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https://www.readbyqxmd.com/read/28736826/impact-of-respiratory-motion-and-acquisition-settings-on-spect-liver-dosimetry-for-radioembolization
#1
Remco Bastiaannet, Max A Viergever, Hugo W A M de Jong
PURPOSE: Respiratory motion may impose significant inaccuracies on emission activity estimation in quantitative SPECT. This effect may be a major issue in dosimetry as used in management of liver radioembolization. The purpose of this study was to investigate the impact of respiratory motion on radioembolization liver dosimetry for different SPECT acquisition settings. METHODS: In a series of SPECT/CT Monte Carlo simulations using several digital XCAT phantoms, the following parameters were varied: breathing/non-breathing, liver tumor size (0...
July 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28734644/postmastectomy-radiation-therapy-technique-and-cardiopulmonary-sparing-a-dosimetric-comparative-analysis-between-photons-and-protons-with-free-breathing-versus-deep-inspiration-breath-hold
#2
Sagar A Patel, Hsiao-Ming Lu, Jacqueline A Nyamwanda, Rachel B Jimenez, Alphonse G Taghian, Shannon M MacDonald, Nicolas Depauw
PURPOSE: Dosimetric studies have suggested greater cardiopulmonary sparing with protons over photons for left-sided postmastectomy radiation therapy (PMRT). Modern techniques such as deep inspiration breath hold (DIBH) can help spare the heart. This analysis compares photon and proton delivery with and without DIBH. METHODS AND MATERIALS: Ten women with left breast cancer referred for PMRT on a prospective clinical trial with unfavorable cardiac anatomy underwent free breathing (FB) and DIBH computed tomography simulation...
June 21, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28727649/variables-affecting-intra-abdominal-pressure-during-lifting-in-the-early-postpartum-period
#3
Yvonne Hsu, Robert Hitchcock, Stefan Niederauer, Ingrid E Nygaard, Janet M Shaw, Xiaoming Sheng
OBJECTIVES: Intra-abdominal pressure (IAP) may contribute to pelvic floor health, although the direction and magnitude of such an effect, if any, are not yet known. Identifying individual characteristics, and in particular modifiable factors, associated with higher IAP during recovery from vaginal childbirth might serve to mitigate early pelvic floor dysfunction. The aim of this study was to identify characteristics associated with maximal IAP during lifting in postpartum primiparous women who delivered vaginally...
July 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28721046/brain-metabolite-values-in-children-with-breath-holding-spells
#4
Mustafa Calik, Dilek Sen Dokumaci, Suna Sarikaya, Mahmut Demir, Ilhan Isik, Halil Kazanasmaz, Cemil Kaya, Hasan Kandemir
Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28720085/my-child-cannot-breathe-while-sleeping-a-report-of-three-cases-and-review
#5
Won Hee Seo, Minkyu Park, So-Hee Eun, Seonkyeong Rhie, Dae Jin Song, Kyu-Young Chae
BACKGROUND: Sudden breath-holding episodes during sleep in young children are potentially related to sudden infant death syndrome and other life-threatening events. Additionally, these episodes can negatively affect child's growth and development. CASE PRESENTATION: Here, we present 3 cases of preschool children with similar paroxysmal nocturnal waking events associated with choking that had different etiologies (nocturnal frontal lobe epilepsy, nocturnal gastroesophageal reflux disease, and parasomnia, respectively)...
July 18, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28718049/good-things-in-small-packages-an-innovative-delivery-approach-for-inhaled-insulin
#6
James B Fink, Lisa Molloy, John S Patton, Valdecir Castor Galindo-Filho, Jacqueline de Melo Barcelar, Luciana Alcoforado, Simone Cristina Soares Brandão, Armèle Dornelas de Andrade
PURPOSE: The design development of a small, hand held, battery operated, breath actuated inhaler as a drug/device platform for inhaled insulin posed a number of technical challenges. Our goal was to optimize lung deposition and distribution with aerosol generators producing 3-6 μm particle size distribution. METHODS: In silico modeling with computational fluid dynamics (CFD) and in vitro testing of device components were assessed using an Alberta idealized adult airway (Copley, UK) to optimize mouthpiece and aerosol path design for dose delivered distal to the trachea...
July 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28712815/asymptomatic-carotid-stenosis-is-associated-with-cognitive%C3%A2-impairment
#7
Brajesh K Lal, Moira C Dux, Siddhartha Sikdar, Carly Goldstein, Amir A Khan, John Yokemick, Limin Zhao
BACKGROUND: Cerebrovascular risk factors (eg, hypertension, coronary artery disease) and stroke can lead to vascular cognitive impairment. The Asymptomatic Carotid Stenosis and Cognitive Function study evaluated the isolated impact of asymptomatic carotid stenosis (no prior ipsilateral or contralateral stroke or transient ischemic attack) on cognitive function. Cerebrovascular hemodynamic and carotid plaque characteristics were analyzed to elucidate potential mechanisms affecting cognition...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28712715/split-vmat-technique-to-control-the-expiratory-breath-hold-time-in-liver-stereotactic-body-radiation-therapy
#8
Yen Hwa Lin, Shuichi Ozawa, Hideharu Miura, Katsunori Yogo, Takeo Nakashima, Kentaro Miki, Shintaro Tsuda, Yusuke Ochi, Daisuke Kawahara, Tomoki Kimura, Akito Saito, Yasushi Nagata
PURPOSE: In this study, we demonstrate the feasibility of using split-arcs in volumetric modulated arc therapy (VMAT), tailored for expiratory breath-hold in stereotactic body radiation therapy (SBRT) for liver tumors. We compare it with three-dimensional conformal radiation therapy (3D-CRT) and continuous-VMAT, for ten randomly selected hepatocellular carcinoma cases. METHODS: Four coplanar and four non-coplanar beams were used for the 3D-CRT plans. A pair of partial arcs, chosen using a back-and-forth rotating motion, were used for the continuous-VMAT plans...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28708735/evaluation-and-minimization-of-the-pseudohepatic-anisotropy-artifact-in-liver-intravoxel-incoherent-motion
#9
Oi Lei Wong, Gladys Goh Lo, Jing Yuan, Wai Kit Chung, Wing Hung Benny Ho, Michael D Noseworthy
PURPOSE: The aim of this study was to evaluate the effect of the pseudohepatic anisotropy artifact on liver intravoxel incoherent motion (IVIM) metrics and whether the use of multiple gradient directions in the IVIM acquisition minimizes the artifact. MATERIALS AND METHODS: Multiple breath-holding and forced shallow free-breathing IVIM scans were performed on 8 healthy volunteers using 1 and 6 gradient directions. Cluster analysis was carried out to separate motion-contaminated parenchyma from liver parenchyma and vessels...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28706921/computer-tomography-guided-lung-biopsy-using-interactive-breath-hold-control-a-randomized-study
#10
Haseem Ashraf, Shella Krag-Andersen, Matiullah Naqibullah, Valentina Minddal, Annette Nørgaard, Therese Maria Henriette Naur, Peter Sand Myschetzky, Paul Frost Clementsen
BACKGROUND: Interactive breath-hold control (IBC) may improve the accuracy and decrease the complication rate of computed tomography (CT)-guided lung biopsy, but this presumption has not been proven in a randomized study. METHODS: Patients admitted for CT-guided lung biopsy were randomized to biopsy either with (N=201) or without (N=206) IBC. Biopsy accuracy, procedure time, radiation, and complications were compared in the two groups. Predictors for pneumothorax were analyzed...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28705925/management-of-hiccups-in-palliative-care-patients
#11
REVIEW
Yong Suk Jeon, Alison Mary Kearney, Peter Graham Baker
Persistent hiccups are a frustrating experience for palliative care patients, and can have a profound impact on their quality of life. This article provides an evidence-based approach overview of the causes and treatment of this not infrequently debilitating condition for such patients, with a management algorithm. In situations where no readily reversible cause is identified, or where simple physical manoeuvres, such as breath holding have failed, a systematic approach is required. Hiccups can be broadly divided into central and peripheral types...
July 13, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28701900/selection-of-patients-with-left-breast-cancer-for-deep-inspiration-breath-hold-radiotherapy-technique-results-of-a-prospective-study
#12
Beata Czeremszyńska, Stanisław Drozda, Michał Górzyński, Lucyna Kępka
AIM: To assess prospectively which patients with left breast cancer have the dosimetric benefit from the use of deep-inspiration breath-hold radiotherapy (DIBH-RT). BACKGROUND: Improvement in selection of patients for DIBH-RT would spare time of radiotherapy staff by removing the need for preparation of two comparative treatment plans. MATERIALS AND METHODS: Thirty-one patients qualified for whole left breast irradiation underwent breath-hold training and their free-breathing (FB) and DIBH planning-CT were included in the analysis of dosimetric outcome...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28695398/variable-slice-thickness-vast-epi-for-the-reduction-of-susceptibility-artifacts-in-whole-brain-ge-epi-at-7-tesla
#13
Sascha Brunheim, Sören Johst, Viktor Pfaffenrot, Stefan Maderwald, Harald H Quick, Benedikt A Poser
OBJECTIVE: A new technique for 2D gradient-recalled echo echo-planar imaging (GE-EPI) termed 'variable slice thickness' (VAST) is proposed, which reduces signal losses caused by through-slice susceptibility artifacts, while keeping the volume repetition time (TR) manageable. The slice thickness is varied across the brain, with thinner slices being used in the inferior brain regions where signal voids are most severe. MATERIALS AND METHODS: Various axial slice thickness schemes with identical whole-brain coverage were compared to regular EPI, which may either suffer from unfeasibly long TR if appropriately thin slices are used throughout, or signal loss if no counter-measures are taken...
July 10, 2017: Magma
https://www.readbyqxmd.com/read/28689221/variable-refocusing-flip-angle-single-shot-fast-spin-echo-imaging-of-liver-lesions-increased-speed-and-lesion-contrast
#14
Robert M Hicks, Andreas M Loening, Michael A Ohliger, Shreyas S Vasanawala, Thomas A Hope
PURPOSE: To evaluate acquisition time and clinical image quality of a variable refocusing flip angle (vrf) single-shot fast spin echo (SSFSE) sequence in comparison with a conventional SSFSE sequence for imaging of liver lesions in patients undergoing whole-body PET/MRI for oncologic staging. METHODS: A vrfSSFSE sequence was acquired in 43 patients with known pancreatic neuroendocrine tumors undergoing (68)Ga-DOTA-TOC PET on a simultaneous time-of-flight 3.0T PET/MRI...
July 8, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28688951/non-contrast-enhanced-3d-mr-portography-within-a-breath-hold-using-compressed-sensing-acceleration-a-prospective-noninferiority-study
#15
Ayako Ono, Shigeki Arizono, Koji Fujimoto, Thai Akasaka, Rikiya Yamashita, Akihiro Furuta, Hiroyoshi Isoda, Kaori Togashi
PURPOSE: To evaluate images of non-contrast-enhanced 3D MR portography within a breath-hold (BH) using compressed sensing (CS) compared to standard respiratory-triggered (RT) sequences. MATERIALS AND METHODS: Fifty-nine healthy volunteers underwent MR portography using two sequences of balanced steady-state free-precession (bSSFP) with time-spatial labeling inversion pulses (Time-SLIP): BH bSSFP-CS and RT bSSFP. Two radiologists independently scored the diagnostic acceptability to delineate the portal branches (MPV: main portal vein; RPV: right portal vein; LPV: left portal vein; RPPV: right posterior portal vein; and P4 and P8: portal branch of segment 4 and segment 8, respectively) and the overall image quality on a four-point scale...
July 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28679324/breath-hold-black-blood-t1rho-mapping-improves-liver-t1rho-quantification-in-healthy-volunteers
#16
Yì Xiáng J Wáng, Min Deng, Gladys G Lo, Dong Liang, Jing Yuan, Weitian Chen
Background Recent researches suggest that T1rho may be a non-invasive and quantitative technique for detecting and grading liver fibrosis. Purpose To compare a multi-breath-hold bright-blood fast gradient echo (GRE) imaging and a single breath-hold single-shot fast spin echo (FSE) imaging with black-blood effect for liver parenchyma T1rho measurement and to study liver physiological T1rho value in healthy volunteers. Material and Methods The institutional Ethics Committee approved this study. 28 healthy participants (18 men, 10 women; age = 29...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28664753/atypical-cyanotic-breath-holding-spells-in-an-infant-with-16p11-2-microdeletion-syndrome
#17
Jayalakshmi Bhat, Jose Martinez, Paul Maertens
No abstract text is available yet for this article.
June 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28662717/nonenhanced-mr-angiography-of-the-pulmonary-arteries-using-single-shot-radial-quiescent-interval-slice-selective-qiss-a-technical-feasibility-study
#18
Robert R Edelman, Robert I Silvers, Kiran H Thakrar, Mark D Metzl, Jose Nazari, Shivraman Giri, Ioannis Koktzoglou
BACKGROUND: For evaluation of the pulmonary arteries in patients suspected of pulmonary embolism, CT angiography (CTA) is the first-line imaging test with contrast-enhanced MR angiography (CEMRA) a potential alternative. Disadvantages of CTA include exposure to ionizing radiation and an iodinated contrast agent, while CEMRA is sensitive to respiratory motion and requires a gadolinium-based contrast agent. The primary goal of our technical feasibility study was to evaluate pulmonary arterial conspicuity using breath-hold and free-breathing implementations of a recently-developed nonenhanced approach, single-shot radial quiescent-interval slice-selective (QISS) MRA...
June 30, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28662061/ultra-high-field-upper-extremity-peripheral-nerve-and-non-contrast-enhanced-vascular-imaging
#19
Shailesh B Raval, Cynthia A Britton, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay S Gorantla, Tamer S Ibrahim
OBJECTIVE: The purpose of this study was to explore the efficacy of Ultra-high field [UHF] 7 Tesla [T] MRI as compared to 3T MRI in non-contrast enhanced [nCE] imaging of structural anatomy in the elbow, forearm, and hand [upper extremity]. MATERIALS AND METHOD: A wide range of sequences including T1 weighted [T1] volumetric interpolate breath-hold exam [VIBE], T2 weighted [T2] double-echo steady state [DESS], susceptibility weighted imaging [SWI], time-of-flight [TOF], diffusion tensor imaging [DTI], and diffusion spectrum imaging [DSI] were optimized and incorporated with a radiofrequency [RF] coil system composed of a transverse electromagnetic [TEM] transmit coil combined with an 8-channel receive-only array for 7T upper extremity [UE] imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28657201/comparison-of-low-and-ultra-low-dose-computed-tomography-protocols-for-quantitative-lung-and-airway-assessment
#20
Emily Hammond, Chelsea Sloan, John D Newell, Jered P Sieren, Melissa Saylor, Craig Vidal, Shayna Hogue, Frank De Stefano, Alexa Sieren, Eric A Hoffman, Jessica C Sieren
PURPOSE: Quantitative computed tomography (CT) measures are increasingly being developed and used to characterize lung disease. With recent advances in CT technologies, we sought to evaluate the quantitative accuracy of lung imaging at low and ultra-low radiation doses with the use of iterative reconstruction (IR), tube current modulation (TCM), and spectral shaping. METHODS: We investigated the effect of five independent CT protocols reconstructed with IR on quantitative airway measures and global lung measures using an in-vivo large animal model as a human subject surrogate...
June 28, 2017: Medical Physics
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