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Garcinia mangostana

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https://www.readbyqxmd.com/read/28321995/clinical-and-microbiological-efficacy-of-4-garcinia-mangostana-l-pericarp-gel-as-local-drug-delivery-in-the-treatment-of-chronic-periodontitis-a-randomized-controlled-clinical-trial
#1
Jaideep Mahendra, Little Mahendra, Priyadharshini Svedha, Sandhya Cherukuri, Georgios E Romanos
AIM: The aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (RCM), such as Treponema denticola (Td), Porphyromonas gingivalis, and Tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (Garcinia mangostana [MGA]) as an adjunct to scaling and root planing (SRP). METHODS: Twenty-five patients (MGA group) were treated with SRP, and the subgingival application of mangostana gel was used as local drug delivery...
March 20, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28284429/pharmacology-of-mangostins-and-their-derivatives-a-comprehensive-review
#2
REVIEW
Ming-Hui Wang, Kuo-Jun Zhang, Qin-Lan Gu, Xiao-Ling Bi, Jin-Xin Wang
Mangosteen (Garcinia mangostana Linn.) is a well-known tropical tree indigenous to Southeast Asia. Its fruit's pericarp abounds with a class of isoprenylated xanthones which are referred as mangostins. Numerous in vitro and in vivo studies have shown that mangostins and their derivatives possess diverse pharmacological activities, such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic activities as well as neuroprotective properties in Alzheimer's disease (AD). This review article provides a comprehensive review of the pharmacological activities of mangostins and their derivatives to reveal their promising utilities in the treatment of certain important diseases, mainly focusing on the discussions of the underlying molecular targets/pathways, modes of action, and relevant structure-activity relationships (SARs)...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28274409/unraveling-the-inhibition-mechanism-of-cyanidin-3-sophoroside-on-polyphenol-oxidase-and-its-effect-on-enzymatic-browning-of-apples
#3
Hridya Hemachandran, Amrita Anantharaman, Sankari Mohan, Gopalakrishnan Mohan, D Thirumal Kumar, Diksha Dey, Drishty Kumar, Priyanka Dey, Amrita Choudhury, C George Priya Doss, Siva Ramamoorthy
The hunt for anti-browning agents in the food and agricultural industries aims to minimize nutritional loss and prolong post harvest storage. In the present study, the effect of cyanidin-3-sophoroside (CS) from Garcinia mangostana rind, on polyphenol oxidase (PPO) activity was investigated. The non-competitive inhibition mode of CS was determined by Lineweaver Burk plot. CS forms a ground-state complex by quenching the intrinsic fluorescence of PPO. The static quenching was temperature-dependent with an activation energy of 4...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28274037/antimicrobial-effects-of-garcinia-mangostana-on-cariogenic-microorganisms
#4
Sunitha Janardhanan, Jaideep Mahendra, A S Smiline Girija, Little Mahendra, Vijayashree Priyadharsini
INTRODUCTION: Garcinia mangostana commonly called as Mangosteen fruit has been used as an antibacterial agent since age old times. The mangosteen pericarp has proven to have antibacterial effect, but the effect of the same on cariogenic organisms has not been explored. The present study was an attempt to gain a better understanding of the antibacterial effect of mangosteen pericarp on the cariogenic bacteria, to unravel the therapeutic potential for the same. AIM: The aim of the study was to assess the antibacterial efficacy of the crude chloroform extract of mangosteen pericarp against cariogenic bacteria...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28241761/antimalarial-activity-of-garcinia-mangostana-l-rind-and-its-synergistic-effect-with-artemisinin-in-vitro
#5
Susy Tjahjani
BACKGROUND: Malaria especially falciparum malaria still causes high morbidity and mortality in tropical countries. Several factors have been linked to this situation and the most important one is the rapid spread of parasite resistance to the currently available antimalarials, including artemisinin. Artemisinin is the main component of the currently recommended antimalarial, artemisinin based combination therapy (ACT), and it is a free radical generating antimalarial. Garcinia mangostana L (mangosteen) rind contain a lot of xanthone compounds acting as an antioxidant and exhibited antimalarial activity...
February 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28208680/anti-bacterial-and-anti-fungal-activity-of-xanthones-obtained-via-semi-synthetic-modification-of-%C3%AE-mangostin-from-garcinia-mangostana
#6
Srinivasan Narasimhan, Shanmugam Maheshwaran, Imad A Abu-Yousef, Amin F Majdalawieh, Janarthanam Rethavathi, Prince Edwin Das, Palmiro Poltronieri
The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity...
February 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28108382/new-xanthones-and-cytotoxic-constituents-from-garcinia-mangostana-fruit-hulls-against-human-hepatocellular-breast-and-colorectal-cancer-cell-lines
#7
Gamal A Mohamed, Ahmed M Al-Abd, Ali M El-Halawany, Hossam M Abdallah, Sabrin R M Ibrahim
ETHNOPHARMACOLOGICAL RELEVANCE: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. It is cultivated in Southeast Asian countries: Malaysia, Indonesia, Sri Lanka, Burma, Thailand, and Philippines. Traditionally, numerous parts of G. mangostana have been utilized to treat various ailments such as abdominal pain, haemorrhoids, food allergies, arthritis, leucorrhoea, gonorrhea, diarrhea, dysentery, wound infection, suppuration, and chronic ulcer...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28017996/extraction-of-anthocyanins-from-pericarp-and-lipids-from-seeds-of-mangosteen-garcinia-mangostana-l-by-ultrasound-assisted-extraction-uae-and-evaluation-of-pericarp-extract-enriched-functional-ice-cream
#8
Lawan Hiranrangsee, Kishore K Kumaree, Muhammad Bilal Sadiq, Anil K Anal
Ultrasound-assisted extraction (UAE) was used to extract the anthocyanins from pericarp and lipids from the seeds of mangosteen. The optimum time for extraction of anthocyanin by maceration method and shaking water bath was 6 and 4 h, respectively, whereas, it was 5 min only for ultrasonic assisted extraction method. The anthocyanin content, extracted by UAE, was 23.54 mg Cyn-3-Glu/100 g. The regression equation derived by response surface methodology (RSM), was used to predict the anthocyanin content extracted by using UAE...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27975991/diol-based-natural-deep-eutectic-solvent-extraction-of-%C3%AE-mangostin-from-the-pericarp-of-garcinia-mangostana
#9
K Mulia, E Krisanti, F Fauzia, S Putri
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27933873/amelioration-of-experimental-autoimmune-encephalomyelitis-by-isogarcinol-extracted-from-garcinia-mangostana-l-mangosteen
#10
Mengqi Wang, Yufei Xie, Youxiu Zhong, Juren Cen, Lei Wang, Yuanyuan Liu, Ying Zhu, Li Tong, Qun Wei
Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and its mechanism of action is still very limited. In this study, we explored the therapeutic effect of isogarcinol in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Treatment with oral 100 mg/kg isogarcinol markedly ameliorated clinical scores, alleviated inflammation and demyelination of the spinal cord, and reduced intracranial lesions in EAE mice...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#11
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
January 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27714857/depigmentation-of-%C3%AE-melanocyte-stimulating-hormone-treated-melanoma-cells-by-%C3%AE-mangostin-is-mediated-by-selective-autophagy
#12
Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim
Melanogenesis is a key pathway for the regulation of skin pigmentation and the development of skin-lightening/skin-whitening drugs or cosmetics. In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model. β-Mangostin significantly inhibited the protein level of tyrosinase induced by α-MSH in UPS (ubiquitin proteasome system)-independent and lysosome-dependent manner...
October 7, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27668185/de-novo-transcriptome-assembly-of-mangosteen-garcinia-mangostana-l-fruit
#13
Deden Derajat Matra, Toshinori Kozaki, Kazuo Ishii, Roedhy Poerwanto, Eiichi Inoue
Garcinia mangostana L. (Mangosteen), of the family Clusiaceae, is one of the economically important tropical fruits in Indonesia. In the present study, we performed de novo transcriptomic analysis of Garcinia mangostana L. through RNA-Seq technology. We obtained the raw data from 12 libraries through Ion Proton System. Clean reads of 191,735,809 were obtained from 307,634,890 raw reads. The raw data obtained in this study can be accessible in DDBJ database with accession number of DRA005014 with bioproject accession number of PRJDB5091...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27618982/phenolics-from-garcinia-mangostana-alleviate-exaggerated-vasoconstriction-in-metabolic-syndrome-through-direct-vasodilatation-and-nitric-oxide-generation
#14
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
BACKGROUND: Exaggerated vasoconstriction plays a very important role in the hypertension, a major component of metabolic syndrome (MetS). In the current work, the potential protective effect of methanol extract of fruit hulls of Garcinia mangostana L. on the exaggerated vasoconstriction in MetS has been investigated. In addition, the bioactive fraction and compounds as well as the possible mechanism of action have been illustrated. METHODS: The effect of methanol extract of G...
September 13, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27617279/dataset-of-ssr-markers-for-issr-suppression-pcr-to-detect-genetic-variation-in-garcinia-mangostana-l-in-peninsular-malaysia
#15
Sri A'jilah Samsir, Hamidun Bunawan, Choong Chee Yen, Normah Mohd Noor
In this dataset, we present 15 Simple Sequence Repeat (SSR) markers with the motifs (AC)n, (GA)n, and (AC)n(AG)n using a ISSR-Suppression-PCR technique in order to discriminate Garcinia mangostana from diverse geographical origins in Peninsular Malaysia. A few loci showed differences between 3 and 6 bp in allele size, indicating that there are some polymorphisms between individuals correlating to the number of SSR repeats that may be useful for differentiate of genotypes. Collectively, these data show that the ISSR-Suppression-PCR is a valuable method to illustrate genetic variation of selected G...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27592485/antimicrobial-and-quorum-sensing-inhibitory-activities-of-the-pericarp-of-garcinia-mangostana
#16
Hani Z Asfour
A prenylated xanthone, α-mangostin was separated from the alcoholic extract of Garcinia mangostana pericarp. Its structure was established by different spectroscopic analysis. The total methanolic extract (TME) and different fractions of G. mangostana pericarp as well as α-mangostin were assessed for their antimicrobial and quorum sensing inhibitory effects (QSI). The TME, CHCl3 fraction, and α-mangostin exhibited strong activity against all tested strains. While, EtOAc, n-BuOH, and aqueous fractions showed moderate activity against some of the tested organisms...
July 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27584012/%C3%AE-mangostin-extraction-from-the-native-mangosteen-garcinia-mangostana-l-and-the-binding-mechanisms-of-%C3%AE-mangostin-to-hsa-or-trf
#17
Ming Guo, Xiaomeng Wang, Xiaowang Lu, Hongzheng Wang, Peter E Brodelius
In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction method for industrial application was explored. A high yield of α-mangostin (5.2%) was obtained by extraction from dried mangosteen pericarps with subsequent purification on macroporous resin HPD-400. The chemical structure of α-mangostin was verified mass spectrometry (MS), nuclear magnetic resonance (1H NMR and 13C NMR), infrared spectroscopy (IR) and UV-Vis spectroscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27566110/synergism-and-the-mechanism-of-action-of-the-combination-of-%C3%AE-mangostin-isolated-from-garcinia-mangostana-l-and-oxacillin-against-an-oxacillin-resistant-staphylococcus-saprophyticus
#18
Sineewan Phitaktim, Mullika Chomnawang, Kittipot Sirichaiwetchakoon, Benjawan Dunkhunthod, Glyn Hobbs, Griangsak Eumkeb
BACKGROUND: Globally, staphylococci have developed resistance to many antibiotics. New approaches to chemotherapy are needed and one such approach could be to use plant derived actives with conventional antibiotics in a synergestic way. The purpose of this study was to isolate α-mangostin from the mangosteen (Garcinia mangostana L.; GML) and investigate antibacterial activity and mechanisms of action when used singly and when combined with oxacillin against oxacillin-resistant Staphylococcus saprophyticus (ORSS) strains...
2016: BMC Microbiology
https://www.readbyqxmd.com/read/27561254/nitric-oxide-inhibitory-xanthones-from-the-pericarps-of-garcinia-mangostana
#19
Qianyu Liu, Dan Li, Anqi Wang, Zhen Dong, Sheng Yin, Qingwen Zhang, Yang Ye, Liangchun Li, Ligen Lin
Mangosteen (Garcinia mangostana, Clusiaceae) is called "queen of fruit" in Southeast Asia. In the current study, three dimeric xanthones, garcinoxanthones A-C, and four monomeric xanthones, garcinoxanthones D-G, together with 18 known xanthones, were isolated from the pericarps of G. mangostana, collected in Thailand. The structures of garcinoxanthones A-G were elucidated by analysis of their 1D and 2D NMR and other spectroscopic data, and their absolute configurations were determined by the CD spectra. All seven compounds were tested for nitric oxide (NO) inhibitory activity on lipopolysaccharide (LPS)-stimulated RAW264...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27558585/efficacy-and-tolerability-of-meratrim-for-weight-management-a-randomized-double-blind-placebo-controlled-study-in-healthy-overweight-human-subjects
#20
RANDOMIZED CONTROLLED TRIAL
Venkateshwarlu Kudiganti, Raveendra Ramamurthy Kodur, Sushma Raveendra Kodur, Manjunath Halemane, Dheeraj Kumar Deep
BACKGROUND: Meratrim is a blend of two plant extracts obtained from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rinds. Previous studies have demonstrated that Meratrim is effective for weight management in obese individuals. The objective of this study was to assess the efficacy and tolerability of Meratrim in managing body weight in healthy overweight subjects. METHODS: Sixty participants with a mean BMI of 28.3 kg/m(2) were randomized into two groups receiving either 400 mg of Meratrim twice daily or two identical placebo capsules for a period of 16 weeks...
August 24, 2016: Lipids in Health and Disease
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