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Bupivacaine liposomal

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https://www.readbyqxmd.com/read/29276247/in-reply-to-postoperative-pain-management-with-liposomal-bupivacaine-in-patients-undergoing-orthopedic-knee-and-hip-arthroplasty-at-a-community-hospital
#1
Brian Faley, Lani Dvorak, Meghan Faley
No abstract text is available yet for this article.
December 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29245214/the-efficiency-and-safety-of-local-liposomal-bupivacaine-infiltration-for-pain-control-in-total-hip-arthroplasty-a-systematic-review-and-meta-analysis
#2
REVIEW
Xin Zhang, Qing Yang, Zhi Zhang
OBJECTIVE: This meta-analysis aimed to compare the efficiency and safety of local liposomal bupivacaine infiltration and traditional cocktail analgesia for pain management in total hip arthroplasty (THA). METHODS: PubMed, Embase, Web of science, Medline, and Cochrane library databases were systematically searched. INCLUSION CRITERIA: Participants: patients planned for a THA with a diagnosis of hip osteoarthritis. INTERVENTIONS: liposomal bupivacaine was administrated in the experimental groups for pain control...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29239940/prolonged-duration-local-anesthesia-using-liposomal-bupivacaine-combined-with-liposomal-dexamethasone-and-dexmedetomidine
#3
Alina Y Rwei, Robert T Sherburne, David Zurakowski, Bruce Wang, Daniel S Kohane
BACKGROUND: The relatively short duration of effect of local anesthetics has been addressed by encapsulation in drug delivery systems. Codelivery with a single compound that produces an adjuvant effect on nerve block but without intrinsic local anesthetic properties can further prolong the nerve block effect. Here, we investigated whether codelivery of more than 1 encapsulated adjuvant compound can further enhance nerve blockade. METHODS: Liposomes loaded with bupivacaine (Bup), dexamethasone phosphate (DexP), or dexmedetomidine (DMED) were synthesized and its in vitro drug release profiles were determined...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29226150/transversus-abdominis-plane-block-an-updated-review-of-anatomy-and-techniques
#4
REVIEW
Hsiao-Chien Tsai, Takayuki Yoshida, Tai-Yuan Chuang, Sheng-Feng Yang, Chuen-Chau Chang, Han-Yun Yao, Yu-Ting Tai, Jui-An Lin, Kung-Yen Chen
Purpose of Review: Transversus abdominis plane (TAP) block is a regional technique for analgesia of the anterolateral abdominal wall. This review highlights the nomenclature system and recent advances in TAP block techniques and proposes directions for future research. Recent Findings: Ultrasound guidance is now considered the gold standard in TAP blocks. It is easy to acquire ultrasound images; it can be used in many surgeries involving the anterolateral abdominal wall...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29215511/liposomal-bupivacaine-during-robotic-colpopexy-and-posterior-repair-a-randomized-controlled-trial
#5
Jennifer Yeung, Catrina C Crisp, Donna Mazloomdoost, Steven D Kleeman, Rachel N Pauls
OBJECTIVE: To evaluate the effect of liposomal bupivacaine on postoperative pain among patients undergoing robotic sacrocolpopexy with posterior repair. METHODS: This was a randomized, patient-blinded, placebo-controlled trial of women undergoing robotic sacrocolpopexy with posterior repair. Liposomal bupivacaine or normal saline placebo was injected into laparoscopic and vaginal incisions at completion of surgery. Perioperative care was standardized. Visual analog scales were collected at 4, 18, and 24 hours postoperatively in hospital...
January 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29208329/the-effects-of-body-mass-index-on-pain-control-with-liposomal-bupivacaine-in-hip-and-knee-arthroplasty
#6
Abigail L Campbell, Stephen Yu, Raj Karia, Richard Iorio, Steven A Stuchin
BACKGROUND: There is evidence to suggest that liposomal bupivacaine (LB) is an effective component of a multimodal pain regimen for total joint arthroplasty (TJA). Obesity has been associated with chronic pain following TJA. This study assessed whether early postoperative pain is affected by body mass index (BMI), and whether the standard LB dose has similar effects on obese vs nonobese patients. METHODS: A retrospective analysis of 2629 primary TJA over a 12-month period was conducted, with LB used in half of this group...
November 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29204926/alginate-liposomal-construct-for-bupivacaine-delivery-and-msc-function-regulation
#7
Mollie S Davis, Ileana Marrero-Berrios, Xiomara I Perez, Timothy Maguire, Palangat Radhakrishnan, Devasena Manchikalapati, Joseph SchianodiCola, Hattiyangangadi Kamath, Rene S Schloss, Joel Yarmush
Mesenchymal stromal cell (MSC) therapies have become potential treatment options for multiple ailments and traumatic injuries. In the clinical setting, MSC are likely to be co-administered with local anesthetics (LA) which have been shown to have dose- and potency-dependent detrimental effects on the viability and function of cells. We previously developed and characterized a sustained-release LA delivery formulation comprised of alginate-encapsulated liposomal bupivacaine. The current studies were designed to evaluate the effect of this formulation on the secretion of three key MSC regulatory molecules, interleukin 6 (IL-6), prostaglandin E2 (PGE2), and transforming growth factor-beta 1 (TGF-β1)...
December 4, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29194065/delayed-respiratory-depression-secondary-to-opioid-overdose-after-multimodal-analgesia-with-transversus-abdominis-plane-blocks-in-postanesthesia-care-unit-a-case-report
#8
Michael O'Rourke, Emily S Schmidt, Jonathan E Metry, Michael B Majewski
Pain control after open abdominal surgery often includes multimodal analgesia with thoracic epidural or transversus abdominis plane (TAP) block. After liposomal bupivacaine was approved for TAP blocks in 2015, it became an alternative to indwelling catheters. However, the pharmacokinetics and safety of its use during the perioperative period have not been thoroughly investigated, especially in conjunction with parenteral opioids. We present a case report of an elderly patient having urgent laparoscopic converted to open abdominal surgery, who experienced postoperative respiratory depression in the recovery room after multimodal therapy with liposomal bupivacaine TAP blocks, intravenous (IV) opioids, and ketorolac...
November 30, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29189284/the-use-of-liposomal-bupivacaine-in-erector-spinae-plane-block-to-minimize-opioid-consumption-for-breast-surgery-a-case-report
#9
Amanda Kumar, Alina Hulsey, Hector Martinez-Wilson, James Kim, Jeff Gadsden
The erector spinae plane block is a novel interfascial plane block that can provide thoracic and abdominal analgesia. We describe a patient with opioid intolerance scheduled for breast surgery who received an erector spinae plane block with liposomal bupivacaine as well as a supplemental T1 paravertebral block resulting in profound analgesia throughout her postoperative course. This case report demonstrates that use of liposomal bupivacaine in the erector spinae plane block can be successful in providing extended duration postoperative analgesia and minimizing systemic opioid requirements...
November 16, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29163750/long-acting-liposomal-bupivacaine-for-percutaneous-sympathetic-stellate-ganglion-blockade-a-technical-note
#10
Adnan I Qureshi, Muhammad A Waqas, Vikram Jadhav, Muhammad A Saleem, Jeff Campbell, Shawn S Wallery
Introduction: We describe the use of long acting liposomal bupivacaine for percutaneous stellate ganglion blockade to treat severe headaches following internal carotid artery dissection. Methods: A 43-year old woman developed right-sided refractory headache after right internal carotid artery dissection. Patient underwent percutaneous stellate ganglion block using bupivacaine hydrochloride (0.25%-20 ml) in the past with short acting relief. Liposomal bupivacaine (EXPAREL) 13...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29126979/ropivacaine-and-bupivacaine-prevent-increased-pain-sensitivity-without-altering-neuroimmune-activation-following-repeated-social-defeat-stress
#11
Caroline M Sawicki, January K Kim, Michael D Weber, Brant L Jarrett, Jonathan P Godbout, John F Sheridan, Michelle Humeidan
OBJECTIVE: Mounting evidence indicates that stress influences the experience of pain. Exposure to psychosocial stress disrupts bi-directional communication pathways between the central nervous system and peripheral immune system, and can exacerbate the frequency and severity of pain experienced by stressed subjects. Repeated social defeat (RSD) is a murine model of psychosocial stress that recapitulates the immune and behavioral responses to stress observed in humans, including activation of stress-reactive neurocircuitry and increased pro-inflammatory cytokine production...
November 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29108087/bupivacaine-versus-liposomal-bupivacaine-for-pain-control
#12
Siavash Beiranvand, Mahmoud Reza Moradkhani
Local infiltrations and regional blocks have been some of the effective ways employed to manage and control post-operative pain. One of the limitations of administration of local anesthesia drugs in post-operative conditions is its inability to act for a longer period of time. Multi-vesicular liposomes made up of bupivacaine have been progressively used for their increased duration of action. Compared to bupivacaine HCL, local infiltration of liposomal bupivacaine have shown to have a significantly increase the duration and delay in peak plasma concentration...
November 6, 2017: Drug Research
https://www.readbyqxmd.com/read/29095194/liposomal-bupivacaine-may-benefit-select-reduction-mammaplasty-patients
#13
Shana S Kalaria, Stefanos Boukovalas, Pablo L Padilla, Jacquelynn P Tran, Ramon T Li, Linda G Phillips
BACKGROUND: Postoperative pain control can be challenging in reduction mammaplasty patients. This study compares perioperative liposomal bupivacaine (Exparel; Pacira Pharmaceuticals, Inc, San Diego, Calif) with standard local anesthetics to determine if liposomal bupivacaine decreases opioid and antiemetic use, impacting length of stay and complication rates, thus improving patient outcomes. METHODS: A retrospective review of 170 reduction mammaplasty patients was performed...
October 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29067198/an-extended-release-local-anaesthetic-potential-for-future-use-in-veterinary-surgical-patients
#14
REVIEW
B Duncan X Lascelles, Kristin Kirkby Shaw
One of the most effective means of preventing the transduction and transmission of acute and perioperative pain is through the use of local anaesthetics. However, local anaesthetics currently available have a relatively short duration of action. Although there are several tools available to treat perioperative pain in companion animals, overall, there is an unmet need for products that can be administered in the clinic, and provide pain relief for the crucial first few days following surgery in the home environment...
November 2016: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29065741/intra-incisional-liposomal-bupivacaine-and-its-impact-on-post-cesarean-analgesia-a-retrospective-study
#15
Pavan Parikh, Imran Sunesara, Sukhpreet Singh Multani, Brandy Patterson, Elizabeth Lutz, James N Martin
PURPOSE: The efficacy of long acting intra-incisional bupivacaine in reducing postoperative opioid use amongst women who have undergone a cesarean is currently unknown. MATERIALS AND METHODS: This was a retrospective case-control study with a 1:1 allocation. We identified 40 patients in each group, for a total of 80. The treatment group was administered 266 mg of liposomal bupivacaine after completion of the cesarean and was compared to historical controls. Data regarding anesthesia administered, opioid consumption, nonsteroidal anti-inflammatory use, acetaminophen use, type of cesarean, reason for cesarean and length of postoperative stay were recorded...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29062649/multimodal-analgesia-in-breast-surgical-procedures-technical-and-pharmacological-considerations-for-liposomal-bupivacaine-use
#16
Anoushka M Afonso, Martin I Newman, Neil Seeley, Jacob Hutchins, Kevin L Smith, Gabriel Mena, Jesse C Selber, Michel H Saint-Cyr, Jeffrey C Gadsden
Enhanced recovery after surgery is a multidisciplinary perioperative clinical pathway that uses evidence-based interventions to improve the patient experience as well as increase satisfaction, reduce costs, mitigate the surgical stress response, accelerate functional recovery, and decrease perioperative complications. One of the most important elements of enhanced recovery pathways is multimodal pain management. Herein, aspects relating to multimodal analgesia following breast surgical procedures are discussed with the understanding that treatment decisions should be individualized and guided by sound clinical judgment...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29061282/analgesic-efficacy-of-laparoscopic-guided-transverse-abdominis-plane-block-using-liposomal-bupivacaine-in-bariatric-surgery
#17
Avinash Bhakta, Owen Glotzer, Ashar Ata, Marcel Tafen, Steven C Stain, Paul T Singh
BACKGROUND: Postoperative pain management is a major contributor to recovery and discharge in bariatric surgery. Local anesthetic agents are of particular interest: they're non-sedating and may reduce postoperative pain and hospital length of stay (LOS). DESIGN: Researchers queried the Bariatric Surgery Service Database for patients undergoing laparoscopic weight loss surgery from January 2012-December 2014. Patients were divided between those who did and did not receive liposomal bupivacaine intra-operatively...
September 20, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29055733/qx-oh-levobupivacaine-fixed-dose-combination-to-provide-a-long-acting-postoperative-pain-of-knee-surgery-in-rodents
#18
WenLing Zhao, Jun Yang, YuJun Zhang, Jin Liu, WenSheng Zhang
Although total knee arthroplasty (TKA) is a commonly performed procedure, anesthetic efficacy in post-surgical pain remains an issue. Exparel (45mM liposome bupivacaine), a relatively long-acting local anesthetic, has shown efficacy in blocking peripheral nerve or periarticular infiltration to achieve better post-TKA analgesia. In the present work, we tested whether a fixed-dose combination of QX-OH (35mM) and levobupivacaine (10mM) (QX-OH/LB) could confer longer-lasting pain relief and reduce periarticular tissue toxicity compared to liposome bupivacaine (45mM) after TKA operation...
October 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29033152/intraoperative-infiltration-of-liposomal-bupivacaine-vs-bupivacaine-hydrochloride-for-pain-management-in-primary-total-hip-arthroplasty-a-prospective-randomized-trial
#19
Itay Perets, John P Walsh, Brian H Mu, Leslie C Yuen, Lyall Ashberg, Muriel R Battaglia, Benjamin G Domb
BACKGROUND: Pain management after total hip arthroplasty is well studied. Nevertheless, there is no consensus regarding the "cocktail" to use in periarticular infiltration (PAI). Liposomal bupivacaine (LB) is a slow release local anesthetic that can be infiltrated during surgery. In this study, we compared LB to bupivacaine hydrochloride (HCL). METHODS: Between September 2014 and March 2016, 181 patients were screened for this prospective randomized trial. A total of 107 patients were enrolled and studied...
September 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29016551/pectoral-fascial-pecs-i-and-ii-blocks-as-rescue-analgesia-in-a-patient-undergoing-minimally-invasive-cardiac-surgery
#20
Suraj Yalamuri, Rebecca Y Klinger, W Michael Bullock, Donald D Glower, Brandi A Bottiger, Jeffrey C Gadsden
INTRODUCTION: Patients undergoing minimally invasive cardiac surgery have the potential for significant pain from the thoracotomy site. We report the successful use of pectoral nerve block types I and II (Pecs I and II) as rescue analgesia in a patient undergoing minimally invasive mitral valve repair. CASE REPORT: In this case, a 78-year-old man, with no history of chronic pain, underwent mitral valve repair via right anterior thoracotomy for severe mitral regurgitation...
November 2017: Regional Anesthesia and Pain Medicine
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