keyword
https://read.qxmd.com/read/38005293/-stevia-polyphenols-their-antimicrobial-and-anti-inflammatory-properties-and-inhibitory-effect-on-digestive-enzymes
#21
JOURNAL ARTICLE
Khaing Zar Myint, Zhuoyu Zhou, Qiandai Shi, Junming Chen, Xinyu Dong, Yongmei Xia
Polyphenols from stevia leaves (PPSs) are abundant byproducts from steviol glycoside production, which have been often studied as raw extracts from stevia extracts for their bioactivities. Herein, the PPSs rich in isochlorogenic acids were studied for their antimicrobial and anti-inflammatory properties, as well as their inhibitory effects on digestive enzymes. The PPSs presented stronger antibacterial activity against E. coli , S. aureus , P. aeruginosa , and B. subtilis than their antifungal activity against M...
November 13, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37963906/genome-wide-transcriptional-profiling-and-physiological-investigation-elucidating-the-molecular-mechanism-of-multiple-abiotic-stress-response-in-stevia-rebaudiana-bertoni
#22
JOURNAL ARTICLE
Poonam Pal, Mamta Masand, Shikha Sharma, Romit Seth, Gopal Singh, Sanatsujat Singh, Ashok Kumar, Ram Kumar Sharma
Considering the major source of plant-derived low/non-calorie steviol glycosides (SGs), comprehensive physiological, biochemical, and deep transcriptional investigations were conducted to explicit deeper insight into multiple abiotic stress responses in Stevia rebaudiana. The physiological indicators including photosynthesis, chlorophyll, relative water content, shoot growth, electrolyte leakage, and SG biosynthesis were negatively impacted under drought (DS), followed by salinity (SS) and waterlogging (WS)...
November 13, 2023: Scientific Reports
https://read.qxmd.com/read/37896037/influence-of-the-abiotic-elicitors-ag-salts-of-aspartic-acid-derivatives-self-organized-in-nanofibers-with-monomeric-and-dimeric-molecular-structures-on-the-antioxidant-activity-and-stevioside-content-in-micropropagated-stevia-rebaudiana-bert
#23
JOURNAL ARTICLE
Mariana Sichanova, Maria Geneva, Maria Petrova, Kamelia Miladinova-Georgieva, Elisaveta Kirova, Trendafil Nedev, Daniela Tsekova, Viktoria Ivanova, Antoaneta Trendafilova
The use of nanomaterials in biotechnology for the in vitro propagation of medical plants and the accumulation of certain biologically active metabolites is becoming an efficient strategy. This study aimed to evaluate the influence of the concentration (0, 1, 10, 50, and 100 mg L-1 ) of two types of nanofibers on the growth characteristics, the antioxidant status, and the production of steviol glycosides in micropropagated Stevia rebaudiana Bert. plantlets. The nanofibers were synthesized by aspartic acid derivatives (L-Asp) Ag salts self-organized into nanofibers with two different molecular structures: monomeric, containing one residue of L-Asp with one hydrophilic head which bonds one Ag ion (NF1-Ag salt); and dimeric, containing two residues of L-Asp with two hydrophilic heads which bond two Ag ions (NF2-Ag salt)...
October 14, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37895267/genome-wide-identification-and-expression-analysis-of-bzip-family-genes-in-stevia-rebaudiana
#24
JOURNAL ARTICLE
Mengyang Wu, Jinsong Chen, Weilin Tang, Yijie Jiang, Zhaoyong Hu, Dongbei Xu, Kai Hou, Yinyin Chen, Wei Wu
The basic (region) leucine zippers (bZIPs) are evolutionarily conserved transcription factors widely distributed in eukaryotic organisms. In plants, they are not only involved in growth and development, defense and stress responses and regulation of physiological processes but also play a pivotal role in regulating secondary metabolism. To explore the function related to the bZIP gene family in Stevia rebaudiana Bertoni, we identified 105 SrbZIP genes at the genome-wide level and classified them into 12 subfamilies using bioinformation methods...
October 9, 2023: Genes
https://read.qxmd.com/read/37836640/unlocking-the-therapeutic-potential-of-stevia-rebaudiana-bertoni-a-natural-antiglycating-agent-and-non-toxic-support-for-hdf-cell-health
#25
JOURNAL ARTICLE
Rinkey Shahu, Dinesh Kumar, Ahmad Ali, Kanchanlata Tungare, Khalid Mashay Al-Anazi, Mohammad Abul Farah, Renitta Jobby, Pamela Jha
Sugar carbonyl groups interact with protein amino groups, forming toxic components referred to as advanced glycation end products (AGEs). The glycation system (BSA, a model protein, and fructose) was incubated for five weeks at 37 °C in the presence and absence of Stevia leaf extract. The results indicated that the leaf extract (0.5 mg/mL) decreased the incidence of browning (70.84 ± 0.08%), fructosamine (67.27 ± 0.08%), and carbonyl content (64.04 ± 0.09%). Moreover, we observed an 81 ± 8...
September 25, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37791599/optimal-extraction-of-polysaccharides-from-stevia-rebaudiana-roots-for-protection-against-hydrogen-peroxide-induced-oxidative-damage-in-raw264-7-cells
#26
JOURNAL ARTICLE
Zhiyan Tang, Mingrui Zhang, Lan Gao, Yulong Bao, Ping Li, Ming Wang, Taili Shao, Guodong Wang, Chunyan Liu
Stevia rebaudiana boasts a wide range of medical and food applications and contains polysaccharides that exert beneficial effects against oxidative stress. In this study, we optimised the extraction of a polysaccharide (SRRP) from S. rebaudiana roots by employing a Box-Behnken design and response surface methodology. The optimal extraction conditions were as follows: 93.57 min, 71.67 °C, and a water-to-raw material ratio of 21.40 mL/g. Under these conditions, 14.00 ± 0...
October 4, 2023: Natural Product Research
https://read.qxmd.com/read/37726319/meta-topolin-induced-mass-shoot-multiplication-and-biosynthesis-of-valuable-secondary-metabolites-in-stevia-rebaudiana-bertoni-bioreactor-culture
#27
JOURNAL ARTICLE
Agata Ptak, Agnieszka Szewczyk, Magdalena Simlat, Alicja Błażejczak, Marzena Warchoł
Stevia rebaudiana Bertoni possesses various medicinal and food industrial applications. This study is the first to explore the effect of the cytokinins meta-Topolin (mT; 6-(3-hydroxybenzylamino) purine), zeatin, kinetin, and BAP (6-benzylaminopurine) at concentrations of 0 (control), 5, 10, and 15 µM on shoot multiplication, as well as stevioside, rebaudioside A, phenolic acid, and flavonoid content in bioreactor cultures. The highest number of shoots (23.4 per explant) was obtained in the medium containing 5 μM of mT...
September 19, 2023: Scientific Reports
https://read.qxmd.com/read/37722610/improvement-and-regulation-of-steviol-glycoside-biosynthesis-in-stevia-rebaudiana-bertoni
#28
REVIEW
Pritom Biswas, Ankita Kumari, Arpan Modi, Nitish Kumar
Stevia rebaudiana Bertoni is a natural sweetener plant that is progressively used not only for its sweetening properties but also for its medicinal properties. The plant contains steviol glycoside (SG) which is reported to be up to 300 times sweeter than sucrose. The plant is said to have no side effects on human health and has been approved by FDA. On the basis of previous studies and available databases, this review discusses the extensive understanding of the different approaches for enhancements of SG in S...
September 16, 2023: Gene
https://read.qxmd.com/read/37686739/fermented-stevia-improves-alcohol-poisoning-symptoms-associated-with-changes-in-mouse-gut-microbiota
#29
JOURNAL ARTICLE
Qingmiao Ma, Masafumi Noda, Narandalai Danshiitsoodol, Masanori Sugiyama
We previously found that the continuous feeding of ethanol caused mice dysbiosis, in which the cecal microbiota were significantly altered, as compared with those in the non-feeding control group, especially in some bacterial genera involved in gut inflammation. In the present study, we have found that the fermented extract of stevia ( Stevia rebaudiana ) leaves with plant-derived lactic acid bacteria (LABs), Pediococcus pentosaceus LY45, improves the trimethylamine (TMA) productivity of cecal content, which can be used as an indicator of dysbiosis...
August 24, 2023: Nutrients
https://read.qxmd.com/read/37683384/integration-of-biochar-with-nitrogen-in-acidic-soil-a-strategy-to-sequester-carbon-and-improve-the-yield-of-stevia-via-altering-soil-properties-and-nutrient-recycling
#30
JOURNAL ARTICLE
Babit Kumar Thakur, Surbhi Sharma, Aditi Sharma, Shivani, Krishna Kumar Singh, Probir Kumar Pal
The health of agroecosystems is subsiding unremittingly, and the over-use of chemical fertilizers is one of the key reasons. It is hypothesized that integrating biochar, a carbon (C)-rich product, would be an effective approach to reducing the uses of synthetic fertilizers and securing crop productivity through improving soil properties and nutrient cycling. The bamboo biochar at different quantities (4-12 Mg ha-1 ) and combinations with chemical fertilizers were tested in stevia (Stevia rebaudiana) farming in silty clay acidic soil...
September 6, 2023: Journal of Environmental Management
https://read.qxmd.com/read/37677968/steviol-glycosides-from-stevia-rebaudiana-bertoni-mitigate-lipid-metabolism-abnormalities-in-diabetes-by-modulating-selected-gene-expression-an-in-vivo-study
#31
JOURNAL ARTICLE
Jakub Michał Kurek, Joanna Mikołajczyk-Stecyna, Zbigniew Krejpcio
In diabetes, in parallel to hyperglycaemia, elevated serum lipids are also diagnosed, representing a high-risk factor for coronary heart disease and cardiovascular complications. The objective of this study was to unravel the mechanisms that underlie the potential of steviol glycosides (stevioside or rebaudioside A) administered at two doses (500 or 2500 mg/kg body weight for 5 weeks) to regulate lipid metabolism. In this paper, the expression of selected genes responsible for glucose and lipid metabolism (Glut4, Pparγ, Cebpa, Fasn, Lpl and Egr1) in the peripheral tissues (adipose, liver and muscle tissue) was determined using quantitative real-time PCR method...
September 5, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37661183/isosteviol-attenuates-streptozotocin-mediated-diabetic-nephropathy-in-rats-by-upregulating-and-stimulating-adenosine-monophosphate-activated-protein-kinase
#32
JOURNAL ARTICLE
J Z Altamimi, N A Alfaris, G M Alshammari, R I Alagal, D H Aljabryn, M A Yahya
Diabetic nephropathy (DN) is the major microvascular complication of type 1 diabetes mellitus (T1DM). Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity was shown to mediate the pro-oxidant and inflammatory mechanisms underlying DN. Isosteviol (ISV), isolated from Stevia rebaudiana, has antioxidant and anti-inflammatory properties and alleviates non-alcoholic fatty liver disease and lethal septic shock by activating AMPK. The effect of ISV on DN is unknown. This study examined if ISV alleviates DN in T1DM in adult male rats by activating AMPK...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37625297/stevia-rebaudiana-leaves-fermented-by-lactobacillus-plantarum-exhibit-resistance-to-microorganisms-and-cancer-cell-lines-in-vitro-a-potential-sausage-preservative
#33
JOURNAL ARTICLE
Li-Juan Chai, Tianchan Lan, Zhiyuan Cheng, Jing Zhang, Yang Deng, Ying Wang, Yan Li, Fengwu Wang, Meizi Piao
Natural preservatives are causing a rethinking of current preservation means. As a sweetener resource, exploitation of Stevia rebaudiana leaves (SRLs) is still restricted due to human conventional cognition. Herein, Lactobacillus plantarum fermented SRLs containing diverse free secondary metabolites derived from microbial deglycosylation and bioenzymatic decomposition were investigated. The apparent resistance to typical foodborne bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomoas aeruginosa, Bacillus amyloliquefaciens) by fermented SRLs and their extracts were validated...
August 18, 2023: Food Chemistry
https://read.qxmd.com/read/37571265/antioxidant-activity-of-leaf-extracts-from-stevia-rebaudiana-bertoni-exerts-attenuating-effect-on-diseased-experimental-rats-a-systematic-review-and-meta-analysis
#34
REVIEW
Maria Papaefthimiou, Panagiota I Kontou, Pantelis G Bagos, Georgia G Braliou
Stevia ( Stevia rebaudiana Bertoni) is an aromatic plant known for its high sweetening power ascribed to its glycosides. Stevia also contains several bioactive compounds showing antioxidant, antiproliferative, antimicrobial, and anti-inflammatory activities. Since inflammation and oxidative stress play critical roles in the pathogenesis of many diseases, stevia emerges as a promising natural product that could support human health. In this study we set out to investigate the way stevia affects oxidative stress markers (e...
July 26, 2023: Nutrients
https://read.qxmd.com/read/37566994/oligosaccharides-increased-both-leaf-biomass-and-steviol-glycosides-content-of-stevia-rebaudiana
#35
JOURNAL ARTICLE
Yu Wang, Peiyu Xu, Wenxia Wang, Xiaochen Jia, Liping Zhu, Heng Yin
Steviol glycosides (SGs) are a variety of important natural sweeteners. They are 200-350 times sweeter than sucrose without calories. Currently, their production is still mainly dependent on extraction from Stevia rebaudiana Bertoni (stevia). Oligosaccharides are environmentally friendly elicitors that promote plant growth and accumulation of secondary metabolites. In the present study, different concentrations of chitosan oligosaccharides (COS) and alginate oligosaccharides (AOS) were applied to stevia to explore their effect on growth and SGs biosynthesis...
August 3, 2023: Plant Physiology and Biochemistry: PPB
https://read.qxmd.com/read/37561949/optimization-of-total-phenolic-content-total-flavonoid-content-and-anti-gout-properties-of-polyherbal-formulation
#36
JOURNAL ARTICLE
Lim Sin Yee, Mohd Fadzelly Abu Bakar, Norazlin Abdullah, Fazleen Izzany Abu Bakar, Sri Fatmawati
OBJECTIVES: An increase in gout prevalence has drawn attention among society and this situation drives the exploration of more favourable treatment using traditional medicinal plants which are rich in phenolic and flavonoid to avoid the side effects of modern medication. However, there are only few studies regarding the optimization of phytochemicals and anti-gout properties of medicinal plants and their combinations. The objectives of this study were to determine the optimal formulation of Strobilanthes crispus , Orthosiphon stamineus Benth and Stevia rebaudiana with maximum total phenolic and flavonoid contents as well as minimum IC50 of in vitro xanthine oxidase inhibitory activity and to examine their correlations among the formulations...
August 14, 2023: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/37547431/antimicrobial-and-cytotoxic-activity-of-ocimum-tenuiflorum-and-stevia-rebaudiana-mediated-silver-nanoparticles-an-in-vitro-study
#37
JOURNAL ARTICLE
Indumathy Pandiyan, Meignana Indiran Arumugham, Sri Sakthi Doraikannan, Pradeep Kumar Rathinavelu, Jayashri Prabakar, S Rajeshkumar
BACKGROUND: Silver nanoparticles (AgNPs) are the nanoparticles of silver between 1 nm and 100 nm in size. In this study, AgNPs were extracted from Ocimum tenuiflorum and Stevia rebaudiana which is a medicinal plant of Indian origin, worshipped by the Hindus and used in Ayurvedic medicine since ancient times. AIM: The aim of the study was to assess the antimicrobial and cytotoxic effect of AgNPs reinforced with the herb O. tenuiflorum and S. rebaudiana against oral pathogens...
2023: Contemporary Clinical Dentistry
https://read.qxmd.com/read/37522778/productivity-and-selenium-enrichment-of-stevia-in-hydroponic-and-soil-cultivation-systems-in-the-ararat-valley
#38
JOURNAL ARTICLE
M Babakhanyan, V Chavushyan, K Simonyan, L Ghalachyan, L Darbinyan, A Ghukasyan, Sh Zaqaryan, L Hovhannisyan
Hydroponics offers a viable solution for obtaining plant products that are rich in micronutrients and ultramicronutrients, such as selenium. Selenium plays a crucial role in strengthening the body's immune defense and acts as a potent antioxidant. Low levels of selenium have been associated with an increased risk of heart attacks, strokes, and cancer. Stevia rebaudiana Bertoni (SrB), a relatively new crop in plant cultivation, was the focus of the present study. SrB has numerous medicinal and prophylactic properties, and its leaves are rich in macro- and microelements, vitamins, and diterpene glycosides...
June 2023: Georgian Medical News
https://read.qxmd.com/read/37488560/stevia-stevia-rebaudiana-extract-ameliorates-insulin-resistance-by-regulating-mitochondrial-function-and-oxidative-stress-in-the-skeletal-muscle-of-db-db-mice
#39
JOURNAL ARTICLE
Jin-Young Han, Miey Park, Hae-Jeung Lee
BACKGROUND: Type 2 diabetes mellitus (T2DM), a growing health problem worldwide, is a metabolic disorder characterized by hyperglycemia due to insulin resistance and defective insulin secretion by pancreatic β-cells. The skeletal muscle is a central organ that consumes most of the insulin-stimulated glucose in the body, and insulin resistance can damage muscles in T2DM. Based on a strong correlation between diabetes and muscles, we investigated the effects of stevia extract (SE) and stevioside (SV) on the skeletal muscle of diabetic db/db mice...
July 24, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37470317/stevia-vs-triple-antibiotic-paste-an-intracanal-battle
#40
JOURNAL ARTICLE
Raghavendra Havale, Shrutha Santhebachalli Prakasha, Sharon Elizebeth George, Namratha Tharay, Shiny Raj, Chandrabanda Bhavana, Afreen Anjum Syed, Anand Kumar, Venkatesh Naik
BACKGROUND: Intracanal medicaments are vital in treating the infections of the deciduous dentition due to the large percentage of accessory canals that hasten the microbial spread to the periradicular region. Though countless medicaments have been produced to reduce the microbial load and aid symptomatic relief, they still do not fulfill every function of an ideal medicament. OBJECTIVES: The aim of the present study was to evaluate and compare the antimicrobial efficacy of Stevia rebaudiana (S...
July 20, 2023: Dental and Medical Problems
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