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Pancreatoduodenectomy

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https://www.readbyqxmd.com/read/29672406/number-of-examined-lymph-nodes-and-nodal-status-assessment-in-distal-pancreatectomy-for-body-tail-ductal-adenocarcinoma
#1
Giuseppe Malleo, Laura Maggino, Cristina R Ferrone, Giovanni Marchegiani, Mari Mino-Kenudson, Paola Capelli, Borislav Rusev, Keith D Lillemoe, Claudio Bassi, Carlos Fernàndez-Del Castillo, Roberto Salvia
OBJECTIVE: First, to assess the impact of the number of examined lymph nodes (ELNs) on staging and survival after distal pancreatectomy (DP) for pancreatic adenocarcinoma (PDAC). Second, to identify the minimum number of ELNs (MNELNs) ensuring an accurate detection of nodal involvement. Third, to reappraise the role of lymph node (LN) parameters, including N-status and lymph node ratio (LNR). BACKGROUND: In contrast with pancreatoduodenectomy, information on LN staging and the MNELN required in DP is lacking...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29664999/randomized-clinical-trial-of-the-effect-of-a-fibrin-sealant-patch-on-pancreatic-fistula-formation-after-pancreatoduodenectomy
#2
M Schindl, R Függer, P Götzinger, F Längle, M Zitt, S Stättner, P Kornprat, K Sahora, D Hlauschek, M Gnant
BACKGROUND: The potential for a fibrin sealant patch to reduce the risk of postoperative pancreatic fistula (POPF) remains uncertain. The aim of this study was to evaluate whether a fibrin sealant patch is able to reduce POPF in patients undergoing pancreatoduodenectomy with pancreatojejunostomy. METHODS: In this multicentre trial, patients undergoing pancreatoduodenectomy were randomized to receive either a fibrin patch (patch group) or no patch (control group), and stratified by gland texture, pancreatic duct size and neoadjuvant treatment...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29652079/meta-analysis-of-an-artery-first-approach-versus-standard-pancreatoduodenectomy-on-perioperative-outcomes-and-survival
#3
REVIEW
N Ironside, S G Barreto, B Loveday, S V Shrikhande, J A Windsor, S Pandanaboyana
BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate perioperative outcomes and survival in patients undergoing an artery-first approach to pancreatoduodenectomy in comparison with those having standard pancreatoduodenectomy. METHODS: A systematic search of PubMed, MEDLINE, Embase and the Cochrane Database of Systematic Reviews was performed in accordance with PRISMA guidelines. Comparative studies including patients who underwent artery-first pancreatoduodenectomy and standard pancreatoduodenectomy were analysed...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29650926/-a-resected-case-of-adenosquamous-carcinoma-of-pancreas-that-relapsed-in-remnant-pancreas
#4
Kotaro Miura, Akishige Kanazawa, Sadatoshi Shimizu, Akihiro Murata, Shintaro Kodai, Takafumi Nishii, Katsunobu Sakurai, Akiko Tachimori, Yutaka Tamamori, Naoshi Kubo, Toru Inoue, Yukio Nishiguchi
A 70's man underwent subtotal stomach preserving pancreatoduodenectomy(SSPPD)for pancreatic head cancer. The pathological diagnosis was adenosquamous carcinoma(ASC)of the pancreas. Two months after surgery, a recurrent tumor in the remnant pancreas was confirmed with a CT scan and suspected to be ASC by endoscopic ultrasound-guided fine needle aspiration(EUS-FNA). As the recurrent lesion was limited in the pancreas, total remnant pancreatectomy(TP)was performed 4 months after SSPPD. The final pathological diagnosis was ASC...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650915/-a-case-of-primary-duodenal-cancer-with-duodenocolic-fistula-treated-with-pancreatoduodenectomy-and-right-hemicolectomy
#5
Hideo Ota, Shigekazu Yokoyama, Eri Tanaka, Shigeto Nakai, Nobuo Takiguchi, Shoko Honda, Ryohei Yukimoto, Shinji Tokuyama, Akina Saito, Tomohira Takeoka, Hiroshi Matsuno, Ken Konishi, Kazuyuki Okada, Mutsumi Fukunaga, Kenji Kobayashi
A patient was 59-year-old female. She presented our hospital with weight loss, anorexia and lower abdominal bloating. Abdominal computed tomography(CT), gastrointestinal endoscopy, colonoscopy and duodenal fistulagram showed duodenal cancer or colon cancer with duodenocolic fistula and ovary metastasis. She underwent subtotal stomach preserving pancreatoduodenectomy and right hemicolectomy. In these pathological findings, tumor was diagnosed as a duodenal cancer with duodenocolic fistula. She was surviving 12 months after the last surgery...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650912/-two-cases-of-neuroendocrine-carcinoma-of-the-non-ampullary-duodenum
#6
Miho Watanabe, Shigeru Fujisaki, Motoi Takashina, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
Here we report 2 cases of neuroendocrine carcinoma(NEC)of the non-ampullary duodenum which is extremely rare neoplasm. Case 1: A 76-year-old man had a type 2 duodenal carcinoma with a 3 cm-sized lymph node metastasis. Duodenal resection with subpyloric lymph nodes dissection and Roux-en-Y reconstruction were performed. The histopathological diagnosis was NEC of the duodenal bulb after surgery(pT3pN1M0, stage III A, UICC 7th edition). The patient died of chronic heart failure 10 years and 3 months after the surgery...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650056/pancreatoduodenectomy-with-or-without-prophylactic-falciform-ligament-wrap-around-the-gastroduodenal-artery-stump-for-prevention-of-pancreatectomy-hemorrhage
#7
Benjamin Müssle, Leonie Zühlke, Ann Wierick, Dorothée Sturm, Xina Grählert, Marius Distler, Nuh N Rahbari, Jürgen Weitz, Thilo Welsch
BACKGROUND: The purpose of this study is to evaluate whether wrapping of the pedicled falciform ligamentum flap around the gastroduodenal artery (GDA) stump/hepatic artery can significantly decrease the incidence of erosion hemorrhage after pancreatoduodenectomy (PD). METHODS/DESIGN: This is a randomized controlled multicenter trial involving 400 patients undergoing PD. Patients will be randomized into two groups. The intervention group consists of 200 patients with a prophylactic wrapping of the GDA stump using the pedicled falciform ligament...
April 12, 2018: Trials
https://www.readbyqxmd.com/read/29642943/celiac-axis-stenosis-due-to-median-arcuate-ligament-compression-in-a-patient-who-underwent-pancreatoduodenectomy-intraoperative-assessment-of-hepatic-arterial-flow-using-doppler-ultrasonography-a-case-report
#8
Masateru Yamamoto, Toshiyuki Itamoto, Akihiko Oshita, Yasuhiro Matsugu
BACKGROUND: Celiac axis stenosis due to compression by the median arcuate ligament has been reported in patients undergoing pancreaticoduodenectomy; it leads to the development of major collateral pathways that feed the hepatic artery. Dividing these important collaterals during pancreaticoduodenectomy can cause ischemic complications which may lead to a high mortality rate. To prevent these complications, it is necessary to assess intrahepatic arterial flow. CASE PRESENTATION: A 71-year-old Japanese man with anorexia was referred to us for the treatment of alcoholic chronic pancreatitis...
April 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29616107/awareness-of-hepatic-arterial-variants-is-required-in-surgical-oncology-decision-making-strategy-case-report-and-review-of-literature
#9
Robert Sitarz, Monika Berbecka, Jerzy Mielko, Karol Rawicz-Pruszyński, Grzegorz Staśkiewicz, Ryszard Maciejewski, Wojciech Polkowski
Surgery for the treatment of pancreatic cancer remains the gold standard, however, the identification of the vascular supply of the pancreas and the nearby organs remains a crucial difficulties in a curative resection. During pancreatic head resection for carcinoma dissection of regional arterial vasculature is mandatory. Normal coeliac and hepatic arterial anatomy occurs in ~50-70% of patients and multiple variations have been described. Knowledge of multiple arterial anomalies is essential in hepato-pancreatico-billary surgery to avoid unnecessary complications...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29589102/dilemmas-for-the-pathologist-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens-an-overview-of-different-grossing-approaches-and-the-relevance-of-the-histopathological-characteristics-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens
#10
REVIEW
Eline Soer, Lodewijk Brosens, Marc van de Vijver, Frederike Dijk, Marie-Louise van Velthuysen, Arantza Farina-Sarasqueta, Hans Morreau, Johan Offerhaus, Lianne Koens, Joanne Verheij
A pancreatoduodenectomy specimen is complex, and there is much debate on how it is best approached by the pathologist. In this review, we provide an overview of topics relevant for current clinical practice in terms of gross dissection, and macro- and microscopic assessment of the pancreatoduodenectomy specimen with a suspicion of suspected pancreatic cancer. Tumor origin, tumor size, degree of differentiation, lymph node status, and resection margin status are universally accepted as prognostic for survival...
March 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29580215/nomograms-predict-long-term-survival-for-patients-with-periampullary-adenocarcinoma-after-pancreatoduodenectomy
#11
Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin, Shengping Li
BACKGROUND: The prognosis of patients with periampullary adenocarcinoma after pancreatoduodenectomy is diverse and not yet clearly illustrated. The aim of this study was to develop a nomogram to predict individual risk of overall survival (OS) and progression-free survival (PFS) in patients with periampullary adenocarcinoma after pancreatoduodenectomy. METHODS: A total of 205 patients with periampullary adenocarcinoma after pancreatoduodenectomy were retrospectively included...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29574096/measurement-of-indicator-genes-using-global-complementary-dna-cdna-amplification-by-polyadenylic-acid-reverse-transcriptase-polymerase-chain-reaction-poly-a-rt-pcr-a-feasibility-study-using-paired-samples-from-tissue-and-ductal-juice-in-patients-undergoing
#12
Sudip Sanyal, Ajith K Siriwardena, Richard Byers
OBJECTIVES: The aim of this study is to compare gene expression profiles in RNA isolated from pancreatic ductal juice with the RNA expression profiles of the same genes from matched intra-operative tissue samples from pancreatic tumours. METHODS: Intra-operative sampling of pancreatic juice and collection of matched tissue samples was undertaken in patients undergoing pancreatoduodenectomy for clinically suspected pancreatic cancer and a precursor lesion, main-duct intraductal papillary mucinous neoplasm...
March 20, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29572825/new-onset-non-alcoholic-fatty-liver-disease-after-resection-of-pancreatic-neuroendocrine-tumors
#13
Tara Michella Mackay, Cansu Güney Genç, Robert Bart Takkenberg, Marc Gerard Besselink, Inne Somers, Elisabeth Jacqueline Maria Nieveen van Dijkum
BACKGROUND AND OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatis (NASH) may occur after pancreatic resection due to exocrine pancreatic insufficiency (EPI). Patients with long-term survival, such as after pancreatic neuroendocrine tumor (pNET) resection, are at risk of NAFLD/NASH. We aimed to determine the incidence and risk factors for new onset NAFLD/NASH and EPI after pNET resection. METHODS: Retrospective monocenter cohort study...
March 24, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29571615/variation-in-hospital-mortality-after-pancreatoduodenectomy-is-related-to-failure-to-rescue-rather-than-major-complications-a-nationwide-audit
#14
Lennart B van Rijssen, Maurice J Zwart, Susan van Dieren, Thijs de Rooij, Bert A Bonsing, Koop Bosscha, Ronald M van Dam, Casper H van Eijck, Michael F Gerhards, Josephus J Gerritsen, Erwin van der Harst, Ignace H de Hingh, Koert P de Jong, Geert Kazemier, Joost Klaase, Berendina M van der Kolk, Cornelis J van Laarhoven, Misha D Luyer, Isaac Q Molenaar, Gijs A Patijn, Coen G Rupert, Joris J Scheepers, George P van der Schelling, Alexander L Vahrmeijer, Olivier R C Busch, Hjalmar C van Santvoort, Bas Groot Koerkamp, Marc G Besselink
BACKGROUND: In the mandatory nationwide Dutch Pancreatic Cancer Audit, rates of major complications and Failure to Rescue (FTR) after pancreatoduodenectomy between low- and high-mortality hospitals are compared, and independent predictors for FTR investigated. METHODS: Patients undergoing pancreatoduodenectomy in 2014 and 2015 in The Netherlands were included. Hospitals were divided into quartiles based on mortality rates. The rate of major complications (Clavien-Dindo ≥3) and death after a major complication (FTR) were compared between these quartiles...
March 20, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29559056/evaluation-of-drain-amylase-level-after-pancreaticoduodenectomy-with-special-reference-to-delayed-pancreatic-fistula
#15
Takashi Maeda, Hiroto Kayashima, Daisuke Imai, Kazuki Takeishi, Noboru Harada, Eiji Tsujita, Shinichi Tsutsui, Hiroyuki Matsuda
Postoperative pancreatic fistula (PF) is a relatively frequent and occasionally fatal complication of pancreatoduodenectomy (PD). Several risk factors for PF have been reported, including high drain amylase level (D-AMY). Among the 140 consecutive patients who underwent PD, we analyzed 110 cases with D-AMY measurements over time after PD. According to the D-AMY change, we divided patients into five patterns and defined delayed PF cases. We analyzed clinical characteristics, including serum amylase and D-AMY, and examined the correlation between the period of drain insertion and PF grade...
March 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29548873/is-percutaneous-transhepatic-biliary-drainage-better-than-endoscopic-drainage-in-the-management-of-jaundiced-patients-awaiting-pancreaticoduodenectomy-a-systematic-review-and-meta-analysis
#16
Dimitri Dorcaratto, Niamh M Hogan, Elena Muñoz, Marina Garcés, Paolo Limongelli, Luis Sabater, Joaquin Ortega
PURPOSE: To compare postoperative complications in patients who underwent pancreatoduodenectomy after either endoscopic or percutaneous biliary drain (BD). MATERIAL AND METHODS: Data from studies comparing the rate of postoperative complications in patients who underwent endoscopic BD or percutaneous BD before pancreatoduodenectomy were extracted independently by 2 investigators. The primary outcome compared in the meta-analysis was the risk of postoperative complications...
March 13, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29545971/modified-blumgart-anastomosis-without-pancreatic-duct-to-jejunum-mucosa-anastomosis-for-pancreatoduodenectomy-a-feasible-and-safe-novel-technique
#17
Xiaoqing Wang, Yang Bai, Mangmang Cui, Qingxiang Zhang, Wei Zhang, Feng Fang, Tianqiang Song
Objective: This study proposed a modified Blumgart anastomosis (m-BA) that uses a firm ligation of the main pancreatic duct with a supporting tube to replace the pancreatic duct-to-jejunum mucosa anastomosis, with the aim of simplifying the complicated steps of the conventional BA (c-BA). Thus, we observe if a difference in the risk of postoperative pancreatic fistula (POPF) exists between the two methods. Methods: The m-BA anastomosis method has been used since 2010...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29530827/contaminated-drainage-fluid-and-pancreatic-fistula-after-pancreatoduodenectomy-a-retrospective-study
#18
Kanefumi Yamashita, Daisuke Kato, Takamitsu Sasaki, Hironari Shiwaku, Fuminori Ishii, Shigetoshi Naito, Yuichi Yamashita, Suguru Hasegawa
BACKGROUND: Appropriate bacterial infection control in the perioperative period of a pancreaticoduodenectomy (PD) is important to prevent and manage serious complications including postoperative pancreatic fistula (POPF). In the present study, the clinical impact of bacterial contamination of intra-abdominal discharge on the rate of POPF after PD was analysed retrospectively. MATERIALS AND METHODS: The data for 82 consecutive patients who had undergone PD at our hospital between January 2009 and July 2014 were retrospectively analysed to review patient characteristics and perioperative and postoperative parameters...
March 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29526248/predictive-factors-of-endocrine-and-exocrine-insufficiency-after-resection-of-a-benign-tumour-of-the-pancreas
#19
Hélène Neophytou, Marc Wangermez, Elise Gand, Michel Carretier, Jérôme Danion, Jean-Pierre Richer
BACKGROUND: The aim of the present study is to evaluate the risk factors of endocrine and exocrine insufficiency occurring few years after pancreatic resections in a consecutive series of patients who underwent pancreatoduodenectomy (PD), left pancreatectomy (LP) or enucleation for benign neoplasms at a referral centre. METHODS: Pancreatic exocrine insufficiency (PEI) was defined by the onset of steatorrhea associated with weight loss, and endocrine insufficiency was determinate by fasting plasma glucose...
March 8, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29515347/a-bile-duct-stone-formation-around-a-fish-bone-as-a-nidus-after-pancreatoduodenectomy
#20
Tomoki Sakakida, Hideki Sato, Toshifumi Doi, Takumi Kawakami, Yoshikazu Nakatsugawa, Ken Nishimura, Shinya Yamada, Hideki Fujii, Naoya Tomatsuri, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida
We report a rare case of bile duct stone formation around an ingested fish bone as a nidus after pancreatoduodenectomy. A 78-year-old woman was admitted to our department for fever and epigastric pain. Abdominal computed tomography revealed an elongated bile duct stone containing a linearly shaped foreign body of bone density. Enteroscopic lithotomy was performed using single balloon enteroscopy to safely remove the stone and foreign body from the bile duct. The foreign body was determined to be a fish bone by pathological examination and component analysis...
January 2018: Case Reports in Gastroenterology
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