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Regenerative Tissue

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https://www.readbyqxmd.com/read/28454251/laparoscopic-resection-of-a-sigmoid-colon-lipoma-in-a-young-female-patient-a-case-report-and-review-of-the-literature
#1
Georgios I Panagiotakis, Alexandros G Andreou, Ioannis E Petrakis, Maria Tzardi, Maria Daskalogiannaki, Georgios E Chalkiadakis
Lipomas of the sigmoid colon are rare entities. The present case describes a 27-year-old Caucasian woman who underwent a laparoscopic sigmoidectomy following the detection of a giant lipoma. The young patient was referred to the Emergency Department of the University Hospital of Heraklion (Crete, Greece) in May 2013 after experiencing intermittent abdominal cramping during defecation, and altering episodes of diarrhea and constipation. In addition, the patient described the protrusion of a solid tissue mass shaped like a 'champagne bottle cork' from the anus following defecation...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453955/acoustic-tweezing-cytometry-enhances-osteogenesis-of-human-mesenchymal-stem-cells-through-cytoskeletal-contractility-and-yap-activation
#2
Xufeng Xue, Xiaowei Hong, Zida Li, Cheri X Deng, Jianping Fu
Human mesenchymal stem cells (hMSCs) have great potential for cell-based therapies for treating degenerative bone diseases. It is known that mechanical cues in the cell microenvironment play an important role in regulating osteogenic (bone) differentiation of hMSCs. However, mechanoregulation of lineage commitment of hMSCs in conventional two-dimensional (2D) monocultures or bioengineered three-dimensional (3D) tissue constructs remains suboptimal due to complex biomaterial design criteria for hMSC culture...
April 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28453486/cognitive-deficits-after-cerebral-ischemia-and-underlying-dysfunctional-plasticity-potential-targets-for-recovery-of-cognition
#3
Holly M Stradecki-Cohan, Charles H Cohan, Ami P Raval, Kunjan R Dave, Diego Reginensi, Rolando A Gittens, Mehdi Youbi, Miguel A Perez-Pinzon
Cerebral ischemia affects millions of people worldwide and survivors suffer from long-term functional and cognitive deficits. While stroke and cardiac arrest are typically considered when discussing ischemic brain injuries, there is much evidence that smaller ischemic insults underlie neurodegenerative diseases, including Alzheimer's disease. The "regenerative" capacity of the brain relies on several aspects of plasticity that are crucial for normal functioning; less affected brain areas may take over function previously performed by irreversibly damaged tissue...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28453285/pharmacological-reprogramming-of-somatic-cells-for-regenerative-medicine
#4
Min Xie, Shibing Tang, Ke Li, Sheng Ding
Lost or damaged cells in tissues and organs can be replaced by transplanting therapeutically competent cells. This approach requires methods that effectively manipulate cellular identities and properties to generate sufficient numbers of desired cell types for transplantation. These cells can be generated by reprogramming readily available somatic cells, such as fibroblasts, into induced pluripotent stem cells (iPSCs), which can replicate indefinitely and give rise to any somatic cell type. This reprogramming can be achieved with genetic methods, such as forced expression of pluripotency-inducing transcription factors (TFs), which can be further improved, or even avoided, with pharmacological agents...
April 28, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28448819/construction-of-three-dimensional-vascularized-functional-human-liver-tissue-using-a-layer-by-layer-cell-coating-technique
#5
Kazuki Sasaki, Takami Akagi, Tadafumi Asaoka, Hidetoshi Eguchi, Yasunari Fukuda, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Koichi Kawamoto, Yuichiro Doki, Masaki Mori, Mitsuru Akashi
The creation of artificial liver tissue is an active area of research due to the shortage of donors for liver transplantation. Here we investigated whether a simple and efficient cell coating technique developed in our laboratory could be used to generate functional vascularized liver tissue. This technique creates three-dimensional tissue by loading cells sterically onto other cells that have been coated with layer-by-layer (LbL) nanofilms of fibronectin and gelatin, two extracellular matrix proteins. We used this technique to construct homogenous, dense, well-vascularized liver tissue from cryopreserved human primary hepatocytes, human umbilical vein endothelial cells, and normal human dermal fibroblasts...
February 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/28448316/regenerative-medicine-and-stem-cells-in-dermatology
#6
Eduardo K Moioli, Diana Bolotin, Murad Alam
BACKGROUND: Clinically relevant regenerative medicine is still in its early stages of development. Difficulties in regenerating large-scale and complex structures, the lack of safety data, and the paucity of clinical trials have slowed the process of technological advance. OBJECTIVE: To familiarize the clinician with techniques available in the laboratory and experimental approaches being tested clinically. In addition, a layout is discussed for how dermatologists can lead the way in bringing regenerative medicine to clinical reality...
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28448039/surgical-ablation-assay-for-studying-eye-regeneration-in-planarians
#7
Jacob M Morton, Marwa A Saad, Wendy S Beane
In the study of adult stem cells and regenerative mechanisms, planarian flatworms are a staple in vivo model system. This is due in large part to their abundant pluripotent stem cell population and ability to regenerate all cell and tissue types after injuries that would be catastrophic for most animals. Recently, planarians have gained popularity as a model for eye regeneration. Their ability to regenerate the entire eye (comprised of two tissue types: pigment cells and photoreceptors) allows for the dissection of the mechanisms regulating visual system regeneration...
April 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447991/isolation-and-characterization-of-mesenchymal-stromal-cells-from-human-umbilical-cord-and-fetal-placenta
#8
Naimisha Beeravolu, Christina McKee, Ali Alamri, Sasha Mikhael, Christina Brown, Mick Perez-Cruet, G Rasul Chaudhry
The human umbilical cord (UC) and placenta are non-invasive, primitive and abundant sources of mesenchymal stromal cells (MSCs) that have increasingly gained attention because they do not pose any ethical or moral concerns. Current methods to isolate MSCs from UC yield low amounts of cells with variable proliferation potentials. Since UC is an anatomically-complex organ, differences in MSC properties may be due to the differences in the anatomical regions of their isolation. In this study, we first dissected the cord/placenta samples into three discrete anatomical regions: UC, cord-placenta junction (CPJ), and fetal placenta (FP)...
April 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447989/fabrication-of-extracellular-matrix-derived-foams-and-microcarriers-as-tissue-specific-cell-culture-and-delivery-platforms
#9
Anna Kornmuller, Cody F C Brown, Claire Yu, Lauren E Flynn
Cell function is mediated by interactions with the extracellular matrix (ECM), which has complex tissue-specific composition and architecture. The focus of this article is on the methods for fabricating ECM-derived porous foams and microcarriers for use as biologically-relevant substrates in advanced 3D in vitro cell culture models or as pro-regenerative scaffolds and cell delivery systems for tissue engineering and regenerative medicine. Using decellularized tissues or purified insoluble collagen as a starting material, the techniques can be applied to synthesize a broad array of tissue-specific bioscaffolds with customizable geometries...
April 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447974/3d-whole-heart-myocardial-tissue-analysis
#10
Hans Thijs Van den Broek, Leon De Jong, Pieter A Doevendans, Steven A J Chamuleau, Frebus J Van Slochteren, René Van Es
Cardiac regenerative therapies aim to protect and repair the injured heart in patients with ischemic heart disease. By injecting stem cells or other biologicals that enhance angio- or vasculogenesis into the infarct border zone (IBZ), tissue perfusion is improved, and the myocardium can be protected from further damage. For maximum therapeutic effect, it is hypothesized that the regenerative substance is best delivered to the IBZ. This requires accurate injections and has led to the development of new injection techniques...
April 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447755/gene-expression-profile-in-human-induced-pluripotent-stem-cells-chondrogenic-differentiation-in-vitro-part-a
#11
Wiktoria Maria Suchorska, Ewelina Augustyniak, Magdalena Richter, Tomasz Trzeciak
Human induced pluripotent stem cells (hiPSCs) offer promise in regenerative medicine, however more data are required to improve understanding of key aspects of the cell differentiation process, including how specific chondrogenic processes affect the gene expression profile of chondrocyte‑like cells and the relative value of cell differentiation markers. The main aims of the present study were as follows: To determine the gene expression profile of chondrogenic-like cells derived from hiPSCs cultured in mediums conditioned with HC‑402‑05a cells or supplemented with transforming growth factor β3 (TGF‑β3), and to assess the relative utility of the most commonly used chondrogenic markers as indicators of cell differentiation...
March 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28446966/monocytes-and-macrophages-in-cardiac-injury-and-repair
#12
REVIEW
Hendrik B Sager, Thorsten Kessler, Heribert Schunkert
Myocardial infarction (MI) is one of the major contributors to worldwide morbidity and mortality. It is atherosclerosis' most dreadful complication and occurs after the supply of oxygenated blood to the heart is blocked. Understanding how cardiac tissue is injured and later regenerates is of crucial importance to improve the sequelae after the acute event. We now understand that the immune system substantially contributes to both the acute inflammatory response and the regenerative response that follow tissue injury after MI...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446226/xenotransplantation-of-interferon-gamma-pretreated-clumps-of-a-human-mesenchymal-stem-cell-extracellular-matrix-complex-induces-mouse-calvarial-bone-regeneration
#13
Kei Takeshita, Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara
BACKGROUND: Three-dimensional cultured clumps of a mesenchymal stem cell (MSC)/extracellular matrix (ECM) complex (C-MSC) consists of cells and self-produced ECM. C-MSC can regulate the cellular function in vitro and induce successful bone regeneration using ECM as a cell scaffold. Potentiating the immunomodulatory capacity of C-MSCs, which can ameliorate the allo-specific immune response, may be helpful in developing beneficial "off-the-shelf" cell therapy for tissue regeneration. It is well reported that interferon (IFN)-γ stimulates the immunosuppressive properties of MSC via upregulation of the immunomodulatory enzyme IDO...
April 26, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28446218/increased-galectin-3-may-serve-as-a-serologic-signature-of-pre-rheumatoid-arthritis-while-markers-of-synovitis-and-cartilage-do-not-differ-between-early-undifferentiated-arthritis-subsets
#14
Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M Lindegaard, Jakob M Møller, Peter Junker
BACKGROUND: Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a proinflammatory mediator, and seromarkers of structural joint elements in patients with early, UA and their associations with disease profile and biochemical and imaging findings. METHODS: One hundred and eleven UA patients were followed-up for at least 12 months and reclassified according to appropriate criteria (TUDAR)...
April 26, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28445734/opposing-actions-of-fgf8a-on-notch-signaling-distinguish-two-muller-glial-cell-populations-that-contribute-to-retina-growth-and-regeneration
#15
Jin Wan, Daniel Goldman
The teleost retina grows throughout life and exhibits a robust regenerative response following injury. Critical to both these events are Muller glia (or, Muller glial cells; MGs), which produce progenitors for retinal growth and repair. We report that Fgf8a may be an MG niche factor that acts through Notch signaling to regulate spontaneous and injury-dependent MG proliferation. Remarkably, forced Fgf8a expression inhibits Notch signaling and stimulates MG proliferation in young tissue but increases Notch signaling and suppresses MG proliferation in older tissue...
April 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28445691/tis11-mediated-mrna-decay-promotes-the-reacquisition-of-drosophila-intestinal-stem-cell-quiescence
#16
Lindy McClelland, Heinrich Jasper, Benoît Biteau
Adult stem cell proliferation rates are precisely regulated to maintain long-term tissue homeostasis. Defects in the mechanisms controlling stem cell proliferation result in impaired regeneration and hyperproliferative diseases. Many stem cell populations increase proliferation in response to tissue damage and reacquire basal proliferation rates after tissue repair is completed. Although proliferative signals have been extensively studied, much less is known about the molecular mechanisms that restore stem cell quiescence...
April 23, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28445607/fractal-characteristics-of-the-microvascular-network-a-useful-index-to-assess-vascularization-level-of-porous-silk-fibroin-biomaterial
#17
Kuihua Zhan, Lun Bai, Qinqin Wu, Derong Lei, Guangqian Wang
The neovascularization of biomaterials for tissue engineering is not only related to growth of capillaries but also involves appropriate hierarchy distribution of the microvessels. In this study, we proposed hierarchy distribution contrast method which can assess vascular transport capacity, in order to examine the hierarchy distribution of the neovessels during vascularization of the porous silk fibroin biomaterials implanted into rats and its evolution. The results showed that the fractal characteristics appeared toward the end of the vascularization stages, and the structure of the microvascular network after 3 weeks of implantation was similar to the fractal microvascular tree with bifurcation exponent x=3 and fractal dimension D=1...
April 26, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28445529/ductular-reaction-correlates-with-fibrogenesis-but-does-not-contribute-to-liver-regeneration-in-experimental-fibrosis-models
#18
András Rókusz, Dániel Veres, Armanda Szücs, Edina Bugyik, Miklós Mózes, Sándor Paku, Péter Nagy, Katalin Dezső
BACKGROUND AND AIMS: Ductular reaction is a standard component of fibrotic liver tissue but its function is largely unknown. It is supposed to interact with the matrix producing myofibroblasts and compensate the declining regenerative capacity of hepatocytes. The relationship between the extent of fibrosis-ductular reaction, proliferative activity of hepatocytes and ductular reaction were studied sequentially in experimental hepatic fibrosis models. METHODS: Liver fibrosis/cirrhosis was induced in wild type and TGFβ overproducing transgenic mice by carbon tetrachloride and thioacetamide administration...
2017: PloS One
https://www.readbyqxmd.com/read/28445518/use-of-human-fat-grafting-in-the-prevention-of-perineural-adherence-experimental-study-in-athymic-mouse
#19
Mario Cherubino, Igor Pellegatta, Alessandro Crosio, Luigi Valdatta, Stefano Geuna, Rosalba Gornati, Pierluigi Tos
Perineural adherences represent a problem after surgery involving peripheral neural system. Fat-grafting with adipose derived stem cells (ASCs) with their pro-regenerative characteristics can be important to prevent the neural damage or to facilitate the neural regeneration. Our idea was to use the fat-grafting as an anti-adherence device and test its efficacy on a postsurgical scar animal model and comparing to an antiadhesive gel. 32 athymic mice were operated under magnification, we exposed both sciatic nerves...
2017: PloS One
https://www.readbyqxmd.com/read/28445085/regenerative-surgery-in-the-treatment-of-cosmetic-defect-following-nuss-procedure
#20
Flavio Facchini, Marco Ghionzoli, Alessandra Martin, Sara Tanini, Sara Ugolini, Roberto Lo Piccolo, Antonio Messineo
BACKGROUND: In the past decade, the minimally invasive repair of pectus excavatum (MIRPE) has become the treatment of choice for severe pectus excavatum (PE), proving acceptable to excellent cosmetic results. Recently, autologous fat grafting (FG) has been identified in aesthetic and reconstructive surgery to ideally handle volume and contour defects. We report our experience about FG in the treatment of residual minor defects after MIRPE and a proposal for a new indication of this largely adopted technique...
April 26, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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