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antibiotics teratogenicity first trimester

Anna L Chien, Ji Qi, Barbara Rainer, Dana L Sachs, Yolanda R Helfrich
Acne vulgaris is a common disease of the pilosebaceous unit and affects adolescents and adults. Because high-quality guidelines regarding treatment of acne in pregnancy are scarce, management of this condition can be challenging. We describe the safety profile of common therapies and outline approaches based on available evidence. Topical azelaic acid or benzoyl peroxide can be recommended as baseline therapy. A combination of topical erythromycin or clindamycin with benzoyl peroxide is recommended for inflammatory acne...
March 2016: Journal of the American Board of Family Medicine: JABFM
Brady P Selig, James R Furr, Ryan W Huey, Colin Moran, Vinod N Alluri, Gregory R Medders, Christina D Mumm, H Gene Hallford, John J Mulvihill
BACKGROUND: Cancer is the second leading cause of death among women of reproductive age. Although the coincidence of pregnancy and cancer is rare and treatment may sometimes be safely delayed, the use of chemotherapeutic agents in pregnancy is sometimes unavoidable or inadvertent. METHODS: We review the literature for the use of antineoplastic agents in single-agent and combination therapy from 1951 through June 2012. We also summarize the evidence relating to teratogenicity of disorder-specific combination chemotherapy treatments for those malignancies frequently encountered in women of childbearing age...
August 2012: Birth Defects Research. Part A, Clinical and Molecular Teratology
Benjamin Bar-Oz, Corinna Weber-Schoendorfer, Maya Berlin, Maurizio Clementi, Elena Di Gianantonio, Loes de Vries, Marco De Santis, Paul Merlob, Bracha Stahl, Giorgio Eleftheriou, Eva Maňáková, Lucie Hubičková-Heringová, Ilan Youngster, Matitiahu Berkovitch
BACKGROUND: Macrolides are a group of commonly prescribed antibiotics. There is some doubt surrounding the use of the newer macrolides in pregnancy. OBJECTIVE: The present study aimed to compare outcomes of pregnancies exposed to the new macrolides clarithromycin, azithromycin and roxithromycin with non-teratogenic preparations. METHODS: In this prospective, multinational, multicentre, controlled, observational study, information was obtained either from pregnant women or their healthcare professionals who contacted their local teratogen information services in Italy, Israel, the Czech Republic, the Netherlands and Germany seeking information after exposure to macrolides...
July 1, 2012: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
M Erić, M Leppée, A Sabo, J Culig
BACKGROUND AND OBJECTIVES: During pregnancy, a number of changes occur in women's body, and some medications are safe and some are not. The aim of our study was to establish the possible correlation between use of beta-lactam antibiotics in pregnancy and occurrence of congenital malformations. MATERIAL AND METHODS: The study included 893 pregnant women from Zagreb and 6099 pregnant women from Novi Sad. 527 pregnant women used beta-lactams. First part of the study (one month study) was performed at four maternity hospitals in Zagreb, Croatia...
January 2012: European Review for Medical and Pharmacological Sciences
Tatiana Diehl Zen, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen, Patrícia Trevisan, Alessandra Pawelec da Silva, Cláudia Pires Ricachinevsky, Giorgio Adriano Paskulin
BACKGROUND: Congenital heart disease (CHD) is a serious threat to public health. Despite this, its etiology is poorly understood and few cardiac teratogens have been defined. The aim of the present study was to identify gestational and family risk factors for CHD in a sample of patients from a pediatric hospital in southern Brazil. METHODS: A prospective and consecutive sample from subjects with or without CHD, hospitalized at a pediatric intensive care unit, was enrolled...
August 2011: Pediatrics International: Official Journal of the Japan Pediatric Society
Fatma Bahar Cebesoy, Ozcan Balat, Ahmet Mete
Herein, we report the unique case of Brucella-related lumbar vertebral fracture in a first trimester pregnant woman. The unique effective treatment protocol for the infection is prolonged combined antibiotics and immobilization with follow-up, even in the presence of vertebral fracture related to spinal disease. With the accurate choice of anthiobitics (suitable, non-teratogenic and non-toxic for the fetus) therapeutic abortion is not indicated.
August 2009: Archives of Gynecology and Obstetrics
Benjamin Bar-Oz, Orna Diav-Citrin, Svetlana Shechtman, Rotem Tellem, Judith Arnon, Igor Francetic, Matitiahu Berkovitch, Asher Ornoy
OBJECTIVES: To determine whether the use of the new macrolides (azithromycin, clarithromycin, roxithromycin) during the first trimester of pregnancy is associated with an increased risk of major malformations. STUDY DESIGN: In a prospective multi-center study, pregnancy outcome was compared between pregnant women exposed to one of the new macrolides during the first trimester of pregnancy and two comparison groups one exposed to other antibiotics and the other to other non-teratogenic medications...
November 2008: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Petros V Vlastarakos, Thomas P Nikolopoulos, Leonidas Manolopoulos, Eleftherios Ferekidis, George Kreatsas
In everyday practise, more than 80% of pregnant women receive one at least medication, often for ENT causes. The aim of the present paper is to review the literature on safety and administration of medical treatment for ear diseases, in pregnant women. The literature review includes Medline and database sources. Electronic links, related books and written guidelines were also included. The study selection was as follows: controlled clinical trials, prospective trials, case-control studies, laboratory studies, clinical reviews, systematic reviews, metanalyses, and case reports...
February 2008: European Archives of Oto-rhino-laryngology
Hideyuki Iwayama, Haruki Hosono, Hikaru Yamamoto, Makoto Oshiro, Norishi Ueda
BACKGROUND: Aplasia cutis congenita (ACC) is a condition in which localized or widespread areas of skin are absent at birth. Defective lesions show complete absence of all layers of skin, occasionally extending to skull or dura. ACC is etiologically heterogeneous; many different etiologies including teratogens have been documented. CASE: We describe the first reported case of a monozygotic twin with ACC after exposure to methimazole in utero. The female patient was born at 36 weeks gestation as the first child of monozygotic twins...
October 2007: Birth Defects Research. Part A, Clinical and Molecular Teratology
Moumita Sarkar, Cindy Woodland, Gideon Koren, Adrienne R N Einarson
BACKGROUND: Azithromycin is an azalide antibiotic with an extensive range of indications and has become a common treatment option due to its convenient dosing regimen and therapeutic advantages. Human studies addressing gestational use of azithromycin have primarily focused on antibiotic efficacy rather than fetal safety. Our primary objective was to evaluate the possibility of teratogenic risk following gestational exposure to azithromycin. METHODS: There were 3 groups of pregnant women enrolled in our study: 1) women who took azithromycin, 2) women exposed to non-teratogenic antibiotics for similar indications, and 3) women exposed to non-teratogenic agents...
May 30, 2006: BMC Pregnancy and Childbirth
Giorgio Adriano Paskulin, Paulo Ricardo Gazzola Zen, Louise Lapagesse de Camargo Pinto, Rafael Rosa, Carla Graziadio
BACKGROUND: The concomitant occurrence of breast cancer and pregnancy is relatively uncommon. We report the case of a patient with syndactyly, cleft hands, and absence of distal finger phalanges associated with maternal exposure to chemotherapeutic agents during the first trimester of pregnancy. These associations have not been previously described. CASE: The patient was born by normal delivery after 38 weeks of pregnancy. His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy...
September 2005: Birth Defects Research. Part A, Clinical and Molecular Teratology
F Yaris, M Kadioglu, M Kesim, M Unsal, E Yaris, C Ulku, N I Kalyoncu
AIM: Many pregnant women are exposed to antibiotics for urinary tract infections during pregnancy. Our aim is to bring attention to antibiotherapy in unplanned pregnancies. METHOD: Among the 511 cases followed by our 'Toxicology Information and Follow-up Service' for drug exposure during pregnancy, 101 cases, unaware of their pregnancy, had been prescribed antibiotics and urinary antiseptic drugs in the first trimester of their unplanned pregnancies. The data on the outcome of these pregnancies and the babies were evaluated in this study...
September 2004: European Journal of Contraception & Reproductive Health Care
C R Drinkard, D Shatin, J Clouse
PURPOSE: This retrospective surveillance study used linked administrative claims data and medical records to determine the rate and types of birth malformations in infants born to women exposed to the antibiotic, clarithromycin (Biaxin), during the first trimester of pregnancy. METHODS: Pharmacy and hospital claims from eight geographically diverse health plans were used to identify women who had a delivery claim within 270 days of a clarithromycin prescription over a 5-year period (1991-1995)...
December 2000: Pharmacoepidemiology and Drug Safety
B Christensen
Bacteriuria in pregnancy, with or without clinical symptoms, is frequent. If left untreated, it can in 20-30% of cases lead to acute pyelonephritis, which is a serious threat to the mother and fetus, increasing the risk of preterm labour and low birthweight infants. This paper is a review of the literature concerning antibacterial treatment of bacteriuria in pregnancy. It is crucial to ensure that drugs to be used in pregnancy are safe and effective. Established first-line drugs such as ampicillin (pivampicillin) and amoxycillin, and other commonly used treatments such as trimethoprim-sulphamethoxazole, are associated with a high degree of resistance in Escherichia coli, the most common pathogen in the urinary tract...
September 2000: Journal of Antimicrobial Chemotherapy
Bacteriuria in pregnancy, with or without clinical symptoms, is frequent. If left untreated, it can in 20-30% of cases lead to acute pyelonephritis, which is a serious threat to the mother and fetus, increasing the risk of preterm labour and low birthweight infants. This paper is a review of the literature concerning antibacterial treatment of bacteriuria in pregnancy. It is crucial to ensure that drugs to be used in pregnancy are safe and effective. Established first-line drugs such as ampicillin (pivampicillin) and amoxycillin, and other commonly used treatments such as trimethoprim-sulphamethoxazole, are associated with a high degree of resistance in Escherichia coli, the most common pathogen in the urinary tract...
August 2000: Journal of Antimicrobial Chemotherapy
M Berkovitch, I Segal-Socher, R Greenberg, M Bulkowshtein, J Arnon, P Merlob, A Or-Noy
AIMS: There are no published studies on the safety of cefuroxime use during pregnancy. We therefore investigated prospectively the possible teratogenic effect of intrauterine exposure to cefuroxime. METHODS: One hundred and six women who received cefuroxime during the first trimester of pregnancy were recruited from three teratogen information centres in Israel. Exposed women were paired for age, smoking habits and alcohol consumption with references being exposed to nonteratogenic antibiotics administered for the same indications...
August 2000: British Journal of Clinical Pharmacology
B Dautzenberg, J Grosset
Tuberculosis is neither more frequent, nor more serious in pregnant than non-pregnant women. The risks for the child are threefold: a doubling in the mortality level on account of the illness in the mother if she is not treated; a risk of toxicity linked to the anti-tuberculous drugs and a risk of tuberculous infection at birth. Isoniazid (INH) and ethambutol have a weak toxicity. These two antibiotics can be prescribed during pregnancy (after confirming the absence of Vitamin B6 deficiency in the mother). Rifampicin is teratogenic in high doses in animals, but epidemiological studies do not reveal any notable risk in man...
1988: Revue des Maladies Respiratoires
M M Werler, A A Mitchell, S Shapiro
In a case-control surveillance program, first trimester medication use was studied in relation to gastroschisis. There were 76 cases of gastroschisis which were compared with 2,142 controls with other major malformations. For pseudoephedrine use, we found a significantly elevated relative risk of 3.2 (95% confidence interval, 1.3-7.7), with adjustment for confounding. Multivariate relative risks for analgesic/antipyretics and another decongestant were as follows: salicylates, 1.6 (0.9-2.7); acetaminophen, 1...
April 1992: Teratology
S Kullander, B Källén
The results are presented of a prospective study on drug use during pregnancy involving antibiotics, analgesic drugs and iron and vitamin preparations. The study was conducted in Malmö between 1963 and 1965. No unfavourable effect of the use of antibiotics, mainly penicillin and sulphonamides, could be demonstrated. Among 15 women who had an infant with hypospadias, three had used penicillin during the first trimester, but this may well be coincidental. Analgesic drug use shows a variability which resembles that previously described for psychopharmaca...
1976: Acta Obstetricia et Gynecologica Scandinavica
G Schaison, C Jacquillat, G Auclerc, M Weil
The risks of embryonic, fetal, gondal damage of cancer chemotherapy are reviewed. Contrasting with the numerous malformations seen in laboratory animals, the teratogenic risk is low in man. Methotrexate is really dangerous during the first trimester of pregnancy. In malignant haematological diseases and solid tumours, the prognosis of the disease is the essential target but the use of immuno-suppressive drugs in non-malignant diseases is hazardous before 40 years of age. All the investigations show that alkylating agents injure the gonads...
1979: Bulletin du Cancer
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