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https://www.readbyqxmd.com/read/28231266/an-examination-of-the-factorial-and-convergent-validity-of-four-measures-of-conspiracist-ideation-with-recommendations-for-researchers
#1
Viren Swami, David Barron, Laura Weis, Martin Voracek, Stefan Stieger, Adrian Furnham
A number scales have been developed to measure conspiracist ideation, but little attention has been paid to the factorial validity of these scales. We reassessed the psychometric properties of four widely-used scales, namely the Belief in Conspiracy Theories Inventory (BCTI), the Conspiracy Mentality Questionnaire (CMQ), the Generic Conspiracist Beliefs Scale (GCBS), and the One-Item Conspiracy Measure (OICM). Eight-hundred-and-three U.S. adults completed all measures, along with measures of endorsement of 9/11 and anti-vaccination conspiracy theories...
2017: PloS One
https://www.readbyqxmd.com/read/28223945/toward-respiratory-assessment-using-depth-measurements-from-a-time-of-flight-sensor
#2
Charles Sharp, Vahid Soleimani, Sion Hannuna, Massimo Camplani, Dima Damen, Jason Viner, Majid Mirmehdi, James W Dodd
Introduction: There is increasing interest in technologies that may enable remote monitoring of respiratory disease. Traditional methods for assessing respiratory function such as spirometry can be expensive and require specialist training to perform and interpret. Remote, non-contact tracking of chest wall movement has been explored in the past using structured light, accelerometers and impedance pneumography, but these have often been costly and clinical utility remains to be defined. We present data from a 3-Dimensional time-of-flight camera (found in gaming consoles) used to estimate chest volume during routine spirometry maneuvres...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28210925/prospective-associations-between-depressive-symptoms-and-the-metabolic-syndrome-the-spirited-life-study-of-methodist-pastors-in-north-carolina
#3
Timothy W Smith, David E Eagle, Rae Jean Proeschold-Bell
BACKGROUND: Metabolic syndrome (Met-S) has a robust concurrent association with depression. A small, methodologically limited literature suggests that Met-S and depression are reciprocally related over time, an association that could contribute to their overlapping influences on morbidity and mortality in cardiovascular disease, diabetes, and cancer. PURPOSE: Using a refined approach to the measurement of Met-S as a continuous latent variable comprising continuous components, this study tested the prospective associations between Met-S and depression...
February 16, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28198721/the-chronic-otitis-media-benefit-inventory-combi-development-and-validation-of-a-dynamic-quality-of-life-questionnaire-for-chronic-ear-disease
#4
John S Phillips, Mark Haggard, Helen Spencer, Matthew Yung
OBJECTIVE: This study introduces a change-oriented short-form health-related quality of life questionnaire suited to symptoms of adult chronic middle ear disease and its consequences, and describes its properties. STUDY DESIGN: Two-centre prospective correlational study primarily for instrument development. SETTING: Two otology secondary care centers in England. PATIENTS: Fifty-two consecutive adult patients with active chronic otitis media undergoing surgery...
February 14, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28198676/global-transcriptome-analysis-reveals-extensive-gene-remodeling-alternative-splicing-and-differential-transcription-profiles-in-non-seed-vascular-plant-selaginella-moellendorffii
#5
Yan Zhu, Longxian Chen, Chengjun Zhang, Pei Hao, Xinyun Jing, Xuan Li
BACKGROUND: Selaginella moellendorffii, a lycophyte, is a model plant to study the early evolution and development of vascular plants. As the first and only sequenced lycophyte to date, the genome of S. moellendorffii revealed many conserved genes and pathways, as well as specialized genes different from flowering plants. Despite the progress made, little is known about long noncoding RNAs (lncRNA) and the alternative splicing (AS) of coding genes in S. moellendorffii. Its coding gene models have not been fully validated with transcriptome data...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28197927/thermodynamics-and-reaction-mechanisms-of-decomposition-of-the-simplest-protonated-tripeptide-triglycine-a-guided-ion-beam-and-computational-study
#6
Abhigya Mookherjee, Michael J Van Stipdonk, P B Armentrout
We present a thorough characterization of fragmentations observed in threshold collision-induced dissociation (TCID) experiments of protonated triglycine (H(+)GGG) with Xe using a guided ion beam tandem mass spectrometer (GIBMS). Kinetic energy-dependent cross-sections for 10 ionic products are observed and analyzed to provide 0 K barriers for six primary products: [b2](+), [y1 + 2H](+), [b3](+), CO loss, [y2 + 2H](+), and [a1](+); three secondary products: [a2](+), [a3](+), and [y2 + 2H - CO](+); and two tertiary products: high energy [y1 + 2H](+) and [a2 - CO](+) after accounting for multiple ion-molecule collisions, internal energy of reactant ions, unimolecular decay rates, competition between channels, and sequential dissociations...
February 14, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28194462/designing-an-efficient-multi-epitope-oral-vaccine-against-helicobacter-pylori-using-immunoinformatics-and-structural-vaccinology-approaches
#7
Navid Nezafat, Mahboobeh Eslami, Manica Negahdaripour, Mohammad Reza Rahbar, Younes Ghasemi
Helicobacter pylori is the cunning bacterium that can live in the stomachs of many people without any symptoms, but gradually can lead to gastric cancer. Due to various obstacles, which are related to anti-H. pylori antibiotic therapy, recently developing an anti-H. pylori vaccine has attracted more attention. In this study, different immunoinformatics and computational vaccinology approaches were employed to design an efficient multi-epitope oral vaccine against H. pylori. Our multi-epitope vaccine is composed of heat labile enterotoxin IIc B (LT-IIc) that is used as a mucosal adjuvant to enhance vaccine immunogenicity for oral immunization, cartilage oligomeric matrix protein (COMP) to increase vaccine stability in acidic pH of gut, one experimentally protective antigen, OipA, and two hypothetical protective antigens, HP0487 and HP0906, and "CTGKSC" peptide motif that target epithelial microfold cells (M cells) to enhance vaccine uptake from the gut barrier...
February 14, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28183813/targeted-proteomics-and-absolute-protein-quantification-for-the-construction-of-a-stoichiometric-host-pathogen-surface-density-model
#8
Kristoffer Sjöholm, Ola Kilsgård, Johan Teleman, Lotta Happonen, Lars Malmström, Johan Malmström
Sepsis is a systemic immune response responsible for considerable morbidity and mortality. Molecular modelling of host-pathogen interactions in the disease state represents a promising strategy to define molecular events of importance for the transition from superficial to invasive infectious diseases. Here we used the gram-positive bacterium Streptococcus pyogenes as a model system to establish a mass spectrometry based workflow for the construction of a stoichiometric surface density model between the S. pyogenes surface, the surface virulence factor M-protein, and adhered human blood plasma proteins...
February 9, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28178177/wideband-direction-of-arrival-estimation-in-the-presence-of-unknown-mutual-coupling
#9
Weixing Li, Yue Zhang, Jianzhi Lin, Rui Guo, Zengping Chen
This paper investigates a subarray based algorithm for direction of arrival (DOA) estimation of wideband uniform linear array (ULA), under the presence of frequency-dependent mutual coupling effects. Based on the Toeplitz structure of mutual coupling matrices, the whole array is divided into the middle subarray and the auxiliary subarray. Then two-sided correlation transformation is applied to the correlation matrix of the middle subarray instead of the whole array. In this way, the mutual coupling effects can be eliminated...
February 6, 2017: Sensors
https://www.readbyqxmd.com/read/28177313/strategies-for-carbohydrate-model-building-refinement-and-validation
#10
Jon Agirre
Sugars are the most stereochemically intricate family of biomolecules and present substantial challenges to anyone trying to understand their nomenclature, reactions or branched structures. Current crystallographic programs provide an abstraction layer allowing inexpert structural biologists to build complete protein or nucleic acid model components automatically either from scratch or with little manual intervention. This is, however, still not generally true for sugars. The need for carbohydrate-specific building and validation tools has been highlighted a number of times in the past, concomitantly with the introduction of a new generation of experimental methods that have been ramping up the production of protein-sugar complexes and glycoproteins for the past decade...
February 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28177312/ligand-fitting-with-ccp4
#11
Robert A Nicholls
Crystal structures of protein-ligand complexes are often used to infer biology and inform structure-based drug discovery. Hence, it is important to build accurate, reliable models of ligands that give confidence in the interpretation of the respective protein-ligand complex. This paper discusses key stages in the ligand-fitting process, including ligand binding-site identification, ligand description and conformer generation, ligand fitting, refinement and subsequent validation. The CCP4 suite contains a number of software tools that facilitate this task: AceDRG for the creation of ligand descriptions and conformers, Lidia and JLigand for two-dimensional and three-dimensional ligand editing and visual analysis, Coot for density interpretation, ligand fitting, analysis and validation, and REFMAC5 for macromolecular refinement...
February 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28177311/polder-maps-improving-omit-maps-by-excluding-bulk-solvent
#12
Dorothee Liebschner, Pavel V Afonine, Nigel W Moriarty, Billy K Poon, Oleg V Sobolev, Thomas C Terwilliger, Paul D Adams
The crystallographic maps that are routinely used during the structure-solution workflow are almost always model-biased because model information is used for their calculation. As these maps are also used to validate the atomic models that result from model building and refinement, this constitutes an immediate problem: anything added to the model will manifest itself in the map and thus hinder the validation. OMIT maps are a common tool to verify the presence of atoms in the model. The simplest way to compute an OMIT map is to exclude the atoms in question from the structure, update the corresponding structure factors and compute a residual map...
February 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28177306/validation-and-extraction-of-molecular-geometry-information-from-small-molecule-databases
#13
Fei Long, Robert A Nicholls, Paul Emsley, Saulius Graǽulis, Andrius Merkys, Antanas Vaitkus, Garib N Murshudov
A freely available small-molecule structure database, the Crystallography Open Database (COD), is used for the extraction of molecular-geometry information on small-molecule compounds. The results are used for the generation of new ligand descriptions, which are subsequently used by macromolecular model-building and structure-refinement software. To increase the reliability of the derived data, and therefore the new ligand descriptions, the entries from this database were subjected to very strict validation...
February 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28167161/structure-determination-of-contaminant-proteins-using-the-marathonmr-procedure
#14
Kaushik Hatti, Ansuman Biswas, Santosh Chaudhary, Venkatareddy Dadireddy, Kanagaraj Sekar, Narayanaswamy Srinivasan, Mathur R N Murthy
In the recent decades, essential steps of protein structure determination such as phasing by multiple isomorphous replacement and multi wave length anomalous dispersion, molecular replacement, refinement of the structure determined and its validation have been fully automated. Several computer program suites that execute all these steps as a pipeline operation have been made available. In spite of these great advances, determination of a protein structure may turn out to be a challenging task for a variety of reasons...
February 3, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28160722/molecular-modeling-simulation-and-docking-study-of-ebola-virus-glycoprotein
#15
Nasir Ahmad, Aqsa Farman, Syed Lal Badshah, Ata Ur Rahman, Haroon Ur Rashid, Khalid Khan
Ebola virus (EBOV) is a filamentous, enveloped, non-segmented, negative-strand ribonucleic acid (RNA) virus which belongs to family Filoviridae. Ebola virus includes different glycoproteins each of which plays their roles in different aspects of viral life cycle. In this study secreted glycoprotein (Q7T9E0) of Ebola virus was acquired from Uniprot. The formation of alpha helix and beta sheets of secondary structures were predicted through online servers. Higher flexibility and disordered regions of proteins were determined through RONN, GLOBPLOT and DISSEMBLE...
December 19, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28135086/thienopyrimidinone-based-sirtuin-2-sirt2-selective-inhibitors-bind-in-the-ligand-induced-selectivity-pocket
#16
Sandeep Sundriyal, Sébastien Moniot, Zimam Mahmud, Shang Yao, Paolo Di Fruscia, Christopher R Reynolds, David T Dexter, Michael J E Sternberg, Eric W-F Lam, Clemens Steegborn, Matthew J Fuchter
Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets for further validation. Previously, we reported a novel thienopyrimidinone SIRT2 inhibitor with good potency and excellent selectivity for SIRT2. Herein, we report an extensive SAR study of this chemical series and identify the key pharmacophoric elements and physiochemical properties that underpin the excellent activity observed. New analogues have been identified with submicromolar SIRT2 inhibtory activity and good to excellent SIRT2 subtype-selectivity...
February 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28132611/stakeholder-conceptualisation-of-multi-level-hiv-and-aids-determinants-in-a-black-epicentre
#17
Bridgette M Brawner, Janaiya L Reason, Kelsey Hanlon, Barbara Guthrie, Jean J Schensul
HIV has reached epidemic proportions among African Americans in the USA but certain urban contexts appear to experience a disproportionate disease burden. Geographic information systems mapping in Philadelphia indicates increased HIV incidence and prevalence in predominantly Black census tracts, with major differences across adjacent communities. What factors shape these geographic HIV disparities among Black Philadelphians? This descriptive study was designed to refine and validate a conceptual model developed to better understand multi-level determinants of HIV-related risk among Black Philadelphians...
January 30, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28130235/ispred4-interaction-sites-prediction-in-protein-structures-with-a-refining-grammar-model
#18
Castrense Savojardo, Piero Fariselli, Pier Luigi Martelli, Rita Casadio
MOTIVATION: The identification of Protein-Protein Interaction (PPI) sites is an important step towards the characterization of protein functional integration in the cell complexity. Experimental methods are costly and time-consuming and computational tools for predicting PPI sites can fill the gaps of PPI present knowledge. RESULTS: We present ISPRED4, an improved structure-based predictor of PPI sites on unbound monomer surfaces. ISPRED4 relies on machine-learning methods and incorporating features extracted from protein sequence and structure...
January 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28114008/3d-catheter-shape-determination-for-endovascular-navigation-using-a-two-step-particle-filter-and-ultrasound-scanning
#19
Fang Chen, Jia Liu, Hongen Liao
In endovascular catheter interventions, the determination of the three-dimensional (3D) catheter shape can increase navigation information and help reduce trauma. This study describes a shape determination method for a flexible interventional catheter using ultrasound scanning and a two-step particle filter without X-ray fluoroscopy. First, we propose a multi-feature, multi-template particle filter algorithm for accurate catheter tracking from ultrasound images. Second, we model the mechanical behavior of the catheter and apply a particle filter shape optimization algorithm to refine the results from the first step...
December 5, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28112646/the-ostomy-q-development-and-psychometric-validation-of-an-instrument-to-evaluate-outcomes-associated-with-ostomy-appliances
#20
Beenish Nafees, Mikkel Rasmussen, Andrew LLoyd
Using an ostomy appliance can affect many aspects of a person's health-related quality of life (HRQL). A 2-part, descrip- tive study was designed to develop and validate an instrument to assess quality-of-life outcomes related to ostomy ap- pliance use. Study inclusion/exclusion criteria stipulated participants should be 18 to 85 years of age, have an ileostomy or colostomy, used an appliance for a minimum of 3 months without assistance, and able to complete an online survey. All participants provided sociodemographic and clinical information...
January 2017: Ostomy/wound Management
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