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antibiotics teratogenicity

M Štefan, J Vojtěch
OBJECTIVE: This article reviews up-to-date data on antibiotic therapy in pregnancy. DESIGN: Review article. SETTING: Department of Infectious Diseases, Military University Hospital Prague; Institute for the Care of Mother and Child, Prague. MATERIAL AND METHODS: Relevant literary sources have been considered, including articles in English indexed in Pubmed, monographies in English and articles in Czech. CONCLUSIONS: Antibiotic therapy in pregnancy must be rational...
December 0: Ceská Gynekologie
Hassan A Hemeg
Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics...
2017: International Journal of Nanomedicine
Davide Marco Croci, Martina Dalolio, Stefan Schaeren, Morten G Wasner, Luigi Mariani, Gregory F Jost
A 54-year-old male presented with a sudden burning sensation during urination and left flank pain. Apart from having congenital facial palsy and malformation of the inner right ear that was linked to thalidomide embryopathy, the patient has always been in good health. Urine examination showed the presence of a urinary tract infection. An abdominal ultrasound revealed a large cyst in the lower abdomen, which on MRI corresponded to a large anterior sacral meningocele (ASM) with sacral agenesis at S1/S2. After antibiotic treatment and the spontaneous passage of a kidney stone, the symptoms resolved...
October 9, 2017: Birth Defects Research
Rafaela J da Silva, Angelica O Gomes, Priscila S Franco, Ariane S Pereira, Iliana C B Milian, Mayara Ribeiro, Paolo Fiorenzani, Maria C Dos Santos, José R Mineo, Neide M da Silva, Eloisa A V Ferro, Bellisa de Freitas Barbosa
Classical treatment for congenital toxoplasmosis is based on combination of sulfadiazine and pyrimethamine plus folinic acid. Due to teratogenic effects and bone marrow suppression caused by pyrimethamine, the establishment of new therapeutic strategies is indispensable to minimize the side effects and improve the control of infection. Previous studies demonstrated that enrofloxacin and toltrazuril reduced the incidence of Neospora caninum and Toxoplasma gondii infection. The aim of the present study was to evaluate the efficacy of enrofloxacin and toltrazuril in the control of T...
2017: Frontiers in Cellular and Infection Microbiology
John F Trujillo, Steven M Hollenberg
Patients undergoing cardiac valve replacement may receive mechanical or bioprosthetic valves. Mechanical valves require lifelong anticoagulation but are durable and the need for a second surgery is up to eightfold times less than with bioprosthetic valves. Bioprosthetic valves do not require lifelong anticoagulation and thus are associated with fewer bleeding complications but they are less durable and associated with higher morbidity and mortality rates, particularly in younger patients. Anticoagulation with mechanical valves is achieved using warfarin; use of direct-acting oral anticoagulants is not indicated...
June 2017: FP Essentials
Necip Girit, Ibrahim Tugrul, Buket Demirci, Ozlem Bozkurt, Turhan Dost, Mustafa Birincioglu, H Alper Tanriverdi
AIM: This short communication aims to evaluate the relation in between drug exposure time and early pregnancy regarding gestational weeks. METHODS: The study covers the referrals made to the Department of Pharmacology for a teratogenic consultation in a 3-year period. From the recordings of pregnant women, the last menstrual period and the starting date of medication were used to determine the time of prescription with regard to gestational weeks. RESULTS: In all of the three years, potentially teratogenic medication was prescribed more frequently in the 3rd, 4th and 5th gestational weeks (in between 15-35 days of pregnancy)...
February 15, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
Christos C Zouboulis, Clio Dessinioti, Fragkiski Tsatsou, Harald P M Gollnick
Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue...
July 2017: Expert Opinion on Investigational Drugs
Vinay Kumar, Neha Sharma, S S Maitra
Dibutyl phthalate is (DBP) the top priority toxicant responsible for carcinogenicity, teratogenicity and endocrine disruption. This study demonstrates the DBP degradation capability of the two newly isolated bacteria from municipal solid waste leachate samples. The isolated bacteria were designated as Pseudomonas sp. V21b and Comamonas sp. 51F after scanning electron microscopy, transmission electron microscopy, Gram-staining, antibiotic sensitivity tests, biochemical characterization, 16S-rRNA gene identification and phylogenetic studies...
September 2017: Biotechnology Reports
A Ouanounou, D A Haas
Pregnancy is accompanied by various physiological and physical changes, including those found in the cardiovascular, respiratory, gastrointestinal, renal and haematological systems. These alterations in the pregnant patient may potentially affect drug pharmacokinetics. Also, pharmacotherapy presents a unique matter due to the potential teratogenic effects of certain drugs. Although medications prescribed by dentists are generally safe during pregnancy, some modifications may be needed. In this article we will discuss the changes in the physiology during pregnancy and its impact on drug therapy...
April 22, 2016: British Dental Journal
Jeffrey A Keelan, Matthew S Payne, Matthew W Kemp, Demelza J Ireland, John P Newnham
Intrauterine infection-inflammation is a major cause of early preterm birth and subsequent neonatal mortality and acute or long-term morbidity. Antibiotics can be administered in pregnancy to prevent preterm birth either prophylactically to women at high risk for preterm delivery, or to women with diagnosed intrauterine infection, prelabor rupture of membranes, or in suspected preterm labor. The therapeutic goals of each of these scenarios are different, with different pharmacological considerations, although effective antimicrobial therapy is an essential requirement...
2016: Frontiers in Immunology
Alexa Dinant, Ramiz A Boulos
BACKGROUND: Acne is a prominent skin condition affecting >80% of teenagers and young adults and ~650 million people globally. Isotretinoin, a vitamin A derivative, is currently the standard of care for treatment. However, it has a well-established teratogenic activity, a reason for the development of novel and low-risk treatment options for acne. OBJECTIVE: To investigate the effectiveness of Zolav(®), (a p-carboethoxy-tristyrylbenzene derivative) [corrected] a novel antibiotic as a treatment for acne vulgaris...
2016: Drug Design, Development and Therapy
Anna L Chien, Ji Qi, Barbara Rainer, Dana L Sachs, Yolanda R Helfrich
Acne vulgaris is a common disease of the pilosebaceous unit and affects adolescents and adults. Because high-quality guidelines regarding treatment of acne in pregnancy are scarce, management of this condition can be challenging. We describe the safety profile of common therapies and outline approaches based on available evidence. Topical azelaic acid or benzoyl peroxide can be recommended as baseline therapy. A combination of topical erythromycin or clindamycin with benzoyl peroxide is recommended for inflammatory acne...
March 2016: Journal of the American Board of Family Medicine: JABFM
(no author information available yet)
When bacterial pneumonia contracted in hospital (nosocomial pneumonia) is thought to be due to a methicillin-resistant strain of S. aureus, the most commonly used antibiotics are vancomycin and teicoplanin (glycopeptides) or linezolid (an oxazolidinone). Telavancin, a glycopeptide derived from vancomycin, is active in vitro against methicillin-resistant S. aureus. It has been authorised in the European Union for second-line treatment of patients with nosocomial pneumonia caused by methicillin-resistant S. aureus...
November 2015: Prescrire International
Kenneth P Klinker, Samuel J Borgert
PURPOSE: The purpose of this comparative review is to provide clinical information on the semisynthetic lipoglycopeptides (telavancin, oritavancin, and dalbavancin) for the management of gram-positive infections. METHODS: A PubMed search was conducted using the following terms: telavancin, dalbavancin, and oritavancin. Clinical trials evaluating pharmacokinetic properties, pharmacodynamic properties, clinical efficacy, and safety profiles were included in the review...
December 1, 2015: Clinical Therapeutics
Svetla Gadzhanova, Elizabeth Roughead
BACKGROUND: This study aimed to examine current utilisation of prescribed medicines amongst Australian women of child-bearing age, with a particular focus on the extent of use of medicines in Category D and X risk groups, which are moderate and high risk teratogens, respectively. The use of those medicines may pose risk of birth defects in pregnant women. METHODS: A retrospective cross-sectional study was undertaken involving all women of child-bearing age (15 to 44 years) who were dispensed medicines in 2013 using the 10% random sample of dispensing data from the Australian Government Department of Human Services...
2015: BMC Pharmacology & Toxicology
K Isa, K Oka, N Beauchamp, M Sato, K Wada, K Ohtani, S Nakanishi, E McCartney, M Tanaka, T Shimizu, S Kamiya, C Kruger, M Takahashi
Probiotics are live microorganisms ingested for the purpose of conferring a health benefit on the host. Development of new probiotics includes the need for safety evaluations that should consider factors such as pathogenicity, infectivity, virulence factors, toxicity, and metabolic activity. Clostridium butyricum MIYAIRI 588(®) (CBM 588(®)), an anaerobic spore-forming bacterium, has been developed as a probiotic for use by humans and food animals. Safety studies of this probiotic strain have been conducted and include assessment of antimicrobial sensitivity, documentation of the lack of Clostridium toxin genes, and evaluation of CBM 588(®) on reproductive and developmental toxicity in a rodent model...
August 2016: Human & Experimental Toxicology
Md Torequl Islam, Marcus Vinícius Oliveira Barros de Alencar, Katia da Conceição Machado, Keylla da Conceição Machado, Ana Amélia de Carvalho Melo-Cavalcante, Damiao Pergentino de Sousa, Rivelilson Mendes de Freitas
This study aims to review phytol (PYT), through published articles, periodicals, magazines and patents, which were retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and INPI databases. Among the 149 articles and 62 patents, 27.52% articles and 87.09% patients were found on the searched topic, PYT and its sources and synthesis and metabolism; then followed by 15.44% and 14.77% articles on PYT in cytotoxicity/cancer/mutagenicity/teratogenicity and PYT in neurological diseases, respectively. In the pharma-medico viewpoint, PYT and its derivatives have been evident to have antimicrobial, cytotoxic, antitumorous, antimutagenic, anti-teratogenic, antibiotic-chemotherapeutic, antidiabetic, lipid lowering, antispasmodic, anticonvulsant, antinociceptive, antioxidant, anti-inflammatory, anxiolytic, antidepressant, immunoadjuvancy, hair growth facilitator, hair fall defense and antidandruff activities...
October 5, 2015: Chemico-biological Interactions
Odile Sheehy, Fabiano Santos, Ema Ferreira, Anick Berard
OBJECTIVE: To review the available evidence concerning the relationship between the exposure to metronidazole during pregnancy and the risk of preterm delivery and birth defects. METHODS: Studies investigating the association between gestational use of oral metronidazole on human subjects and the risk of preterm birth or/and birth defects were systematically retrieved from MEDLINE and EMBASE databases. We selected studies published in English or French between 1964 and 2012...
2015: Current Drug Safety
Monika K Goyal, Adam L Hersh, Gia Badolato, Xianqun Luan, Maria Trent, Theoklis Zaoutis, James M Chamberlain
OBJECTIVES: The objectives were to estimate the frequency of pregnancy testing in emergency department (ED) visits by reproductive-aged women administered or prescribed teratogenic medications (Food and Drug Administration categories D or X) and to determine factors associated with nonreceipt of a pregnancy test. METHODS: This was a retrospective cross-sectional study using 2005 through 2009 National Hospital Ambulatory Medical Care Survey data of ED visits by females ages 14 to 40 years...
February 2015: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Enav Yefet, Raed Salim, Bibiana Chazan, Hiba Akel, Shabtai Romano, Zohar Nachum
Quinolones and fluoroquinolones are highly efficient antibiotics. However, concerns regarding possible harmful effects have limited their use during pregnancy. Nevertheless, accumulating clinical data suggest that they may be safe during pregnancy. This review aimed to explore the mechanisms of action of the quinolones and fluoroquinolones, which set the stage for concerns regarding possible teratogenic and mutagenic effects; to clarify the clinical dilemmas that brought forth the necessity in reevaluating the use of those medications during pregnancy; and to review the accumulated data regarding their safety during pregnancy in animal models and humans...
November 2014: Obstetrical & Gynecological Survey
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