Matthew D Cheung, Rebecca Asiimwe, Elise N Erman, Christopher F Fucile, Shanrun Liu, Chiao-Wang Sun, Vidya Sagar Hanumanthu, Harish C Pal, Emma D Wright, Gelare Ghajar-Rahimi, Daniel Epstein, Babak J Orandi, Vineeta Kumar, Douglas J Anderson, Morgan E Greene, Markayla Bell, Stefani Yates, Kyle H Moore, Jennifer LaFontaine, John T Killian, Gavin Baker, Jackson Perry, Zayd Khan, Rhiannon Reed, Shawn C Little, Alexander F Rosenberg, James F George, Jayme E Locke, Paige M Porrett
Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it is unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited pig kidney into a brain-dead human recipient on pharmacologic immunosuppression and study the human immune response to the xenograft using spatial transcriptomics and single-cell RNA sequencing. Human immune cells are uncommon in the porcine kidney cortex early after xenotransplantation and consist of primarily myeloid cells...
April 11, 2024: Nature Communications