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Breast cancer, MRI

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https://www.readbyqxmd.com/read/28332033/surgeon-attitudes-and-use-of-mri-in-patients-newly-diagnosed-with-breast-cancer
#1
Monica Morrow, Sarah T Hawley, M Chandler McLeod, Ann S Hamilton, Kevin C Ward, Steven J Katz, Reshma Jagsi
BACKGROUND: Usage of magnetic resonance imaging (MRI) in newly diagnosed breast cancer patients is increasing, despite scant evidence that it improves outcomes. Little is known about the knowledge, perspectives, and clinical characteristics of surgeons associated with MRI use. METHODS: Women with early-stage breast cancer undergoing definitive surgery between July 2013 and August 2015 were identified from the Los Angeles and Georgia Surveillance, Epidemiology and End Results (SEER) registries and were asked to name their attending surgeons...
March 22, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28331765/background-parenchymal-enhancement-and-fibroglandular-tissue-proportion-on-breast-mri-correlation-with-hormone-receptor-expression-and-molecular-subtypes-of-breast-cancer
#2
Mesut Öztürk, Ahmet Veysel Polat, Yurdanur Süllü, Leman Tomak, Ayfer Kamalı Polat
OBJECTIVE: To assess the relationship between background parenchymal enhancement (BPE) and fibroglandular tissue (FGT) proportion on breast magnetic resonance imaging (MRI) and hormone receptor expression and molecular subtypes in invasive breast cancer. MATERIALS AND METHODS: This retrospective study enrolled 75 breast cancer patients who underwent breast MRI before treatment. T1-weighted images were reviewed to determine the FGT proportion, and contrast-enhanced fat-suppressed T1-weighted images were reviewed to determine BPE...
January 2017: J Breast Health (2013)
https://www.readbyqxmd.com/read/28325260/imaging-performance-in-guiding-response-to-neoadjuvant-therapy-according-to-breast-cancer-subtypes-a-systematic-literature-review
#3
REVIEW
Melanie A Lindenberg, Anna Miquel-Cases, Valesca P Retèl, Gabe S Sonke, Jelle Wesseling, Marcel P M Stokkel, Wim H van Harten
Monitoring therapeutic response to neoadjuvant chemotherapy(NAC) is likely to improve NAC effectiveness in breast cancer(BC). Imaging performance seems to vary per tumour subtype(by ER and HER2 status), therefore we performed a systematic review on subtype specific imaging performance in monitoring NAC in BC. Studies examining imaging performance in predicting pathologic complete response(pCR) during NAC in BC subtypes were selected. Per study, negative- and positive predictive value, sensitivity(se) and specificity(sp), AUC and accuracy were derived...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28323572/bilateral-changes-in-deep-tissue-environment-after-manual-lymphatic-drainage-in-patients-with-breast-cancer-treatment-related-lymphedema
#4
Paula M C Donahue, Rachelle Crescenzi, Allison O Scott, Vaughn Braxton, Aditi Desai, Seth A Smith, John Jordi, Ingrid M Meszoely, Ana M Grau, Rondi M Kauffmann, Raeshell S Sweeting, Kandace Spotanski, Sheila H Ridner, Manus J Donahue
BACKGROUND: Breast cancer treatment-related lymphedema (BCRL) arises from a mechanical insufficiency following cancer therapies. Early BCRL detection and personalized intervention require an improved understanding of the physiological processes that initiate lymphatic impairment. Here, internal magnetic resonance imaging (MRI) measures of the tissue microenvironment were paired with clinical measures of tissue structure to test fundamental hypotheses regarding structural tissue and muscle changes after the commonly used therapeutic intervention of manual lymphatic drainage (MLD)...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28321344/pituitary-adenoma-and-hyperprolactinemia-accompanied-by-idiopathic-granulomatous-mastitis
#5
Sebahattin Destek, Vahit Onur Gul, Serkan Ahioglu, Kursat Rahmi Serin
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of the breast, and its etiology remains not fully elucidated. IGM is observed more often in patients with autoimmune disease. Hyperprolactinemia is observed during pregnancy, lactation, and a history of oral contraceptive use. A 39-year-old patient with no history of oral contraceptive use presented with complaints such as redness, pain, and swelling in her left breast. Ultrasound and magnetic resonance imaging (MRI) revealed a suspicious inflamed mass lesion...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28318506/assessment-of-disease-extent-on-contrast-enhanced-mri-in-breast-cancer-detected%C3%A2-at-digital-breast-tomosynthesis-versus%C3%A2-digital-mammography-alone
#6
A V Chudgar, E F Conant, S P Weinstein, B M Keller, M Synnestvedt, P Yamartino, E S McDonald
AIM: To compare the utility of breast magnetic resonance imaging (MRI) in determining the extent of disease in patients with newly diagnosed breast cancer detected on combination digital breast tomosynthesis (DBT) versus digital screening mammography (DM). MATERIALS AND METHODS: Review of 24,563 DBT-screened patients and 10,751 DM-screened patients was performed. Two hundred and thirty-five DBT patients underwent subsequent MRI examinations; 82 to determine extent of disease after newly diagnosed breast cancer...
March 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28315967/relationship-of-breast-mri-to-recurrence-rates-in-patients-undergoing-breast-conservation-treatment
#7
Maureen V Hill, Julia L Beeman, Khushboo Jhala, Stefan D Holubar, Kari M Rosenkranz, Richard J Barth
PURPOSE: The effect of pre-operative MRI on the in-breast tumor recurrence rate (IBTR) of patients undergoing breast-conservation treatment (BCT) remains uncertain. We began to routinely perform pre-operative MRI in 2006. Our goal was to determine the effect of pre-operative MRI on IBTR. METHODS: Retrospective review of a prospective database of all patients undergoing BCT (n = 1396) from 2000 to 2010. IBTR were calculated using Kaplan-Meier estimates. RESULTS: 664 (47...
March 18, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28315905/breast-specific-gamma-camera-imaging-with-99m-tc-mibi-has-better-diagnostic-performance-than-magnetic-resonance-imaging-in-breast-cancer-patients-a-meta-analysis
#8
Aimi Zhang, Panli Li, Qiufang Liu, Shaoli Song
OBJECTIVE: This study aimed to evaluate the diagnostic role of breast-specific gamma camera imaging (BSGI) with technetium-99m-methoxy isobutyl isonitrile ((99m)Tc-MIBI) and magnetic resonance imaging (MRI) in patients with breast cancer through a meta-analysis. METHODS: Three reviewers searched articles published in medical journals before June 2016 in MEDLINE, EMBASE and Springer Databases; the references listed in original articles were also retrieved. We used the quality assessment of diagnostic accuracy studies (QUADAS) tool to assess the quality of the included studies...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28314588/risk-of-breast-cancer-after-a-diagnosis-of-ovarian-cancer-in-brca-mutation-carriers-is-preventive-mastectomy-warranted
#9
Jacob McGee, Vasily Giannakeas, Beth Karlan, Jan Lubinski, Jacek Gronwald, Barry Rosen, John McLaughlin, Harvey Risch, Ping Sun, William D Foulkes, Susan L Neuhausen, Joanne Kotsopoulos, Steven A Narod
OBJECTIVE: Preventive breast surgery and MRI screening are offered to unaffected BRCA mutation carriers. The clinical benefit of these two modalities has not been evaluated among mutation carriers with a history of ovarian cancer. Thus, we sought to determine whether or not BRCA mutation carriers with ovarian cancer would benefit from preventive mastectomy or from MRI screening. METHODS: First, the annual mortality rate for ovarian cancer patients was estimated for a cohort of 178 BRCA mutation carriers from Ontario, Canada...
March 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28314197/use-of-hepatobiliary-phase-images-in-gd-eob-dtpa-enhanced-mri-of-breast-cancer-hepatic-metastasis-to-predict-response-to-chemotherapy
#10
Hyun Ji Lee, Chang Hee Lee, Jeong Woo Kim, Yang Shin Park, Jongmee Lee, Kyeong Ah Kim
OBJECTIVES: To determine the prognostic value of Gd-EOB-DTPA MRI findings of liver metastasis from breast cancer. METHODS: 29 metastatic lesions from 12 breast cancer patients who received chemotherapy were retrospectively reviewed. We evaluated hepatobiliary phase of the lesions and classified them as a "target" or "non-target" appearance. The relationship of appearance or SI ratio with tumor response was analyzed. RESULTS: A non-target appearance was more frequent in disease control group than in non-control group [14/18 (77...
March 9, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28301933/ferritin-decorated-plga-paclitaxel-loaded-nanoparticles-endowed-with-an-enhanced-toxicity-towards-mcf-7-breast-tumour-cells
#11
Ludmila N Turino, Maria Ruggiero, Rachele Stefania, Juan Carlos Cutrin, Silvio Aime, Simonetta Geninatti Crich
PolyLactic and Glycolic Acid nanoparticles (PLGA-NPs), coated with L-Ferritin, are exploited for the simultaneous delivery of paclitaxel and an amphiphilic Gd based MRI contrast agent into breast cancer cells (MCF7). L-Ferritin has been covalently conjugated to the external surface of PLGA-NPs exploiting NHS activated carboxylic groups. The results confirmed that nanoparticles decorated with L-Ferritin have many advantages with respect both albumin-decorated and non-decorated particles. Ferritin moieties endow PLGA-NPs with targeting capability, exploiting SCARA5 receptors overexpressed by these tumour cells, that results in an increased paclitaxel cytotoxicity...
March 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28301207/second-opinion-review-of-breast-imaging-at-a-cancer-center-is-it-worthwhile
#12
Kristen Coffey, Donna D'Alessio, Delia M Keating, Elizabeth A Morris
OBJECTIVE: Second-opinion review of breast imaging studies can be a time-consuming and labor-intensive process. The purpose of this investigation was to determine whether reinterpretation of studies obtained at institutions outside a cancer center influences clinical management, specifically by revealing additional cancer and preventing unnecessary biopsy. MATERIALS AND METHODS: A review was conducted of breast imaging studies of 200 patients who underwent ultrasound and MRI at community facilities and had the images submitted for second opinions at a cancer center between January and April 2014...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28300372/lung-volume-reproducibility-under-abc-control-and-self-sustained-breath-holding
#13
Evangelia Kaza, Alex Dunlop, Rafal Panek, David J Collins, Matthew Orton, Richard Symonds-Tayler, Dualta McQuaid, Erica Scurr, Vibeke Hansen, Martin O Leach
An Active Breathing Coordinator (ABC) can be employed to induce breath-holds during CT imaging and radiotherapy of lung, breast and liver cancer, and recently during lung cancer MRI. The apparatus measures and controls respiratory volume, hence subject lung volume reproducibility is its principal measure of effectiveness. To assess ABC control quality, the intra-session reproducibility of ABC-induced lung volumes was evaluated and compared with that reached by applying the clinical standard of operator-guided self-sustained breath-holds on healthy volunteers during MRI...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297421/characteristics-of-quantitative-perfusion-parameters-on-dynamic-contrast-enhanced-mri-in-mammographically-occult-breast-cancer
#14
Jung Kyu Ryu, Sun Jung Rhee, Jeong Yoon Song, Soo Hyun Cho, Geon-Ho Jahng
The purpose of this study was to compare the characteristics of quantitative perfusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans,kep,ve,vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE-MRI data were acquired. Various prognostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, E-cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295860/relationships-between-mri-breast-imaging-reporting-and-data-system-bi-rads-lexicon-descriptors-and-breast-cancer-molecular-subtypes-internal-enhancement-is-associated-with-luminal-b-subtype
#15
Lars J Grimm, Jing Zhang, Jay A Baker, Mary S Soo, Karen S Johnson, Maciej A Mazurowski
The aim of this study was to determine the associations between breast MRI findings using the Breast Imaging-Reporting and Data System (BI-RADS) lexicon descriptors and breast cancer molecular subtypes. In this retrospective, IRB-approved, single institution study MRIs from 278 women with breast cancer were reviewed by one of six fellowship-trained breast imagers. Readers reported BI-RADS descriptors for breast masses (shape, margin, internal enhancement) and non-mass enhancement (distribution, internal enhancement)...
March 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28295818/accuracy-of-fully-automated-quantitative-volumetric-measurement-of-the-amount-of-fibroglandular-breast-tissue-using-mri-correlation-with-anthropomorphic-breast-phantoms
#16
Georg J Wengert, Katja Pinker, Thomas H Helbich, Wolf-Dieter Vogl, Sylvia M Spijker, Hubert Bickel, Stephan H Polanec, Pascal A Baltzer
To demonstrate the accuracy of fully automated, quantitative, volumetric measurement of the amount of fibroglandular breast tissue (FGT), using MRI, and to investigate the impact of different MRI sequences using anthropomorphic breast phantoms as the ground truth. In this study, 10 anthropomorphic breast phantoms that consisted of different known fractions of adipose and protein tissue, which closely resembled normal breast parenchyma, were developed. Anthropomorphic breast phantoms were imaged with a 1.5 T unit (Siemens, Avantofit) using an 18-channel breast coil...
March 10, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28293478/disrupted-brain-network-functional-dynamics-and-hyper-correlation-of-structural-and-functional-connectome-topology-in-patients-with-breast-cancer-prior-to-treatment
#17
Shelli R Kesler, Marjorie Adams, Melissa Packer, Vikram Rao, Ashley M Henneghan, Douglas W Blayney, Oxana Palesh
INTRODUCTION: Several previous studies have demonstrated that cancer chemotherapy is associated with brain injury and cognitive dysfunction. However, evidence suggests that cancer pathogenesis alone may play a role, even in non-CNS cancers. METHODS: Using a multimodal neuroimaging approach, we measured structural and functional connectome topology as well as functional network dynamics in newly diagnosed patients with breast cancer. Our study involved a novel, pretreatment assessment that occurred prior to the initiation of any cancer therapies, including surgery with anesthesia...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28290072/changes-in-brain-white-matter-integrity-after-systemic-treatment-for-breast-cancer-a-prospective-longitudinal-study
#18
Sanne Menning, Michiel B de Ruiter, Dick J Veltman, Willem Boogerd, Hester S A Oldenburg, Liesbeth Reneman, Sanne B Schagen
An increasing number of studies suggest chemotherapy for breast cancer may be neurotoxic. Cross-sectional MRI diffusion tensor imaging (DTI) studies suggest a vulnerability of brain white matter to various chemotherapeutic regimens. Up till now, this was confirmed in one prospective DTI study: Deprez et al. (2012) showed a widespread decline in fractional anisotropy (FA) of breast cancer patients after chemotherapy consisting of 5-fluorouracil (5-FU), epirubicin and cyclophosphamide (FEC) +/- taxanes +/- endocrine treatment...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28282591/a-novel-computer-aided-diagnosis-system-for-breast-mri-based-on-feature-selection-and-ensemble-learning
#19
Wei Lu, Zhe Li, Jinghui Chu
Breast cancer is a common cancer among women. With the development of modern medical science and information technology, medical imaging techniques have an increasingly important role in the early detection and diagnosis of breast cancer. In this paper, we propose an automated computer-aided diagnosis (CADx) framework for magnetic resonance imaging (MRI). The scheme consists of an ensemble of several machine learning-based techniques, including ensemble under-sampling (EUS) for imbalanced data processing, the Relief algorithm for feature selection, the subspace method for providing data diversity, and Adaboost for improving the performance of base classifiers...
March 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28275900/a-simple-classification-system-the-tree-flowchart-for-breast-mri-can-reduce-the-number-of-unnecessary-biopsies-in-mri-only-lesions
#20
Ramona Woitek, Claudio Spick, Melanie Schernthaner, Margaretha Rudas, Panagiotis Kapetas, Maria Bernathova, Julia Furtner, Katja Pinker, Thomas H Helbich, Pascal A T Baltzer
OBJECTIVES: To assess whether using the Tree flowchart obviates unnecessary magnetic resonance imaging (MRI)-guided biopsies in breast lesions only visible on MRI. METHODS: This retrospective IRB-approved study evaluated consecutive suspicious (BI-RADS 4) breast lesions only visible on MRI that were referred to our institution for MRI-guided biopsy. All lesions were evaluated according to the Tree flowchart for breast MRI by experienced readers. The Tree flowchart is a decision rule that assigns levels of suspicion to specific combinations of diagnostic criteria...
March 8, 2017: European Radiology
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