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https://www.readbyqxmd.com/read/27784866/a-rapid-dialysis-method-for-analysis-of-stevioside-and-rebaudioside-a-in-foods
#1
Sumiyo Yamamoto, Shoichi Tahara, Mikio Sugiki, Hiroyuki Miyakawa, Yoko Uematsu, Yukiko Yamajima, Narue Sakamaki, Kimio Monma
A rapid dialysis method for the analysis of stevioside (SS) and rebaudioside A (RS) in foods was developed. Minced samples (10 g) were packed into 30 cm net length dialysis tubing with 30% methanol to increase the dialysis efficiency. The dialysis tubing was put in a 100 mL centrifuge tube, and the total fluid volume was made up to 100 mL with 30% methanol. Dialysis was done with shaking while heating at 50℃. The dialysis times were reduced from 48-72 hr in the conventional method to 2 hr under these conditions...
2016: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/27784241/a-review-on-the-pharmacology-and-toxicology-of-steviol-glycosides-extracted-from-stevia-rebaudiana
#2
Amir Abbas Momtazi-Borojeni, Seyed-Alireza Esmaeili, Elham Abdollahi, Amirhossein Sahebkar
Stevia rebaudiana Bertoni is a sweet and nutrient-rich plant belonging to the Asteraceae family. Stevia leaves contain steviol glycosides including stevioside, rebaudioside (A to F), steviolbioside, and isosteviol, which are responsible for the plant's sweet taste, and have commercial value all over the world as a sugar substitute in foods, beverages and medicines. Among the various steviol glycosides, stevioside, rebaudioside A and rebaudioside C are the major metabolites and these compounds are on average 250-300 times sweeter than sucrose...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27776614/stevia-preferences-in-wistar-rats
#3
Paula Núñez Martínez, Juan Argüelles Luis, Carmen Perillán Méndez
BACKGROUND: The Stevia rebaudiana plant is likely to become a major source of high-potency sweetener for the growing natural-food market. S. rebaudiana is the source of a number of sweet diterpenoid glycosides, but the major sweet constituents are rebaudioside A and stevioside. These two constituents have similar pharmacokinetic and metabolic profiles in rats and humans, and thus, studies carried out with either steviol glycoside are relevant to both. Other studies illustrate the diversity of voluntary sweet intake in mammals...
November 2016: Psicothema
https://www.readbyqxmd.com/read/27765216/the-use-of-capillary-electrophoresis-with-contactless-conductivity-detection-for-sensitive-determination-of-stevioside-and-rebaudioside-a-in-foods-and-beverages
#4
Václav Pavlíček, Petr Tůma
Two electrophoretic methods with contactless conductivity detection have been developed for determination of the content of rebaudioside A and stevioside in samples of sweeteners and beverages prepared from extracts of the plant Stevia rebaudiana Bertoni. The total content of rebaudioside A and stevioside can be determined in a fused silica capillary with an inner diameter of 10μm and total length of 31.5cm in optimised background electrolyte with the composition 170mM H3BO3/LiOH (pH 9.0). The combined peak of the two glucosides is characterised by a migration time of 54s, which completely separates it from EOF...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27649486/comparison-of-reduced-sugar-high-quality-chocolates-sweetened-with-stevioside-and-crude-stevia-green-extract
#5
Luisa Torri, Alessandra Frati, Paolino Ninfali, Stefano Mantegna, Giancarlo Cravotto, Gabriella Morini
BACKGROUND: The demand for zero and reduced-sugar food products containing cocoa is expanding continuously. The study has been designed to evaluate the feasibility of producing high-quality chocolate sweetened with a crude extract of Stevia rebaudiana (Bertoni) prepared by a green microwave-assisted water-steam extraction procedure. Seven approximately isosweet chocolate formulations were developed mixing cocoa paste, sucrose, commercial stevioside, crude green extract and maltitol in different proportions...
September 20, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27642557/gene-transcription-and-steviol-glycoside-accumulation-in-stevia-rebaudiana-under-polyethylene-glycol-induced-drought-stress-in-greenhouse-cultivation
#6
Shokoofeh Hajihashemi, Jan M C Geuns
Stevia rebaudiana is a sweet herb of the Astraceae family, which is cultivated for the natural sweeteners it contains. The aim of this study was to assess the effect of drought, simulated by the application of polyethylene glycol (5%, 10%, and 15% w/v), on the content of steviol glycosides (SVglys) and transcription levels of six genes involved in the biosynthesis of these natural sweeteners. The transcription levels of ent-kaurene synthase, ent-kaurene oxidase, ent-kaurenoic acid hydroxylase, and three UDP-dependent glycosyltransferases, UGT85C2,UGT74G1 and UGT76G1 were downregulated under polyethylene glycol treatment...
September 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27640213/docking-and-molecular-dynamics-of-steviol-glycoside-human-bitter-receptor-interactions
#7
Waldo Acevedo, Fernando González-Nilo, Eduardo Agosin
Stevia is one of the sweeteners with the greatest consumer demand because of its natural origin and minimal calorie content. Steviol glycosides (SG) are the main active compounds present in the leaves of Stevia rebaudiana and are responsible for its sweetness. However, recent in vitro studies in HEK 293 cells revealed that SG specifically activate the hT2R4 and hT2R14 bitter taste receptors, triggering this mouth feel. The objective of this study was to characterize the interaction of SG with these two receptors at the molecular level...
October 12, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27594889/corrigendum-to-stevioside-from-stevia-rebaudiana-bertoni-increases-insulin-sensitivity-in-3t3-l1-adipocytes
#8
Nabilatul Hani Mohd-Radzman, Wan Iryani Wan Ismail, Siti Safura Jaapar, Zainah Adam, Aishah Adam
[This corrects the article DOI: 10.1155/2013/938081.].
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27513814/evaluation-of-the-antihyperglycemic-effect-of-minor-steviol-glycosides-in-normoglycemic-and-induced-diabetic-wistar-rats
#9
Irma Aranda-González, Yolanda Moguel-Ordóñez, Luis Chel-Guerrero, Maira Segura-Campos, David Betancur-Ancona
Steviol glycosides are a family of compounds found in Stevia rebaudiana Bertoni that are responsible for sweetness capacity. The antihyperglycemic effect of the two major steviol glycosides, Rebaudioside A and Stevioside, has been studied and it has been found that despite having the same common structure, only Stevioside exerts an antihyperglycemic effect. Although other steviol derivatives are found in smaller amounts (minor steviol glycosides) in S. rebaudiana, whether or not they possess antihyperglycemic activity has not been evaluated...
September 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27507487/facile-preparation-of-water-soluble-curcuminoids-extracted-from-turmeric-curcuma-longa-l-powder-by-using-steviol-glucosides
#10
Thi Thanh Hanh Nguyen, Jinbeom Si, Choongil Kang, Byoungsang Chung, Donghwa Chung, Doman Kim
Curcuminoids from rhizomes of Curcuma longa possess various biological activities. However, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. In this study, curcuminoids extracted from turmeric powder using stevioside (Ste), rebaudioside A (RebA), or steviol glucosides (SG) were solubilized in water. The optimum extraction condition by Ste, RebA, or SG resulted in 11.3, 9.7, or 6.7mg/ml water soluble curcuminoids. Curcuminoids solubilized in water showed 80% stability at pH from 6...
January 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27283670/synthesis-and-characterization-of-glucosyl-stevioside-using-leuconostoc-dextransucrase
#11
Jin-A Ko, Seung-Hee Nam, Ji-Young Park, YongJung Wee, Doman Kim, Woo Song Lee, Young Bae Ryu, Young-Min Kim
Glucosyl stevioside was synthesized via transglucosylation by dextransucrase from Leuconostoc citreum KM20 (LcDexT), forming α-d-glucosyl stevioside. A production yield of 94% was reached after 5days of LcDexT reaction at 30°C. Glucosyl stevioside induced a 2-fold improved quality of taste and sweetness, compared to stevioside. After 15days of storage at 25°C, 98% of glucosyl stevioside in an aqueous solution was present in a soluble form, compared to only 11% for stevioside or rebaudioside A. Furthermore, glucosyl stevioside exhibited a similar or improved stability in commercially available soft drinks, when compared to stevioside and rebaudioside A...
November 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27252356/purification-and-preparation-of-rebaudioside-a-from-steviol-glycosides-using-one-dimensional-hydrophilic-interaction-chromatography
#12
Bin Chen, Rong Li, Xiaohui Chen, Sai Yang, Shuguang Li, Kaidi Yang, Guoliang Chen, Xiaoxun Ma
A method for purifying and preparing rebaudioside A (RA) from steviol glycosides at preparative scale was developed with resin based on hydrophilic interaction liquid chromatography (HILIC). In pure water and acetone-water system, the adsorption capacity and selectivity of five anion resins for RA, rebaudioside C (RC) and stevioside (ST) were examined and discussed. Strongly basic IRA458 with the quaternary amine group was chosen as the resin used for separating and preparing RA. The hydroxide form of IRA458 (IRA458-OH) showed the best results in terms of the adsorption behaviors for RA, RC and ST...
September 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27246994/effect-of-zinc-oxide-zno-nanoparticles-on-physiology-and-steviol-glycosides-production-in-micropropagated-shoots-of-stevia-rebaudiana-bertoni
#13
Rabia Javed, Muhammad Usman, Buhara Yücesan, Muhammad Zia, Ekrem Gürel
This study aims to address the effects of different concentrations (0, 0.1, 1.0, 10, 100 or 1000 mg L(-1)) of engineered zinc oxide (ZnO) nanoparticles (34 nm in size) on growth parameters, steviol glycosides (rebaudioside A and stevioside) production and antioxidant activities in the tissue culture grown shoots of Stevia rebaudiana Bertoni. The highest percentage of shoot formation (89.6%) at 1 mg L(-1) of ZnO nanoparticles concentration suggests a positive influence of ZnO nanoparticles on S. rebaudiana growth as compared to other treatments with or without ZnO nanoparticles...
May 24, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27229155/the-effect-of-stevia-on-the-chicken-embryo-heart
#14
Parisa Sadighara, Isa Mohammadpour, Mahdi Jahanbakhsh, Atefeh Araghi, Ahmad Nazaktabar
BACKGROUND: Stevioside is one of the most important food additives that has become well known for its sweetness. The aim of this study was to evaluate the impact of Stevioside on the heart. METHODS: 4-day-old embryonated chickens eggs were inoculated with Stevioside and kept until hatching.Shortly after, the heart tissue samples were taken to examine organ Oxidative stresses by measuring Malondialdehyde (MDA) and glutathione (GSH) levels, ferric reducing /antioxidant power (FRAP) and cupric ion reducing assay (CUPRIC)...
May 27, 2016: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/27181453/chemical-specific-adjustment-factors-inter-species-toxicokinetics-to-establish-the-adi-for-steviol-glycosides
#15
Ashley Roberts, Barry Lynch, Rebecca Rogerson, Andrew Renwick, Hua Kern, Matthew Coffee, Nicole Cuellar-Kingston, Alex Eapen, Christine Crincoli, George Pugh, Sachin Bhusari, Sidd Purkayastha, Michael Carakostas
The acceptable daily intake (ADI) of commercially available steviol glycosides is currently 0-4 mg/kg body weight (bw)/day, based on application of a 100-fold uncertainty factor to a no-observed-adverse-effect-level value from a chronic rat study. Within the 100-fold uncertainty factor is a 10-fold uncertainty factor to account for inter-species differences in toxicokinetics (4-fold) and toxicodynamics (2.5-fold). Single dose pharmacokinetics of stevioside were studied in rats (40 and 1000 mg/kg bw) and in male human subjects (40 mg/kg bw) to generate a chemical-specific, inter-species toxicokinetic adjustment factor...
May 13, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27071804/stevia-rebaudiana-ethanolic-extract-exerts-better-antioxidant-properties-and-antiproliferative-effects-in-tumour-cells-than-its-diterpene-glycoside-stevioside
#16
Víctor López, Sergio Pérez, Arturo Vinuesa, Christian Zorzetto, Olga Abian
Steviol glycosides are currently being used as natural sweeteners by the food industry and Stevia rebaudiana has long been used as a sweet plant in South America for patients suffering from diabetes. In this study, a Stevia rebaudiana ethanolic extract (SREE) was prepared, analysed and tested for antioxidant activity in terms of free radical scavenging properties and antiproliferative effects in cervix (HeLa), pancreatic (MiaPaCa-2) and colonic (HCT116) cancer cells. The antiproliferative mechanism was confirmed by testing the effects on cyclin D1-CDK4...
April 2016: Food & Function
https://www.readbyqxmd.com/read/26976334/synthesis-of-rebaudioside-a-from-stevioside-and-their-interaction-model-with-htas2r4-bitter-taste-receptor
#17
Ramit Singla, Vikas Jaitak
Steviol glycosides (SG's) from Stevia rebaudiana (Bertoni) have been used as a natural low-calorie sweeteners. Its aftertaste bitterness restricts its use for human consumption and limits its application in food and pharmaceutical products. In present study, we have performed computational analysis in order to investigate the interaction of two major constituents of SG's against homology model of the hTAS2R4 receptor. Molecular simulation study was performed using stevioside and rebaudioside A revealed that, sugar moiety at the C-3'' position in rebaudioside A causes restriction of its entry into the receptor site thereby unable to trigger the bitter reception signaling cascade...
May 2016: Phytochemistry
https://www.readbyqxmd.com/read/26965840/in-vitro-bioassay-investigations-of-the-endocrine-disrupting-potential-of-steviol-glycosides-and-their-metabolite-steviol-components-of-the-natural-sweetener-stevia
#18
Maeve Shannon, Anders Rehfeld, Caroline Frizzell, Christina Livingstone, Caoimhe McGonagle, Niels E Skakkebaek, Ewa Wielogórska, Lisa Connolly
The food industry is moving towards the use of natural sweeteners such as those produced by Stevia rebaudiana due to the number of health and safety concerns surrounding artificial sweeteners. Despite the fact that these sweeteners are natural; they cannot be assumed safe. Steviol glycosides have a steroidal structure and therefore may have the potential to act as an endocrine disruptor in the body. Reporter gene assays (RGAs), H295R steroidogenesis assay and Ca(2+) fluorimetry based assays using human sperm cells have been used to assess the endocrine disrupting potential of two steviol glycosides: stevioside and rebaudioside A, and their metabolite steviol...
May 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26949448/isosteviol-sensitizes-sarckatp-channels-towards-pinacidil-and-potentiates-mitochondrial-uncoupling-of-diazoxide-in-guinea-pig-ventricular-myocytes
#19
Zhuo Fan, Ting Wen, Yaoxu Chen, Lijie Huang, Wei Lin, Chunxia Yin, Wen Tan
KATP channel is an important mediator or factor in physiological and pathological metabolic pathway. Activation of KATP channel has been identified to be a critical step in the cardioprotective mechanism against IR injury. On the other hand, desensitization of the channel to its opener or the metabolic ligand ATP in pathological conditions, like cardiac hypertrophy, would decrease the adaption of myocardium to metabolic stress and is a disadvantage for drug therapy. Isosteviol, obtained by acid hydrolysis of stevioside, has been demonstrated to play a cardioprotective role against diseases of cardiovascular system, like anti-IR injury, antihypertension, antihyperglycemia, and so forth...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26830573/synthesis-of-rebaudioside-a-by-enzymatic-transglycosylation-of-stevioside-present-in-the-leaves-of-stevia-rebaudiana-bertoni
#20
Bhaskar Rao Adari, Sateesh Alavala, Sara A George, Harshadas M Meshram, Ashok K Tiwari, Akella V S Sarma
Rebaudioside-A is the second most abundant sweet diterpene glycoside (1-3%) present in the leaves of Stevia rebaudiana Bertoni, and is now being considered as a possible sucrose substitute due to its pleasant organoleptic properties and associated health benefits. In the present study, a novel in situ enzymatic transglycosylation of stevioside has been developed by pre-treating the stevia leaves with cellulase and adding soluble starch as the glucosyl donor. The results confirm that the transglycosylation of stevioside led to an enrichment in the rebaudioside-A content from 4% to 66%...
June 1, 2016: Food Chemistry
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