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Breast cancer, MRI

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https://www.readbyqxmd.com/read/29168005/a-survey-by-the-european-society-of-breast-imaging-on-the-utilisation-of-breast-mri-in-clinical-practice
#1
Paola Clauser, Ritse Mann, Alexandra Athanasiou, Helmut Prosch, Katja Pinker, Matthias Dietzel, Thomas H Helbich, Michael Fuchsjäger, Julia Camps-Herrero, Francesco Sardanelli, Gabor Forrai, Pascal A T Baltzer
OBJECTIVES: While magnetic resonance imaging (MRI) is considered a helpful diagnostic tool in breast imaging, discussions are ongoing about appropriate protocols and indications. The European Society of Breast Imaging (EUSOBI) launched a survey to evaluate the utilisation of breast MRI in clinical practice. METHODS: An online survey reviewed by the EUSOBI board and committees was distributed amongst members. The questions encompassed: training and experience; annual breast MRI and MRI-guided-intervention workload; examination protocols; indications; reporting habits and preferences...
November 22, 2017: European Radiology
https://www.readbyqxmd.com/read/29159779/simultaneous-whole-body-and-breast-18f-fdg-pet-mri-examinations-in-patients-with-breast-cancer-a-comparison-of-apparent-diffusion-coefficients-and-maximum-standardized-uptake-values
#2
Michiro Sasaki, Mitsuhiro Tozaki, Kazunori Kubota, Wakana Murakami, Daisuke Yotsumoto, Yasuaki Sagara, Yasuyo Ohi, Shunichi Oosako, Yoshiaki Sagara
PURPOSE: To compare standardized uptake value (SUV) and apparent diffusion coefficient (ADC) values acquired using a PET/MRI scanner in breast cancer patients. MATERIALS AND METHODS: Whole-body PET/MRI and breast PET/MRI were performed in 108 consecutive patients. Ninety-four patients who had a total of 100 breast cancers were analyzed. SUVmax and ADCmean acquired using breast PET/MRI were compared with pathologic prognostic factors. RESULTS: All the lesions were visually detectable using PET and diffusion-weighted imaging (DWI) on breast PET/MRI; however, lesions were visually undetectable on whole-body DWI in 13 patients (13%) or on whole-body PET in 7 patients (7%)...
November 20, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29156805/circulating-tumor-dna-shows-variable-clonal-response-of-breast-cancer-during-neoadjuvant-chemotherapy
#3
Ji-Yeon Kim, Donghyun Park, Dae-Soon Son, Seok Jin Nam, Seok Won Kim, Hae Hyun Jung, Yeon Jeong Kim, Gahee Park, Woong-Yang Park, Jeong Eon Lee, Yeon Hee Park
Circulating tumor DNA (ctDNA) correlates with tumor burden and provides early detection of treatment response and tumor genetic alterations in breast cancer (BC). In this study, we aimed to identify genetic alterations during the process of tumor clonal evolution and examine if ctDNA level well indicated clinical response to neoadjuvant chemotherapy (NAC) and BC recurrence. We performed targeted ultra-deep sequencing of plasma DNAs, matched germline DNAs and tumor DNAs from locally advanced BC patients. Serial plasma DNAs were collected at diagnosis, after the 1(st) cycle of NAC and after curative surgery...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155879/subtypes-of-breast-cancer-show-different-spatial-distributions-of-brain-metastases
#4
Sunghyon Kyeong, Yoon Jin Cha, Sung Gwe Ahn, Sang Hyun Suh, Eun Ju Son, Sung Jun Ahn
The aim of our study was to test the hypothesis that the spatial distribution of breast cancer brain metastases (BM) differ according to their biological subtypes. MR images of 100 patients with BM from primary breast cancer were retrospectively reviewed. Patients were divided according to the biological subtype of the primary tumor, (triple-negative: 24, HER2 positive: 48, luminal: 28). All images marked with BMs were standardized to the human brain MRI atlas provided by the Montreal Neurological Institute 152 database...
2017: PloS One
https://www.readbyqxmd.com/read/29153365/comparison-of-screening-cedm-and-mri-for-women-at-increased-risk-for-breast-cancer-a-pilot-study
#5
Maxine S Jochelson, Katja Pinker, D David Dershaw, Mary Hughes, Girard F Gibbons, Kareem Rahbar, Mark E Robson, Debra A Mangino, Debra Goldman, Chaya S Moskowitz, Elizabeth A Morris, Janice S Sung
OBJECTIVES: Contrast enhanced digital mammography (CEDM) is a new breast imaging technology increasingly used in the diagnostic setting but its utility in the pure screening setting has not been reported. The goal of this pilot study is to prospectively compare screening CEDM to breast MRI in women with an increased risk for breast cancer. METHODS: In this IRB-approved HIPAA-compliant study, 318 women at increased breast cancer risk were consented (December 2012-May 2015) to undergo CEDM in addition to their scheduled MRI...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29152563/integrated-radiomic-framework-for-breast-cancer-and-tumor-biology-using-advanced-machine-learning-and-multiparametric-mri
#6
Vishwa S Parekh, Michael A Jacobs
Radiomics deals with the high throughput extraction of quantitative textural information from radiological images that not visually perceivable by radiologists. However, the biological correlation between radiomic features and different tissues of interest has not been established. To that end, we present the radiomic feature mapping framework to generate radiomic MRI texture image representations called the radiomic feature maps (RFM) and correlate the RFMs with quantitative texture values, breast tissue biology using quantitative MRI and classify benign from malignant tumors...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29142626/resection-and-observation-for-brain-metastasis-without-prompt-postoperative-radiation-therapy
#7
Tae-Wook Song, In-Young Kim, Shin Jung, Tae-Young Jung, Kyung-Sub Moon, Woo-Youl Jang
Objective: Total resection without consecutive postoperative whole brain radiation therapy is indicated for patients with a single or two sites of brain metastasis, with close follow-up by serial magnetic resonance imaging (MRI). In this study, we explored the effectiveness, usefulness, and safety of this follow-up regimen. Methods: From January 2006 to December 2015, a total of 109 patients (76 males, 33 females) underwent tumor resection as the first treatment for brain metastases (97 patients with single metastases, 12 with two metastases)...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29140576/comparison-between-qualitative-and-quantitative-assessment-of-background-parenchymal-enhancement-on-breast-mri
#8
Akshat C Pujara, Artem Mikheev, Henry Rusinek, Yiming Gao, Chloe Chhor, Kristine Pysarenko, Harikrishna Rallapalli, Jerzy Walczyk, Melanie Moccaldi, James S Babb, Amy N Melsaether
BACKGROUND: Potential clinical implications of the level of background parenchymal enhancement (BPE) on breast MRI are increasing. Currently, BPE is typically evaluated subjectively. Tests of concordance between subjective BPE assessment and computer-assisted quantified BPE have not been reported. PURPOSE OR HYPOTHESIS: To compare subjective radiologist assessment of BPE with objective quantified parenchymal enhancement (QPE). STUDY TYPE: Cross-sectional observational study...
November 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29140420/growth-trajectories-breast-size-and-breast-tissue-composition-in-a-british-pre-birth-cohort-of-young-women
#9
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Martin O Leach, David J Hawkes, Isabel Dos-Santos-Silva
Mammographic % density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations between magnetic resonance imaging (MRI) breast-tissue composition at age 21 years and prospectively-collected measures of body size and composition from birth to early adulthood, and markers of puberty (all standardized), in a sample of 500 nulliparous women from a pre-birth cohort of children born in Avon, England, in 1991-1992 and followed up to 2011-2014...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29139055/downstream-breast-imaging-following-screening-mammography-in-medicare-patients-with-advanced-cancer-a-population-based-study
#10
Gelareh Sadigh, Richard Duszak, Kevin C Ward, Renjian Jiang, Jeffrey M Switchenko, Kimberly E Applegate, Ruth C Carlos
BACKGROUND: Screening tests are generally not recommended in patients with advanced cancer and limited life expectancy. Nonetheless, screening mammography still occurs and may lead to follow-up testing. OBJECTIVE: We assessed the frequency of downstream breast imaging following screening mammography in patients with advanced colorectal or lung cancer. DESIGN: Population-based study. PARTICIPANTS: The study included continuously enrolled female fee-for-service Medicare beneficiaries ≥65 years of age with advanced colorectal (stage IV) or lung (stage IIIB-IV) cancer reported to a Surveillance, Epidemiology, and End Results (SEER) registry between 2000 and 2011...
November 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29139006/correction-to-usefulness-of-abbreviated-breast-mri-screening-for-women-with-a-history-of-breast-cancer-surgery
#11
Bo Hwa Choi, Nami Choi, Mi Young Kim, Jung-Hyun Yang, Young Bum Yoo, Hae Kyoung Jung
In the original publication of the article, the acknowledgment section was missed out inadvertently. The acknowledgement section is below.
November 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29137072/volume-based-metabolic-parameter-of-breast-cancer-on-preoperative-18f-fdg-pet-ct-could-predict-axillary-lymph-node-metastasis
#12
Young-Sil An, Doo Kyoung Kang, Yongsik Jung, Tae Hee Kim
The purpose of our study was to evaluate the association between metabolic parameters on FDG PET/CT and axillary lymph node metastasis (ALNM) in patients with invasive breast cancer.From January 2012 to December 2012, we analyzed 173 patients with invasive ductal carcinoma (IDC) who underwent both initial breast magnetic resonance imaging (MRI) and F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) examinations. All metabolic parameters were measured from the tumor volume segmented by a gradient-based method...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134565/prognostic-value-of-fdg-pet-and-dwi-in-breast-cancer
#13
Kazuhiro Kitajima, Yasuo Miyoshi, Toshiko Yamano, Soichi Odawara, Tomoko Higuchi, Koichiro Yamakado
OBJECTIVE: To investigate the prognostic value of preoperative FDG-PET/CT and diffusion weighted imaging (DWI) in patients with breast cancer. METHODS: A total of 73 patients with newly diagnosed invasive breast cancer who had undergone preoperative whole-body FDG-PET/CT and 3-Tesla breast MRI including DWI followed by surgery were identified. Effects of primary tumor PET parameters [maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] and DWI parameters [mean apparent diffusion coefficient (ADCmean) and minimum ADC (ADCmin)] including clinicopathologic factors on disease-free survival (DFS) were retrospectively evaluated using the log-rank and Cox methods...
November 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29134357/apparent-diffusion-coefficient-of-vertebral-haemangiomas-allows-differentiation-from-malignant-focal-deposits-in-whole-body-diffusion-weighted-mri
#14
Jessica M Winfield, Gabriele Poillucci, Matthew D Blackledge, David J Collins, Vallari Shah, Nina Tunariu, Martin F Kaiser, Christina Messiou
OBJECTIVES: The aim of this study was to identify apparent diffusion coefficient (ADC) values for typical haemangiomas in the spine and to compare them with active malignant focal deposits. METHODS: This was a retrospective single-institution study. Whole-body magnetic resonance imaging (MRI) scans of 106 successive patients with active multiple myeloma, metastatic prostate or breast cancer were analysed. ADC values of typical vertebral haemangiomas and malignant focal deposits were recorded...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29134191/assessing-treatment-response-in-triple-negative-breast-cancer-from-quantitative-image-analysis-in-perfusion-magnetic-resonance-imaging
#15
Imon Banerjee, Sadhika Malladi, Daniela Lee, Adrien Depeursinge, Melinda Telli, Jafi Lipson, Daniel Golden, Daniel L Rubin
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is sensitive but not specific to determining treatment response in early stage triple-negative breast cancer (TNBC) patients. We propose an efficient computerized technique for assessing treatment response, specifically the residual tumor (RT) status and pathological complete response (pCR), in response to neoadjuvant chemotherapy. The proposed approach is based on Riesz wavelet analysis of pharmacokinetic maps derived from noninvasive DCE-MRI scans, obtained before and after treatment...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29127760/preoperative-breast-mri-examination-for-all-patients-with-histologically-proven-breast-cancer-a-concept-for-a-prospective-multicenter-trial
#16
Christina Kaiser, Christina Kehrer, Mignon-Denise Keyver-Paik, Thomas Hecking, Tiyasha Hosne Ayub, Claudia Leutner, Hans Schild, Walther Kuhn
Background A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies...
November 11, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29127715/relationship-between-preoperative-breast-mri-and-surgical-treatment-of-non-metastatic-breast-cancer
#17
Tracy Onega, Julie E Weiss, Martha E Goodrich, Weiwei Zhu, Wendy B DeMartini, Karla Kerlikowske, Elissa Ozanne, Anna N A Tosteson, Louise M Henderson, Diana S M Buist, Karen J Wernli, Sally D Herschorn, Elise Hotaling, Cristina O'Donoghue, Rebecca Hubbard
BACKGROUND AND OBJECTIVES: More extensive surgical treatments for early stage breast cancer are increasing. The patterns of preoperative MRI overall and by stage for this trend has not been well established. METHODS: Using Breast Cancer Surveillance Consortium registry data from 2010 through 2014, we identified women with an incident non-metastatic breast cancer and determined use of preoperative MRI and initial surgical treatment (mastectomy, with or without contralateral prophylactic mastectomy (CPM), reconstruction, and breast conserving surgery ± radiation)...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29127249/-18-f-fdg-pet-ct-for-monitoring-response-to-therapy-of-choroidal-metastasis
#18
Naghmehossadat Eshghi, John Christoforidis, Phillip Kuo
A 38-year-old woman with metastatic breast carcinoma reported seeing "halos and flashes" in her left eye. Funduscopic exam revealed an elevated mass in the choroid of the left globe consistent with metastasis. Subsequent (18)F-FDG PET/CT revealed focal uptake in the nasal aspect of the left choroid of the eye corresponding to the mass seen on the funduscopic exam. Through correlation with the PET/CT, the lesion was retrospectively identified on the MRI. (18)F-FDG PET/CT post-radiotherapy showed complete response and thus supports that this imaging modality can be used for diagnosis and monitoring response...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29125427/the-surgical-treatment-of-metastatic-spine-tumors-within-the-intramedullary-compartment
#19
Ben A Strickland, Ian E McCutcheon, Indro Chakrabarti, Laurence D Rhines, Jeffrey S Weinberg
OBJECTIVE Metastasis to the spinal cord is rare, and optimal management of this disease is unclear. The authors investigated this issue by analyzing the results of surgical treatment of spinal intramedullary metastasis (IM) at a major cancer center. METHODS The authors retrospectively reviewed the medical records of 13 patients who underwent surgery for IM. Patients had renal cell carcinoma (n = 4), breast carcinoma (n = 3), melanoma (n = 2), non-small cell lung cancer (n = 1), sarcoma (n = 1), adenoid cystic carcinoma (n = 1), and cervical cancer (n = 1)...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29122667/is-breast-mri-a-helpful-additional-diagnostic-test-in-suspicious-mammographic-microcalcifications
#20
Pascal A T Baltzer, Barbara Bennani-Baiti, Alexander Stöttinger, Alexander Bumberger, Panagiotis Kapetas, Paola Clauser
PURPOSE: Microcalcifications are a common finding in mammography and usually require invasive procedures to diagnose or exclude malignancy. As many microcalcifications are due to benign lesions, we wanted to assess whether breast MRI as an additional diagnostic tool may be used to distinguish benign from malignant in this setting. MATERIALS AND METHODS: Eligible for this retrospective, IRB-approved observational study were 858 consecutive patients (mean age 54±11years) undergoing stereotactically-guided biopsies of suspicious mammographic microcalcifications during three year at our institution...
November 6, 2017: Magnetic Resonance Imaging
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