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Stevia rebaudiana

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https://www.readbyqxmd.com/read/28792778/stevia-rebaudiana-bertoni-a-natural-alternative-for-treating-diseases-associated-with-metabolic-syndrome
#1
Areli Carrera-Lanestosa, Yolanda Moguel-Ordóñez, Maira Segura-Campos
Stevia rebaudiana (SR) is often used by the food industry due to its steviol glycoside content, which is a suitable calorie-free sweetener. Further, both in vitro and in vivo studies indicate that these glycosides and the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, and anticancer. This work reviews the antiobesity, antihyperglycemic, antihypertensive, and antihyperlipidemic effects of the majority of glycosides and aqueous/alcoholic extracts from the leaves, flowers, and roots of the SR...
August 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28762654/development-of-an-hplc-procedure-to-identify-known-and-detect-novel-c-13-oligosaccharide-moieties-in-diterpene-glycosides-from-stevia-rebaudiana-bertoni-bertoni-asteraceae-structure-elucidation-of-rebaudiosides-v-and-w
#2
Wilmer H Perera, Ion Ghiviriga, Douglas L Rodenburg, Raquel Carvalho, Kamilla Alves, James D McChesney
As an aid for structure elucidation of new steviol glycosides, reversed-phase C18 high-performance liquid chromatography method was developed with several previously characterized diterpene glycosides, to identify known and detect novel aglycone-C13 oligosaccharide moieties and indirectly identify C-19 interlinkages. Elution order of several diterpene glycosides and their aglycone-C13 oligosaccharide substituted with different sugar arrangements were also summarized. Comparison of the retention time of a product obtained after alkaline hydrolysis with the alycone-C-13 portions of known compounds reported herein allowed us to deduce the exact positions of the sugars in the C-13 oligosaccharide portion...
August 1, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28758125/antihyperglycemic-and-antihyperlipidemic-activity-of-hydroponic-stevia-rebaudiana-aqueous-extract-in-hyperglycemia-induced-by-immobilization-stress-in-rabbits
#3
Anush Aghajanyan, Zaruhi Movsisyan, Armen Trchounian
Diabetes mellitus (DM) is a serious worldwide problem related to human hyperglycemia. Thus, herbal preparations with antihyperglycemic properties especially leaf extracts of hydroponic Stevia rebaudiana (SR) would be useful in hyperglycemia treatment. The antihyperglycemic potential of this medicinal plant grown using hydroponics methods has been evaluated. Significant reduction of some biochemical characteristics for sugars and fatty acids in blood, liver, and muscle especially fasting glucose levels, serum triglycerides, LDL-cholesterol, total cholesterol levels, and increased HDL-cholesterol ones was shown with SR aqueous extract treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28742480/from-ca%C3%A3-eh%C3%A3-to-a-commercial-sweetener-the-diterpenoid-glycosides-of-stevia-rebaudiana
#4
James R Hanson
The isolation, structure elucidation, chemistry, biosynthesis and biological activity of the sweet steviol glycosides from Stevia rebaudiana, are reviewed.
December 1, 2016: Science Progress
https://www.readbyqxmd.com/read/28738695/a-research-on-the-genotoxicity-of-stevia-in-human-lymphocytes
#5
Aslı Uçar, Serkan Yılmaz, Şemsigül Yılmaz, Mustafa Sefa Kılıç
Stevia extracts are obtained from Stevia rebaudiana commonly used as natural sweeteners. It is ∼250-300 times sweeter than sucrose. Common use of stevia prompted us to investigate its genotoxicity in human peripheral blood lymphocytes. Stevia (active ingredient steviol glycoside) was dissolved in pure water. Dose selection was done using ADI (acceptable daily intake) value. Negative control (pure water), 1, 2, 4, 8 and 16 μg/ml concentrations which were equivalent to ADI/4, ADI/2, ADI, ADI × 2 and ADI × 4 of Stevia were added to whole-blood culture...
July 24, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28720959/fortification-of-the-whey-protein-isolate-antioxidant-and-antidiabetic-activity-with-fraction-rich-in-phenolic-compounds-obtained-from-stevia-rebaudiana-bert-bertoni-leaves
#6
Paula Gimenez Milani, Maysa Formigoni, Yago Carvalho Lima, Silvano Piovan, Giuliana Maria Ledesma Peixoto, Daiane Montoia Camparsi, Willian do Nascimento da Silva Rodrigues, Jordana Quaglia Pereira da Silva, Alexandre da Silva Avincola, Eduardo Jorge Pilau, Cecília Edna Mareze da Costa, Silvio Cláudio da Costa
A stevia fraction (ASF) free of steviol glycosides was extracted from Stevia rebaudiana leaves (Stevia UEM-13). ASF essentially constitutes phenolic compounds (52.42%), which were identified by liquid chromatography tandem mass spectrometry (LC-MS/MS) as caffeic acid, quercetin-3-o-glycoside, cyanidin-3-glucoside, kaempferol, quercetin, apigenin, rozmarinic acid, chlorogenic acid and dicaffeoylquinic acid. ASF was used as a multi-functional source of phenolic compounds to fortify the whey protein isolate (WPI) obtained by membrane separation...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28714761/gamma-irradiation-of-medicinally-important-plants-and-the-enhancement-of-secondary-metabolite-production
#7
P Vivek Vardhan, Lata I Shukla
PURPOSE: The profitable production of some important plant-based secondary metabolites (ginsenosides, saponins, camptothecin, shikonins etc.) in vitro by gamma irradiation is a current area of interest. We reviewed different types of secondary metabolites, their mode of synthesis and effect of γ-radiation on their yield for different plants, organs and in vitro cultures (callus, suspension, hairy root). Special effort has been made to review the biochemical mechanisms underlying the increase in secondary metabolites...
July 17, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28691017/reduction-of-the-oxidative-stress-status-using-steviol-glycosides-in-a-fish-model-cyprinus-carpio
#8
Livier Mireya Sánchez-Aceves, Octavio Dublán-García, Leticia-Xochitl López-Martínez, Karen Adriana Novoa-Luna, Hariz Islas-Flores, Marcela Galar-Martínez, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván
Steviol glycosides are sweetening compounds from the Stevia rebaudiana Bertoni plant. This product is considered safe for human consumption and was approved as a food additive by the Food and Drugs Administration (FDA) and European Food Safety Authority (EFSA). Its effects on the ecosystem have not been studied in depth; therefore, it is necessary to carry out ecotoxicological studies in organisms such as Cyprinus carpio. The present study aimed to evaluate the antioxidant activity by SGs on diverse tissues in C...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28666887/stevia-and-stevioside-protect-against-cisplatin-nephrotoxicity-through-inhibition-of-erk1-2-stat3-and-nf-%C3%AE%C2%BAb-activation
#9
Iva Potočnjak, Dalibor Broznić, Marija Kindl, Matija Kropek, Sanda Vladimir-Knežević, Robert Domitrović
We investigated the effect of natural sweetener Stevia rebaudiana and its constituent stevioside in cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 10, 20, and 50 mg/kg body weight of Stevia rebaudiana ethanol extract (SE) or stevioside 50 mg/kg, 48 h after intraperitoneal administration of CP (13 mg/kg). Two days later, CP treatment resulted in histopathological changes showing kidney injury. Increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), and heme oxygenase-1 (HO-1) in mice kidneys suggested oxidative stress...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28645057/effects-of-salinity-and-short-term-elevated-atmospheric-co2-on-the-chemical-equilibrium-between-co2-fixation-and-photosynthetic-electron-transport-of-stevia-rebaudiana-bertoni
#10
Sayed Hussin, Nicole Geissler, Mervat M M El-Far, Hans-Werner Koyro
The effect of water salinity on plant growth and photosynthetic traits of Stevia rebaudiana was investigated to determine its level and mechanisms of salinity tolerance. It was also attempted to assess how short-term elevated CO2 concentration would influence the boundaries and mechanisms of its photosynthetic capacity. The plants were grown in gravel/hydroponic system under controlled greenhouse conditions and irrigated with four different salinity levels (0, 25, 50 and 100 mol m(-3)NaCl). Low salinity did not significantly alter the plant fresh weight, which was substantially decreased by 67% at high salinity treatment...
June 15, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28500994/salt-tolerance-mechanisms-induced-in-stevia-rebaudiana-bertoni-effects-on-mineral-nutrition-antioxidative-metabolism-and-steviol-glycoside-content
#11
Daniel Cantabella, Abel Piqueras, José Ramón Acosta-Motos, Agustina Bernal-Vicente, José A Hernández, Pedro Díaz-Vivancos
In order to cope with challenges linked to climate change such as salinity, plants must develop a wide spectrum of physiological and molecular mechanisms to rapidly adapt. Stevia rebaudiana Bertoni plants are a case in point. According to our findings, salt stress has no significant effect on plant growth in these plants, which accumulate sodium (Na(+)) in their roots, thus avoiding excessive Na(+) accumulation in leaves. Furthermore, salt stress (NaCl stress) increases the potassium (K(+)), calcium (Ca(2+)), chloride ion (Cl(-)) and proline concentrations in Stevia leaves, which could contribute to osmotic adjustment...
June 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28490088/antioxidant-activities-of-aqueous-extract-from-stevia-rebaudiana-stem-waste-to-inhibit-fish-oil-oxidation-and-identification-of-its-phenolic-compounds
#12
Hui Yu, Gangqiang Yang, Minoru Sato, Toshiyasu Yamaguchi, Toshiki Nakano, Yinci Xi
We investigated the potential for exploiting Stevia rebaudiana stem (SRS) waste as a source of edible plant-based antioxidants finding for the first time that the hot water extract of SRS had significantly higher antioxidant activity against fish oil oxidation than that of the leaf, despite SRS extract having lower total phenolic content, DPPH radical scavenging activity and ORAC values. To locate the major antioxidant ingredients, SRS extract was fractionated using liquid chromatography. Five phenolic compounds (primary antioxidant components in activity-containing fractions) were identified by NMR and HR-ESI-MS: vanillic acid 4-O-β-d-glucopyranoside (1), protocatechuic acid (2), caffeic acid (3), chlorogenic acid (4) and cryptochlorogenic acid (5)...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28476985/size-dependent-effects-of-antifungal-phytogenic-silver-nanoparticles-on-germination-growth-and-biochemical-parameters-of-rice-oryza-sativa-l-maize-zea-mays-l-and-peanut-arachis-hypogaea-l
#13
Tollamadugu N V K V Prasad, Shaik Adam, Pasupuleti Visweswara Rao, Balam Ravindra Reddy, Thimmavajjula Giridhara Krishna
Advancement in materials synthesis largely depends up on their diverse applications and commercialisation. Antifungal effects of phytogenic silver nanoparticles (AgNPs) were evident, but the reports on the effects of the same on agricultural crops are scant. Herein, we report for the first time, size dependent effects of phytogenic AgNPs (synthesised using Stevia rebaudiana leaf extract) on the germination, growth and biochemical parameters of three important agricultural crops viz., rice (Oryza sativa L), maize (Zea mays L) and peanut (Arachis hypogaea L)...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28372164/optimization-of-microwave-assisted-extraction-of-total-extract-stevioside-and-rebaudioside-a-from-stevia-rebaudiana-bertoni-leaves-using-response-surface-methodology-rsm-and-artificial-neural-network-ann-modelling
#14
Kashif Ameer, Seong-Woo Bae, Yunhee Jo, Hyun-Gyu Lee, Asif Ameer, Joong-Ho Kwon
Stevia rebaudiana (Bertoni) consists of stevioside and rebaudioside-A (Reb-A). We compared response surface methodology (RSM) and artificial neural network (ANN) modelling for their estimation and predictive capabilities in building effective models with maximum responses. A 5-level 3-factor central composite design was used to optimize microwave-assisted extraction (MAE) to obtain maximum yield of target responses as a function of extraction time (X1: 1-5min), ethanol concentration, (X2: 0-100%) and microwave power (X3: 40-200W)...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28364791/effect-of-nitrogen-sources-on-some-morphological-characteristics-of-in-vitro-stevia-rebaudiana-bertoni
#15
F Akbari, A Arminian, D Kahrizi, A Fazeli
Stevia rebaudiana Bertoni belongs to Asteraceae family that leaves 200-300 times sweeter than sugar. Low seed fertility is one of the most important problems in Stevia production. So, Plant tissue culture is an efficient method for mass propagation of Stevia. In this research, we studied the effect of various concentrations of nitrogen on some morphological traits of stevia under in vitro conditions. We used axillary nodes as explants and they were cultured on Murashige and Skoog (MS) medium containing inorganic nitrogen sources i...
February 28, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28363166/insight-into-anti-diabetic-effect-of-low-dose-of-stevioside
#16
Vladimirka Ilić, Saša Vukmirović, Nebojša Stilinović, Ivan Čapo, Milan Arsenović, Boris Milijašević
Diabetes mellitus is a chronic disease characterized by abnormal carbohydrate, lipid and protein metabolism due to a lack of insulin or reduced target cell sensitivity to insulin. Stevia rebaudiana is an important source of biochemically active substances with proven anti-diabetic effect. The aim of this study was to determine anti-diabetic effects of the low dose of stevioside in NMRI Haan mice. Aqueous stevioside solution (20mg/kg body weight) was administered by oral route of administration. Anti-diabetic effect of stevioside was estimated by oral glucose tolerance test, adrenaline test after a 10day stevioside treatment, and alloxan induced hyperglycaemia in mice (two experimental groups, 10day stevioside treatment before and after alloxan administration)...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28361903/steviol-glycosides-enhance-pancreatic-beta-cell-function-and-taste-sensation-by-potentiation-of-trpm5-channel-activity
#17
Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets, Rudi Vennekens
Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca(2+)-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner...
March 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28351677/toxicological-evaluation-of-ethanolic-extract-from-stevia-rebaudiana-bertoni-leaves-genotoxicity-and-subchronic-oral-toxicity
#18
Qiannan Zhang, Hui Yang, Yongning Li, Haibo Liu, Xudong Jia
Stevia rebaudiana Bertoni leaves have a long history of use as an abundant source of sweetener. The aqueous extract of stevia leaves and the predominant constitutes steviol glycosides have been intensively investigated. However, rare studies provided toxicological evaluation of bioactive components in the polar extract regarding their safety on human health. This study aimed to evaluate the toxicity of ethanolic extract of Stevia rebaudiana Bertoni leaves through a battery of in vitro and in vivo tests. Negative results were unanimously obtained from bacterial reverse mutation assay, mouse bone marrow micronucleus assay and mouse sperm malformation assay...
March 25, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28346877/stevia-rebaudiana-bertoni-effect-on-the-hemolytic-potential-of-listeria-monocytogenes
#19
S Sansano, A Rivas, M C Pina-Pérez, A Martinez, D Rodrigo
The effect of Stevia rebaudiana Bertoni on the hemolytic potential of Listeria monocytogenes was studied by means of the assessment of the Listeriolysin O (LLO) production. The three factors under study, stevia concentration in the range [0-2.5] % (w/v), incubation temperature (10 and 37°C), and exposure time (0-65h) significantly affected (p≤0.05) the hemolytic activity of L. monocytogenes. Results showed that at the lower incubation temperature the hemolytic potential of the bacterium was significantly reduced, from 100% at 37°C to 8% at 10°C (after 65h of incubation) in unsupplemented substrate (0% stevia)...
March 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28343388/development-and-validation-of-an-enzymatic-method-to-determine-stevioside-content-from-stevia-rebaudiana
#20
Somsiri Udompaisarn, Dumrongkiet Arthan, Jamorn Somana
An enzymatic method for specific determination of stevioside content was established. Recombinant β-glucosidase BT_3567 (rBT_3567) from Bacteroides thetaiotaomicron HB-13 exhibited selective hydrolysis of stevioside at β-1,2-glycosidic bond to yield rubusoside and glucose. Coupling of this enzyme with glucose oxidase and peroxidase allowed for quantitation of stevioside content in Stevia samples by using a colorimetric-based approach. The series of reactions for stevioside determination can be completed within 1 h at 37 °C...
April 19, 2017: Journal of Agricultural and Food Chemistry
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