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JOURNAL ARTICLE
Noriyuki Naya, Toshinaga Tsuji, Nobuhiro Nishigaki, Chika Sakai, Yirong Chen, Sungeun Jung, Hirotaka Kosaka
Background Symptoms experienced by adult patients with attention-deficit/hyperactivity disorder (ADHD) frequently result in functional impairment across academic/occupational functioning, daily life, and social functioning. A substantial proportion of undiagnosed and untreated ADHD has been suggested in Japan. This study aims to better understand the potential undiagnosed ADHD population in Japan by quantifying the burden associated with ADHD symptoms through a comparison of the prevalence of comorbidities, health-related quality of life (HRQoL), work productivity and activity impairment (WPAI), and healthcare resource utilization (HRU) between undiagnosed potential ADHD respondents who were screened positive and negative using Adult ADHD Self-Report Scale (ASRS)-v1...
November 2021: Curēus
#22
JOURNAL ARTICLE
Claudia L Reardon
Athletes at all levels of competition are susceptible to mental health symptoms and disorders, and this has been a topic of increased research attention in recent years. The most common such conditions will be highlighted in this article, with a clinical focus on unique aspects of presentation, diagnosis, and management among athletes. Conditions addressed include depression, anxiety and related disorders, eating disorders, sleep concerns, attention-deficit/hyperactivity disorder, bipolar and psychotic disorders, and substance use disorders and behavioral addictions...
December 1, 2021: Current Sports Medicine Reports
#23
REVIEW
Subhabrata Paul, Shreya Chakraborty, Uttpal Anand, Swarnali Dey, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Manoj Tukaram Patil, Ramesh Kandimalla, Jarosław Proćków, Abhijit Dey
Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative properties against a plethora of human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents. In addition, it presents a detailed account of its presence as an active constituent in many commercial preparations with curative properties and health benefits...
November 2021: Biomedicine & Pharmacotherapy
#24
JOURNAL ARTICLE
H Javelot, C Straczek, G Meyer, C Gitahy Falcao Faria, L Weiner, D Drapier, E Fakra, P Fossati, S Weibel, S Dizet, B Langrée, M Masson, R Gaillard, M Leboyer, P M Llorca, C Hingray, E Haffen, A Yrondi
The use of psychotropics during the COVID-19 pandemic has raised two questions, in order of importance: first, what changes should be made to pharmacological treatments prescribed to mental health patients? Secondly, are there any positive side effects of these substances against SARS-CoV-2? Our aim was to analyze usage safety of psychotropics during COVID-19; therefore, herein, we have studied: (i) the risk of symptomatic complications of COVID-19 associated with the use of these drugs, notably central nervous system activity depression, QTc interval enlargement and infectious and thromboembolic complications; (ii) the risk of mistaking the iatrogenic impact of psychotropics with COVID-19 symptoms, causing diagnostic error...
September 2, 2021: L'Encéphale
#25
JOURNAL ARTICLE
Adam Langenfeld, Maria Kroupina, Alyssa Palmer, Kimara Gustafson, Marilyn Augustyn
As part of a multidisciplinary adoption support clinic, Erin, a 5-year-old girl, adopted approximately 6 months before the clinic visit, presents for postadoption evaluation. Erin was born at full term. Her birth history was significant for reported maternal treatment for liver failure during pregnancy. Her previous medical history included hospitalization for a viral illness at age 2 months, recurrent ear infections, and a fractured forearm. Family history was significant for a maternal history of bipolar disorder, depression, anxiety, borderline personality disorder, and concern for substance abuse; a paternal history of attention-deficit/hyperactivity disorder (ADHD) and depression; and full biological brother with a history of ADHD and oppositional defiant disorder...
October 2021: Journal of Developmental and Behavioral Pediatrics: JDBP
#26
JOURNAL ARTICLE
Anne Duffy
No abstract text is available yet for this article.
July 26, 2021: Bipolar Disorders
#27
REVIEW
P V Moskaleva, N A Shnayder, R F Nasyrova
Melatonin is the most well-known regulator of the circadian rhythms of all living organisms and the main substrate synthesized at night. There are 4 stages in the synthesis of melatonin. This review focuses on the 2nd, 3rd, and 4th stages. The review is aimed at analyzing publications on molecular genetic association studies on the role of single nucleotide polymorphisms (SNPs) of the DDC ( AADC ), AANAT and ASMT genes encoding melatonin synthesis enzymes in the pathogenesis of socially significant neuropsychiatric disorders in humans...
2021: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#28
JOURNAL ARTICLE
Steinn Steingrímsson, Ellen Odéus, Mats Cederlund, Stefan Franzén, Carina Helgesson, Kristina Nyström, John Sondell, Arve Opheim
OBJECTIVE: To measure rate of subscription of common sleep medication and diagnoses of substance use disorder (SUD) before and after receiving a prescribed weighted blanket (WB) among patients with psychiatric diagnoses. MATERIALS AND METHODS: Using register-based data of health-related factors in a Swedish region, a total of 1785 adult individuals with a psychiatric diagnosis, received a WB and resided in the region during the study period were identified. Using each individual as their own control, the rate of one-year prior prescription of WB or diagnosed SUD was compared to rate after a half year wash-out after prescription of WB for a full year...
January 2022: Nordic Journal of Psychiatry
#29
JOURNAL ARTICLE
Kazutaka Ohi, Ryo Ochi, Yoshihiro Noda, Masataka Wada, Shunsuke Sugiyama, Akira Nishi, Toshiki Shioiri, Masaru Mimura, Shinichiro Nakajima
Sleep disturbance is a common symptom of psychiatric and neurodevelopmental disorders and, especially in childhood, can be a precursor to various mental disorders. However, the genetic etiology of mental illness that contributes to sleep disturbance during childhood is poorly understood. We investigated whether the polygenic features of psychiatric and neurodevelopmental disorders are associated with sleep disturbance during childhood. We conducted polygenic risk score (PRS) analyses by utilizing large-scale genome-wide association studies (GWASs) (n = 46,350-500,199) of five major psychiatric and neurodevelopmental disorders (autism spectrum disorder, schizophrenia, attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and bipolar disorder) and, additionally, anxiety disorders as base datasets...
March 26, 2021: Translational Psychiatry
#30
JOURNAL ARTICLE
Charlotte A Dennison, Sophie E Legge, Matthew Bracher-Smith, Georgina Menzies, Valentina Escott-Price, Daniel J Smith, Aiden R Doherty, Michael J Owen, Michael C O'Donovan, James T R Walters
Levels of activity are often affected in psychiatric disorders and can be core symptoms of illness. Advances in technology now allow the accurate assessment of activity levels but it remains unclear whether alterations in activity arise from shared risk factors for developing psychiatric disorders, such as genetics, or are better explained as consequences of the disorders and their associated factors. We aimed to examine objectively-measured physical activity in individuals with psychiatric disorders, and assess the role of genetic liability for psychiatric disorders on physical activity...
2021: PloS One
#31
JOURNAL ARTICLE
Santiago Estrada-Jaramillo, Claudia Patricia Quintero-Cadavid, Rommel Andrade-Carrillo, Sujey Gómez-Cano, Juan Jose Eraso-Osorio, Juan Pablo Zapata-Ospina, Daniel Camilo Aguirre-Acevedo, Johanna Valencia-Echeverry, Carlos López-Jaramillo, Juan David Palacio-Ortiz
INTRODUCTION: The offspring of bipolar parents (BO) is a high-risk population for inheriting the bipolar disorder (BD) and other early clinical manifestations, such as sleep disturbances. OBJECTIVE: To compare the presence of psychiatric disorders and sleep disturbances of BO versus offspring of control parents (OCP). METHODS: A cross-sectional analytical study was conducted that compared BO versus OCP. The participants were assessed using valid tools to determine the presence of psychiatric symptoms or disorders...
August 13, 2020: Revista Colombiana de Psiquiatría
#32
JOURNAL ARTICLE
Alessandro Pallucchini, Marco Carli, Marco Scarselli, Icro Maremmani, Giulio Perugi
A large amount of the current literature has focused on the characteristic symptoms of attention deficit hyperactivity disorder (ADHD) in children and adolescents. In contrast, less attention has been devoted to ADHD clinical subtypes in adult patients. We evaluated 164 consecutive adult ADHD (A-ADHD) outpatients using DSM-5 criteria and many specific rating scales and questionnaires. A principal component factor analysis was performed on clinical and symptomatological variables to describe potential clinical variants...
January 21, 2021: International Journal of Environmental Research and Public Health
#33
JOURNAL ARTICLE
Natchanan Charatcharungkiat, Joan Luby, Rebecca Tillman, Alecia Vogel
OBJECTIVES: First, to investigate whether specific manic symptoms in preschool predict manic symptom severity in adolescence. Second, to investigate the interaction between family history (FH) of bipolar disorder (BP) and preschool manic symptoms in predicting later adolescent manic symptom severity. METHODS: This analysis utilized data from the Preschool Depression Study (PDS) which followed 306 preschoolers aged 3-6 years over time since 2003. Only subjects that had data both at baseline (age 3-6 years) and at or after age 12 were included (n=122)...
January 15, 2021: Bipolar Disorders
#34
JOURNAL ARTICLE
Silvia Biere, Thorsten M Kranz, Silke Matura, Kristiyana Petrova, Fabian Streit, Andreas G Chiocchetti, Oliver Grimm, Murielle Brum, Natalie Brunkhorst-Kanaan, Viola Oertel, Aliaksandr Malyshau, Andrea Pfennig, Michael Bauer, Thomas G Schulze, Sarah Kittel-Schneider, Andreas Reif
Objective: Identifying high-risk groups with an increased genetic liability for bipolar disorder (BD) will provide insights into the etiology of BD and contribute to early detection of BD. We used the BD polygenic risk score (PRS) derived from BD genome-wide association studies (GWAS) to explore how such genetic risk manifests in young, high-risk adults. We postulated that BD-PRS would be associated with risk factors for BD. Methods: A final sample of 185 young, high-risk German adults (aged 18-35 years) were grouped into three risk groups and compared to a healthy control group ( n = 1,100)...
2020: Frontiers in Psychiatry
#35
JOURNAL ARTICLE
Patrick E Link
No abstract text is available yet for this article.
May 2021: Bipolar Disorders
#36
JOURNAL ARTICLE
Joseph Firth, Marco Solmi, Robyn E Wootton, Davy Vancampfort, Felipe B Schuch, Erin Hoare, Simon Gilbody, John Torous, Scott B Teasdale, Sarah E Jackson, Lee Smith, Melissa Eaton, Felice N Jacka, Nicola Veronese, Wolfgang Marx, Garcia Ashdown-Franks, Dan Siskind, Jerome Sarris, Simon Rosenbaum, André F Carvalho, Brendon Stubbs
There is increasing academic and clinical interest in how "lifestyle factors" traditionally associated with physical health may also relate to mental health and psychological well-being. In response, international and national health bodies are producing guidelines to address health behaviors in the prevention and treatment of mental illness. However, the current evidence for the causal role of lifestyle factors in the onset and prognosis of mental disorders is unclear. We performed a systematic meta-review of the top-tier evidence examining how physical activity, sleep, dietary patterns and tobacco smoking impact on the risk and treatment outcomes across a range of mental disorders...
October 2020: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
#37
RANDOMIZED CONTROLLED TRIAL
Bodil Ekholm, Stefan Spulber, Mats Adler
STUDY OBJECTIVES: This study aimed to evaluate the effect of weighted chain blankets on insomnia and sleep-related daytime symptoms for patients with major depressive disorder, bipolar disorder, generalized anxiety disorder, and attention deficit hyperactivity disorder. METHODS: One hundred twenty patients were randomized (1:1) to either a weighted metal chain blanket or a light plastic chain blanket for 4 weeks. The outcome was evaluated using the Insomnia Severity Index as primary outcome measure and day and night diaries, Fatigue Symptom Inventory, and Hospital Anxiety and Depression Scale as secondary outcome measures...
September 15, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#38
REVIEW
A Duffy, G Carlson, B Dubicka, M H J Hillegers
BACKGROUND: Evidence from epidemiological, clinical and high-risk studies has established that the peak period of risk for onset of bipolar disorder spans late adolescence and early adulthood. However, the proposal of the existence of a pre-pubertal form of bipolar disorder manifesting in early childhood created substantial debate. In this narrative review, the literature and contributing factors pertaining to the controversy surrounding the proposed pre-pubertal bipolar disorder subtype are discussed...
April 20, 2020: International Journal of Bipolar Disorders
#39
REVIEW
Sarah Kittel-Schneider, Andreas Reif
All large population-based administrative studies currently indicate a significant comorbidity of adult attention deficit hyperactivity disorder (ADHD) with addictive, anxiety and in particular affective disorders. In these investigations the risk for one of these comorbid disorders increased with increasing age of the ADHD patients. The most recent genome-wide association and correlation studies also revealed indications for joint genetic risk factors of ADHD with, in particular unipolar depression, bipolar disorder, autism spectrum disorders, Tourette's syndrome and to a lesser extent schizophrenia...
July 2020: Der Nervenarzt
#40
REVIEW
Paul M Thompson, Neda Jahanshad, Christopher R K Ching, Lauren E Salminen, Sophia I Thomopoulos, Joanna Bright, Bernhard T Baune, Sara Bertolín, Janita Bralten, Willem B Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G F de Kovel, Gary Donohoe, Lisa T Eyler, Stephen V Faraone, Pauline Favre, Courtney A Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J Grabe, Katrina L Grasby, Tomas Hajek, Laura K M Han, Sean N Hatton, Kevin Hilbert, Tiffany C Ho, Laurena Holleran, Georg Homuth, Norbert Hosten, Josselin Houenou, Iliyan Ivanov, Tianye Jia, Sinead Kelly, Marieke Klein, Jun Soo Kwon, Max A Laansma, Jeanne Leerssen, Ulrike Lueken, Abraham Nunes, Joseph O' Neill, Nils Opel, Fabrizio Piras, Federica Piras, Merel C Postema, Elena Pozzi, Natalia Shatokhina, Carles Soriano-Mas, Gianfranco Spalletta, Daqiang Sun, Alexander Teumer, Amanda K Tilot, Leonardo Tozzi, Celia van der Merwe, Eus J W Van Someren, Guido A van Wingen, Henry Völzke, Esther Walton, Lei Wang, Anderson M Winkler, Katharina Wittfeld, Margaret J Wright, Je-Yeon Yun, Guohao Zhang, Yanli Zhang-James, Bhim M Adhikari, Ingrid Agartz, Moji Aghajani, André Aleman, Robert R Althoff, Andre Altmann, Ole A Andreassen, David A Baron, Brenda L Bartnik-Olson, Janna Marie Bas-Hoogendam, Arielle R Baskin-Sommers, Carrie E Bearden, Laura A Berner, Premika S W Boedhoe, Rachel M Brouwer, Jan K Buitelaar, Karen Caeyenberghs, Charlotte A M Cecil, Ronald A Cohen, James H Cole, Patricia J Conrod, Stephane A De Brito, Sonja M C de Zwarte, Emily L Dennis, Sylvane Desrivieres, Danai Dima, Stefan Ehrlich, Carrie Esopenko, Graeme Fairchild, Simon E Fisher, Jean-Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Hugh P Garavan, David C Glahn, Nynke A Groenewold, Tiril P Gurholt, Boris A Gutman, Tim Hahn, Ian H Harding, Dennis Hernaus, Derrek P Hibar, Frank G Hillary, Martine Hoogman, Hilleke E Hulshoff Pol, Maria Jalbrzikowski, George A Karkashadze, Eduard T Klapwijk, Rebecca C Knickmeyer, Peter Kochunov, Inga K Koerte, Xiang-Zhen Kong, Sook-Lei Liew, Alexander P Lin, Mark W Logue, Eileen Luders, Fabio Macciardi, Scott Mackey, Andrew R Mayer, Carrie R McDonald, Agnes B McMahon, Sarah E Medland, Gemma Modinos, Rajendra A Morey, Sven C Mueller, Pratik Mukherjee, Leyla Namazova-Baranova, Talia M Nir, Alexander Olsen, Peristera Paschou, Daniel S Pine, Fabrizio Pizzagalli, Miguel E Rentería, Jonathan D Rohrer, Philipp G Sämann, Lianne Schmaal, Gunter Schumann, Mark S Shiroishi, Sanjay M Sisodiya, Dirk J A Smit, Ida E Sønderby, Dan J Stein, Jason L Stein, Masoud Tahmasian, David F Tate, Jessica A Turner, Odile A van den Heuvel, Nic J A van der Wee, Ysbrand D van der Werf, Theo G M van Erp, Neeltje E M van Haren, Daan van Rooij, Laura S van Velzen, Ilya M Veer, Dick J Veltman, Julio E Villalon-Reina, Henrik Walter, Christopher D Whelan, Elisabeth A Wilde, Mojtaba Zarei, Vladimir Zelman
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics...
March 20, 2020: Translational Psychiatry
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