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https://www.readbyqxmd.com/read/28650514/automatic-segmentation-of-the-spine-by-means-of-a-probabilistic-atlas-with-a-special-focus-on-ribs-suppression
#1
Silvia Ruiz-España, Juan Domingo, Antonio Díaz-Parra, Esther Dura, Víctor D'Ocón-Alcañiz, Estanislao Arana, David Moratal
PURPOSE: The development of automatic and reliable algorithms for the detection and segmentation of the vertebrae are of great importance prior to any diagnostic task. However, an important problem found to accurately segment the vertebrae is the presence of the ribs in the thoracic region. To overcome this problem, a probabilistic atlas of the spine has been developed dealing with the proximity of other structures, with a special focus on ribs suppression. METHODS: The data sets used consist of Computed Tomography images corresponding to 21 patients suffering from spinal metastases...
June 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28649312/the-eu-aims-longitudinal-european-autism-project-leap-design-and-methodologies-to-identify-and-validate-stratification-biomarkers-for-autism-spectrum-disorders
#2
Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily J H Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis, Sven Bölte, Thomas Bourgeron, Carsten Bours, Yvette de Bruijn, Bhismadev Chakrabarti, Daisy Crawley, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Hannah Hayward, Lindsay M Ham, Joerg Hipp, Rosemary J Holt, Mark H Johnson, Johan Isaksson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Amber N V Ruigrok, Barbara Ruggeri, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve C R Williams, Marcel P Zwiers, Will Spooren, Declan G M Murphy, Jan K Buitelaar
BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28643117/children-s-family-experiences-development-of-the-promis-%C3%A2-pediatric-family-relationships-measures
#3
Katherine B Bevans, Anne W Riley, Jeanne M Landgraf, Adam C Carle, Rachel E Teneralli, Barbara H Fiese, Lisa J Meltzer, Anna K Ettinger, Brandon D Becker, Christopher B Forrest
PURPOSE: To describe the development of pediatric family relationships measures, with versions for child self-report (8-17 years) and parent-report for children 5-17 years old. Measures were created for integration into the Patient Reported Outcomes Measurement Information System (PROMIS(®)). METHODS: Semi-structured interviews with 10 experts, 24 children, and 8 parents were conducted to elicit and clarify essential elements of family relationships. A systematic literature review was conducted to identify item concepts representative of each element...
June 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28636001/wataa-atlas-of-protein-hydration-exploring-synergies-between-data-mining-and-ab-initio-calculations
#4
Jiří Černý, Bohdan Schneider, Lada Biedermannová
Water molecules represent an integral part of proteins and a key determinant of protein structure, dynamics and function. WatAA is a newly developed, web-based atlas of amino-acid hydration in proteins. The atlas provides information about the ordered first hydration shell of the most populated amino-acid conformers in proteins. The data presented in the atlas are drawn from two sources: experimental data and ab initio quantum-mechanics calculations. The experimental part is based on a data-mining study of a large set of high-resolution protein crystal structures...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28631978/structural-and-predictive-properties-of-the-emotional-quotient-inventory-youth-version-short-form-eq-i-yv-s
#5
Sarah K Davis, Michael Wigelsworth
Emotional intelligence (EI) is a popular construct with concentrated areas of application in education and health contexts. There is a need for reliable and valid measurement of EI in young people, with brief yet sensitive measures of the construct preferable for use in time-limited settings. However, the proliferation of EI measures has often outpaced rigorous psychometric evaluation (Gignac, 2009 ). Using data from 849 adolescents (407 females, 422 males) aged 11 to 16 years (M age 13.4, SD = 1.2 years), this article systematically examines the structural and predictive properties of a frequently employed measure of adolescent trait EI-the Emotional Quotient Inventory Youth Version-Short Form (EQ-i:YV[S]); Bar-On & Parker, 2000 )...
March 2, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28623735/biochemical-and-structural-characterization-of-penicillium-purpurogenum-%C3%AE-d-galactosidase-binding-of-galactose-to-an-alternative-pocket-may-explain-enzyme-inhibition
#6
Luis Morales-Quintana, Carolina Faúndez, Raúl Herrera, Vasni Zavaleta, María Cristina Ravanal, Jaime Eyzaguirre, María Alejandra Moya-León
The fungus Penicillium purpurogenum degrades plant cell walls by the action of cellulolytic, xylanolytic and pectinolytic enzymes. The α-D-galactosidase is one of the enzymes which may act on pectin degradation. This enzyme has several biotechnological and medical applications. The aim of this work was to better understand the molecular mechanism of α-D-galactosidase from P. purpurogenum (GALP1). For this purpose, a gene coding for the enzyme was identified from the fungal genome and heterologously expressed in Pichia pastoris...
June 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28620331/vida1-the-development-and-validation-of-a-new-questionnaire-for-measuring-health-related-quality-of-life-in-patients-with-type-1-diabetes
#7
Dácil Alvarado-Martel, M Angeles Ruiz Fernández, Maribel Cuadrado Vigaray, Armando Carrillo, Mauro Boronat, Ana Expósito Montesdeoca, Lía Nattero Chávez, Maite Pozuelo Sánchez, Pino López Quevedo, Ana D Santana Suárez, Natalia Hillman, David Subias, Pilar Martin Vaquero, Lourdes Sáez de Ibarra, Didac Mauricio, Pedro de Pablos-Velasco, Francisco J Nóvoa, Ana M Wägner
This study describes the development of a new questionnaire to measure health-related quality of life (HRQoL) in patients with type 1 diabetes (the ViDa1 questionnaire) and provides information on its psychometric properties. For its development, open interviews with patients took place and topics relevant to patients' HRQoL were identified and items were generated. Qualitative analysis of items, expert review, and refinement of the questionnaire followed. A pilot study (N = 150) was conducted to explore the underlying structure of the 40-item ViDa1 questionnaire...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28618899/development-of-a-caregiver-reported-measure-to-support-systematic-assessment-of-people-with-dementia-in-long-term-care-the-integrated-palliative-care-outcome-scale-for-dementia
#8
Clare Ellis-Smith, Catherine J Evans, Fliss Em Murtagh, Lesley A Henson, Alice M Firth, Irene J Higginson, Barbara A Daveson
BACKGROUND: Symptom burden is common for long-term care residents with dementia which if untreated compromises quality of life. Measurement tools can support assessment of symptoms and problems but are not widely used in long-term care settings. We developed the Integrated Palliative care Outcome Scale for Dementia derived from the Palliative care Outcome Scale, Palliative care Outcome Scale-Symptom and Integrated Palliative care Outcome Scale. AIM: To examine the content validity, acceptability and comprehension of Integrated Palliative care Outcome Scale for Dementia for routine use in long-term care settings for people with dementia and to refine Integrated Palliative care Outcome Scale for Dementia...
July 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28614845/a-music-related-quality-of-life-measure-to-guide-music-rehabilitation-for-adult-cochlear-implant-users
#9
Giorgos Dritsakis, Rachel M van Besouw, Pádraig Kitterick, Carl A Verschuur
Purpose: A music-related quality of life (MuRQoL) questionnaire was developed for the evaluation of music rehabilitation for adult cochlear implant (CI) users. The present studies were aimed at refinement and validation. Method: Twenty-four experts reviewed the MuRQoL items for face validity. A refined version was completed by 147 adult CI users, and psychometric techniques were used for item selection, assessment of reliability, and definition of the factor structure...
June 15, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28605994/structure-based-screening-and-molecular-dynamics-simulations-offer-novel-natural-compounds-as-potential-inhibitors-of-mycobacterium-tuberculosis-isocitrate-lyase
#10
Rohit Shukla, Harish Shukla, Amit Sonkar, Tripti Pandey, Timir Tripathi
Mycobacterium tuberculosis is the etiological agent of tuberculosis in humans and is responsible for more than two million deaths annually. M. tuberculosis isocitrate lyase (MtbICL) catalyzes the first step in the glyoxylate cycle, plays a pivotal role in the persistence of M. tuberculosis, which acts as a potential target for an anti-tubercular drug. To identify the potential anti-tuberculosis compound, we conducted a structure-based virtual screening of natural compounds from the ZINC database (n = 1,67,748) against the MtbICL structure...
June 12, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28603792/regression-guided-deformable-models-for-segmentation-of-multiple-brain-rois
#11
Zhengwang Wu, Sang Hyun Park, Yanrong Guo, Yaozong Gao, Dinggang Shen
This paper proposes a novel method of using regression-guided deformable models for brain regions of interest (ROIs) segmentation. Different from conventional deformable segmentation, which often deforms shape model locally and thus sensitive to initialization, we propose to learn a regressor to explicitly guide the shape deformation, thus eventually improves the performance of ROI segmentation. The regressor is learned via two steps, (1) a joint classification and regression random forest (CRRF) and (2) an auto-context model...
October 2016: Machine Learning in Medical Imaging
https://www.readbyqxmd.com/read/28594549/playmolecule-proteinprepare-a-web-application-for-protein-preparation-for-molecular-dynamics-simulations
#12
Gerard Martinez-Rosell, Toni Giorgino, Gianni De Fabritiis
Protein preparation is a critical step in molecular simulations consisting in refining a protein PDB structure by assigning titration states and optimizing the hydrogen bonding network. In this application note, we describe ProteinPrepare, a web application designed to interactively support the preparation of protein structures. Users can upload a PDB file, choose the solvent pH value, and inspect the resulting protonated residues and H-bonding network within a 3D web interface. Protonation states are suggested automatically, but can be manually changed using the visual aid of the hydrogen bond network...
June 8, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28586627/validation-of-a-syndromic-case-definition-for-detecting-emergency-department-visits-potentially-related-to-marijuana
#13
Kathryn DeYoung, Yushiuan Chen, Robert Beum, Michele Askenazi, Cali Zimmerman, Arthur J Davidson
OBJECTIVES: Reliable methods are needed to monitor the public health impact of changing laws and perceptions about marijuana. Structured and free-text emergency department (ED) visit data offer an opportunity to monitor the impact of these changes in near-real time. Our objectives were to (1) generate and validate a syndromic case definition for ED visits potentially related to marijuana and (2) describe a method for doing so that was less resource intensive than traditional methods. METHODS: We developed a syndromic case definition for ED visits potentially related to marijuana, applied it to BioSense 2...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28573588/structure-refinement-at-atomic-resolution
#14
Mariusz Jaskolski
X-Ray diffraction data at atomic resolution, i.e., beyond 1.2 Å, provide the most detailed and reliable information we have about the structure of macromolecules, which is especially important for validating new discoveries and resolving subtle issues of molecular mechanisms. Refinement at atomic resolution allows reliable interpretation of static disorder and solvent structure, as well as modeling of anisotropic atomic vibrations and even of H atoms. Stereochemical restraints can be relaxed or removed, providing unbiased information about macromolecular stereochemistry, which in turn can be used to define improved conformation-dependent libraries, and the surplus of data allows estimation of least-squares uncertainties in the derived parameters...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28573261/development-of-oral-health-impacts-on-daily-living-questionnaire-items-a-qualitative-study
#15
Jian Liu, May Chun Mei Wong, Edward Chin Man Lo
OBJECTIVE: To develop an instrument to measure Oral Health-related Quality of Life (OHQoL) and the changes after dental treatment among older adults in Hong Kong, in order to understand their views on the influences of oral health problems and generate relevant items to design the instrument. METHODS: A qualitative study was conducted among adults aged 55 and over. Information on their perceived oral health impacts was collected during semi-structured interviews...
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/28566514/modelling-human-skull-growth-a-validated-computational-model
#16
Joseph Libby, Arsalan Marghoub, David Johnson, Roman H Khonsari, Michael J Fagan, Mehran Moazen
During the first year of life, the brain grows rapidly and the neurocranium increases to about 65% of its adult size. Our understanding of the relationship between the biomechanical forces, especially from the growing brain, the craniofacial soft tissue structures and the individual bone plates of the skull vault is still limited. This basic knowledge could help in the future planning of craniofacial surgical operations. The aim of this study was to develop a validated computational model of skull growth, based on the finite-element (FE) method, to help understand the biomechanics of skull growth...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28543724/predicting-binding-modes-of-reversible-peptide-based-inhibitors-of-falcipain-2-consistent-with-structure-activity-relationships
#17
Jorge Enrique Hernández González, Lilian Hernández Alvarez, Pedro Geraldo Pascutti, Pedro Alberto Valiente
Falcipain-2 (FP-2) is a major hemoglobinase of Plasmodium falciparum, considered an important drug target for the development of antimalarials. A previous study reported a novel series of twenty reversible peptide-based inhibitors of FP-2. However, the lack of tridimensional structures of the complexes hinders further optimization strategies to enhance the inhibitory activity of the compounds. Here we report the prediction of the binding modes of the aforementioned inhibitors to FP-2. A computational approach combining previous knowledge on the determinants of binding to the enzyme, docking and post-docking refinement steps, is employed...
May 24, 2017: Proteins
https://www.readbyqxmd.com/read/28526816/delineation-of-b-cell-epitopes-of-salmonella-enterica-serovar-typhi-hemolysin-e-potential-antibody-therapeutic-target
#18
Chai Fung Chin, Jing Yi Lai, Yee Siew Choong, Amy Amilda Anthony, Asma Ismail, Theam Soon Lim
Hemolysin E (HlyE) is an immunogenic novel pore-forming toxin involved in the pathogenesis of typhoid fever. Thus, mapping of B-cell epitopes of Salmonella enterica serovar Typhi (S. Typhi) is critical to identify key immunogenic regions of HlyE. A random 20-mer peptide library was used for biopanning with enriched anti-HlyE polyclonal antibodies from typhoid patient sera. Bioinformatic tools were used to refine, analyze and map the enriched peptide sequences against the protein to identify the epitopes. The analysis identified both linear and conformational epitopes on the HlyE protein...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526212/3d-deeply-supervised-network-for-automated-segmentation-of-volumetric-medical-images
#19
Qi Dou, Lequan Yu, Hao Chen, Yueming Jin, Xin Yang, Jing Qin, Pheng-Ann Heng
While deep convolutional neural networks (CNNs) have achieved remarkable success in 2D medical image segmentation, it is still a difficult task for CNNs to segment important organs or structures from 3D medical images owing to several mutually affected challenges, including the complicated anatomical environments in volumetric images, optimization difficulties of 3D networks and inadequacy of training samples. In this paper, we present a novel and efficient 3D fully convolutional network equipped with a 3D deep supervision mechanism to comprehensively address these challenges; we call it 3D DSN...
May 8, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28502266/refining-the-frommelt-attitude-toward-the-care-of-the-dying-scale-fatcod-b-for-medical-students-a-confirmatory-factor-analysis-and-rasch-validation-study
#20
Barbara Loera, Giorgia Molinengo, Marco Miniotti, Paolo Leombruni
OBJECTIVE: Given the increasing number of patients requiring palliative care and the need for more professionals who are able to provide care for the dying comfortably, assessment of medical attitudes toward end-of-life care is becoming a key aspect of medical education. The present study aimed to establish whether the Frommelt Attitude Toward the Care Of the Dying, Form B (FATCOD-B) meets current psychometric standards of validity for an assessment tool in medical education. METHOD: The participants were 200 undergraduate medical students...
May 15, 2017: Palliative & Supportive Care
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