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https://www.readbyqxmd.com/read/29696993/comparison-of-ranibizumab-and-subthreshold-micropulse-laser-in-treatment-of-macular-edema-secondary-to-branch-retinal-vein-occlusion
#1
Yelda Buyru Özkurt, Sezen Akkaya, Sibel Aksoy, Mert Hakan Şimşek
PURPOSE: To compare the effects of intravitreal ranibizumab injection and yellow (577 nm) subthreshold micropulse laser treatment in patients with macular edema following non-ischemic branch retinal vein occlusion. METHODS: The medical records of 51 patients who underwent intravitreal ranibizumab (0.5 mg) injection or subthreshold micropulse laser for the treatment of macular edema due to branch retinal vein occlusion were retrospectively reviewed. Subthreshold micropulse laser was administered with a 10% duty cycle, 100 μm spot diameter, 200 ms exposure time...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29689025/combination-therapy-of-intravitreal-ranibizumab-and-subthreshold-micropulse-photocoagulation-for-macular-edema-secondary-to-branch-retinal-vein-occlusion-6-month-result
#2
Hiroko Terashima, Hiruma Hasebe, Fumiki Okamoto, Naoki Matsuoka, Yayoi Sato, Takeo Fukuchi
PURPOSE: To determine the efficacy of the combination therapy of intravitreal ranibizumab (IVR) and 577-nm yellow laser subthreshold micropulse laser photocoagulation (SMLP) for macular edema secondary to branch retinal vein occlusion cystoid macular edema. METHODS: Retrospective, consecutive, case-control study. Forty-six eyes of 46 patients with treatment-naive branch retinal vein occlusion cystoid macular edema were enrolled. The IVR + SMLP group consisted of 22 patients who had undergone both SMLP and IVR...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29651345/subthreshold-photocoagulation-using-endpoint-management-in-the-pascal%C3%A2-system-for-diffuse-diabetic-macular-edema
#3
Masafumi Hamada, Kishiko Ohkoshi, Keiji Inagaki, Nobuyuki Ebihara, Akira Murakami
We evaluated subthreshold photocoagulation using endpoint management (EPM) for the treatment of diabetic macular edema (DME). The study enrolled 10 eyes from 10 patients (6 men and 4 women) with DME. The entry criteria included central macular thickness (CMT) ≥ 300  μ m and decimal visual acuity (VA) ≤ 0.5. The primary endpoints were VA (logMAR) and CMT at 6 months follow-up. Secondary endpoints included fundus autofluorescence, macular volume (MV), and macular sensitivity (MS). We used the PASCAL Streamline Yellow® (wavelength, 577 nm) system to perform grid pattern laser photocoagulation at 50% of the threshold (size, 100  μ m; duration, 0...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29449615/improved-retinal-and-visual-function-following-panmacular-subthreshold-diode-micropulse-laser-for-retinitis-pigmentosa
#4
Jeffrey K Luttrull
OBJECTIVES: To examine the effect of subthreshold diode micropulse laser (SDM) on pattern electroretinography (PERG) and visual function in retinitis pigmentosa (RP). METHODS: The records of all patients (pts) undergoing SDM in a vitreoretinal subspecialty practice were reviewed. Inclusion criteria included the presence of RP evaluated before and after SDM by PERG. As a secondary outcome measure, the results of automated omnifield resolution perimetry (ORP) were also reviewed...
February 16, 2018: Eye
https://www.readbyqxmd.com/read/29448683/using-krf-ela-to-improve-gate-stacked-laalo%C3%A2-zro%C3%A2-indium-gallium-zinc-oxide-thin-film-transistors-with-novel-atmospheric-pressure-plasma-enhanced-chemical-vapor-deposition-technique
#5
Chien-Hung Wu, Kow-Ming Chang, Yi-Ming Chen, Bo-Wen Huang, Yu-Xin Zhang, Shui-Jinn Wang
Atmospheric pressure plasma-enhanced chemical vapor deposition (AP-PECVD) technique and KrF excimer laser annealing (ELA) were employed for the fabrication of indium gallium zinc oxide thin-film transistors (IGZO-TFTs). Device with a 150 mJ/cm2 laser annealing densities demonstrated excellent electrical characteristics with improved on/off current ratio of 4.7×107, high channel mobility of 10 cm2/V-s, and low subthreshold swing of 0.15 V/dec. The improvements are attributed to the adjustment of oxygen vacancies in the IGZO channel to an appropriate range of around 28...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29392319/nanosecond-laser-treatment-for-age-related-macular-degeneration-does-not-induce-focal-vision-loss-or-new-vessel-growth-in-the-retina
#6
Kirstan A Vessey, Tracy Ho, Andrew I Jobling, Samuel A Mills, Mai X Tran, Alice Brandli, Jackson Lam, Robyn H Guymer, Erica L Fletcher
Purpose: Subthreshold, nanosecond pulsed laser treatment shows promise as a treatment for age-related macular degeneration (AMD); however, the safety profile needs to be robustly examined. The aim of this study was to investigate the effects of laser treatment in humans and mice. Methods: Patients with AMD were treated with nanosecond pulsed laser at subthreshold (no visible retinal effect) energy doses (0.15-0.45 mJ) and retinal sensitivity was assessed with microperimetry...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29391774/subthreshold-microsecond-laser-for-proliferative-diabetic-retinopathy-a-randomized-pilot-study
#7
Mahima Jhingan, Abhilash Goud, Hari Kumar Peguda, Mitali Khodani, Jeffrey K Luttrull, Jay Chhablani
Aim: To compare the outcomes of subthreshold microsecond (STM) and continuous-wave laser (CWL) panretinal photocoagulation (PRP). Methods: In this randomized, prospective, pilot study, 20 eyes of 10 subjects with symmetric severe non-proliferative (NPDR) or low-risk proliferative diabetic retinopathy (PDR) were included. Each eye of the subject was randomized into either CWL or STM PRP group. Patients were evaluated at baseline and at months 3, 6, and 9 with color fundus photographs and visual field tests at each visit; however, electroretinography (ERG) was conducted at baseline and at month 9...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29245855/integration-of-ingaas-mosfets-and-gaas-algaas-lasers-on-si-substrate-for-advanced-opto-electronic-integrated-circuits-oeics
#8
Annie Kumar, Shuh-Ying Lee, Sachin Yadav, Kian Hua Tan, Wan Khai Loke, Yuan Dong, Kwang Hong Lee, Satrio Wicaksono, Gengchiau Liang, Soon-Fatt Yoon, Dimitri Antoniadis, Yee-Chia Yeo, Xiao Gong
Lasers monolithically integrated with high speed MOSFETs on the silicon (Si) substrate could be a key to realize low cost, low power, and high speed opto-electronic integrated circuits (OEICs). In this paper, we report the monolithic integration of InGaAs channel transistors with electrically pumped GaAs/AlGaAs lasers on the Si substrate for future advanced OEICs. The laser and transistor layers were grown on the Si substrate by molecular beam epitaxy (MBE) using direct epitaxial growth. InGaAs n-FETs with an ION /IOFF ratio of more than 106 with very low off-state leakage and a low subthreshold swing with a minimum of 82 mV/decade were realized...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29177712/laser-photocoagulation-as-treatment-of-non-exudative-age-related-macular-degeneration-state-of-the-art-and-future-perspectives
#9
REVIEW
Giuseppe Querques, Maria Vittoria Cicinelli, Alessandro Rabiolo, Luigi de Vitis, Riccardo Sacconi, Lea Querques, Francesco Bandello
PURPOSE: To give an updated review of laser approaches to non-exudative age-related macular degeneration (AMD). METHODS: PubMed and Medline database searches were carried out using the terms "laser" and "photocoagulation" associated with "age-related macular degeneration", and latest publications up to May 2017 have been reviewed. Moreover, the design of an ongoing single-center, non-randomized, phase I-II, pilot study, the PASCAL-GA trial, coordinated by F...
January 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29091878/subthreshold-diode-micropulse-laser-versus-conventional-laser-photocoagulation-monotherapy-or-combined-with-anti-vegf-therapy-for-diabetic-macular-edema-a-bayesian-network-meta-analysis
#10
REVIEW
Ying Wu, Pu Ai, Zisheng Ai, Guotong Xu
AIMS: To assess the effects of laser photocoagulation as monotherapy or adjuvant therapy for the treatment of DME. METHODS: A search of the Cochrane Library, Pubmed, Embase, and the clinicaltrial.gov registry for randomized clinical trials comparing any two treatments of interest (SDMLP monotherapy, CLP monotherapy, CLP plus anti-VEGF therapy) was performed. Data were collected and pooled by Bayesian network meta-analyses which accounts for both direct and indirect comparisons...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29049716/bone-marrow-derived-cell-recruitment-to-the-neurosensory-retina-and-retinal-pigment-epithelial-cell-layer-following-subthreshold-retinal-phototherapy
#11
Sergio Caballero, David L Kent, Nilanjana Sengupta, Sergio Li Calzi, Lynn Shaw, Eleni Beli, Leni Moldovan, James M Dominguez, Ramana S Moorthy, Maria B Grant
Purpose: We investigated whether subthreshold retinal phototherapy (SRPT) was associated with recruitment of bone marrow (BM)-derived cells to the neurosensory retina (NSR) and RPE layer. Methods: GFP chimeric mice and wild-type (WT) mice were subjected to SRPT using a slit-lamp infrared laser. Duty cycles of 5%, 10%, 15%, and 20% (0.1 seconds, 250 mW, spot size 50 μm) with 30 applications were placed 50 to 100 μm from the optic disc. In adoptive transfer studies, GFP+ cells were given intravenously immediately after WT mice received SRPT...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28902338/confluent-endpoint-subthreshold-argon-laser-for-serous-macular-detachment-in-tilted-disc-syndrome-refractory-to-anti-vegf
#12
Maria Fernanda Abalem, Pedro Carlos Carricondo, Helen Nazareth Veloso Dos Santos, Rafael Garcia, Cynthia X Qian, John Helal, Eduardo Cunha de Souza, Walter Yukihiko Takahashi
A 70-year-old woman presented with 20/200 visual acuity in the right eye. Multimodal imaging revealed tilted disc syndrome (TDS) with macular serous detachment (MSD) and pigmentary changes at the temporal margin of the optic disc. Subretinal fluid persisted after three monthly intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA) injections and threshold focal laser photocoagulation. Subsequently, confluent subthreshold argon laser was applied over the entire area of retinal pigment epithelium (RPE) abnormalities, resulting in the resolution of subretinal fluid without recurrence through 3 years of follow-up...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28880961/experimental-verification-of-subthreshold-laser-therapy-using-conventional-pattern-scan-laser
#13
Tomoyasu Shiraya, Satoshi Kato, Fumiyuki Araki, Takashi Ueta, Hitoshi Abe, Nobuharu Asai
PURPOSE: Leading-edge therapeutic laser technologies are not available at every medical facility; therefore, alternative approaches incorporating novel advances in digital and laser technology into more readily available conventional methods have generated significant research interest. Using a rabbit model, this study investigated whether the algorithm used in the Endpoint Management (EM) software system of the latest devices could enable subthreshold laser treatment in conventional retinal tissue laser therapy systems...
2017: PloS One
https://www.readbyqxmd.com/read/28875406/subretinal-fibrin-absorption-after-577-nm-subthreshold-micropulse-laser-therapy-in-a-csc-case-a-brief-report
#14
Lijun Zhou, Tao Li, Kunbei Lai, Chuangxin Huang, Fabao Xu, Zhe Zhu, Lin Lu, Chenjin Jin
No abstract text is available yet for this article.
September 5, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28831603/functional-and-morphological-outcome-in-patients-with-chronic-central-serous-chorioretinopathy-treated-by-subthreshold-micropulse-laser
#15
Maciej Gawęcki, Agnieszka Jaszczuk-Maciejewska, Anna Jurska-Jaśko, Andrzej Grzybowski
BACKGROUND: Chronic central serous chorioretinopathy is a serious therapeutic problem as it may lead to significant visual impairment. The aim of this retrospective study is to evaluate functional and morphological effects, as well as factors influencing visual outcome in patients treated by subthreshold micropulse laser. METHODS: Fifty-one eyes with chronic central serous chorioretinopathy lasting longer than 4 months (18 months on average) underwent up to two sessions of subtreshold micropulse laser treatment...
December 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#16
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28731494/subthreshold-micropulse-laser-reduces-anti-vegf-injection-burden-in-patients-with-diabetic-macular-edema
#17
Elad Moisseiev, Sam Abbassi, Sumeer Thinda, Joseph Yoon, Glenn Yiu, Lawrence S Morse
PURPOSE: To evaluate the efficacy of micropulse laser in the early treatment of diabetic macular edema (DME) and its associated burden of anti-vascular endothelial growth factor (VEGF) injections. METHODS: This retrospective comparative study compared a group of 19 eyes with DME treated with micropulse laser to a matched control group of 19 eyes with DME treated with ranibizumab injections without micropulse laser. Recorded parameters included previous medical and ocular history, previous and subsequent ranibizumab injections administered for DME, visual acuity (VA), central macular thickness throughout the follow-up period, and the occurrence of any complications...
July 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28702558/high-performance-transparent-in-plane-silicon-nanowire-fin-tfts-via-a-robust-nano-droplet-scanning-crystallization-dynamics
#18
Mingkun Xu, Jimmy Wang, Zhaoguo Xue, Junzhuan Wang, Ping Feng, Linwei Yu, Jun Xu, Yi Shi, Kunji Chen, Pere Roca I Cabarrocas
High mobility, scalable and even transparent thin-film transistors (TFTs) are always being pursued in the field of large area electronics. While excimer laser-beam-scanning can crystallize amorphous Si (a-Si) into high mobility poly-Si, it is limited to small areas. We here demonstrate a robust nano-droplet-scanning strategy that converts an a-Si:H thin film directly into periodic poly-Si nano-channels, with the aid of well-coordinated indium droplets. This enables the robust batch-fabrication of high performance Fin-TFTs with a high hole mobility of >100 cm(2) V(-1) s(-1) and an excellent subthreshold swing of only 163 mV dec(-1), via a low temperature <350 °C thin film process...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28592699/lower-affinity-of-isradipine-for-l-type-ca-2-channels-during-substantia-nigra-dopamine-neuron-like-activity-implications-for-neuroprotection-in-parkinson-s-disease
#19
Nadine J Ortner, Gabriella Bock, Antonios Dougalis, Maria Kharitonova, Johanna Duda, Simon Hess, Petronel Tuluc, Thomas Pomberger, Nadia Stefanova, Florian Pitterl, Thomas Ciossek, Herbert Oberacher, Henning J Draheim, Peter Kloppenburg, Birgit Liss, Jörg Striessnig
Ca(2+)-influx through L-type Ca(2+)-channels (LTCCs) is associated with activity-related stressful oscillations of Ca(2+) levels within dopaminergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneration in Parkinson's disease (PD). LTCC blockers were neuroprotective in mouse neurotoxin models of PD, and isradipine is currently undergoing testing in a phase III clinical trial in early PD. We report no evidence for neuroprotection by in vivo pretreatment with therapeutically relevant isradipine plasma levels, or Cav1...
July 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28540655/a-review-of-subthreshold-micropulse-laser-for-treatment-of-macular-disorders
#20
REVIEW
Paula Scholz, Lebriz Altay, Sascha Fauser
Micropulse laser treatment is an alternative to the conventional continuous-wave laser for the treatment of retinal or macular diseases. In contrast to the conventional laser, the therapeutic effect of the subthreshold micropulse laser is not accompanied by thermal retinal damage. This fact is of particular importance when a treatment near the fovea is required. Micropulse treatment is applied in indications such as central serous chorioretinopathy (CSC), diabetic macular edema (DME), or macular edema due to retinal vein occlusion (RVO)...
July 2017: Advances in Therapy
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