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Bupivacaine liposomal

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https://www.readbyqxmd.com/read/29163750/long-acting-liposomal-bupivacaine-for-percutaneous-sympathetic-stellate-ganglion-blockade-a-technical-note
#1
Adnan I Qureshi, Muhammad A Waqas, Vikram Jadhav, Muhammad A Saleem, Jeff Campbell, Shawn S Wallery
Introduction: We describe the use of long acting liposomal bupivacaine for percutaneous stellate ganglion blockade to treat severe headaches following internal carotid artery dissection. Methods: A 43-year old woman developed right-sided refractory headache after right internal carotid artery dissection. Patient underwent percutaneous stellate ganglion block using bupivacaine hydrochloride (0.25%-20 ml) in the past with short acting relief. Liposomal bupivacaine (EXPAREL) 13...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29126979/ropivacaine-and-bupivacaine-prevent-increased-pain-sensitivity-without-altering-neuroimmune-activation-following-repeated-social-defeat-stress
#2
Caroline M Sawicki, January K Kim, Michael D Weber, Brant L Jarrett, Jonathan P Godbout, John F Sheridan, Michelle Humeidan
OBJECTIVE: Mounting evidence indicates that stress influences the experience of pain. Exposure to psychosocial stress disrupts bi-directional communication pathways between the central nervous system and peripheral immune system, and can exacerbate the frequency and severity of pain experienced by stressed subjects. Repeated social defeat (RSD) is a murine model of psychosocial stress that recapitulates the immune and behavioral responses to stress observed in humans, including activation of stress-reactive neurocircuitry and increased pro-inflammatory cytokine production...
November 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29108087/bupivacaine-versus-liposomal-bupivacaine-for-pain-control
#3
Siavash Beiranvand, Mahmoud Reza Moradkhani
Local infiltrations and regional blocks have been some of the effective ways employed to manage and control post-operative pain. One of the limitations of administration of local anesthesia drugs in post-operative conditions is its inability to act for a longer period of time. Multi-vesicular liposomes made up of bupivacaine have been progressively used for their increased duration of action. Compared to bupivacaine HCL, local infiltration of liposomal bupivacaine have shown to have a significantly increase the duration and delay in peak plasma concentration...
November 6, 2017: Drug Research
https://www.readbyqxmd.com/read/29095194/liposomal-bupivacaine-may-benefit-select-reduction-mammaplasty-patients
#4
Shana S Kalaria, Stefanos Boukovalas, Pablo L Padilla, Jacquelynn P Tran, Ramon T Li, Linda G Phillips
BACKGROUND: Postoperative pain control can be challenging in reduction mammaplasty patients. This study compares perioperative liposomal bupivacaine (Exparel; Pacira Pharmaceuticals, Inc, San Diego, Calif) with standard local anesthetics to determine if liposomal bupivacaine decreases opioid and antiemetic use, impacting length of stay and complication rates, thus improving patient outcomes. METHODS: A retrospective review of 170 reduction mammaplasty patients was performed...
October 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29067198/an-extended-release-local-anaesthetic-potential-for-future-use-in-veterinary-surgical-patients
#5
REVIEW
B Duncan X Lascelles, Kristin Kirkby Shaw
One of the most effective means of preventing the transduction and transmission of acute and perioperative pain is through the use of local anaesthetics. However, local anaesthetics currently available have a relatively short duration of action. Although there are several tools available to treat perioperative pain in companion animals, overall, there is an unmet need for products that can be administered in the clinic, and provide pain relief for the crucial first few days following surgery in the home environment...
November 2016: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29065741/intra-incisional-liposomal-bupivacaine-and-its-impact-on-post-cesarean-analgesia-a-retrospective-study
#6
Pavan Parikh, Imran Sunesara, Sukhpreet Singh Multani, Brandy Patterson, Elizabeth Lutz, James N Martin
PURPOSE: The efficacy of long acting intra-incisional bupivacaine in reducing postoperative opioid use amongst women who have undergone a cesarean is currently unknown. MATERIALS AND METHODS: This was a retrospective case-control study with a 1:1 allocation. We identified 40 patients in each group, for a total of 80. The treatment group was administered 266 mg of liposomal bupivacaine after completion of the cesarean and was compared to historical controls. Data regarding anesthesia administered, opioid consumption, nonsteroidal anti-inflammatory use, acetaminophen use, type of cesarean, reason for cesarean and length of postoperative stay were recorded...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29062649/multimodal-analgesia-in-breast-surgical-procedures-technical-and-pharmacological-considerations-for-liposomal-bupivacaine-use
#7
Anoushka M Afonso, Martin I Newman, Neil Seeley, Jacob Hutchins, Kevin L Smith, Gabriel Mena, Jesse C Selber, Michel H Saint-Cyr, Jeffrey C Gadsden
Enhanced recovery after surgery is a multidisciplinary perioperative clinical pathway that uses evidence-based interventions to improve the patient experience as well as increase satisfaction, reduce costs, mitigate the surgical stress response, accelerate functional recovery, and decrease perioperative complications. One of the most important elements of enhanced recovery pathways is multimodal pain management. Herein, aspects relating to multimodal analgesia following breast surgical procedures are discussed with the understanding that treatment decisions should be individualized and guided by sound clinical judgment...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29061282/analgesic-efficacy-of-laparoscopic-guided-transverse-abdominis-plane-block-using-liposomal-bupivacaine-in-bariatric-surgery
#8
Avinash Bhakta, Owen Glotzer, Ashar Ata, Marcel Tafen, Steven C Stain, Paul T Singh
BACKGROUND: Postoperative pain management is a major contributor to recovery and discharge in bariatric surgery. Local anesthetic agents are of particular interest: they're non-sedating and may reduce postoperative pain and hospital length of stay (LOS). DESIGN: Researchers queried the Bariatric Surgery Service Database for patients undergoing laparoscopic weight loss surgery from January 2012-December 2014. Patients were divided between those who did and did not receive liposomal bupivacaine intra-operatively...
September 20, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29055733/qx-oh-levobupivacaine-fixed-dose-combination-to-provide-a-long-acting-postoperative-pain-of-knee-surgery-in-rodents
#9
WenLing Zhao, Jun Yang, YuJun Zhang, Jin Liu, WenSheng Zhang
Although total knee arthroplasty (TKA) is a commonly performed procedure, anesthetic efficacy in post-surgical pain remains an issue. Exparel (45mM liposome bupivacaine), a relatively long-acting local anesthetic, has shown efficacy in blocking peripheral nerve or periarticular infiltration to achieve better post-TKA analgesia. In the present work, we tested whether a fixed-dose combination of QX-OH (35mM) and levobupivacaine (10mM) (QX-OH/LB) could confer longer-lasting pain relief and reduce periarticular tissue toxicity compared to liposome bupivacaine (45mM) after TKA operation...
October 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29033152/intraoperative-infiltration-of-liposomal-bupivacaine-vs-bupivacaine-hydrochloride-for-pain-management-in-primary-total-hip-arthroplasty-a-prospective-randomized-trial
#10
Itay Perets, John P Walsh, Brian H Mu, Leslie C Yuen, Lyall Ashberg, Muriel R Battaglia, Benjamin G Domb
BACKGROUND: Pain management after total hip arthroplasty is well studied. Nevertheless, there is no consensus regarding the "cocktail" to use in periarticular infiltration (PAI). Liposomal bupivacaine (LB) is a slow release local anesthetic that can be infiltrated during surgery. In this study, we compared LB to bupivacaine hydrochloride (HCL). METHODS: Between September 2014 and March 2016, 181 patients were screened for this prospective randomized trial. A total of 107 patients were enrolled and studied...
September 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29016551/pectoral-fascial-pecs-i-and-ii-blocks-as-rescue-analgesia-in-a-patient-undergoing-minimally-invasive-cardiac-surgery
#11
Suraj Yalamuri, Rebecca Y Klinger, W Michael Bullock, Donald D Glower, Brandi A Bottiger, Jeffrey C Gadsden
INTRODUCTION: Patients undergoing minimally invasive cardiac surgery have the potential for significant pain from the thoracotomy site. We report the successful use of pectoral nerve block types I and II (Pecs I and II) as rescue analgesia in a patient undergoing minimally invasive mitral valve repair. CASE REPORT: In this case, a 78-year-old man, with no history of chronic pain, underwent mitral valve repair via right anterior thoracotomy for severe mitral regurgitation...
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28992420/improved-chondrotoxic-profile-of-liposomal-bupivacaine-compared-with-standard-bupivacaine-after-intra-articular-infiltration-in-a-porcine-model
#12
K Aaron Shaw, Colleen Moreland, Jeremy Jacobs, Justin M Hire, Richard Topolski, Nathan Hoyt, Stephen A Parada, Craig D Cameron
BACKGROUND: Increasingly, liposomal bupivacaine is being used with multimodal pain management strategies. In vitro investigations have shown decreased chondrotoxicity profiles for liposomal bupivacaine; however, there is no evidence regarding its in vivo effects. Hypothesis/Purpose: This study sought to investigate the in vivo chondrotoxicity of liposomal bupivacaine, hypothesizing that there would be increased chondrocyte viability after exposure to liposomal bupivacaine when compared with standard bupivacaine...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28982145/encapsulation-of-ropivacaine-in-a-combined-donor-acceptor-ionic-gradient-liposomal-system-promotes-extended-anesthesia-time
#13
Camila Morais Gonçalves da Silva, Michelle Franz-Montan, Cíntia Elisabeth Gomez Limia, Lígia Nunes de Morais Ribeiro, Mário Antônio Braga, Viviane Aparecida Guilherme, Camila Batista da Silva, Bruna Renata Casadei, Cíntia Maria Saia Cereda, Eneida de Paula
Ropivacaine is a local anesthetic with similar potency but lower systemic toxicity than bupivacaine, the most commonly used spinal anesthetic. The present study concerns the development of a combined drug delivery system for ropivacaine, comprised of two types of liposomes: donor multivesicular vesicles containing 250 mM (NH4)2SO4 plus the anesthetic, and acceptor large unilamellar vesicles with internal pH of 5.5. Both kinds of liposomes were composed of hydrogenated soy-phosphatidylcholine:cholesterol (2:1 mol%) and were prepared at pH 7...
2017: PloS One
https://www.readbyqxmd.com/read/28967536/liposomal-bupivacaine-for-intercostal-nerve-block-pricey-or-priceless
#14
EDITORIAL
Alessia Pedoto, David Amar
No abstract text is available yet for this article.
August 30, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28953626/comparison-of-liposomal-bupivacaine-infiltration-versus-interscalene-nerve-block-for-pain-control-in-total-shoulder-arthroplasty-a-meta-analysis-of-randomized-control-trails
#15
REVIEW
Xiuling Cao, Fang Pan
BACKGROUND: This meta-analysis aimed to compare the efficiency and safety of liposomal bupivacaine infiltration and interscalene nerve block for pain control after total shoulder arthroplasty. METHODS: A systematic search was performed in Medline (1966 to May 2017), PubMed (1966 to May 2017), Embase (1980 to May 2017), ScienceDirect (1985 to May 2017) and the Cochrane Library. Only randomized controlled trials (RCTs) were included. Reported surgical outcomes, including visual analogue scale (VAS) scores, opioid consumption, length of stay, and postoperative adverse effects including the risk of nausea and vomiting...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28945854/reduced-acute-care-costs-with-the-eras%C3%A2-minimally-invasive-transforaminal-lumbar-interbody-fusion-compared-with-conventional-minimally-invasive-transforaminal-lumbar-interbody-fusion
#16
Michael Y Wang, Hsuan Kan Chang, Jay Grossman
BACKGROUND: Enhancing Recovery After Surgery (ERAS®) programs have been widely adopted throughout the world, but not in spinal surgery. In this report, we review the implementation of a "fast track" surgery for lumbar fusion and its effect on acute care hospitalization costs. OBJECTIVE: To determine if a "fast track" surgery methodology results in acute care cost savings. METHODS: Thirty-eight consecutive ERAS patients were compared with patients undergoing conventional minimally invasive transforaminal lumbar interbody fusion...
July 28, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28919812/the-effect-of-local-topical-analgesics-on-incisional-pain-in-a-pig-model
#17
David Castel, Itai Sabbag, Sigal Meilin
Interest in the development of new topical/local drug administration for blocking pain at peripheral sites, with maximum drug activity and minimal systemic effects, is on the rise. In the review article by Kopsky and Stahl, four critical barriers in the process of research and development of topical analgesics were indicated. The active pharmaceutical ingredient (API) and the formulation are among the major challenges. The road to the development of such drugs passes through preclinical studies. These studies, if planned correctly, should serve as guidance for choosing the right API and formulation...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28905717/use-of-liposomal-bupivacaine-for-postoperative-analgesia-in-an-incisional-pain-model-in-rats-rattus-norvegicus
#18
Stacey C Kang, Katechan Jampachaisri, Travis L Seymour, Stephen A Felt, Cholawat Pacharinsak
The local anesthetic bupivacaine is valuable for perioperative analgesia, but its use in the postoperative period is limited by its short duration of action. Here, we evaluated the application of a slow-release liposomal formulation of bupivacaine for postoperative analgesia. The aim was to assess whether liposomal bupivacaine effectively attenuates postoperative mechanical and thermal hypersensitivity in a rat model of incisional pain. Rats (n = 36) were randomly assigned to 1 of 5 treatment groups: saline, 1 mL/kg SC every 12 h for 2 d; buprenorphine HCl, 0...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28858553/liposomal-bupivacaine-use-in-third-molar-impaction-surgery-innovate-study
#19
Stuart E Lieblich, Hassan Danesi
The analgesic efficacy and safety of liposomal bupivacaine (LB) in third molar extraction was evaluated in this phase 3, double-blind, placebo-controlled study of subjects undergoing bilateral third molar extraction. Subjects were randomized 2 : 1 to infiltration with LB (133 mg/10 mL) or placebo, and received opioid rescue medication as needed. Primary efficacy measure was cumulative area under the curve (AUC) of numeric rating scale (NRS) pain severity scores through 48 hours (AUC of NRS0-48) postsurgery...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/28852531/transversus-abdominis-plane-block-with-liposomal-bupivacaine-compared-to-oral-opioids-alone-for-acute-postoperative-pain-after-laparoscopic-hysterectomy-for-early-endometrial-cancer-a-cost-effectiveness-analysis
#20
Brandon-Luke L Seagle, Emily S Miller, Anna E Strohl, Anna Hoekstra, Shohreh Shahabi
BACKGROUND: To determine the cost-effectiveness of transversus abdominis plane block with liposomal bupivacaine (TAP) compared to oral opioids alone for acute postoperative pain after laparoscopic hysterectomy for early endometrial cancer. METHODS: A cost-effectiveness analysis using a decision tree structure with a 30.5 day time-horizon was used to calculate incremental cost-effectiveness ratio (ICER) values per quality-adjusted life-year (QALY). Base-case costs, probabilities, and QALY values were identified from recently published all-payer national database studies, 2017 Medicare fee-schedules, randomized trials, institutional case series, or assumed, when published values were not available...
2017: Gynecologic Oncology Research and Practice
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