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https://www.readbyqxmd.com/read/28902338/confluent-endpoint-subthreshold-argon-laser-for-serous-macular-detachment-in-tilted-disc-syndrome-refractory-to-anti-vegf
#1
Maria Fernanda Abalem, Pedro Carlos Carricondo, Helen Nazareth Veloso Dos Santos, Rafael Garcia, Cynthia X Qian, John Helal, Eduardo Cunha de Souza, Walter Yukihiko Takahashi
A 70-year-old woman presented with 20/200 visual acuity in the right eye. Multimodal imaging revealed tilted disc syndrome (TDS) with macular serous detachment (MSD) and pigmentary changes at the temporal margin of the optic disc. Subretinal fluid persisted after three monthly intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA) injections and threshold focal laser photocoagulation. Subsequently, confluent subthreshold argon laser was applied over the entire area of retinal pigment epithelium (RPE) abnormalities, resulting in the resolution of subretinal fluid without recurrence through 3 years of follow-up...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28880961/experimental-verification-of-subthreshold-laser-therapy-using-conventional-pattern-scan-laser
#2
Tomoyasu Shiraya, Satoshi Kato, Fumiyuki Araki, Takashi Ueta, Hitoshi Abe, Nobuharu Asai
PURPOSE: Leading-edge therapeutic laser technologies are not available at every medical facility; therefore, alternative approaches incorporating novel advances in digital and laser technology into more readily available conventional methods have generated significant research interest. Using a rabbit model, this study investigated whether the algorithm used in the Endpoint Management (EM) software system of the latest devices could enable subthreshold laser treatment in conventional retinal tissue laser therapy systems...
2017: PloS One
https://www.readbyqxmd.com/read/28875406/subretinal-fibrin-absorption-after-577-nm-subthreshold-micropulse-laser-therapy-in-a-csc-case-a-brief-report
#3
Lijun Zhou, Tao Li, Kunbei Lai, Chuangxin Huang, Fabao Xu, Zhe Zhu, Lin Lu, Chenjin Jin
No abstract text is available yet for this article.
September 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28831603/functional-and-morphological-outcome-in-patients-with-chronic-central-serous-chorioretinopathy-treated-by-subthreshold-micropulse-laser
#4
Maciej Gawęcki, Agnieszka Jaszczuk-Maciejewska, Anna Jurska-Jaśko, Andrzej Grzybowski
BACKGROUND: Chronic central serous chorioretinopathy is a serious therapeutic problem as it may lead to significant visual impairment. The aim of this retrospective study is to evaluate functional and morphological effects, as well as factors influencing visual outcome in patients treated by subthreshold micropulse laser. METHODS: Fifty-one eyes with chronic central serous chorioretinopathy lasting longer than 4 months (18 months on average) underwent up to two sessions of subtreshold micropulse laser treatment...
August 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#5
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28731494/subthreshold-micropulse-laser-reduces-anti-vegf-injection-burden-in-patients-with-diabetic-macular-edema
#6
Elad Moisseiev, Sam Abbassi, Sumeer Thinda, Joseph Yoon, Glenn Yiu, Lawrence S Morse
PURPOSE: To evaluate the efficacy of micropulse laser in the early treatment of diabetic macular edema (DME) and its associated burden of anti-vascular endothelial growth factor (VEGF) injections. METHODS: This retrospective comparative study compared a group of 19 eyes with DME treated with micropulse laser to a matched control group of 19 eyes with DME treated with ranibizumab injections without micropulse laser. Recorded parameters included previous medical and ocular history, previous and subsequent ranibizumab injections administered for DME, visual acuity (VA), central macular thickness throughout the follow-up period, and the occurrence of any complications...
July 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28702558/high-performance-transparent-in-plane-silicon-nanowire-fin-tfts-via-a-robust-nano-droplet-scanning-crystallization-dynamics
#7
Mingkun Xu, Jimmy Wang, Zhaoguo Xue, Junzhuan Wang, Ping Feng, Linwei Yu, Jun Xu, Yi Shi, Kunji Chen, Pere Roca I Cabarrocas
High mobility, scalable and even transparent thin-film transistors (TFTs) are always being pursued in the field of large area electronics. While excimer laser-beam-scanning can crystallize amorphous Si (a-Si) into high mobility poly-Si, it is limited to small areas. We here demonstrate a robust nano-droplet-scanning strategy that converts an a-Si:H thin film directly into periodic poly-Si nano-channels, with the aid of well-coordinated indium droplets. This enables the robust batch-fabrication of high performance Fin-TFTs with a high hole mobility of >100 cm(2) V(-1) s(-1) and an excellent subthreshold swing of only 163 mV dec(-1), via a low temperature <350 °C thin film process...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28592699/lower-affinity-of-isradipine-for-l-type-ca-2-channels-during-substantia-nigra-dopamine-neuron-like-activity-implications-for-neuroprotection-in-parkinson-s-disease
#8
Nadine J Ortner, Gabriella Bock, Antonios Dougalis, Maria Kharitonova, Johanna Duda, Simon Hess, Petronel Tuluc, Thomas Pomberger, Nadia Stefanova, Florian Pitterl, Thomas Ciossek, Herbert Oberacher, Henning J Draheim, Peter Kloppenburg, Birgit Liss, Jörg Striessnig
Ca(2+)-influx through L-type Ca(2+)-channels (LTCCs) is associated with activity-related stressful oscillations of Ca(2+) levels within dopaminergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneration in Parkinson's disease (PD). LTCC blockers were neuroprotective in mouse neurotoxin models of PD, and isradipine is currently undergoing testing in a phase III clinical trial in early PD. We report no evidence for neuroprotection by in vivo pretreatment with therapeutically relevant isradipine plasma levels, or Cav1...
July 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28540655/a-review-of-subthreshold-micropulse-laser-for-treatment-of-macular-disorders
#9
REVIEW
Paula Scholz, Lebriz Altay, Sascha Fauser
Micropulse laser treatment is an alternative to the conventional continuous-wave laser for the treatment of retinal or macular diseases. In contrast to the conventional laser, the therapeutic effect of the subthreshold micropulse laser is not accompanied by thermal retinal damage. This fact is of particular importance when a treatment near the fovea is required. Micropulse treatment is applied in indications such as central serous chorioretinopathy (CSC), diabetic macular edema (DME), or macular edema due to retinal vein occlusion (RVO)...
July 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28465531/high-performance-and-low-power-monolithic-three-dimensional-sub-50%C3%A2-nm-poly-si-thin-film-transistor-tfts-circuits
#10
Tsung-Ta Wu, Wen-Hsien Huang, Chih-Chao Yang, Hung-Chun Chen, Tung-Ying Hsieh, Wei-Sheng Lin, Ming-Hsuan Kao, Chiu-Hao Chen, Jie-Yi Yao, Yi-Ling Jian, Chiung-Chih Hsu, Kun-Lin Lin, Chang-Hong Shen, Yu-Lun Chueh, Jia-Min Shieh
Development of manufacture trend for TFTs technologies has focused on improving electrical properties of films with the cost reduction to achieve commercialization. To achieve this goal, high-performance sub-50 nm TFTs-based MOSFETs with ON-current (Ion)/subthreshold swing (S.S.) of 181 µA/µm/107 mV/dec and 188 µA/µm/98 mV/dec for NMOSFETs and PMOSFETs in a monolithic 3D circuit were demonstrated by a low power with low thermal budget process. In addition, a stackable static random access memory (SRAM) integrated with TFTs-based MOSFET with static noise margins (SNM) equals to 390 mV at VDD = 1...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419399/low-fluence-photodynamic-therapy-versus-graded-subthreshold-transpupillary-thermotherapy-for-chronic-central-serous-chorioretinopathy-results-from-a-prospective-study
#11
George J Manayath, Smita S Karandikar, Siddharth Narendran, Karan A Kumarswamy, V R Saravanan, Rodney J Morris, Narendran Venkatapathy
BACKGROUND AND OBJECTIVE: The authors compare low fluence photodynamic therapy (PDT) against graded subthreshold transpupillary thermotherapy (TTT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: Forty-two eyes of 42 patients with chronic CSC were included in this prospective, nonrandomized, interventional trial. All patients were offered PDT as an initial intervention. If they declined PDT, TTT was offered. RESULTS: Twenty patients underwent PDT and 22 underwent TTT...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28380779/monolithic-integration-of-ingaas-n-fets-and-lasers-on-ge-substrate
#12
Annie Kumar, Shuh-Ying Lee, Sachin Yadav, Kian Hua Tan, Wan Khai Loke, Satrio Wicaksono, Daosheng Li, Saeid Masudy Panah, Gengchiau Liang, Soon-Fatt Yoon, Xiao Gong, Dimitri Antoniadis, Yee-Chia Yeo
We report the first monolithic integration of InGaAs channel field-effect transistors with InGaAs/GaAs multiple quantum wells (MQWs) lasers on a common platform, achieving a milestone in the path of enabling low power and high speed opto-electronic integrated circuits (OEICs). The III-V layers used for realizing transistors and lasers were grown epitaxially on the Ge substrate using molecular beam epitaxy (MBE). A Si-CMOS compatible process was developed to realize InGaAs n-FETs with subthreshold swing SS of 93 mV/decade, I<sub>ON</sub>/I<sub>OFF</sub> ratio of more than 4 orders of magnitude with very low off-state leakage current, and a peak effective mobility of more than 2000 cm<sup>2</sup>/V·s...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28378980/subthreshold-micropulse-yellow-577-nm-laser-therapy-of-diabetic-macular-oedema-in-rural-and-urban-patients-of-south-eastern-poland
#13
Małgorzata Latalska, Agata Prokopiuk, Dominika Wróbel-Dudzińska, Jerzy Mackiewicz
Objectiv. To evaluate the efficacy of subthreshold micropulse yellow (577 nm) laser photocoagulation in diffuse macular edema (DME) in rural and urban patients of south-eastern Poland. MATERIALS AND METHOD: Seventy-five eyes of 75 patients with diffuse DME were treated with subthreshold micropulse yellow laser photocoagulation with a 5% duty cycle at an energy level. The laser exposure time was 20 ms and the spot diameter was 100 μm. Best corrected visual acuity (BCVA), reading vision (Snellen) and optical coherence tomography-determined central retinal thickness (CRT) were estimated before and 2, 4 and 6 months after laser treatment...
March 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28291205/-transpupillary-laser-photocoagulation-of-ocular-fundus-history-the-present-and-the-future
#14
A V Ardamakova, A V Bol'shunov, T S Il'ina, N A Fedoruk, V I Siplivyi
The present review covers the use of chorioretinal photocoagulation, which is now a popular treatment for many diseases of the ocular fundus. The review includes a detailed 50-year history of the technology with account to both Russian and foreign achievements. The current state of the field is shown through Russian and foreign literature data. A particular emphasis is placed on subthreshold, pattern, and navigated techniques. Breakthrough solutions, such as optoacoustic monitoring, that ensure high precision of the procedure, maximum saving of tissues, and high therapeutic effectiveness are described...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28185205/a-review-of-subthreshold-micropulse-laser-and-recent-advances-in-retinal-laser-technology
#15
REVIEW
Daniel Su, Jean-Pierre Hubschman
The role of retinal photocoagulation as a first line therapy for various retinal pathologies has decreased with the introduction of anti-vascular endothelial growth factor therapy. However, retinal laser therapy remains an important treatment modality, especially with the emergence of micropulse subthreshold treatment and the integration of newer technology such as augmented reality and semi-automated delivery. This review summarizes current evidence for micropulse laser as a treatment modality and discusses the role of new technology such as augmented reality in the future of laser therapy...
June 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28145971/subthreshold-laser-treatment-for-serous-retinal-detachment-in-dome-shaped-macula-associated-with-pathologic-myopia
#16
Maurizio Battaglia Parodi, Pierluigi Iacono, Francesco Bandello
PURPOSE: To evaluate the effects of the subthreshold laser treatment as a therapeutic option in the treatment of serous retinal detachment secondary to dome-shaped macula. METHODS: Prospective pilot study with 12-month follow-up. Each patient underwent a complete ophthalmologic examination, including best-corrected visual acuity, fluorescein angiography, indocyanine green angiography, and spectral domain optical coherence tomography. Eyes with persistent serous retinal detachment lasting for a minimum of 12 months and absence of best-corrected visual acuity improvement underwent subthreshold laser treatment in a single session...
January 31, 2017: Retina
https://www.readbyqxmd.com/read/27896311/interfacing-with-neural-activity-via-femtosecond-laser-stimulation-of-drug-encapsulating-liposomal-nanostructures
#17
Takashi Nakano, Sean M Mackay, Eng Wui Tan, Keshav M Dani, Jeff Wickens
External control over rapid and precise release of chemicals in the brain potentially provides a powerful interface with neural activity. Optical manipulation techniques, such as optogenetics and caged compounds, enable remote control of neural activity and behavior with fine spatiotemporal resolution. However, these methods are limited to chemicals that are naturally present in the brain or chemically suitable for caging. Here, we demonstrate the ability to interface with neural functioning via a wide range of neurochemicals released by stimulating loaded liposomal nanostructures with femtosecond lasers...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27830205/comparison-of-subthreshold-diode-laser-micropulse-therapy-versus-conventional-photocoagulation-laser-therapy-as-primary-treatment-of-diabetic-macular-edema
#18
Farhad Fazel, Majid Bagheri, Khodayar Golabchi, Hamidreza Jahanbani Ardakani
PURPOSE: The aim of the present study was to investigate the effect of subthreshold diode laser micropulse (SDM) in comparison with conventional laser photocoagulation in the treatment of the diabetic macular edema (DME). METHODS: Sixty-eight eyes from 68 patients with clinically significant DME were divided randomly into two equal groups. In the first group, SDM photocoagulation was employed, while conventional laser photocoagulation was performed on the eyes of the second group...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27813528/response-to-comment-on-comparison-of-subthreshold-micropulse-laser-577%C3%A2-nm-treatment-and-half-dose-photodynamic-therapy-in-patients-with-chronic-central-serous-chorioretinopathy
#19
COMMENT
https://www.readbyqxmd.com/read/27813516/comment-on-comparison-of-subthreshold-micropulse-laser-577%C3%A2-nm-treatment-and-half-dose-photodynamic-therapy-in-patients-with-chronic-central-serous-chorioretinopathy
#20
COMMENT
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