keyword
https://read.qxmd.com/read/36624107/gray-matter-volume-drives-the-brain-age-gap-in-schizophrenia-a-shap-study
#21
JOURNAL ARTICLE
Pedro L Ballester, Jee Su Suh, Natalie C W Ho, Liangbing Liang, Stefanie Hassel, Stephen C Strother, Stephen R Arnott, Luciano Minuzzi, Roberto B Sassi, Raymond W Lam, Roumen Milev, Daniel J Müller, Valerie H Taylor, Sidney H Kennedy, James P Reilly, Lena Palaniyappan, Katharine Dunlop, Benicio N Frey
Neuroimaging-based brain age is a biomarker that is generated by machine learning (ML) predictions. The brain age gap (BAG) is typically defined as the difference between the predicted brain age and chronological age. Studies have consistently reported a positive BAG in individuals with schizophrenia (SCZ). However, there is little understanding of which specific factors drive the ML-based brain age predictions, leading to limited biological interpretations of the BAG. We gathered data from three publicly available databases - COBRE, MCIC, and UCLA - and an additional dataset (TOPSY) of early-stage schizophrenia (82...
January 9, 2023: Schizophrenia (Heidelb)
https://read.qxmd.com/read/36610054/the-role-of-psychological-flexibility-in-the-relationships-between-burnout-job-satisfaction-and-mental-health-among-nurses-in-combatting-covid-19-a-two-region-survey
#22
JOURNAL ARTICLE
Yuen Yu Chong, Eveline Frey, Wai Tong Chien, Ho Yu Cheng, Andrew T Gloster
BACKGROUND: A growing body of evidence suggests that the COVID-19 pandemic is adversely impacting the mental health and well-being of frontline nurses worldwide. It is therefore important to understand how such impact can be mitigated, including by studying psychological capacities that could help the nurses regulate and minimize the impact. AIM: To examine the role of psychological flexibility in mitigating the adverse impacts of burnout and low job satisfaction on mental health problems (i...
January 6, 2023: Journal of Nursing Scholarship
https://read.qxmd.com/read/36581598/imbalance-in-the-spinal-serotonergic-pathway-induces-aggravation-of-mechanical-allodynia-and-microglial-activation-in-carrageenan-inflammation
#23
JOURNAL ARTICLE
Junxiu Jin, Dong Ho Kang, Jin Jeon, Hyung Gon Lee, Woong Mo Kim, Myung Ha Yoon, Jeong Il Choi
BACKGROUND: This study investigated the effect of an excess and a deficit of spinal 5-hydroxytryptamine (5-HT) on the mechanical allodynia and neuroglia activation in a rodent pain model of carrageenan inflammation. METHODS: Male Sprague-Dawley rats were implanted with an intrathecal (i.t.) catheter to administer the drug. To induce an excess or deficit of 5-HT in the spinal cord, animals were given either three i.t. 5-HT injections at 24-hour intervals or a single i...
January 1, 2023: Korean Journal of Pain
https://read.qxmd.com/read/36507578/behavioral-and-axon-histomorphometric-analyses-after-intraneural-transplantation-of-human-skin-and-nerve-derived-schwann-cells-in-nude-rats
#24
JOURNAL ARTICLE
Tak-Ho Chu, Rajiv Midha
INTRODUCTION/AIMS: We have recently isolated and expanded skin-derived Schwann cells (Sk-SCs) from human skin and showed that they are largely similar to nerve-derived Schwann cells (N-SCs). Here, we extend our investigation into functional assessments of the nude rats that received human Sk-SCs and N-SCs after intraneural delivery into crushed and decellularized tibial nerve in adult nude rats. METHODS: Sk-SCs, N-SCs, dermal fibroblasts, or control culture medium was injected into the crushed and decellularized tibial nerve using in situ repeated freeze-thaw cycles...
February 2023: Muscle & Nerve
https://read.qxmd.com/read/36427137/a-purine-derivative-containing-an-organoselenium-group-protects-against-memory-impairment-sensitivity-to-nociception-oxidative-damage-and-neuroinflammation-in-a-mouse-model-of-alzheimer-s-disease
#25
JOURNAL ARTICLE
Mikaela Peglow Pinz, Renata Leivas de Oliveira, Caren Aline Ramson da Fonseca, Guilherme Teixeira Voss, Beatriz Pereira da Silva, Luis Fernando Barbosa Duarte, William Borges Domingues, Hadassa Gabriela Ortiz, Anne Suély Pinto Savall, Flavia Carla Meotti, Diego Alves, Vinicius Farias Campos, Simone Pinton, Ethel Antunes Wilhelm, Cristiane Luchese
In the present study, the effect of 6-((4-fluorophenyl) selanyl)-9H-purine (FSP) was tested against memory impairment and sensitivity to nociception induced by intracerebroventricular injection of amyloid-beta peptide (Aβ) (25-35 fragment), 3 nmol/3 μl/per site in mice. Memory impairment was determined by the object recognition task (ORT) and nociception by the Von-Frey test (VFT). Aβ caused neuroinflammation with upregulation of glial fibrillary acidic protein (GFAP) (in hippocampus), nuclear factor-κB (NF-κB), and the proinflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) in cerebral cortex and hippocampus...
November 24, 2022: Molecular Neurobiology
https://read.qxmd.com/read/36291564/functional-gait-assessment-using-manual-semi-automated-and-deep-learning-approaches-following-standardized-models-of-peripheral-nerve-injury-in-mice
#26
JOURNAL ARTICLE
Daniel Umansky, Kathleen M Hagen, Tak Ho Chu, Rajesh K Pathiyil, Saud Alzahrani, Shalina S Ousman, Rajiv Midha
OBJECTIVE: To develop a standardized model of stretch-crush sciatic nerve injury in mice, and to compare outcomes of crush and novel stretch-crush injuries using standard manual gait and sensory assays, and compare them to both semi-automated as well as deep-learning gait analysis methods. METHODS: Initial studies in C57/Bl6 mice were used to develop crush and stretch-crush injury models followed by histologic analysis. In total, 12 eight-week-old 129S6/SvEvTac mice were used in a six-week behavioural study...
September 23, 2022: Biomolecules
https://read.qxmd.com/read/36175342/spinal-orexin-a-attenuates-opioid-induced-mechanical-hypersensitivity-in-the-rat
#27
JOURNAL ARTICLE
Dong-Ho Youn, Jiyeon Jun, Tae Wan Kim, Kibeom Park
Background: Repeated administration of opioid analgesics for pain treatment can produce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus, this study investigated whether spinally (centrally) administered orexin A attenuates opioid-induced hyperalgesia (OIH). Methods: [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioid receptor agonist, was used to induce mechanical hypersensitivity and was administered intradermally (4 times, 1-hour intervals) on the rat hind paw dorsum...
October 1, 2022: Korean Journal of Pain
https://read.qxmd.com/read/36046031/the-mixture-of-agrimonia-pilosa-ledeb-and-salvia-miltiorrhiza-bunge-extract-produces-analgesic-and-anti-inflammatory-effects-in-a-collagen-induced-arthritis-mouse-model
#28
JOURNAL ARTICLE
Jing Hui Feng, Jeon Sub Jung, Seung Hwan Hwang, Soo Kyeong Lee, Sang Youn Lee, Youn Gil Kwak, Doo-Ho Kim, Chu-Youn Song, Min Jung Kim, Hong Won Suh, Sung Chan Kim, Soon Sung Lim
Pain and inflammation typically manifest in patients with arthritis. It is now widely known that Agrimonia pilosa Ledeb (AP) and Salvia miltiorrhiza Bunge (SM) exert anti-inflammatory and antinociceptive effects. We have previously reported that the mixture extract (ME) from AP and SM produces antinociceptive and anti-inflammatory effects in gout arthritis and monoiodoacetate (MIA)-induced arthritis models. In the present study, we assessed the antinociceptive and anti-inflammatory effects on the collagen-induced arthritis (CIA) model...
2022: Animal Cells and Systems
https://read.qxmd.com/read/36018710/lawson-criterion-for-ignition-exceeded-in-an-inertial-fusion-experiment
#29
JOURNAL ARTICLE
H Abu-Shawareb, R Acree, P Adams, J Adams, B Addis, R Aden, P Adrian, B B Afeyan, M Aggleton, L Aghaian, A Aguirre, D Aikens, J Akre, F Albert, M Albrecht, B J Albright, J Albritton, J Alcala, C Alday, D A Alessi, N Alexander, J Alfonso, N Alfonso, E Alger, S J Ali, Z A Ali, W E Alley, P Amala, P A Amendt, P Amick, S Ammula, C Amorin, D J Ampleford, R W Anderson, T Anklam, N Antipa, B Appelbe, C Aracne-Ruddle, E Araya, M Arend, P Arnold, T Arnold, J Asay, L J Atherton, D Atkinson, R Atkinson, J M Auerbach, B Austin, L Auyang, A S Awwal, J Ayers, S Ayers, T Ayers, S Azevedo, B Bachmann, C A Back, J Bae, D S Bailey, J Bailey, T Baisden, K L Baker, H Baldis, D Barber, M Barberis, D Barker, A Barnes, C W Barnes, M A Barrios, C Barty, I Bass, S H Batha, S H Baxamusa, G Bazan, J K Beagle, R Beale, B R Beck, J B Beck, M Bedzyk, R G Beeler, R G Beeler, W Behrendt, L Belk, P Bell, M Belyaev, J F Benage, G Bennett, L R Benedetti, L X Benedict, R Berger, T Bernat, L A Bernstein, B Berry, L Bertolini, G Besenbruch, J Betcher, R Bettenhausen, R Betti, B Bezzerides, S D Bhandarkar, R Bickel, J Biener, T Biesiada, K Bigelow, J Bigelow-Granillo, V Bigman, R M Bionta, N W Birge, M Bitter, A C Black, R Bleile, D L Bleuel, E Bliss, E Bliss, B Blue, T Boehly, K Boehm, C D Boley, R Bonanno, E J Bond, T Bond, M J Bonino, M Borden, J-L Bourgade, J Bousquet, J Bowers, M Bowers, R Boyd, A Bozek, D K Bradley, K S Bradley, P A Bradley, L Bradley, L Brannon, P S Brantley, D Braun, T Braun, K Brienza-Larsen, T M Briggs, J Britten, E D Brooks, D Browning, M W Bruhn, T A Brunner, H Bruns, G Brunton, B Bryant, T Buczek, J Bude, L Buitano, S Burkhart, J Burmark, A Burnham, R Burr, L E Busby, B Butlin, R Cabeltis, M Cable, W H Cabot, B Cagadas, J Caggiano, R Cahayag, S E Caldwell, S Calkins, D A Callahan, J Calleja-Aguirre, L Camara, D Camp, E M Campbell, J H Campbell, B Carey, R Carey, K Carlisle, L Carlson, L Carman, J Carmichael, A Carpenter, C Carr, J A Carrera, D Casavant, A Casey, D T Casey, A Castillo, E Castillo, J I Castor, C Castro, W Caughey, R Cavitt, J Celeste, P M Celliers, C Cerjan, G Chandler, B Chang, C Chang, J Chang, L Chang, R Chapman, T Chapman, L Chase, H Chen, H Chen, K Chen, L-Y Chen, B Cheng, J Chittenden, C Choate, J Chou, R E Chrien, M Chrisp, K Christensen, M Christensen, A R Christopherson, M Chung, J A Church, A Clark, D S Clark, K Clark, R Clark, L Claus, B Cline, J A Cline, J A Cobble, K Cochrane, B Cohen, S Cohen, M R Collette, G Collins, L A Collins, T J B Collins, A Conder, B Conrad, M Conyers, A W Cook, D Cook, R Cook, J C Cooley, G Cooper, T Cope, S R Copeland, F Coppari, J Cortez, J Cox, D H Crandall, J Crane, R S Craxton, M Cray, A Crilly, J W Crippen, D Cross, M Cuneo, G Cuotts, C E Czajka, D Czechowicz, T Daly, P Danforth, R Darbee, B Darlington, P Datte, L Dauffy, G Davalos, S Davidovits, P Davis, J Davis, S Dawson, R D Day, T H Day, M Dayton, C Deck, C Decker, C Deeney, K A DeFriend, G Deis, N D Delamater, J A Delettrez, R Demaret, S Demos, S M Dempsey, R Desjardin, T Desjardins, M P Desjarlais, E L Dewald, J DeYoreo, S Diaz, G Dimonte, T R Dittrich, L Divol, S N Dixit, J Dixon, E S Dodd, D Dolan, A Donovan, M Donovan, T Döppner, C Dorrer, N Dorsano, M R Douglas, D Dow, J Downie, E Downing, M Dozieres, V Draggoo, D Drake, R P Drake, T Drake, G Dreifuerst, D F DuBois, P F DuBois, G Dunham, R Dylla-Spears, A K L Dymoke-Bradshaw, B Dzenitis, C Ebbers, M Eckart, S Eddinger, D Eder, D Edgell, M J Edwards, P Efthimion, J H Eggert, B Ehrlich, P Ehrmann, S Elhadj, C Ellerbee, N S Elliott, C L Ellison, F Elsner, M Emerich, K Engelhorn, T England, E English, P Epperson, R Epstein, G Erbert, M A Erickson, D J Erskine, A Erlandson, R J Espinosa, C Estes, K G Estabrook, S Evans, A Fabyan, J Fair, R Fallejo, N Farmer, W A Farmer, M Farrell, V E Fatherley, M Fedorov, E Feigenbaum, M Feit, W Ferguson, J C Fernandez, A Fernandez-Panella, S Fess, J E Field, C V Filip, J R Fincke, T Finn, S M Finnegan, R G Finucane, M Fischer, A Fisher, J Fisher, B Fishler, D Fittinghoff, P Fitzsimmons, M Flegel, K A Flippo, J Florio, J Folta, P Folta, L R Foreman, C Forrest, A Forsman, J Fooks, M Foord, R Fortner, K Fournier, D E Fratanduono, N Frazier, T Frazier, C Frederick, M S Freeman, J Frenje, D Frey, G Frieders, S Friedrich, D H Froula, J Fry, T Fuller, J Gaffney, S Gales, B Le Galloudec, K K Le Galloudec, A Gambhir, L Gao, W J Garbett, A Garcia, C Gates, E Gaut, P Gauthier, Z Gavin, J Gaylord, M Geissel, F Génin, J Georgeson, H Geppert-Kleinrath, V Geppert-Kleinrath, N Gharibyan, J Gibson, C Gibson, E Giraldez, V Glebov, S G Glendinning, S Glenn, S H Glenzer, S Goade, P L Gobby, S R Goldman, B Golick, M Gomez, V Goncharov, D Goodin, P Grabowski, E Grafil, P Graham, J Grandy, E Grasz, F Graziani, G Greenman, J A Greenough, A Greenwood, G Gregori, T Green, J R Griego, G P Grim, J Grondalski, S Gross, J Guckian, N Guler, B Gunney, G Guss, S Haan, J Hackbarth, L Hackel, R Hackel, C Haefner, C Hagmann, K D Hahn, S Hahn, B J Haid, B M Haines, B M Hall, C Hall, G N Hall, M Hamamoto, S Hamel, C E Hamilton, B A Hammel, J H Hammer, G Hampton, A Hamza, A Handler, S Hansen, D Hanson, R Haque, D Harding, E Harding, J D Hares, D B Harris, J A Harte, E P Hartouni, R Hatarik, S Hatchett, A A Hauer, M Havre, R Hawley, J Hayes, J Hayes, S Hayes, A Hayes-Sterbenz, C A Haynam, D A Haynes, D Headley, A Heal, J E Heebner, S Heerey, G M Heestand, R Heeter, N Hein, C Heinbockel, C Hendricks, M Henesian, J Heninger, J Henrikson, E A Henry, E B Herbold, M R Hermann, G Hermes, J E Hernandez, V J Hernandez, M C Herrmann, H W Herrmann, O D Herrera, D Hewett, R Hibbard, D G Hicks, D Hill, K Hill, T Hilsabeck, D E Hinkel, D D Ho, V K Ho, J K Hoffer, N M Hoffman, M Hohenberger, M Hohensee, W Hoke, D Holdener, F Holdener, J P Holder, B Holko, D Holunga, J F Holzrichter, J Honig, D Hoover, D Hopkins, L Berzak Hopkins, M Hoppe, M L Hoppe, J Horner, R Hornung, C J Horsfield, J Horvath, D Hotaling, R House, L Howell, W W Hsing, S X Hu, H Huang, J Huckins, H Hui, K D Humbird, J Hund, J Hunt, O A Hurricane, M Hutton, K H-K Huynh, L Inandan, C Iglesias, I V Igumenshchev, N Izumi, M Jackson, J Jackson, S D Jacobs, G James, K Jancaitis, J Jarboe, L C Jarrott, D Jasion, J Jaquez, J Jeet, A E Jenei, J Jensen, J Jimenez, R Jimenez, D Jobe, Z Johal, H M Johns, D Johnson, M A Johnson, M Gatu Johnson, R J Johnson, S Johnson, S A Johnson, T Johnson, K Jones, O Jones, M Jones, R Jorge, H J Jorgenson, M Julian, B I Jun, R Jungquist, J Kaae, N Kabadi, D Kaczala, D Kalantar, K Kangas, V V Karasiev, M Karasik, V Karpenko, A Kasarky, K Kasper, R Kauffman, M I Kaufman, C Keane, L Keaty, L Kegelmeyer, P A Keiter, P A Kellett, J Kellogg, J H Kelly, S Kemic, A J Kemp, G E Kemp, G D Kerbel, D Kershaw, S M Kerr, T J Kessler, M H Key, S F Khan, H Khater, C Kiikka, J Kilkenny, Y Kim, Y-J Kim, J Kimko, M Kimmel, J M Kindel, J King, R K Kirkwood, L Klaus, D Klem, J L Kline, J Klingmann, G Kluth, P Knapp, J Knauer, J Knipping, M Knudson, D Kobs, J Koch, T Kohut, C Kong, J M Koning, P Koning, S Konior, H Kornblum, L B Kot, B Kozioziemski, M Kozlowski, P M Kozlowski, J Krammen, N S Krasheninnikova, B Kraus, W Krauser, J D Kress, A L Kritcher, E Krieger, J J Kroll, W L Kruer, M K G Kruse, S Kucheyev, M Kumbera, S Kumpan, J Kunimune, B Kustowski, T J T Kwan, G A Kyrala, S Laffite, M Lafon, K LaFortune, B Lahmann, B Lairson, O L Landen, J Langenbrunner, L Lagin, T Land, M Lane, D Laney, A B Langdon, S H Langer, A Langro, N E Lanier, T E Lanier, D Larson, B F Lasinski, D Lassle, D LaTray, G Lau, N Lau, C Laumann, A Laurence, T A Laurence, J Lawson, H P Le, R R Leach, L Leal, A Leatherland, K LeChien, B Lechleiter, A Lee, M Lee, T Lee, R J Leeper, E Lefebvre, J-P Leidinger, B LeMire, R W Lemke, N C Lemos, S Le Pape, R Lerche, S Lerner, S Letts, K Levedahl, T Lewis, C K Li, H Li, J Li, W Liao, Z M Liao, D Liedahl, J Liebman, G Lindford, E L Lindman, J D Lindl, H Loey, R A London, F Long, E N Loomis, F E Lopez, H Lopez, E Losbanos, S Loucks, R Lowe-Webb, E Lundgren, A P Ludwigsen, R Luo, J Lusk, R Lyons, T Ma, Y Macallop, M J MacDonald, B J MacGowan, J M Mack, A J Mackinnon, S A MacLaren, A G MacPhee, G R Magelssen, J Magoon, R M Malone, T Malsbury, R Managan, R Mancini, K Manes, D Maney, D Manha, O M Mannion, A M Manuel, E Mapoles, G Mara, T Marcotte, E Marin, M M Marinak, C Mariscal, D A Mariscal, E F Mariscal, E V Marley, J A Marozas, R Marquez, C D Marshall, F J Marshall, M Marshall, S Marshall, J Marticorena, D Martinez, I Maslennikov, D Mason, R J Mason, L Masse, W Massey, P-E Masson-Laborde, N D Masters, D Mathisen, E Mathison, J Matone, M J Matthews, C Mattoon, T R Mattsson, K Matzen, C W Mauche, M Mauldin, T McAbee, M McBurney, T Mccarville, R L McCrory, A M McEvoy, C McGuffey, M Mcinnis, P McKenty, M S McKinley, J B McLeod, A McPherson, B Mcquillan, M Meamber, K D Meaney, N B Meezan, R Meissner, T A Mehlhorn, N C Mehta, J Menapace, F E Merrill, B T Merritt, E C Merritt, D D Meyerhofer, S Mezyk, R J Mich, P A Michel, D Milam, C Miller, D Miller, D S Miller, E Miller, E K Miller, J Miller, M Miller, P E Miller, T Miller, W Miller, V Miller-Kamm, M Millot, J L Milovich, P Minner, J-L Miquel, S Mitchell, K Molvig, R C Montesanti, D S Montgomery, M Monticelli, A Montoya, J D Moody, A S Moore, E Moore, M Moran, J C Moreno, K Moreno, B E Morgan, T Morrow, J W Morton, E Moses, K Moy, R Muir, M S Murillo, J E Murray, J R Murray, D H Munro, T J Murphy, F M Munteanu, J Nafziger, T Nagayama, S R Nagel, R Nast, R A Negres, A Nelson, D Nelson, J Nelson, S Nelson, S Nemethy, P Neumayer, K Newman, M Newton, H Nguyen, J-M G Di Nicola, P Di Nicola, C Niemann, A Nikroo, P M Nilson, A Nobile, V Noorai, R Nora, M Norton, M Nostrand, V Note, S Novell, P F Nowak, A Nunez, R A Nyholm, M O'Brien, A Oceguera, J A Oertel, J Okui, B Olejniczak, J Oliveira, P Olsen, B Olson, K Olson, R E Olson, Y P Opachich, N Orsi, C D Orth, M Owen, S Padalino, E Padilla, R Paguio, S Paguio, J Paisner, S Pajoom, A Pak, S Palaniyappan, K Palma, T Pannell, F Papp, D Paras, T Parham, H-S Park, A Pasternak, S Patankar, M V Patel, P K Patel, R Patterson, S Patterson, B Paul, M Paul, E Pauli, O T Pearce, J Pearcy, B Pedrotti, A Peer, L J Pelz, B Penetrante, J Penner, A Perez, L J Perkins, E Pernice, T S Perry, S Person, D Petersen, T Petersen, D L Peterson, E B Peterson, J E Peterson, J L Peterson, K Peterson, R R Peterson, R D Petrasso, F Philippe, T J Phipps, E Piceno, Y Ping, L Pickworth, J Pino, R Plummer, G D Pollack, S M Pollaine, B B Pollock, D Ponce, J Ponce, J Pontelandolfo, J L Porter, J Post, O Poujade, C Powell, H Powell, G Power, M Pozulp, M Prantil, M Prasad, S Pratuch, S Price, K Primdahl, S Prisbrey, R Procassini, A Pruyne, B Pudliner, S R Qiu, K Quan, M Quinn, J Quintenz, P B Radha, F Rainer, J E Ralph, K S Raman, R Raman, P Rambo, S Rana, A Randewich, D Rardin, M Ratledge, N Ravelo, F Ravizza, M Rayce, A Raymond, B Raymond, B Reed, C Reed, S Regan, B Reichelt, V Reis, S Reisdorf, V Rekow, B A Remington, A Rendon, W Requieron, M Rever, H Reynolds, J Reynolds, J Rhodes, M Rhodes, M C Richardson, B Rice, N G Rice, R Rieben, A Rigatti, S Riggs, H G Rinderknecht, K Ring, B Riordan, R Riquier, C Rivers, D Roberts, V Roberts, G Robertson, H F Robey, J Robles, P Rocha, G Rochau, J Rodriguez, S Rodriguez, M Rosen, M Rosenberg, G Ross, J S Ross, P Ross, J Rouse, D Rovang, A M Rubenchik, M S Rubery, C L Ruiz, M Rushford, B Russ, J R Rygg, B S Ryujin, R A Sacks, R F Sacks, K Saito, T Salmon, J D Salmonson, J Sanchez, S Samuelson, M Sanchez, C Sangster, A Saroyan, J Sater, A Satsangi, S Sauers, R Saunders, J P Sauppe, R Sawicki, D Sayre, M Scanlan, K Schaffers, G T Schappert, S Schiaffino, D J Schlossberg, D W Schmidt, M J Schmitt, D H G Schneider, M B Schneider, R Schneider, M Schoff, M Schollmeier, M Schölmerich, C R Schroeder, S E Schrauth, H A Scott, I Scott, J M Scott, R H H Scott, C R Scullard, T Sedillo, F H Seguin, W Seka, J Senecal, S M Sepke, L Seppala, K Sequoia, J Severyn, J M Sevier, N Sewell, S Seznec, R C Shah, J Shamlian, D Shaughnessy, M Shaw, R Shaw, C Shearer, R Shelton, N Shen, M W Sherlock, A I Shestakov, E L Shi, S J Shin, N Shingleton, W Shmayda, M Shor, M Shoup, C Shuldberg, L Siegel, F J Silva, A N Simakov, B T Sims, D Sinars, P Singh, H Sio, K Skulina, S Skupsky, S Slutz, M Sluyter, V A Smalyuk, D Smauley, R M Smeltser, C Smith, I Smith, J Smith, L Smith, R Smith, R Sohn, S Sommer, C Sorce, M Sorem, J M Soures, M L Spaeth, B K Spears, S Speas, D Speck, R Speck, J Spears, T Spinka, P T Springer, M Stadermann, B Stahl, J Stahoviak, L G Stanton, R Steele, W Steele, D Steinman, R Stemke, R Stephens, S Sterbenz, P Sterne, D Stevens, J Stevers, C B Still, C Stoeckl, W Stoeffl, J S Stolken, C Stolz, E Storm, G Stone, S Stoupin, E Stout, I Stowers, R Strauser, H Streckart, J Streit, D J Strozzi, T Suratwala, G Sutcliffe, L J Suter, S B Sutton, V Svidzinski, G Swadling, W Sweet, A Szoke, M Tabak, M Takagi, A Tambazidis, V Tang, M Taranowski, L A Taylor, S Telford, W Theobald, M Thi, A Thomas, C A Thomas, I Thomas, R Thomas, I J Thompson, A Thongstisubskul, C B Thorsness, G Tietbohl, R E Tipton, M Tobin, N Tomlin, R Tommasini, A J Toreja, J Torres, R P J Town, S Townsend, J Trenholme, A Trivelpiece, C Trosseille, H Truax, D Trummer, S Trummer, T Truong, D Tubbs, E R Tubman, T Tunnell, D Turnbull, R E Turner, M Ulitsky, R Upadhye, J L Vaher, P VanArsdall, D VanBlarcom, M Vandenboomgaerde, R VanQuinlan, B M Van Wonterghem, W S Varnum, A L Velikovich, A Vella, C P Verdon, B Vermillion, S Vernon, R Vesey, J Vickers, R M Vignes, M Visosky, J Vocke, P L Volegov, S Vonhof, R Von Rotz, H X Vu, M Vu, D Wall, J Wall, R Wallace, B Wallin, D Walmer, C A Walsh, C F Walters, C Waltz, A Wan, A Wang, Y Wang, J S Wark, B E Warner, J Watson, R G Watt, P Watts, J Weaver, R P Weaver, S Weaver, C R Weber, P Weber, S V Weber, P Wegner, B Welday, L Welser-Sherrill, K Weiss, K Widmann, G F Wheeler, W Whistler, R K White, H D Whitley, P Whitman, M E Wickett, C Widmayer, J Wiedwald, R Wilcox, S Wilcox, C Wild, B H Wilde, C H Wilde, K Wilhelmsen, M D Wilke, H Wilkens, P Wilkins, S C Wilks, E A Williams, G J Williams, W Williams, W H Williams, D C Wilson, B Wilson, E Wilson, R Wilson, S Winters, J Wisoff, M Wittman, J Wolfe, A Wong, K W Wong, L Wong, N Wong, R Wood, D Woodhouse, J Woodruff, D T Woods, S Woods, B N Woodworth, E Wooten, A Wootton, K Work, J B Workman, J Wright, M Wu, C Wuest, F J Wysocki, H Xu, M Yamaguchi, B Yang, S T Yang, J Yatabe, C B Yeamans, B C Yee, S A Yi, L Yin, B Young, C S Young, C V Young, P Young, K Youngblood, R Zacharias, G Zagaris, N Zaitseva, F Zaka, F Ze, B Zeiger, M Zika, G B Zimmerman, T Zobrist, J D Zuegel, A B Zylstra
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain...
August 12, 2022: Physical Review Letters
https://read.qxmd.com/read/36004538/prediction-of-depression-treatment-outcome-from-multimodal-data-a-can-bind-1-report
#30
JOURNAL ARTICLE
Mehri Sajjadian, Rudolf Uher, Keith Ho, Stefanie Hassel, Roumen Milev, Benicio N Frey, Faranak Farzan, Pierre Blier, Jane A Foster, Sagar V Parikh, Daniel J Müller, Susan Rotzinger, Claudio N Soares, Gustavo Turecki, Valerie H Taylor, Raymond W Lam, Stephen C Strother, Sidney H Kennedy
BACKGROUND: Prediction of treatment outcomes is a key step in improving the treatment of major depressive disorder (MDD). The Canadian Biomarker Integration Network in Depression (CAN-BIND) aims to predict antidepressant treatment outcomes through analyses of clinical assessment, neuroimaging, and blood biomarkers. METHODS: In the CAN-BIND-1 dataset of 192 adults with MDD and outcomes of treatment with escitalopram, we applied machine learning models in a nested cross-validation framework...
August 25, 2022: Psychological Medicine
https://read.qxmd.com/read/35725384/frozen-vein-wrapping-for-chronic-nerve-constriction-injury-reduces-sciatic-nerve-allodynia-in-a-rat-model
#31
JOURNAL ARTICLE
Michiaki Mukai, Kentaro Uchida, Naoya Hirosawa, Kenichi Murakami, Gen Inoue, Masayuki Miyagi, Yasuhiro Shiga, Hiroyuki Sekiguchi, Kazuhide Inage, Sumihisa Orita, Takane Suzuki, Yusuke Matsuura, Masashi Takaso, Seiji Ohtori
BACKGROUND: Autologous vein wrapping (VW) is used in the treatment of recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, use of autologous veins is limited by the inability to obtain longer veins of sufficient length for larger sites. Frozen allograft tissue has several advantages, including its availability for large grafts, avoidance of donor-site morbidity, and shorter operation time. Here, we investigated the effect of frozen vein wrapping (FVW) in Wistar rats as a model of sciatic nerve injury...
June 20, 2022: BMC Neuroscience
https://read.qxmd.com/read/35685245/ameliorative-potential-of-hot-compress-on-sciatic-nerve-pain-in-chronic-constriction-injury-induced-rat-model
#32
JOURNAL ARTICLE
Kwan-Yu Chan, Wen-Ching Tsai, Chien-Yi Chiang, Meei-Ling Sheu, Chih-Yang Huang, Yi-Ching Tsai, Chia-Yun Tsai, Chia-Jung Lu, Zih-Ping Ho, De-Wei Lai
Hot compress modalities are used to ameliorate pain despite prevalent confusion about which modality should be used and when. Most recommendations for hot compresses are based on empirical experience, with limited evidence to support its efficacy. To obtain insight into the nerve transmission mechanism of hot compresses and to identify the nerve injury marker proteins specifically associated with sciatic nerve pain, we established a rat model of chronic constriction injury (CCI) and performed mechanical allodynia, electrophysiology, and histopathological analysis...
2022: Frontiers in Synaptic Neuroscience
https://read.qxmd.com/read/35546043/males-and-females-differ-in-reported-sexual-functioning-with-escitalopram-treatment-for-major-depressive-disorder-a-can-bind-1-study-report
#33
JOURNAL ARTICLE
Caroline W Espinola, Yuelee Khoo, Roohie Parmar, Ilya Demchenko, Benicio N Frey, Roumen V Milev, Arun V Ravindran, Sagar V Parikh, Keith Ho, Susan Rotzinger, Wendy Lou, Raymond W Lam, Sidney H Kennedy, Venkat Bhat
BACKGROUND: Antidepressant use for major depressive disorder (MDD) is frequently associated with sexual dysfunction. AIMS: Cross-sectional and longitudinal relationships between antidepressant treatment outcomes and sexual functioning (SF) were evaluated separately for males and females receiving escitalopram. We further assessed the association between pre- and posttreatment SF. METHODS: In all, 208 of the 211 CAN-BIND-1 trial participants (77 males and 131 females) with MDD and detectable drug blood levels were eligible for the analyses...
May 2022: Journal of Psychopharmacology
https://read.qxmd.com/read/35333448/pretreatment-anxious-depression-as-a-predictor-of-side-effect-frequency-and-severity-in-escitalopram-and-aripiprazole-adjunctive-therapy
#34
JOURNAL ARTICLE
Caroline W Espinola, Yuelee Khoo, Roohie Parmar, Ilya Demchenko, Benicio N Frey, Roumen V Milev, Arun V Ravindran, Sagar V Parikh, Keith Ho, Susan Rotzinger, Wendy Lou, Raymond W Lam, Sidney H Kennedy, Venkat Bhat
OBJECTIVE: To report side effect frequency and severity in patients with major depressive disorder (MDD) receiving escitalopram and aripiprazole adjunctive therapy and to examine whether pretreatment anxious depression is associated with the number and presence of specific side effects. METHODS: 188 of the 211 trial participants provided information on side effects during treatment with escitalopram (10-20 mg) for 8 weeks, and nonresponders received further augmentation on aripiprazole (2-10 mg) adjunctive therapy for another 8 weeks, whereas responders remained on escitalopram...
March 25, 2022: Brain and Behavior
https://read.qxmd.com/read/35062462/a-fully-implantable-miniaturized-liquid-crystal-polymer-lcp-based-spinal-cord-stimulator-for-pain-control
#35
JOURNAL ARTICLE
Seunghyeon Yun, Chin Su Koh, Jungmin Seo, Shinyong Shim, Minkyung Park, Hyun Ho Jung, Kyungsik Eom, Jin Woo Chang, Sung June Kim
Spinal cord stimulation is a therapy to treat the severe neuropathic pain by suppressing the pain signal via electrical stimulation of the spinal cord. The conventional metal packaged and battery-operated implantable pulse generator (IPG) produces electrical pulses to stimulate the spinal cord. Despite its stable operation after implantation, the implantation site is limited due to its bulky size and heavy weight. Wireless communications including wireless power charging is also restricted, which is mainly attributed to the electromagnetic shielding of the metal package...
January 10, 2022: Sensors
https://read.qxmd.com/read/35051779/periaqueductal-gray-is-required-for-controlling-chronic-stress-induced-depression-like-behavior
#36
JOURNAL ARTICLE
Wei-Hao Peng, Hung-Wei Kan, Yu-Cheng Ho
BACKGROUND: Enduring exposure to psychological stress is associated with an elevated risk of major depressive disorder (MDD). There is an enormous need to investigate the unexplored mechanisms of MDD. We examined whether pain-free stress alters synaptic transmission, causing depression-like behaviors in the ventrolateral periaqueductal gray (vlPAG), a brain stem nucleus that controls stress-related depression-like behavior. METHODS: In the current study, we studied neuronal changes in the vlPAG and behavioral transforms using electrophysiological recordings, behavioral tests, and pharmacological approaches...
February 19, 2022: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/34986035/-one-degree-of-separation-a-mixed-methods-evaluation-of-canadian-mental-health-care-user-and-provider-experiences-with-remote-care-during-covid-19
#37
JOURNAL ARTICLE
Amanda K Ceniti, Wegdan R Abdelmoemin, Keith Ho, Yudi Kang, Franca Placenza, Rachel Laframboise, Venkat Bhat, Jane A Foster, Benicio N Frey, Raymond W Lam, Roumen Milev, Susan Rotzinger, Claudio N Soares, Rudolf Uher, Sidney H Kennedy
OBJECTIVES: The COVID-19 pandemic has contributed to a shift from in-person to remote mental health care. While remote care methods have long existed, their widespread use is unprecedented. There is little research about mental health care user and provider experiences with this transition, and no published studies to date have compared satisfaction between these groups. METHODS: Canadian mental health care users ( n  = 332) and providers ( n  = 107) completed an online self-report survey from October 2020 to February 2021 hosted by the Canadian Biomarker Integration Network in Depression...
September 2022: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://read.qxmd.com/read/34921820/baseline-anxiety-and-early-anxiety-depression-improvement-in-anxious-depression-predicts-treatment-outcomes-with-escitalopram-a-can-bind-1-study-report
#38
JOURNAL ARTICLE
Yuelee Khoo, Ilya Demchenko, Benicio N Frey, Roumen V Milev, Arun V Ravindran, Sagar V Parikh, Keith Ho, Susan Rotzinger, Wendy Lou, Raymond W Lam, Sidney H Kennedy, Venkat Bhat
INTRODUCTION: Although anxiety symptoms frequently co-occur with major depressive disorder, few studies examined the prediction of treatment outcomes among participants with anxious depression receiving antidepressants. We investigated whether baseline anxiety, and early improvements in anxiety and depression symptoms predict eventual treatment outcomes. METHODS: 111 participants with anxious depression, defined using ≥ 10 on GAD-7, received escitalopram (10-20 mg) for 8 weeks...
March 1, 2022: Journal of Affective Disorders
https://read.qxmd.com/read/34838749/the-active-von-frey-filament-test-a-new-technique-to-evaluate-hand-tactile-sensation-in-continuous-variable-units
#39
JOURNAL ARTICLE
Jong Woo Kang, Hyun-Joo Lee, Jong-Gyeong Lee, Dong-Hoon Oh, Junghoon Kim, Ji-Woon Lee, In-Ho Jeon, Youngjin Choi
The von Frey filament test (vF) is a mainstay of clinical examination. However, its results can be affected by touch speed and other potentially confounding factors. Moreover, the differences between two adjacent filament levels are too large to detect subtle changes. Active vF (AvF) was developed to induce in-depth sensory change. The present study hypothesized that AvF produces different patterns of fingertip sensation; consequently, it could be used as a new assessment tool for neural impairment. The aim of the study was to provide preliminary normative comparative vF and AvF data...
November 24, 2021: Hand Surgery and Rehabilitation
https://read.qxmd.com/read/34798366/proposal-of-a-subtype-of-serovar-4-k4b-o3-of-actinobacillus-pleuropneumoniae-based-on-serological-and-genotypic-analysis
#40
JOURNAL ARTICLE
Ho To, Michiha Kon, Fumiko Koike, Kazumoto Shibuya, Shinya Nagai, Marcelo Gottschalk, Joachim Frey, Chihiro Sasakawa
The aim of this study was to investigate an isolate of Actinobacillus pleuropneumoniae, named 14-760, which was serologically not classifiable among the recognised serovars of A. pleuropneumoniae. It reacted with the antisera raised against serovars 3, 6, 8, 15 and 17 in the agar gel precipitation (AGP) test, and was positive in the capsular serovar 4-specific PCR (cps4B PCR) assay. The isolate contains a type II capsule locus similar to serovar 4 but with variations in the length of four intergeneric regions (modF-cpxA, cpxD-cpsA, cpsC-a 114 bp orf, and lysA-ydeN), and three gene sequences (modF, cpsC and ydeN)...
December 2021: Veterinary Microbiology
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