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Breast cancer, MRI

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https://www.readbyqxmd.com/read/28445295/metastatic-breast-cancer-to-the-rectum-a-case-report-with-emphasis-on-mri-features
#1
Li Ching Lau, Bernard Wee, Shi Wang, Yee Liang Thian
RATIONALE: Less than 1% of breast carcinomas metastasize to the gastrointestinal tract. The diagnosis is frequently not recognized especially when the history of breast carcinoma is remote. PATIENT CONCERNS: A 61-year-old female with a remote history of breast carcinoma presented with a 3-month history of change in bowel habits. Colonoscopy showed a circumferential rectal mass with initial impression of primary rectal cancer. MRI of the rectum showed findings that are atypical for primary rectal cancer...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28437222/laparoscopic-anatomical-segment-2-segmentectomy-by-the-glissonian-approach
#2
Kit-Man Ho, Ho-Seong Han, Yoo-Seok Yoon, Jai Young Cho, Young Rok Choi, Jae Seong Jang, Seong Uk Kwon, Sungho Kim, Jang Kyu Choi
BACKGROUND: When hepatocellular carcinoma (HCC) was located in segment 2 (S2), segment-oriented hepatectomy was more beneficial than left lateral sectionectomy as this type of anatomical resection preserved the volume of the nontumor-bearing segment. Herein, we presented 2 cases (1 with video) of laparoscopic anatomical S2 segmentectomy by the Glissonian approach. METHODS: The first patient was a 69-year-old woman, who had an incidentally detected liver nodule on abdominal ultrasound for systemic surveillance for her breast cancer...
October 19, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28435432/foundation-and-methodologies-in-computer-aided-diagnosis-systems-for-breast-cancer-detection
#3
REVIEW
Afsaneh Jalalian, Syamsiah Mashohor, Rozi Mahmud, Babak Karasfi, M Iqbal B Saripan, Abdul Rahman B Ramli
Breast cancer is the most prevalent cancer that affects women all over the world. Early detection and treatment of breast cancer could decline the mortality rate. Some issues such as technical reasons, which related to imaging quality and human error, increase misdiagnosis of breast cancer by radiologists. Computer-aided detection systems (CADs) are developed to overcome these restrictions and have been studied in many imaging modalities for breast cancer detection in recent years. The CAD systems improve radiologists' performance in finding and discriminating between the normal and abnormal tissues...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28433532/exci-cest-exploiting-pharmaceutical-excipients-as-mri-cest-contrast-agents-for-tumor-imaging
#4
Dario Livio Longo, Fatima Zzahra Moustaghfir, Alexandre Zerbo, Lorena Consolino, Annasofia Anemone, Martina Bracesco, Silvio Aime
Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Here we investigated the MRI-CEST properties of several excipients (ascorbic acid, sucrose, N-acetyl-d-glucosamine, meglumine and 2-pyrrolidone) and tested them as tumor-detecting agents in two different murine tumor models (breast and melanoma cancers)...
April 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28432515/mri-predicts-pathologic-complete-response-in-her2-positive-breast-cancer-after-neoadjuvant-chemotherapy
#5
Mette S van Ramshorst, Claudette E Loo, Emilie J Groen, Gonneke H Winter-Warnars, Jelle Wesseling, Frederieke van Duijnhoven, Marie-Jeanne T Vrancken Peeters, Gabe S Sonke
BACKGROUND: Neoadjuvant treatment of HER2-positive breast cancer frequently leads to a pathologic complete response (pCR), which is associated with favourable long-term outcome. Treatment regimens typically consist of 6-9 cycles of trastuzumab-based chemotherapy, although many patients achieve early radiologic complete response (rCR). If rCR accurately predicts pCR, the number of chemotherapy cycles can possibly be reduced. METHODS: We performed a diagnostic accuracy study to determine the association between rCR and pCR in patients with stage II-III HER2-positive breast cancer treated with neoadjuvant trastuzumab-based chemotherapy at the Netherlands Cancer Institute...
April 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28428649/role-of-magnetic-resonance-imaging-in-the-planning-of-breast-cancer-treatment-strategies-comparison-with-conventional-imaging-techniques
#6
Luciana Karla Lira França, Almir Galvão Vieira Bitencourt, Hugo Lamartine Souza Paiva, Caroline Baptista Silva, Nara Pacheco Pereira, Jociana Paludo, Luciana Graziano, Camila Souza Guatelli, Juliana Alves de Souza, Elvira Ferreira Marques
OBJECTIVE: To assess the role of magnetic resonance imaging (MRI) in the planning of breast cancer treatment strategies. MATERIALS AND METHODS: The study included 160 women diagnosed with breast cancer, who underwent breast MRI for preoperative staging. Using Pearson's correlation coefficient (r), we compared the size of the primary tumor, as determined by MRI, by conventional imaging (mammography and ultrasound), and in the pathological examination (gold standard)...
March 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28427271/the-value-of-pre-and-post-neoadjuvant-chemotherapy-f-18-fdg-pet-ct-scans-in-breast-cancer-comparison-with-mri
#7
Eun Kyoung Choi, Ie Ryung Yoo, Sung Hun Kim, Sonya Youngju Park, Joo Hyun O, Bong Joo Kang
Background Accurate assessment of neoadjuvant chemotherapy (NAC) response with positron emission tomography/computed tomography (PET/CT) or magnetic resonance imaging (MRI) may provide appropriate operation guidelines for individual breast cancer patients. Purpose To compare the values of PET/CT and MRI for response evaluation following NAC in breast cancer patients. Material and Methods Thirty-three consecutive patients who underwent NAC were included. PET/CT and MRI were performed before and one to four weeks after NAC...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28411677/breast-density-legislation-and-clinical-evidence
#8
REVIEW
Regina J Hooley
Breast density inform legislation is widely accepted in the United States and has fueled research regarding the clinical significance of dense breast tissue present on mammography and the value of supplemental screening. This article reviews the origins and current status of breast density inform laws and strategies for optimal breast density determination. Clinical evidence that dense breast tissue is associated with increased breast cancer risk is presented, together with a review of relative risk compared with other risk factors...
May 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28409837/clinical-accuracy-of-preoperative-breast-mri-for-breast-cancer
#9
Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G Spear, Jacob Ecanow, Chi-Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J Winchester, Catherine E Pesce, Sarah Rabbitt, Katharine Yao
BACKGROUND: It is unclear if breast magnetic resonance imaging (MRI) is more accurate than mammography (MGM) and ultrasound (U/S) in aggregate for patients with invasive cancer. METHODS: We compared concordance of combined tumor size and tumor foci between MRI and MGM and U/S combined to pathological tumor size and foci as the gold standard from 2009 to 2015. Tumor size was nonconcordant if it differed from the pathologic size by ≥33% and tumor foci was nonconcordant if >1 foci were seen...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28403971/-performances-of-breast-magnetic-resonance-imaging-in-the-context-of-neoadjuvant-chemotherapy-for-breast-cancer-to-predict-pathological-complete-response
#10
C Brisson, C Diguisto, A Vildé, G Body, F Arbion, J Leveque, L Ouldamer
PURPOSE: The objective of this work was to estimate the reliability of MRI after neoadjuvant chemotherapy (NAC) for breast cancer to detect a residual tumour by comparing the tumoral size measured by MRI with the histological size. We also estimated the concordance of diagnosis of complete pathological response between histological examination and MRI. MATERIALS AND METHODS: We included all the patients who received a neoadjuvant chemotherapy for breast cancer in the university hospital of Tours from January, 2008 to December 31st, 2012 and in the comprehensive cancer centre of Rennes from January, 2008 till May 31st 201...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28397346/magnetic-resonance-imaging-patterns-of-tumor-regression-in-breast-cancer-patients-after-neo-adjuvant-chemotherapy-and-an-analysis-of-the-influencing-factors
#11
ManMan Li, Bin Xu, Yingbo Shao, Hui Liu, BingJie Du, JunHui Yuan
The objective of this study was to analyze the patterns of breast tumor shrinkage in patients after neo-adjuvant chemotherapy (NAC) based on magnetic resonance imaging (MRI), and to evaluate the influential factors. Preoperative breast dynamic contrast-enhanced MRI was performed on 88 patients before NAC, every 2 weeks during their chemotherapy treatment, and the week before their surgery. The MRI enhancement pattern of the primary tumors was classified into one of four categories based on BI-RADS-MRI: type I (postcontrast mass image), II (multiple small masses image), III (postcontrast mass image with peripheral non-mass enhancement image), and IV (nonmass enhancement image)...
April 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28397344/a-comparison-of-the-diagnostic-accuracy-of-magnetic-resonance-imaging-to-axillary-ultrasound-in-the-detection-of-axillary-nodal-metastases-in-newly-diagnosed-breast-cancer
#12
Matthew A Assing, Bhavika K Patel, Neel Karamsadkar, Jared Weinfurtner, Omar Usmani, John V Kiluk, Jennifer S Drukteinis
Patients with a diagnosis of invasive breast cancer are increasingly undergoing breast magnetic resonance imaging (MRI) for preoperative staging including evaluation of axillary lymph node metastases (ALNM). This retrospective study aims to evaluate the utility of adding axillary ultrasound (AUS) in the preoperative setting when an MRI is planned or has already been performed. This IRB approved, HIPAA compliant study reviewed a total of 271 patients with a new diagnosis of invasive breast cancer at a single institution, between June 1, 2010 and June 30, 2013...
April 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28390297/the-addition-of-whole-body-magnetic-resonance-imaging-to-body-computerised-tomography-alters-treatment-decisions-in-patients-with-metastatic-breast-cancer
#13
Michael Kosmin, Andreas Makris, Priya V Joshi, Mei-Lin Ah-See, David Woolf, Anwar R Padhani
AIM: Accurate evaluation of distribution of disease and response to systemic anti-cancer therapy (SACT) is important in the optimal management of metastatic breast cancer. Whole-body magnetic resonance imaging (WB-MRI) has increased accuracy over computerised tomography of the chest, abdomen and pelvis (CT-CAP) for detecting liver and bone disease, but its effect on patient management is largely unexplored. This study investigates the effects of using WB-MRI alongside CT-CAP on SACT decisions in standard clinical practice for patients with metastatic breast cancer...
April 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28383841/-atypical-presentation-of-a-breast-cancer-pituitary-metastasis
#14
J Langrand-Escure, A Vallard, J-Ph Suchaud, P Diao, N Magné
Pituitary metastasis occur in 1-5 % of patients with cancer. We report the discovery of a unique pituitary metastasis of breast cancer. A 67 years old woman was treated in 2003 for local adenocarcinoma. After bone metastatic relapse in 2008, the patient developed diplopia and diabetes insipidus. An MRI revealed a histologically proven metastatic pituitary nodule. Further explorations revealed failure of multiple endocrine axes. Pituitary metastases are relatively rare, but are probably under-diagnosed in the presence of advanced cancers with impaired general condition...
July 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28379128/-associated-factors-with-the-presence-of-secondary-neoplastic-cells-in-the-cerebrospinal-fluid-of-patients-with-suspected-carcinomatous-meningitis
#15
Fernando Warley, María Belén Binella, Diego Hernan Giunta, Cristina M Elizondo, Bruno Leonel Ferreyro, Lucia Caraballo
BACKGROUND: Improvement in oncologic therapy has increased survival in oncologic patients. There has been a concomitant increase in the incidence of secondary meningeal involvement. Early diagnosis is mandatory. OBJECTIVE: To identify factors associated with the presence of secondary neoplastic cells in cerebrospinal fluid of patients with suspected carcinomatous meningitis (CM) Methods: Cross-sectional study involving adult patients with solid cancer diagnosis and suspected CM between 2004 and 2014 at Hospital Italiano de Buenos Aires...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28377882/subtle-hippocampal-deformities-in-breast-cancer-survivors-with-reduced-episodic-memory-and-self-reported-cognitive-concerns
#16
Alexandra C Apple, Anthony J Ryals, Kathryn I Alpert, Lynne I Wagner, Pei-An Shih, Mehmet Dokucu, David Cella, Frank J Penedo, Joel L Voss, Lei Wang
Cancer survivors have lingering cognitive problems, however the anatomical basis for these problems has yet to be fully elucidated. Clinical studies as well as animal models of chemotherapy have pinpointed cell and volume loss to the hippocampus, however, few studies have performed shape analysis of the hippocampus on cancer survivors. This study used high-dimensional deformation mapping analysis to test whether localized hippocampal deformation differs in breast cancer survivors who received adjuvant chemotherapy coupled with hormone blockade therapy, and if deformation was related to subjective self-reported concerns and cognitive performance...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28376191/the-impact-of-social-contagion-on-physician-adoption-of-advanced-imaging-tests-in-breast-cancer
#17
Craig E Pollack, Pamela R Soulos, Jeph Herrin, Xiao Xu, Nicholas A Christakis, Howard P Forman, James B Yu, Brigid K Killelea, Shi-Yi Wang, Cary P Gross
Background: Magnetic resonance imaging (MRI) and positron emission tomography (PET) scans are widely used in breast cancer practice despite unproven benefits. We examined the extent to which social contagion is associated with adoption of these imaging modalities. Methods: We used Surveillance, Epidemiology, and End Results-Medicare to construct peer groups of physicians who shared patients during a baseline period when these imaging modalities were starting to disseminate into practice (2004-2006) and determined the potential impact of these peer groups during a follow-up period (2007-2009)...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28375584/fully-automated-segmentation-of-whole-breast-using-dynamic-programming-in-dynamic-contrast-enhanced-mr-images
#18
Luan Jiang, Xiaoxin Hu, Qin Xiao, Yajia Gu, Qiang Li
PURPOSE: Amount of fibroglandular tissue (FGT) and level of background parenchymal enhancement (BPE) in breast dynamic contrast enhanced magnetic resonance images (DCE-MRI) are suggested as strong indices for assessing breast cancer risk. Whole breast segmentation is the first important task for quantitative analysis of FGT and BPE in three-dimensional (3-D) DCE-MRI. The purpose of this study is to develop and evaluate a fully automated technique for accurate segmentation of the whole breast in 3-D fat-suppressed DCE-MRI...
April 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28374581/-one-for-all-type-biodegradable-prussian-blue-manganese-dioxide-hybrid-nanocrystal-for-trimodal-imaging-guided-photothermal-therapy-and-oxygen-regulation-of-breast-cancer
#19
Jinrong Peng, Mingling Dong, Bei Ran, Wenting Li, Ying Hao, Qian Yang, Liwei Tan, Kun Shi, Zhiyong Qian
Multimodal imaging-guided diagnosis and therapy has been highlighted in the area of theranostic nanomaterials. To provide more suitable theranostic candidates, Prussian blue (PB)/manganese dioxide (MnO2) hybrid nanoparticles (PBMn) smaller than 50 nm are prepared by a one-pot method. MnO2, which is reduced from KMnO4, not only controls the particle size, the optical properties, and the transverse relaxation rate (r2) of PB but also enhances the catalysis efficacy of PB to H2O2 for oxygen generation. PBMn can serve as a photoacoustic imaging (PAI) and longitudinal relaxation (T1) mode magnetic resonance imaging contrast agent (14 times and 1...
April 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28374502/the-role-of-digital-breast-tomosynthesis-in-the-breast-assessment-clinic-a-review
#20
REVIEW
Suneeta Mall, Sarah Lewis, Patrick Brennan, Jennie Noakes, Claudia Mello-Thoms
Mammography has long been considered as the primary technique in breast cancer detection and assessment. Despite low specificity, mammography has been preferred over other contemporary techniques such as magnetic resonance imaging (MRI), computed tomography (CT) and ultrasonography (US) due to superior sensitivity and significant health economic benefits. The development of a new technique, a limited angle cone beam pseudo-three-dimensional tomosynthesis, digital breast tomosynthesis (DBT), has gained momentum...
April 4, 2017: Journal of Medical Radiation Sciences
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