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Regenerative Tissue

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https://www.readbyqxmd.com/read/29341292/amniotic-fluid-stem-cell-exosomes-therapeutic-perspective
#1
Francesca Beretti, Manuela Zavatti, Francesca Casciaro, Giuseppina Comitini, Fabrizia Franchi, Veronica Barbieri, Giovanni B La Sala, Tullia Maraldi
It is widely accepted that the therapeutic potential of stem cells can be largely mediated by paracrine factors, also included into exosomes. Thus, stem cell-derived exosomes represent a major therapeutic option in regenerative medicine avoiding, if compared to stem cells graft, abnormal differentiation and tumor formation. Exosomes derived from mesenchymal stem cells (MSC) induce damaged tissue repair, and can also exert immunomodulatory effects on the differentiation, activation and function of different lymphocytes...
January 16, 2018: BioFactors
https://www.readbyqxmd.com/read/29340876/biomaterials-and-regenerative-medicine-in-urology
#2
N F Davis, E M Cunnane, M R Quinlan, J J Mulvihill, N Lawrentschuk, D M Bolton, M T Walsh
Autologous gastrointestinal tissue is the gold standard biomaterial for urinary tract reconstruction despite its long-term neuromechanical and metabolic complications. Regenerative biomaterials have been proposed as alternatives; however many are limited by a poor host derived regenerative response and deficient supportive elements for effective tissue regeneration in vivo. Urological biomaterials are sub-classified into xenogenic extracellular matrices (ECMs) or synthetic polymers. ECMs are decellularised, biocompatible, biodegradable biomaterials derived from animal organs...
January 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29339509/biodegradable-piezoelectric-force-sensor
#3
Eli J Curry, Kai Ke, Meysam T Chorsi, Kinga S Wrobel, Albert N Miller, Avi Patel, Insoo Kim, Jianlin Feng, Lixia Yue, Qian Wu, Chia-Ling Kuo, Kevin W-H Lo, Cato T Laurencin, Horea Ilies, Prashant K Purohit, Thanh D Nguyen
Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339286/chitosan-an-undisputed-bio-fabrication-material-for-tissue-engineering-and-bio-sensing-applications
#4
REVIEW
Anupriya Baranwal, Ashutosh Kumar, A Priyadharshini, Gopi Suresh Oggu, Ira Bhatnagar, Ananya Srivastava, Pranjal Chandra
Biopolymers have been serving the mankind in various ways since long. Over the last few years, these polymers have found great demand in various domains which includes biomedicine, tissue engineering, biosensor fabrications etc. because of their excellent biocompatibility. In this context, chitosan has found global attention due to its environmentally benign nature, biocompatibility, biodegradability, and ease of availability. In last one decade or so, extensive research in active biomaterials, like chitosan has led to the development of novel delivery systems for drugs, genes, and biomolecules; and regenerative medicine...
January 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29339111/stem-cells-for-urinary-incontinence-functional-differentiation-or-cytokine-effects
#5
REVIEW
Bradley C Gill, Daniel Z Sun, Margot S Damaser
Minimally-invasive stem cell therapy for stress urinary incontinence may provide an effective nonsurgical treatment for this common condition. Clinical trials of periurethral stem cell injection have been underway and basic science research has demonstrated the efficacy of both local and systemic stem cell therapies. Results differ as to whether stem cells have a therapeutic effect by differentiating into permanent, functional tissues, or whether they exert benefits through a transient presence and the secretion of regenerative factors...
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29338385/does-the-mesenchymal-stem-cell-source-influence-smooth-muscle-regeneration-in-tissue-engineered-urinary-bladders
#6
Marta Pokrywczynska, Arkadiusz Jundzill, Karolina Warda, Lukasz Buchholz, Marta Rasmus, Jan Adamowicz, Magdalena Bodnar, Andrzej Marszalek, Anna Helmin-Basa, Jacek Michalkiewicz, Maciej Gagat, Alina Grzanka, Malgorzata Frontczak-Baniewicz, Agata Magdalena Gastecka, Tomasz Kloskowski, Maciej Nowacki, Camillo Ricordi, Tomasz Drewa
A variety of tissue engineering techniques utilizing different cells and biomaterials are currently being explored to construct urinary bladder walls de novo, but so far no approach is clearly superior. The aim of this study was to determine whether mesenchymal stem cells (MSCs) isolated from different sources, (bone marrow [BM-MSCs] and adipose tissue [ADSCs]), differ in their potential to regenerate smooth muscles in tissue-engineered urinary bladders and to determine an optimal number of MSCs for urinary bladder smooth muscle regeneration...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29337900/age-related-epigenetic-derangement-upon-reprogramming-and-differentiation-of-cells-from-the-elderly
#7
REVIEW
Francesco Ravaioli, Maria G Bacalini, Claudio Franceschi, Paolo Garagnani
Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated...
January 16, 2018: Genes
https://www.readbyqxmd.com/read/29337647/compositional-assessment-of-human-tracheal-cartilage-by-infrared-spectroscopy
#8
Gary Linkov, Arash Hanifi, Farzad Yousefi, Derrick Tint, Sudheer Bolla, Nathanial Marchetti, Ahmed M S Soliman, Nancy Pleshko
Objectives To assess the potential of infrared fiber-optic spectroscopy to evaluate the compositional properties of human tracheal cartilage. Study Design Laboratory-based study. Methods Twenty human cadaveric distal tracheas were harvested (age range 20-78 years; 6 females, 14 males) for compositional analysis. Histologic staining, Fourier transform infrared imaging spectroscopy data on collagen and proteoglycan (PG) content, and near-infrared (NIR) fiber-optic probe spectroscopic data that reflect protein and water content were evaluated...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29337123/mesenchymal-stem-cell-based-therapy-improves-lower-limb-movement-after-spinal-cord-ischemia-in-rats
#9
Shinya Takahashi, Kei Nakagawa, Mayumi Tomiyasu, Ayumu Nakashima, Keijiro Katayama, Takeshi Imura, Bagus Herlambang, Fumie Okubo, Koji Arihiro, Yumi Kawahara, Louis Yuge, Taijiro Sueda
BACKGROUND: Spinal cord ischemia is a devastating complication following thoracic and thoracoabdominal aortic surgery. In this study, we aimed to investigate the effects of mesenchymal stem cells (MSCs), which have regenerative capability and exert paracrine actions on damaged tissues, injected into rat models of spinal cord ischemia-reperfusion injury. METHODS: Forty-five Sprague-Dawley rats were divided into sham, phosphate-buffered saline (PBS), and MSC groups...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29336778/damage-induced-reactive-oxygen-species-regulate-vimentin-and-dynamic-collagen-based-projections-to-mediate-wound-repair
#10
Danny LeBert, Jayne M Squirrell, Chrissy Freisinger, Julie Rindy, Netta Golenberg, Grace Frecentes, Angela Gibson, Kevin W Eliceiri, Anna Huttenlocher
Tissue injury leads to early wound-associated reactive oxygen species (ROS) production that mediate tissue regeneration. To identify mechanisms that function downstream of redox signals that modulate regeneration, a vimentin reporter of mesenchymal cells was generated by driving GFP from the vimentin promoter in zebrafish. Early redox signaling mediated vimentin reporter activity at the wound margin. Moreover, both ROS and vimentin were necessary for collagen production and reorganization into projections at the leading edge of the wound...
January 16, 2018: ELife
https://www.readbyqxmd.com/read/29336267/stem-cells-derived-from-amniotic-fluid-a-potential-pluripotent-like-cell-source-for-cellular-therapy
#11
Thamil Selvee Ramasamy, Vithya Velaithan, Yelena Yeow, Fazlul H Sarkar
BACKGROUND: Regenerative medicine aims to provide therapeutic treatment for disease or injury, and cell-based therapy is a newer therapeutic approach that the conventional medicine cannot do. The ethical issues rose by the utilisation of human embryonic stem cells (hESC) and the limited capacity of adult stem cells, however, hinder the application of these stem cells in regenerative medicine. Recently, isolation and characterisation of c-kit positive cells from human amniotic fluid, which possess intermediate characteristics between hESCs and adult stem cells, provided a new approach towards realising their promise for fetal and adult regenerative medicine...
January 14, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29335337/salivary-glands-regenerate-after-radiation-injury-through-sox2-mediated-secretory-cell-replacement
#12
Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz-Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, William R Ryan, Aaron D Tward, Sarah M Knox
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co-morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by targeted therapeutics. However, the identity of these cells, whether they are capable of regenerating the tissue, and the mechanisms by which they are regulated are unknown. Using in vivo and ex vivo models, in combination with genetic lineage tracing and human tissue, we discover a SOX2+ stem cell population essential to acinar cell maintenance that is capable of replenishing acini after radiation...
January 15, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29335199/3-d-mineralized-silk-fibroin-polycaprolactone-composite-scaffold-modified-with-polyglutamate-conjugated-with-bmp-2-peptide-for-bone-tissue-engineering
#13
Jingjing Luo, Haitao Zhang, Jiang Zhu, Xiaokang Cui, Junjiu Gao, Xin Wang, Jie Xiong
In the field of bone tissue engineering, an ideal three-dimensional (3-D) scaffold should not only structurally mimic the extracellular matrix (ECM) in large tissues but also mechanically support the bone healing process and provide biochemical cues to induce osteogenesis. In this study, we investigated the feasibility of functionalisation of scaffolds by coupling polyglutamate acid conjugated with BMP-2 peptide onto silk fibroin (SF)/polycaprolactone (PCL) (SF/PCL) blend nanofibers. The morphology, composition, and mineralisation, were confirmed by FE-SEM, XRD, and FT-IR spectroscopy...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29334850/an-immunopathological-evaluation-of-the-porcine-cholecyst-matrix-as-a-muscle-repair-graft-in-a-male-rat-abdominal-wall-defect-model
#14
Dhanush Krishna Balakrishnan-Nair, Narayanan Divakaran Nair, Syam Kunnekkattu Venugopal, Vijayan Narayana Das, Sisilamma George, Mammen John Abraham, Saji Eassow, Malcolm Ronald Alison, Anoop Sainulabdeen, Thapasimuthu Vijayamma Anilkumar
With the increasing use of animal-based biomaterials for regenerative medical applications, the need for their safety assessment is paramount. A porcine cholecyst-derived scaffold (CDS), intended as a muscle repair graft, prepared by a nondetergent/enzymatic method was engrafted in a rat abdominal wall defect model. Host tissue-scaffold interface samples were collected 2, 8, and 16 weeks postimplantation and evaluated by histopathology, immunohistochemistry, and electron microscopy. The nature of the tissue reaction was compared with those induced by a jejunum-derived scaffold (JDS) prepared by the same method and a commercial-grade small intestinal submucosa (CSIS) scaffold...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29334800/research-progress-of-self-assembled-nanogel-and-hybrid-hydrogel-systems-based-on-pullulan-derivatives
#15
Tao Zhang, Ruyi Yang, Shengnan Yang, Jibin Guan, Dong Zhang, Yan Ma, Hongzhuo Liu
Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and 'switch-on/off' mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29333563/aldehyde-dehydrogenase-activity-in-adipose-tissue-isolation-and-gene-expression-profile-of-distinct-sub-population-of-mesenchymal-stromal-cells
#16
Mehdi Najar, Emerence Crompot, Leo A van Grunsven, Laurent Dollé, Laurence Lagneaux
Thanks to their relative abundance and easier collection, adipose tissue (AT) is considered an alternative source for the isolation of mesenchymal stromal cells (MSCs). MSCs have great therapeutic values and are thus under investigations for several clinical indications such as regenerative medicine and immunomodulation. In this work, we aimed to identify, isolate and characterize AT-MSCs based on their aldehyde dehydrogenase (ALDH) activity known to be a classical feature of stem cells. FACS technology allowed to isolate two different populations of AT-MSCs according to their ALDH activity (referred as ALDH+ and ALDH-)...
January 15, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29333491/multifunctional-bioreactor-system-for-human-intestine-tissues
#17
Wenda Zhou, Ying Chen, Terrence Roh, Yinan Lin, Shengjie Ling, Siwei Zhao, James D Lin, Noor Khalil, Dana M Cairns, Eleana Manousiouthakis, Megan Tse, David L Kaplan
The three-dimensional (3D) cultivation of intestinal cells and tissues in dynamic bioreactor systems to represent in vivo intestinal microenvironments is essential for developing regenerative medicine treatments for intestinal diseases. We have previously developed in vitro human intestinal tissue systems using a 3D porous silk scaffold system with intestinal architectures and topographical features for the adhesion, growth, and differentiation of intestinal cells under static culture conditions. In this study, we designed and fabricated a multifunctional bioreactor system that incorporates pre-epithelialized 3D silk scaffolds in a dynamic culture environment for in vitro engineering of human intestine tissues...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29333322/a-randomized-controlled-clinical-study-of-periodontal-tissue-regeneration-using-an-extracellular-matrix-based-resorbable-membrane-in-combination-with-a-collagenated-bovine-bone-graft-in-intrabony-defects
#18
Sulhee Kim, Hyeyoon Chang, Jin Wook Hwang, Sungtae Kim, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, Jong-Ho Lee, In-Chul Rhyu
Purpose: The purpose of this study was to investigate the feasibility of regenerative therapy with a collagenated bone graft and resorbable membrane in intrabony defects, and to evaluate the effects of the novel extracellular matrix (ECM)-based membrane clinically and radiologically. Methods: Periodontal tissue regeneration procedure was performed using an ECM-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects around the teeth and implants...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29333321/periodontal-wound-healing-following-reciprocal-autologous-root-transplantation-in-class-iii-furcation-defects
#19
Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi
Purpose: Furcation involvement in the molars is difficult to treat, and has been recognized as a risk factor for tooth loss. Although periodontal regenerative therapies, including guided tissue regeneration and various types of bone grafts, have been applied to furcation defects, the effects of these treatments are limited, especially in large class III furcation defects. The purpose of this pilot study was to investigate the effect of reciprocal autologous root transplantation on periodontal wound healing and regeneration in class III furcation defects in dogs...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29332841/improved-neuron-culture-using-scaffolds-made-of-three-dimensional-pdms-micro-lattices
#20
Sisi Li, Francesco Paolo Ulloa Severino, Jelena Ban, Li Wang, Giulietta Pinato, Vincent Torre, Yong Chen
Tissue engineering strives to create functional components of organs with different cell types in vitro. One of the challenges is to fabricate scaffolds for three-dimensional (3D) cell culture under physiological conditions. Of particular interesting is to investigate the morphology and function of the central nervous system (CNS) cultured using such scaffolds. Here, we used an elastomer, polydimethylsiloxane (PDMS), to produce lattice-type scaffolds from a photolithography defined template. The photomask with antidot arrays was spin-coated by a thick layer of resist and downward mounted on a rotating stage at angle of 45°...
January 15, 2018: Biomedical Materials
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