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M Ashwin Reddy, Zishan Naeem, Catriona Duncan, Fergus Robertson, Jane Herod, Adam Rennie, Alki Liasis, Dorothy Ann Thompson, Mandeep Sagoo
BACKGROUND: Intra-arterial chemotherapy (IAC) for retinoblastoma has been documented as causing visual loss and ocular motility problems. A lack of safety data has precluded its acceptance in all centres. METHODS: Retrospective cohort study of patients with retinoblastoma from 2013 to 2015 who had a healthy foveola and relapsed following systemic chemotherapy. All required IAC. The correlation of complications with doses of melphalan +/- topotecan used and putative catheterisation complications was assessed...
April 21, 2017: British Journal of Ophthalmology
Sian E Handley, Vasiliki S Panteli, Alki Liasis
Trans-synaptic retrograde degeneration (TRD) in the human visual system has been established. However there are few studies demonstrating macular thinning of the Retinal Ganglion cell Layer and/or Inner Plexiform layer (RGCL-IPL), corresponding to an acquired homonymous hemianopia. We report a 17 year old with a homonymous hemianopia, secondary to a hemispherectomy for intractable epilepsy. Three years following hemispherectomy, Optical Coherence Tomography (OCT) revealed evidence of TRD, corresponding to his complete homonymous hemianopia...
April 2017: Neuro-ophthalmology
Sian E Handley, Faraneh Vargha-Khadem, Richard J Bowman, Alki Liasis
PURPOSE: To investigate visual function in adults post hemispherectomy in childhood. DESIGN: Non-comparative case series. METHODS: All participants underwent visual acuity, binocular function, visual field, optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL), and monocular pattern reversal visually evoked potentials (prVEP). PARTICIPANTS: 6 adults who had a hemispherectomy in childhood (median 21...
February 22, 2017: American Journal of Ophthalmology
Sian E Handley, Alki C Liasis
PURPOSE: To demonstrate how multichannel visual evoked potentials (VEPs) can provide quantitative measures of visual function in children with marked cortical anatomy abnormalities. METHODS: Four children with marked brain pathology (2 holoprosencephaly, 2 giant interhemispheric cysts with hydrocephalus) underwent pattern reversal and flash VEP recordings from 16 equally distributed electrodes. Voltage maps of the major VEP components were constructed, and their distributions were compared to the magnetic resonance imaging (MRI) findings...
January 9, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Charis-Konstantina Kontopoulou, Epifanios Liasis, Pietro P M Iannetta, Anastasia Tampakaki, Dimitrios Savvas
BACKGROUND: Testing rhizobial inoculation of common bean (Phaseolus vulgaris L.) in hydroponics enables accurate quantification of biological N2 -fixation (BNF) and provides information about the potential of reducing inorganic-N fertilizer use. In view of this background, common bean grown on pumice was inoculated with Rhizobium tropici CIAT899 (Rt) and supplied with either full-N (total-nitrogen 11.2 mM) or 1/3 of full-N, or N-free nutrient solution (NS). BNF was quantified at the early pod filling stage using the (15) N natural abundance method...
January 10, 2017: Journal of the Science of Food and Agriculture
Maria Flynn, Alki Liasis, Mark Gardner, Tony Towell
Mismatch negativity (MMN) has been characterised as a 'pre-attentive' component of an event-related potential (ERP) that is related to discrimination and error prediction processes. The aim of the current experiment was to establish whether visual MMN could be recorded to briefly presented, backward and forward masked visual stimuli, given both below and above levels of subjective experience. Evidence of visual MMN elicitation in the absence of the ability to consciously report stimuli would provide strong evidence for the automaticity of the visual MMN mechanism...
February 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Lampros Liasis, George Malietzis, George Galyfos, Thanos Athanasiou, Harry T Papaconstantinou, Fragiska Sigala, Georgios Zografos, Konstantinos Filis
Lower limb ischemia in diabetic patients is a result of macro- and microcirculation dysfunction. Diabetic patients undergoing limb amputation carry high mortality and morbidity rates, and decision making concerning the level of amputation is critical. Aim of this study is to evaluate a novel microdialysis technique to monitor tissue microcirculation preoperatively and predict the success of limb amputation in such patients. Overall, 165 patients with type 2 diabetes mellitus undergoing lower limb amputation were enrolled...
November 2016: Wound Repair and Regeneration
Lampros Liasis, Harry T Papaconstantinou
External hemorrhoidal skin tags are generally benign. Colorectal cancer metastases to the squamous epithelium of perianal skin tags without other evidence of disseminated disease is a very rare finding. We present the case of a 61-year-old man with metastasis to an external hemorrhoidal skin tag from a midrectal primary adenocarcinoma. This case report highlights the importance of close examination of the anus during surgical planning for colorectal cancers. Abnormal findings of the perianal skin suggesting an implant or metastatic disease warrant biopsy, as distal spread and seeding can occur...
April 2016: Proceedings of the Baylor University Medical Center
Monika-Filitsa Xenikou, Spyretta Golemati, Aimilia Gastounioti, Marianna Tzortzi, Nektarios Moraitis, Georgios Charalampopulos, Nicolaos Liasis, Athanasios Dedes, Nicolaos Besias, Konstantina S Nikita
Valid characterization of carotid atherosclerosis (CA) is a crucial public health issue, which would limit the major risk held by CA for both patient safety and state economies. CA is typically diagnosed and assessed using duplex ultrasonography (US). Elastrography Imaging (EI) is a promising US technique for quantifying tissue elasticity (ES). In this work, we investigated the association between ES of carotid atherosclerotic lesions, derived from EI, and texture indices, calculated from US image analysis...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
S Bokhari, M Kulendran, L Liasis, K Qurashi, M Sen, S Gould
INTRODUCTION: Emergency surgery is changing rapidly with a greater workload, early subspecialisation and centralisation of emergency care. We describe the impact of a novel emergency surgical unit (ESU) on the definitive management of patients with gallstone pancreatitis (GSP). METHODS: A comparative audit was undertaken for all admissions with GSP before and after the introduction of the ESU over a six-month period. The impact on compliance with British Society of Gastroenterology (BSG) guidelines was assessed...
May 2015: Annals of the Royal College of Surgeons of England
Niichiro Abe, Katsuki Matsubara, Kenichi Tamukai, Yasutsugu Miwa, Kazutoshi Takami
Sarcocystis nesbitti, using snakes as the definitive host, is a causative agent of acute human muscular sarcocystosis in Malaysia. Therefore, it is important to explore the distribution and prevalence of S. nesbitti in snakes. Nevertheless, epizootiological information of S. nesbitti in snakes remains insufficient because few surveys have assessed Sarcocystis infection in snakes in endemic countries. In Japan, snakes are popular exotic pet animals that are imported from overseas, but the degree of Sarcocystis infection in them remains unclear...
August 2015: Parasitology Research
Robert Zivadinov, Stefano Bastianello, Michael D Dake, Hector Ferral, E Mark Haacke, Ziv J Haskal, David Hubbard, Nikolaos Liasis, Kenneth Mandato, Salvatore Sclafani, Adnan H Siddiqui, Marian Simka, Paolo Zamboni
Under the auspices of the International Society for Neurovascular Disease (ISNVD), four expert panel committees were created from the ISNVD membership between 2011 and 2012 to determine and standardize noninvasive and invasive imaging protocols for detection of extracranial venous abnormalities indicative of chronic cerebrospinal venous insufficiency (CCSVI). The committees created working groups on color Doppler ultrasound (US), magnetic resonance (MR) imaging, catheter venography (CV), and intravascular US...
November 2014: Journal of Vascular and Interventional Radiology: JVIR
Akash Kumar, Max Dougherty, Gregory M Findlay, Madeleine Geisheker, Jason Klein, John Lazar, Heather Machkovech, Jesse Resnick, Rebecca Resnick, Alexander I Salter, Faezeh Talebi-Liasi, Christopher Arakawa, Jacob Baudin, Andrew Bogaard, Rebecca Salesky, Qian Zhou, Kelly Smith, John I Clark, Jay Shendure, Marshall S Horwitz
Even in cases where there is no obvious family history of disease, genome sequencing may contribute to clinical diagnosis and management. Clinical application of the genome has not yet become routine, however, in part because physicians are still learning how best to utilize such information. As an educational research exercise performed in conjunction with our medical school human anatomy course, we explored the potential utility of determining the whole genome sequence of a patient who had died following a clinical diagnosis of idiopathic pulmonary fibrosis (IPF)...
2014: PloS One
Daniel Kelberman, Lily Islam, Jörn Lakowski, Chiara Bacchelli, Estelle Chanudet, Francesco Lescai, Aara Patel, Elia Stupka, Anja Buck, Stephan Wolf, Philip L Beales, Thomas S Jacques, Maria Bitner-Glindzicz, Alki Liasis, Ordan J Lehmann, Jürgen Kohlhase, Ken K Nischal, Jane C Sowden
Ocular coloboma is a congenital defect resulting from failure of normal closure of the optic fissure during embryonic eye development. This birth defect causes childhood blindness worldwide, yet the genetic etiology is poorly understood. Here, we identified a novel homozygous mutation in the SALL2 gene in members of a consanguineous family affected with non-syndromic ocular coloboma variably affecting the iris and retina. This mutation, c.85G>T, introduces a premature termination codon (p.Glu29*) predicted to truncate the SALL2 protein so that it lacks three clusters of zinc-finger motifs that are essential for DNA-binding activity...
May 15, 2014: Human Molecular Genetics
R Graham Reynolds, Matthew L Niemiller, Liam J Revell
Snakes in the families Boidae and Pythonidae constitute some of the most spectacular reptiles and comprise an enormous diversity of morphology, behavior, and ecology. While many species of boas and pythons are familiar, taxonomy and evolutionary relationships within these families remain contentious and fluid. A major effort in evolutionary and conservation biology is to assemble a comprehensive Tree-of-Life, or a macro-scale phylogenetic hypothesis, for all known life on Earth. No previously published study has produced a species-level molecular phylogeny for more than 61% of boa species or 65% of python species...
February 2014: Molecular Phylogenetics and Evolution
Maria Tsimpida, Dorothy A Thompson, Alki Liasis, Vicki Smith, Judith E Kingston, Mandeep S Sagoo, M Ashwin Reddy
BACKGROUND/AIMS: To determine the frequency and cause of visual loss following intra-arterial melphalan (IAM) in patients with retinoblastoma with age appropriate vision. METHODS: Assessment of patients with refractory retinoblastoma that had undergone systemic chemotherapy, with or without local treatment, and were subsequently treated with IAM. Eyes of patients with a healthy foveola were assessed. The main outcome measures included visual, macular (including Pattern Visual Evoked Potentials and Fundus Fluorescein Angiography) and retinal functions (Electroretinograms)...
November 2013: British Journal of Ophthalmology
Lampros Liasis, Ioannis Tierris, Fotini Lazarioti, Clarence C Clark, Harry T Papaconstantinou
No abstract text is available yet for this article.
April 2013: Journal of Trauma and Acute Care Surgery
Dorothy A Thompson, Ruth J Lyons, Isabelle Russell-Eggitt, Alki Liasis, Herbert Jägle, Stephanie Grünewald
The congenital disorder of glycosylation, PMM2-CDG, is associated with progressive photoreceptor degeneration, which causes a pigmentary retinopathy. We identified a sibling pair, mildly affected with PMM2-CDG, who showed preserved photoreceptor function, but profound deficits of the 'on-pathway' in the retina. This localises the site of early, or initial, retinal dysfunction in PMM2-CDG to the synapse in the outer plexiform layer between bipolar cells, photoreceptors and horizontal cells. We sought wider evidence to support this novel finding by reviewing retrospectively the case notes of eight patients, diagnosed with PMM2-CDG between the ages of 7 months to 16 years...
November 2013: Journal of Inherited Metabolic Disease
Dorothy A Thompson, Ruth J Lyons, Alki Liasis, Isabelle Russell-Eggitt, Herbert Jägle, Stephanie Grünewald
OBJECTIVE: To describe novel electroretinographic (ERG) findings associated with congenital disorder of glycosylation due to phosphomannomutase deficiency (PMM2-CDG) (previously known as congenital disorder of glycosylation type 1a). METHODS: Two male siblings with genetically confirmed PMM2-CDG underwent full-field ERG to a range of scotopic and photopic flash luminances that extended the International Society for Clinical Electrophysiology of Vision standard protocol and included scotopic 15-Hz flicker and photopic prolonged on-off stimulation...
June 2012: Archives of Ophthalmology
Vasileios Vasilakis, Clarence E Clark, Lampros Liasis, Harry T Papaconstantinou
BACKGROUND: Single-incision laparoscopic (SIL) colectomy has gained significant momentum with anticipated benefit of improved cosmesis. Feasibility and safety of SIL colectomy have been shown; however, benefits are not well defined. The purpose of this study is to directly compare outcomes of SIL sigmoid colectomy for diverticular disease with standard multiport laparoscopic (LAP) technique. METHODS: SIL sigmoid colectomy cases performed for diverticular disease between August 2009 and July 2011 were case matched for age, gender, body mass index, American Society of Anesthesiologists score, previous abdominal operation, and need to mobilize the splenic flexure and compared with an equal number of LAP cases...
April 2013: Journal of Surgical Research
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