keyword
https://read.qxmd.com/read/38396292/o-glcnacylation-of-e3-ubiquitin-ligase-skp2-promotes-hepatocellular-carcinoma-proliferation
#21
JOURNAL ARTICLE
Zhongqi Feng, Jiaxin Yin, Zhirong Zhang, Zhen Chen, Luyi Huang, Ni Tang, Kai Wang
O-linked-β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) and ubiquitination are critical posttranslational modifications that regulate tumor development and progression. The continuous progression of the cell cycle is the fundamental cause of tumor proliferation. S-phase kinase-associated protein 2 (SKP2), an important E3 ubiquitin ligase, assumes a pivotal function in the regulation of the cell cycle. However, it is still unclear whether SKP2 is an effector of O-GlcNAcylation that affects tumor progression...
February 23, 2024: Oncogene
https://read.qxmd.com/read/38395519/inhibition-of-amino-acid-transporter-lat1-in-cancer-cells-suppresses-g0-g1-s-transition-by-downregulating-cyclin-d1-via-p38%C3%A2-mapk-activation
#22
JOURNAL ARTICLE
Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai
L-type amino acid transporter 1 (LAT1, SLC7A5) is upregulated in various cancers and associated with disease progression. Nanvuranlat (Nanv; JPH203, KYT-0353), a selective LAT1 inhibitor, suppresses the uptake of large neutral amino acids required for rapid growth and proliferation of cancer cells. Previous studies have suggested that the inhibition of LAT1 by Nanv induces the cell cycle arrest at G0/G1 phase, although the underlying mechanisms remain unclear. Using pancreatic cancer cells arrested at the restriction check point (R) by serum deprivation, we found that the Nanv drastically suppresses the G0/G1-S transition after release...
March 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38395514/blockade-of-vasoactive-intestinal-peptide-receptor-2-vipr2-signaling-suppresses-cyclin-d1-dependent-cell-cycle-progression-in-mcf-7%C3%A2-cells
#23
JOURNAL ARTICLE
Satoshi Asano, Ami Ono, Kaede Baba, Teru Uehara, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Souichi Yanamoto, Kotaro Tanimoto, Hitoshi Hashimoto, Yukio Ago
Vasoactive intestinal peptide (VIP) receptor 2 (VIPR2) is a G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling molecules, such as protein kinase A (PKA), phosphatidylinositol 3-kinase (PI3K), and phospholipase C. In this study, we examined the role of VIPR2 in cell cycle progression. KS-133, a newly developed VIPR2-selective antagonist peptide, attenuated VIP-induced cell proliferation in MCF-7 cells. The percentage of cells in the S-M phase was decreased in MCF-7 cells treated with KS-133...
March 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38370338/microrna-329-3p-inhibits-the-wnt-%C3%AE-catenin-pathway-and-proliferation-of-osteosarcoma-cells-by-targeting-transcription-factor-7-like-1
#24
JOURNAL ARTICLE
Hui Sun, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Yuta Kubota, Hiroshi Tsumura, Kazuhiro Tanaka
An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches...
2024: Oncology Research
https://read.qxmd.com/read/38353359/hnrnpc-promotes-estrogen-receptor-positive-breast-cancer-cell-cycle-by-stabilizing-wdr77-mrna-in-an-m6a-dependent-manner
#25
JOURNAL ARTICLE
Wenjie Xu, Ziwei Huang, Yunxiao Xiao, Wenhui Li, Ming Xu, Qiuyang Zhao, Pengfei Yi
Breast cancer has become the most commonly diagnosed cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a reader of N6-methyladenosine (m6A), has been observed to be upregulated in various types of cancer. Nevertheless, the role of HNRNPC in breast cancer and whether it is regulated by m6A modification deserve further investigation. The expression of HNRNPC in breast cancer was examined by quantitative real-time polymerase chain reaction and western blot analysis. RNA immunoprecipitation was performed to validate the binding relationships between HNRNPC and WD repeat domain 77 (WDR77)...
February 14, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38352431/nelf-coordinates-pol-ii-transcription-termination-and-dna-replication-initiation
#26
Chihiro Nakayama, Yasukazu Daigaku, Yuki Aoi, Qi Fang, Hiroshi Kimura, Ali Shilatifard, Michael Tellier, Takayuki Nojima
UNLABELLED: Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is altered in cancer to favour cell growth. Here, we find that gene expression of NELFCD , a known negative elongation factor, is up-regulated in colorectal tumours. To dissect the direct role of NELF-C on Pol II transcription in such cancer, we employed an auxin-dependent protein degradation system for NELF-C in combination with nascent transcript sequencing technologies...
February 1, 2024: bioRxiv
https://read.qxmd.com/read/38349334/periodic-changes-of-cyclin-d1-mrna-stability-are-regulated-by-pc4-modifications-in-the-cell-cycle
#27
JOURNAL ARTICLE
Qimei Pan, Peng Luo, Kaishun Hu, Yuntan Qiu, Gaoyu Liu, Shijie Dai, Bokang Cui, Dong Yin, Chunmeng Shi
The cell cycle is a highly regulated process in which proteins involved in cell cycle progression exhibit periodic expression patterns, controlled by specific mechanisms such as transcription, translation, and degradation. However, the precise mechanisms underlying the oscillations of mRNA levels in cell cycle regulators are not fully understood. In this study, we observed that the stability of cyclin D1 (CCND1) mRNA fluctuates during the cell cycle, with increased stability during interphase and decreased stability during the M phase...
March 4, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38347378/mcm6-inhibits-decidualization-via-cross-talking-with-erk-pathway-in-human-endometrial-stromal-cells
#28
JOURNAL ARTICLE
Yaling Jiang, Yuan Xue, Xinhua Yuan, Shengqin Ye, Mingxing Liu, Yu Shi, Hua Zhou
Decidualization plays an important role in the implantation of the embryo, but the molecular action implicated in this process is not completely known. Herein, we found that, compared with the proliferative endometrial tissues, the expression of minichromosome maintenance complex component 6 (MCM6) was markedly decreased in the secretory endometrial tissues. To verify the function of MCM6 in decidualization, in vitro decidualization model was constructed by treating human endometrial stromal cells (HESCs) with estrogen (E2) and progesterone (P4)...
February 12, 2024: Reproductive Sciences
https://read.qxmd.com/read/38345752/crp-inhibits-the-osteoblastic-differentiation-of-opcs-via-the-up-regulation-of-primary-cilia-and-repression-of-the-hedgehog-signaling-pathway
#29
JOURNAL ARTICLE
Jie Xu, Xiangmei Wu, Huifang Zhu, Yinghua Zhu, Kailong Du, Xiaoyan Deng, Changdong Wang
Inflammation disrupts bone metabolism and leads to bone damage. C-reactive protein (CRP) is a typical inflammation marker. Although CRP measurement has been conducted for many decades, how osteoblastic differentiation influences molecular mechanisms remains largely unknown. The present study attempted to investigate the effects of CRP on primary cultured osteoblast precursor cells (OPCs) while elucidating the underlying molecular mechanisms. OPCs were isolated from suckling Sprague-Dawleyrats. Fewer OPCs were observed after recombinant C-reactive protein treatment...
February 12, 2024: Medical Oncology
https://read.qxmd.com/read/38314926/development-and-therapeutic-potential-of-gspt1-molecular-glue-degraders-a-medicinal-chemistry-perspective
#30
REVIEW
Xiujin Chang, Fangui Qu, Chunxiao Li, Jingtian Zhang, Yanqing Zhang, Yuanyuan Xie, Zhongpeng Fan, Jinlei Bian, Jubo Wang, Zhiyu Li, Xi Xu
Unprecedented therapeutic targeting of previously undruggable proteins has now been achieved by molecular-glue-mediated proximity-induced degradation. As a small GTPase, G1 to S phase transition 1 (GSPT1) interacts with eRF1, the translation termination factor, to facilitate the process of translation termination. Studied demonstrated that GSPT1 plays a vital role in the acute myeloid leukemia (AML) and MYC-driven lung cancer. Thus, molecular glue (MG) degraders targeting GSPT1 is a novel and promising approach for treating AML and MYC-driven cancers...
February 5, 2024: Medicinal Research Reviews
https://read.qxmd.com/read/38314676/effect-of-cdk4-6-inhibitors-on-tumor-immune-microenvironment
#31
REVIEW
Jie Liu, Min Cheng, Jiamei Xu, Yue Liang, Beibei Yin, Jing Liang
Cancer is an abnormal proliferation of cells that is stimulated by cyclin-dependent kinases (CDKs) and defective cell cycle regulation. The essential agent that drive the cell cycle, CDK4/6, would be activated by proliferative signals. Activated CDK4/6 results in the phosphorylation of the neuroblastoma protein (RB) and the release of the transcription factor E2F, which promotes the cell cycle progression. CDK4/6 inhibitor (CDK4/6i) has been currently a research focus, which inhibits the CDK4/6-RB-E2F axis, thereby reducing the cell cycle transition from G1 to S phase and mediating the cell cycle arrest...
February 5, 2024: Immunological Investigations
https://read.qxmd.com/read/38307244/cell-cycle-and-mitosis-progression-during-zika-virus-infection-the-viral-non-structural-protein-ns5-as-a-master-regulator-of-the-apc-cyclosome
#32
JOURNAL ARTICLE
Grégorie Lebeau, Mathilde Hoareau, Sébastien Rivière, Daed El Safadi, Christine Robert Da Silva, Pascale Krejbich-Trotot, Wildriss Viranaicken
Alterations in cell cycle regulation contribute to Zika virus (ZIKV)-associated pathogenesis and may have implications for the development of therapeutic avenues. As a matter of fact, ZIKV alters cell cycle progression at multiple stages, including G1, S, G2, and M phases. During a cell cycle, the progression of mitosis is particularly controlled to avoid any abnormalities in cell division. In this regard, the critical metaphase-anaphase transition is triggered by the activation of anaphase-promoting complex/cyclosome (APC/C) by its E3 ubiquitin ligase subunit Cdc20...
February 1, 2024: Biochimie
https://read.qxmd.com/read/38296052/cdkn2a-p16-deletion-and-activated-kras-g12d-drive-barrett-s-like-gland-hyperplasia-metaplasia-and-synergize-in-the-development-of-dysplasia-pre-cancer-lesions
#33
JOURNAL ARTICLE
Jing Sun, Jorge L Sepulveda, Elena V Komissarova, Caitlin Hills, Tyler D Seckar, Narine M LeFevre, Hayk Simonyan, Colin Young, Gloria Su, Armando Del Portillo, Timothy C Wang, Antonia R Sepulveda
BACKGROUND & AIMS: Barrett's esophagus (BE) is the precursor of esophageal dysplasia and adenocarcinoma (EAC). CDKN2A-p16 deletions were reported in 34-74% of BE patients who progressed to dysplasia and EAC, suggesting that p16 loss may drive neoplastic progression. KRAS activation frequently occurs in EAC and pre-cancer lesions. LGR5+ stem cells in the squamocolumnar-junction (SCJ) of mouse stomach, contribute as BE progenitors. We aimed to determine the functional effects of p16 loss and KRAS activation in Barrett's-like metaplasia and dysplasia development...
January 29, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38289583/lnc-rna-loc102163816-promotes-proliferation-of-porcine-follicular-granulosa-cells-via-mir-455-3p-ptk2b-pi3%C3%A2-k-akt-pathway
#34
JOURNAL ARTICLE
Caomeihui Shen, Tong Chen, Guitian He, Kening Liu, Maosheng Cao, Chenfeng Yuan, Boqi Zhang, Xue Chen, Lu Chen, Yuxin Luo, Yueying Wang, Xu Zhou, Chunjin Li
The proliferation and differentiation of granulosa cells (GCs) is a crucial process in follicular development. However, the molecular regulatory mechanism of follicular proliferation and differentiation of GCs needs further research. Studies have reported that follicular fluid exosomes are involved in regulation of proliferation of GCs, but the specific mechanism is unclear. This study demonstrated that LOC102163816 is upregulated in porcine GCs treated with follicular fluid exosomes. Further study defined LOC102163816 to be a novel long non-coding RNA that is highly homologous to human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and enriched in porcine follicular fluid exosomes...
January 30, 2024: Endocrinology
https://read.qxmd.com/read/38287498/genome-wide-loss-of-function-genetic-screen-identifies-insig2-as-the-vulnerability-of-hepatitis-b-virus-integrated-hepatoma-cells
#35
JOURNAL ARTICLE
Makoto Fukuoka, Takahiro Kodama, Kazuhiro Murai, Hayato Hikita, Emi Sometani, Jihyun Sung, Akiyoshi Shimoda, Satoshi Shigeno, Daisuke Motooka, Akira Nishio, Kunimaro Furuta, Tomohide Tatsumi, Kosuke Yusa, Tetsuo Takehara
There are approximately 250 million people chronically infected with hepatitis B virus (HBV) worldwide. Although HBV is often integrated into the host genome and promotes hepatocarcinogenesis, vulnerability of HBV integration in liver cancer cells has not been clarified. The aim of our study is to identify vulnerability factors for HBV-associated hepatocarcinoma. Loss-of-function screening was undertaken in HepG2 and HBV-integrated HepG2.2.15 cells expressing SpCas9 using a pooled genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) library...
January 29, 2024: Cancer Science
https://read.qxmd.com/read/38263533/knockdown-of-kmt2d-leads-to-growth-impairment-by-activating-the-akt-%C3%AE-catenin-signaling-pathway
#36
JOURNAL ARTICLE
Huakun Shangguan, Xiaozhen Huang, Jinduan Lin, Ruimin Chen
The KMT2D variant-caused Kabuki syndrome (KS) is characterized by short stature as a prominent clinical characteristic. The initiation and progression of body growth are fundamentally influenced by chondrocyte proliferation. Uncertainty persists regarding the possibility that KMT2D deficiency affects growth by impairing chondrocyte proliferation. In this study, we used the CRISPR/Cas13d technique to knockdown kmt2d in zebrafish embryos and lentivirus to create a stable Kmt2d gene knockdown cell line in chondrocytes (ATDC5 cells)...
January 23, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38262041/mrci-study-of-the-electronic-structure-and-transition-properties-of-a-tin-dimer
#37
JOURNAL ARTICLE
Lidan Xiao, Jianlei Xue, Boris F Minaev, Bing Yan
The ground and excited states of Sn2 are calculated using the multireference configuration interaction method combined with Davidson correction (MRCI+Q). The influence of the spin-orbit coupling (SOC) effect on the electronic structure is also considered by the state interaction method of Breit-Pauli Hamiltonian. In the calculations, the potential energy curves and spectroscopic constants of 23 Λ-S states and 31 Ω states of Sn2 are obtained. The prominent spectral features in the visible region, new constants, and potential energy curves are discussed...
January 23, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38260464/mitochondrial-choline-import-regulates-purine-nucleotide-pools-via-slc25a48
#38
Anthony R P Verkerke, Xu Shi, Ichitaro Abe, Robert E Gerszten, Shingo Kajimura
UNLABELLED: Choline is an essential nutrient for cellular metabolism, including the biosynthesis of phospholipids, neurotransmitters, and one-carbon metabolism. A critical step of choline catabolism is the mitochondrial import and synthesis of chorine-derived methyl donors, such as betaine. However, the underlying mechanisms and the biological significance of mitochondrial choline catabolism remain insufficiently understood. Here, we report that a mitochondrial inner-membrane protein SLC25A48 controls mitochondrial choline transport and catabolism in vivo ...
January 1, 2024: bioRxiv
https://read.qxmd.com/read/38260436/d-type-cyclins-regulate-dna-mismatch-repair-in-the-g1-and-s-phases-of-the-cell-cycle-maintaining-genome-stability
#39
Gergely Rona, Bearach Miwatani-Minter, Qingyue Zhang, Hailey V Goldberg, Marc A Kerzhnerman, Jesse B Howard, Daniele Simoneschi, Ethan Lane, John W Hobbs, Elizabeth Sassani, Andrew A Wang, Sarah Keegan, Daniel J Laverty, Cortt G Piett, Lorinc S Pongor, Miranda Li Xu, Joshua Andrade, Anish Thomas, Piotr Sicinski, Manor Askenazi, Beatrix Ueberheide, David Fenyö, Zachary D Nagel, Michele Pagano
UNLABELLED: The large majority of oxidative DNA lesions occurring in the G1 phase of the cell cycle are repaired by base excision repair (BER) rather than mismatch repair (MMR) to avoid long resections that can lead to genomic instability and cell death. However, the molecular mechanisms dictating pathway choice between MMR and BER have remained unknown. Here, we show that, during G1, D-type cyclins are recruited to sites of oxidative DNA damage in a PCNA- and p21-dependent manner. D-type cyclins shield p21 from its two ubiquitin ligases CRL1 SKP2 and CRL4 CDT2 in a CDK4/6-independent manner...
January 13, 2024: bioRxiv
https://read.qxmd.com/read/38243003/tfap2c-activates-cst1-transcription-to-facilitate-breast-cancer-progression-and-suppress-ferroptosis
#40
JOURNAL ARTICLE
Lin Yuan, Di Zhou, Weiwen Li, Jianhua Guan, Junda Li, Bo Xu
Cystatin SN (CST1) appears to have pro-tumor effects in breast cancer (BC) and is involved in ferroptosis; however, there is no report on the regulation of ferroptosis by CST1 for BC development. The purpose of this study is to investigate the functions and mechanisms operated by CST1 in BC development and ferroptosis. Transcription Factor Activator Protein 2γ (TFAP2C) and CST1 levels in BC tissues and estrogen receptor (ER)+ cells were quantified by RT-qPCR and western blotting. After knocking down TFAP2C and CST1 expression in MCF7 and T47D cells, the proliferation, colony formation ability, apoptosis, and cell cycle were assessed...
January 19, 2024: Biochemical Genetics
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