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JOURNAL ARTICLE
Ehab Hanafy Shaker, Mamdouh Mahmoud Elshal, Reham Mohamed Gamal, Norma Osama Abdallah Zayed, Samuel Fayez Samy, Raafat M Reyad, Mohammed H Shaaban, Abd Alrahman M Abd Alrahman, Ahmed Salah Abdelgalil
INTRODUCTION: Postthoracotomy pain (PTP) is a severe pain complicating thoracic surgeries and its good management decreases the risk of PTP syndrome (PTPS). OBJECTIVES: This randomized controlled study evaluated the efficacy of ultrasound-guided continuous erector spinae plane block (ESPB) with or without dexmedetomidine compared with thoracic epidural analgesia (TEA) in managing acute postoperative pain and the possible emergence of PTPS. METHODS: Ninety patients with chest malignancies planned for thoracotomy were randomly allocated into 3 equal groups...
December 2023: Pain Reports
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JOURNAL ARTICLE
Sara Al-Khawaga, Wasim Akram, Khairunnisa Hussain, Mani Chandran, Joerg Buddenkotte, Febu Elizabeth Joy, Sena Manjooran, Basheer Kolaparambath, Hala Mosaad, Khalifa Al-Naama, Hanadi Al Hamad, Martin Steinhoff
Background: The 'GeriDerm' (geriatric dermatology) clinic, is a new dermatology-based service at Hamad Medical Corporation (HMC), accommodating the needs of our elderly population living in the State of Qatar. Due to the global demographic transition towards an elderly population (≥65 years of age), incidences of chronic diseases, including dermatologic conditions, rise in parallel. Patients of older age are at higher risk of using multiple medications, seeing multiple care providers, often receiving multiple diverging pieces of information, and feeling lost within the system...
2023: Qatar Medical Journal
#23
JOURNAL ARTICLE
Feng Luo, Xue-Mei Yuan, Hong Xiong, Chang-Ming Chen, Wu-Kai Ma, Xue-Ming Yao
RATIONALE: Acute generalized exanthematous pustulosis (AGEP) is a serious adverse skin reaction characterized by the rapid appearance of densely distributed, small, sterile pustules with erythema. However, its pathogenesis is not fully understood. Hydroxychloroquine is widely used for the treatment of autoimmune diseases. Some patients presenting with AGEP have IL36RN and CARD14 gene mutations. Our report describes a patient with rheumatoid arthritis and AGEP associated with hydroxychloroquine and a newly discovered CARD14 gene mutation...
November 24, 2023: Medicine (Baltimore)
#24
JOURNAL ARTICLE
Hakan Ozer, Yasin Ozturk, Fethi Yonet, Ismail Baloglu, Kultigin Turkmen, Nedim Yılmaz Selcuk, Halil Zeki Tonbul
INTRODUCTION: This study investigated the relationship between ultrafiltration (UF) volume and pruritus severity based on the idea that skin perfusion and inflammatory changes occur in dialysis patients with high UF volume. MATERIALS AND METHODS: This observational study included 392 patients. Patients filled out the Numerical Rating Scale, Verbal Rating Scale, and Visual Analogue Scale, showing the severity of pruritis. UF volumes in the last 12 sessions were recorded and averaged...
November 22, 2023: Therapeutic Apheresis and Dialysis
#25
MULTICENTER STUDY
Jimmy L Zhao, Emmanuel S Antonarakis, Heather H Cheng, Daniel J George, Rahul Aggarwal, Elyn Riedel, Takayuki Sumiyoshi, Joseph D Schonhoft, Amanda Anderson, Ninghui Mao, Samuel Haywood, Brooke Decker, Tracy Curley, Wassim Abida, Felix Y Feng, Karen Knudsen, Brett Carver, Mario E Lacouture, Alexander W Wyatt, Dana Rathkopf
BACKGROUND: CC-115, a dual mTORC1/2 and DNA-PK inhibitor, has promising antitumour activity when combined with androgen receptor (AR) inhibition in pre-clinical models. METHODS: Phase 1b multicentre trial evaluating enzalutamide with escalating doses of CC-115 in AR inhibitor-naive mCRPC patients (n = 41). Primary endpoints were safety and RP2D. Secondary endpoints included PSA response, time-to-PSA progression, and radiographic progression. RESULTS: Common adverse effects included rash (31...
January 2024: British Journal of Cancer
#26
REVIEW
Heidi Singleton, Preeti Mahato, Emily Arden-Close, Sarah Thomas, Steven Ersser, Debbie Holley, Xiaosong Yang, Amanda Roberts
AIMS AND OBJECTIVES: To map out the primary research studies relating to how virtual reality (VR) has been used to distract children and young people with long-term conditions from pain or pruritus. BACKGROUND: Pharmacologic treatment of chronic pain and pruritus may have side effects; hence, non-invasive non-pharmacological treatments are being sought. DESIGN: The scoping review followed the methodology recommended by the Joanna Briggs Institute, PAGER framework and PRISMA-ScR checklist...
November 14, 2023: Journal of Clinical Nursing
#27
JOURNAL ARTICLE
Xueshan Du, Delu Che, Bin Peng, Yi Zheng, Yong Hao, Tao Jia, Xinyue Zhang, Songmei Geng
BACKGROUND: Topical tacrolimus, although widely used in the treatment of dermatoses, presents with an immediate irritation on initial application resembling a pseudo-allergic reaction. Mas-related G protein-coupled receptor X2 (MRGPRX2) in mast cells (MCs) mediates drug-induced pseudo-allergic reaction and immunoglobulin E (IgE)-independent pruritis in chronic skin diseases. However, the immunosuppression mechanism of tacrolimus on MCs via MRGPRX2 has not been reported. OBJECTIVE: To investigate the role of MRGPRX2 and the mechanism of action of tacrolimus on its short-term and long-term applications...
October 17, 2023: Journal of Dermatological Science
#28
JOURNAL ARTICLE
Harsh R Shah, Jayme A Bertelli
PURPOSE: The sural nerve is the autologous nerve used most commonly for grafting. However, recent studies indicate a high rate of complications and complaints after sural nerve removal. In this prospective study, we evaluated donor-site morbidity following full-length sural nerve harvesting on long-term follow-up. METHODS: Fifty-one legs from 43 patients who underwent complete sural nerve harvesting for brachial plexus reconstruction were included in the study. After an average of 5 years, with a minimum postoperative follow-up of 12 months, sensory deficits in the leg and foot were analyzed using 2...
November 2023: Journal of Hand Surgery
#29
JOURNAL ARTICLE
Takeshi Nakahara, Daisuke Onozuka, Satoshi Nunomura, Hidehisa Saeki, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Ryo Saito, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Makiko Kido-Nakahara, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Norito Katoh, Masutaka Furue, Kenji Izuhara
BACKGROUND: To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out the Biomarkers to Predict Clinical Improvement of AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study in Japan, to explore biomarkers for AD. OBJECTIVE: The aim of this study is to find biomarkers associated with objective and subjective clinical findings in patients with moderate-to-severe AD based on the B-PAD study and to identify biomarkers sensitive enough to assess the severity of AD...
February 2024: J Allergy Clin Immunol Glob
#30
Dina Poplausky, Jade N Young, Danielle P Dubin, Douglas Tremblay, Nicholas Gulati
Dasatinib is a second-generation tyrosine inhibitor that is used for the treatment of patients with chronic myeloid leukemia (CML). It can cause a myriad of skin toxicities, including pruritis, pigmentary abnormalities of hair and skin, and maculopapular rashes. Rarely, it can be associated with acneiform eruptions, which are typically treated with doxycycline. However, doxycycline may not be an ideal therapy, especially for long-term use, due to the risk of gut flora disruption, antimicrobial resistance, and side effects...
September 2023: Curēus
#31
JOURNAL ARTICLE
Milena Wojciechowska, Oliwia McFarlane, Monika Betyna-Białek
BACKGROUND Psoriasis is a chronic systemic skin disease affecting approximately 2% of the global population. In addition to the characteristic inflammatory changes on the skin, patients with psoriasis often experience comorbidities, including depressive symptoms and anxiety. This study aimed to investigate the relationship between the course of psoriasis and the mental state of patients. MATERIAL AND METHODS The study was conducted among 70 patients with psoriasis. An interview was conducted to assess the course of psoriasis...
October 19, 2023: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#32
REVIEW
Matthew Godleski, Miranda Yelvington, Stephanie Jean
Successful post-burn rehabilitation requires an understanding of a wide range of complications to maximize functional recovery. This article reviews a range of potential challenges including burn scar contracture, amputation, peripheral nerve injury, heterotopic ossification, dysphagia, altered skin physiology, pain, and pruritis. The overall focus is to serve as a guide for post-injury therapy and rehabilitation spanning the phases of care and considering evidence-based approaches, prevention, and treatment with an ultimate goal of aiding in the functional recovery and long-term quality of life for burn survivors...
November 2023: Physical Medicine and Rehabilitation Clinics of North America
#33
Maya Biermann, Preeyanka Rubiana Sundar, Hima Veeramachaneni, Field Willingham
Cholestatic pruritus is a debilitating symptom associated with many liver diseases and is often refractory to medical management. Nasobiliary drainage is a relatively safe and effective method for treating intractable cholestatic pruritus. It should be considered for patients with refractory cholestatic pruritus who have failed or have contraindications to medical therapy as a predictor of response before surgical fistula creation.
October 2023: ACG Case Reports Journal
#34
JOURNAL ARTICLE
B S Laughlin, K S Corbin, C S Thorpe, D A S Toesca, M A Golafshar, L A McGee, M Halyard, R W Mutter, S R Keole, S S Park, D Shumway, L A Vallow, T Z Vern-Gross, W W Wong, T A DeWees, C E Vargas
PURPOSE/OBJECTIVE(S): To report a final analysis evaluating physician and patient-reported outcomes of early breast cancer patients receiving moderate hypofractionation or ultra-hypofractionated whole breast radiotherapy (RT). MATERIALS/METHODS: Between April 4, 2018, and February 11, 2020, patients with localized breast cancer (T1-T3, N0-N1, and M0) managed with breast-conserving surgery (BCS) were enrolled. Patients were randomized to receive whole breast RT with moderate hypofractionation to 40 Gy in 15 fractions (Arm A) or ultra-hypofractionation to 25 Gy in 5 fractions (Arm B)...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#35
JOURNAL ARTICLE
Nidhi Sukul, Junhui Zhao, Ronald L Pisoni, Sebastian Walpen, Thilo Schaufler, Elham Asgari, Fitsum Guebre-Egziabher, Li Zho, Mohammed Abdulrahman Al-Ghonaim, Kosaku Nitta, Bruce M Robinson, Angelo Karaboyas
RATIONALE & OBJECTIVE: Cross-sectional studies have reported an association of chronic kidney disease-associated pruritus (CKD-aP) with adverse clinical events and patient-reported outcomes (PROs). We studied the longitudinal associations between changes in CKD-aP and clinical outcomes among patients receiving maintenance hemodialysis. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 7,976 hemodialysis recipients across 21 countries in phases 4-6 (2009-2018) of the Dialysis Outcomes and Practice Patterns Study (DOPPS) who had 2 CKD-aP assessments approximately 12 months apart...
August 16, 2023: American Journal of Kidney Diseases
#36
REVIEW
Nga T Nguyen, Hasan A Khan, Kian Abdul-Baki, Woongsoon Choi, Neel K Shroff, Zahra Akhtar, Peeyush Bhargava
Biliary stents have been widely used to treat both malignant and benign biliary obstruction. Biliary stenting serves as a temporary measure to maintain ductal patency and promote bile drainage. Biliary decompression can help relieve clinical symptoms of pain, obstructive jaundice, pruritis, fat malabsorption, and failure to thrive and prevent disease progression, such as secondary biliary cirrhosis and end-stage liver failure. Endoscopic placement of biliary endoprosthesis is a minimally invasive procedure well tolerated by most patients but is not without problems...
September 21, 2023: Clinical Imaging
#37
REVIEW
Junshik Hong, Johnathan Fraebel, Yenny Yang, Eric Tkacyk, Carrie Kitko, Tae Kon Kim
The skin is the outermost mechanical barrier where dynamic immune reactions take place and is the most commonly affected site in both acute and chronic graft-versus-host disease (GVHD). If not properly treated, pain and pruritis resulting from cutaneous GVHD can increase the risk of secondary infection due to erosions, ulcerations, and damage of underlying tissues. Furthermore, resulting disfiguration can cause distress and significantly impact patients' quality of life. Thus, a deeper understanding of skin-specific findings of GVHD is needed...
December 2023: Bone Marrow Transplantation
#38
JOURNAL ARTICLE
Hong-Van Tieu, Shelly Karuna, Yunda Huang, Magdalena E Sobieszczyk, Hua Zheng, Georgia D Tomaras, David C Montefiori, Mingchao Shen, Stephen DeRosa, Kristen Cohen, Margaret Brewinski Isaacs, Stephanie Regenold, Jack Heptinstall, Kelly E Seaton, Sheetal Sawant, Brianna Furch, Michael Pensiero, Lawrence Corey, Katharine J Bar
BACKGROUND: An approach to a preventive HIV vaccine is induction of effective broadly neutralizing antibodies (bnAbs) and effector binding antibodies (bAbs). Preclinical studies suggest that trimeric envelope (Env) proteins may elicit nAbs, which led to the development of the recombinant gp145 subtype C Env protein (gp145 C.6980) immunogen. HVTN 122 was a Phase 1 trial that evaluated the safety, tolerability, and immunogenicity of gp145 C.6980 in adults. METHODS: Healthy, HIV-1 seronegative adults received three intramuscular injections of gp145 C...
September 5, 2023: Vaccine
#39
Afnan Hasanain, Abdulellah I Aleissa, Wasan AlQurashi
Atopic dermatitis (AD) is a chronic immune-mediated disease characterized by intense pruritis, causing inflammation, itching, and redness of the skin. Dupilumab is a human monoclonal antibody that has been approved for the treatment of atopic dermatitis. It has also been linked with various adverse effects, most of them confined to the injection site. Café-au-lait-macules are benign pigmented lesions of the skin, usually seen in people with genetic disorders. We present a case of café-au-lait macules as an adverse effect of dupilumab therapy in a patient with atopic dermatitis...
July 2023: Curēus
#40
JOURNAL ARTICLE
Mark Simon, Christopher Hoyte
BACKGROUND: Tarantula envenomations are encountered infrequently but may increase with increased exotic animal ownership. This case report presents the first documented toxicity from a Venezuelan suntiger tarantula (VST), Psalmopoeus irminia, and provides a general framework for approaching patients with tarantula exposures. CASE REPORT: A 35-year-old man presented to an emergency department 4 h after experiencing a bite from his pet VST. He developed erythema, pain, and edema to the bite site on the left thenar eminence that extended proximally...
June 10, 2023: Journal of Emergency Medicine
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