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hypothermia chemotherapy in lung cancer

Nozomi Ami, Hideki Sato, Yoshihiro Hayakawa
Housing temperature has been shown to influence thermoregulation and behavior of preclinical cancer models; and anti-cancer drugs typically reduce peripheral blood flow and body temperature. In the present study, the effects of paclitaxel (PTX)-induced reduction of body temperature and peripheral blood flow on metastatic 4T1 breast cancer was investigated in a mouse model and the modification of these effects by thermoneutral temperature was also assessed. A single dose of PTX decreased the body temperature and peripheral blood flow in mice housed at a standard temperature (23°C)...
February 2018: Oncology Letters
L H Iversen, P C Rasmussen, R Hagemann-Madsen, S Laurberg
AIM: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option with curative intent for selected patients with peritoneal carcinomatosis (PC). CRS and HIPEC have been implemented in Denmark at a single centre since 2006. Six years of data on these patients were analysed. METHOD: Patients with PC from colorectal or appendiceal cancer, pseudomyxoma peritonei or malignant peritoneal mesothelioma referred to the single national HIPEC centre were prospectively registered from June 2006 to July 2012...
July 2013: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Junzo Shimizu, Chikako Ikeda, Yoshihiko Arano, Iwao Adachi, Minoru Morishita, Shojiro Yamaguchi, Norihiko Ishikawa, Go Watanabe, Hiroshi Minato
A 68-year-old man presented with a chief complaint being a cough. Based on a bronchoscopic biopsy, it was diagnosed at a nearby clinic as an advanced left lung cancer, and he was referred to our hospital. Chest computed tomography (CT) scans demonstrated a giant mass of the left lower lobe, 14 × 12 cm in size, which appeared to have invaded the left atrium (LA). The operation was started with double vena cava cannulation via the right internal jugular vein and the right femoral vein as well as arterial cannulation via the right femoral artery...
August 2010: Annals of Thoracic and Cardiovascular Surgery
K Miyagi, T Yamazaki, I Tsujino, N Takahashi, Y Koya, M Masutani, U Sawada, T Horie
Autologous stem cell transplantation is used widely after high-dose chemotherapy for treating hematological and other malignancies. Bone marrow harvested for autologous bone marrow transplantation may contain residual malignant cells even when the cancer is judged to be in remission. Attempts to purge marrow of its putative residual malignant cells may delay hemopoietic reconstitution and are of uncertain efficacy. In this report, we demonstrate the possibility of applying hypothermia to autologous stem cell purging...
May 2001: Cryobiology
R Komaki, N A Janjan, J A Ajani, P M Lynch, J S Fairweather, I Raijman, G R Blumenshein, L Ho, P W Pisters, B W Feig, G L Walsh, R Pazdur
Irinotecan (Camptosar) is an active chemotherapeutic agent for lung, gastric, esophageal, and colorectal cancers and a potent radiosensitizer. This phase I study was designed to assess the maximum tolerated dose of weekly irinotecan combined with concurrent radiotherapy for patients with locally advanced, unresectable gastric, gastroesophageal junction, or esophageal cancer. Patients who received previous chemotherapy (excluding irinotecan) or who experienced recurrent cancer after surgery were eligible for this protocol...
December 2000: Oncology (Williston Park, NY)
T Sakaeda, K Fukumura, K Takahashi, S Matsumura, E Matsuura, K Hirano
The blood flow rates of 14 tissues in the body were determined by microsphere method using normal and tumor-bearing rats kept conscious or under urethane anesthesia. The effects on the blood flow rate in the tissues were assessed for multimodal therapy, systemic hypothermia for ischemic brain injury, and local hyperthermia and angiotensin II-induced hypertensive chemotherapy for cancer. Urethane anesthesia showed no effect on cardiac output, while there was a tendency of decrease of blood flow rate and % of cardiac output in each tissue other than muscle tissue, in which they increased as a counterbalance, in normal and tumor-bearing rats...
1998: Journal of Drug Targeting
V P Popovic, I Kostolny, J H Larose, D Novicic, J E Baughman, K A Pass, P Popovic, C Robinzine, F Gollan
No abstract text is available yet for this article.
May 1971: Journal de Physiologie
R E Weishaar, M H Cain, J A Bristol
With several notable exceptions, interest in the area of multiple molecular forms of phosphodiesterase remained relatively dormant during the decade following Thompson's discovery of more than one phosphodiesterase in brain in 1971. Within the last several years, however, over 20 novel agents have been identified that exert selective inhibitory effects on the various molecular forms of phosphodiesterase present within different cells. In addition, several studies have documented that such agents can produce discrete changes in cyclic AMP and cyclic GMP, an action that is not shared by "first generation" phosphodiesterase inhibitors such as theophylline...
May 1985: Journal of Medicinal Chemistry
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