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Garcinia mangostana

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https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#1
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
October 13, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27714857/depigmentation-of-%C3%AE-melanocyte-stimulating-hormone-treated-melanoma-cells-by-%C3%AE-mangostin-is-mediated-by-selective-autophagy
#2
Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim
Melanogenesis is a key pathway for the regulation of skin pigmentation and the development of skin-lightening/whitening drugs or cosmetics. In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model. β-Mangostin significantly inhibited the protein level of tyrosinase induced by α-MSH in UPS (ubiquitin proteasome system)-independent and lysosome-dependent manner...
October 7, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27668185/de-novo-transcriptome-assembly-of-mangosteen-garcinia-mangostana-l-fruit
#3
Deden Derajat Matra, Toshinori Kozaki, Kazuo Ishii, Roedhy Poerwanto, Eiichi Inoue
Garcinia mangostana L. (Mangosteen), of the family Clusiaceae, is one of the economically important tropical fruits in Indonesia. In the present study, we performed de novo transcriptomic analysis of Garcinia mangostana L. through RNA-Seq technology. We obtained the raw data from 12 libraries through Ion Proton System. Clean reads of 191,735,809 were obtained from 307,634,890 raw reads. The raw data obtained in this study can be accessible in DDBJ database with accession number of DRA005014 with bioproject accession number of PRJDB5091...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27618982/phenolics-from-garcinia-mangostana-alleviate-exaggerated-vasoconstriction-in-metabolic-syndrome-through-direct-vasodilatation-and-nitric-oxide-generation
#4
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
BACKGROUND: Exaggerated vasoconstriction plays a very important role in the hypertension, a major component of metabolic syndrome (MetS). In the current work, the potential protective effect of methanol extract of fruit hulls of Garcinia mangostana L. on the exaggerated vasoconstriction in MetS has been investigated. In addition, the bioactive fraction and compounds as well as the possible mechanism of action have been illustrated. METHODS: The effect of methanol extract of G...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27617279/dataset-of-ssr-markers-for-issr-suppression-pcr-to-detect-genetic-variation-in-garcinia-mangostana-l-in-peninsular-malaysia
#5
Sri A'jilah Samsir, Hamidun Bunawan, Choong Chee Yen, Normah Mohd Noor
In this dataset, we present 15 Simple Sequence Repeat (SSR) markers with the motifs (AC)n, (GA)n, and (AC)n(AG)n using a ISSR-Suppression-PCR technique in order to discriminate Garcinia mangostana from diverse geographical origins in Peninsular Malaysia. A few loci showed differences between 3 and 6 bp in allele size, indicating that there are some polymorphisms between individuals correlating to the number of SSR repeats that may be useful for differentiate of genotypes. Collectively, these data show that the ISSR-Suppression-PCR is a valuable method to illustrate genetic variation of selected G...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27592485/antimicrobial-and-quorum-sensing-inhibitory-activities-of-the-pericarp-of-garcinia-mangostana
#6
Hani Z Asfour
A prenylated xanthone, α-mangostin was separated from the alcoholic extract of Garcinia mangostana pericarp. Its structure was established by different spectroscopic analysis. The total methanolic extract (TME) and different fractions of G. mangostana pericarp as well as α-mangostin were assessed for their antimicrobial and quorum sensing inhibitory effects (QSI). The TME, CHCl3 fraction, and α-mangostin exhibited strong activity against all tested strains. While, EtOAc, n-BuOH, and aqueous fractions showed moderate activity against some of the tested organisms...
July 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27584012/%C3%AE-mangostin-extraction-from-the-native-mangosteen-garcinia-mangostana-l-and-the-binding-mechanisms-of-%C3%AE-mangostin-to-hsa-or-trf
#7
Ming Guo, Xiaomeng Wang, Xiaowang Lu, Hongzheng Wang, Peter E Brodelius
In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction method for industrial application was explored. A high yield of α-mangostin (5.2%) was obtained by extraction from dried mangosteen pericarps with subsequent purification on macroporous resin HPD-400. The chemical structure of α-mangostin was verified mass spectrometry (MS), nuclear magnetic resonance (1H NMR and 13C NMR), infrared spectroscopy (IR) and UV-Vis spectroscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27566110/synergism-and-the-mechanism-of-action-of-the-combination-of-%C3%AE-mangostin-isolated-from-garcinia-mangostana-l-and-oxacillin-against-an-oxacillin-resistant-staphylococcus-saprophyticus
#8
Sineewan Phitaktim, Mullika Chomnawang, Kittipot Sirichaiwetchakoon, Benjawan Dunkhunthod, Glyn Hobbs, Griangsak Eumkeb
BACKGROUND: Globally, staphylococci have developed resistance to many antibiotics. New approaches to chemotherapy are needed and one such approach could be to use plant derived actives with conventional antibiotics in a synergestic way. The purpose of this study was to isolate α-mangostin from the mangosteen (Garcinia mangostana L.; GML) and investigate antibacterial activity and mechanisms of action when used singly and when combined with oxacillin against oxacillin-resistant Staphylococcus saprophyticus (ORSS) strains...
2016: BMC Microbiology
https://www.readbyqxmd.com/read/27561254/nitric-oxide-inhibitory-xanthones-from-the-pericarps-of-garcinia-mangostana
#9
Qianyu Liu, Dan Li, Anqi Wang, Zhen Dong, Sheng Yin, Qingwen Zhang, Yang Ye, Liangchun Li, Ligen Lin
Mangosteen (Garcinia mangostana, Clusiaceae) is called "queen of fruit" in Southeast Asia. In the current study, three dimeric xanthones, garcinoxanthones A-C, and four monomeric xanthones, garcinoxanthones D-G, together with 18 known xanthones, were isolated from the pericarps of G. mangostana, collected in Thailand. The structures of garcinoxanthones A-G were elucidated by analysis of their 1D and 2D NMR and other spectroscopic data, and their absolute configurations were determined by the CD spectra. All seven compounds were tested for nitric oxide (NO) inhibitory activity on lipopolysaccharide (LPS)-stimulated RAW264...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27558585/efficacy-and-tolerability-of-meratrim-for-weight-management-a-randomized-double-blind-placebo-controlled-study-in-healthy-overweight-human-subjects
#10
Venkateshwarlu Kudiganti, Raveendra Ramamurthy Kodur, Sushma Raveendra Kodur, Manjunath Halemane, Dheeraj Kumar Deep
BACKGROUND: Meratrim is a blend of two plant extracts obtained from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rinds. Previous studies have demonstrated that Meratrim is effective for weight management in obese individuals. The objective of this study was to assess the efficacy and tolerability of Meratrim in managing body weight in healthy overweight subjects. METHODS: Sixty participants with a mean BMI of 28.3 kg/m(2) were randomized into two groups receiving either 400 mg of Meratrim twice daily or two identical placebo capsules for a period of 16 weeks...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27322374/bioactivity-guided-identification-of-botanical-inhibitors-of-ketohexokinase
#11
MyPhuong T Le, Miguel A Lanaspa, Christina M Cicerchi, Jatinder Rana, Jeffrey D Scholten, Brandi L Hunter, Christopher J Rivard, R Keith Randolph, Richard J Johnson
OBJECTIVE: In developed countries with westernized diets, the excessive consumption of added sugar in beverages and highly refined and processed foods is associated with increased risk for obesity, diabetes, and cardiovascular diseases. As a major constituent of added sugars, fructose has been shown to cause a variety of adverse metabolic effects, such as impaired insulin sensitivity, hypertriglyceridemia, and oxidative stress. Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive's fructose's adverse effects...
2016: PloS One
https://www.readbyqxmd.com/read/27257614/dataset-of-fourier-transform-infrared-coupled-with-chemometric-analysis-used-to-distinguish-accessions-of-garcinia-mangostana-l-in-peninsular-malaysia
#12
Sri A'jilah Samsir, Hamidun Bunawan, Choong Chee Yen, Normah Mohd Noor
In this dataset, we distinguish 15 accessions of Garcinia mangostana from Peninsular Malaysia using Fourier transform-infrared spectroscopy coupled with chemometric analysis. We found that the position and intensity of characteristic peaks at 3600-3100 cm(-) (1) in IR spectra allowed discrimination of G. mangostana from different locations. Further principal component analysis (PCA) of all the accessions suggests the two main clusters were formed: samples from Johor, Melaka, and Negeri Sembilan (South) were clustered together in one group while samples from Perak, Kedah, Penang, Selangor, Kelantan, and Terengganu (North and East Coast) were in another clustered group...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27246698/current-trends-of-tropical-fruit-waste-utilization
#13
Choon Yoong Cheok, Noranizan Mohd Adzahan, Russly Abdul Rahman, Nur Hanani Zainal Abedin, Norhayati Hussain, Rabiha Sulaiman, Gun Hean Chong
Recent rapid growth of the world's population has increased food demands. This phenomenon poses a great challenge for food manufacturers in maximizing the existing food or plant resources. Nowadays, the recovery of health benefit bioactive compounds from fruit wastes is a research trend not only to help minimize the waste burden, but also to meet the intensive demand from the public for phenolic compounds which are believed to have protective effects against chronic diseases. This review is focused on polyphenolic compounds recovery from tropical fruit wastes and its current trend of utilization...
May 31, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27208974/hypoglycaemic-activity-of-ethanolic-extract-of-garcinia-mangostana-linn-in-normoglycaemic-and-streptozotocin-induced-diabetic-rats
#14
Muhammad Taher, Tg Muhamad Faris Syafiq Tg Zakaria, Deny Susanti, Zainul Amiruddin Zakaria
BACKGROUND: Various parts of Garcinia mangostana Linn., including its pericarp, have been traditionally used to treat a variety of ailments. In an attempt to establish its medicinal value, the present study was carried out to determine the hypoglycaemic potential of G. mangostana pericarp ethanolic extract (GME) using the streptozotocin-induced (STZ) diabetic rats. METHODS: GME at 2,000 mg/kg was subjected to a single-dose acute toxicity test. Following this, the effect of GME (50, 100, and 200 mg/kg) on blood glucose level of normoglycaemic and STZ-induced diabetic rats was determined using single-dose (acute) and multiple-dose (subacute) approaches...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27185538/food-safety-in-thailand-3-pesticide-residues-detected-in-mangosteen-garcinia-mangostana-l-queen-of-fruits
#15
Kamonrat Phopin, Sompon Wanwimolruk, Virapong Prachayasittikul
BACKGROUND: For developing countries like Thailand, regulation of pesticide usage exists but is not fully enforced. Therefore, pesticide residues in vegetables and fruits have not been well monitored. This study aimed to determine the pesticide residues in mangosteen fruits sold in Thailand. The mangosteen samples (n = 111) were purchased and the content of 28 pesticides were analyzed by GC-MS/MS method. RESULTS: Of pesticides tested, 8 pesticides were found in 100% of the mangosteen samples...
May 17, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27180784/in-vivo-antibacterial-activity-of-garcinia-mangostana-pericarp-extract-against-methicillin-resistant-staphylococcus-aureus-in-a-mouse-superficial-skin-infection-model
#16
Nitima Tatiya-Aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn
CONTEXT: Garcinia mangostana Linn. (Guttiferae) (GM) pericarp has been shown to exhibit good in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA); however, there is currently no available information regarding its in vivo antibacterial activity. OBJECTIVE: To examine in vivo antibacterial activity of G. mangostana extract against MRSA. MATERIALS AND METHODS: GM pericarp was extracted by ethanol (GM-EtOH) and methanol (GM-MeOH)...
May 14, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27177723/garcinone-d-a-natural-xanthone-promotes-c17-2-neural-stem-cell-proliferation-possible-involvement-of-stat3-cyclin-d1-pathway-and-nrf2-ho-1-pathway
#17
Xiaohong Yang, Shengnan Wang, Ying Ouyang, Yaling Tu, Anmin Liu, Yinghong Tian, Mingliang He, Rongbiao Pi
Garcinia mangostana L. (Mangosteen) has been used to treat various pathological conditions, including inflammation and urinary tract infections. Here, we observed that garcinone D, a natural xanthone from mangosteen, promoted the proliferation of C17.2 neural progenitor cells and also resulted in a larger percentage of cells in S phase compared with the control group. Moreover, garcinone D increased the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and Cyclin D1 in concentration- and time- dependent manners...
July 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27152103/acute-garcinia-mangostana-mangosteen-supplementation-does-not-alleviate-physical-fatigue-during-exercise-a-randomized-double-blind-placebo-controlled-crossover-trial
#18
Chih-Wei Chang, Tzu-Zung Huang, Wen-Hsin Chang, Yi-Chun Tseng, Yu-Tse Wu, Mei-Chich Hsu
BACKGROUND: The purple mangosteen (Garcinia mangostana), known as the "queen of fruit," is widely consumed and unique not only because of its outstanding appearance and flavor but also its remarkable and diverse pharmacological effects. The aim of the present study is to evaluate the effect of acute mangosteen supplementation on physical fatigue during exercise. METHODS: A randomized, double-blind, placebo-controlled, crossover study was carried out by 12 healthy adults...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27042187/dna-protection-against-oxidative-damage-using-the-hydroalcoholic-extract-of-garcinia-mangostana-and-alpha-mangostin
#19
Ronaldo Carvalho-Silva, Alanna Cibelle Fernandes Pereira, Rúbens Prince Dos Santos Alves, Temenouga N Guecheva, João A P Henriques, Martin Brendel, Cristina Pungartnik, Fabrício Rios-Santos
Garcinia mangostana, popularly known as "mangosteen fruit," originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia. Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing. We, therefore, evaluated genotoxicity/mutagenicity of hydroethanolic mangosteen extract [HEGM, 10 to 640 μg/mL] in established test assays (Comet assay, micronucleus test, and Salmonella/microsome test)...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27038926/natural-xanthones-from-garcinia-mangostana-with-multifunctional-activities-for-the-therapy-of-alzheimer-s-disease
#20
Sheng-Nan Wang, Qian Li, Ming-Hua Jing, Espargaró Alba, Xiao-Hong Yang, Raimon Sabaté, Yi-Fan Han, Rong-Biao Pi, Wen-Jian Lan, Xiao-Bo Yang, Jing-Kao Chen
Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named α-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and γ-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced β-amyloid (Aβ) aggregation and also β-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators...
July 2016: Neurochemical Research
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