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https://www.readbyqxmd.com/read/27889820/ruxolitinib-in-clinical-practice-for-primary-and-secondary-myelofibrosis-an-analysis-of-safety-and-efficacy-of-gruppo-laziale-of-ph-negative-mpn
#1
Massimo Breccia, Alessandro Andriani, Marco Montanaro, Elisabetta Abruzzese, Francesco Buccisano, Michele Cedrone, Antonietta Centra, Nicoletta Villivà, Francesca Celesti, Malgorzata Monica Trawinska, Fulvio Massaro, Ambra Di Veroli, Barbara Anaclerico, Gioia Colafigli, Matteo Molica, Antonio Spadea, Luca Petriccione, Giuseppe Cimino, Roberto Latagliata
Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Cooperative Group for Ph negative myeloproliferative diseases.There were 45 males and 53 females; median age was 61.8 years (range 35.3-88). Forty-five patients were diagnosed as primary MF and 53 as secondary MF...
November 26, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27884843/traumatic-brain-injury-in-england-and-wales-prospective-audit-of-epidemiology-complications-and-standardised-mortality
#2
T Lawrence, A Helmy, O Bouamra, M Woodford, F Lecky, P J Hutchinson
OBJECTIVES: To provide a comprehensive assessment of the management of traumatic brain injury (TBI) relating to epidemiology, complications and standardised mortality across specialist units. DESIGN: The Trauma Audit and Research Network collects data prospectively on patients suffering trauma across England and Wales. We analysed all data collected on patients with TBI between April 2014 and June 2015. SETTING: Data were collected on patients presenting to emergency departments across 187 hospitals including 26 with specialist neurosurgical services, incorporating factors previously identified in the Ps14 multivariate logistic regression (Ps14(n)) model multivariate TBI outcome prediction model...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27805533/lung-biopsy-findings-of-patients-who-have-undergone-a-liver-and-kidney-transplant
#3
Gonca Özgün, Merih Tepeoğlu, Binnaz Handan Özdemir, Eda Yılmaz Akçay, Ebru Şebnem Ayva, Emine Ebru Deniz, Mehmet Haberal
OBJECTIVES: Our objective was to analyze the incidence of pulmonary disorders in solid-organ transplant recipients and report on outcomes in these patients. MATERIALS AND METHODS: Seventy liver and kidney transplant patients, who underwent lung biopsy because of pulmonary symptoms between January 2000 and December 2015, were enrolled in the study. We examined and evaluated histopathologic findings of these patients based on clinical data recorded in patients' files...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27780002/bordetella-pseudohinzii-as-a-confounding-organism-in-murine-models-of-pulmonary-disease
#4
Sarah E Clark, Jeanette E Purcell, Saad Sammani, Earl K Steffen, Marcus J Crim, Robert S Livingston, Cynthia Besch-Williford, Jeffrey D Fortman
A group studying acute lung injury observed an increased percentage of neutrophils in the bronchoalveolar lavage (BAL) fluid of mice. BAL was performed, and lung samples were collected sterilely from 5 C57BL/6 mice that had been bred inhouse. Pure colonies of bacteria, initially identified as Bordetella hinzii were cultured from 2 of the 5 mice which had the highest percentages of neutrophils (21% and 26%) in the BAL fluid. Subsequent sequencing of a portion of the ompA gene from this isolate demonstrated 100% homology with the published B...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27747296/the-spl-serine-proteases-modulate-staphylococcus-aureus-protein-production-and-virulence-in-a-rabbit-model-of-pneumonia
#5
Alexandra E Paharik, Wilmara Salgado-Pabon, David K Meyerholz, Mark J White, Patrick M Schlievert, Alexander R Horswill
The Spl proteases are a group of six serine proteases that are encoded on the νSaβ pathogenicity island and are unique to Staphylococcus aureus. Despite their interesting biochemistry, their biological substrates and functions in virulence have been difficult to elucidate. We found that an spl operon mutant of the community-associated methicillin-resistant S. aureus USA300 strain LAC induced localized lung damage in a rabbit model of pneumonia, characterized by bronchopneumonia observed histologically. Disease in the mutant-infected rabbits was restricted in distribution compared to that in wild-type USA300-infected rabbits...
September 2016: MSphere
https://www.readbyqxmd.com/read/27747295/influence-of-plasmid-type-on-the-replication-of-rhodococcus-equi-in-host-macrophages
#6
Jennifer M Willingham-Lane, Londa J Berghaus, Steeve Giguère, Mary K Hondalus
The soil-dwelling, saprophytic actinomycete Rhodococcus equi is a multihost, facultative intracellular pathogen of macrophages. When inhaled by susceptible foals, it causes severe bronchopneumonia. It is also a pathogen of pigs, which may develop submaxillary lymphadenitis upon exposure. R. equi isolates obtained from foals and pigs possess conjugative plasmids housing a pathogenicity island (PAI) containing a novel family of genes of unknown function called the virulence-associated protein or vap family. The PAI regions of the equine and swine plasmids differ in vap gene composition, with equine isolates possessing six vap genes, including the major virulence determinant vapA, while the PAIs of swine isolates house vapB and five other unique vap genes...
September 2016: MSphere
https://www.readbyqxmd.com/read/27738542/pyoderma-gangrenosum-a-rare-cause-of-cutaneous-ulceration-and-one-easily-misdiagnosed
#7
Wedad Abdelrahman, Maureen Y Walsh, Susannah E Hoey, Donal O'Kane
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis often misdiagnosed. It is uncommon in infants and children accounting for 4% of cases. A one-year-old male in paediatric ICU ventilated for bronchopneumonia was referred with ulcerated areas on his neck and axilla corresponding to sites of recent removal of central and arterial lines. Examination revealed areas of deep ulceration with violaceous undermined borders in keeping with PG. This was supported by a skin biopsy showing a neutrophilic infiltrate in the deeper dermis...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27738486/bacterial-pneumonia-caused-by-streptococcus-pyogenes-infection-a-case-report-and-review-of-the-literature
#8
Nobuhiro Akuzawa, Masahiko Kurabayashi
A 78-year-old Japanese man was admitted to our hospital because of fever lasting for 4 days. His white blood cell count and C-reactive protein level were elevated and computed tomography of the chest showed bronchopneumonia in the right upper lobe of the lung. Streptococcus pyogenes was detected from sputum and blood culture samples on admission and administration of ampicillin/sulbactam was effective. Although our patient's clinical course was good, S. pyogenes pneumonia commonly shows a high rate of fatality and septicemia, and may affect a previously healthy population...
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27733801/histopathological-and-immunohistochemical-approaches-for-the-diagnosis-of-pasteurellosis-in-swine-population-of-punjab
#9
Payal Bhat, Nittin Dev Singh, Geeta Devi Leishangthem, Amninder Kaur, Vishal Mahajan, Harmanjit Singh Banga, Rajinder Singh Brar
AIM: Infectious porcine bronchopneumonia, caused by Pasteurella multocida, is a widespread disease of major economic significance. Thus, the aim of the present study was to diagnose swine Pasteurellosis using gross, histopathological, and immunopathological approaches in the swine population of Punjab and to compare the efficacy of immunohistochemical (IHC) techniques with conventional diagnostic techniques. MATERIALS AND METHODS: A total of 71 adult swine lung samples showing gross pneumonic changes were collected along with the associated lymph nodes to carry out the study...
September 2016: Veterinary World
https://www.readbyqxmd.com/read/27594741/evaluation-of-drug-treatment-of-bronchopneumonia-at-the-pediatric-clinic-in-sarajevo
#10
Svjetlana Loga Zec, Kenan Selmanovic, Natasa Loga Andrijic, Azra Kadic, Lamija Zecevic, Lejla Zunic
INTRODUCTION: Bronchopneumonia is the most common clinical manifestation of pneumonia in pediatric population and leading infectious cause of mortality in children under 5 years. Evaluation of treatment involves diagnostic procedures, assessment of disease severity and treatment for disease with an emphasis on vulnerability of the population. AIM: To determine the most commonly used antibiotics at the Pediatric Clinic in Sarajevo and concomitant therapy in the treatment of bronchopneumonia...
June 2016: Medical Archives
https://www.readbyqxmd.com/read/27585963/urinary-kidney-injury-biomarkers-and-tobramycin-clearance-among-children-and-young-adults-with-cystic-fibrosis-a-population-pharmacokinetic-analysis
#11
Kevin J Downes, Min Dong, Tsuyoshi Fukuda, John P Clancy, Christopher Haffner, Michael R Bennett, Alexander A Vinks, Stuart L Goldstein
BACKGROUND: Tobramycin is frequently used for treatment of bronchopneumonia in patients with cystic fibrosis (CF). Variability in tobramycin clearance (CL) is high in this population with few reliable approaches to guide dosing. OBJECTIVES: We sought to evaluate the pharmacokinetics of once-daily intravenous tobramycin in patients with CF and test the influence of covariates on tobramycin CL, including serum creatinine (SCr) and urinary biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP) and kidney injury molecule-1 (KIM-1)...
September 1, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27578943/giant-solitary-ancient-schwannoma-of-the-pleura-masquerading-as-bronchopneumonia
#12
Shegu Gilbert, Devender Singh, Sivakumar Manjanaikkanpatti Kaliappan, Sangita Sharma Mehta
We report a 53-year-old female who presented with complaints of sudden onset breathlessness, cough with expectoration for 6 months, and a right lung base lesion in the chest X-ray, which was diagnosed and treated as bronchopneumonia by the family physician. High-resolution computed tomography of the chest was done which revealed a large heterogeneously enhancing mass in the right thoracic cavity. She underwent thoracotomy and was found to have a giant encapsulated and well-circumscribed mass arising from the pleura...
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27567271/pneumonia-due-to-chlamydia-pecorum-in-a-koala-phascolarctos-cinereus
#13
J T Mackie, A K Gillett, C Palmieri, T Feng, D P Higgins
Chlamydiosis is a common infectious disease of koalas (Phascolarctos cinereus), but Chlamydia spp. have not yet been demonstrated to cause pneumonia in these animals. A juvenile male koala died following an episode of respiratory disease. At necropsy examination, the lung tissue was consolidated. Microscopical lesions in the lung included pyogranulomatous bronchopneumonia, proliferation of bronchiolar and alveolar epithelium and interstitial fibrosis. Hyperplastic bronchiolar epithelial cells contained aggregates of small basophilic punctate organisms, which were confirmed as chlamydiae by transmission electron microscopy and immunohistochemistry...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27543322/spontaneous-and-dosing-route-related-lung-lesions-in-beagle-dogs-from-oral-gavage-and-inhalation-toxicity-studies-differentiation-from-compound-induced-lesions
#14
Sydney Mukaratirwa, Begonya Garcia, Kaori Isobe, Claudio Petterino, Alys Bradley
This study was conducted to characterize lung microscopic lesions in control beagle dogs from inhalation and oral gavage toxicity studies, to determine differences associated with the route of administration, and to discuss distinguishing features from compound-induced lung lesions. Samples from 138 control dogs from oral gavage studies and 124 control dogs from inhalation (vehicle control) studies were evaluated microscopically. There was no significant sex-related difference in the incidence of all lesions...
October 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27536550/occupationally-acquired-pasteurella-multocida-pneumonia-in-a-healthy-abattoir-worker
#15
Shyamala Pradeepan, Sandy Tun Min, Katy Lai
An otherwise healthy male abbatoir worker presented to his general practitioner with acute hypoxemia due to bronchopneumonia. His only occupational exposure was cleaning cow carcasses being prepared for consumption. Blood cultures were eventually positive for Pasteurella multocida. To our knowledge, this is the first reported case of Pasteurella multocida pneumonia in an abattoir worker, and illustrates the importance of considering this infection in patients with animal exposures.
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27531150/clinical-characteristics-and-computed-tomography-findings-of-pulmonary-toxoplasmosis-after-hematopoietic-stem-cell-transplantation
#16
Masahiko Sumi, Kazumi Norose, Kenji Hikosaka, Hiroko Kaiume, Wataru Takeda, Takehiko Kirihara, Taro Kurihara, Keijiro Sato, Toshimitsu Ueki, Yuki Hiroshima, Hiroshi Kuraishi, Masahide Watanabe, Hikaru Kobayashi
The prognosis of pulmonary toxoplasmosis, including disseminated toxoplasmosis involving the lungs, following hematopoietic stem cell transplantation (HSCT) is extremely poor due to the difficulties associated with early diagnosis and the rapidly progressive deterioration of multiorgan function. In our institution, we identified nine cases of toxoplasmosis, representing incidences of 2.2 and 19.6 % among all HSCT recipients and seropositive HSCT recipients, respectively. Of the patients with toxoplasmosis, six had pulmonary toxoplasmosis...
August 16, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27507806/spontaneous-lung-lesions-in-aging-laboratory-rabbits-oryctolagus-cuniculus
#17
T K Cooper, J W Griffith, Z C Chroneos, J M Izer, L B Willing, X Peng
Spontaneous age-related lesions of laboratory rabbits are not well documented in the contemporary scientific literature. A retrospective study of diagnostic necropsies of 36 rabbits >2 years of age found a number of common lung lesions. Fibromuscular intimal hyperplasia affected medium and to a lesser extent large pulmonary arteries and was present to a variable extent in all 36 rabbits >2 years of age. The lesions were characterized by fragmentation and/or reduplication of the internal elastic lamina (IEL), proliferation of smoothelin+/alpha-smooth muscle actin (α-SMA)+/vimentin- smooth muscle cells and fewer smoothelin-/α-SMA+/vimentin+ myofibroblasts, and intimal deposition of collagen without thrombosis, embolism, or evidence of pulmonary hypertension...
August 9, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27466784/septicemia-in-an-indian-rhesus-macaque-macaca-mulatta-associated-with-providencia-stuartii
#18
David X Liu, Peter J Didier, Gail Plauche, Bapi Pahar
Providencia stuartii (P. stuartii) is an opportunistic pathogen and major concern in urinary catheter-related infections in human medicine. Here we report P. stuartii-induced septicemia in an eighteen-year-old, female India-origin Rhesus macaque with multiple traumatic wounds. The animal had neutrophilic leukocytosis, necrosuppurative meningoencephalitis, hypophysitis and bronchopneumonia with vasculitis, thrombosis, and clusters of extracellular Gram-negative bacilli. P. stuartii was isolated from the lesions of the brain and lung and confirmed by PCR and sequencing...
July 28, 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/27412543/-distribution-characteristics-of-mycoplasma-pneumoniae-chlamydia-pneumoniae-and-legionella-pneumophila-in-hospitalized-children-with-acute-respiratory-tract-infection-an-analysis-of-13%C3%A2-198-cases
#19
Jia-Yi Liao, Tao Zhang
OBJECTIVE: To investigate the distribution characteristics of Mycoplasma pneumoniae (MP), Chlamydia pneumoniae (CP), and Legionella pneumophila (LP) in hospitalized children with acute respiratory tract infection (ARTI). METHODS: A total of 13 198 hospitalized children with ARTI were enrolled as study subjects. Whole blood and urine were collected. The passive agglutination was used to detect serum MP-IgM, ELISA was used to detect serum CP-IgM, and immunochromatography was performed to detect urinary LP antigen...
July 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27374658/cystic-fibrosis-a-report-of-33-pediatric-tunisian-cases
#20
Sonia Halioui-Louhaichi, Amel Ben Chehida, Rim Hassouna, Tayeb Massaoud, Marie Françoise Ben Dridi, Sihem Barsaoui, Azza Gharbi-Sammoud, Neji Tebib, Ahmed Maherzi
BACKGROUND: The frequency of cystic fibrosis is unknown in Tunisia, regarding the limited number of reported surveys and patients. AIM: to determine the clinical characteristics, outcome and genetic data of cystic fibrosis in Tunisian pediatric patients. METHODS: Cases of cystic fibrosis managed at pediatric departments of Tunis, during 15 years (1997-2012), were reviewed. RESULTS: 33 children (23 males and 10 females) were enrolled...
August 2015: La Tunisie Médicale
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