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https://www.readbyqxmd.com/read/29025407/severe-anemia-due-to-pharyngeal-leech-infestation-a%C3%A2-case-report-from-ethiopia
#1
Nebiyu Shitaye, Segenet Shibabaw
BACKGROUND: Leeches are rare blood-sucking endoparasites. Swimming in streams and ponds as well as drinking contaminated water are the major ways to acquire leeches. CASE PRESENTATION: A 6 year old boy who came with a history of hematemesis, frequent spitting of blood stained saliva, fatigue and anorexia to a rural hospital in Ethiopia. This was a rare case of severe anemia caused by a single leech infestation of laryngopharynx that required blood transfusion. CONCLUSION: Leech infestation should be considered as a source of unexplained hematemesis, spitting of blood and severe anemia in rural areas...
October 12, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28911818/anti-fatigue-activity-of-a-lachnum-polysaccharide-and-its-carboxymethylated-derivative-in-mice
#2
Maheen Mahwish Surhio, Yufen Wang, Shi Fang, Jinglei Li, Ming Ye
The present study was designed to evaluate the anti-fatigue activity of an exopolysaccharide LEP-1b and its carboxymethylated derivative CLEP-1b from a Lachnum sp. Carboxymethylation was confirmed through FT-IR and (13)C NMR spectroscopies, which showed that the (-CH2COOH) group was attached to an oxygen (O) atom of the hydroxyl group on (C-3) of LEP-1b. Each treatment group LEP-1b and CLEP-1b at doses (50, 100, 200mg/kg, respectively) ameliorated physical fatigue and extended exhaustive swimming time in mice...
July 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28911611/antifatigue-and-increasing-exercise-performance-of-actinidia-arguta-crude-alkaloids-in-mice
#3
Yangyang Liu, Changjiang Liu
Actinidia arguta (Siebold et Zucc.) Planch. ex. Miq. is one of the most recently domesticated fruit species with increasing commercial production worldwide. It is a well-known traditional Chinese medicine and is used to reduce blood glucose and treat atopic dermatitis. In addition, it possesses antioxidant, anticancer, and antiallergic properties. In this study, we investigated the physical antifatigue and exercise performance effects of A. arguta crude alkaloids (AACA) extracted with 70% ethanol. Four groups of male Kunming mice (n = 16) were orally administered AACA at doses of 0 mg/kg/d (vehicle), 50 mg/kg/d (AACA-50), 100 mg/kg/d (AACA-100), or 200 mg/kg/d (AACA-200) for 28 days...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28890521/effect-of-burdock-extract-on-physical-performance-and-physiological-fatigue-in-mice
#4
Wen-Chyuan Chen, Yi-Ju Hsu, Mon-Chien Lee, Hua Shuai Li, Chun-Sheng Ho, Chi-Chang Huang, Fu-An Chen
Burdock (BD) is a common vegetable with many pharmacological properties. However, few studies have examined the effect of BD on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of BD on fatigue and ergogenic functions following physical challenge in mice. METHODS: Male ICR mice were divided into four groups to receive either vehicle, or BD at 348.5, 697 or 1,742.5 mg/kg/day, by daily oral gavage for 4 weeks. Exercise performance and fatigue were evaluated from forelimb grip strength, exhaustive swimming time, and post-exercise levels of physical fatigue-related biomarkers serum lactate, ammonia, glucose, and creatine kinase (CK)...
September 11, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28868653/metabonomic-analysis-of-serum-reveals-antifatigue-effects-of-yi-guan-jian-on-fatigue-mice-using-gas-chromatography-coupled-to-mass-spectrometry
#5
Sufang Shui, Xiaorong Cai, Rongqing Huang, Bingkun Xiao, Jianyun Yang
Yi Guan Jian (YGJ), one of the most commonly used traditional Chinese medicines (TCM), has been reported to possess significant antifatigue effects in the eastern. However, the mechanisms underlying its antifatigue effects remain largely unresolved. In this study, a metabonomics approach, involving gas chromatography coupled to mass spectrometry (GC/MS) and a multivariate statistical technique, was developed to estimate the extent to which YGJ alleviated the exhausting swimming induced fatigue of mice. High dose treatment with YGJ significantly extended the swimming time of fatigued mice...
September 3, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28844812/antidepressant-like-effects-of-3-carboxamido-seco-nalmefene-3cs-nalmefene-a-novel-opioid-receptor-modulator-in-a-rat-ifn-%C3%AE-induced-depression-model
#6
Charlotte K Callaghan, Jennifer Rouine, Reginald L Dean, Brian I Knapp, Jean M Bidlack, Daniel R Deaver, Shane M O'Mara
Patients receiving the cytokine immunotherapy, interferon-alpha (IFN-α) frequently present with neuropsychiatric consequences and cognitive impairments. Patients (25-80%) report symptoms of depression, including, anhedonia, irritability, fatigue and impaired motivation. Our lab has previously demonstrated treatment (170,000IU/kg sc, 3 times per week for 4weeks) of the pro-inflammatory cytokine, IFN-α, induced a depressive phenotype in rats in the forced swim test (FST). Here, we examine the biological mechanisms underlying behavioral changes induced by IFN-α, which may be reflective of mechanisms underlying inflammation associated depression...
August 24, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28841149/self-nanoemulsifying-drug-delivery-system-for-resveratrol-enhanced-oral-bioavailability-and-reduced-physical-fatigue-in-rats
#7
Ching-Chi Yen, Chih-Wei Chang, Mei-Chich Hsu, Yu-Tse Wu
Resveratrol (RES), a natural polyphenolic compound, exerts anti-fatigue activity, but its administration is complicated by its low water solubility. To improve RES bioavailability, this study developed a self-nanoemulsifying drug delivery system (SNEDDS) for RES and evaluated its anti-fatigue activity and rat exercise performance by measuring fatigue-related parameters, namely lactate, ammonia, plasma creatinine phosphokinase, and glucose levels and the swimming time to exhaustion. Through solubility and emulsification testing, the optimized SNEDDS composed of Capryol 90, Cremophor EL, and Tween 20 was developed; the average particle size in this formulation, which had favorable self-emulsification ability, was approximately 41...
August 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28835841/swimming-performance-in-juvenile-shortnose-sturgeon-acipenser-brevirostrum-the-influence-of-time-interval-and-velocity-increments-on-critical-swimming-tests
#8
Adam T Downie, James D Kieffer
The most utilized method to measure swimming performance of fishes has been the critical swimming speed (UCrit) test. In this test, the fish is forced to swim against an incrementally increasing flow of water until fatigue. Before the water velocity is increased, the fish swims at the water velocity for a specific, pre-arranged time interval. The magnitude of the velocity increments and the time interval for each swimming period can vary across studies making the comparison between and within species difficult...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28684277/nlrp3-inflammasome-activation-mediates-fatigue-like-behaviors-in-mice-via-neuroinflammation
#9
Ziteng Zhang, Xiujuan Ma, Zhenna Xia, Jikuai Chen, Yangang Liu, Yongchun Chen, Jiangbo Zhu, Jinfeng Li, Huaiyu Yu, Ying Zong, Guocai Lu
Numerous experimental and clinical studies have suggested that the interaction between the immune system and the brain plays an important role in the pathophysiology of chronic fatigue syndrome (CFS). The NLRP3 inflammasome is an important part of the innate immune system. This complex regulates proinflammatory cytokine interleukin-1β (IL-1β) maturation, which triggers different kinds of immune-inflammatory reactions. We employed repeated forced swims to establish a model of CFS in mice. NLRP3 knockout (KO) mice were also used to explore NLRP3 inflammasome activation in the mechanisms of CFS, using the same treatment...
July 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28675237/ursolic-acid-induces-mitochondrial-biogenesis-through-the-activation-of-ampk-and-pgc-1-in-c2c12-myotubes-a-possible-mechanism-underlying-its-beneficial-effect-on-exercise-endurance
#10
Jihang Chen, Hoi Shan Wong, Pou Kuan Leong, Hoi Yan Leung, Wing Man Chan, Kam Ming Ko
Mitochondrial biogenesis, which involves an increase in mitochondrial number and the overall capacity of oxidative phosphorylation, is a critical determinant of skeletal muscle function. Recent findings have shown that some natural products can enhance mitochondrial adaptation to aerobic exercise, which in turn improves exercise performance, presumably by delaying muscle fatigue. Ursolic acid (UA), a natural triterpene, is commonly found in various vegetables and fruits. In the current study, UA was shown to increase mitochondrial mass and ATP generation capacity, with a concomitant production of a low level of mitochondrial reactive oxygen species (ROS) in C2C12 myotubes...
July 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28659748/anti-fatigue-effects-of-dietary-nucleotides-in-mice
#11
Meihong Xu, Rui Liang, Yong Li, Junbo Wang
As the building blocks of nucleic acids, nucleotides are conditionally essential nutrients that exhibit multifaceted activities. The present study aimed to evaluate the anti-fatigue effects of dietary nucleotides (NTs) on mice and explore the possible underlying mechanism. Mice were randomly divided into four experimental sets to detect different indicators. Each set of mice was then divided into four groups: (i) one control group and (ii) three NTs groups, which were fed diets supplemented with NTs at concentrations of 0%, 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28659745/protective-effects-of-tea-polyphenols-on-exhaustive-exercise-induced-fatigue-inflammation-and-tissue-damage
#12
Lixia Liu, Xiuqin Wu, Bingchen Zhang, Wei Yang, Daliang Li, Yanqiu Dong, Yujiao Yin, Qi Chen
Background: The beneficial properties of tea polyphenols have been extensively studied; however, less attention has been paid to their effects, especially anti-inflammatory effect during exhaustive exercise. Objective: The present study assessed the potential protective effects of tea polyphenols against the fatigue, inflammation and tissue injury caused by an exhaustive exercise bout in rats. Design: Twenty-four healthy male rats were divided into three groups. Group C was a sedentary control group, Groups E+TP and Group E performed a single exhaustive swimming test; all groups had normal diets, but Group E+TP was supplemented with tea polyphenols...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28588747/antifatigue-effect-of-luteolin-6-c-neohesperidoside-on-oxidative-stress-injury-induced-by-forced-swimming-of-rats-through-modulation-of-nrf2-are-signaling-pathways
#13
Fang-Fang Duan, Ying Guo, Jing-Wan Li, Ke Yuan
Luteolin-6-C-neohesperidoside (LN) is a flavonoid isolated from moso bamboo leaf. This study was performed to evaluate the antifatigue effect of LN on a rat model undergoing the weight-loaded forced swimming test (FST). Briefly, male Sprague-Dawley rats (20-22 weeks old) were forced to undertake exhaustive swimming every other day for 3 weeks. Each swimming session was followed by the administration of distilled water, LN (25-75 mg/kg), or ascorbic acid (100 mg/kg) 1 h later. Oral administration of LN significantly improved exercise endurance; normalized alterations in energy metabolic markers; and decreased serum lactic acid, lactate dehydrogenase, and blood urea nitrogen levels of rats that underwent FST...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28588427/evaluation-of-anti-fatigue-property-of-the-extruded-product-of-cereal-grains-mixed-with-cordyceps-militaris-on-mice
#14
Lei Zhong, Liyan Zhao, Fangmei Yang, Wenjian Yang, Yong Sun, Qiuhui Hu
BACKGROUND: Fatigue is a biological phenomenon that involves a feeling of extreme physical or mental tiredness that could potentially cause some severe chronic diseases. Recently, diet therapy has provided a new alternative to alleviate physical fatigue. In our previous study, addition of Cordyceps militaris (C. militaris) into an extruded product was shown to provide high nutrition and unique flavors; however, little is known whether this product has some scientific evidence regarding anti-fatigue property...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28578257/melatonin-supplementation-plus-exercise-behavior-ameliorate-insulin-resistance-hypertension-and-fatigue-in-a-rat-model-of-type-2-diabetes-mellitus
#15
Md Mahbubur Rahman, Han-Sol Kwon, Myung-Jin Kim, Hyeon-Kyu Go, Min-Ho Oak, Do-Hyung Kim
INTRODUCTION: The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Rats were divided into 5 groups namely normal control (NC), T2DM control group (DC), diabetes plus exercise (DE), diabetes plus oral melatonin supplement (DM) and diabetes plus melatonin and exercise (DME) groups. Melatonin was administered orally 5mg/kg twice daily and 40min swimming/day 5days/week were regimented after diabetes induction...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28539729/anti-fatigue-effect-of-green-tea-polyphenols-epigallocatechin-3-gallate-egcg
#16
Yu-Song Teng, Di Wu
BACKGROUND: (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant of the green tea polyphenols that exhibit a variety of bioactivities. The objective of this study was to evaluate the anti-fatigue effect of EGCG by forced swimming exercise. MATERIALS AND METHODS: The mice were divided into one control group and three EGCG-treated groups. The control group was administered with distilled water and EGCG-treated groups were administered with different dose of EGCG (50, 100, and 200 mg/kg) by oral gavage for 28 days...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539713/content-determination-of-phenylpropanoids-and-enhancing-exercise-ability-of-effective-fractions-in-pedicularis-densispica
#17
Hongbiao Chu, Zhihua Zhang, Dong Chen, Xi Wang, Qilong Tu
BACKGROUND: Most researches were focused on chemical constituents and bioactivities of Pedicularis. However, there were a few reports on simultaneous determination of the series phenylpropanoids compounds in Pedicularis by High Performance Liquid Chromatography (HPLC). OBJECTIVE: To establish an HPLC method for simultaneous determination of salidroside, verbascoside, iso-verbascoside, leucoseptoside A, jionoside D and martynoside in Pedicularis densispica (PD), and to assess the enhancing exercise ability of effective fractions of phenylpropanoids (EFP)...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28474195/effects-of-temperature-and-fatigue-on-the-metabolism-and-swimming-capacity-of-juvenile-chinese-sturgeon-acipenser-sinensis
#18
Xi Yuan, Yi-Hong Zhou, Ying-Ping Huang, Wen-Tao Guo, David Johnson, Qing Jiang, Jin-Jie Jing, Zhi-Ying Tu
Chinese sturgeon (Acipenser sinensis) is a critically endangered species. A flume-type respirometer, with video, was used to conduct two consecutive stepped velocity tests at 10, 15, 20, and 25 °C. Extent of recovery was measured after the 60-min recovery period between trials, and the recovery ratio for critical swimming speed (U crit) averaged 91.88% across temperatures. Temperature (T) effects were determined by comparing U crit, oxygen consumption rate (MO 2), and tail beat frequency (TBF) for each temperature...
May 4, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28470361/use-of-biotechnology-devices-to-analyse-fatigue-process-in-swimming-training
#19
V J Clemente-Suárez, J J Arroyo-Toledo
The aim of the present research was to analyze the acute psycho-physiological response during a high intensity interval training (HIIT) session of trained swimmers. We analyzed blood lactate concentration, heart rate, heart rate variability (HRV), arms isometric strength, rating of perceived exertion (RPE) and cortical arousal before and after a HIIT session in 14 trained swimmers (16.2 ± 2.6 years 169.1 ± 10.2 cm 61.3 ± 9.9 kg). HIIT session consisted in: 4 × 10 m tethered swimming resting 90 s between sets, 3 min rest, 16 × 25 m maximum speed swimming resting 30 s between sets...
June 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28458274/supplementation-with-hualian-no-4-wild-bitter-gourd-momordica-charantia-linn-var-abbreviata-ser-extract-increases-anti-fatigue-activities-and-enhances-exercise-performance-in-mice
#20
Chien-Yu Hsiao, Yi-Ming Chen, Yi-Ju Hsu, Chi-Chang Huang, Hsin-Ching Sung, Sheng-Shih Chen
Hualian No. 4 wild bitter gourd (WBG) is a specific vegetable cultivated by the Hualien District Agricultural Research and Extension Station in Taiwan. WBG is commonly consumed as a vegetable and used as a popular folk medicine. However, few studies have demonstrated the effects of WBG supplementation on exercise performance, physical fatigue and the biochemical profile. The purpose of this study was to evaluate the potential beneficial effects of WBG extract on fatigue and ergogenic functions following physiological challenge...
June 29, 2017: Journal of Veterinary Medical Science
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