Kazuya Nagayabu, Shigehisa Fumino, Ai Shimamura, Yuki Sengoku, Mayumi Higashi, Masafumi Iguchi, Shigeyoshi Aoi, Shibata Saya, Maki Hirai, Hiroshi Ogi, Aya Miyagawa-Hayashino, Eiichi Konishi, Kyoko Itoh, Tatsuro Tajiri, Shigeru Ono
INTRODUCTION: Biliary atresia (BA) is a cholestatic hepatopathy caused by fibrosing destruction of intrahepatic and extrahepatic bile ducts, and its etiology has not been clearly revealed. In BA, liver fibrosis progression is often observed even after Kasai portoenterostomy (KPE), and more than half of cases require liver transplantation in their lifetime in Japan. Macrophages play an important role in liver fibrosis progression and are classically divided into proinflammatory (M1) and fibrotic macrophages (M2), whose phenotypic transformation is called "macrophage polarity...
2024: Frontiers in Pediatrics