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https://www.readbyqxmd.com/read/29469913/revisiting-the-carrageenan-controversy-do-we-really-understand-the-digestive-fate-and-safety-of-carrageenan-in-our-foods
#1
REVIEW
Shlomit David, Carmit Shani Levi, Lulu Fahoum, Yael Ungar, Esther G Meyron-Holtz, Avi Shpigelman, Uri Lesmes
Carrageenan (CGN), a family of marine polysaccharides isolated from seaweeds, has been at the heart of considerable debate in recent years. To date, CGN is generally recognized as safe based on a history of safe use, various acute toxicology studies and some recent chronic toxicology tests. This review offers readers an overview of evidence on CGN characteristics and digestive fate that highlight various gaps in our understanding. Specifically, three unresolved gaps are identified. Firstly, little information can be found on the current levels of public exposure to CGN...
February 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29468401/the-role-of-the-genitourinary-microbiome-in-pediatric-urology-a-review
#2
REVIEW
Daniel Gerber, Catherine S Forster, Michael Hsieh
PURPOSE OF REVIEW: In this review, we highlight the effects of the microbiome on urologic diseases that affect the pediatric patient. RECENT FINDINGS: Perturbations in the urinary microbiome have been shown to be associated with a number of urologic diseases affecting children, namely urinary tract infection, overactive bladder/urge urinary incontinence, and urolithiasis. Recently, improved cultivation and sequencing technologies have allowed for the discovery of a significant and diverse microbiome in the bladder, previously assumed to be sterile...
February 22, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29468141/impact-of-the-gut-microbiota-on-intestinal-immunity-mediated-by-tryptophan-metabolism
#3
REVIEW
Jing Gao, Kang Xu, Hongnan Liu, Gang Liu, Miaomiao Bai, Can Peng, Tiejun Li, Yulong Yin
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. Recent discoveries have underscored that changes in the microbiota modulate the host immune system by modulating Trp metabolism. Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacterial Trp metabolites (indole, indolic acid, skatole, and tryptamine) have profound effects on gut microbial composition, microbial metabolism, the host's immune system, the host-microbiome interface, and host immune system-intestinal microbiota interactions...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29464345/prognostic-impact-of-bacterobilia-on-morbidity-and-postoperative-management-after-pancreatoduodenectomy-a-systematic-review-and-meta-analysis
#4
Benjamin Müssle, Sebastian Hempel, Christoph Kahlert, Marius Distler, Jürgen Weitz, Thilo Welsch
BACKGROUND: Intraoperative bile analysis during pancreatoduodenectomy (PD) is performed routinely at specialized centers worldwide. However, it remains controversial if and how intraoperative bacterobilia during PD affects morbidity and its management. The aim of the study was a systematic review and meta-analysis of intraoperative bacterobilia and its impact on patient outcome after PD. METHODS: Five relevant outcomes of interest were defined, and a systematic review of the literature with meta-analysis was performed according to the PRISMA guidelines...
February 20, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29461261/from-dysmotility-to-virulent-pathogens-implications-of-opioid-use-in-the-icu
#5
Lee-Anne Chapple, Adam Deane
PURPOSE OF REVIEW: Gastrointestinal dysmotility occurs frequently in the critically ill. Although the causes underlying dysmotility are multifactorial, both pain and its treatment with exogenous opioids are likely causative factors. The purpose of this review is to describe the effects of pain and opioids on gastrointestinal motility; outline the rationale for and evidence supporting the administration of opioid antagonists to improve dysmotility; and describe the potential influence opioids drugs have on the intestinal microbiome and infectious complications...
February 15, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29460306/pathophysiology-of-axial-spondyloarthritis-consensus-and-controversies
#6
REVIEW
A de Koning, J W Schoones, D van der Heijde, F A van Gaalen
Axial spondyloarthritis (axSpA) is a common inflammatory arthritis of the sacroiliac joints and the spine. The best-known and most studied form of axSpA is ankylosing spondylitis. In this review, we provide a brief overview of the pathophysiology of axSpA. In addition, we performed a quantitative text analysis of reviews on the pathogenesis of axSpA published in the last ten years to establish the current consensus in various fields of research into the pathogenesis of axSpA. There appears to be broad consensus on genetic risk factors and the involvement of the immune system in the initiation phase of the disease although little consensus was found on which specific immune cells drive disease...
February 20, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29458272/difference-between-right-sided-and-left-sided-colorectal-cancers-from-embryology-to-molecular-subtype
#7
Seung Yoon Yang, Min Soo Cho, Nam Kyu Kim
Colorectal cancer is one of the most common malignancies in the world, and it exhibits differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumor. Differences in the microbiome, clinical characteristics, and chromosomal and molecular characteristics have been reported between the right and left side of the colon. Areas covered: This review focuses on the latest developments in epidemiological and chromosomal and molecular studies, which have enhanced our understanding on the underlying genetic and immunological differences between the right-sided colon and the left-sided colorectum in metastatic colorectal cancer...
February 19, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29453631/occupational-animal-allergy
#8
REVIEW
Gregg M Stave
PURPOSE OF REVIEW: This review explores animal allergen exposure in research laboratories and other work settings, focusing on causes and prevention. RECENT FINDINGS: (1) Consistent with the hygiene hypothesis, there is new evidence that early childhood exposure to pets produces changes in the gut microbiome that likely lead to a lower risk of allergy. (2) Anaphylaxis from laboratory animal bites occurs more frequently than suggested by prior literature. (3) Animal allergens represent an occupational hazard in a wide variety of work settings ranging from fields that work with animals to public settings like schools and public transportation where allergens are brought into or are present in the workplace...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29453413/depression-and-obesity-evidence-of-shared-biological-mechanisms
#9
REVIEW
Yuri Milaneschi, W Kyle Simmons, Elisabeth F C van Rossum, Brenda Wjh Penninx
Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals. The relationship between these conditions is bidirectional: the presence of one increases the risk for developing the other. It has thus become crucial to gain a better understanding of the mechanisms responsible for the intertwined downward physiological spirals associated with both conditions. The present review focuses specifically on shared biological pathways that may mechanistically explain the depression-obesity link, including genetics, alterations in systems involved in homeostatic adjustments (HPA axis, immuno-inflammatory activation, neuroendocrine regulators of energy metabolism including leptin and insulin, and microbiome) and brain circuitries integrating homeostatic and mood regulatory responses...
February 16, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29453411/the-impact-of-a-helminth-modified-microbiome-on-host-immunity
#10
REVIEW
Tara P Brosschot, Lisa A Reynolds
Intestinal helminths have well-characterized modulatory effects on mammalian immune pathways. Ongoing helminth infection has been associated with both the suppression of allergies and an altered susceptibility to microbial infections. Enteric helminths share a niche with the intestinal microbiota, and the presence of helminths alters the microbiota composition and the metabolic signature of the host. Recent studies have demonstrated that the helminth-modified intestinal microbiome has the capacity to modify host immune responses even in the absence of live helminth infection...
February 16, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29453029/systems-biology-of-the-human-microbiome
#11
REVIEW
Beatriz Peñalver Bernabé, Lauren Cralle, Jack A Gilbert
Recent research has shown that the microbiome-a collection of microorganisms, including bacteria, fungi, and viruses, living on and in a host-are of extraordinary importance in human health, even from conception and development in the uterus. Therefore, to further our ability to diagnose disease, to predict treatment outcomes, and to identify novel therapeutics, it is essential to include microbiome and microbial metabolic biomarkers in Systems Biology investigations. In clinical studies or, more precisely, Systems Medicine approaches, we can use the diversity and individual characteristics of the personal microbiome to enhance our resolution for patient stratification...
February 13, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29452257/microbiota-changes-impact-on-sexually-transmitted-infections-and-the-development-of-pelvic-inflammatory-disease
#12
Nathalie Loeper, Simon Graspeuntner, Jan Rupp
The integrity of the human urogenital microbiome is crucial for women's health and well-being. An imbalance of the urogenital microbiota increases the risk for sexually transmitted infections. In this review, we discuss the microbiota composition of the female urogenital tract and its role in protecting from sexually transmitted infections and the emergence of pelvic inflammatory disease.
February 13, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29449651/beyond-streptococcus-mutans-clinical-implications-of-the-evolving-dental-caries-aetiological-paradigms-and-its-associated-microbiome
#13
N Philip, B Suneja, L Walsh
Aetiological concepts of dental caries have evolved over the years from being considered as a disease initiated by nonspecific microorganisms, to being regarded as an 'infectious' disease caused by specific bacteria, to the current paradigms that emphasise a 'mixed bacterial-ecological approach' as being responsible for lesion initiation and pathogenesis. These aetiological paradigms are not just intellectual concepts but have important implications on how clinicians manage this age-old disease in the twenty-first century...
February 16, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29447847/perinatal-selective-serotonin-reuptake-inhibitor-ssri-effects-on-body-weight-at-birth-and-beyond-a-review-of-animal-and-human-studies
#14
REVIEW
Sarah M Hutchison, Louise C Mâsse, Jodi L Pawluski, Tim F Oberlander
The long-term impact of selective serotonin reuptake inhibitor (SSRI) antidepressant treatment during pregnancy and postpartum on offspring outcomes is still not clear. Specifically, perinatal SSRI exposure may have long-term consequences for body weight and related health outcomes in the newborn period and beyond. This review focuses on the impact of perinatal SSRI exposure on weight using human and animal findings. The impact of maternal mood is also explored. We propose potential mechanisms for weight changes, including how early alterations in serotonin signaling may have implications for weight via changes in metabolism and motor development...
February 12, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29447695/cervicovaginal-microbiota-and-reproductive-health-the-virtue-of-simplicity
#15
REVIEW
Melis N Anahtar, David B Gootenberg, Caroline M Mitchell, Douglas S Kwon
Cervicovaginal microbiota play a critical role in women's health and reproductive outcomes. Despite being one of the simplest commensal bacterial communities in the human body, we are only beginning to appreciate its complex dynamic nature and important role in host immune modulation. In this review, we discuss the "optimal" cervicovaginal bacterial community composition, the impact of microbiota on gynecologic and obstetric outcomes, and the hurdles to developing a deeper mechanistic understanding of the function of the cervicovaginal microbiome...
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29447350/soil-protists-a-fertile-frontier-in-soil-biology-research
#16
Stefan Geisen, Edward A D Mitchell, Sina Adl, Michael Bonkowski, Micah Dunthorn, Flemming Ekelund, Leonardo D Fernández, Alexandre Jousset, Valentyna Krashevska, David Singer, Frederick W Spiegel, Julia Walochnik, Enrique Lara
Protists include all eukaryotes except plants, fungi and animals. They are an essential, yet often forgotten, component of the soil microbiome. Method developments have now furthered our understanding of the real taxonomic and functional diversity of soil protists. They occupy key roles in microbial foodwebs as consumers of bacteria, fungi and other small eukaryotes. As parasites of plants, animals and even of larger protists, they regulate populations and shape communities. Pathogenic forms play a major role in public health issues as human parasites, or act as agricultural pests...
February 13, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29440648/publisher-correction-maturation-of-the-gut-microbiome-and-risk-of-asthma-in-childhood
#17
Jakob Stokholm, Martin J Blaser, Jonathan Thorsen, Morten A Rasmussen, Johannes Waage, Rebecca K Vinding, Ann-Marie M Schoos, Asja Kunøe, Nadia R Fink, Bo L Chawes, Klaus Bønnelykke, Asker D Brejnrod, Martin S Mortensen, Waleed Abu Al-Soud, Søren J Sørensen, Hans Bisgaard
The originally published version of this Article contained an incorrect version of Figure 3 that was introduced following peer review and inadvertently not corrected during the production process. Both versions contain the same set of abundance data, but the incorrect version has the children's asthma status erroneously disconnected from the abundance data, thereby producing the non-representative p values and graphic presentations. These errors have now been rectified, with the correct version of Figure 3 replaced in both the PDF and HTML versions of the Article...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29439457/immune-landscape-of-breast-cancers
#18
REVIEW
Divya Nagarajan, Stephanie E B McArdle
Breast cancer is a very heterogeneous disease, both at a molecular and a histological level. Five intrinsic subtypes were initially identified-Luminal-A, Luminal-B, HER2⁺, Triple negative/basal like (TNBC) and normal like-subsequently expanded to seven (Basal-like-1 and 2, mesenchymal, mesenchymal stem-like, luminal androgen receptor, immuno-modulatory and unstable). Although genetic and epigenetic changes are key pathogenic events, the immune system plays a substantial role in promoting progression and metastasis...
February 11, 2018: Biomedicines
https://www.readbyqxmd.com/read/29436707/the-molecular-pathology-of-cancer-from-pan-genomics-to-post-genomics
#19
REVIEW
David G Huntsman, Marc Ladanyi
As the cancer genomics of most major cancer types have been comprehensively catalogued over the past decade through a variety of national and international efforts, the delineation of cancer subtypes has been refined, and our understanding of critical cancer drivers and of the potentially targetable vulnerabilities they create has grown tremendously. The 2018 Annual Review Issue of The Journal of Pathology provides in-depth assessments of how these pan-genomic approaches have enabled advances in cancer classification, targeted therapy selection, and assessment of cancer progression, all of which are now genomically informed, using several cancer types as examples...
February 13, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29433833/macrophage-phagocytosis-cracking-the-defect-code-in-copd
#20
REVIEW
Jamil Jubrail, Nisha Kurian, Florence Niedergang
In the normal non-diseased lung, various macrophage populations maintain homeostasis and sterility by ingesting and clearing inhaled particulates, pathogens and apoptotic cells from the local environment. This process of phagocytosis leads to the degradation of the internalized material, coordinated induction of gene expression, antigen presentation and cytokine production, implicating phagocytosis as a central regulator of innate immunity. Phagocytosis is extremely efficient and any perturbation of this function is deleterious...
December 2017: Biomedical Journal
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