2017: Journal of Headache and Pain
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