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https://www.readbyqxmd.com/read/29156808/serum-hepatitis-b-surface-antigen-levels-predict-insignificant-fibrosis-and-non-cirrhosis-in-hepatitis-b-e-antigen-positive-patients-with-normal-or-mildly-elevated-alanine-transaminase-levels
#1
Qiang Li, Weixia Li, Chuan Lu, Yuxian Huang, Liang Chen
BACKGROUND/AIMS: We aimed to evaluate the diagnostic value of serum hepatitis B surface antigen (HBsAg) levels for liver fibrosis in hepatitis B e antigen-positive [HBeAg (+)] chronic hepatitis B (CHB) patients with alanine transaminase (ALT)≤twice upper limit of normal (ULN). METHODS: 505 patients who underwent liver biopsies and HBsAg quantitative detections were included. Liver histology was scored using METAVIR scoring system. The area under the receiver-operator curve (AUROC) was used to determine the diagnostic accuracy...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29114703/validation-of-hepa-index-as-a-non-invasive-biomarkers-panel-for-assessment-of-hepatic-fibrosis-in-egyptians-with-chronic-hepatitis-c
#2
Mohamed Alboraie, Kerstin Schütte, Marwa Khairy, Marwa Elsharkawy, Noha Asem, Fathy Elghamry, Helmy Shalaby, Gamal Esmat, Peter Malfertheiner
To validate the diagnostic performance of Hepa-Index in predicting different stages of hepatic fibrosis in Egyptian patients with chronic hepatitis C (CHC). Methods: Hundred treatment naïve chronic hepatitis C Egyptian patients were prospectively enrolled between June 2014 and January 2015. They were subjected to: platelet count, alpha-2-macroglobulin (α2-MG), total bilirubin, gamma glutamyl transpeptidase (GGT), total cholesterol, liver biopsy and histopathological staging of hepatic fibrosis according to METAVIR scoring system...
November 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29077697/assessment-of-liver-fibrosis-using-real-time-shear-wave-elastography-for-patients-with-hepatitis-b-e-antigen-negative-chronic-hepatitis-b-and-alanine-transaminase-2-times-the-upper-limit-of-normal
#3
Jing-Hua Liu, Yu Zou, Wei Chang, Jun Wu, Yu Zou, Yu-Chen Xie, Yong-Ping Lu, Jia Wei
BACKGROUND: We assessed liver fibrosis using real-time shear-wave elastography (SWE) combined with liver biopsy (LB) for patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) and alanine transaminase < 2 times the upper limit of normal and hepatitis B virus DNA < 2000 IU/ml. METHODS: A total of 107 patients met the inclusion criteria. Real- ime SWE and ultrasoundassisted liver biopsies were consecutively performed. Fibrosis was staged according to the METAVIR scoring system...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29073121/transient-elastography-fibroscan-performs-better-than-non-invasive-markers-in-assessing-liver-fibrosis-and-cirrhosis-in-autoimmune-hepatitis-patients
#4
Liwei Guo, Lei Zheng, Liyang Hu, Huanhuan Zhou, Lifei Yu, Weifeng Liang
BACKGROUND Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease that can lead to severe fibrosis and cirrhosis. Transient elastography (TE, FibroScan) can assess the fibrotic stages of chronic liver diseases by liver stiffness measurement (LSM). Studies on the diagnostic accuracy of FibroScan for the detection of fibrosis in AIH patients are still limited. MATERIAL AND METHODS This study enrolled 108 AIH patients who underwent liver biopsies. Using the METAVIR scoring system as the reference, Spearman's rank correlation was performed to explore the relationship between the markers and stages of fibrosis...
October 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29065124/sustained-virological-response-halts-fibrosis-progression-a-long-term-follow-up-study-of-people-with-chronic-hepatitis-c-infection
#5
Swee Lin G Chen Yi Mei, Alexander J Thompson, Britt Christensen, Georgina Cunningham, Lucy McDonald, Sally Bell, David Iser, Tin Nguyen, Paul V Desmond
BACKGROUND/AIMS: Long-term follow-up studies validating the clinical benefit of sustained virological response (SVR) in people with chronic hepatitis C (CHC) infection are lacking. Our aim was to identify rates and predictors of liver fibrosis progression in a large, well characterized cohort of CHC patients in whom paired liver fibrosis assessments were performed more than 10 years apart. METHODS: CHC patients who had undergone a baseline liver biopsy pre-2004 and a follow up liver fibrosis assessment more than 10 years later (biopsy or liver stiffness measurement (LSM) using transient elastography [FibroScan]) were identified...
2017: PloS One
https://www.readbyqxmd.com/read/29062242/impact-of-hepatitis-c-virus-genotype-4-eradication-following-direct-acting-antivirals-on-liver-stiffness-measurement
#6
Mohammed Tag-Adeen, Ahlam Mohamed Sabra, Yuko Akazawa, Ken Ohnita, Kazuhiko Nakao
BACKGROUND: Liver fibrosis is the most important prognostic factor in chronic hepatitis C virus (HCV) patients, and Egypt shows the highest worldwide HCV prevalence with genotype-4 pre-dominance. The aim of this study was to investigate the degree of liver stiffness measurement (LSM) improvement after successful HCV eradication. PATIENTS AND METHODS: The study included 84 chronic HCV Egyptian patients, and was conducted at Qena University Hospital from November 1, 2015 till October 31, 2016...
2017: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/29057268/latent-class-analysis-of-noninvasive-methods-and-liver-biopsy-in-chronic-hepatitis-c-an-approach-without-a-gold-standard
#7
Flavia F Fernandes, Hugo Perazzo, Luiz E Andrade, Alessandra Dellavance, Carlos Terra, Gustavo Pereira, João L Pereira, Frederico Campos, Maria L Ferraz, Renata M Perez
AIMS: To evaluate the applicability of the Latent Class Analysis (LCA) and accuracy of transient elastography (TE), aspartate-to-platelet-ratio-index (APRI), enhanced liver fibrosis (ELF), and liver biopsy (LB) for liver fibrosis assessment in a model without a gold standard. METHODS: Significant fibrosis was defined as TE ≥ 7.1 kPa, APRI ≥ 1.5, ELF ≥ 9.37, or LB METAVIR F ≥ 2. Cirrhosis was defined as TE ≥ 12.5 kPa, APRI ≥ 2.0, ELF ≥ 10.31, or LB as METAVIR F = 4...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29055926/an-inexpensive-digital-image-analysis-technique-for-liver-fibrosis-quantification-in-chronic-hepatitis-b-patients
#8
Yin Zhou, Guo Qing Ru, Rong Yan, Ming Shan Wang, Mei Juan Chen, Li Li Yu, Hong Wang
BACKGROUND AND AIM: Quantitative digital imaging analysis to evaluate liver fibrosis is accurate, but its clinical use is limited by its high cost and lack of standardization. We aimed to validate an inexpensive digital imaging analysis technique for fibrosis quantification in chronic hepatitis B patients. MATERIAL AND METHODS: In total, 142 chronic hepatitis B patients who underwent liver biopsy and analysis of serum fibrosis markers were included. Images of Sirius red stain sections were captured and processed using Adobe Photoshop CS3 software...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29055924/fibrogenic-angiogenic-linker-for-non-invasive-assessment-of-hepatic-fibrosis-staging-in-chronic-hepatitis-c-among-egyptian-patients
#9
El-Shahat A Toson, Gamal E Shiha, Asmaa E Abdelgaleel
Background and rationale for the study. Liver biopsy is the golden standard for staging liver fibrosis, but it may be accompanied by complications. Because of this complication, the aim of this study is to evaluate a simple noninvasive score to assess hepatic fibrosis in chronic hepatitis C genotype 4 patients which is very may have an important in diagnosis and therapeutic decision. This score [HA vascular (HAV) score] is a combination of direct markers [hyaluronic acid (HA) and vascular endothelial growth factor (VEGF)] and indirect markers [aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR)]...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29030995/magnetic-resonance-elastography-is-as-accurate-as-liver-biopsy-for-liver-fibrosis-staging
#10
Hiroyuki Morisaka, Utaroh Motosugi, Shintaro Ichikawa, Tadao Nakazawa, Tetsuo Kondo, Satoshi Funayama, Masanori Matsuda, Tomoaki Ichikawa, Hiroshi Onishi
BACKGROUND: Liver MR elastography (MRE) is available for the noninvasive assessment of liver fibrosis; however, no previous studies have compared the diagnostic ability of MRE with that of liver biopsy. PURPOSE: To compare the diagnostic accuracy of liver fibrosis staging between MRE-based methods and liver biopsy using the resected liver specimens as the reference standard. STUDY TYPE: A retrospective study at a single institution. POPULATION: In all, 200 patients who underwent preoperative MRE and subsequent surgical liver resection were included in this study...
October 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29026473/hepatitis-c-genotypes-in-libya-correlation-with-patients-characteristics-level-of-viremia-and-degree-of-liver-fibrosis
#11
Abdel-Naser Elzuoki, Islam Elzouki, Sabah Albarassi, Mohamed Gammo, Abdalla Burwaiss
OBJECTIVES: Our study sought to determine the distribution of hepatitis C virus (HCV)-genotypes among patients attending two tertiary care hospitals in Benghazi and Tripoli, Libya, and correlate this with patient's characteristics, viral load, and degree of fibrosis. METHODS: We conducted a retrospective study of 286 HCV-RNA positive Libyan patients referred from different health care facilities in east and west Libya for specific HCV treatment. HCV genotyping was carried out by gene amplification...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29023554/reproducibility-of-shear-wave-elastography-swe-in-patients-with-chronic-liver-disease
#12
Marcello Mancini, Angelo Salomone Megna, Monica Ragucci, Massimo De Luca, Giuseppina Marino Marsilia, Gerardo Nardone, Pietro Coccoli, Anna Prinster, Lorenzo Mannelli, Emilia Vergara, Serena Monti, Raffaele Liuzzi, Mariarosaria Incoronato
The presence of significant fibrosis is an indicator for liver disease staging and prognosis. The aim of the study was to determine reproducibility of real-time shear wave elastography using a hepatic biopsy as the reference standard to identify patients with chronic liver disease. Forty patients with chronic liver disease and 12 normal subjects received shear wave elastography performed by skilled operators. Interoperator reproducibility was studied in 29 patients. Fibrosis was evaluated using the Metavir score...
2017: PloS One
https://www.readbyqxmd.com/read/29018269/adar1-polymorphisms-are-related-to-severity-of-liver-fibrosis-in-hiv-hcv-coinfected-patients
#13
Luz M Medrano, Juan Berenguer, María A Jiménez-Sousa, Teresa Aldámiz-Echevarria, Francisco Tejerina, Cristina Diez, Lorena Vigón, Amanda Fernández-Rodríguez, Salvador Resino
The adenosine deaminase acting on RNA (ADAR1) gene is an interferon-stimulated gene involved in liver injury protection. Our aim was to analyze the association of polymorphisms within this gene with the severity of liver disease in European HIV/HCV-coinfected patients. We performed a cross-sectional study in 220 patients that underwent a liver biopsy. Five SNPs in the ADAR1 gene (rs1127326, rs1127317, rs1127314, rs1127313, rs2229857) were genotyped by GoldenGate assay. The outcome variables were fibrosis stage and necroinflammatory activity grade by METAVIR-score, aspartate aminotransferase to platelet ratio index (APRI), FIB-4 index, and fibrosis progression rate (FPR)...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28990680/baseline-ns5a-resistance-associated-substitutions-may-impair-daa-response-in-real-world-hepatitis-c-patients
#14
Itziar Carrasco, Ana Arias, Laura Benítez-Gutiérrez, Gema Lledó, Silvia Requena, Miriam Cuesta, Valentín Cuervas-Mons, Carmen de Mendoza
BACKGROUND: Oral DAA have demonstrated high efficacy as treatment of hepatitis C. However, the presence of resistance-associated substitutions (RAS) at baseline has occasionally been associated with impaired treatment response. Herein, we examined the impact of baseline RAS at the HCV NS5A gene region on treatment response in a real-life setting. METHODS: All hepatitis C patients treated with DAA including NS5A inhibitors at our institution were retrospectively examined...
October 9, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28969178/association-of-serum-lipids-with-hepatic-steatosis-stage-of-liver-fibrosis-and-viral-load-in-chronic-hepatitis-c
#15
Ivan Valkov, Radina Ivanova, Assen Alexiev, Krasimir Antonov, Lyudmila Mateva
INTRODUCTION: Hepatitis C Virus (HCV) relies on host lipids for its life cycle contributing to lipid abnormalities and hepatic steatosis. Disease progression is influenced by viral factors interacting with host immune and metabolic pathways. The significance of serum lipids for Chronic Hepatitis C (CHC) assessment is not clearly established yet. AIM: Our aim was to investigate serum lipids' association with stage of liver fibrosis, steatosis and genotypes in patients with CHC...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969177/visceral-adiposity-index-and-the-degree-of-hepatic-fibrosis-and-inflammation-in-egyptian-patients-with-chronic-hepatitis-c
#16
Zainab Ahmed Ali-Eldin, Fatma Ahmed Ali-Eldin, Inas Elkhedr Mohamed
INTRODUCTION: Many clinical studies suggest a direct association between hepatic fat content and visceral adiposity and the progression of fibrosis. AIM: This work aims to clarify the relation between the Visceral Adiposity Index (VAI) and severity of necroinflammatory activity and liver fibrosis in Egyptian patients with chronic Hepatitis C Virus (HCV) infection. MATERIALS AND METHODS: A cross-sectional study, over a period of six months, was performed on 50 chronic HCV patients subjected to routine laboratory investigations, abdominal ultrasonography, measurement of Waist Circumference (WC), calculation of Body Mass Index (BMI) and VAI, ultrasound guided liver biopsy and assessment of hepatic fibrosis by METAVIR staging...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965721/prospective-comparison-of-the-diagnostic-performance-of-magnetic-resonance-elastography-with-acoustic-radiation-force-impulse-elastography-for-pre-operative-staging-of-hepatic-fibrosis-in-patients-with-hepatocellular-carcinoma
#17
Chen-Te Chou, Ran-Chou Chen, Wen-Pei Wu, Ping-Yi Lin, Yao-Li Chen
The purpose of this study was to compare the diagnostic accuracy of magnetic resonance (MR) elastography with that of acoustic radiation force impulse (ARFI) elastography for pre-operative staging of hepatic fibrosis in patients with hepatocellular carcinoma. We prospectively enrolled 77 patients who were scheduled to undergo hepatectomy for hepatocellular carcinoma. Pre-operative MRE and ARFI elastography examinations were performed on the same day, and liver stiffness/velocity values were determined. Fibrosis stage and necro-inflammatory activity of resected specimens were determined histopathologically using the METAVIR scoring system...
September 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28960366/portal-pressure-and-liver-stiffness-measurements-in-the-prediction-of-fibrosis-regression-after-svr-in-recurrent-hepatitis-c
#18
Ezequiel Mauro, Gonzalo Crespo, Carla Montironi, Maria-Carlota Londoño, Virginia Hernández-Gea, Pablo Ruiz, Lydia Sastre, Julissa Lombardo, Zoe Mariño, Alba Díaz, Jordi Colmenero, Antoni Rimola, Juan Carlos Garcia-Pagan, Mercé Brunet, Xavier Forns, Miquel Navasa
Sustained virological response (SVR) improves survival in post liver transplant (LT) recurrent hepatitis C. However, the impact of SVR on fibrosis regression is not well defined. In addition, the performance of noninvasive methods to evaluate the presence of fibrosis and portal hypertension after SVR has been scarcely evaluated. We aimed to investigate the degree of fibrosis regression (decrease ≥1 METAVIR stage) after SVR and its associated factors in recurrent hepatitis C, as well as the diagnostic capacity of noninvasive methods in the assessment of liver fibrosis and portal hypertension after viral clearance...
September 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28951779/cd4-t-cells-and-natural-killer-cells-biomarkers-for-hepatic-fibrosis-in-human-immunodeficiency-virus-hepatitis-c-virus-coinfected-patients
#19
Natalia Laufer, Diego Ojeda, María Laura Polo, Ana Martinez, Héctor Pérez, Gabriela Turk, Pedro Cahn, Norberto Walter Zwirner, Jorge Quarleri
AIM: To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. METHODS: Peripheral mononuclear cells from 24 HIV/HCV (HBV negative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4...
September 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28932298/expression-of-hnrnpk-claudin-4-in-hcv-induced-early-hcc-and-adjacent-liver-tissue
#20
Olfat Hammam, Mona Magdy, Amgad Anas, Ali Abdel Rahim, Mohamed Heedaya, Ahmed Helmy
BACKGROUND: HCC in Egypt usually occurs in HCV cirrhotic livers with poor prognosis due to late diagnosis. High hnRNPK & low Claudin-4 profiles indicate Epithelial Mesenchymal Transition (EMT), malignant transformation and high-grade tumours. AIM: We studied the immunohistochemical expression of hnRNPK and Claudin-4 in HCV induced early HCC (eHCC) and adjacent liver tissue in Egyptian patients to improve eHCC detection in cirrhotic livers with better curative therapy options...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
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