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https://www.readbyqxmd.com/read/29917214/safety-and-efficacy-of-tigecycline-in-complicated-and-uncomplicated-pelvic-inflammatory-disease
#1
A Perutelli, C Tascini, L Domenici, S Garibaldi, C Baroni, E Cecchi, M G Salerno
OBJECTIVE: Tigecycline is a glycylcycline antimicrobial structurally related to minocycline, with a wide spectrum of activity that includes anaerobes and typical and atypical microorganisms causing pelvic inflammatory disease (PID). This study aimed to evaluate efficacy and safety of tigecycline in complicated PID and un-complicated PID after the failure of first-line antibiotic therapy. PATIENTS AND METHODS: Between May 2014 and April 2016 at the 2nd Unit of Obstetrics and Gynecology, Santa Chiara Hospital of Pisa a pilot study on 20 women with mild/moderate PID after the failure of first-line antibiotic therapy and on 8 women with complicated PID was conducted...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917037/high-plasma-apolipoprotein-b-identifies-obese-subjects-who-best-ameliorate-white-adipose-tissue-dysfunction-and-glucose-induced-hyperinsulinemia-after-a-hypocaloric-diet
#2
Simon Bissonnette, Nathalie Saint-Pierre, Valerie Lamantia, Catherine Leroux, Viviane Provost, Yannick Cyr, Remi Rabasa-Lhoret, May Faraj
Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29915948/thyroid-hormone-receptor-beta-1-expression-in-early-breast-cancer-a-validation-study
#3
K J Jerzak, J G Cockburn, S K Dhesy-Thind, G R Pond, K I Pritchard, S Nofech-Mozes, P Sun, S A Narod, A Bane
PURPOSE: Preliminary data suggest that high expression of the TRβ1 tumor suppressor is associated with longer survival among women with early breast cancer. We undertook this study to validate these findings. METHODS: In this prospective cohort study, we analyzed the prognostic significance of TRβ1 protein expression in the breast tumors of 796 women who had undergone breast surgery in the Henrietta Banting Breast Cancer database. All women were recruited after undergoing primary surgical therapy at Women's College Hospital (Toronto, ON, Canada) between January 1987 and December 2000...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29915825/multi-functional-derivatization-of-amine-hydroxyl-and-carboxylate-groups-for-metabolomic-investigations-of-human-tissue-by-electrospray-ionization-mass-spectrometry
#4
Tianjiao Huang, Maria Toro, Richard Lee, Dawn S Hui, James L Edwards
Metabolomics, the study of small molecules involved in cellular processes, offers the potential to reveal insights into the pathophysiology of disease states. Analysis of metabolites by electrospray mass spectrometry is complicated by their structural diversity. Amine, hydroxyl, and carboxylate groups all affect signal responses differently based on their polarity and proton affinity. This heterogeneity of signal response, sensitivity, and resistance to competing ionization complicates metabolite quantitation...
June 19, 2018: Analyst
https://www.readbyqxmd.com/read/29915666/evaluation-of-amnion-derived-mesenchymal-stem-cells-for-treatment-resistant-moderate-crohn-s-disease-study-protocol-for-a-phase-i-ii-dual-centre-open-label-uncontrolled-dose-response-trial
#5
Shinsuke Otagiri, Shunsuke Ohnishi, Arisa Miura, Hiroshi Hayashi, Izumi Kumagai, Yoichi M Ito, Takehiko Katsurada, Shiro Nakamura, Rika Okamoto, Kenichi Yamahara, Kyu Yong Cho, Toshiyuki Isoe, Norihiro Sato, Naoya Sakamoto
Introduction: The medical treatment options for patients with Crohn's disease (CD) are limited and patients resistant to those therapies are left requiring surgical operations that usually only achieve some symptomatic relief. Mesenchymal stem cells (MSC) have been shown to be effective for the treatment of CD, and we have demonstrated in animal experiments that human amnion-derived MSCs (AMSC) are a potential new therapeutic strategy. Therefore, we designed this study to investigate the safety and efficacy of AMSCs in patients with treatment-resistant CD...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29914954/ten-day-quadruple-therapy-comprising-low-dose-rabeprazole-bismuth-amoxicillin-and-tetracycline-is-an-effective-and-safe-first-line-treatment-for-helicobacter-pylori-infection-in-population-with-high-antibiotic-resistance-a-prospective-multicenter-randomized
#6
Yong Xie, Zhenhua Zhu, Jiangbin Wang, Lingxia Zhang, Zhenyu Zhang, Hong Lu, Zhirong Zeng, Shiyao Chen, Dongsheng Liu, Nonghua Lv
Objectives: To investigate the efficacy and safety of 10-day bismuth quadruple therapy with amoxicillin, tetracycline or clarithromycin and different doses of rabeprazole for first-line treatment of Helicobacter pylori infection. Methods: This multicenter, randomized, parallel-controlled clinical trial was conducted between March 2013 and August 2014. A total of 431 H. pylori -infected patients with duodenal ulcers were enrolled and randomized into four treatment groups (1:1:1:1) for 10 days: 1. LR-BAC Group, which received rabeprazole 10 mg b...
June 18, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29914933/cgmp-dependent-protein-kinase-2-regulates-bone-mass-and-prevents-diabetic-bone-loss
#7
Ghania Ramdani, Nadine Schall, Hema Kalyanaraman, Nisreen Wahwah, Sahar Moheize, Jenna J Lee, Robert L Sah, Alexander Pfeifer, Darren E Casteel, Renate B Pilz
NO/cGMP signaling is important for bone remodeling in response to mechanical and hormonal stimuli, but the downstream mediator(s) regulating skeletal homeostasis are incompletely defined. We generated transgenic mice expressing a partly-activated, mutant cGMP-dependent protein kinase type 2 (PKG2R242Q ) under control of the osteoblast-specific Col1a1 promoter to characterize the role of PKG2 in post-natal bone formation. Primary osteoblasts from these mice showed a 2- to 3-fold increase in basal and total PKG2 activity; they proliferated faster and were resistant to apoptosis compared to cells from wild type mice...
June 18, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29914886/blocking-tir-domain-interactions-in-tlr9-signaling
#8
Artur Javmen, Henryk Szmacinski, Joseph R Lakowicz, Vladimir Y Toshchakov
Interaction of TLR9 with ligands activates NF-κB, leading to proinflammatory cytokine production. Excessive TLR activation is a pathogenic factor for inflammatory diseases. This study has examined cell-permeating decoy peptides (CPDPs) derived from the TLR9 Toll/IL-1R resistance (TIR) domain. CPDP 9R34, which included AB loop, β-strand B, and N-terminal BB loop residues, inhibited TLR9 signaling most potently. CPDPs derived from α-helices C, D, and E (i.e., 9R6, 9R9, and 9R11) also inhibited TLR9-induced cytokines but were less potent than 9R34...
June 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29914880/antibiotic-prescribing-for-acute-respiratory-tract-infections-in-primary-care-an-updated-and-expanded-meta-ethnography
#9
Evi Germeni, Julia Frost, Ruth Garside, Morwenna Rogers, Jose M Valderas, Nicky Britten
BACKGROUND: Reducing unnecessary prescribing remains a key priority for tackling the global rise of antibiotic-resistant infections. AIM: The authors sought to update a 2011 qualitative synthesis of GPs' experiences of antibiotic prescribing for acute respiratory tract infections (ARTIs), including their views of interventions aimed at more prudent prescribing. They expanded the original scope to encompass all primary care professionals (PCPs) who can prescribe or dispense antibiotics for ARTIs (for example, nurses and pharmacists)...
June 18, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29914436/treatment-in-the-stampede-era-for-castrate-resistant-prostate-cancer-in-the-uk-ongoing-challenges-and-underappreciated-clinical-problems
#10
Rosa U Greasley, Rebecca Turner, Karen Collins, Janet Brown, Liam Bourke, Derek J Rosario
BACKGROUND: This study aimed to explore the opinions of healthcare professionals regarding the management of men with advanced prostate cancer with particular emphasis on treatment timing and sequencing; treatment adverse-effects and exercise a supportive therapy. METHODS: Semi-structured interviews with a purposively selected group of healthcare professionals involved in prostate cancer care within the NHS, conducted over the phone or face to face. A total of 37 healthcare professionals participated in the interviews including urologists, clinical oncologists, medical oncologists, clinical nurse specialists, general practitioners, physiotherapists, exercise specialists, service managers, clinical commissioners and primary care physicians...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29914385/tonsillar-plasmacytoma-clues-on-magnetic-resonance-imaging
#11
İrfan Çelebi, Gülpembe Bozkurt, Nedim Polat
BACKGROUND: Malignant plasma cell proliferation may present as a disseminated disease (multiple myeloma), a solitary plasmacytoma of bone, or an extramedullary plasmacytoma of soft tissue. The latter plasmacytomas represent approximately 3% of all plasma cell proliferations, and 80% develop in the head-and-neck region. The unexpected clinical presentation of such masses may be present. CASE PRESENTATION: Here, we report a rare case of primary tonsillar plasmacytoma in a 42-year-old female...
June 18, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29912996/the-pharmacokinetic-properties-of-glucagon-like-peptide-1-receptor-agonists-and-their-mode-and-mechanism-of-action-in-patients-with-type-2-diabetes
#12
John Anderson
Once-weekly (OW) glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated improved glycemic control in patients with type 2 diabetes (T2D), and some have a number of other benefits, including weight loss, improvements in blood pressure and lipid profiles, and cardiovascular protection. They also provide a therapy option with a low risk of hypoglycemia, an attractive choice for many patients. Molecular structure and pharmacokinetic properties vary among GLP-1 RAs, with some more closely related than others to native glucagon-like peptide-1 (GLP-1)...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912596/understanding-resistance-mechanisms-to-btk-and-bcl2-inhibitors-in-mantle-cell-lymphoma-implications-for-design-of-clinical-trials
#13
Rishu Agarwal, Mark A Dawson, Martin Dreyling, Constantine S Tam
Novel targeted therapeutics has significantly improved the outlook of patients with relapsed/refractory mantle cell lymphoma (R/R MCL). Despite significant efficacy, one of the major limitations of these targeted agents is presence of primary or acquired resistance to these novel drugs. Patients who fail primary therapy especially with ibrutinib have poor outcomes and may respond poorly to subsequent therapies. Hence, it is important to understand resistance mechanisms a priori to identify patients who are unlikely to respond, and to explore alternative therapeutic strategies...
June 18, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29912381/detection-of-pyrethroid-resistance-mutations-in-the-major-leishmaniasis-vector-phlebotomus-papatasi
#14
Emmanouil A Fotakis, Ioannis A Giantsis, Samiye Demir, John G Vontas, Alexandra Chaskopoulou
Phlebotomine sand flies (Diptera: Psychodidae) are primary vectors of leishmaniasis. Greece and Turkey are both endemic for visceral and cutaneous leishmaniasis and are widely affected by the disease. Measures commonly applied for controlling sand flies rely on the use of insecticides, predominantly pyrethroids. A worldwide problem associated with the intensive use of insecticides is the development of resistance. Scarce information is available regarding the resistance status in sand fly populations. Sand flies were collected from Greece (Thessaloniki, Peloponnese, Chios island) and Turkey (Sanliurfa) and analyzed for the presence and frequency of target-site knockdown resistance mutations on the voltage-gated sodium channel (Vgsc) gene...
April 18, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29912351/patients-with-respiratory-tract-infections-who-do-not-want-antibiotics-direct-observational-study-of-primary-care-in-poland
#15
Slawomir Chlabicz, Dorota Rogowska-Szadkowska, Barbara Pytel-Krolczuk, Ludmila Marcinowicz, Anna Justyna Milewska, Julia Strumilo
Background: Requests by patients for antibiotics are known to strongly affect doctors' decisions to prescribe them. Objective. The aim of this study was to establish how frequently patients presenting with respiratory tract infections (RTIs) express their expectation not to be treated with antibiotics, which symptoms and physical findings are related to their perception of antibiotics not being helpful, and to what degree their expectations influence doctors' decisions. Methods: This was a direct observational study set in primary care practices in Bialystok, Poland...
June 15, 2018: Family Practice
https://www.readbyqxmd.com/read/29912307/immediate-vs-deferred-switching-from-a-boosted-protease-inhibitor-pi-r-based-regimen-to-a-dolutegravir-dtg-based-regimen-in-virologically-suppressed-patients-with-high-cardiovascular-risk-or-age-%C3%A2-50-years-final-96-weeks-results-of-neat-022-study
#16
José M Gatell, Lambert Assoumou, Graeme Moyle, Laura Waters, Margaret Johnson, Pere Domingo, Julie Fox, Esteban Martinez, Hans-Jürgen Stellbrink, Giovanni Guaraldi, Mar Masia, Mark Gompels, Stephane De Wit, Eric Florence, Stefan Esser, François Raffi, Christoph Stephan, Juergen Rockstroh, Andrea Giacomelli, Jaime Vera, José Ignacio Bernardino, Alan Winston, Maria Saumoy, Julien Gras, Christine Katlama, Anton L Pozniak
Background: Both immediate or deferred switching from a PI/r to DTG may improve lipid profile. Methods: NEAT022 is a European, open label, randomized, trial. HIV-infected adults ≥ 50 years or with a Framingham score ≥10% were eligible if HIV RNA < 50 copies/mL. Patients were randomized to switch the PI/r to DTG immediately (DTG-I) or to deferred switch at week 48 (DTG-D) . Week 96 end-points were: proportion of patients with HIV RNA < 50 copies/ml, percentage change of lipid fractions and adverse events...
June 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29911761/antibiotic-exposure-in-the-community-and-resistance-patterns-of-escherichia-coli-community-acquired-bloodstream-infection
#17
Bat-Sheva Gottesman, Pnina Shitrit, Michal Katzir, Michal Chowers
BACKGROUND: Increasing antibiotic resistance in the community results in greater use of empiric broad spectrum antibiotics for patients at hospital admission. As a measure of antibiotic stewardship it is important to identify a patient population that can receive narrow spectrum antibiotics. OBJECTIVES: To evaluate resistance patterns of Escherichia coli bloodstream infection (BSI) from strictly community-acquired infection and the impact of recent antibiotic use on this resistance...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911329/helicobacter-pylori-antibiotic-resistance-in-portugal-systematic-review-and-meta-analysis
#18
REVIEW
Inês Lopo, Diogo Libânio, Inês Pita, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
BACKGROUND: Portugal presents both a high prevalence of Helicobacter pylori (Hp) infection and a high prevalence of antibiotic resistance. However, conclusive data on its magnitude are lacking. We aimed at summarizing the existing data. MATERIALS AND METHODS: A systematic review was conducted after searching in two databases (PubMed and SciELO). Meta-analysis was performed, and comparison of resistance rates between children and adults and by type of resistance (primary and secondary) was made...
June 17, 2018: Helicobacter
https://www.readbyqxmd.com/read/29911107/colorectal-cancer-genomics-and-designing-rational-trials
#19
REVIEW
Sebastian Mondaca, Rona Yaeger
The widespread use of next generation sequencing (NGS) has led to a refined understanding of the genomics of colorectal cancer (CRC). However, progress in the use of molecular biomarkers in standard practice has been slow, and there is no approved targeted therapy for CRC based on a positive predictive marker yet. In this review, we will first summarize biomarkers with clinical utility in standard practice or targeted therapy trials and then consider how to rationally design clinical trials to more effectively target CRC...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29910771/use-of-readily-accessible-inflammatory-markers-to-predict-diabetic-kidney-disease
#20
REVIEW
Lauren Winter, Lydia A Wong, George Jerums, Jas-Mine Seah, Michele Clarke, Sih Min Tan, Melinda T Coughlan, Richard J MacIsaac, Elif I Ekinci
Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the rate of progression to end-stage renal disease. Diabetic kidney disease has been traditionally classified based on the presence of albuminuria. More recently estimated glomerular filtration rate has also been incorporated into the staging of diabetic kidney disease...
2018: Frontiers in Endocrinology
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