Xiaolei Lin, Yi Lei, Miaozhen Pan, Changxi Hu, Bintao Xie, Wenjing Wu, Jianzhong Su, Yating Li, Yuhan Tan, Xiaohuan Wei, Zhengbo Xue, Ruiyan Xu, Mengqi Di, Hanyu Deng, Shengcong Liu, Xingxing Yang, Jia Qu, Wei Chen, Xiangtian Zhou, Fei Zhao
Myopia is characterized of maladaptive increases in scleral fibroblast-to-myofibroblast transdifferentiation (FMT). Scleral hypoxia is a significant factor contributing to myopia, but how hypoxia induces myopia is poorly understood. Here, we showed that myopia in mice and guinea pigs was associated with hypoxia-induced increases in key glycolytic enzymes expression and lactate levels in the sclera. Promotion of scleral glycolysis or lactate production induced FMT and myopia; conversely, suppression of glycolysis or lactate production eliminated or inhibited FMT and myopia...
January 9, 2024: Cell Metabolism