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https://www.readbyqxmd.com/read/29659361/-one-hundred-years-after-the-spanish-flu
#1
Isabel A Lüthy, Viviana Ritacco, Isabel N Kantor
The "Spanish" flu pandemic, which occurred a century ago, is considered the most devastating in human history. An estimated one third of world population fell ill with flu and more than 2.5% of them died. The course of the epidemic had two main waves (1918 and 1919) and showed an unusual W-shaped morbidity/mortality distribution. Death was not a direct outcome of flu itself but rather a consequence of secondary bacterial bronchopneumonia, for which antibiotics had not yet been discovered. Pre-existing pulmonary tuberculosis was also accountable for increased flu death rates during the pandemic...
2018: Medicina
https://www.readbyqxmd.com/read/29648506/systemic-equid-alphaherpesvirus-9-in-a-grant-s-zebra
#2
Robert B Moeller, Beate Crossley, Arlena Pipkin, Yanqiu Li, Udeni B R Balasuriya
A 2-y-old female Grant's zebra ( Equus quagga [ burchellii] boehmi) was presented with a clinical history of depression, anorexia, and weakness of 1-wk duration. Postmortem examination identified ulcers on the tongue and palate; a large abscess adjacent to the larynx; left lung consolidation; mild swelling, darkening, and congestion of the liver with accentuation of the lobular pattern; and edema and congestion of the distal small and large intestines. Histologic examination identified necrotizing bronchopneumonia, necrotizing hepatitis, nephritis, and enterocolitis...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29619105/assessment-of-pulmonary-function-before-and-after-sinus-surgery-in-lung-transplant-recipients
#3
Bernardo Faria Ramos, Fábio de Rezende Pinna, Silvia Vidal Campos, José Eduardo Afonso Júnior, Ricardo Henrique de Oliveira Braga Teixeira, Rafael Medeiros Carraro, Richard Louis Voegels
Introduction  The association between sinus and lung diseases is well known. However, there are scarce studies regarding the effects of sinus surgery on pulmonary function in lung transplant recipients. The present study describes our experience with sinus surgery in lung transplant recipients with chronic rhinosinusitis. Objectives  To assess the impact of sinus surgery for chronic rhinosinusitis on pulmonary function and on inpatient hospitalization days due to lower respiratory tract infection in lung transplant recipients...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29593714/bacterial-and-pneumocystis-infections-in-the-lungs-of-gene-knockout-rabbits-with-severe-combined-immunodeficiency
#4
Jun Song, Guoshun Wang, Mark J Hoenerhoff, Jinxue Ruan, Dongshan Yang, Jifeng Zhang, Jibing Yang, Patrick A Lester, Robert Sigler, Michael Bradley, Samantha Eckley, Kelsey Cornelius, Kong Chen, Jay K Kolls, Li Peng, Liang Ma, Yuqing Eugene Chen, Fei Sun, Jie Xu
Using the CRISPR/Cas9 gene-editing technology, we recently produced a number of rabbits with mutations in immune function genes, including FOXN1, PRKDC, RAG1, RAG2, and IL2RG. Seven founder knockout rabbits (F0) and three male IL2RG null (-/y) F1 animals demonstrated severe combined immunodeficiency (SCID), characterized by absence or pronounced hypoplasia of the thymus and splenic white pulp, and absence of immature and mature T and B-lymphocytes in peripheral blood. Complete blood count analysis showed severe leukopenia and lymphocytopenia accompanied by severe neutrophilia...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29565255/pulmonary-and-systemic-fungal-infections-in-an-atlantic-spotted-dolphin-and-a-bryde-s-whale-brazil
#5
Kátia R Groch, Josué Díaz-Delgado, Carlos Sacristán, Denyiélim E Oliveira, Gabriela Souza, Angélica M Sánchez-Sarmiento, Samira Costa-Silva, Juliana Marigo, Pedro V Castilho, Marta J Cremer, Aline Rodrigues Hoffmann, Fernando Esperón, José L Catão-Dias
We report the gross and microscopic findings and molecular identification of 2 cases of hyphate fungal infection in cetaceans from Brazil. The first case involved an adult male Atlantic spotted dolphin Stenella frontalis with localized pulmonary disease characterized by pyogranulomatous and necrotizing bronchopneumonia with intralesional hyphae. The second case involved an adult male Bryde's whale Balaenoptera edeni with orchitis, periorchitis, mesenteric lymphadenitis and pyogranulomatous bronchopneumonia with intralesional hyphae...
March 22, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29559882/mycotic-pulmonary-artery-aneurysm-mimicking-a-rasmussen-aneurysm
#6
Stephanie C Cajigas-Loyola, Ricky L Miller, Bradley Spieler, Gregory Carbonella
Background: Mycotic aneurysms arising from the pulmonary arteries are rare; only a few cases have been reported. Staphylococcus and Streptococcus species are the most common causative pathogens. Mycotic aneurysms are seldom clinically apparent unless as a sequela of adverse procedural complications. They carry high morbidity and mortality if not treated expeditiously. Case Report: We present the case of a 37-year-old male with bacteremia and bronchopneumonia associated with a pulmonary artery mycotic aneurysm...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/29551641/histophilus-somni-associated-syndromes-in-sheep-from-southern-brazil
#7
Selwyn A Headley, Alfredo H T Pereira, Luciana C Balbo, Giovana W Di Santia, Ana P F R L Bracarense, Luiz F C Cunha Filho, Jackson Schade, Werner Okano, Priscilla F V Pereira, Fábio Morotti, Lucienne G Preto-Giordano, Rogério A Marcasso, Alice F Alfieri, Júlio A N Lisbôa, Amauri A Alfieri
Histophilus somni is a Gram-negative bacterium that is associated with a disease complex (termed histophilosis) that can produce several clinical syndromes predominantly in cattle, but also in sheep. Histophilosis is well described in North America, Canada, and in some European countries. In Brazil, histophilosis has been described in cattle with respiratory, reproductive, and systemic disease, with only one case described in sheep. This report describes the occurrence of Histophilus somni-associated disease in sheep from Southern Brazil...
March 15, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29551451/the-new-plant-parinari-kerstingii-engl-toxicity-studies-and-anti-inflammatory-properties
#8
Loveth O Linus, Shi-Lei Wang, Ning Shi, Christian Hanson, Yi-Tong Lu, Raphael N Alolga, Qun Liu, Reginald C Njokuocha, Lian-Wen Qi
ETHNOPHARMACOLOGICAL RELEVANCE: Parinari kerstingii Engl. extract is traditionally used for the treatment of inflammation, bronchopneumonia, feverish pains, and breast cancer. However, there have not been any scientific reports regarding the medicinal properties of this plant, and no experiments have been done to ascertain the safety of the extract. AIM OF THE STUDY: The objective of this work was to evaluate the toxicity of Parinari kerstingii Engl. extracts as an herbal remedy and to investigate its anti-inflammatory potential in vivo...
March 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29524496/in-vivo-efficacy-and-pharmacokinetics-of-bi-aryl-oxazolidinone-rbx-11-760-loaded-polylactic-acid-polyethylene-glycol-nanoparticles-in-mouse-hematogenous-bronchopneumonia-and-rat-groin-abscess-caused-by-staphylococcus-aureus
#9
Tarani Kanta Barman, Manoj Kumar, Tridib Chaira, Manu Dalela, Dikshi Gupta, Paras Kumar Jha, Ajay Singh Yadav, Dilip J Upadhyay, V Samuel Raj, Harpal Singh
RBx 11,760 is a bi-aryl oxazolidinone antibacterial agent active against Staphylococcus aureus but has poor solubility. Here we have encapsulated RBx 11,760 in PLA-PEG NPs with an aim to improve physicochemical, pharmacokinetics and in vivo efficacy. The average size and zeta potential of RBx 11,760 loaded NPs were found to be 106.4 nm and -22.2 mV, respectively. The absolute size of nanoparticles by HRTEM was found to be approximately 80 nm. In vitro antibacterial agar well diffusion assay showed clear zone of inhibition of bacterial growth...
March 7, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29449956/bilateral-bronchial-stent-deployment-for-palliative-treatment-of-a-compressive-intrathoracic-mass-in-a-cat
#10
Kieran Borgeat, Kerry Simpson, David Reese, Helen Wilson, Joanna Potter, Daniel Ogden
Case summary: Bronchial stents may be useful to relieve clinical signs of extraluminal compression. Herein we describe a case which, to our knowledge, is the first cat where bilateral bronchial stents have been used clinically. Respiratory signs of principal bronchial compression were alleviated after the stent procedure. Minor complications occurred, specifically: severe hypoxia during stent deployment; a transient, self-limiting postoperative pneumothorax possibly associated with ventilation-induced lung injury; bronchopneumonia (possibly pre-existing); and transient worsening of cough postoperatively...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29437754/epidemiological-and-clinical-features-of-human-metapneumovirus-in-hospitalised-paediatric-patients-with-acute-respiratory-illness-a-cross-sectional-study-in-southern-china-from-2013-to-2016
#11
Ling Zhang, Wenkuan Liu, Donglan Liu, Dehui Chen, Weiping Tan, Shuyan Qiu, Duo Xu, Xiao Li, Tiantian Liu, Rong Zhou
OBJECTIVES: Human metapneumovirus (HMPV) is one of the most important respiratory viral pathogens affecting infants and children worldwide. Our study describes the epidemiological and clinical characteristics of HMPV present in patients hospitalised with acute respiratory illness (ARI) in Guangzhou, Southern China. STUDY DESIGN: A cross-sectional study. SETTING: Two tertiary hospitals in Guangzhou. PARTICIPANTS AND METHODS: Throat swabs were collected over a 3-year period from 5133 paediatric patients (≤14 years) hospitalised with ARI...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29427710/pathophysiology-of-peste-des-petits-ruminants-in-sheep-dorper-kajli-and-goats-boer-beetal
#12
Ahrar Khan, M Kashif Saleemi, Farah Ali, Muhammad Abubakar, Riaz Hussain, Rao Zahid Abbas, Imtiaz Ahmad Khan
Peste des petits ruminants (PPR), an economically important viral transboundary disease of small ruminants is not only prevalent in Pakistan but also in other countries where people rely on agriculture and animal products. The present study was aimed at describing the pathology and antigen localization in natural PPR infections in local (Kajli sheep; Beetal goats) as well as imported small ruminant breeds (Dorper sheep; Australian Boer goat). Morbidity and mortality rates were significantly (P < 0.001) higher in indigenous Kajli sheep (75...
February 7, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29426476/larval-development-of-aelurostrongylus-abstrusus-in-experimentally-infected-rumina-decollata-snails
#13
Natalia M Cardillo, Mariano Ercole, Fernando Fariña, Mariana Pasqualetti, Yanina Loiza, Matías Pérez, Ayelén Bonboni, Mabel Ribicich
Aelurostrongylus abstrusus is a lungworm distributed worldwide that affects wild and domestic cats, causing bronchopneumonia of varying intensity. Snails serve as intermediate hosts. The aim of the present study was to assess the larval development of A. abstrusus in R. decollata snails and to investigate its potential as an intermediate host. For this purpose, first-stage larvae (L1) of A. abstrusus were obtained from the faeces of naturally infected cats. Doses of 500 L1/snail were given to 24 R. decollata snails, placed on the soil of the breeder chamber, and maintained under laboratory conditions...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29369727/respiratory-mites-orthohalarachne-diminuata-and-%C3%AE-hemolytic-streptococci-associated-bronchopneumonia-outbreak-in-south-american-fur-seal-pups-arctocephalus-australis
#14
Mauricio Seguel, Josefina Gutiérrez, Carlos Hernández, Felipe Montalva, Claudio Verdugo
  Although mites of the Orthohalarachne genus are common parasites of otariids, their role as agents of disease and in causing population-level mortality is unknown. In the austral summer of 2016, there was an increase in mortality among South American fur seal ( Arctocephalus australis) pups at Guafo Island, Northern Chilean Patagonia. Pups found dead or terminally ill had moderate to marked, multifocal, mucopurulent bronchopneumonia associated with large numbers of respiratory mites ( Orthohalarachne diminuata) and rare Gram-positive cocci...
January 25, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29245266/gastric-burkitt-lymphoma-a-case-report-and-literature-review
#15
Simona Gurzu, Tivadar Bara, Tivadar Jr Bara, Mihai Turcu, Ciprian Valentin Mardare, Ioan Jung
RATIONALE: Burkitt lymphoma (BL) is an endemic tumor in Africa but rare sporadic cases are diagnosed in Europe. PATIENT CONCERNS: A 60-year-old woman was hospitalized with fulminant hematemesis and a history of recurring melena. DIAGNOSES: The upper gastrointestinal endoscopy revealed a tumor of the antrum. INTERVENTIONS: Emergency gastrectomy was performed. OUTCOMES: Gross findings revealed an ulcerated tumor with elevated margins and several perigastric and extragastric lymph nodes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29227122/-hamartoma-of-mature-cardiac-myocytes-autopsy-case-report
#16
Šárka Hadravská, Magdaléna Dubová, Markéta Miesbauerová, Petr Mukenšnabl, Ondřej Daum, Alois Mádle, Karel Smetana
Hamartoma of mature cardiac myocytes (HMCM) is a rare benign pseudoneoplastic myocardial lesion. We describe a case of 39-year-old Bulgarian woman living in the Czech Republic, who died because of rupture of anterior communicating artery aneurysm, and severe bronchopneumonia. An incidental finding at the autopsy was a whitish unencapsulated and not sharply demarcated tumor of the left ventricle and adjacent area of interventricular septum, which protruded above the plane of section. Microscopically the tumor consisted of various different forms of disorganized hypertrophic mature cardiac myocytes without vacuolization of cytoplasm, focally in a "herringbone" pattern...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29212461/widespread-enlarged-perivascular-spaces-associated-with-dementia-and-focal-brain-dysfunction-case-report
#17
Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori, Takao Urabe
BACKGROUND: Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptomatic, some develop neurological dysfunctions; however, it remains unclear whether these are the consequence of widespread enlarged PVS. CASE PRESENTATION: A 64-year-old female patient developed consciousness disturbance, cognitive dysfunctions, fluent aphasia, agraphia, acalculia, and left-right disorientation after suffering from bronchopneumonia...
December 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29190684/respiratory-syncytial-and-influenza-viruses-in-children-under-2-years-old-with-severe-acute-respiratory-infection-sari-in-maputo-2015
#18
Mirela Pale, Afonso Nacoto, Almiro Tivane, Neuza Nguenha, Loira Machalele, Félix Gundane, Délcio Muteto, Josina Chilundo, Sandra Mavale, Cynthia Semá-Baltazar, Germano Pires, Orvalho Augusto, Tufária Mussá, Eduardo Gudo
INTRODUCTION: Although respiratory syncytial virus (RSV) and influenza virus (influenza) infections are one of the leading causes of Severe Acute Respiratory Infections (SARI) and death in young children worldwide, little is known about the burden of these pathogens in Mozambique. MATERIAL AND METHODS: From January 2015 to January 2016, nasopharyngeal swabs from 450 children, aged ≤2 years, who had been admitted to the Pediatric Department of the Maputo Central Hospital (HCM) in Mozambique, suffering with SARI were enrolled and tested for influenza and RSV using a real-time PCR assay...
2017: PloS One
https://www.readbyqxmd.com/read/29168366/normal-sweat-chloride-test-does-not-rule-out-cystic-fibrosis
#19
Abdurrahman Erdem Başaran, Nimet Karataş-Torun, İbrahim Cemal Maslak, Ayşen Bingöl, Özgül M Alper
Başaran AE, Karataş-Torun N, Maslak İC, Bingöl A, Alper ÖM. Normal sweat chloride test does not rule out cystic fibrosis. Turk J Pediatr 2017; 59: 68-70. A 5-month-old patient presented with complaints of fever and cough. He was hospitalized with the diagnosis of bronchopneumonia and pseudo-Bartter's syndrome. Patient was further investigated for diagnosis of cystic fibrosis. The chloride (Cl) level in sweat was determined within the normal range (25.1 mmol/L, 20.3 mmol/L). CFTR (Cystic Fibrosis Transmembrane Regulator gene; NM_000492...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29157308/characterization-of-the-upper-and-lower-respiratory-tract-microbiota-in-piedmontese-calves
#20
Isabella Nicola, Francesco Cerutti, Elena Grego, Iride Bertone, Paola Gianella, Antonio D'Angelo, Simone Peletto, Claudio Bellino
BACKGROUND: The microbiota of the bovine upper respiratory tract has been recently characterized, but no data for the lower respiratory tract are available. A major health problem in bovine medicine is infectious bronchopneumonia, the most common respiratory syndrome affecting cattle. With this study, we used 16S rRNA gene sequencing to characterize and compare the microbial community composition of the upper and lower respiratory tracts in calves. RESULTS: The microbiota of the upper (nasal swab [NS]) and the lower (trans-tracheal aspiration [TTA]) respiratory tracts of 19 post-weaned Piedmontese calves with (8/19) and without (11/19) clinical signs of respiratory disease, coming from six different farms, was characterized by 16S rRNA gene metabarcoding...
November 21, 2017: Microbiome
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