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https://www.readbyqxmd.com/read/28076737/absolute-risk-of-cardiovascular-disease-events-and-blood-pressure-and-lipid-lowering-therapy-in-australia
#1
Emily Banks, Rosemary J Korda, Bill Stavreski
No abstract text is available yet for this article.
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28073192/the-use-of-autologous-platelet-rich-plasma-gel-in-bulbar-and-penile-buccal-mucosa-urethroplasty-preliminary-report-of-our-first-series
#2
Marcello Scarcia, Francesco Paolo Maselli, Giuseppe Cardo, Giuseppe Mario Ludovico
OBJECTIVE: The Buccal Mucosa (BM) UrethroPlasty (UP) is one of the preferred treatments for long or compli-cated urethral strictures. We propose the use of autologous Platelet Rich Plasma gel (aPRPg) in order to enhance to vascularization of BM graft and reduce the fibrous spongy. We report the outcome of our ten cases of bulbar and penile UP and the safety of this technique. Materials and metods: Ten patients underwent to BM UP with use of aPRP gel. Median age was 46. Stricture etiology was idiopathic, failed hypospadias and flogistic...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28072844/exploring-the-possibility-of-cryopreservation-of-feline-and-canine-erythrocytes-by-rapid-freezing-with-penetrating-and-non-penetrating-cryoprotectants
#3
Denys Pogozhykh, Yuliya Pakhomova, Olga Pervushina, Nicola Hofmann, Birgit Glasmacher, Gennadiy Zhegunov
Efficient application of veterinary blood transfusion approaches for small companion animals requires readily available supply of the donor material. This can be achieved by developing of effective biobanking technologies allowing long-term storage of donor blood components via cryopreservation. Transfusion of an erythrocyte concentrate allows the successful correction of various hematological pathologies, severe bleeding, and etc. While in the past there were several approaches to cryopreserve red blood cells of dogs, to our knowledge there is virtually no data on cryopreservation of feline erythrocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28057873/attainment-of-guideline-targets-in-eurodopps-haemodialysis-patients-are-differences-related-to-a-country-s-healthcare-expenditure-and-nephrologist-workforce
#4
Sophie Liabeuf, Karlijn J Van Stralen, Fergus Caskey, Francesca Tentori, Ronald L Pisoni, Ayesha Sajjad, Kitty J Jager, Ziad A Massy
BACKGROUND: In the field of chronic kidney disease, global clinical practice guidelines have been developed and implemented with a view to improving patient care and outcomes. The attainment of international and European guideline targets for haemodialysis patients in European countries has not been audited recently. Hence, we sought to establish whether the attainment of the targets set out in guidelines and inappropriate care are similar across European countries and whether inter-country differences are related to disparities in national healthcare expenditures (as a percentage of gross domestic product) and/or the nephrologist workforce per capita...
January 5, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28050376/a-retrospective-analysis-of-apheresis-donor-deferral-and-adverse-reactions-at-a-tertiary-care-centre-in-india
#5
Disha Arora, Ketan Garg, Ankit Kaushik, Richa Sharma, D S Rawat, A K Mandal
INTRODUCTION: With increasing demand of platelet component each day, blood bank plays a pivotal role in ensuring supply of safe blood as and when required. Plateletpheresis procedure is a relatively simple, safe and important adjunct to blood bank inventory. However, recruitment of healthy blood donors is a challenge that the health industry is facing today. AIM: To determine the reasons and rates of apheresis donor deferral along with investigation of adverse reactions encountered during the procedure...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050068/blood-transfusion-practices-among-delivery-cases-a-retrospective-study-of-two-years
#6
S K Kathpalia, Jaya Chawla, A K Harith, Priyanka Gupta, Anupam Anveshi
BACKGROUND: Many women die while going through childbirth; hemorrhage being common cause for maternal mortality. Many maternal deaths can be saved by building up hemoglobin antenatally and timely blood transfusion. The transfusion may result in many complications hence the blood transfusion practices should be streamlined and adhered to and reviewed periodically. This retrospective study was undertaken at one of the tertiary care hospital to find out the blood demand and utilization practices among the delivery cases and suggest measures if any to improve the existing practices...
December 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28041964/association-between-dna-methyltransferase-gene-polymorphism-and-parkinson-s-disease
#7
Julio Carlos Pezzi, Cintia Monique Boschmann Ens de Bem, Tatiane Jacobsen da Rocha, Artur F Schumacher-Schuh, Marcia Lorena Fagundes Chaves, Carlos Roberto Rieder, Mara H Hutz, Marilu Fiegenbaum, Ana Luiza Camozzato
Parkinson's disease (PD) is a common and complex neurodegenerative disorder, the second most prevalent, only behind Alzheimer's disease. Recent studies suggest that environmental factors may contribute for neurodegeneration through induction of epigenetic modifications, such as DNA methylation, that is carried out by enzymes, such as DNMT1 and DNMT3B. This present study targeted to investigate the association among DNMT1 and DNMT3B polymorphisms with PD. Five hundred and twenty-two participants (214 PD patients following UK Brain Bank criteria and 308 healthy individuals) were evaluated...
December 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28035915/modulators-of-igg-penetration-through-the-blood-brain-barrier-implications-for-alzheimer-s-disease-immunotherapy
#8
John M Finke Null, William A Banks Null
No abstract text is available yet for this article.
December 23, 2016: Human Antibodies
https://www.readbyqxmd.com/read/28031553/genetic-origin-of-beh%C3%A3-et-s-disease-population-in-denizli-turkey-population-genetics-data-analysis-historical-demography-and-geographical-perspectives-based-on-%C3%AE-globin-gene-cluster-haplotype-variation
#9
O Ozturk, S Arikan, A Bahadir, A Atalay, E O Atalay
In our study, we aimed to investigate the possible genetic drift, relationships, expansion and historical origin based on haplotype frequencies of the β-globin gene cluster of normal and Behçet's disease (BD) population in Denizli, Turkey. We examined blood DNA samples obtained from our DNA bank. The association of population genetic parameters such as haplotypes, diversity, differentiation, Hardy-Weinberg equilibrium and demographic analysis for two populations was performed by Arlequin ver. 3.5. Our results show that both populations have high similarity in genetic parameters in terms of development and expansion based on haplotype diversity through the history...
December 29, 2016: Genes and Immunity
https://www.readbyqxmd.com/read/28029567/blood-discard-rate-in-a-blood-center-in-curitiba-brazil-ten-years-of-study
#10
Aline G Monich, Tiago W Dantas, Karla B Fávero, Paulo T R Almeida, Eliane C Maluf, Carolina De M Capeletto, Renato M Nisihara
INTRODUCTION: Development of technologies to reduce transfusion risks of infectious diseases is a major characteristic of hemotherapy. Thus, each donation undergoes clinical and serological screening tests to ensure the donated blood do not offer risks to the receiver. OBJECTIVE: Evaluate the prevalence of positive serology in blood donations rejected by Hemobanco (Curitiba - PR) in the period ranging from January 2003 to December 2012. METHODOLOGY: During the period studied, we observed the total number of donations and its division according to gender...
October 25, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28028998/long-term-quality-control-program-plan-for-cord-blood-banks-in-korea-a-pilot-study-for-cryopreservation-stability
#11
Soo Hyun Seo, Sue Shin, Eun Youn Roh, Eun Young Song, Sohee Oh, Byoung Jae Kim, Jong Hyun Yoon
BACKGROUND: Maintaining the quality of cryopreserved cord blood is crucial. In this pilot study, we describe the results of the internal quality control program for a cord blood bank thus far. METHODS: Donated cord blood units unsuitable for transplantation were selected for internal quality control once a month. One unit of cord blood, aliquoted into 21 capillaries, was cryopreserved and thawed annually to analyze the total nucleated cell count, CD34⁺ cell count, cell viability test, and colony-forming units assay...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028997/comparative-analysis-of-clinical-samples-showing-weak-serum-reaction-on-autovue-system-causing-abo-blood-typing-discrepancies
#12
Su Yeon Jo, Ju Mi Lee, Hye Lim Kim, Kyeong Hwa Sin, Hyeon Ji Lee, Chulhun Ludgerus Chang, Hyung Hoi Kim
BACKGROUND: ABO blood typing in pre-transfusion testing is a major component of the high workload in blood banks that therefore requires automation. We often experienced discrepant results from an automated system, especially weak serum reactions. We evaluated the discrepant results by the reference manual method to confirm ABO blood typing. METHODS: In total, 13,113 blood samples were tested with the AutoVue system; all samples were run in parallel with the reference manual method according to the laboratory protocol...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28027853/a-haemovigilance-team-provides-both-significant-financial-and-quality-benefits-in-a-university-hospital
#13
Ine Decadt, Els Costermans, Maai Van de Poel, Katrien Kesteloot, Timothy Devos
BACKGROUND: Haemovigilance is the process of surveillance of blood transfusion procedures including unexpected hazards and reactions during the transfusion pathway in both donors and recipients. The haemovigilance team aims to increase blood transfusion safety and to decrease both morbidity and mortality in donors and recipients. The team collects data about transfusion reactions and incidents, instructs the involved health workers and assures the tracing of blood components. The haemovigilance team at the University Hospitals Leuven has played a pioneering role in the development of haemovigilance in Belgium Although the literature about safety and quality improvements by haemovigilance systems is abundant, there are no published data available measuring their financial impact in a hospital...
December 7, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28027505/impairment-of-dynamic-thiol-disulphide-homeostasis-in-patients-with-idiopathic-parkinson-s-disease-and-its-relationship-with-clinical-stage-of-disease
#14
Gonul Vural, Sadiye Gumusyayla, Hesna Bektas, Orhan Deniz, Murat Alisik, Ozcan Erel
OBJECTIVE: The aim of this study was to investigate dynamic thiol-disulphide homeostasis in patients with idiopathic Parkinson's disease and to determine its relationship with the clinical stage as assessed by the modified Hoehn and Yahr scale. DESIGN AND METHODS: Fifty-two patients with Parkinson's disease (PD), diagnosed according to the United Kingdom Brain Bank Criteria for idiopathic PD, and 41 healthy individuals were included in the study. Clinical staging of patients was performed according to the Hoehn and Yahr scale...
December 23, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28019031/pathogen-inactivation-by-riboflavin-and-ultraviolet-light-illumination-accelerates-the-red-blood-cell-storage-lesion-and-promotes-eryptosis
#15
Syed M Qadri, Deborah Chen, Peter Schubert, Darian L Perruzza, Varsha Bhakta, Dana V Devine, William P Sheffield
BACKGROUND: Pathogen reduction treatment using riboflavin and ultraviolet light illumination (Mirasol) effectively reduces the risk of transfusion-transmitted infections. This treatment is currently licensed for only platelets and plasma products, while its application to whole blood (WB) to generate pathogen-inactivated red blood cells (RBCs) is under development. RBC storage lesion, constituting numerous morphologic and biochemical changes, influences RBC quality and limits shelf life...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28012848/detection-of-sessile-serrated-adenomas-in-proximal-colon-using-wide-field-fluorescence-endoscopy
#16
Bishnu P Joshi, Zhenzhen Dai, Zhenghong Gao, Jeong Hoon Lee, Navin Ghimire, Jing Chen, Anoop Prabhu, Erik J Wamsteker, Richard S Kwon, Grace H Elta, Elena M Stoffel, Asha Pant, Tonya Kaltenbach, Roy M Soetikno, Henry D Appelman, Rork Kuick, D Kim Turgeon, Thomas D Wang
BACKGROUND & AIMS: Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigated whether this feature could be used with imaging methods to detect SSAs in patients. METHODS: We used phage display to identify a peptide that binds specifically to SSAs, using subtractive hybridization with HT29 colorectal cancer cells containing the V600E mutation in BRAF and Hs738...
December 21, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28011392/selective-induction-of-p-glycoprotein-at-the-cns-barriers-during-symptomatic-stage-of-an-als-animal-model
#17
Gary N Y Chan, Rebecca A Evans, David B Banks, Emily V Mesev, David S Miller, Ronald E Cannon
P-glycoprotein (P-gp), Breast cancer resistance protein (BCRP) and Multidrug resistance-associated protein 2 (MRP2) residing at the blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are major obstacles for drug delivery to the Central Nervous System (CNS). Disease-induced changes of these xenobiotic transporters at the CNS barriers have been previously documented. Changes in the functional expression of these transporters at the CNS barriers would limit the clinical efficacy of therapeutic agents targeting the CNS...
December 21, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28009639/increased-expression-of-the-type-i-interferon-receptor-on-cd4-t-lymphocytes-in-hiv-1-infected-individuals
#18
M Scott Killian, Sue H Fujimura, Ramu G Sudhagoni
BACKGROUND: Type I interferons (IFN1; e.g. IFN-α and IFN-β) are potent cytokines that inhibit the replication of human immunodeficiency virus-1 (HIV-1) and other viruses. The antiviral and immunoregulatory activities of IFN1 are mediated through ligand/receptor interactions with the IFN1 receptor complex (IFNAR). Variation in the cell surface density of IFNAR could play a role in HIV-1 pathogenesis. METHODS: In this cross-sectional study of fresh whole blood, we used flow cytometry to evaluate the expression of IFNAR2 on lymphocyte subsets from HIV-1-infected (n=33) and -uninfected (n=22) individuals...
December 22, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28007780/ficin-treated-red-cells-help-identify-clinically-significant-alloantibodies-masked-as-reactions-of-undetermined-specificity-in-gel-microtubes
#19
Ben C Hill, Courtney A Hanna, Jill Adamski, Huy P Pham, Marisa B Marques, Lance A Williams
Non-specific antibodies or antibodies of undetermined significance (AUS) often pose problems for a blood bank technologist and physician. It is well known that antibodies can weaken and evanesce over time, thus eluding detection by routine blood bank techniques. Special enhancement techniques exist (eg, ficin treatment); however, they are often underutilized due to concerns over expense. Ficin is known to enhance reactivity caused by antibodies in the ABO, Rh, Kidd, Lewis, I, and P blood group systems, while destroying reactivity of antibodies in the Duffy, and MNS blood group systems...
December 22, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/28007597/computational-proteome-wide-screening-predicts-neurotoxic-drug-protein-interactome-for-the-investigational-analgesic-bia-10-2474
#20
Steven V Molinski, Vijay M Shahani, Stephen S MacKinnon, Leonard D Morayniss, Marcon Laforet, Geoffrey Woollard, Naheed Kurji, Cecilia G Sanchez, Shoshana J Wodak, Andreas Windemuth
The investigational compound BIA 10-2474, designed as a long-acting and reversible inhibitor of fatty acid amide hydrolase for the treatment of neuropathic pain, led to the death of one participant and hospitalization of five others due to intracranial hemorrhage in a Phase I clinical trial. Putative off-target activities of BIA 10-2474 have been suggested to be major contributing factors to the observed neurotoxicity in humans, motivating our study's proteome-wide screening approach to investigate its polypharmacology...
December 20, 2016: Biochemical and Biophysical Research Communications
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