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Breast cancer, MRI

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https://www.readbyqxmd.com/read/29770848/imaging-biomarkers-from-multiparametric-magnetic-resonance-imaging-are-associated-with-survival-outcomes-in-patients-with-brain-metastases-from-breast-cancer
#1
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29770285/large-non-enhancing-breast-cancer-on-breast-magnetic-resonance-imaging-a-case-report
#2
Johannes Peters, Wei Che Tsai, Gudrun Peters
A 55-year-old female presented with vague symptoms in the lateral left breast. Digital breast tomosynthesis and breast ultrasound showed no focal lesion, and magnetic resonance imaging (MRI) was subsequently performed. No suspicious enhancement was seen on MRI; in particular, no suspicious lesion was seen in the area of clinical concern. In view of persisting focal mastalgia and vague parenchymal changes in the symptomatic area on repeat targeted ultrasound, a core biopsy was performed. Final pathology after left mastectomy with axillary clearance showed a 42 mm grade 2 invasive ductal carcinoma...
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29768474/sonographic-visualization-of-nipple-blood-flow-can-help-differentiate-paget-disease-from-benign-eczematous-nipple-lesions
#3
Hideaki Ogata, Yukio Mitsuzuka, Naoko Honma, Miho Yoshida, Makoto Sumazaki, Fumi Saito, Masahiro Kobayashi, Kazutoshi Shibuya, Tetsuo Mikami, Hironori Kaneko
PURPOSE: Paget disease of the breast is a rare cancer that originates from the nipple-areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease. METHODS: In this retrospective study, 12 patients with pathologically proven unilateral nipple eczematous lesions (seven with Paget disease and five with simple dermatitis) were included...
2018: PloS One
https://www.readbyqxmd.com/read/29764199/change-in-microcalcifications-on-mammography-after-neoadjuvant-chemotherapy-in-breast-cancer-patients-correlation-with-tumor-response-grade-and-comparison-with-lesion-extent
#4
Hyunee Yim, Taeyang Ha, Doo Kyoung Kang, Seong Young Park, Yongsik Jung, Tae Hee Kim
Background After neoadjuvant chemotherapy (NAC), persistent microcalcifications are often observed in spite of a decrease in the primary tumor size. Purpose To analyze the changes in microcalcifications after NAC and to evaluate the accuracy of residual microcalcifications in predicting the extent of residual cancer. Material and Methods Eighty patients who received NAC and underwent both mammography and magnetic resonance imaging (MRI) before and after the completion of NAC were included. The location of microcalcifications was classified into two types: inside the mass and outside the mass...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29761357/classifying-brain-metastases-by-their-primary-site-of-origin-using-a-radiomics-approach-based-on-texture-analysis-a-feasibility-study
#5
Rafael Ortiz-Ramón, Andrés Larroza, Silvia Ruiz-España, Estanislao Arana, David Moratal
OBJECTIVE: To examine the capability of MRI texture analysis to differentiate the primary site of origin of brain metastases following a radiomics approach. METHODS: Sixty-seven untreated brain metastases (BM) were found in 3D T1-weighted MRI of 38 patients with cancer: 27 from lung cancer, 23 from melanoma and 17 from breast cancer. These lesions were segmented in 2D and 3D to compare the discriminative power of 2D and 3D texture features. The images were quantized using different number of gray-levels to test the influence of quantization...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29759590/reasons-for-non-participation-in-supplemental-population-based-mri-breast-screening-for-women-with-extremely-dense-breasts
#6
S V de Lange, M F Bakker, E M Monninkhof, P H M Peeters, P K de Koekkoek-Doll, R M Mann, M J C M Rutten, R H C Bisschops, J Veltman, K M Duvivier, M B I Lobbes, H J de Koning, N Karssemeijer, R M Pijnappel, W B Veldhuis, C H van Gils
AIM: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. MATERIALS AND METHODS: Between 2011 and 2015, 8,061 women (50-75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme...
May 11, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29758996/patterns-of-malignant-non-mass-enhancement-on-3-t-breast-mri-help-predict-invasiveness-using-the-bi-rads-lexicon-fifth-edition
#7
Seung Min Lee, Kyung Jin Nam, Ki Seok Choo, Jin You Kim, Dong Wook Jeong, Hyun Yul Kim, Jee Yeon Kim
Background Non-mass enhancements (NME) with invasive components account for 10-42% of total malignant NMEs. The factors associated with invasiveness on magnetic resonance imaging (MRI) could be useful for clinical assessment and treatment. Purpose To evaluate the clinical significances of the distributions and internal enhancement patterns (IEP) of malignant NMEs on 3-T breast MRI. Material and Methods A total of 448 consecutive women with newly diagnosed breast cancer that had undergone preoperative MRI and surgery between February 2013 and March 2016 were identified...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29758503/mri-and-pet-ct-for-evaluation-of-the-pathological-response-to-neoadjuvant-chemotherapy-in-breast-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Huimin Li, Liang Yao, Penghui Jin, Lidong Hu, Xiaofei Li, Tiankang Guo, Kehu Yang
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. METHODS: Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT)...
May 11, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29754995/additive-benefit-of-radiomics-over-size-alone-in-the-distinction-between-benign-lesions-and-luminal-a-cancers-on-a-large-clinical-breast-mri-dataset
#9
Heather M Whitney, Nathan S Taylor, Karen Drukker, Alexandra V Edwards, John Papaioannou, David Schacht, Maryellen L Giger
RATIONALE AND OBJECTIVES: The objective of this study was to demonstrate improvement in distinguishing between benign lesions and luminal A breast cancers in a large clinical breast magnetic resonance imaging database by using quantitative radiomics over maximum linear size alone. MATERIALS AND METHODS: In this retrospective study, 212 benign lesions and 296 luminal A breast cancers were automatically segmented from dynamic contrast-enhanced breast magnetic resonance images...
May 10, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29752327/adherence-to-guidelines-for-breast-surveillance-in-breast-cancer-survivors
#10
Kathryn J Ruddy, Lindsey Sangaralingham, Rachel A Freedman, Sarah Mougalian, Heather Neuman, Caprice Greenberg, Ahmedin Jemal, Narjust Duma, Tufia C Haddad, Valerie Lemaine, Karthik Ghosh, Tina J Hieken, Katie Hunt, Celine Vachon, Cary Gross, Nilay D Shah
Background: Guidelines recommend annual mammography after curative-intent treatment for breast cancer. The goal of this study was to assess contemporary patterns of breast imaging after breast cancer treatment. Methods: Administrative claims data were used to identify privately insured and Medicare Advantage beneficiaries with nonmetastatic breast cancer who had residual breast tissue (not bilateral mastectomy) after breast surgery between January 2005 and May 2015. We calculated the proportion of patients who had a mammogram, MRI, both, or neither during each of 5 subsequent 13-month periods...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29742918/can-unenhanced-mri-of-the-breast-replace-contrast-enhanced-mri-in-assessing-response-to-neoadjuvant-chemotherapy
#11
Beatrice Cavallo Marincola, Marianna Telesca, Fulvio Zaccagna, Frank Riemer, Michele Anzidei, Carlo Catalano, Federica Pediconi
Background The goals of neoadjuvant chemotherapy (NAC) are to reduce tumor volume and to offer a prognostic indicator in assessing treatment response. Contrast-enhanced magnetic resonance imaging (CE-MRI) is an established method for evaluating response to NAC in patients with breast cancer. Purpose To validate the role of unenhanced MRI (ue-MRI) compared to CE-MRI for assessing response to NAC in women with breast cancer. Material and Methods Seventy-one patients with ongoing NAC for breast cancer underwent MRI before, during, and at the end of NAC...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29742727/preoperative-magnetic-resonance-imaging-characteristics-of-oval-circumscribed-fast-enhancing-lesions-in-patients-with-newly-diagnosed-breast-cancer
#12
Jong Yoon Lee, Mijung Jang, Sun Mi Kim, Bo La Yun, Ja Yoon Jang, Hye Shin Ahn
The aim of this study was to investigate the follow-up results and characteristics of oval circumscribed lesions with fast initial enhancement on preoperative magnetic resonance imaging (MRI) in patients with newly diagnosed breast cancer.Preoperative data from consecutive patients newly diagnosed with breast cancer between 2010 and 2013 were retrospectively reviewed. Only MRI reports containing, "oval shape, circumscribed margin, and fast initial enhancement," were extracted and analyzed. Follow-up results and clinical and pathological findings were evaluated...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29736850/contralateral-parenchymal-enhancement-on-dynamic-contrast-enhanced-mri-reproduces-as-a-biomarker-of-survival-in-er-positive-her2-negative-breast-cancer-patients
#13
Bas H M van der Velden, Elizabeth J Sutton, Luca A Carbonaro, Ruud M Pijnappel, Elizabeth A Morris, Kenneth G A Gilhuijs
OBJECTIVES: To assess whether contralateral parenchymal enhancement reproduces as an independent biomarker for patient survival in an independent patient cohort from a different cancer institution. METHODS: This is a HIPAA-compliant IRB approved retrospective study. Patients with ER-positive/HER2-negative operable invasive ductal carcinoma and preoperative dynamic contrast-enhanced MRI were consecutively included between 2005 and 2009. The parenchyma of the breast contralateral to known cancer was segmented automatically on MRI and contralateral parenchymal enhancement (CPE) was calculated...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29734483/role-of-dynamic-contrast-enhanced-mri-in-evaluating-the-association-between-contralateral-parenchymal-enhancement-and-survival-outcome-in-er-positive-her2-negative-node-negative-invasive-breast-cancer
#14
Gi Won Shin, Yang Zhang, Min Jung Kim, Min-Ying Su, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park
BACKGROUND: Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments. PURPOSE: To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer. STUDY TYPE: Retrospective. POPULATION: In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29734089/magnetic-luminescent-cerium-doped-gadolinium-aluminum-garnet-nanoparticles-for-simultaneous-imaging-and-photodynamic-therapy-of-cancer-cells
#15
Akhil Jain, Rina Koyani, Carlos Muñoz, Prakhar Sengar, Oscar E Contreras, Patricia Juárez, Gustavo A Hirata
Nanoparticle (NP) and photosensitizer (PS) conjugates capable of X-ray photodynamic therapy (X-PDT) are a research focus due to their potential applications in cancer treatment. Combined with X-PDT, appropriate imaging properties of the nanocomposite will make it suitable for theranostics of deep lying tumors. In this work, we describe the development of magnetic-luminescent Gd2.98 Ce0.02 Al5 O12 nanoparticles (GAG) coated with mesoporous silica (mSiO2 ) and loaded with rose bengal (RB) to yield a nanocomposite GAG@mSiO2 @RB capable of X-PDT...
April 27, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29730399/multimodal-doxorubicin-loaded-magnetic-nanoparticles-for-vegf-targeted-theranostics-of-breast-cancer
#16
Alevtina S Semkina, Maxim A Abakumov, Alexander S Skorikov, Tatiana O Abakumova, Pavel A Melnikov, Nadejda F Grinenko, Sergey A Cherepanov, Daniil A Vishnevskiy, Victor A Naumenko, Klavdiya P Ionova, Alexander G Majouga, Vladimir P Chekhonin
In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%...
May 3, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29723846/diagnostic-value-of-nineteen-different-imaging-methods-for-patients-with-breast-cancer-a-network-meta-analysis
#17
Xiao-Hong Zhang, Can Xiao
BACKGROUND/AIMS: We performed a network meta-analysis (NMA) to investigate and compare the diagnostic value of 19 different imaging methods used for breast cancer (BC). METHODS: Cochrane Library, PubMed and EMBASE were searched to collect the relevant literature from the inception of the study until November 2016. A combination of direct and indirect comparisons was performed using an NMA to evaluate the combined odd ratios (OR) and draw the surface under the cumulative ranking curves (SUCRA) of the diagnostic value of different imaging methods for BC...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29721466/role-of-magnetic-resonance-imaging-in-breast-cancer-management
#18
Selvi Radhakrishna, S Agarwal, Purvish M Parikh, K Kaur, Shikha Panwar, Shelly Sharma, Ashish Dey, K K Saxena, Madhavi Chandra, Seema Sud
Magnetic resonance imaging (MRI) of the breast is primarily used as a supplemental tool to breast screening with mammography or ultrasound. A breast MRI is mainly used for women who have been diagnosed with breast cancer, to help measure the size of the cancer, look for other tumors in the breast, and to check for tumors in the opposite breast. For certain women at high risk for breast cancer, a screening MRI is recommended along with a yearly mammogram. MRI is known to give some false positive results which mean more test and/or biopsies for the patient...
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29720224/assessing-brain-volume-changes-in-older-women-with-breast-cancer-receiving-adjuvant-chemotherapy-a-brain-magnetic-resonance-imaging-pilot-study
#19
Bihong T Chen, Sean K Sethi, Taihao Jin, Sunita K Patel, Ningrong Ye, Can-Lan Sun, Russell C Rockne, E Mark Haacke, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, George Somlo, Daneng Li, Richard Yang, Heidi Tan, Vani Katheria, Rachel Morrison, Arti Hurria
BACKGROUND: Cognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy. Prior neuroimaging research has been performed mostly in younger patients with cancer. The purpose of this study was to evaluate longitudinal changes in brain volumes and cognition in older women with breast cancer receiving adjuvant chemotherapy. METHODS: Women aged ≥ 60 years with stage I-III breast cancer receiving adjuvant chemotherapy and age-matched and sex-matched healthy controls were enrolled...
May 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29717790/use-of-diffusion-kurtosis-imaging-and-quantitative-dynamic-contrast-enhanced-mri-for-the-differentiation-of-breast-tumors
#20
Ting Li, Tao Yu, Lyu Li, Lunbo Lu, Yaoyao Zhuo, Jingge Lian, Yun Xiong, Dexing Kong, Kangan Li
BACKGROUND: Breast MRI is a sensitive imaging technique to assess breast cancer but its effectiveness still remains to be improved. PURPOSE: To evaluate the diagnostic performance of diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), and quantitative dynamic contrast-enhanced (DCE)-MRI in differentiating malignant from benign breast lesions independently or jointly and to explore whether correlations exist among these parameters. STUDY TYPE: Retrospective...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
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