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https://www.readbyqxmd.com/read/28454400/stevioside-induced-cytotoxicity-in-colon-cancer-cells-via-reactive-oxygen-species-and-mitogen-activated-protein-kinase-signaling-pathways-mediated-apoptosis
#1
Hai-Peng Ren, Xiao-Yan Yin, Hai-Ying Yu, Hai-Feng Xiao
The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK signaling pathways in HT-29 cells was explored. Stevioside was observed to significantly inhibit cancer cell growth at a dose of 5 µM at 48 and 72 h. A dose-dependent increase in the apoptosis rate was observed with cell cycle arrest at G2/M phase...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28441725/sweet-taste-receptor-activation-in-the-gut-is-of-limited-importance-for-glucose-stimulated-glp-1-and-gip-secretion
#2
Monika Y Saltiel, Rune E Kuhre, Charlotte B Christiansen, Rasmus Eliasen, Kilian W Conde-Frieboes, Mette M Rosenkilde, Jens J Holst
Glucose stimulates the secretion of the incretin hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). It is debated whether the sweet taste receptor (STR) triggers this secretion. We investigated the role of STR activation for glucose-stimulated incretin secretion from an isolated perfused rat small intestine and whether selective STR activation by artificial sweeteners stimulates secretion. Intra-luminal administration of the STR agonists, acesulfame K (3.85% w/v), but not sucralose (1...
April 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28428073/isosteviol-prevents-the-prolongation-of-action-potential-in-hypertrophied-cardiomyoctyes-by-regulating-transient-outward-potassium-and-l-type-calcium-channels
#3
Zhuo Fan, Nanying Lv, Xiao Luo, Wen Tan
Cardiac hypertrophy is a thickening of the heart muscle that is associated with cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as an adaptive process against increased workloads and often leads to sudden arrhythmic deaths. Studies suggest that the lethal arrhythmia is attributed to hypertrophy-induced destabilization of cardiac electrical activity, especially the prolongation of the action potential. The reduced activity of Ito is demonstrated to be responsible for the ionic mechanism of prolonged action potential duration and arrhythmogeneity...
April 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28372164/optimization-of-microwave-assisted-extraction-of-total-extract-stevioside-and-rebaudioside-a-from-stevia-rebaudiana-bertoni-leaves-using-response-surface-methodology-rsm-and-artificial-neural-network-ann-modelling
#4
Kashif Ameer, Seong-Woo Bae, Yunhee Jo, Hyun-Gyu Lee, Asif Ameer, Joong-Ho Kwon
Stevia rebaudiana (Bertoni) consists of stevioside and rebaudioside-A (Reb-A). We compared response surface methodology (RSM) and artificial neural network (ANN) modelling for their estimation and predictive capabilities in building effective models with maximum responses. A 5-level 3-factor central composite design was used to optimize microwave-assisted extraction (MAE) to obtain maximum yield of target responses as a function of extraction time (X1: 1-5min), ethanol concentration, (X2: 0-100%) and microwave power (X3: 40-200W)...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28366770/a-bio-cultural-approach-to-the-study-of-food-choice-the-contribution-of-taste-genetics-population-and-culture
#5
Davide S Risso, Cristina Giuliani, Marco Antinucci, Gabriella Morini, Paolo Garagnani, Sergio Tofanelli, Donata Luiselli
The study of food choice, one of the most complex human traits, requires an integrated approach that takes into account environmental, socio-cultural and biological diversity. We recruited 183 volunteers from four geo-linguistic groups and highly diversified in terms of both genetic background and food habits from whom we collected genotypes and phenotypes tightly linked to taste perception. We confirmed previous genetic associations, in particular with stevioside perception, and noted significant differences in food consumption: in particular, broccoli, mustard and beer consumption scores were significantly higher (Adjusted P = 0...
March 31, 2017: Appetite
https://www.readbyqxmd.com/read/28363166/insight-into-anti-diabetic-effect-of-low-dose-of-stevioside
#6
Vladimirka Ilić, Saša Vukmirović, Nebojša Stilinović, Ivan Čapo, Milan Arsenović, Boris Milijašević
Diabetes mellitus is a chronic disease characterized by abnormal carbohydrate, lipid and protein metabolism due to a lack of insulin or reduced target cell sensitivity to insulin. Stevia rebaudiana is an important source of biochemically active substances with proven anti-diabetic effect. The aim of this study was to determine anti-diabetic effects of the low dose of stevioside in NMRI Haan mice. Aqueous stevioside solution (20mg/kg body weight) was administered by oral route of administration. Anti-diabetic effect of stevioside was estimated by oral glucose tolerance test, adrenaline test after a 10day stevioside treatment, and alloxan induced hyperglycaemia in mice (two experimental groups, 10day stevioside treatment before and after alloxan administration)...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28361903/steviol-glycosides-enhance-pancreatic-beta-cell-function-and-taste-sensation-by-potentiation-of-trpm5-channel-activity
#7
Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets, Rudi Vennekens
Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca(2+)-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner...
March 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28348965/in-vitro-and-in-vivo-assessment-of-inhibitory-effect-of-stevioside-on-pro-inflammatory-cytokines
#8
Jatuporn Noosud, Narissara Lailerd, Autchara Kayan, Chaiwat Boonkaewwan
OBJECTIVE: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity. The aim of the present study was to examine in vitro and in vivo effects of stevioside on rats plasma levels of tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (PBMCs). MATERIALS AND METHODS: Male wistar rats weighing between 170-220 g were given stevioside (0, 500 and 1000 mg/kg BW/day) for 6 weeks...
March 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28343388/development-and-validation-of-an-enzymatic-method-to-determine-stevioside-content-from-stevia-rebaudiana
#9
Somsiri Udompaisarn, Dumrongkiet Arthan, Jamorn Somana
An enzymatic method for specific determination of stevioside content was established. Recombinant β-glucosidase BT_3567 (rBT_3567) from Bacteroides thetaiotaomicron HB-13 exhibited selective hydrolysis of stevioside at β-1,2-glycosidic bond to yield rubusoside and glucose. Coupling of this enzyme with glucose oxidase and peroxidase allowed for quantitation of stevioside content in Stevia samples by using a colorimetric-based approach. The series of reactions for stevioside determination can be completed within 1 h at 37 °C...
April 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28254632/metabolic-and-inflammatory-responses-to-the-common-sweetener-stevioside-and-a-glycemic-challenge-in-horses-with-equine-metabolic-syndrome
#10
S E Elzinga, B Rohleder, B Schanbacher, K McQuerry, V D Barker, A A Adams
Extracts derived from the leaves of the stevia plant (stevioside) are commonly used as sweeteners for humans and horses. Stevioside appears to be safe for human consumption, including for individuals with insulin dysregulation. In the horse, the safety or metabolic effects of stevioside on normal animals or on those with metabolic dysfunction are unknown. Furthermore, the inflammatory response to a glycemic challenge or to stevioside in horses is not well defined. Therefore, the objective of this study was to measure the effects of stevioside and a glycemic challenge on insulin, glucose, and inflammatory responses in horses with a common metabolic dysfunction (equine metabolic syndrome or EMS) compared with non-EMS controls...
February 4, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28242916/physico-chemical-and-sensory-characteristics-of-steviolbioside-synthesized-from-stevioside-and-its-application-in-fruit-drinks-and-food
#11
Sherine N Khattab, Mona I Massoud, Amal M Abd El-Razek, Ayman El-Faham
Steviolbioside (Sb) was synthesized from stevioside and characterized by infrared, nuclear magnetic resonance ((1)H NMR and (13)C NMR) spectroscopy. The purity melting point, solubility, acute toxicity, heat stability and sensory properties of Sb were evaluated. Physico-chemical and sensory properties of low calorie fruit drinks and shortened cake prepared by replacing sugar with Sb were evaluated. Sb was stable in neutral or acidic aqueous solutions maintained at 100 °C for 2 h. The sweetness intensity rate of Sb was found to be about 44 and 18...
January 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28108883/rapid-solid-liquid-dynamic-extraction-rslde-a-new-rapid-and-greener-method-for-extracting-two-steviol-glycosides-stevioside-and-rebaudioside-a-from-stevia-leaves
#12
Monica Gallo, Manuela Vitulano, Anna Andolfi, Marina DellaGreca, Esterina Conte, Martina Ciaravolo, Daniele Naviglio
Stevioside and rebaudioside A are the main diterpene glycosides present in the leaves of the Stevia rebaudiana plant, which is used in the production of foods and low-calorie beverages. The difficulties associated with their extraction and purification are currently a problem for the food processing industries. The objective of this study was to develop an effective and economically viable method to obtain a high-quality product while trying to overcome the disadvantages derived from the conventional transformation processes...
June 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28090275/induction-of-epigenetic-alteration-by-cpuk02-an-ent-kaurenoid-derivative-of-stevioside
#13
Pooneh Mokarram, Zeinab Mohammadi, Saeid Khazayel, Zhang Dayong
BACKGROUND: Dietary polyphenols, such as those found in green tea and red wine, are linked to antitumor activity. They are known to influence many signaling pathways epigenetically within the human body. In this regard, CPUK02 (15-Oxosteviol benzyl ester) is a new ent-kaurenoid derivative of stevioside and exhibits strong anti-cancer activity in vitro and in vivo. Nowadays, the role of epigenetics in cancer has been the subject of intensive study and DNA methylation targeting represents a relevant strategy for cancer treatment...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27979110/sweetness-prediction-of-natural-compounds
#14
Jean-Baptiste Chéron, Iuri Casciuc, Jérôme Golebiowski, Serge Antonczak, Sébastien Fiorucci
Based on the most exhaustive database of sweeteners with known sweetness values, a new quantitative structure-activity relationship model for sweetness prediction has been set up. Analysis of the physico-chemical properties of sweeteners in the database indicates that the structure of most potent sweeteners combines a hydrophobic scaffold functionalized by a limited number of hydrogen bond sites (less than 4 hydrogen bond donors and 10 acceptors), with a moderate molecular weight ranging from 350 to 450g·mol(-1)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27923373/microbial-production-of-next-generation-stevia-sweeteners
#15
Kim Olsson, Simon Carlsen, Angelika Semmler, Ernesto Simón, Michael Dalgaard Mikkelsen, Birger Lindberg Møller
BACKGROUND: The glucosyltransferase UGT76G1 from Stevia rebaudiana is a chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia sweeteners, rebaudioside D (Reb D) and rebaudioside M (Reb M). These steviol glucosides carry five and six glucose units, respectively, and have low sweetness thresholds, high maximum sweet intensities and exhibit a greatly reduced lingering bitter taste compared to stevioside and rebaudioside A, the most abundant steviol glucosides in the leaves of Stevia rebaudiana...
December 7, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27784866/a-rapid-dialysis-method-for-analysis-of-stevioside-and-rebaudioside-a-in-foods
#16
Sumiyo Yamamoto, Shoichi Tahara, Mikio Sugiki, Hiroyuki Miyakawa, Yoko Uematsu, Yukiko Yamajima, Narue Sakamaki, Kimio Monma
A rapid dialysis method for the analysis of stevioside (SS) and rebaudioside A (RS) in foods was developed. Minced samples (10 g) were packed into 30 cm net length dialysis tubing with 30% methanol to increase the dialysis efficiency. The dialysis tubing was put in a 100 mL centrifuge tube, and the total fluid volume was made up to 100 mL with 30% methanol. Dialysis was done with shaking while heating at 50℃. The dialysis times were reduced from 48-72 hr in the conventional method to 2 hr under these conditions...
2016: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/27784241/a-review-on-the-pharmacology-and-toxicology-of-steviol-glycosides-extracted-from-stevia-rebaudiana
#17
Amir Abbas Momtazi-Borojeni, Seyed-Alireza Esmaeili, Elham Abdollahi, Amirhossein Sahebkar
Stevia rebaudiana Bertoni is a sweet and nutrient-rich plant belonging to the Asteraceae family. Stevia leaves contain steviol glycosides including stevioside, rebaudioside (A to F), steviolbioside, and isosteviol, which are responsible for the plant's sweet taste, and have commercial value all over the world as a sugar substitute in foods, beverages and medicines. Among the various steviol glycosides, stevioside, rebaudioside A and rebaudioside C are the major metabolites and these compounds are on average 250-300 times sweeter than sucrose...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27776614/stevia-preferences-in-wistar-rats
#18
Paula Núñez Martínez, Juan Argüelles Luis, Carmen Perillán Méndez
BACKGROUND: The Stevia rebaudiana plant is likely to become a major source of high-potency sweetener for the growing natural-food market. S. rebaudiana is the source of a number of sweet diterpenoid glycosides, but the major sweet constituents are rebaudioside A and stevioside. These two constituents have similar pharmacokinetic and metabolic profiles in rats and humans, and thus, studies carried out with either steviol glycoside are relevant to both. Other studies illustrate the diversity of voluntary sweet intake in mammals...
November 2016: Psicothema
https://www.readbyqxmd.com/read/27765216/the-use-of-capillary-electrophoresis-with-contactless-conductivity-detection-for-sensitive-determination-of-stevioside-and-rebaudioside-a-in-foods-and-beverages
#19
Václav Pavlíček, Petr Tůma
Two electrophoretic methods with contactless conductivity detection have been developed for determination of the content of rebaudioside A and stevioside in samples of sweeteners and beverages prepared from extracts of the plant Stevia rebaudiana Bertoni. The total content of rebaudioside A and stevioside can be determined in a fused silica capillary with an inner diameter of 10μm and total length of 31.5cm in optimised background electrolyte with the composition 170mM H3BO3/LiOH (pH 9.0). The combined peak of the two glucosides is characterised by a migration time of 54s, which completely separates it from EOF...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27649486/comparison-of-reduced-sugar-high-quality-chocolates-sweetened-with-stevioside-and-crude-stevia-green-extract
#20
Luisa Torri, Alessandra Frati, Paolino Ninfali, Stefano Mantegna, Giancarlo Cravotto, Gabriella Morini
BACKGROUND: The demand for zero and reduced-sugar food products containing cocoa is expanding continuously. The present study was designed to evaluate the feasibility of producing high-quality chocolate sweetened with a crude extract of Stevia rebaudiana (Bertoni) prepared by a green microwave-assisted water-steam extraction procedure. Seven approximately isosweet chocolate formulations were developed, mixing cocoa paste, sucrose, commercial stevioside, crude green extract and maltitol in different proportions...
September 20, 2016: Journal of the Science of Food and Agriculture
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