keyword
MENU ▼
Read by QxMD icon Read
search

Refinement validation structure

keyword
https://www.readbyqxmd.com/read/27917827/the-n14-anti-afamin-antibody-fab-a-rare-vl1-cdr-glycosylation-crystallographic-re-sequencing-molecular-plasticity-and-conservative-versus-enthusiastic-modelling
#1
Andreas Naschberger, Barbara G Fürnrohr, Tihana Lenac Rovis, Suzana Malic, Klaus Scheffzek, Hans Dieplinger, Bernhard Rupp
The monoclonal antibody N14 is used as a detection antibody in ELISA kits for the human glycoprotein afamin, a member of the albumin family, which has recently gained interest in the capture and stabilization of Wnt signalling proteins, and for its role in metabolic syndrome and papillary thyroid carcinoma. As a rare occurrence, the N14 Fab is N-glycosylated at Asn26L at the onset of the VL1 antigen-binding loop, with the α-1-6 core fucosylated complex glycan facing out of the L1 complementarity-determining region...
December 1, 2016: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/27911135/development-of-a-new-measurement-scale-for-interprofessional-collaborative-competency-the-chiba-interprofessional-competency-scale-cics29
#2
Ikuko Sakai, Takeshi Yamamoto, Yoshinori Takahashi, Takashi Maeda, Yuuko Kunii, Kana Kurokochi
AVSTRACT The purpose of this study was to refine the items on a scale measuring interprofessional collaborative competency that was developed by the authors in an earlier pilot study. A questionnaire-based study was conducted with a sample of 2133 health professionals using the reformulated questionnaire. Construct validity was tested by comparing the survey results with a covariance structure analysis and the domains of interprofessional collaboration competencies presented in previous studies. A second survey was conducted 2 weeks later with a sample of 571 nursing professionals, using the same survey form to test its reliability...
December 2, 2016: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/27908163/learning-based-3t-brain-mri-segmentation-with-guidance-from-7t-mri-labeling
#3
Minghui Deng, Renping Yu, Li Wang, Feng Shi, Pew-Thian Yap, Dinggang Shen
PURPOSE: Segmentation of brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is crucial for brain structural measurement and disease diagnosis. Learning-based segmentation methods depend largely on the availability of good training ground truth. However, the commonly used 3T MR images are of insufficient image quality and often exhibit poor intensity contrast between WM, GM, and CSF. Therefore, they are not ideal for providing good ground truth label data for training learning-based methods...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27895523/refinement-of-the-long-term-conditions-questionnaire-ltcq-patient-and-expert-stakeholder-opinion
#4
Laura Kelly, Caroline M Potter, Cheryl Hunter, Elizabeth Gibbons, Ray Fitzpatrick, Crispin Jenkinson, Michele Peters
PURPOSE: It is a key UK government priority to assess and improve outcomes in people with long-term conditions (LTCs). We are developing a new patient-reported outcome measure, the Long-Term Conditions Questionnaire (LTCQ), for use among people with single or multiple LTCs. This study aimed to refine candidate LTCQ items that had previously been informed through literature reviews, interviews with professional stakeholders, and interviews with people with LTCs. MATERIALS AND METHODS: Cognitive interviews (n=32) with people living with LTCs and consultations with professional stakeholders (n=13) and public representatives (n=5) were conducted to assess the suitability of 23 candidate items...
2016: Patient related Outcome Measures
https://www.readbyqxmd.com/read/27866484/exploring-dsm-5-adhd-criteria-beyond-young-adulthood-phenomenology-psychometric-properties-and-prevalence-in-a-large-three-decade-birth-cohort
#5
E S Vitola, C H D Bau, G A Salum, B L Horta, L Quevedo, F C Barros, R T Pinheiro, C Kieling, L A Rohde, E H Grevet
BACKGROUND: There are still uncertainties on the psychometric validity of the DSM-5 attention deficit hyperactivity disorder (ADHD) criteria for its use in the adult population. We aim to describe the adult ADHD phenotype, to test the psychometric properties of the DSM-5 ADHD criteria, and to calculate the resulting prevalence in a population-based sample in their thirties. METHOD: A cross-sectional evaluation using the DSM-5 ADHD criteria was carried out in 3574 individuals from the 1982 Pelotas Birth Cohort...
November 21, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27866433/rasch-validation-of-the-arabic-version-of-the-lower-extremity-functional-scale
#6
Ali H Alnahdi
PURPOSE: The purpose of this study was to examine the internal construct validity of the Arabic version of the Lower Extremity Functional Scale (20-item Arabic LEFS) using Rasch analysis. METHODS: Patients (n = 170) with lower extremity musculoskeletal dysfunction were recruited. Rasch analysis of 20-item Arabic LEFS was performed. Once the initial Rasch analysis indicated that the 20-item Arabic LEFS did not fit the Rasch model, follow-up analyses were conducted to improve the fit of the scale to the Rasch measurement model...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27857521/global-chemical-reactivity-parameters-for-several-chiral-beta-blockers-from-the-density-functional-theory-viewpoint
#7
Mona Maria Talmaciu, Ede Bodoki, Radu Oprean
BACKGROUND AND AIM: Beta-adrenergic antagonists have been established as first line treatment in the medical management of hypertension, acute coronary syndrome and other cardiovascular diseases, as well as for the prevention of initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices, glaucoma, and have recently become the main form of treatment of infantile hemangiomas. The aim of the present study is to calculate for 14 beta-blockers several quantum chemical descriptors in order to interpret various molecular properties such as electronic structure, conformation, reactivity, in the interest of determining how such descriptors could have an impact on our understanding of the experimental observations and describing various aspects of chemical binding of beta-blockers in terms of these descriptors...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27854043/psychometric-properties-of-the-obstacles-to-return-to-work-questionnaire-in-a-brazilian-context
#8
Daniela Milani, Neusa Maria Costa Alexandre, Juliana Alvares Duarte Bonini Campos, Sheilah Hogg-Johnson
Purpose To evaluate the psychometric properties of the Obstacles to Return-to-Work Questionnaire (ORTWQ) among Brazilian workers on sick-leave due to musculoskeletal disorders. Methods Confirmatory factor analysis was conducted to evaluate the factor structure validity of the ORTWQ. Model fit indices and salience of factor loadings were assessed. The convergent validity was estimated using the Average Variance Extracted (AVE) and Composite Reliability (CR). The correlational analysis was verified using the Spearman Correlation between the ORTWQ and other specific tools...
November 16, 2016: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/27819472/longitudinal-validation-of-general-and-specific-structural-features-of-personality-pathology
#9
Aidan G C Wright, Christopher J Hopwood, Andrew E Skodol, Leslie C Morey
Theorists have long argued that personality disorder (PD) is best understood in terms of general impairments shared across the disorders as well as more specific instantiations of pathology. A model based on this theoretical structure was proposed as part of the DSM-5 revision process. However, only recently has this structure been subjected to formal quantitative evaluation, with little in the way of validation efforts via external correlates or prospective longitudinal prediction. We used the Collaborative Longitudinal Study of Personality Disorders dataset to: (a) estimate structural models that parse general from specific variance in personality disorder features, (b) examine patterns of growth in general and specific features over the course of 10 years, and (c) establish concurrent and dynamic longitudinal associations in PD features and a host of external validators including basic personality traits and psychosocial functioning scales...
November 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27816515/structure-guided-design-of-a-series-of-selective-pyrrolopyrimidinone-mark-inhibitors
#10
Jason D Katz, Andrew Haidle, Kaleen K Childers, Anna A Zabierek, James P Jewell, Yongquan Hou, Michael D Altman, Alexander Szewczak, Dapeng Chen, Andreas Harsch, Mansuo Hayashi, Lee Warren, Michael Hutton, Hugh Nuthall, Hua-Poo Su, Sanjeev Munshi, Matt G Stanton, Ian W Davies, Ben Munoz, Alan Northrup
The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity. These efforts allowed for the identification of a compound with properties suitable for use as an in vitro tool compound for validation studies on MARK as a viable target for Alzheimer's disease.
October 22, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27815728/a-novel-algorithm-for-ventricular-arrhythmia-classification-using-a-fuzzy-logic-approach
#11
Nong Weixin
In the present study, it has been shown that an unnecessary implantable cardioverter-defibrillator (ICD) shock is often delivered to patients with an ambiguous ECG rhythm in the overlap zone between ventricular tachycardia (VT) and ventricular fibrillation (VF); these shocks significantly increase mortality. Therefore, accurate classification of the arrhythmia into VT, organized VF (OVF) or disorganized VF (DVF) is crucial to assist ICDs to deliver appropriate therapy. A classification algorithm using a fuzzy logic classifier was developed for accurately classifying the arrhythmias into VT, OVF or DVF...
November 4, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27813346/validation-of-a-non-conforming-monolithic-fluid-structure-interaction-method-using-phase-contrast-mri
#12
A Hessenthaler, O Röhrle, D A Nordsletten
This paper details the validation of a non-conforming arbitrary Lagrangian-Eulerian fluid-structure interaction (FSI) technique using a recently developed experimental 3D FSI benchmark problem. Numerical experiments for steady and transient test cases of the benchmark were conducted employing an inf-sup stable and a general Galerkin scheme. The performance of both schemes is assessed. Spatial refinement with three mesh refinement levels and fluid domain truncation with two fluid domain lengths are studied as well as employing a sequence of increasing time step sizes for steady-state cases...
November 4, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27788466/a-psychometric-evaluation-of-hierarchical-and-oblique-versions-of-five-variants-of-the-posttraumatic-growth-inventory
#13
Samantha C Horswill, Gabrielle Desgagné, Holly A Parkerson, R Nicholas Carleton, Gordon J G Asmundson
The Posttraumatic Growth Inventory (PTGI; Tedeschi and Calhoun, 1996) is the most commonly used measure of posttraumatic growth. Although the original five factor structure has extensive psychometric support, evidence exists for alternate PTGI models. The current study assessed the validity of oblique and hierarchical factor structures of five PTGI models. Confirmatory factor analyses were performed among a heterogeneous community sample with a diverse trauma history. The oblique models provided a better fit to the data compared with their respective hierarchical models...
October 17, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27764163/targeting-epithelial-mesenchymal-transition-for-identification-of-inhibitors-for-pancreatic-cancer-cell-invasion-and-tumor-spheres-formation
#14
Kishore Polireddy, Ruochen Dong, Peter R McDonald, Tao Wang, Brendan Luke, Ping Chen, Melinda Broward, Anuradha Roy, Qi Chen
BACKGROUND: Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that contribute to chemoresistant tumors prone to metastasis and recurrence. Drug screening assays based on cytotoxicity cannot identify specific CSC inhibitors, because CSCs comprise only a small portion of cancer cell population, and it is difficult to propagate stable CSC populations in vitro for high-throughput screening (HTS) assays. Based on the important role of cancer cell epithelial-to-mesenchymal transition (EMT) in promoting CSCs, we hypothesized that inhibition of EMT can be a useful strategy for inhibiting CSCs, and therefore a feasible approach for HTS can be built for identification of CSC inhibitors, based on assays detecting EMT inhibition...
2016: PloS One
https://www.readbyqxmd.com/read/27756456/river-blindness-mathematical-models-for-control-and-elimination
#15
M G Basáñez, M Walker, H C Turner, L E Coffeng, S J de Vlas, W A Stolk
Human onchocerciasis (river blindness) is one of the few neglected tropical diseases (NTDs) whose control strategies have been informed by mathematical modelling. With the change in focus from elimination of the disease burden to elimination of Onchocerca volvulus, much remains to be done to refine, calibrate and validate existing models. Under the impetus of the NTD Modelling Consortium, the teams that developed EPIONCHO and ONCHOSIM have joined forces to compare and improve these frameworks to better assist ongoing elimination efforts...
2016: Advances in Parasitology
https://www.readbyqxmd.com/read/27748625/machine-learning-approaches-for-predicting-protein-complex-similarity
#16
Roshanak Farhoodi, Bahar Akbal-Delibas, Nurit Haspel
Discriminating native-like structures from false positives with high accuracy is one of the biggest challenges in protein-protein docking. While there is an agreement on the existence of a relationship between various favorable intermolecular interactions (e.g., Van der Waals, electrostatic, and desolvation forces) and the similarity of a conformation to its native structure, the precise nature of this relationship is not known. Existing protein-protein docking methods typically formulate this relationship as a weighted sum of selected terms and calibrate their weights by using a training set to evaluate and rank candidate complexes...
October 17, 2016: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/27722721/structure-determination-of-ba5alf13-by-coupling-electron-synchrotron-and-neutron-powder-diffraction-solid-state-nmr-and-ab-initio-calculations
#17
Charlotte Martineau, Mathieu Allix, Matthew R Suchomel, Florence Porcher, François Vivet, Christophe Legein, Monique Body, Dominique Massiot, Francis Taulelle, Franck Fayon
The room temperature structure of Ba5AlF13 has been investigated by coupling electron, synchrotron and neutron powder diffraction, solid-state high-resolution NMR ((19)F and (27)Al) and first principles calculations. An initial structural model has been obtained from electron and synchrotron powder diffraction data, and its main features have been confirmed by one- and two-dimensional NMR measurements. However, DFT GIPAW calculations of the (19)F isotropic shieldings revealed an inaccurate location of one fluorine site (F3, site 8a), which exhibited unusual long F-Ba distances...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27715477/translation-and-validation-of-the-chinese-versions-of-the-suicidal-ideation-attributes-scale-stigma-of-suicide-scale-and-literacy-of-suicide-scale
#18
Jin Han, Philip J Batterham, Alison L Calear, Yang Wu, Yiyun Shou, Bregje A J van Spijker
This paper reports the validation of the Chinese versions of the Suicidal Ideation Attributes Scale (SIDAS), Stigma of Suicide Scale (short form, SOSS), and Literacy of Suicide Scale (short form, LOSS) among 57 Chinese and English bilinguals and 224 Chinese university students. All the translated scales showed high correlations with the original versions. The translated SIDAS and refined SOSS demonstrated robust factor structures, good internal consistency and convergent validity. Chinese students with self-reported depression symptoms tended to have higher glorification of suicide and lower suicide literacy...
August 11, 2016: Death Studies
https://www.readbyqxmd.com/read/27713905/a-harmonized-data-quality-assessment-terminology-and-framework-for-the-secondary-use-of-electronic-health-record-data
#19
Michael G Kahn, Tiffany J Callahan, Juliana Barnard, Alan E Bauck, Jeff Brown, Bruce N Davidson, Hossein Estiri, Carsten Goerg, Erin Holve, Steven G Johnson, Siaw-Teng Liaw, Marianne Hamilton-Lopez, Daniella Meeker, Toan C Ong, Patrick Ryan, Ning Shang, Nicole G Weiskopf, Chunhua Weng, Meredith N Zozus, Lisa Schilling
OBJECTIVE: Harmonized data quality (DQ) assessment terms, methods, and reporting practices can establish a common understanding of the strengths and limitations of electronic health record (EHR) data for operational analytics, quality improvement, and research. Existing published DQ terms were harmonized to a comprehensive unified terminology with definitions and examples and organized into a conceptual framework to support a common approach to defining whether EHR data is 'fit' for specific uses...
2016: EGEMS
https://www.readbyqxmd.com/read/27710932/validation-and-correction-of-zn-cysxhisy-complexes
#20
Wouter G Touw, Bart van Beusekom, Jochem M G Evers, Gert Vriend, Robbie P Joosten
Many crystal structures in the Protein Data Bank contain zinc ions in a geometrically distorted tetrahedral complex with four Cys and/or His ligands. A method is presented to automatically validate and correct these zinc complexes. Analysis of the corrected zinc complexes shows that the average Zn-Cys distances and Cys-Zn-Cys angles are a function of the number of cysteines and histidines involved. The observed trends can be used to develop more context-sensitive targets for model validation and refinement.
October 1, 2016: Acta Crystallographica. Section D, Structural Biology
keyword
keyword
64670
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"